psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L258	R:R:S42	4.5	No	No	0	5	6
2	R:R:S42	R:R:Y350	8.9	No	Yes	0	6	4
3	R:R:A92	R:R:F43	4.16	No	Yes	0	7	6
4	R:R:F43	R:R:Y95	4.13	Yes	No	0	6	5
5	R:R:E347	R:R:F43	4.66	No	Yes	0	2	6
6	R:R:F43	R:R:Y350	11.35	Yes	Yes	0	6	4
7	R:R:L44	R:R:R46	13.36	No	Yes	6	4	6
8	R:R:E260	R:R:L44	6.63	No	No	6	2	4
9	R:R:L45	R:R:V257	4.47	No	No	0	6	3
10	R:R:F87	R:R:R46	4.28	No	Yes	0	2	6
11	R:R:E260	R:R:R46	6.98	No	Yes	6	2	6
12	R:R:E347	R:R:R46	5.82	No	Yes	0	2	6
13	R:R:D91	R:R:S89	7.36	No	No	0	3	6
14	R:R:L249	R:R:S93	6.01	No	No	0	4	2
15	R:R:F351	R:R:Y95	12.38	Yes	No	0	1	5
16	R:R:L96	R:R:S166	6.01	No	No	0	5	4
17	R:R:S98	R:R:W100	4.94	No	No	0	7	5
18	R:R:F104	R:R:W100	11.02	No	No	0	5	5
19	R:R:F351	R:R:W100	4.01	Yes	No	0	1	5
20	R:R:L101	R:R:Y162	4.69	No	Yes	0	4	5
21	R:R:F351	R:R:L101	3.65	Yes	No	0	1	4
22	R:R:V105	R:R:Y162	5.05	No	Yes	0	5	5
23	R:R:C358	R:R:V105	8.54	No	No	0	5	5
24	R:R:P106	R:R:Y162	4.17	No	Yes	0	6	5
25	R:R:F163	R:R:P106	17.34	No	No	0	4	6
26	R:R:L155	R:R:Y109	4.69	No	No	0	8	7
27	R:R:C358	R:R:Y109	12.1	No	No	0	5	7
28	R:R:S361	R:R:Y109	7.63	No	No	0	7	7
29	R:R:I159	R:R:T110	7.6	No	No	0	7	4
30	R:R:C365	R:R:V112	5.12	Yes	No	0	8	7
31	R:R:F113	R:R:P156	4.33	No	No	0	7	9
32	R:R:N120	R:R:S116	4.47	No	No	0	9	8
33	R:R:L117	R:R:P118	4.93	No	No	0	6	4
34	R:R:I121	R:R:L117	5.71	No	No	0	4	6
35	R:R:L119	R:R:Y373	7.03	No	No	0	7	7
36	R:R:D148	R:R:N120	8.08	No	No	0	9	9
37	R:R:N120	R:R:P368	13.03	No	No	0	9	9
38	R:R:I121	R:R:V149	4.61	No	No	0	4	7
39	R:R:M122	R:R:Y373	7.18	No	No	0	5	7
40	R:R:A123	R:R:Y372	4	No	Yes	0	8	6
41	R:R:I124	R:R:L142	4.28	No	No	0	7	6
42	R:R:K130	R:R:V126	4.55	No	No	0	5	7
43	R:R:F127	R:R:M141	3.73	No	No	1	6	8
44	R:R:F127	R:R:Y372	9.28	No	Yes	1	6	6
45	R:R:K130	R:R:V382	10.62	No	No	0	5	5
46	R:R:K135	R:R:P136	5.02	No	No	0	7	6
47	R:R:P136	R:R:R214	5.76	No	Yes	0	6	7
48	R:R:A219	R:R:V139	5.09	No	No	0	7	7
49	R:R:I196	R:R:Y140	3.63	No	Yes	0	9	7
50	R:R:D199	R:R:Y140	9.2	No	Yes	0	8	7
51	R:R:A219	R:R:Y140	5.34	No	Yes	0	7	7
52	R:R:C223	R:R:Y140	4.03	No	Yes	0	7	7
53	R:R:M141	R:R:Y372	7.18	No	Yes	1	8	6
54	R:R:C223	R:R:H143	17.69	No	No	0	7	9
55	R:R:H143	R:R:W227	7.41	No	No	0	9	9
56	R:R:L144	R:R:L192	4.15	No	No	0	9	7
57	R:R:A145	R:R:Y372	4	No	Yes	0	8	6
58	R:R:C364	R:R:D148	7.78	No	No	0	8	9
59	R:R:L150	R:R:N185	6.87	No	No	0	6	8
60	R:R:F151	R:R:L155	4.87	Yes	No	0	7	8
61	R:R:F151	R:R:F182	10.72	Yes	Yes	3	7	6
62	R:R:F151	R:R:M186	3.73	Yes	No	3	7	7
63	R:R:F151	R:R:S361	5.28	Yes	No	0	7	7
64	R:R:C364	R:R:F151	4.19	No	Yes	0	8	7
65	R:R:F157	R:R:L174	3.65	No	No	0	6	5
66	R:R:F157	R:R:V178	6.55	No	No	0	6	5
67	R:R:K158	R:R:Y162	4.78	No	Yes	0	6	5
68	R:R:F182	R:R:K158	14.89	Yes	No	0	6	6
69	R:R:F170	R:R:S160	3.96	Yes	No	0	7	4
70	R:R:Y161	R:R:Y162	13.9	Yes	Yes	2	5	5
71	R:R:S166	R:R:Y161	3.82	No	Yes	0	4	5
72	R:R:W168	R:R:Y161	5.79	Yes	Yes	2	9	5
73	R:R:D256	R:R:Y161	10.34	No	Yes	2	4	5
74	R:R:D256	R:R:Y162	5.75	No	Yes	2	4	5
75	R:R:G165	R:R:S166	3.71	No	No	0	4	4
76	R:R:D167	R:R:Q169	9.14	No	No	0	4	2
77	R:R:D167	R:R:I251	8.4	No	No	0	4	2
78	R:R:F170	R:R:W168	18.04	Yes	Yes	0	7	9
79	R:R:C175	R:R:W168	9.14	No	Yes	2	9	9
80	R:R:T243	R:R:W168	4.85	Yes	Yes	2	4	9
81	R:R:C254	R:R:W168	15.67	No	Yes	2	9	9
82	R:R:F170	R:R:L174	4.87	Yes	No	0	7	5
83	R:R:E241	R:R:S172	10.06	No	No	0	4	2
84	R:R:S172	R:R:T243	4.8	No	Yes	0	2	4
85	R:R:C175	R:R:T243	5.07	No	Yes	2	9	4
86	R:R:C175	R:R:C254	7.28	No	No	2	9	9
87	R:R:E241	R:R:R176	12.79	No	No	0	4	7
88	R:R:H255	R:R:T179	9.58	Yes	No	0	4	5
89	R:R:A180	R:R:L238	4.73	No	No	0	6	4
90	R:R:F182	R:R:M186	3.73	Yes	No	3	6	7
91	R:R:L237	R:R:Y183	4.69	No	Yes	0	4	5
92	R:R:H255	R:R:Y183	5.44	Yes	Yes	4	4	5
93	R:R:F271	R:R:Y183	9.28	Yes	Yes	4	5	5
94	R:R:Y183	R:R:Y353	5.96	Yes	Yes	0	5	5
95	R:R:C184	R:R:V234	8.54	No	No	0	5	6
96	R:R:M186	R:R:Y187	7.18	No	Yes	3	7	8
97	R:R:I190	R:R:Y187	3.63	No	Yes	0	7	8
98	R:R:F274	R:R:Y187	16.5	Yes	Yes	3	5	8
99	R:R:F278	R:R:Y187	6.19	Yes	Yes	3	6	8
100	R:R:N330	R:R:Y187	10.47	No	Yes	0	8	8
101	R:R:A188	R:R:W227	3.89	No	No	0	7	9
102	R:R:F326	R:R:I190	12.56	Yes	No	0	9	7
103	R:R:I226	R:R:L191	4.28	No	No	0	7	5
104	R:R:F278	R:R:L191	3.65	Yes	No	0	6	5
105	R:R:I226	R:R:L192	4.28	No	No	0	7	7
106	R:R:F322	R:R:M193	6.22	No	Yes	1	9	8
107	R:R:F326	R:R:M193	3.73	Yes	Yes	1	9	8
108	R:R:D367	R:R:M193	8.32	No	Yes	1	9	8
109	R:R:M193	R:R:Y371	9.58	Yes	Yes	1	8	9
110	R:R:P282	R:R:T194	6.99	No	No	0	9	7
111	R:R:I226	R:R:V195	6.14	No	No	0	7	7
112	R:R:I196	R:R:R200	5.01	No	Yes	0	9	9
113	R:R:S197	R:R:S286	6.52	No	No	0	9	8
114	R:R:C289	R:R:S197	5.16	No	No	0	7	9
115	R:R:S197	R:R:Y290	5.09	No	Yes	0	9	8
116	R:R:D199	R:R:R214	11.91	No	Yes	0	8	7
117	R:R:R200	R:R:Y290	7.2	Yes	Yes	1	9	8
118	R:R:R200	R:R:V318	3.92	Yes	Yes	1	9	8
119	R:R:R200	R:R:Y371	6.17	Yes	Yes	1	9	9
120	R:R:F201	R:R:L202	3.65	Yes	No	0	8	6
121	R:R:F201	R:R:V205	10.49	Yes	No	7	8	7
122	R:R:F201	R:R:Y206	4.13	Yes	Yes	7	8	7
123	R:R:C289	R:R:F201	4.19	No	Yes	0	7	8
124	R:R:F201	R:R:S292	5.28	Yes	No	0	8	3
125	R:R:L202	R:R:W213	6.83	No	No	0	6	3
126	R:R:A203	R:R:R214	6.91	No	Yes	0	8	7
127	R:R:I293	R:R:V204	4.61	No	No	0	8	8
128	R:R:V205	R:R:Y206	7.57	No	Yes	7	7	7
129	R:R:Q209	R:R:Y206	7.89	No	Yes	0	4	7
130	R:R:Q209	R:R:W213	5.48	No	No	0	4	3
131	R:R:R214	R:R:S210	5.27	Yes	No	0	7	5
132	R:R:S212	R:R:W213	6.18	No	No	0	3	3
133	R:R:R218	R:R:T215	7.76	No	No	0	4	6
134	R:R:L239	R:R:V235	4.47	No	No	0	4	4
135	R:R:P236	R:R:Y266	5.56	No	Yes	0	7	4
136	R:R:P236	R:R:Y270	18.08	No	Yes	0	7	5
137	R:R:L237	R:R:Y270	7.03	No	Yes	0	4	5
138	R:R:K240	R:R:Y266	14.33	No	Yes	5	4	4
139	R:R:K240	R:R:Y267	4.78	No	Yes	5	4	4
140	R:R:H255	R:R:Q242	7.42	Yes	No	0	4	4
141	R:R:Q242	R:R:Y267	6.76	No	Yes	0	4	4
142	R:R:T243	R:R:T252	7.85	Yes	No	0	4	5
143	R:R:I251	R:R:V246	7.68	No	No	0	2	3
144	R:R:T253	R:R:V246	4.76	No	No	0	3	3
145	R:R:I251	R:R:L249	4.28	No	No	0	2	4
146	R:R:T253	R:R:V257	9.52	No	No	0	3	3
147	R:R:F271	R:R:H255	4.53	Yes	Yes	4	5	4
148	R:R:D256	R:R:Y350	4.6	No	Yes	0	4	4
149	R:R:L258	R:R:Y267	8.21	No	Yes	0	5	4
150	R:R:L262	R:R:Y266	4.69	No	Yes	5	3	4
151	R:R:L262	R:R:Y267	8.21	No	Yes	5	3	4
152	R:R:L263	R:R:L340	5.54	No	No	0	4	3
153	R:R:E264	R:R:L340	5.3	No	No	0	4	3
154	R:R:Y266	R:R:Y267	7.94	Yes	Yes	5	4	4
155	R:R:F271	R:R:Y270	10.32	Yes	Yes	0	5	5
156	R:R:F274	R:R:Y270	6.19	Yes	Yes	0	5	5
157	R:R:F271	R:R:L333	3.65	Yes	No	4	5	5
158	R:R:F271	R:R:Y337	27.85	Yes	No	4	5	5
159	R:R:F274	R:R:F278	15	Yes	Yes	3	5	6
160	R:R:N330	R:R:S275	5.96	No	No	0	8	5
161	R:R:I334	R:R:S275	6.19	No	No	0	5	5
162	R:R:F278	R:R:V277	5.24	Yes	No	0	6	4
163	R:R:F279	R:R:F280	11.79	Yes	No	0	8	5
164	R:R:F279	R:R:L283	4.87	Yes	No	0	8	6
165	R:R:F279	R:R:G327	4.52	Yes	No	0	8	5
166	R:R:F279	R:R:N330	19.33	Yes	No	0	8	8
167	R:R:F280	R:R:I334	5.02	No	No	0	5	5
168	R:R:F322	R:R:L283	3.65	No	No	0	9	6
169	R:R:F319	R:R:T287	6.49	No	No	0	8	4
170	R:R:V318	R:R:Y290	7.57	Yes	Yes	1	8	8
171	R:R:F319	R:R:Y290	9.28	No	Yes	0	8	8
172	R:R:I293	R:R:L297	4.28	No	Yes	0	8	8
173	R:R:K308	R:R:L297	5.64	No	Yes	0	6	8
174	R:R:S299	R:R:V302	6.46	No	No	0	4	3
175	R:R:K308	R:R:V302	4.55	No	No	0	6	3
176	R:R:L314	R:R:R310	3.64	No	No	0	7	7
177	R:R:Q379	R:R:R310	5.84	No	No	0	8	7
178	R:R:I370	R:R:V318	4.61	No	Yes	1	7	8
179	R:R:V318	R:R:Y371	5.05	Yes	Yes	1	8	9
180	R:R:F319	R:R:I323	8.79	No	No	0	8	5
181	R:R:I321	R:R:I366	7.36	No	No	0	6	7
182	R:R:F322	R:R:F326	4.29	No	Yes	1	9	9
183	R:R:C325	R:R:S363	6.89	No	No	0	8	9
184	R:R:F326	R:R:S363	7.93	Yes	No	0	9	9
185	R:R:G327	R:R:P328	4.06	No	No	0	5	9
186	R:R:L333	R:R:Y337	4.69	No	No	4	5	5
187	R:R:L333	R:R:Y353	11.72	No	Yes	0	5	5
188	R:R:H336	R:R:Y337	14.16	Yes	No	0	4	5
189	R:R:H336	R:R:L340	3.86	Yes	No	0	4	3
190	R:R:H336	R:R:T346	5.48	Yes	No	0	4	1
191	R:R:H336	R:R:Y350	7.62	Yes	Yes	0	4	4
192	R:R:F339	R:R:S338	13.21	No	No	0	3	4
193	R:R:Y350	R:R:Y353	3.97	Yes	Yes	0	4	5
194	R:R:L354	R:R:Y350	11.72	No	Yes	0	4	4
195	R:R:F351	R:R:L355	10.96	Yes	No	0	1	5
196	R:R:V357	R:R:Y353	8.83	No	Yes	0	6	5
197	R:R:I362	R:R:I366	5.89	No	No	0	4	7
198	R:R:D367	R:R:Y371	6.9	No	Yes	1	9	9
199	R:R:P368	R:R:Y372	4.17	No	Yes	0	9	6
200	R:R:I370	R:R:Y371	4.84	No	Yes	1	7	9
201	R:R:Y371	R:R:Y372	3.97	Yes	Yes	1	9	6
202	R:R:C378	R:R:S375	5.16	No	No	0	8	7
203	R:R:Y381	R:R:Y383	3.97	No	No	0	4	5
204	R:R:F151	R:R:N185	3.62	Yes	No	0	7	8
205	R:R:M131	R:R:Y383	3.59	No	No	0	5	5
206	R:R:P236	R:R:V235	3.53	No	No	0	7	4
207	R:R:P247	R:R:V246	3.53	No	No	0	1	3
208	R:R:P282	R:R:V281	3.53	No	No	0	9	5
209	R:R:F170	R:R:Q169	3.51	Yes	No	0	7	2
210	R:R:C365	R:R:V115	3.42	Yes	No	0	8	5
211	R:R:C364	R:R:V152	3.42	No	No	0	8	6
212	R:R:A180	R:R:V234	3.39	No	No	0	6	6
213	R:R:C356	R:R:T329	3.38	No	No	0	6	6
214	R:R:L119	R:R:P368	3.28	No	No	0	7	9
215	R:R:L191	R:R:P282	3.28	No	No	0	5	9
216	R:R:C289	R:R:I198	3.27	No	No	0	7	6
217	R:R:C365	R:R:I362	3.27	Yes	No	0	8	4
218	R:R:A92	R:R:I88	3.25	No	No	0	7	4
219	R:R:A145	R:R:I124	3.25	No	No	0	8	7
220	R:R:V133	R:R:V138	3.21	No	No	0	6	7
221	R:R:S360	R:R:T329	3.2	No	No	0	8	6
222	R:R:C296	R:R:L297	3.17	No	Yes	0	5	8
223	R:R:T329	R:R:V357	3.17	No	No	0	6	6
224	R:R:C356	R:R:L332	3.17	No	No	0	6	5
225	R:R:A374	R:R:L314	3.15	No	No	0	6	7
226	R:R:A352	R:R:L332	3.15	No	No	0	5	5
227	R:R:I293	R:R:S315	3.1	No	No	0	8	7
228	R:R:I334	R:R:S338	3.1	No	No	0	5	4
229	R:R:I124	R:R:V149	3.07	No	No	0	7	7
230	R:R:K307	R:R:S309	3.06	No	No	0	4	4
231	R:R:M131	R:R:V138	3.04	No	No	0	5	7
232	R:R:M141	R:R:V138	3.04	No	No	0	8	7
233	R:R:I285	R:R:T194	3.04	No	No	0	6	7
234	R:R:F274	R:R:G233	3.01	Yes	No	0	5	5
235	R:R:L142	R:R:T146	2.95	No	No	0	6	5
236	R:R:L150	R:R:T146	2.95	No	No	0	6	5
237	R:R:D148	R:R:S189	2.94	No	No	0	9	9
238	R:R:A349	R:R:H336	2.93	No	Yes	0	4	4
239	R:R:G265	R:R:Y269	2.9	No	No	0	3	2
240	R:R:I244	R:R:L45	2.85	No	No	0	2	6
241	R:R:I128	R:R:L129	2.85	No	No	0	4	4
242	R:R:I294	R:R:L312	2.85	No	No	0	4	5
243	R:R:Q245	R:R:T252	2.83	No	No	0	1	5
244	R:R:G171	R:R:W168	2.81	No	Yes	0	8	9
245	R:R:L119	R:R:L369	2.77	No	No	0	7	6
246	R:R:L297	R:R:L312	2.77	Yes	No	0	8	5
247	R:R:A301	R:R:R305	2.77	No	No	0	3	3
248	R:R:L45	R:R:N259	2.75	No	No	0	6	4
249	R:R:M208	R:R:Q209	2.72	No	No	0	4	4
250	R:R:A348	R:R:Y95	2.67	No	No	0	1	5
251	R:R:F163	R:R:S107	2.64	No	No	0	4	5
252	R:R:F313	R:R:S309	2.64	No	No	0	5	4
253	R:R:F127	R:R:V126	2.62	No	No	0	6	7
254	R:R:F182	R:R:V154	2.62	Yes	No	0	6	6
255	R:R:A147	R:R:W227	2.59	No	No	0	8	9
256	R:R:S315	R:R:Y290	2.54	No	Yes	0	7	8
257	R:R:V234	R:R:Y270	2.52	No	Yes	0	6	5
258	R:R:F163	R:R:I159	2.51	No	No	0	4	7
259	R:R:T222	R:R:Y140	2.5	No	Yes	0	5	7
260	R:R:F113	R:R:L155	2.44	No	No	0	7	8
261	R:R:F339	R:R:H342	2.26	No	No	0	3	2
262	R:R:G111	R:R:V114	1.84	No	No	0	5	5
263	R:R:G94	R:R:T97	1.82	No	No	0	4	5
264	R:R:G165	R:R:T102	1.82	No	No	0	4	3
265	R:R:G111	R:R:T110	1.82	No	No	0	5	4
266	R:R:G217	R:R:T215	1.82	No	No	0	4	6
267	R:R:A230	R:R:C184	1.81	No	No	0	8	5
268	R:R:C365	R:R:S116	1.72	Yes	No	0	8	8
269	R:R:A92	R:R:S89	1.71	No	No	0	7	6
270	R:R:C358	R:R:V108	1.71	No	No	0	5	5
271	R:R:G217	R:R:L216	1.71	No	No	0	4	2
272	R:R:A181	R:R:V154	1.7	No	No	0	5	6
273	R:R:G248	R:R:N250	1.7	No	No	0	3	5
274	R:R:A349	R:R:T345	1.68	No	No	0	4	1
275	R:R:L216	R:R:P136	1.64	No	No	0	2	6
276	R:R:C184	R:R:I231	1.64	No	No	0	5	3
277	R:R:C320	R:R:I324	1.64	No	No	0	5	6
278	R:R:S98	R:R:S99	1.63	No	No	0	7	5
279	R:R:S220	R:R:V139	1.62	No	No	0	3	7
280	R:R:S153	R:R:V154	1.62	No	No	0	6	6
281	R:R:S292	R:R:V288	1.62	No	No	0	3	4
282	R:R:S292	R:R:V291	1.62	No	No	0	3	3
283	R:R:A317	R:R:I370	1.62	No	No	0	4	7
284	R:R:S93	R:R:T97	1.6	No	No	0	2	5
285	R:R:I121	R:R:V125	1.54	No	No	0	4	3
286	R:R:K308	R:R:S306	1.53	No	No	0	6	2
287	R:R:F221	R:R:G217	1.51	No	No	0	2	4
288	R:R:L103	R:R:S107	1.5	No	No	0	4	5
289	R:R:L129	R:R:V125	1.49	No	No	0	4	3
290	R:R:N304	R:R:S300	1.49	No	No	0	4	6
291	R:R:E90	R:R:S93	1.44	No	No	0	4	2
292	R:R:Q169	R:R:S164	1.44	No	No	0	2	4
293	R:R:A181	R:R:F177	1.39	No	No	0	5	4
294	R:R:P207	R:R:Y206	1.39	No	Yes	0	8	7
295	R:R:A335	R:R:F339	1.39	No	No	0	5	3
296	R:R:C378	R:R:Y373	1.34	No	No	0	8	7
297	R:R:R295	R:R:S298	1.32	No	No	0	3	4
298	R:R:F280	R:R:V331	1.31	No	No	0	5	6
299	R:R:F221	R:R:L224	1.22	No	No	0	2	4
300	R:R:F278	R:R:L229	1.22	Yes	No	0	6	4
301	R:R:E377	R:R:Y381	1.12	No	No	0	6	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F43	6.075	4	0	6
2	R:R:R46	7.61	4	6	6
3	R:R:Y140	4.94	5	0	7
4	R:R:F151	5.40167	6	3	7
5	R:R:Y161	8.4625	4	2	5
6	R:R:Y162	6.39	6	2	5
7	R:R:W168	9.38333	6	2	9
8	R:R:F170	7.595	4	0	7
9	R:R:F182	7.99	4	3	6
10	R:R:Y183	6.3425	4	4	5
11	R:R:Y187	8.794	5	3	8
12	R:R:M193	6.9625	4	1	8
13	R:R:R200	5.575	4	1	9
14	R:R:F201	5.548	5	7	8
15	R:R:Y206	5.245	4	7	7
16	R:R:R214	7.4625	4	0	7
17	R:R:T243	5.6425	4	2	4
18	R:R:H255	6.7425	4	4	4
19	R:R:Y266	8.13	4	5	4
20	R:R:Y267	7.18	5	5	4
21	R:R:Y270	8.828	5	0	5
22	R:R:F271	11.126	5	4	5
23	R:R:F274	10.175	4	3	5
24	R:R:F278	6.26	5	3	6
25	R:R:F279	10.1275	4	0	8
26	R:R:Y290	6.336	5	1	8
27	R:R:L297	3.965	4	0	8
28	R:R:V318	5.2875	4	1	8
29	R:R:F326	7.1275	4	1	9
30	R:R:H336	6.81	5	0	4
31	R:R:Y350	8.02667	6	0	4
32	R:R:F351	7.75	4	0	1
33	R:R:Y353	7.62	4	0	5
34	R:R:C365	3.3825	4	0	8
35	R:R:Y371	6.085	6	1	9
36	R:R:Y372	5.43333	6	1	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A92	R:R:F43	14.3184	4.16	No	Yes	0	7	6
2	R:R:F43	R:R:Y350	38.4991	11.35	Yes	Yes	0	6	4
3	R:R:E347	R:R:F43	17.8771	4.66	No	Yes	0	2	6
4	R:R:E347	R:R:R46	14.3184	5.82	No	Yes	0	2	6
5	R:R:D256	R:R:Y350	31.9228	4.6	No	Yes	0	4	4
6	R:R:D256	R:R:Y161	14.0237	10.34	No	Yes	2	4	5
7	R:R:W168	R:R:Y161	41.3144	5.79	Yes	Yes	2	9	5
8	R:R:F170	R:R:W168	28.9095	18.04	Yes	Yes	0	7	9
9	R:R:F170	R:R:Q169	22.3772	3.51	Yes	No	0	7	2
10	R:R:D167	R:R:Q169	19.7026	9.14	No	No	0	4	2
11	R:R:D167	R:R:I251	18.3522	8.4	No	No	0	4	2
12	R:R:I251	R:R:V246	10.0647	7.68	No	No	0	2	3
13	R:R:D256	R:R:Y162	18.5897	5.75	No	Yes	2	4	5
14	R:R:P106	R:R:Y162	11.7494	4.17	No	Yes	0	6	5
15	R:R:F163	R:R:P106	10.311	17.34	No	No	0	4	6
16	R:R:F151	R:R:F182	19.2935	10.72	Yes	Yes	3	7	6
17	R:R:F182	R:R:K158	58.4393	14.89	Yes	No	0	6	6
18	R:R:K158	R:R:Y162	58.1006	4.78	No	Yes	0	6	5
19	R:R:D148	R:R:N120	22.6147	8.08	No	No	0	9	9
20	R:R:C364	R:R:D148	22.8786	7.78	No	No	0	8	9
21	R:R:C364	R:R:F151	23.2481	4.19	No	Yes	0	8	7
22	R:R:I124	R:R:V149	10.2802	3.07	No	No	0	7	7
23	R:R:N120	R:R:P368	21.6294	13.03	No	No	0	9	9
24	R:R:Y371	R:R:Y372	32.5518	3.97	Yes	Yes	1	9	6
25	R:R:M193	R:R:Y371	100	9.58	Yes	Yes	1	8	9
26	R:R:F326	R:R:M193	93.78	3.73	Yes	Yes	1	9	8
27	R:R:F326	R:R:I190	95.8914	12.56	Yes	No	0	9	7
28	R:R:I190	R:R:Y187	96.3313	3.63	No	Yes	0	7	8
29	R:R:F274	R:R:Y187	62.9437	16.5	Yes	Yes	3	5	8
30	R:R:F274	R:R:Y270	67.7209	6.19	Yes	Yes	0	5	5
31	R:R:P236	R:R:Y270	11.8154	18.08	No	Yes	0	7	5
32	R:R:P136	R:R:R214	11.943	5.76	No	Yes	0	6	7
33	R:R:D199	R:R:R214	16.1307	11.91	No	Yes	0	8	7
34	R:R:D199	R:R:Y140	17.5692	9.2	No	Yes	0	8	7
35	R:R:I196	R:R:Y140	31.3509	3.63	No	Yes	0	9	7
36	R:R:I196	R:R:R200	32.6486	5.01	No	Yes	0	9	9
37	R:R:R200	R:R:Y371	69.5157	6.17	Yes	Yes	1	9	9
38	R:R:F278	R:R:L191	14.3668	3.65	Yes	No	0	6	5
39	R:R:F182	R:R:M186	41.6927	3.73	Yes	No	3	6	7
40	R:R:M186	R:R:Y187	55.7911	7.18	No	Yes	3	7	8
41	R:R:V234	R:R:Y270	14.0897	2.52	No	Yes	0	6	5
42	R:R:L237	R:R:Y183	16.2011	4.69	No	Yes	0	4	5
43	R:R:L237	R:R:Y270	16.6718	7.03	No	Yes	0	4	5
44	R:R:Y183	R:R:Y353	31.9975	5.96	Yes	Yes	0	5	5
45	R:R:Y350	R:R:Y353	37.4346	3.97	Yes	Yes	0	4	5
46	R:R:N330	R:R:Y187	14.0501	10.47	No	Yes	0	8	8
47	R:R:R200	R:R:Y290	42.3349	7.2	Yes	Yes	1	9	8
48	R:R:S197	R:R:Y290	43.3643	5.09	No	Yes	0	9	8
49	R:R:V318	R:R:Y371	40.2719	5.05	Yes	Yes	1	8	9
50	R:R:V318	R:R:Y290	39.4449	7.57	Yes	Yes	1	8	8
51	R:R:C289	R:R:S197	38.0504	5.16	No	No	0	7	9
52	R:R:C289	R:R:F201	32.7014	4.19	No	Yes	0	7	8
53	R:R:F201	R:R:Y206	11.0192	4.13	Yes	Yes	7	8	7
54	R:R:I293	R:R:S315	27.2555	3.1	No	No	0	8	7
55	R:R:S315	R:R:Y290	29.9652	2.54	No	Yes	0	7	8
56	R:R:H336	R:R:Y350	14.987	7.62	Yes	Yes	0	4	4
57	R:R:L333	R:R:Y353	15.6425	11.72	No	Yes	0	5	5
58	R:R:H336	R:R:Y337	15.8184	14.16	Yes	No	0	4	5
59	R:R:I293	R:R:L297	21.8845	4.28	No	Yes	0	8	8
60	R:R:K308	R:R:L297	10.94	5.64	No	Yes	0	6	8
61	R:R:V357	R:R:Y353	15.7788	8.83	No	Yes	0	6	5
62	R:R:T329	R:R:V357	13.1703	3.17	No	No	0	6	6
63	R:R:P368	R:R:Y372	22.1748	4.17	No	Yes	0	9	6
64	R:R:F271	R:R:Y270	50.904	10.32	Yes	Yes	0	5	5
65	R:R:F271	R:R:Y183	16.1791	9.28	Yes	Yes	4	5	5
66	R:R:F271	R:R:L333	16.1879	3.65	Yes	No	4	5	5
67	R:R:F271	R:R:Y337	16.3727	27.85	Yes	No	4	5	5
68	R:R:Y161	R:R:Y162	33.0929	13.9	Yes	Yes	2	5	5
69	R:R:F278	R:R:Y187	12.9283	6.19	Yes	Yes	3	6	8
70	R:R:F151	R:R:M186	13.9005	3.73	Yes	No	3	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8XOR_nogp

PDB Summary
PDB	8XOR_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.63
Number of Linked Nodes	279
Number of Links	301
Number of Hubs	36
Number of Links mediated by Hubs	138
Number of Communities	7
Number of Nodes involved in Communities	40
Number of Links involved in Communities	50

Path Summary
Number Of Nodes in MetaPath	71
Number Of Links MetaPath	70
Number of Shortest Paths	54249
Length Of Smallest Path	3
Average Path Length	13.1854
Length of Longest Path	30
Minimum Path Strength	1.365
Average Path Strength	6.88225
Maximum Path Strength	21.005
Minimum Path Correlation	0.7
Average Path Correlation	0.924255
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.55556
Average % Of Corr. Nodes	50.2712
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.3866
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body • protein binding • binding • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • G-protein alpha-subunit binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • peptide receptor activity • thrombin-activated receptor activity • proteinase-activated receptor activity • G protein-coupled peptide receptor activity • negative regulation of protein transport • regulation of systemic arterial blood pressure by renin-angiotensin • multicellular organismal process • regulation of systemic arterial blood pressure by hormone • establishment of protein localization • system process • nitrogen compound transport • regulation of renal system process • regulation of system process • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • circulatory system process • renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure • negative regulation of secretion by cell • regulation of biological quality • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • regulation of systemic arterial blood pressure by circulatory renin-angiotensin • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of endocrine process • renin secretion into blood stream • regulation of systemic arterial blood pressure mediated by a chemical signal • transport • negative regulation of renin secretion into blood stream • protein localization to extracellular region • regulation of secretion by cell • secretion by cell • regulation of renin secretion into blood stream • signal release • negative regulation of cellular process • regulation of multicellular organismal process • renal system process involved in regulation of systemic arterial blood pressure • blood circulation • negative regulation of protein localization • renal system process • regulation of transport • secretion • regulation of blood pressure • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • endocrine process • regulation of systemic arterial blood pressure • protein transport • multicellular organismal-level homeostasis • homeostatic process • homeostasis of number of cells within a tissue • anatomical structure homeostasis • tissue homeostasis • homeostasis of number of cells • regulation of tube diameter • regulation of tube size • positive regulation of vasoconstriction • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • blood vessel diameter maintenance • vasoconstriction • regulation of anatomical structure size • thrombin-activated receptor signaling pathway • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • apoptotic process • programmed cell death • leukocyte homeostasis • dendritic cell homeostasis • regulation of body fluid levels • wound healing • cell activation • hemostasis • blood coagulation • response to stress • coagulation • response to wounding • platelet activation • positive regulation of interleukin-8 production • positive regulation of macromolecule biosynthetic process • cytokine production • regulation of cytokine production • positive regulation of macromolecule metabolic process • interleukin-8 production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • positive regulation of gene expression • regulation of macromolecule biosynthetic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of interleukin-8 production • phospholipase C-activating G protein-coupled receptor signaling pathway • regulation of calcium ion transport • positive regulation of calcium ion transport • regulation of monoatomic ion transport • calcium ion transport • metal ion transport • positive regulation of transport • positive regulation of monoatomic ion transport • monoatomic ion transport • monoatomic cation transport • regulation of metal ion transport • positive regulation of coagulation • regulation of response to external stimulus • positive regulation of blood coagulation • regulation of response to wounding • regulation of coagulation • positive regulation of response to stimulus • regulation of response to stress • positive regulation of hemostasis • regulation of hemostasis • positive regulation of response to wounding • regulation of blood coagulation • response to external stimulus • positive regulation of wound healing • regulation of response to stimulus • regulation of wound healing • vesicle organization • platelet dense granule organization • secretory granule organization • endomembrane system organization • regulation of interleukin-1 production • interleukin-1 production • regulation of interleukin-1 beta production • interleukin-1 beta production • collagen biosynthetic process • regulation of collagen biosynthetic process • regulation of collagen metabolic process • positive regulation of collagen metabolic process • positive regulation of collagen biosynthetic process • collagen metabolic process • cell junction organization • neuromuscular junction development • establishment of synaptic specificity at neuromuscular junction • synapse organization • positive regulation of cytosolic calcium ion concentration • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of canonical NF-kappaB signal transduction • regulation of signal transduction • intracellular signal transduction • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of intracellular signal transduction • canonical NF-kappaB signal transduction • regulation of cell communication • regulation of canonical NF-kappaB signal transduction • positive regulation of signaling • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • interleukin-6 production • positive regulation of interleukin-6 production • regulation of interleukin-6 production • positive regulation of molecular function • regulation of molecular function • positive regulation of hydrolase activity • regulation of catalytic activity • regulation of hydrolase activity • positive regulation of catalytic activity • regulation of GTPase activity • positive regulation of GTPase activity • nervous system process • sensory perception of pain • regulation of nervous system process • sensory perception • regulation of sensory perception • regulation of sensory perception of pain • connective tissue replacement involved in inflammatory response wound healing • wound healing involved in inflammatory response • defense response • inflammatory response to wounding • tissue remodeling • connective tissue replacement • inflammatory response • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • Rho protein signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • positive regulation of small GTPase mediated signal transduction • trans-synaptic signaling • trans-synaptic signaling, modulating synaptic transmission • modulation of chemical synaptic transmission • trans-synaptic signaling by endocannabinoid • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • trans-synaptic signaling by lipid, modulating synaptic transmission • anterograde trans-synaptic signaling • trans-synaptic signaling by lipid • trans-synaptic signaling by endocannabinoid, modulating synaptic transmission • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • developmental process • anatomical structure morphogenesis • anatomical structure development • neuron apoptotic process • negative regulation of neuron apoptotic process • negative regulation of programmed cell death • negative regulation of apoptotic process • regulation of neuron apoptotic process • negative regulation of glomerular filtration • regulation of glomerular filtration • renal system process involved in regulation of blood volume • negative regulation of multicellular organismal process • glomerular filtration • renal filtration • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • negative regulation of cell population proliferation • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • locomotion • inorganic ion homeostasis • intracellular calcium ion homeostasis • monoatomic ion transmembrane transport • calcium ion homeostasis • negative regulation of sequestering of calcium ion • maintenance of location in cell • monoatomic cation transmembrane transport • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • regulation of sequestering of calcium ion • intracellular monoatomic ion homeostasis • calcium ion transmembrane import into cytosol • sequestering of calcium ion • inorganic ion transmembrane transport • inorganic cation transmembrane transport • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • cellular homeostasis • chemical homeostasis • calcium ion transmembrane transport • cell surface receptor signaling pathway via STAT • positive regulation of receptor signaling pathway via STAT • positive regulation of receptor signaling pathway via JAK-STAT • regulation of receptor signaling pathway via JAK-STAT • cell surface receptor signaling pathway • regulation of receptor signaling pathway via STAT • cell surface receptor signaling pathway via JAK-STAT • regulation of synaptic plasticity • positive regulation of DNA-templated transcription • RNA metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • positive regulation of nucleobase-containing compound metabolic process • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • positive regulation of smooth muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • smooth muscle contraction • regulation of muscle contraction • regulation of smooth muscle contraction • positive regulation of muscle contraction • cell junction maintenance • cellular component maintenance • cell-cell junction maintenance • cell-cell junction organization • positive regulation of cation transmembrane transport • positive regulation of monoatomic ion transmembrane transport • regulation of release of sequestered calcium ion into cytosol • regulation of transmembrane transport • regulation of monoatomic ion transmembrane transport • regulation of calcium ion transmembrane transport • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • positive regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic cation transmembrane transport • biological process involved in interspecies interaction between organisms • response to other organism • response to lipopolysaccharide • response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • postsynapse • postsynaptic membrane • synaptic membrane • neuromuscular junction • cell surface • membrane microdomain • membrane raft • plasma membrane raft • caveola • early endosome • endosome • intracellular vesicle • cytoplasmic vesicle • platelet dense tubular network • late endosome
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25116
Sequence	>8XOR_nogp_Chain_R S F L L R N P A F I S E D A S G Y L T S S W L T L F V P S V Y T G V F V V S L P L N I M A I V V F I L K M K V K K P A V V Y M L H L A T A D V L F V S V L P F K I S Y Y F S G S D W Q F G S E L C R F V T A A F Y C N M Y A S I L L M T V I S I D R F L A V V Y P M Q S L S W R T L G R A S F T C L A I W A L A I A G V V P L L L K E Q T I Q V P G L N I T T C H D V L N E T L L E G Y Y A Y Y F S A F S A V F F F V P L I I S T V C Y V S I I R C L S S S A V A N R S K K S R A L F L S A A V F C I F I I C F G P T N V L L I A H Y S F L S H T S T T E A A Y F A Y L L C V C V S S I S C C I D P L I Y Y Y A S S E C Q R Y V Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XOR	A	Peptide	Proteinase-activated	PAR1	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2024-09-18	doi.org/10.1038/s41422-024-00997-2
	8XOR (No Gprot)	A	Peptide	Proteinase-activated	PAR1	Homo sapiens	-	-		3	2024-09-18	doi.org/10.1038/s41422-024-00997-2
	8XOS	A	Peptide	Proteinase-activated	PAR1	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2024-09-18	doi.org/10.1038/s41422-024-00997-2
	8XOS (No Gprot)	A	Peptide	Proteinase-activated	PAR1	Homo sapiens	-	-		3.2	2024-09-18	doi.org/10.1038/s41422-024-00997-2
	3VW7	A	Peptide	Proteinase Activated	PAR1	Homo sapiens	-	Vorapaxar; Na	-	2.2	2012-12-12	10.1038/nature11701

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