Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x35 3.2575405
21x39 4.85875407
31x54 3.235407
41x55 5.26375404
52x43 4.72518
62x46 4.17419
72x50 5.945519
82x51 3.766507
92x53 6.74571717
102x59 6.945416
112x64 5.92875435
12E1x49 5.4175414
13E1x50 7.73429719
14E1x52 9.901517
153x28 5.0125415
163x29 4.50167616
173x36 6.24375418
183x37 7.636517
193x41 3.60125406
203x43 5.88625418
213x46 4.68625419
223x50 5.39625419
23I2x52 7.28375404
24I2x57 7.112526
254x49 3.99625407
264x57 4.32125407
27E2.T173 2.78125403
28E2x52 10.0513414
29E2.F180 10.0825405
305x39 7.76875415
315x43 8.43333616
325x47 8.13408
335x58 5.92583618
345x65 3.409568
356x44 5.411519
366x48 5.54857719
376x49 5.65875406
386x51 5.459517
397x30 3.26125405
407x42 6.795417
417x45 8.50875419
427x49 7.19875419
437x53 4.415619
447x54 5.0375407
457x55 3.24125407
46Lig 8.576391810
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
11x35 1x39 19.6434.54YesYes057
21x39 7x42 23.25983.75YesYes077
32x53 7x46 21.31897.27YesNo078
42x50 7x46 20.91164.415YesNo098
51x50 2x50 16.745311.445NoYes099
61x50 2x51 12.73484.83NoYes097
72x46 2x50 13.03883.39YesYes199
82x46 7x53 13.26293.515YesYes199
92x43 7x53 40.06353.475YesYes189
102x43 7x54 28.12384.42YesYes087
117x54 7x55 13.34874.585YesYes077
123x36 7x42 16.15684.875YesYes187
136x44 6x48 53.72597.015YesYes199
143x43 6x44 1008.165YesYes189
153x43 7x53 98.24235.44YesYes189
167x54 8x50 12.24763.93YesNo079
172x39 2x43 16.44526.24NoYes078
182x39 I2x57 15.3482.585NoYes076
193x50 7x53 33.55874.12YesYes199
203x36 Lig 20.53165.76YesYes180
213x37 Lig 32.843617.305YesYes170
223x37 3x41 26.19075.895YesYes076
233x41 4x49 20.35622.89YesYes067
243x29 Lig 66.14128.07YesYes160
253x28 3x29 27.58793.93YesYes156
262x59 3x28 13.64687.865YesYes165
273x25 3x29 13.62153.495NoYes196
283x25 E1x50 12.719210.445NoYes199
293x28 E1x50 13.61174.29YesYes159
303x29 E2x50 13.51633.49YesNo169
31E1x50 E2x50 12.719210.445YesNo199
322x63 3x29 15.42994.275NoYes056
332x63 E1x50 12.83033.5NoYes059
34E1x50 E1x52 44.286419.045YesYes197
352x59 E1x52 11.682511.25YesYes167
36E1x51 E1x52 46.51968.67NoYes127
37E1x49 E1x51 32.66435.34YesNo142
38E1x49 E2.T173 23.41186.165YesYes043
39E2x51 Lig 20.38942.995NoYes140
40E2.V167 E2x51 19.56123.175NoNo014
41E2.N179 E2.V167 17.83853.695NoNo041
423x40 Lig 44.62553.415NoYes180
433x50 5x58 35.9447.2YesYes198
443x47 5x58 59.34214.67NoYes098
456x40 7x53 35.89726.31NoYes089
465x58 6x40 32.87865.68YesNo088
473x47 5x57 55.33953.42NoNo098
483x51 5x57 53.33236.025NoNo088
493x51 3x55 51.32123.17NoNo088
50I2x53 I2x57 10.15286.47NoYes256
513x55 5x64 41.20164.935NoNo085
525x36 Lig 12.77384.28NoYes140
53E2.N179 E2.P182 13.02134.075NoNo044
54E2.P182 E2.W183 12.10152.7NoNo041
555x64 5x68 39.16912.71NoNo055
565x68 I3.L233 35.08854.655NoNo052
575x65 I3.L233 33.04236.42YesNo082
585x65 6x33 16.72192.54YesNo687
596x32 6x33 14.66012.88NoNo077
602x53 3x36 11.889110.355YesYes178
616x48 Lig 54.82313.135YesYes190
623x40 6x44 44.5653.275NoYes189
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x533x323.931YesNo7622
2x533x3610.3551YesYes7821
2x537x4213.9351YesYes7722
2x603x293.751NoYes6611
2x603x326.5551NoNo6612
2x60Lig4.31NoYes6010
3x253x293.4951NoYes9621
3x25E2x506.371NoNo9922
3x283x293.931YesYes5621
3x29E2x503.491YesNo6912
3x29Lig8.071YesYes6010
3x333x373.5851NoYes5711
3x334x576.5051NoYes5712
3x33Lig16.961NoYes5010
3x366x483.9851YesYes8911
3x367x424.8751YesYes8712
3x36Lig5.761YesYes8010
3x373x415.8951YesYes7612
3x374x569.1351YesNo7512
3x37Lig17.3051YesYes7010
3x406x443.2751NoYes8912
3x406x485.5151NoYes8911
3x40Lig3.4151NoYes8010
4x574x613.9650YesNo7422
4x614x655.610NoNo4521
4x65E2x529.181NoYes5411
4x65Lig3.0251NoYes5010
E2.V167E2x513.1750NoNo1421
E2x51Lig2.9951NoYes4010
E2.F180E2x5213.3950YesYes5421
5x39E2x5210.1551YesYes5411
E2x52Lig7.4751YesYes4010
5x36E2.F1804.261NoYes4512
5x36E3.I2685.711NoNo4312
5x395x435.331YesYes5611
5x39Lig13.431YesYes5010
5x405x433.750NoYes5621
5x436x525.8451YesNo6812
5x436x553.4551YesNo6612
5x43Lig28.1051YesYes6010
6x446x487.0151YesYes9921
6x447x453.6251YesYes9922
6x486x523.8351YesNo9812
6x487x415.1851YesNo9812
6x487x4510.171YesYes9912
6x48Lig3.1351YesYes9010
6x517x375.621YesNo7712
6x517x385.091YesNo7612
6x517x4141YesNo7812
6x51Lig8.471YesYes7010
7x387x424.620NoYes6722
5x36Lig4.281NoYes4010
2x633x294.2750NoYes5621
5x436x514.1151YesYes6711
6x58Lig2.771NoYes4010
7x34Lig2.621NoYes5010
6x587x302.4351NoYes4512
3x375x4612.261YesNo7612
4x605x392.160NoYes8521
7x317x340.920NoNo4521

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
75.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
75.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
68.42Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
66.67Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
65.00Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
63.16Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
60.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
58.82Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
57.14Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
57.14Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
55.56Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
55.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
52.94Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
52.17Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
50.00Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
50.00Consensussst_onOrthosteric Ligandsst2_on sst4_on
47.06Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
45.83Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
45.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
45.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
44.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
44.00Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
42.86Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
42.86Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
42.86Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
42.86Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
42.86Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
42.86Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
42.86Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
42.86Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
41.67Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
40.91Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
40.91Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
40.91Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
40.91Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
40.91Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
40.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
40.00Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
40.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
40.00Consensusangiotensin_onOrthosteric Ligandat1_on
40.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
40.00Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
39.13Single7XN9L-054,5227XN9-SST2-L-054,522
39.13Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
39.13Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
38.46Single6JODAngiotensin II6JOD-AT2-Angiotensin II
38.46Single7C61Ergotamine7C61-5-HT1B-Ergotamine
38.46Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
38.46Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
38.10Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
38.10Single4RWADIPP-NH24RWA-δ-DIPP-NH2
38.10Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
38.10Single5V54Methiothepin5V54-5-HT1B-Methiothepin
38.10Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
38.10Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
38.10Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
38.10Consensus5ht1_offOrthosteric Ligand5ht1b_off
38.10Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
38.10Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
38.10Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
38.10Consensuschemerin_onOrthosteric Ligandcml1_on
38.10Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
38.10Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
38.10Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
37.50Single4IARErgotamine4IAR-5-HT1B-Ergotamine
37.50Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
37.50Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
37.50Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
37.04Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
37.04Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
37.04Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
37.04Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
36.84Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
36.67Single5GLHEndothelin-15GLH-ETB-Endothelin-1
36.36Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
36.36Single6A93Risperidone6A93-5-HT2A-Risperidone
36.36Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
36.36Single6MXTSalmeterol6MXT-β2-Salmeterol
36.36Single7DFPSpiperone7DFP-D2-Spiperone
36.36Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
36.36Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
36.36Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.36Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
36.36Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
36.36Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
36.36Single7YITNalfurafine7YIT-κ-Nalfurafine
36.36Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
36.36Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
36.36Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
36.36Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
36.36Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.36Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
36.36Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
36.36Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
36.36Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
36.36Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
36.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
36.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
36.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
36.00Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
35.29Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
35.00Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
35.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
35.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
35.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
35.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
35.00Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
35.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
35.00Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
34.78Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
34.78Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
34.78Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
34.78Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
34.78Single7EZCUKA7EZC-A2A-UKA
34.78Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
34.78Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
34.78Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
34.78Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
34.78Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
34.78Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
34.78Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
34.78Consensusendothelin_offOrthosteric Ligandetb_off
34.78Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
34.78Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
34.78Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
34.62Single5WF5UK-4320975WF5-A2A-UK-432097
34.62Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
34.62Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
34.48Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
33.33Single4NTJAZD12834NTJ-P2Y12-AZD1283
33.33Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
33.33Single5WF6UK-4320975WF6-A2A-UK-432097
33.33Single5ZTYAM102575ZTY-CB2-AM10257
33.33Single6IGLIRL16206IGL-ETB-IRL1620
33.33Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
33.33Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
33.33Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
33.33Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
33.33Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
33.33Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
33.33Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
33.33Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
33.33Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
33.33Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
33.33Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
33.33Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
33.33Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
33.33Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
33.33Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
33.33Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
33.33Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
33.33Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
33.33Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Consensuslpl_onOrthosteric Ligands1p_on lpa_on
33.33Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
33.33Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
33.33Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
32.26Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
32.14Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
32.14Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
32.14Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
32.14Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.00Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
32.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
32.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
32.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
32.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
32.00Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
32.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
32.00Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
32.00Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
32.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
31.82Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
31.82Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
31.82Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
31.82Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
31.82Single5X93K-87945X93-ETB-K-8794
31.82Single6J20Aprepitant6J20-NK1-Aprepitant
31.82Single6J21Aprepitant6J21-NK1-Aprepitant
31.82Single7B6WCyclazosin7B6W-α1b-Cyclazosin
31.82Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
31.82Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
31.82Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
31.82Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
31.82Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
31.82Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
31.82Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
31.82Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
31.82Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
31.82Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
31.82Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.82Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
31.82Single8E0GBU728E0G-μ-BU72
31.82Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
31.82Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
31.82Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
31.82Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
31.82Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
31.82Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
31.82Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
31.82Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
31.82Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
31.82Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
31.82Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
31.82Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
31.58Single6AKYMaraviroc6AKY-CCR5-Maraviroc
31.58Single6B73PubChem 1319551386B73-κ-PubChem 131955138
31.58Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
31.58Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
31.58Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
31.58Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
31.03Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
31.03Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
31.03Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Single3QAKUK-4320973QAK-A2A-UK-432097
30.77Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
30.77Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
30.77Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
30.77Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
30.77Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
30.77Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
30.77Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
30.43Single4AMIBucindolol4AMI-β1-Bucindolol
30.43Single4PY02MeSATP4PY0-P2Y12-2MeSATP
30.43Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
30.43Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
30.43Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
30.43Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
30.43Single6ZG4HTL00099366ZG4-M1-HTL0009936
30.43Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
30.43Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
30.43Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
30.43Single7K15MKD0467K15-BLT1-MKD046-Na
30.43Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
30.43Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
30.43Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
30.43Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
30.43Single8JJLOlodaterol8JJL-β2-Olodaterol
30.43Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
30.43Single8WU1KCA8WU1-CB1-KCA-Arrestin1
30.43Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
30.43Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
30.43Consensusblt_offOrthosteric Ligandblt1_off
30.43Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
30.43Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
30.43Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
30.43Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
30.43Consensusdp_offOrthosteric Liganddp2_off
30.43Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
30.43Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
30.43Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
30.43Consensusgs_steroidOrthosteric Ligandgs_bileacid
30.43Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
30.43Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
30.43Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
30.30Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
30.00Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
30.00Single4MBSMaraviroc4MBS-CCR5-Maraviroc
30.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
30.00Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
30.00Single6A94Zotepine6A94-5-HT2A-Zotepine
30.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
30.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
30.00Single6TPNHTL66416TPN-OX2-HTL6641
30.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
30.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
30.00Single8GGTEpinephrine8GGT-β2-Epinephrine
30.00Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.00Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
30.00Consensusendothelin_onOrthosteric Ligandetb_on eta_on
30.00Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
30.00Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
29.63Single6PT2KGCHM076PT2-δ-KGCHM07
29.63Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
29.63Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
29.63Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
29.63Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
29.63Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
29.41Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
29.41Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
29.17Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
29.17Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
29.17Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
29.17Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
29.17Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
29.17Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
29.17Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
29.17Single7UM4AS26747237UM4-5-HT5A-AS2674723
29.17Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
29.17Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
29.17Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
29.17Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
29.17Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
29.17Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
29.17Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
29.17Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
29.17Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
29.17Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
29.17Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.17Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.17Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
29.17Consensusorexin_onOrthosteric Ligandox2_on
29.17Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
29.17Consensussteroid_onOrthosteric Ligandbileacid_on
29.03Single8IY6Endothelin-18IY6-ETB-Endothelin-1
29.03Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.03Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
28.57Single2Y04Salbutamol2Y04-β1-Salbutamol
28.57Single3NY8ICI 118-5513NY8-β2-ICI 118-551
28.57Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
28.57Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
28.57Single4EJ4Naltrindole4EJ4-δ-Naltrindole
28.57Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
28.57Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
28.57Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
28.57Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
28.57Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
28.57Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
28.57Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
28.57Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
28.57Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
28.57Single7UL4Alvimopan7UL4-μ-Alvimopan
28.57Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
28.57Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
28.57Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
28.57Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
28.57Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
28.57Single7WC7Lisuride7WC7-5-HT2A-Lisuride
28.57Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
28.57Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
28.57Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
28.57Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
28.57Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
28.57Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
28.57Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
28.57Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
28.57Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
28.57Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
28.57Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
28.57Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
28.57Single8X64Desloratadine8X64-H1-Desloratadine
28.57Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
28.57Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
28.57Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
28.57Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
28.57Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
28.57Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
28.57Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
28.57Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
28.57Consensusblt_onOrthosteric Ligandblt1_on
28.57Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
28.57Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
28.57Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
28.57Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
28.57Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
28.57Consensusgi_hcarOrthosteric Ligandgi_hca
28.57Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
28.57Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
28.57Consensusleuko_onOrthosteric Ligandblt_on
28.57Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
28.12Single6IGKEndothelin-36IGK-ETB-Endothelin-3
28.00Single3NY9PubChem 9131033NY9-β2-PubChem 913103
28.00Single4UG2CGS216804UG2-A2A-CGS21680
28.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
28.00Single6PT3DPI-2876PT3-δ-DPI-287
28.00Single7SK9CCX6627SK9-ACKR3-CCX662
28.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.00Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
28.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
28.00Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
28.00Single8X5YAstemizole8X5Y-H1-Astemizole
28.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
28.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
28.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
27.78Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
27.78Single6ME5Agomelatine6ME5-MT1-Agomelatine
27.78Single6ME9Ramelteon6ME9-MT2-Ramelteon
27.78Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
27.78Single8GGREpinephrine8GGR-β2-Epinephrine
27.78Single8GGZEpinephrine8GGZ-β2-Epinephrine
27.78Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
27.78Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
27.78Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
27.59Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
27.59Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
27.59Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.59Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.59Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.59Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
27.27Single2Y03Isoprenaline2Y03-β1-Isoprenaline
27.27Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
27.27Single5C1MBU725C1M-μ-BU72
27.27Single5TVNLSD5TVN-5-HT2B-LSD
27.27Single5WIUNemonapride5WIU-D4-Nemonapride
27.27Single5WIVNemonapride5WIV-D4-Nemonapride-Na
27.27Single5WQCEMPA5WQC-OX2-EMPA
27.27Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
27.27Single5XPRBosentan5XPR-ETB-Bosentan
27.27Single6D26Fevipiprant6D26-DP2-Fevipiprant
27.27Single6PS6Timolol6PS6-β2-Timolol
27.27Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
27.27Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
27.27Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
27.27Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
27.27Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
27.27Single7XKAEpinephrine7XKA-β2-Epinephrine
27.27Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
27.27Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
27.27Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
27.27Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
27.27Single8QOTNanobody E8QOT-μ-Nanobody E
27.27Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.27Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
27.27Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
27.27Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
27.27Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
27.27Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
27.27Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
27.27Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
27.27Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
27.27Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
27.27Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
27.27Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
27.27Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
27.27Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
26.92Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
26.92Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
26.92Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
26.92Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
26.92Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
26.92Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
26.92Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
26.92Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
26.92Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.67Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
26.67Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.67Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.67Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
26.67Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
26.32Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
26.32Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
26.32Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
26.32Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8GGSEpinephrine8GGS-β2-Epinephrine
26.32Single8GGYEpinephrine8GGY-β2-Epinephrine
26.32Single8GH1Epinephrine8GH1-β2-Epinephrine
26.32Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
26.09Single2YDVNECA2YDV-A2A-NECA
26.09Single3P0GBI1671073P0G-β2-BI167107
26.09Single4DJHJDTic4DJH-κ-JDTic
26.09Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
26.09Single4U15Tiotropium4U15-M3-Tiotropium
26.09Single4UHRCGS216804UHR-A2A-CGS21680
26.09Single5G53NECA5G53-A2A-NECA-Gs
26.09Single5TZR-5TZR-FFA1 (GPR40)-MK8666
26.09Single5XR8AM8415XR8-CB1-AM841
26.09Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
26.09Single6E59L-7607356E59-NK1-L-760735
26.09Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
26.09Single6H7JIsoprenaline6H7J-β1-Isoprenaline
26.09Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
26.09Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
26.09Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
26.09Single6OL9Tiotropium6OL9-M5-Tiotropium
26.09Single6TQ7SB-3348676TQ7-OX1-SB-334867
26.09Single6WGTLSD6WGT-5-HT2A-LSD
26.09Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
26.09Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
26.09Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
26.09Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
26.09Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
26.09Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
26.09Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
26.09Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
26.09Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
26.09Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
26.09Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
26.09Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
26.09Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
26.09Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
26.09Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
26.09Consensus5ht5_offOrthosteric Ligand5ht5a_off
26.09Consensusa2_onOrthosteric Liganda2a_on a2b_on
26.09Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
26.09Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
26.09Consensuscck_onOrthosteric Ligandccka_on cckb_on
26.09Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
26.09Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
26.09Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
26.09Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
26.09Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
26.09Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
26.09Consensushistamine_offOrthosteric Ligandh1_off
26.09Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
26.09Consensuslpa_offOrthosteric Ligandlpa1_off
26.09Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
26.09Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
26.09Consensusrelaxin_onOrthosteric Ligandrxfp4_on
25.93Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
25.93Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
25.93Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
25.93Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
25.93Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
25.93Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
25.81Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
25.81Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
25.81Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
25.81Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
25.71Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.71Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
25.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
25.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
25.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
25.00Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
25.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
25.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
25.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
25.00Single3OE0CVX153OE0-CXCR4-CVX15
25.00Single4LDEBI1671074LDE-β2-BI167107
25.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
25.00Single5CXVTiotropium5CXV-M1-Tiotropium
25.00Single6AKXA4R6AKX-CCR5-A4R
25.00Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
25.00Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
25.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
25.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
25.00Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
25.00Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
25.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
25.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
25.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
25.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
25.00Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
25.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
25.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
25.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
25.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
25.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
25.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
25.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
25.00Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GGVEpinephrine8GGV-β2-Epinephrine
25.00Single8GGWEpinephrine8GGW-β2-Epinephrine
25.00Single8GGXEpinephrine8GGX-β2-Epinephrine
25.00Single8GH0Epinephrine8GH0-β2-Epinephrine
25.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
25.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
25.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
25.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
25.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
25.00Single8JJ8Formoterol8JJ8-β2-Formoterol
25.00Single8JWZAB9288JWZ-A2A-AB928-Na
25.00Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
25.00Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
25.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
25.00Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
25.00Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
25.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
25.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
25.00Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
25.00Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
25.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
25.00Consensusgt_class-aOrthosteric Ligandgt_opsin
25.00Consensusgt_opsinOrthosteric Ligandgt_sensory
25.00Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
25.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
25.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
25.00Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
25.00Consensusnts_offOrthosteric Ligandnts1_off
25.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
24.24Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
24.24Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
24.14Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
24.14Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
24.14Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.14Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
24.14Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
24.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
24.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
24.00Single6IBLArformoterol6IBL-β1-Arformoterol
24.00Single6K1QIRL25006K1Q-ETB-IRL2500
24.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
24.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
24.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
24.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
24.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
24.00Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
24.00Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
24.00Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
24.00Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
24.00Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
23.81Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
23.81Single3RZECidoxepin3RZE-H1-Cidoxepin
23.81Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
23.81Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
23.81Single4ZJCSB-6740424ZJC-OX1-SB-674042
23.81Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
23.81Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
23.81Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
23.81Single6MH8ZM2413856MH8-A2A-ZM241385
23.81Single6PS4ICI 118-5516PS4-β2-ICI 118-551
23.81Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
23.81Single6TPGEMPA6TPG-OX2-EMPA
23.81Single6TPKRetosiban6TPK-OT-Retosiban
23.81Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
23.81Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
23.81Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
23.81Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
23.81Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
23.81Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
23.81Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
23.81Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
23.81Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
23.81Single7T32ZM2413857T32-A2A-ZM241385
23.81Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
23.81Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
23.81Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
23.81Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
23.81Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
23.81Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
23.81Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
23.81Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
23.81Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
23.81Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
23.81Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
23.81Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
23.81Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.81Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.81Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.81Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.81Single8GGIEpinephrine8GGI-β2-Epinephrine
23.81Single8GGKEpinephrine8GGK-β2-Epinephrine
23.81Single8GGLEpinephrine8GGL-β2-Epinephrine
23.81Single8GGMEpinephrine8GGM-β2-Epinephrine
23.81Single8GGPEpinephrine8GGP-β2-Epinephrine
23.81Single8GGQEpinephrine8GGQ-β2-Epinephrine
23.81Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
23.81Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
23.81Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
23.81Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
23.81Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
23.81Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
23.81Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.81Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.81Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
23.81Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.81Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.81Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
23.81Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
23.81Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
23.81Consensus5ht5_onOrthosteric Ligand5ht5a_on
23.81Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
23.81Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
23.81Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
23.81Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
23.81Consensushca_onOrthosteric Ligandhca2_on hca3_on
23.81Consensushcar_onOrthosteric Ligandhca_on
23.81Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
23.81Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
23.81Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
23.81Consensusvasopressin-ot_offOrthosteric Ligandot_off
23.33Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.33Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
23.33Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
23.33Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
23.33Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
23.33Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Single6KNMJN241-96KNM-Apelin-JN241-9
23.08Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
23.08Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
23.08Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
23.08Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
23.08Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
23.08Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
23.08Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
23.08Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
23.08Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
23.08Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
23.08Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
22.73Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
22.73Single2Y02Carmoterol2Y02-β1-Carmoterol
22.73Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
22.73Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
22.73Single4MQSIperoxo4MQS-M2-Iperoxo
22.73Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
22.73Single4U14Tiotropium4U14-M3-Tiotropium
22.73Single4YAYZD-71554YAY-AT1-ZD-7155
22.73Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
22.73Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
22.73Single6D27CAY104716D27-DP2-CAY10471
22.73Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
22.73Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
22.73Single6H7MSalbutamol6H7M-β1-Salbutamol
22.73Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
22.73Single6PS1Timolol6PS1-β2-Timolol
22.73Single6TOTLemborexant6TOT-OX1-Lemborexant
22.73Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
22.73Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
22.73Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
22.73Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
22.73Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
22.73Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
22.73Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
22.73Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
22.73Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
22.73Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
22.73Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
22.73Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
22.73Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
22.73Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.73Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
22.73Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
22.73Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.73Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.73Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.73Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.73Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.73Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.73Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.73Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.73Single8GGJEpinephrine8GGJ-β2-Epinephrine
22.73Single8GGNEpinephrine8GGN-β2-Epinephrine
22.73Single8GGOEpinephrine8GGO-β2-Epinephrine
22.73Single8GGUEpinephrine8GGU-β2-Epinephrine
22.73Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
22.73Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
22.73Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
22.73Single8JJOAlprenolol8JJO-β2-Alprenolol
22.73Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
22.73Single8K5DGSK2560738K5D-HCA2-GSK256073
22.73Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
22.73Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.73Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.73Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.73Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
22.73Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
22.73Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
22.73Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single8X63Mepyramine8X63-H1-Mepyramine
22.73Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
22.73Consensusadenosine_onOrthosteric Liganda1_on a2_on
22.73Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
22.73Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
22.73Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
22.73Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
22.73Consensuscck_offOrthosteric Ligandccka_off
22.73Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
22.73Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
22.73Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.73Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
22.73Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
22.73Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
22.73Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
22.73Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
22.73Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
22.73Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
22.73Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
22.73Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
22.73Consensusnucleotide_onOrthosteric Ligandadenosine_on
22.73Consensustachykinin_offOrthosteric Ligandnk1_off
22.73Consensustar_onOrthosteric Ligandta1_on
22.58Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
22.58Single7SK3CXCL127SK3-ACKR3-CXCL12
22.58Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
22.58Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
22.58Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
22.58Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
22.58Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
22.22Single4XT1Fractalkine4XT1-US28-Fractalkine
22.22Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
22.22Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
22.22Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
22.22Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
22.22Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
22.22Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
22.22Consensussensory_onOrthosteric Ligandopsin_on
21.88Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
21.88Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
21.88Consensusgo_class-b1Orthosteric Ligandgo_crf
21.88Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
21.74Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
21.74Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
21.74Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
21.74Single5N2SPSB365N2S-A1-PSB36
21.74Single5NM2ZM2413855NM2-A2A-ZM241385-Na
21.74Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
21.74Single6E67BI1671076E67-β2-BI167107-Gs (fused)
21.74Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
21.74Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
21.74Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
21.74Single6LUQHaloperidol6LUQ-D2-Haloperidol
21.74Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
21.74Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
21.74Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
21.74Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
21.74Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
21.74Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
21.74Single6TP6Filorexant6TP6-OX1-Filorexant
21.74Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
21.74Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
21.74Single7C4SS1P7C4S-S1P3-S1P
21.74Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
21.74Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
21.74Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
21.74Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
21.74Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
21.74Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
21.74Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
21.74Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.74Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
21.74Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Single8EA0Iperoxo8EA0-M3-Iperoxo
21.74Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
21.74Single8GNEKW-63568GNE-A2A-KW-6356-Na
21.74Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
21.74Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
21.74Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
21.74Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
21.74Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
21.74Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
21.74Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
21.74Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
21.74Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
21.74Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
21.74Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
21.74Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
21.74Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
21.74Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
21.74Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
21.74Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
21.74Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
21.74Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
21.74Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
21.74Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.43Single6HLOAprepitant6HLO-NK1-Aprepitant
21.43Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
21.43Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
21.43Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
21.43Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
21.43Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
21.43Consensussst_offOrthosteric Ligandsst2_off
21.43Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
21.21Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
21.21Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
21.21Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
21.05Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
21.05Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
21.05Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
21.05Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
21.05Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
21.05Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
21.05Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
21.05Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
20.83Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
20.83Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
20.83Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
20.83Single6OS1TRV0266OS1-AT1-TRV026
20.83Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
20.83Single7PX4PSB-21137PX4-A2A-PSB-2113
20.83Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
20.83Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
20.83Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
20.83Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
20.83Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
20.83Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
20.83Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
20.83Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
20.83Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
20.83Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
20.83Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
20.83Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
20.83Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
20.83Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
20.83Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
20.83Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
20.83Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
20.83Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
20.83Consensuslpa_onOrthosteric Ligandlpa1_on
20.83Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
20.83Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
20.83Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
20.83Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
20.69Single6W25SHU91196W25-MC4-SHU9119-Ca
20.69Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single7XNACYN1548067XNA-SST2-CYN154806
20.69Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
20.69Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
20.59Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
20.59Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.51Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
20.51Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
20.00Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
20.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
20.00Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
20.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
20.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
20.00Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
20.00Single3OE9IT1t3OE9-CXCR4-IT1t
20.00Single3PBLEticlopride3PBL-D3-Eticlopride
20.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
20.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
20.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
20.00Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
20.00Single6CM4Risperidone6CM4-D2-Risperidone
20.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
20.00Single6HLLCP999946HLL-NK1-CP99994
20.00Single6HLPNetupitant6HLP-NK1-Netupitant
20.00Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
20.00Single6OS2TRV0266OS2-AT1-TRV026
20.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
20.00Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
20.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
20.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
20.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
20.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
20.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
20.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
20.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
20.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
20.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
20.00Single7SRQLSD7SRQ-5-HT2B-LSD
20.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
20.00Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
20.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
20.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
20.00Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
20.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
20.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
20.00Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
20.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
20.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
20.00Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
20.00Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
20.00Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
20.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
20.00Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
20.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
20.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
20.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
20.00Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
20.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
20.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
20.00Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
20.00Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
20.00Consensusclass-t_onOrthosteric Ligandtaste2_on
20.00Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
20.00Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
20.00Consensusgi_class-fOther Ligandgi_frizzled
20.00Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
20.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
20.00Consensusgs_class-tOrthosteric Ligandgs_taste
20.00Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
20.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
20.00Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
20.00Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
20.00Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
19.44Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
19.35Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
19.35Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
19.35Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.35Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single4BUONeurotensin4BUO-NTS1-Neurotensin
19.23Single6H7LDobutamine6H7L-β1-Dobutamine
19.23Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
19.23Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
19.23Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
19.23Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
19.23Consensuscyslt_offOrthosteric Ligandcyslt2_off
19.23Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
19.23Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
19.05Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
19.05Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
19.05Single5WS3EMPA5WS3-OX2-EMPA
19.05Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
19.05Single6KUXRS-799486KUX-α2a-RS-79948
19.05Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
19.05Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
19.05Single6TODEMPA6TOD-OX1-EMPA-Na
19.05Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
19.05Single7BR3Elagolix7BR3-GnRH1-Elagolix
19.05Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
19.05Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
19.05Single7F8YDevazepide7F8Y-CCKA-Devazepide
19.05Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
19.05Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
19.05Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
19.05Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
19.05Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
19.05Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
19.05Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
19.05Single7XRRLemborexant7XRR-OX2-Lemborexant
19.05Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
19.05Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
19.05Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
19.05Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
19.05Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
19.05Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
19.05Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
19.05Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GNGIstradefylline8GNG-A2A-Istradefylline
19.05Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
19.05Single8IHKAcifran8IHK-HCA3-Acifran
19.05Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single8IWESpermidine8IWE-TAAR9-Spermidine
19.05Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
19.05Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
19.05Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
19.05Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
19.05Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
19.05Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
19.05Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
19.05Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
19.05Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
19.05Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
18.92Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
18.92Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
18.75Single4XT3Fractalkine4XT3-US28-Fractalkine
18.75Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
18.75Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
18.75Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.75Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
18.75Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
18.75Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
18.52Single5EE7MK08935EE7-Glucagon-MK0893
18.52Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
18.52Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
18.52Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
18.52Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
18.52Consensusclass-d_offOrthosteric Ligandste2_off
18.52Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
18.52Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
18.52Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
18.42Consensuspth_onOrthosteric Ligandpth1_on pth2_on
18.18Single2YDOAdenosine2YDO-A2A-Adenosine
18.18Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
18.18Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
18.18Single5IU7Q274563465IU7-A2A-Q27456346-Na
18.18Single5JTBZM2413855JTB-A2A-ZM241385
18.18Single5K2BZM2413855K2B-A2A-ZM241385-Na
18.18Single5UVIZM2413855UVI-A2A-ZM241385
18.18Single6AQFZM2413856AQF-A2A-ZM241385
18.18Single6DS0Ly2660976DS0-5-HT2B-Ly266097
18.18Single6FFIMMPEP6FFI-mGlu5-MMPEP
18.18Single6IQLL7458706IQL-D4-L745870
18.18Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
18.18Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
18.18Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
18.18Single6V9SGTPL114036V9S-OX1-GTPL11403
18.18Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
18.18Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
18.18Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
18.18Single6ZG9GSK10347026ZG9-M1-GSK1034702
18.18Single6ZINSR486926ZIN-NTS1-SR48692
18.18Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
18.18Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
18.18Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
18.18Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
18.18Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
18.18Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
18.18Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
18.18Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
18.18Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
18.18Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
18.18Single7VODCariprazine7VOD-5-HT2A-Cariprazine
18.18Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
18.18Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
18.18Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
18.18Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
18.18Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
18.18Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
18.18Single8K5CAcipimox8K5C-HCA2-Acipimox
18.18Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
18.18Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
18.18Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
18.18Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
18.18Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
18.18Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
18.18Consensusgnrh_offOrthosteric Ligandgnrh1_off
18.18Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
18.18Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
18.18Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
18.18Consensuss1p_offOrthosteric Ligands1p1_off
18.18Consensussensory_offOrthosteric Ligandopsin_off
18.18Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.86Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
17.86Single7F8XNN90567F8X-CCKA-NN9056
17.86Single7QA8Peptide7QA8-STE2-Peptide
17.86Single7QA8Peptide7QA8-STE2-Peptide
17.86Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
17.86Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
17.86Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
17.86Consensusclass-d_offOrthosteric Ligandste2_off
17.86Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
17.65Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
17.65Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
17.65Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
17.65Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
17.65Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
17.65Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
17.65Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
17.39Single2Y01Dobutamine2Y01-β1-Dobutamine
17.39Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
17.39Single3EMLZM2413853EML-A2A-ZM241385
17.39Single4DAJTiotropium4DAJ-M3-Tiotropium
17.39Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
17.39Single4EIYZM2413854EIY-A2A-ZM241385-Na
17.39Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
17.39Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
17.39Single5DSGTiotropium5DSG-M4-Tiotropium
17.39Single5IU8Q274563475IU8-A2A-Q27456347-Na
17.39Single5K2AZM2413855K2A-A2A-ZM241385-Na
17.39Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
17.39Single5OLGZM2413855OLG-A2A-ZM241385-Na
17.39Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
17.39Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
17.39Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
17.39Single5VRAZM2413855VRA-A2A-ZM241385-Na
17.39Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
17.39Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
17.39Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
17.39Single6FFHFenobam6FFH-mGlu5-Fenobam
17.39Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
17.39Single6S0LZM2413856S0L-A2A-ZM241385
17.39Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
17.39Single7BU7BI1671077BU7-β1-BI167107
17.39Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
17.39Single7F83PF-051904577F83-Ghrelin-PF-05190457
17.39Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
17.39Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
17.39Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
17.39Single7PYRPSB-21157PYR-A2A-PSB-2115
17.39Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
17.39Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
17.39Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
17.39Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
17.39Single8CU6LJ-45178CU6-A2A-LJ-4517
17.39Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
17.39Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.39Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
17.39Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
17.39Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
17.39Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
17.39Consensusa2_offOrthosteric Liganda2a_off
17.39Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
17.39Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
17.39Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
17.39Consensushistamine_onOrthosteric Ligandh1_on h4_on
17.39Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
17.39Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
17.24Single7SK5CXCL127SK5-ACKR3-CXCL12
17.24Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.14Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.67Single2Y00Dobutamine2Y00-β1-Dobutamine
16.67Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
16.67Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
16.67Single5IUAQ274563485IUA-A2A-Q27456348-Na
16.67Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
16.67Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
16.67Single6LPLZM2413856LPL-A2A-ZM241385-Na
16.67Single6S0QZM2413856S0Q-A2A-ZM241385
16.67Single6WQAZM2413856WQA-A2A-ZM241385-Na
16.67Single6Z4SSR486926Z4S-NTS1-SR48692
16.67Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
16.67Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
16.67Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
16.67Single7RM5ZM2413857RM5-A2A-ZM241385-Na
16.67Single7SINNPS-21437SIN-CaS-NPS-2143
16.67Single7SINNPS-21437SIN-CaS-NPS-2143
16.67Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
16.67Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
16.67Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single7WC4Serotonin7WC4-5-HT2A-Serotonin
16.67Single7WC6LSD7WC6-5-HT2A-LSD
16.67Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.67Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.67Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
16.67Single8FYNZM2413858FYN-A2A-ZM241385-Na
16.67Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
16.67Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
16.67Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
16.67Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
16.67Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
16.67Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
16.28Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
16.22Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
16.13Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
16.13Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
16.13Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
16.13Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
16.00Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
16.00Single5XRAAM115425XRA-CB1-AM11542
16.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
16.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
16.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
16.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
16.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
16.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
16.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
16.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
16.00Single7W41PD1762527W41-BB2-PD176252
16.00Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
16.00Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
16.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
16.00Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
16.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Consensusadenosine_offOrthosteric Liganda1_off a2_off
16.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
16.00Consensusbombesin_offOrthosteric Ligandbb2_off
16.00Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
16.00Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
16.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
15.79Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
15.79Single3RFMCaffeine3RFM-A2A-Caffeine
15.79Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
15.79Single6TQ9SB-4081246TQ9-OX1-SB-408124
15.79Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
15.79Single8A2OTheophylline8A2O-A2A-Theophylline-Na
15.79Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
15.79Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
15.79Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
15.62Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
15.62Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
15.62Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
15.62Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
15.62Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
15.62Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
15.62Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
15.62Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
15.62Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
15.62Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
15.38Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
15.38Single4N4WSANT-14N4W-SMO-SANT-1
15.38Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
15.38Single4XEENeurotensin4XEE-NTS1-Neurotensin
15.38Single4XESNeurotensin4XES-NTS1-Neurotensin
15.38Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
15.38Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
15.38Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
15.38Consensuschemokine_offOrthosteric Ligandcxcr_off
15.38Consensusclass-b2_onOrthosteric Ligandadgrg_on
15.38Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
15.38Consensuscxcr_offOrthosteric Ligandcxcr4_off
15.15Single6FJ3PTH6FJ3-PTH1-PTH
15.15Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.15Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
15.15Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
15.15Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
15.15Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
15.15Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
15.15Consensusclass-d_onOrthosteric Ligandste2_on
15.15Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
15.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
15.00Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
15.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
15.00Single3OE6IT1t3OE6-CXCR4-IT1t
15.00Single3OE8IT1t3OE8-CXCR4-IT1t
15.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
15.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
15.00Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
15.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
15.00Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
15.00Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
15.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
14.81Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
14.81Single5CGDHTL142425CGD-mGlu5-HTL14242
14.81Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
14.81Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
14.81Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
14.71Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.71Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
14.71Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
14.71Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
14.71Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
14.71Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
14.71Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
14.71Consensusgi_class-dOrthosteric Ligandgi_ste
14.71Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.71Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
14.29Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
14.29Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
14.29Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
14.29Single6TP4ACT-4622066TP4-OX1-ACT-462206
14.29Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
14.29Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
14.29Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
14.29Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
14.29Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
14.29Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
14.29Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
14.29Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
14.29Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
14.29Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
14.29Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
14.29Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
14.29Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
14.29Single8K5BNiacin8K5B-HCA2-Niacin
14.29Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
14.29Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
14.29Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
14.29Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
14.29Consensusgo_class-b2Orthosteric Ligandgo_adhesion
14.29Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
14.29Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
14.29Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
14.29Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
13.89Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
13.89Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
13.89Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
13.89Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
13.79Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
13.79Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
13.64Single3ODUIT1t3ODU-CXCR4-IT1t
13.64Single3PWHZM2413853PWH-A2A-ZM241385
13.64Single4S0VSuvorexant4S0V-OX2-Suvorexant
13.64Single5DHHSB-6121115DHH-NOP-SB-612111
13.64Single5K2DZM2413855K2D-A2A-ZM241385
13.64Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
13.64Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
13.64Single6JZHZM2413856JZH-A2A-ZM241385-Na
13.64Single6PS7ZM2413856PS7-A2A-ZM241385-Na
13.64Single6TPJSuvorexant6TPJ-OX2-Suvorexant
13.64Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
13.64Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
13.64Single7F8ULintitript7F8U-CCKA-Lintitript
13.64Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
13.64Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
13.64Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
13.64Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
13.64Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
13.64Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
13.64Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
13.64Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
13.64Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
13.64Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
13.64Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
13.64Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
13.64Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
13.64Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
13.64Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
13.64Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
13.64Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
13.51Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
13.51Consensusglp_onOrthosteric Ligandglp1_on glp2_on
13.33Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
13.33Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
13.33Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
13.33Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
13.16Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
13.16Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
13.16Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
13.04Single3REYPubChem 56973REY-A2A-PubChem 5697
13.04Single5IU4ZM2413855IU4-A2A-ZM241385-Na
13.04Single5IUBQ274563445IUB-A2A-Q27456344-Na
13.04Single5K2CZM2413855K2C-A2A-ZM241385-Na
13.04Single5NLXZM2413855NLX-A2A-ZM241385-Na
13.04Single5NM4ZM2413855NM4-A2A-ZM241385-Na
13.04Single6TP3Nemorexant6TP3-OX1-Nemorexant
13.04Single6VI4JDTic6VI4-κ-JDTic
13.04Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
13.04Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
13.04Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
13.04Single7AROLUF58337ARO-A2A-LUF5833-Na
13.04Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
13.04Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
13.04Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
13.04Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
13.04Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
13.04Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
13.04Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
13.04Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
13.04Single8K2WAMG4878K2W-CXCR3-AMG487
13.04Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
13.04Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
13.04Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
12.90Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
12.82Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
12.50Single5T04Neurotensin5T04-NTS1-Neurotensin
12.50Single5TGZAM65385TGZ-CB1-AM6538
12.50Single5UENDU1725UEN-A1-DU172
12.50Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
12.50Single6GPSMK08126GPS-CCR2-MK0812
12.50Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
12.50Single6LPJZM2413856LPJ-A2A-ZM241385-Na
12.50Single6LPKZM2413856LPK-A2A-ZM241385-Na
12.50Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
12.50Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
12.50Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
12.50Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
12.50Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
12.50Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
12.50Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
12.50Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
12.50Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
12.50Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
12.50Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
12.50Consensusclass-d_onOrthosteric Ligandste2_on
12.50Consensusgi_class-dOrthosteric Ligandgi_ste
12.50Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
12.50Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
12.50Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
12.50Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
12.50Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
12.20Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
12.12Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
12.00Single5CGCHTL142425CGC-mGlu5-HTL14242
12.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
12.00Single6GPXMK08126GPX-CCR2-MK0812
12.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
12.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
12.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
12.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
12.00Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
11.90Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
11.76Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
11.76Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
11.76Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
11.76Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
11.76Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
11.63Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
11.63Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
11.54Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
11.54Single4BV0Neurotensin4BV0-NTS1-Neurotensin
11.54Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
11.54Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
11.54Single7EPENAM5637EPE-mGlu-NAM563
11.54Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
11.54Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
11.54Single7P2L4YI7P2L-mGlu5-4YI
11.54Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.54Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
11.54Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
11.54Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
11.54Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
11.54Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
11.43Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
11.43Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
11.43Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
11.43Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
11.11Single5MZPCaffeine5MZP-A2A-Caffeine-Na
11.11Single5X33BIIL2605X33-BLT1-BIIL260
11.11Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
11.11Single6LMLGlucagon6LML-Glucagon-Glucagon
11.11Single6W25Ca6W25-MC4-SHU9119-Ca
11.11Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
11.11Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
11.11Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
11.11Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
11.11Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
11.11Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
11.11Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
11.11Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
11.11Consensusnts_onOrthosteric Ligandnts1_on
10.81Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
10.71Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
10.71Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
10.71Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
10.71Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
10.53Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
10.53Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
10.53Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
10.53Single8PWNTheophylline8PWN-A2A-Theophylline
10.53Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
10.34Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
10.34Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
10.34Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
10.34Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
10.34Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Consensusgs_class-b2Orthosteric Ligandgs_adgr
10.26Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
10.26Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
10.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
10.00Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
10.00Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
9.76Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
9.76Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
9.68Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
9.68Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Single3UZAGTPL92363UZA-A2A-GTPL9236
9.52Single4XNWMRS25004XNW-P2Y1-MRS2500
9.52Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
9.52Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
9.52Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
9.52Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
9.09Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.09Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
9.09Single7UL2SR486927UL2-NTS1-SR48692-Na
9.09Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
9.09Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
9.09Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
9.09Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
8.89Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
8.82Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
8.82Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
8.70Single4K5YCP-3763954K5Y-CRF1-CP-376395
8.70Single5ZKQABT-4915ZKQ-PAF-ABT-491
8.70Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
8.70Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
8.70Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
8.70Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
8.70Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
8.70Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
8.70Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
8.70Consensusmglu_onOther Ligandmglu2_on mglu4_on
8.70Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
8.33Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
8.33Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single8IYXYL-3658IYX-GPR34-YL-365
8.00Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
8.00Single4Z9GCP-3763954Z9G-CRF1-CP-376395
8.00Single6IIVDaltroban6IIV-TP-Daltroban
8.00Single8GTIBMK-C2058GTI-CRF1-BMK-C205
8.00Consensushcar_offOrthosteric Ligandsuccinate_off
8.00Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
8.00Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
8.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
8.00Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
7.69Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
7.69Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
7.69Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
7.69Single7YXAONO-54306087YXA-S1P5-ONO-5430608
7.69Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
7.69Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
7.69Single8GTGBMK-I1528GTG-CRF1-BMK-I152
7.69Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
7.41Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
7.32Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
7.14Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
7.14Single6IIURamatroban6IIU-TP-Ramatroban
7.14Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
7.14Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
7.14Single8GTMBMK-C2038GTM-CRF1-BMK-C203
7.14Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
7.14Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
7.14Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
6.90Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
6.90Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
6.90Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
6.90Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.90Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
6.90Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.90Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Single7SHEPI; PE7SHE-GPR158-PI; PE
6.25Consensusclass-c_offOther Ligandgabab_off mglu_off
5.88Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
5.88Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
5.41Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
5.26Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
5.13Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
5.00Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
5.00Consensusclass-c_onOther Ligandgabab_on mglu_on
4.88Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.76Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
4.76Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
4.76Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
4.76Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
4.55Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
4.55Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.55Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
4.55Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
4.55Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
4.35Single4O9RCyclopamine4O9R-SMO-Cyclopamine
4.35Single5L7IVismodegib5L7I-SMO-Vismodegib
4.35Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
4.35Consensusgo_proteinOrthosteric Ligandgo_chemokine
4.17Single4BWBNeurotensin4BWB-NTS1-Neurotensin
4.17Single4QINSAG1.54QIN-SMO-SAG1.5
4.17Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
4.17Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
4.17Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
4.17Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
4.17Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
4.17Consensusclass-f_offOrthosteric Ligandsmo_off
4.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.00Single7VV6C48/807VV6-MRGPRX2-C48/80
4.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.00Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
4.00Consensusgi_class-fOrthosteric Ligandgi_frizzled
4.00Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
3.70Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
3.70Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
3.70Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
3.70Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
3.70Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
3.70Consensusep_offOrthosteric Ligandep4_off
3.57Single5V56TC1145V56-SMO-TC114
3.57Single5V57TC1145V57-SMO-TC114
3.57Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
3.57Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
3.45Single7SHEPI; PE7SHE-GPR158-PI; PE
3.45Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
3.33Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
3.33Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
3.23Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.12Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
3.12Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
3.12Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
3.03Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.03Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.56Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.50Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.50Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
2.50Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.50Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
2.44Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.38Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.33Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.33Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.13Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.08Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.08Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.00Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

Consensus Members
Id Members
7VFX 7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
7T6T 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
Net Summary
Imin 2.98
Number of Linked Nodes 288
Number of Links 335
Number of Hubs 46
Number of Links mediated by Hubs 172
Number of Communities 6
Number of Nodes involved in Communities 58
Number of Links involved in Communities 85
Path Summary
Number Of Nodes in MetaPath 63
Number Of Links MetaPath 62
Number of Shortest Paths 103697
Length Of Smallest Path 3
Average Path Length 13.8498
Length of Longest Path 32
Minimum Path Strength 0.8125
Average Path Strength 5.73044
Maximum Path Strength 18.1817
Minimum Path Correlation 0.7
Average Path Correlation 0.924442
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.84615
Average % Of Corr. Nodes 42.916
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 52.7595
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
fpr-alx_onfpr1-alx_on
fpr2-alx_on



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Download fpr1-alx_on.zip



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