psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L258	R:R:S42	9.01	Yes	No	0	5	6
2	R:R:A92	R:R:F43	4.16	No	Yes	3	7	6
3	R:R:F43	R:R:L96	7.31	Yes	No	0	6	5
4	R:R:E347	R:R:F43	8.16	No	Yes	3	2	6
5	R:R:F43	R:R:Y350	10.32	Yes	Yes	0	6	4
6	R:R:L44	R:R:R46	6.07	No	Yes	4	4	6
7	R:R:E260	R:R:L44	5.3	No	No	4	2	4
8	R:R:L263	R:R:L44	4.15	No	No	0	4	4
9	R:R:F87	R:R:R46	6.41	No	Yes	0	2	6
10	R:R:E260	R:R:R46	12.79	No	Yes	4	2	6
11	R:R:F87	R:R:N47	4.83	No	No	0	2	6
12	R:R:A86	R:R:P247	3.74	No	No	0	5	1
13	R:R:D91	R:R:S89	8.83	No	No	0	3	6
14	R:R:E90	R:R:S93	7.19	No	No	0	4	2
15	R:R:A92	R:R:E347	4.53	No	No	3	7	2
16	R:R:F351	R:R:Y95	19.6	Yes	No	0	1	5
17	R:R:L96	R:R:S166	6.01	No	Yes	0	5	4
18	R:R:S98	R:R:W100	4.94	No	No	0	7	5
19	R:R:F104	R:R:W100	4.01	No	No	0	5	5
20	R:R:F351	R:R:W100	5.01	Yes	No	0	1	5
21	R:R:F351	R:R:L101	3.65	Yes	No	0	1	4
22	R:R:L101	R:R:L354	4.15	No	No	0	4	4
23	R:R:L103	R:R:T102	4.42	No	No	0	4	3
24	R:R:F104	R:R:V108	7.87	No	No	0	5	5
25	R:R:V105	R:R:Y162	5.05	No	Yes	0	5	5
26	R:R:C358	R:R:V105	6.83	No	No	0	5	5
27	R:R:P106	R:R:Y162	4.17	No	Yes	0	6	5
28	R:R:F163	R:R:P106	17.34	No	No	0	4	6
29	R:R:L155	R:R:Y109	8.21	No	No	0	8	7
30	R:R:C358	R:R:Y109	9.41	No	No	0	5	7
31	R:R:S361	R:R:Y109	5.09	No	No	0	7	7
32	R:R:I159	R:R:T110	7.6	No	No	0	7	4
33	R:R:S361	R:R:V112	4.85	No	No	0	7	7
34	R:R:C365	R:R:V112	5.12	Yes	No	0	8	7
35	R:R:F113	R:R:L117	3.65	No	Yes	0	7	6
36	R:R:F113	R:R:P156	7.22	No	No	0	7	9
37	R:R:N120	R:R:S116	4.47	No	No	0	9	8
38	R:R:L119	R:R:P368	4.93	No	No	0	7	9
39	R:R:D148	R:R:N120	10.77	No	No	0	9	9
40	R:R:N120	R:R:P368	9.77	No	No	0	9	9
41	R:R:A123	R:R:Y372	5.34	No	Yes	0	8	6
42	R:R:F127	R:R:V138	3.93	Yes	No	0	6	7
43	R:R:F127	R:R:M141	9.95	Yes	No	5	6	8
44	R:R:F127	R:R:Y372	6.19	Yes	Yes	5	6	6
45	R:R:C378	R:R:K130	4.85	No	No	0	8	5
46	R:R:E377	R:R:M131	5.41	No	No	0	6	5
47	R:R:K132	R:R:K134	7.18	No	No	0	6	5
48	R:R:K134	R:R:K135	5.75	No	No	0	5	7
49	R:R:L216	R:R:P136	6.57	No	No	0	2	6
50	R:R:A219	R:R:V139	5.09	No	No	0	7	7
51	R:R:V195	R:R:Y140	6.31	No	Yes	0	7	7
52	R:R:I196	R:R:Y140	4.84	No	Yes	0	9	7
53	R:R:D199	R:R:Y140	6.9	No	Yes	0	8	7
54	R:R:A219	R:R:Y140	5.34	No	Yes	0	7	7
55	R:R:C223	R:R:Y140	4.03	No	Yes	0	7	7
56	R:R:M141	R:R:Y372	7.18	No	Yes	5	8	6
57	R:R:H143	R:R:L192	3.86	No	No	0	9	7
58	R:R:C223	R:R:H143	16.22	No	No	0	7	9
59	R:R:H143	R:R:W227	7.41	No	No	0	9	9
60	R:R:L144	R:R:L192	4.15	No	No	0	9	7
61	R:R:L144	R:R:Y372	8.21	No	Yes	0	9	6
62	R:R:A145	R:R:Y372	4	No	Yes	0	8	6
63	R:R:C364	R:R:D148	9.34	No	No	0	8	9
64	R:R:L150	R:R:N185	6.87	No	No	0	6	8
65	R:R:F151	R:R:F182	7.5	Yes	No	0	7	6
66	R:R:F151	R:R:N185	4.83	Yes	No	0	7	8
67	R:R:F151	R:R:M186	4.98	Yes	No	0	7	7
68	R:R:F151	R:R:S361	5.28	Yes	No	0	7	7
69	R:R:F157	R:R:F170	5.36	No	Yes	0	6	7
70	R:R:F157	R:R:V178	5.24	No	No	0	6	5
71	R:R:F182	R:R:K158	14.89	No	No	0	6	6
72	R:R:Y161	R:R:Y162	11.91	Yes	Yes	1	5	5
73	R:R:S166	R:R:Y161	5.09	Yes	Yes	0	4	5
74	R:R:W168	R:R:Y161	9.65	Yes	Yes	1	9	5
75	R:R:T253	R:R:Y161	4.99	No	Yes	1	3	5
76	R:R:D256	R:R:Y161	10.34	No	Yes	1	4	5
77	R:R:D256	R:R:Y162	5.75	No	Yes	1	4	5
78	R:R:G165	R:R:S166	3.71	No	Yes	0	4	4
79	R:R:F170	R:R:W168	20.04	Yes	Yes	0	7	9
80	R:R:C175	R:R:W168	10.45	No	Yes	1	9	9
81	R:R:C254	R:R:W168	14.37	No	Yes	1	9	9
82	R:R:F170	R:R:Q169	15.23	Yes	No	0	7	2
83	R:R:F170	R:R:L174	3.65	Yes	No	0	7	5
84	R:R:E241	R:R:S172	11.5	No	No	1	4	2
85	R:R:S172	R:R:T243	4.8	No	Yes	1	2	4
86	R:R:E173	R:R:L174	3.98	No	No	0	2	5
87	R:R:C175	R:R:T243	5.07	No	Yes	1	9	4
88	R:R:C175	R:R:C254	7.28	No	No	1	9	9
89	R:R:L238	R:R:R176	6.07	No	No	0	4	7
90	R:R:L237	R:R:T179	4.42	No	No	0	4	5
91	R:R:H255	R:R:T179	8.21	Yes	No	0	4	5
92	R:R:F182	R:R:Y183	4.13	No	No	0	6	5
93	R:R:F271	R:R:Y183	8.25	Yes	No	0	5	5
94	R:R:Y183	R:R:Y353	4.96	No	Yes	0	5	5
95	R:R:M186	R:R:Y187	9.58	No	Yes	0	7	8
96	R:R:F274	R:R:Y187	17.54	Yes	Yes	6	5	8
97	R:R:F278	R:R:Y187	5.16	Yes	Yes	6	6	8
98	R:R:N330	R:R:Y187	9.3	No	Yes	0	8	8
99	R:R:A188	R:R:W227	3.89	No	No	0	7	9
100	R:R:F326	R:R:I190	11.3	Yes	No	0	9	7
101	R:R:I226	R:R:L191	4.28	No	No	0	7	5
102	R:R:F322	R:R:M193	4.98	No	Yes	0	9	8
103	R:R:F326	R:R:M193	3.73	Yes	Yes	0	9	8
104	R:R:D367	R:R:M193	5.54	No	Yes	0	9	8
105	R:R:M193	R:R:Y371	8.38	Yes	No	0	8	9
106	R:R:P282	R:R:T194	6.99	No	No	0	9	7
107	R:R:I196	R:R:R200	5.01	No	No	0	9	9
108	R:R:S197	R:R:S286	6.52	No	No	0	9	8
109	R:R:C289	R:R:S197	5.16	No	No	0	7	9
110	R:R:S197	R:R:Y290	5.09	No	Yes	0	9	8
111	R:R:D199	R:R:R214	9.53	No	No	0	8	7
112	R:R:R200	R:R:Y290	7.2	No	Yes	0	9	8
113	R:R:R200	R:R:Y371	6.17	No	No	0	9	9
114	R:R:F201	R:R:L202	3.65	Yes	No	0	8	6
115	R:R:F201	R:R:V205	11.8	Yes	No	7	8	7
116	R:R:F201	R:R:Y206	4.13	Yes	No	7	8	7
117	R:R:C289	R:R:F201	5.59	No	Yes	0	7	8
118	R:R:F201	R:R:S292	5.28	Yes	No	0	8	3
119	R:R:A203	R:R:R214	6.91	No	No	0	8	7
120	R:R:V205	R:R:Y206	3.79	No	No	7	7	7
121	R:R:M208	R:R:Q209	4.08	No	No	0	4	4
122	R:R:Q209	R:R:W213	10.95	No	No	0	4	3
123	R:R:R218	R:R:T215	12.94	No	No	0	4	6
124	R:R:F278	R:R:L229	3.65	Yes	No	0	6	4
125	R:R:P236	R:R:Y266	4.17	No	No	0	7	4
126	R:R:P236	R:R:Y270	13.91	No	Yes	0	7	5
127	R:R:L237	R:R:Y270	4.69	No	Yes	0	4	5
128	R:R:K240	R:R:Y266	13.14	No	No	8	4	4
129	R:R:K240	R:R:Y267	4.78	No	Yes	8	4	4
130	R:R:E241	R:R:T243	4.23	No	Yes	1	4	4
131	R:R:H255	R:R:Q242	3.71	Yes	No	0	4	4
132	R:R:Q242	R:R:Y267	9.02	No	Yes	0	4	4
133	R:R:Q245	R:R:T252	4.25	No	No	0	1	5
134	R:R:V246	R:R:V257	4.81	Yes	No	0	3	3
135	R:R:D256	R:R:T253	4.34	No	No	1	4	3
136	R:R:T253	R:R:V257	6.35	No	No	0	3	3
137	R:R:H255	R:R:L258	5.14	Yes	Yes	0	4	5
138	R:R:F271	R:R:H255	4.53	Yes	Yes	0	5	4
139	R:R:L258	R:R:L263	6.92	Yes	No	0	5	4
140	R:R:L258	R:R:Y267	11.72	Yes	Yes	0	5	4
141	R:R:N259	R:R:T261	11.7	No	No	0	4	1
142	R:R:L262	R:R:N259	8.24	No	No	0	3	4
143	R:R:E264	R:R:L340	3.98	No	No	0	4	3
144	R:R:Y266	R:R:Y267	4.96	No	Yes	8	4	4
145	R:R:F271	R:R:Y270	13.41	Yes	Yes	0	5	5
146	R:R:F274	R:R:Y270	8.25	Yes	Yes	0	5	5
147	R:R:F271	R:R:Y337	22.69	Yes	No	0	5	5
148	R:R:F274	R:R:F278	7.5	Yes	Yes	6	5	6
149	R:R:N330	R:R:S275	5.96	No	No	0	8	5
150	R:R:L333	R:R:S275	4.5	No	No	0	5	5
151	R:R:F278	R:R:V277	5.24	Yes	No	0	6	4
152	R:R:F279	R:R:F280	12.86	Yes	No	0	8	5
153	R:R:F279	R:R:L283	6.09	Yes	No	0	8	6
154	R:R:F279	R:R:G327	4.52	Yes	No	0	8	5
155	R:R:F279	R:R:N330	24.17	Yes	No	0	8	8
156	R:R:F322	R:R:L283	3.65	No	No	0	9	6
157	R:R:F319	R:R:T287	6.49	No	No	0	8	4
158	R:R:V318	R:R:Y290	6.31	No	Yes	0	8	8
159	R:R:F319	R:R:Y290	7.22	No	Yes	0	8	8
160	R:R:I294	R:R:L312	4.28	No	No	0	4	5
161	R:R:I294	R:R:S315	4.64	No	No	0	4	7
162	R:R:K308	R:R:L297	8.46	No	Yes	0	6	8
163	R:R:N304	R:R:R305	6.03	No	No	0	4	3
164	R:R:I370	R:R:V318	6.14	No	No	0	7	8
165	R:R:V318	R:R:Y371	5.05	No	No	0	8	9
166	R:R:F319	R:R:I323	6.28	No	No	0	8	5
167	R:R:I321	R:R:I366	7.36	No	No	2	6	7
168	R:R:C325	R:R:F326	5.59	Yes	Yes	2	8	9
169	R:R:C325	R:R:S363	6.89	Yes	No	2	8	9
170	R:R:F326	R:R:S363	5.28	Yes	No	2	9	9
171	R:R:G327	R:R:P328	4.06	No	No	0	5	9
172	R:R:T329	R:R:Y353	4.99	No	Yes	0	6	5
173	R:R:C356	R:R:T329	5.07	No	No	0	6	6
174	R:R:L333	R:R:Y353	16.41	No	Yes	0	5	5
175	R:R:H336	R:R:Y337	14.16	Yes	No	0	4	5
176	R:R:H336	R:R:L340	3.86	Yes	No	0	4	3
177	R:R:H336	R:R:T346	4.11	Yes	No	0	4	1
178	R:R:H336	R:R:Y350	15.24	Yes	Yes	0	4	4
179	R:R:F339	R:R:S338	11.89	No	No	0	3	4
180	R:R:H342	R:R:S344	4.18	No	No	0	2	3
181	R:R:H342	R:R:T345	17.8	No	No	0	2	1
182	R:R:Y350	R:R:Y353	8.94	Yes	Yes	0	4	5
183	R:R:L354	R:R:Y350	11.72	No	Yes	0	4	4
184	R:R:F351	R:R:L355	4.87	Yes	No	0	1	5
185	R:R:V357	R:R:Y353	8.83	No	Yes	0	6	5
186	R:R:P368	R:R:Y372	4.17	No	Yes	0	9	6
187	R:R:E377	R:R:S375	5.75	No	No	0	6	7
188	R:R:G111	R:R:T110	3.64	No	No	0	5	4
189	R:R:L314	R:R:R310	3.64	No	No	0	7	7
190	R:R:M122	R:R:Y373	3.59	No	No	0	5	7
191	R:R:P236	R:R:V235	3.53	No	No	0	7	4
192	R:R:P282	R:R:V281	3.53	No	No	0	9	5
193	R:R:L262	R:R:Y267	3.52	No	Yes	0	3	4
194	R:R:C365	R:R:V115	3.42	Yes	No	0	8	5
195	R:R:C184	R:R:V234	3.42	No	No	0	5	6
196	R:R:L202	R:R:W213	3.42	No	No	0	6	3
197	R:R:A180	R:R:V234	3.39	No	No	0	6	6
198	R:R:L117	R:R:P118	3.28	Yes	No	0	6	4
199	R:R:E173	R:R:G171	3.27	No	No	0	2	8
200	R:R:C184	R:R:I231	3.27	No	No	0	5	3
201	R:R:C289	R:R:I198	3.27	No	No	0	7	6
202	R:R:C365	R:R:I362	3.27	Yes	No	0	8	4
203	R:R:S116	R:R:V152	3.23	No	No	0	8	6
204	R:R:V133	R:R:V139	3.21	No	No	0	6	7
205	R:R:S286	R:R:T194	3.2	No	No	0	8	7
206	R:R:S360	R:R:T329	3.2	No	No	0	8	6
207	R:R:T222	R:R:V195	3.17	No	No	0	5	7
208	R:R:C356	R:R:L332	3.17	No	No	0	6	5
209	R:R:A180	R:R:L238	3.15	No	No	0	6	4
210	R:R:A311	R:R:L297	3.15	No	Yes	0	7	8
211	R:R:A374	R:R:L314	3.15	No	No	0	6	7
212	R:R:A352	R:R:L332	3.15	No	No	0	5	5
213	R:R:I251	R:R:S166	3.1	No	Yes	0	2	4
214	R:R:I334	R:R:S275	3.1	No	No	0	5	5
215	R:R:I88	R:R:V246	3.07	No	Yes	0	4	3
216	R:R:I226	R:R:V195	3.07	No	No	0	7	7
217	R:R:I244	R:R:V246	3.07	No	Yes	0	2	3
218	R:R:I285	R:R:V281	3.07	No	No	0	6	5
219	R:R:K308	R:R:S306	3.06	No	No	0	6	2
220	R:R:K307	R:R:S309	3.06	No	No	0	4	4
221	R:R:K130	R:R:V126	3.04	No	No	0	5	7
222	R:R:F274	R:R:G233	3.01	Yes	No	0	5	5
223	R:R:L312	R:R:S298	3	No	No	0	5	4
224	R:R:L117	R:R:V152	2.98	Yes	No	0	6	6
225	R:R:L129	R:R:V125	2.98	No	No	0	4	3
226	R:R:L239	R:R:V235	2.98	No	No	0	4	4
227	R:R:D148	R:R:S189	2.94	No	No	0	9	9
228	R:R:D167	R:R:S164	2.94	No	No	0	4	4
229	R:R:I124	R:R:L142	2.85	Yes	No	0	7	6
230	R:R:I128	R:R:L129	2.85	No	No	0	4	4
231	R:R:I251	R:R:L249	2.85	No	No	0	2	4
232	R:R:I370	R:R:L314	2.85	No	No	0	7	7
233	R:R:A181	R:R:F177	2.77	No	No	0	5	4
234	R:R:L297	R:R:L312	2.77	Yes	No	0	8	5
235	R:R:A335	R:R:F339	2.77	No	No	0	5	3
236	R:R:L249	R:R:N250	2.75	No	No	0	4	5
237	R:R:A348	R:R:Y95	2.67	No	No	0	1	5
238	R:R:A123	R:R:Y373	2.67	No	No	0	8	7
239	R:R:F170	R:R:S160	2.64	Yes	No	0	7	4
240	R:R:F313	R:R:S309	2.64	No	No	0	5	4
241	R:R:F127	R:R:V126	2.62	Yes	No	0	6	7
242	R:R:D91	R:R:E347	2.6	No	No	0	3	2
243	R:R:R46	R:R:T343	2.59	Yes	No	0	6	6
244	R:R:A147	R:R:W227	2.59	No	No	0	8	9
245	R:R:S315	R:R:Y290	2.54	No	Yes	0	7	8
246	R:R:V234	R:R:Y270	2.52	No	Yes	0	6	5
247	R:R:F163	R:R:I159	2.51	No	No	0	4	7
248	R:R:F201	R:R:I293	2.51	Yes	No	0	8	8
249	R:R:E377	R:R:F127	2.33	No	Yes	0	6	6
250	R:R:A219	R:R:P136	1.87	No	No	0	7	6
251	R:R:G94	R:R:S93	1.86	No	No	0	4	2
252	R:R:G165	R:R:S164	1.86	No	No	0	4	4
253	R:R:G217	R:R:S220	1.86	No	No	0	4	3
254	R:R:G111	R:R:V114	1.84	No	No	0	5	5
255	R:R:G94	R:R:T97	1.82	No	No	0	4	5
256	R:R:G165	R:R:T102	1.82	No	No	0	4	3
257	R:R:G217	R:R:T215	1.82	No	No	0	4	6
258	R:R:A230	R:R:C184	1.81	No	No	0	8	5
259	R:R:P247	R:R:V246	1.77	No	Yes	0	1	3
260	R:R:G248	R:R:I251	1.76	No	No	0	3	2
261	R:R:C296	R:R:V205	1.71	No	No	0	5	7
262	R:R:G217	R:R:L216	1.71	No	No	0	4	2
263	R:R:A181	R:R:V154	1.7	No	No	0	5	6
264	R:R:M208	R:R:P207	1.68	No	No	0	4	8
265	R:R:K135	R:R:P136	1.67	No	No	0	7	6
266	R:R:E264	R:R:G265	1.64	No	No	0	4	3
267	R:R:C325	R:R:I321	1.64	Yes	No	2	8	6
268	R:R:C325	R:R:I366	1.64	Yes	No	2	8	7
269	R:R:C365	R:R:I366	1.64	Yes	No	0	8	7
270	R:R:S98	R:R:S99	1.63	No	No	0	7	5
271	R:R:S107	R:R:V108	1.62	No	No	0	5	5
272	R:R:A145	R:R:I124	1.62	No	Yes	0	8	7
273	R:R:S292	R:R:V288	1.62	No	No	0	3	4
274	R:R:A317	R:R:I370	1.62	No	No	0	4	7
275	R:R:A137	R:R:M141	1.61	No	No	0	7	8
276	R:R:V125	R:R:V126	1.6	No	No	0	3	7
277	R:R:T287	R:R:V291	1.59	No	No	0	4	3
278	R:R:A86	R:R:L45	1.58	No	No	0	5	6
279	R:R:A268	R:R:L340	1.58	No	No	0	3	3
280	R:R:T243	R:R:T252	1.57	Yes	No	0	4	5
281	R:R:A181	R:R:N185	1.56	No	No	0	5	8
282	R:R:I88	R:R:S93	1.55	No	No	0	4	2
283	R:R:I334	R:R:S338	1.55	No	No	0	5	4
284	R:R:I284	R:R:V288	1.54	No	No	0	3	4
285	R:R:C378	R:R:Q379	1.53	No	No	0	8	8
286	R:R:I124	R:R:T146	1.52	Yes	No	0	7	5
287	R:R:L117	R:R:V149	1.49	Yes	No	0	6	7
288	R:R:L150	R:R:V149	1.49	No	No	0	6	7
289	R:R:L297	R:R:V204	1.49	Yes	No	0	8	8
290	R:R:I121	R:R:I124	1.47	No	Yes	0	4	7
291	R:R:A349	R:R:H336	1.46	No	Yes	0	4	4
292	R:R:L211	R:R:M208	1.41	No	No	0	5	4
293	R:R:K308	R:R:N304	1.4	No	No	0	6	4
294	R:R:L119	R:R:L369	1.38	No	No	0	7	6
295	R:R:R214	R:R:S210	1.32	No	No	0	7	5
296	R:R:F280	R:R:V331	1.31	No	No	0	5	6
297	R:R:S212	R:R:W213	1.24	No	No	0	3	3
298	R:R:F339	R:R:H342	1.13	No	No	0	3	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F43	7.4875	4	3	6
2	R:R:R46	6.965	4	4	6
3	R:R:L117	2.85	4	0	6
4	R:R:I124	1.865	4	0	7
5	R:R:F127	5.004	5	5	6
6	R:R:Y140	5.484	5	0	7
7	R:R:F151	5.6475	4	0	7
8	R:R:Y161	8.396	5	1	5
9	R:R:Y162	6.72	4	1	5
10	R:R:S166	4.4775	4	0	4
11	R:R:W168	13.6275	4	1	9
12	R:R:F170	9.384	5	0	7
13	R:R:Y187	10.395	4	6	8
14	R:R:M193	5.6575	4	0	8
15	R:R:F201	5.49333	6	7	8
16	R:R:T243	3.9175	4	1	4
17	R:R:V246	3.18	4	0	3
18	R:R:H255	5.3975	4	0	4
19	R:R:L258	8.1975	4	0	5
20	R:R:Y267	6.8	5	8	4
21	R:R:Y270	8.556	5	0	5
22	R:R:F271	12.22	4	0	5
23	R:R:F274	9.075	4	6	5
24	R:R:F278	5.3875	4	6	6
25	R:R:F279	11.91	4	0	8
26	R:R:Y290	5.672	5	0	8
27	R:R:L297	3.9675	4	0	8
28	R:R:C325	3.94	4	2	8
29	R:R:F326	6.475	4	2	9
30	R:R:H336	7.766	5	0	4
31	R:R:Y350	11.555	4	0	4
32	R:R:F351	8.2825	4	0	1
33	R:R:Y353	8.826	5	0	5
34	R:R:C365	3.3625	4	0	8
35	R:R:Y372	5.84833	6	5	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F43	R:R:Y350	44.5671	10.32	Yes	Yes	0	6	4
2	R:R:H336	R:R:Y350	21.7886	15.24	Yes	Yes	0	4	4
3	R:R:H336	R:R:Y337	16.2846	14.16	Yes	No	0	4	5
4	R:R:F271	R:R:Y337	17.0377	22.69	Yes	No	0	5	5
5	R:R:F271	R:R:H255	30.6271	4.53	Yes	Yes	0	5	4
6	R:R:H255	R:R:L258	21.2012	5.14	Yes	Yes	0	4	5
7	R:R:Y350	R:R:Y353	51.4352	8.94	Yes	Yes	0	4	5
8	R:R:Y183	R:R:Y353	28.093	4.96	No	Yes	0	5	5
9	R:R:F271	R:R:Y183	29.0877	8.25	Yes	No	0	5	5
10	R:R:F43	R:R:L96	38.4473	7.31	Yes	No	0	6	5
11	R:R:L258	R:R:L263	12.7274	6.92	Yes	No	0	5	4
12	R:R:L263	R:R:L44	10.9369	4.15	No	No	0	4	4
13	R:R:V246	R:R:V257	25.7626	4.81	Yes	No	0	3	3
14	R:R:T253	R:R:V257	28.2872	6.35	No	No	0	3	3
15	R:R:T253	R:R:Y161	19.8892	4.99	No	Yes	1	3	5
16	R:R:S166	R:R:Y161	27.6052	5.09	Yes	Yes	0	4	5
17	R:R:L96	R:R:S166	37.3626	6.01	No	Yes	0	5	4
18	R:R:I88	R:R:S93	10.4159	1.55	No	No	0	4	2
19	R:R:I88	R:R:V246	12.9973	3.07	No	Yes	0	4	3
20	R:R:F351	R:R:L101	16.9288	3.65	Yes	No	0	1	4
21	R:R:L101	R:R:L354	18.454	4.15	No	No	0	4	4
22	R:R:L354	R:R:Y350	20.0455	11.72	No	Yes	0	4	4
23	R:R:F351	R:R:W100	10.2738	5.01	Yes	No	0	1	5
24	R:R:F182	R:R:Y183	26.5536	4.13	No	No	0	6	5
25	R:R:F151	R:R:F182	28.5383	7.5	Yes	No	0	7	6
26	R:R:F151	R:R:S361	30.5277	5.28	Yes	No	0	7	7
27	R:R:S361	R:R:Y109	51.8994	5.09	No	No	0	7	7
28	R:R:C358	R:R:Y109	49.7868	9.41	No	No	0	5	7
29	R:R:C358	R:R:V105	48.8158	6.83	No	No	0	5	5
30	R:R:V105	R:R:Y162	48.0248	5.05	No	Yes	0	5	5
31	R:R:Y161	R:R:Y162	33.7391	11.91	Yes	Yes	1	5	5
32	R:R:P106	R:R:Y162	11.8179	4.17	No	Yes	0	6	5
33	R:R:S361	R:R:V112	42.644	4.85	No	No	0	7	7
34	R:R:C365	R:R:V112	42.1703	5.12	Yes	No	0	8	7
35	R:R:L117	R:R:V149	36.4437	1.49	Yes	No	0	6	7
36	R:R:L150	R:R:V149	37.9595	1.49	No	No	0	6	7
37	R:R:L150	R:R:N185	39.4799	6.87	No	No	0	6	8
38	R:R:F151	R:R:N185	46.6607	4.83	Yes	No	0	7	8
39	R:R:L117	R:R:V152	34.0375	2.98	Yes	No	0	6	6
40	R:R:S116	R:R:V152	33.5402	3.23	No	No	0	8	6
41	R:R:N120	R:R:S116	33.0618	4.47	No	No	0	9	8
42	R:R:N120	R:R:P368	31.1861	9.77	No	No	0	9	9
43	R:R:P368	R:R:Y372	29.7651	4.17	No	Yes	0	9	6
44	R:R:F127	R:R:Y372	17.6629	6.19	Yes	Yes	5	6	6
45	R:R:F127	R:R:V126	10.5769	2.62	Yes	No	0	6	7
46	R:R:A219	R:R:P136	12.4005	1.87	No	No	0	7	6
47	R:R:A219	R:R:Y140	16.3651	5.34	No	Yes	0	7	7
48	R:R:I196	R:R:Y140	40.1809	4.84	No	Yes	0	9	7
49	R:R:I196	R:R:R200	40.953	5.01	No	No	0	9	9
50	R:R:R200	R:R:Y371	61.9837	6.17	No	No	0	9	9
51	R:R:M193	R:R:Y371	100	8.38	Yes	No	0	8	9
52	R:R:F322	R:R:M193	61.8369	4.98	No	Yes	0	9	8
53	R:R:F322	R:R:L283	61.7753	3.65	No	No	0	9	6
54	R:R:F279	R:R:L283	61.8084	6.09	Yes	No	0	8	6
55	R:R:F279	R:R:N330	62.069	24.17	Yes	No	0	8	8
56	R:R:N330	R:R:Y187	33.0902	9.3	No	Yes	0	8	8
57	R:R:F274	R:R:Y187	26.5441	17.54	Yes	Yes	6	5	8
58	R:R:F274	R:R:Y270	27.212	8.25	Yes	Yes	0	5	5
59	R:R:F271	R:R:Y270	24.8958	13.41	Yes	Yes	0	5	5
60	R:R:C223	R:R:Y140	21.5186	4.03	No	Yes	0	7	7
61	R:R:C223	R:R:H143	20.576	16.22	No	No	0	7	9
62	R:R:L144	R:R:L192	16.9335	4.15	No	No	0	9	7
63	R:R:L144	R:R:Y372	17.4403	8.21	No	Yes	0	9	6
64	R:R:F151	R:R:M186	16.1898	4.98	Yes	No	0	7	7
65	R:R:M186	R:R:Y187	16.1614	9.58	No	Yes	0	7	8
66	R:R:F170	R:R:W168	13.4473	20.04	Yes	Yes	0	7	9
67	R:R:W168	R:R:Y161	26.2931	9.65	Yes	Yes	1	9	5
68	R:R:C175	R:R:W168	10.1127	10.45	No	Yes	1	9	9
69	R:R:V234	R:R:Y270	14.6646	2.52	No	Yes	0	6	5
70	R:R:F326	R:R:M193	42.0424	3.73	Yes	Yes	0	9	8
71	R:R:C325	R:R:F326	39.712	5.59	Yes	Yes	2	8	9
72	R:R:C325	R:R:I366	39.7025	1.64	Yes	No	2	8	7
73	R:R:C365	R:R:I366	40.8062	1.64	Yes	No	0	8	7
74	R:R:R200	R:R:Y290	47.7501	7.2	No	Yes	0	9	8
75	R:R:S197	R:R:Y290	49.7916	5.09	No	Yes	0	9	8
76	R:R:S197	R:R:S286	11.2685	6.52	No	No	0	9	8
77	R:R:V318	R:R:Y371	41.2277	5.05	No	No	0	8	9
78	R:R:V318	R:R:Y290	36.8037	6.31	No	Yes	0	8	8
79	R:R:C289	R:R:S197	37.2584	5.16	No	No	0	7	9
80	R:R:C289	R:R:F201	33.0049	5.59	No	Yes	0	7	8
81	R:R:F201	R:R:L202	15.7114	3.65	Yes	No	0	8	6
82	R:R:L202	R:R:W213	13.4947	3.42	No	No	0	6	3
83	R:R:L333	R:R:Y353	32.9055	16.41	No	Yes	0	5	5
84	R:R:L333	R:R:S275	32.7491	4.5	No	No	0	5	5
85	R:R:I294	R:R:S315	22.1154	4.64	No	No	0	4	7
86	R:R:S315	R:R:Y290	24.2042	2.54	No	Yes	0	7	8
87	R:R:I294	R:R:L312	19.9318	4.28	No	No	0	4	5
88	R:R:L297	R:R:L312	15.5078	2.77	Yes	No	0	8	5
89	R:R:I334	R:R:S275	10.539	3.1	No	No	0	5	5
90	R:R:N330	R:R:S275	36.6521	5.96	No	No	0	8	5
91	R:R:H143	R:R:L192	16.9003	3.86	No	No	0	9	7
92	R:R:P236	R:R:Y270	12.9026	13.91	No	Yes	0	7	5
93	R:R:D256	R:R:T253	10.9085	4.34	No	No	1	4	3
94	R:R:D256	R:R:Y162	11.7942	5.75	No	Yes	1	4	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8XOS_nogp

PDB Summary
PDB	8XOS_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.65
Number of Linked Nodes	278
Number of Links	298
Number of Hubs	35
Number of Links mediated by Hubs	135
Number of Communities	8
Number of Nodes involved in Communities	33
Number of Links involved in Communities	37

Path Summary
Number Of Nodes in MetaPath	95
Number Of Links MetaPath	94
Number of Shortest Paths	53214
Length Of Smallest Path	3
Average Path Length	14.7618
Length of Longest Path	30
Minimum Path Strength	1.49
Average Path Strength	6.53005
Maximum Path Strength	18.515
Minimum Path Correlation	0.7
Average Path Correlation	0.926161
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	49.015
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.2812
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• negative regulation of protein transport • regulation of systemic arterial blood pressure by renin-angiotensin • regulation of localization • multicellular organismal process • regulation of systemic arterial blood pressure by hormone • establishment of protein localization • system process • regulation of cellular process • regulation of renal system process • regulation of system process • negative regulation of biological process • negative regulation of transport • cell communication • localization • negative regulation of secretion • circulatory system process • renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of biological process • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • regulation of systemic arterial blood pressure by circulatory renin-angiotensin • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of endocrine process • renin secretion into blood stream • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of protein localization • transport • signaling • negative regulation of renin secretion into blood stream • protein localization to extracellular region • regulation of secretion by cell • secretion by cell • regulation of renin secretion into blood stream • signal release • negative regulation of cellular process • regulation of multicellular organismal process • renal system process involved in regulation of systemic arterial blood pressure • blood circulation • negative regulation of protein localization • renal system process • regulation of transport • secretion • regulation of blood pressure • biological regulation • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • endocrine process • regulation of systemic arterial blood pressure • protein transport • macromolecule localization • cellular process • multicellular organismal-level homeostasis • homeostatic process • homeostasis of number of cells within a tissue • anatomical structure homeostasis • tissue homeostasis • homeostasis of number of cells • regulation of tube diameter • regulation of tube size • positive regulation of biological process • positive regulation of vasoconstriction • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • blood vessel diameter maintenance • vasoconstriction • regulation of anatomical structure size • cellular response to stimulus • response to stimulus • thrombin-activated receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • apoptotic process • programmed cell death • positive regulation of cellular process • leukocyte homeostasis • immune system process • dendritic cell homeostasis • regulation of body fluid levels • wound healing • cell activation • hemostasis • blood coagulation • response to stress • coagulation • response to wounding • platelet activation • positive regulation of interleukin-8 production • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • cytokine production • regulation of cytokine production • positive regulation of macromolecule metabolic process • regulation of biosynthetic process • interleukin-8 production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • positive regulation of gene expression • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • regulation of interleukin-8 production • phospholipase C-activating G protein-coupled receptor signaling pathway • regulation of calcium ion transport • positive regulation of calcium ion transport • regulation of monoatomic ion transport • calcium ion transport • metal ion transport • positive regulation of transport • positive regulation of monoatomic ion transport • monoatomic ion transport • monoatomic cation transport • regulation of metal ion transport • positive regulation of coagulation • regulation of response to external stimulus • positive regulation of blood coagulation • regulation of response to wounding • regulation of coagulation • positive regulation of response to stimulus • regulation of response to stress • positive regulation of hemostasis • regulation of hemostasis • positive regulation of response to wounding • regulation of blood coagulation • response to external stimulus • positive regulation of wound healing • regulation of response to stimulus • regulation of wound healing • vesicle organization • cellular component organization • platelet dense granule organization • organelle organization • secretory granule organization • cellular component organization or biogenesis • endomembrane system organization • regulation of interleukin-1 production • interleukin-1 production • regulation of interleukin-1 beta production • interleukin-1 beta production • collagen biosynthetic process • regulation of collagen biosynthetic process • regulation of collagen metabolic process • positive regulation of collagen metabolic process • positive regulation of collagen biosynthetic process • collagen metabolic process • cell junction organization • neuromuscular junction development • establishment of synaptic specificity at neuromuscular junction • synapse organization • positive regulation of cytosolic calcium ion concentration • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of canonical NF-kappaB signal transduction • regulation of signal transduction • intracellular signal transduction • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of intracellular signal transduction • canonical NF-kappaB signal transduction • regulation of cell communication • regulation of canonical NF-kappaB signal transduction • positive regulation of signaling • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • interleukin-6 production • positive regulation of interleukin-6 production • regulation of interleukin-6 production • connective tissue replacement involved in inflammatory response wound healing • wound healing involved in inflammatory response • defense response • inflammatory response to wounding • tissue remodeling • connective tissue replacement • inflammatory response • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • Rho protein signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • positive regulation of small GTPase mediated signal transduction • trans-synaptic signaling • trans-synaptic signaling, modulating synaptic transmission • modulation of chemical synaptic transmission • trans-synaptic signaling by endocannabinoid • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • trans-synaptic signaling by lipid, modulating synaptic transmission • anterograde trans-synaptic signaling • trans-synaptic signaling by lipid • trans-synaptic signaling by endocannabinoid, modulating synaptic transmission • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • developmental process • anatomical structure morphogenesis • anatomical structure development • neuron apoptotic process • negative regulation of neuron apoptotic process • negative regulation of programmed cell death • negative regulation of apoptotic process • regulation of neuron apoptotic process • negative regulation of glomerular filtration • regulation of glomerular filtration • negative regulation of multicellular organismal process • glomerular filtration • renal filtration • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • negative regulation of cell population proliferation • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • calcium ion transmembrane import into cytosol • monoatomic ion transmembrane transport • monoatomic cation transmembrane transport • transmembrane transport • release of sequestered calcium ion into cytosol • calcium ion transmembrane transport • cell surface receptor signaling pathway via STAT • positive regulation of receptor signaling pathway via STAT • positive regulation of receptor signaling pathway via JAK-STAT • regulation of receptor signaling pathway via JAK-STAT • cell surface receptor signaling pathway • regulation of receptor signaling pathway via STAT • cell surface receptor signaling pathway via JAK-STAT • regulation of synaptic plasticity • positive regulation of DNA-templated transcription • RNA metabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • primary metabolic process • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • positive regulation of smooth muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • smooth muscle contraction • regulation of muscle contraction • regulation of smooth muscle contraction • positive regulation of muscle contraction • cell junction maintenance • cellular component maintenance • cell-cell junction maintenance • cell-cell junction organization • positive regulation of cation transmembrane transport • regulation of monoatomic ion transmembrane transport • regulation of calcium ion transmembrane transport • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • positive regulation of monoatomic ion transmembrane transport • positive regulation of release of sequestered calcium ion into cytosol • regulation of release of sequestered calcium ion into cytosol • regulation of transmembrane transport • regulation of monoatomic cation transmembrane transport • biological process involved in interspecies interaction between organisms • response to lipid • response to other organism • response to oxygen-containing compound • response to lipopolysaccharide • response to biotic stimulus • response to bacterium • response to chemical • response to external biotic stimulus • response to molecule of bacterial origin • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • neuromuscular junction • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • neuromuscular junction • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • Golgi apparatus • organelle • cytoplasm • intracellular membrane-bounded organelle • endomembrane system • cell surface • membrane microdomain • membrane raft • plasma membrane raft • caveola • early endosome • endosome • intracellular vesicle • cytoplasmic vesicle • vesicle • extracellular region • platelet dense tubular network • late endosome • protein binding • binding • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • organelle membrane • cell projection membrane • cell body • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • ciliary basal body
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25116
Sequence	>8XOS_nogp_Chain_R S F L L R N P A F I S E D A S G Y L T S S W L T L F V P S V Y T G V F V V S L P L N I M A I V V F I L K M K V K K P A V V Y M L H L A T A D V L F V S V L P F K I S Y Y F S G S D W Q F G S E L C R F V T A A F Y C N M Y A S I L L M T V I S I D R F L A V V Y P M Q S L S W R T L G R A S F T C L A I W A L A I A G V V P L L L K E Q T I Q V P G L N I T T C H D V L N E T L L E G Y Y A Y Y F S A F S A V F F F V P L I I S T V C Y V S I I R C L S S N R S K K S R A L F L S A A V F C I F I I C F G P T N V L L I A H Y S F L S H T S T T E A A Y F A Y L L C V C V S S I S C C I D P L I Y Y Y A S S E C Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	3VW7	A	Peptide	Proteinase Activated	PAR1	Homo sapiens	-	Vorapaxar; Na	-	2.2	2012-12-12	doi.org/10.1038/nature11701
	8XOR	A	Peptide	Proteinase Activated	PAR1	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2024-09-18	doi.org/10.1038/s41422-024-00997-2
	8XOR (No Gprot)	A	Peptide	Proteinase Activated	PAR1	Homo sapiens	-	-		3	2024-09-18	doi.org/10.1038/s41422-024-00997-2
	8XOS	A	Peptide	Proteinase Activated	PAR1	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2024-09-18	doi.org/10.1038/s41422-024-00997-2
	8XOS (No Gprot)	A	Peptide	Proteinase Activated	PAR1	Homo sapiens	-	-		3.2	2024-09-18	doi.org/10.1038/s41422-024-00997-2
	9D4Z	A	Peptide	Proteinase Activated	PAR1	Homo sapiens	-	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.74	2025-05-07	doi.org/10.1038/s41467-025-59138-x
	9D4Z (No Gprot)	A	Peptide	Proteinase Activated	PAR1	Homo sapiens	-	-		2.74	2025-05-07	doi.org/10.1038/s41467-025-59138-x

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