Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.S1.02 5.3695125
2G.S1.05 5.88167619
3G.S1.06 5.618754178
4G.H1.01 3.716254179
5G.H1.07 4.545409
6G.S2.08 8.6154135
7G.S3.03 10.214127
8G.S3.04 8.53416
9G.S3.06 8.814515
10G.S3.07 3.8375179
11G.S3.08 4.3175419
12G.s3h2.03 4.7875619
13G.H2.04 5.28875409
14G.H2.06 8.27419
15G.H2.07 5.5475619
16G.h2s4.01 7.89125419
17G.s4h3.01 7.75625447
18G.s4h3.04 5.17643748
19G.H3.01 4.0575199
20G.H3.09 6.291549
21G.H3.17 7.0025615
22G.H3.18 6.508519
23G.S5.03 3.51375408
24G.S5.04 6.455409
25G.S5.05 4.596676189
26G.HG.04 8.18375449
27G.HG.13 3.475547
28G.hgh4.02 6.243336207
29G.hgh4.05 8.65875407
30G.H4.03 4.5325404
31G.H4.10 10.08754206
32G.h4s6.02 5.41625408
33G.h4s6.11 4.88875407
34G.h4s6.12 4.3175404
35G.S6.01 4.46445
36G.S6.02 5.2635217
37G.S6.05 4.61125444
38G.s6h5.01 5.53254189
39G.s6h5.05 3.7825409
40G.H5.08 7.718754138
41G.H5.20 4.985409
42G.H5.26 5.641505
43b.1x4 1.09625408
44b.b1x3 7.24875407
45b.b1x6 10.3212469
46b.l1x3 8.957569
47b.l1x6 11.6187419
48b.b2x1 7.38667618
49b.b2x3 4.7625466
50b.b2x5 10.367567
51b.b3x2 7.5425465
52b.l3x2 3.9625409
53b.b4x2 5.87625408
54b.b4x3 5.588507
55b.b4x4 8.8775468
56b.b4x6 9.56429769
57b.b5x2 5.32256157
58b.b5x3 7.892569
59b.b5x5 6.23754165
60b.b5x7 6.2975407
61b.l5x1 5.2475408
62b.l5x5 7.71667619
63b.b6x5 4.897506
64b.l7x2 4.552519
65b.b8x4 5.913506
66b.l8x3 3.36254233
67b.l8x5 4.74233
68b.l9x3 7.344599
69b.l9x6 4.79857718
70b.b10x3 4.2725408
71b.b10x5 5.233509
72b.l11x2 7.61599
73b.b12x6 8.63333698
74b.b12x7 6.4354249
75b.b13x7 8.646577
76b.l13x3 8.36579
77b.l13x6 6.18519
78b.b14x1 6.79625418
79b.b14x3 5.49375475
80b.b15x1 7.991579
81b.l15x1 5.4425417
82b.l15x2 4.675409
83b.b16x4 9.461576
84b.b16x6 9.14417678
85b.b17x4 5.25254255
86b.l17x3 8.59929739
87b.l17x6 7.9475419
88b.b18x3 5.312538
89b.b18x5 6.8435
90b.l18x1 6.72643756
91b.l18x5 7.41375452
92b.b19x2 7.43429736
93b.b19x4 7.0975438
94b.l19x2 7.08167639
95b.b20x2 6.555436
96b.b20x4 10.4767638
97b.b20x6 8.288536
98b.b20x7 5.1525659
99b.l20x2 6.46459
100b.b21x1 6.3475407
101b.b21x3 6.87875436
102b.b21x7 6.92505
103b.b22x5 5.95917657
104b.l22x5 6.955459
105b.b23x1 4.7475405
106b.b23x6 6.97833607
107b.l23x1 8.09625416
108b.b24x2 5.57254265
109b.b24x4 7.798754266
110b.l24x2 3.914556
111b.l25x3 7.562589
112b.l25x6 11.995418
113b.l27x1 11.7914719
114b.l27x2 6.585589
115b.b28x4 7.73125486
116b.b28x6 7.89333689
117b.b28x7 7.4925409
118g.h1x11 1.9475409
119g.h2x11 10.9825456
120g.ctx3 6.23509
121g.ctx14 5.5056119
1221x35 6.87875424
1231x39 8.50875407
1241x50 4.2075409
1251x54 2.5625407
1262x42 4.463508
1272x46 5.216254109
1282x50 5.4485109
1292x51 3.266507
130E1x50 5.318528
131E1x52 6.115406
1323x50 6.535509
133I2x56 5.5845285
134I2x57 6.2335287
1354x61 8.28125427
136E2 14.6051223
137E2x52 8.30625425
1385x36 3.8525425
1395x39 6.6475428
1405x461 3.58407
1415x47 6.75408
1425x54 5.076254148
1435x58 6.2745149
1446x30 4.029508
1456x43 2.445406
1466x48 7.27508
1476x52 5.555527
148E3 11.5007723
1497x32 3.07875403
1507x34 7.52425
1517x37 3.50375426
1527x38 5.796526
1537x42 7.6627
1547x49 5.1365109
1557x53 4.98756109
1568x48 3.645406
157Lig 15.5722020
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b4x4 b.l1x3 12.964112.595YesYes689
2b.b3x6 b.l1x3 24.33989.765NoYes099
3b.b3x6 b.l3x2 23.88085.89NoYes099
4b.b4x2 b.l3x2 21.58014.84YesYes089
5b.b4x2 b.b5x8 19.27063.345YesNo085
6b.b5x7 b.b5x8 18.80763.39YesNo075
7b.b3x2 b.b4x6 30.18034.555YesYes659
8b.b2x3 b.b3x2 31.00464.945YesYes665
9b.b26x2 b.b2x3 32.70475.67NoYes076
10b.b26x1 b.b26x2 33.09643.44NoNo097
11b.b26x1 b.l27x1 33.29845.56NoYes099
12b.b2x1 b.l27x1 62.24979.16YesYes189
13b.l25x5 b.l27x1 90.19687.345NoYes079
14b.l25x5 b.l27x2 90.31124.04NoYes079
15b.l25x4 b.l27x2 99.97276.65NoYes059
16I1x49 b.l25x4 99.975117.27NoNo065
171x60 I1x49 1006.685NoNo066
181x60 I1x50 93.80071.4NoNo068
192x40 I1x50 93.79751.4NoNo098
202x37 2x40 65.34628.04NoNo079
212x37 2x39 65.23333.925NoNo078
222x39 G.H5.23 65.21693.38NoNo084
233x50 G.H5.23 65.20394.875YesNo094
243x50 G.H5.25 20.49438.5YesNo097
25G.H5.20 G.H5.25 20.06133.46YesNo097
26G.H5.20 G.H5.26 18.53487.915YesYes095
27G.H5.21 G.H5.26 15.24337.445NoYes055
28G.H5.17 G.H5.21 14.79372.875NoNo055
29G.H5.17 G.h4s6.12 14.56834.725NoYes054
30G.S6.02 G.h4s6.12 13.72218.42YesYes074
31G.H5.10 G.S6.02 12.58233.335NoYes067
32G.H5.10 G.S5.03 12.35333.25NoYes068
33G.H2.10 b.b2x1 22.41486.72NoYes078
34G.H2.10 b.l7x2 22.20314.76NoYes079
35G.H2.07 b.l7x2 21.20674.555YesYes199
36b.b6x1 b.l9x6 36.53313.59NoYes098
37b.b2x1 b.b6x1 36.69173.59YesNo089
38G.H2.06 b.l9x6 19.01653.58YesYes198
39G.H2.04 G.H2.07 24.63436YesYes099
40G.H2.06 b.l17x6 19.775311.06YesYes199
41G.H2.04 G.H3.08 24.19675.465YesNo099
42G.H3.08 G.S4.04 23.98617.31NoNo099
43G.H3.09 G.S4.04 23.754211.79YesNo099
44G.H3.09 G.S5.04 19.25064.87YesYes099
45G.S5.04 G.S5.06 11.28825.535YesNo098
46G.S5.06 G.s4h3.01 10.53229.69NoYes487
47G.HG.04 G.s4h3.01 10.107713.4YesYes497
48b.l25x6 b.l27x1 22.312319.49YesYes189
49b.l17x5 b.l17x6 19.06314.415NoYes069
50b.l17x5 b.l19x2 18.80713.68NoYes069
51b.l17x3 b.l19x2 16.1626.3YesYes399
52b.b20x6 b.l17x3 13.82123.39YesYes369
53b.l23x1 b.l25x6 22.089318.465YesYes168
54b.l21x7 b.l23x1 21.64044.67NoYes056
55b.b23x6 b.l21x7 21.40755.375YesNo075
56b.b23x6 b.b24x6 16.1386.27YesNo078
57b.b21x7 b.b24x6 15.897315.92YesNo058
58b.b21x7 b.b23x2 11.01586.45YesNo056
59b.b22x5 b.b23x2 10.523212.18YesNo076
60b.b28x7 b.lhb1x11 12.17423.505YesNo094
61b.b24x3 b.b25x7 12.38545.555NoNo057
62b.b24x3 b.b26x3 11.91353.965NoNo056
63b.b23x3 b.b26x3 10.96854.155NoNo076
64b.b28x6 b.lhb1x11 11.62114.655YesNo894
65b.b28x4 b.b28x6 12.17945.8YesYes869
66b.b3x4 b.b4x6 12.97684.945NoYes699
67b.b10x1 b.l9x6 23.24126.36NoYes198
68b.b10x1 b.b11x5 24.32753.26NoNo096
69b.b11x5 b.b14x3 19.23286.76NoYes065
70b.b10x2 b.b14x3 12.74046.345NoYes065
71b.b10x2 b.b6x2 11.96273.38NoNo068
72b.b10x3 b.b6x2 11.69844.225YesNo088
73b.b27x3 b.b28x6 12.105111.52NoYes089
74b.b27x3 b.l25x3 12.28828.21NoYes089
75b.b28x4 b.l25x3 12.95027.86YesYes869
762x57 7x42 26.38175.385NoYes077
771x43 2x57 26.4866.22NoNo057
781x43 1x47 26.71229.835NoNo056
791x47 2x51 26.94863.725NoYes067
801x54 2x51 28.23042.855YesYes077
811x54 2x44 28.40132.855YesNo076
821x57 2x44 28.50334.845NoNo076
831x57 2x40 28.61224.12NoNo079
842x60 Lig 10.5693.795NoYes270
852x60 7x42 10.62977.11NoYes277
867x38 Lig 10.69786.795YesYes260
877x38 7x42 12.17119.085YesYes267
883x36 Lig 25.131511.02NoYes270
893x36 6x48 25.39864.9NoYes078
906x44 6x48 29.97148.02NoYes098
915x54 6x44 30.07667.465YesNo089
925x54 5x58 30.0583.59YesYes1489
933x50 5x58 31.35188.23YesYes099
946x52 Lig 25.68186.48YesYes270
956x48 6x52 33.97567.37YesYes087
966x48 7x45 31.36689.265YesNo089
977x45 7x49 32.29844.47NoYes099
987x49 7x53 32.26413.485YesYes1099
993x50 7x53 34.47936.685YesYes099
100E1x50 E1x52 10.92567.505YesYes086
101E2 Lig 22.598321.905YesYes230
102b.b3x4 b.l1x3 12.75069.765NoYes699
103b.b4x4 b.b4x6 12.972614.68YesYes689
104b.l25x3 b.l27x2 25.84075.04YesYes899
105b.b25x7 b.b28x6 11.894813.67NoYes879
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
1x357x324.912YesYes4312
1x357x3513.0852YesNo4512
2x563x326.480NoNo7721
2x567x4211.4250NoYes7722
2x607x384.1152NoYes7611
2x607x427.112NoYes7712
2x60Lig3.7952NoYes7010
2x63E1x503.612NoYes5812
2x63Lig4.4652NoYes5010
2x64Lig10.8550NoYes6010
2x67E23.590NoYes4321
3x25E1x505.592NoYes9822
E1x50E2x508.382YesNo8921
3x22E25.4252NoYes4321
3x25E2x506.372NoNo9921
3x294x614.420NoYes6721
3x294x654.7950NoNo6622
3x32Lig5.0752NoYes7010
3x366x484.92NoYes7812
3x36Lig11.022NoYes7010
4x61E2x5210.692YesYes7511
4x61Lig15.022YesYes7010
4x64E210.3652NoYes5321
4x65E2x526.0850NoYes6521
E2E247.742YesYes3311
E2E2x5112.262YesNo3411
E2Lig21.9052YesYes3010
E2x50Lig4.862NoYes9010
E2x51Lig12.722NoYes4010
E2E2x524.1052YesYes3511
E2x52Lig12.3452YesYes5010
5x35E25.3752NoYes4321
5x39E29.1052YesYes8321
5x366x584.4652YesNo5421
5x446x523.5850NoYes7721
5x4616x524.150YesYes7721
6x486x527.370YesYes8721
6x517x373.7450NoYes7622
6x517x384.910NoYes7621
6x52Lig6.482YesYes7010
6x55Lig13.270NoYes7010
6x576x618.3752NoNo5422
6x57E315.22NoYes5321
6x58E38.2552NoYes4311
6x58Lig14.822NoYes4010
6x61E34.662NoYes4321
E3E37.992YesYes3311
E3Lig34.382YesYes3010
7x347x374.422YesYes5612
7x347x384.0752YesYes5611
7x34Lig19.9652YesYes5010
7x387x429.0852YesYes6712
1x35Lig7.152YesYes4010
7x31Lig3.660NoYes3010
7x38Lig6.7952YesYes6010
5x36E24.52YesYes5321
5x476x526.190YesYes8721
E1x49E23.152NoYes4321
4x574x612.9950NoYes8721
1x321x352.370NoYes4421
6x62E32.030NoYes0321
6x547x341.622NoYes5521
6x547x371.622NoYes5622

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
83.33Consensuscck_onOrthosteric Ligandccka_on cckb_on
83.33Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
81.82Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
80.00Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
76.19Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
73.68Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
73.68Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
73.68Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
71.43Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
70.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
66.67Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
65.22Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
65.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
61.90Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
60.87Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
60.00Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
60.00Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
59.09Single7F8XNN90567F8X-CCKA-NN9056
58.33Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
57.69Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
57.69Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
57.69Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
57.69Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
57.69Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
57.69Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
56.52Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
56.00Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
56.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
55.00Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
54.17Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
54.17Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
54.17Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
53.85Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
53.85Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
53.57Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
53.57Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
53.57Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
52.38Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
52.38Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
50.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
50.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
50.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
50.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
50.00Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
50.00Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
48.28Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
48.28Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
48.28Consensusbombesin_onOrthosteric Ligandbb2_on
48.28Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
48.28Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
48.00Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
48.00Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
48.00Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
48.00Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
48.00Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
48.00Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
48.00Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
48.00Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
48.00Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
47.83Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
47.83Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
47.83Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
47.83Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
47.83Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
47.83Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
47.62Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.62Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
47.37Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
47.37Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
47.37Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
46.43Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
46.43Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
46.15Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
46.15Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
45.83Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
45.83Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
45.83Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
45.83Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
45.83Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
45.45Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
45.45Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
45.45Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
45.45Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
45.45Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
45.45Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
45.45Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
45.45Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
45.45Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
45.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
45.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
45.00Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
45.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
45.00Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
45.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
44.83Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
44.83Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
44.44Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
44.44Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
44.44Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
44.00Single3QAKUK-4320973QAK-A2A-UK-432097
44.00Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
44.00Single7SK5CXCL127SK5-ACKR3-CXCL12
44.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
44.00Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
44.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
44.00Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
44.00Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
43.75Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
43.48Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
43.48Single7EZCUKA7EZC-A2A-UKA
43.48Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
42.86Single4XT3Fractalkine4XT3-US28-Fractalkine
42.86Single5N2SPSB365N2S-A1-PSB36
42.86Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
42.86Single8GNEKW-63568GNE-A2A-KW-6356-Na
42.86Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
42.31Single5WF5UK-4320975WF5-A2A-UK-432097
42.31Single6PT2KGCHM076PT2-δ-KGCHM07
42.31Consensusangiotensin_onOrthosteric Ligandat1_on
42.31Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
42.31Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
42.11Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
42.11Single7F8ULintitript7F8U-CCKA-Lintitript
42.11Single8GNGIstradefylline8GNG-A2A-Istradefylline
41.67Single4UG2CGS216804UG2-A2A-CGS21680
41.67Single5WF6UK-4320975WF6-A2A-UK-432097
41.67Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
41.67Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
41.67Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
41.67Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
41.67Single7XN9L-054,5227XN9-SST2-L-054,522
41.67Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
41.67Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
41.67Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
41.67Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
41.38Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
41.38Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
41.38Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
40.91Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
40.91Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.91Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
40.91Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
40.74Single6JODAngiotensin II6JOD-AT2-Angiotensin II
40.74Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
40.74Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
40.74Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.74Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.74Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
40.74Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
40.74Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
40.74Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
40.74Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
40.74Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
40.74Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
40.74Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
40.62Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
40.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
40.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
40.00Single4XT1Fractalkine4XT1-US28-Fractalkine
40.00Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
40.00Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
40.00Single6IGLIRL16206IGL-ETB-IRL1620
40.00Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
40.00Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
40.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
40.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
40.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
40.00Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
40.00Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
40.00Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
40.00Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
40.00Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
40.00Single8WDTphotoNECA8WDT-A2A-photoNECA
40.00Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
40.00Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
40.00Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
40.00Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
40.00Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
40.00Consensushca_onOrthosteric Ligandhca2_on
40.00Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
40.00Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
39.29Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
39.29Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
39.29Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
39.29Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
39.29Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
39.29Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
39.29Single8ZRTET-18ZRT-ETB-ET-1
39.29Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
39.29Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
39.29Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
39.29Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
39.29Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
39.13Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
39.13Single6MXTSalmeterol6MXT-β2-Salmeterol
39.13Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
39.13Single6OS2TRV0266OS2-AT1-TRV026
39.13Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
39.13Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
39.13Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
39.13Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
39.13Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
39.13Single8JJLOlodaterol8JJL-β2-Olodaterol
39.13Single8JWY2-1188JWY-A2A-2-118
39.13Single8JWZAB9288JWZ-A2A-AB928-Na
39.13Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
39.13Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
39.13Consensusorexin_onOrthosteric Ligandox2_on
38.89Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
38.71Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
38.71Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
38.46Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
38.46Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
38.46Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
38.46Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
38.46Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
38.46Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
38.46Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
38.46Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
38.46Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
38.10Single3EMLZM-2413853EML-A2A-ZM-241385
38.10Single5DHHSB-6121115DHH-NOP-SB-612111
38.10Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
38.10Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
38.10Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
38.10Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
38.10Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
38.10Single6S0LZM-2413856S0L-A2A-ZM-241385
38.10Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
38.10Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
38.10Single8CU6LJ-45178CU6-A2A-LJ-4517
38.10Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
38.10Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
38.10Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
38.10Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
38.10Single8K5DGSK2560738K5D-HCA2-GSK256073
38.10Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
38.10Consensuscck_offOrthosteric Ligandccka_off
38.10Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
38.10Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
38.10Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
38.10Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
38.10Consensushca_on_gpOrthosteric Ligandhca2_on_gp
37.93Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
37.93Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
37.93Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
37.93Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
37.93Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
37.93Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
37.93Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
37.93Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
37.50Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
37.50Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
37.50Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
37.50Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
37.50Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
37.50Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
37.50Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
37.50Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.50Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.50Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
37.50Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
37.50Consensusprostanoid_offOrthosteric Ligandep_off dp_off
37.04Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
37.04Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
37.04Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
37.04Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
37.04Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
37.04Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
37.04Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
36.84Single3OE9IT1t3OE9-CXCR4-IT1t
36.84Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
36.84Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
36.84Single8K5BNiacin8K5B-HCA2-Niacin
36.36Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
36.36Single5IUAQ274563485IUA-A2A-Q27456348-Na
36.36Single5N2RPSB-365N2R-A2A-PSB-36-Na
36.36Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
36.36Single6D26Fevipiprant6D26-DP2-Fevipiprant
36.36Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
36.36Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
36.36Single6S0QZM-2413856S0Q-A2A-ZM-241385
36.36Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
36.36Single7C61Ergotamine7C61-5-HT1B-Ergotamine
36.36Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
36.36Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
36.36Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.36Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.36Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
36.36Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
36.36Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
36.36Single8QOTNanobody-E8QOT-μ-Nanobody-E
36.36Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
36.36Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
36.36Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
36.36Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
36.36Consensusadenosine_offOrthosteric Liganda1_off a2_off
36.36Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
36.36Consensusdp_offOrthosteric Liganddp2_off
36.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
36.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
36.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
36.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
36.00Single8QJ2pN1628QJ2-MC4-pN162-Gs
36.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
35.71Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
35.71Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
35.71Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
35.48Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
35.48Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
35.48Consensusbradykinin_onOrthosteric Ligandbk2_on
35.48Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
35.48Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
35.48Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
35.48Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
35.00Single3ODUIT1t3ODU-CXCR4-IT1t
35.00Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
35.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
35.00Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
35.00Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
35.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
35.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
35.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
35.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
35.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
35.00Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
35.00Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
35.00Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
35.00Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
34.78Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
34.78Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
34.78Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
34.78Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
34.78Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
34.78Single7PX4PSB-21137PX4-A2A-PSB-2113
34.78Single7TUYGSK682753A7TUY-GPR183-GSK682753A
34.78Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
34.78Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
34.78Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
34.78Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
34.78Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
34.78Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
34.78Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
34.78Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
34.78Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
34.78Consensusa2_onOrthosteric Liganda2b_on
34.78Consensusa2_on_gpOrthosteric Liganda2b_on_gp
34.78Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
34.78Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
34.78Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
34.78Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
34.78Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
34.78Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
34.62Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
34.62Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
34.62Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
34.62Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
34.62Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
34.62Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
34.62Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
34.62Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
34.62Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
34.62Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
34.48Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
34.48Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
34.48Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
34.48Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
34.48Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
34.48Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
34.48Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
34.48Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
34.48Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
34.48Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
34.38Single5GLHEndothelin-15GLH-ETB-Endothelin-1
34.38Single6IGKEndothelin-36IGK-ETB-Endothelin-3
34.38Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
34.38Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
33.33Single3REYXAC3REY-A2A-XAC
33.33Single4RWADIPP-NH24RWA-δ-DIPP-NH2
33.33Single4XEENeurotensin4XEE-NTS1-Neurotensin
33.33Single4XESNeurotensin4XES-NTS1-Neurotensin
33.33Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
33.33Single5IU7Q274563465IU7-A2A-Q27456346-Na
33.33Single5IUBQ274563445IUB-A2A-Q27456344-Na
33.33Single5JTBZM-2413855JTB-A2A-ZM-241385
33.33Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
33.33Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
33.33Single5UVIZM-2413855UVI-A2A-ZM-241385
33.33Single6FJ3PTH6FJ3-PTH1-PTH
33.33Single6MH8ZM-2413856MH8-A2A-ZM-241385
33.33Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
33.33Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
33.33Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
33.33Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
33.33Single7AROLUF58337ARO-A2A-LUF5833-Na
33.33Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
33.33Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
33.33Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
33.33Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
33.33Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
33.33Single7SK3CXCL127SK3-ACKR3-CXCL12
33.33Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
33.33Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
33.33Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
33.33Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
33.33Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7XNACYN1548067XNA-SST2-CYN154806
33.33Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
33.33Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
33.33Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
33.33Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
33.33Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8IHKAcifran8IHK-HCA3-Acifran
33.33Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
33.33Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
33.33Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
33.33Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
33.33Single8K5CAcipimox8K5C-HCA2-Acipimox
33.33Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
33.33Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
33.33Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
33.33Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
33.33Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
33.33Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
33.33Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
33.33Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
33.33Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
33.33Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
33.33Consensusa2_offOrthosteric Liganda2a_off
33.33Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
33.33Consensusalpha1_offOrthosteric Ligandalpha1a_off
33.33Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
33.33Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
33.33Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
33.33Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
33.33Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
33.33Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
33.33Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
33.33Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
33.33Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
33.33Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
33.33Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
33.33Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
33.33Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
33.33Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
33.33Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
33.33Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
33.33Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
32.35Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
32.26Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
32.26Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
32.14Single3OE0CVX153OE0-CXCR4-CVX15
32.14Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
32.14Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
32.14Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
32.14Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.14Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
32.14Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
32.14Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
32.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
32.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
32.00Single6IBLArformoterol6IBL-β1-Arformoterol
32.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
32.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
32.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
32.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
32.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
32.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
32.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
32.00Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
32.00Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
32.00Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
32.00Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
32.00Consensuschemerin_onOrthosteric Ligandcml1_on
32.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
32.00Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
32.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
31.82Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
31.82Single5IU8Q274563475IU8-A2A-Q27456347-Na
31.82Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
31.82Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
31.82Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
31.82Single5UENDU1725UEN-A1-DU172
31.82Single5UIGCmpd-15UIG-A2A-Cmpd-1
31.82Single6D27CAY104716D27-DP2-CAY10471
31.82Single6PS1Timolol6PS1-β2-Timolol
31.82Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
31.82Single7PYRPSB-21157PYR-A2A-PSB-2115
31.82Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
31.82Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
31.82Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
31.82Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
31.82Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
31.82Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
31.82Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
31.82Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
31.82Single9CHXS-Carazolol9CHX-β2-S-Carazolol
31.82Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
31.82Consensusa3_onOrthosteric Liganda3a_on
31.82Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
31.82Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
31.82Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
31.82Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
31.82Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
31.82Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
31.58Single3OE6IT1t3OE6-CXCR4-IT1t
31.58Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
31.25Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
31.25Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
31.25Single8IY6Endothelin-18IY6-ETB-Endothelin-1
31.25Consensusendothelin_onOrthosteric Ligandetb_on eta_on
31.03Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
31.03Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
31.03Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
31.03Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
31.03Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
31.03Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
31.03Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
31.03Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
31.03Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
31.03Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
31.03Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
31.03Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
31.03Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
31.03Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
31.03Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
31.03Consensusvasop-oxy_onOrthosteric Ligandv2_on
31.03Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
30.77Single3NY9ICI118-5513NY9-β2-ICI118-551
30.77Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
30.77Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
30.77Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
30.77Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
30.77Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
30.77Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
30.77Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
30.77Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
30.77Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
30.77Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
30.77Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
30.43Single5C1MBU725C1M-μ-BU72
30.43Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
30.43Single5WQCEMPA5WQC-OX2-EMPA
30.43Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
30.43Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
30.43Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
30.43Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
30.43Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
30.43Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
30.43Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
30.43Single7W41PD1762527W41-BB2-PD176252
30.43Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
30.43Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
30.43Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
30.43Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
30.43Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
30.43Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
30.43Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
30.43Single8S4DCMF-0198S4D-Apelin-CMF-019
30.43Single8TF5Oleic acid8TF5-GPR6-Oleic acid
30.43Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
30.43Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
30.43Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
30.43Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
30.43Consensusa3_on_gpOrthosteric Liganda3a_on_gp
30.43Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
30.43Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
30.43Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
30.43Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
30.43Consensusbombesin_offOrthosteric Ligandbb2_off
30.43Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
30.43Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
30.43Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
30.43Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
30.43Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
30.30Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
30.00Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
30.00Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
30.00Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
30.00Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
30.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
30.00Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
30.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
30.00Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
30.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
30.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
30.00Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
30.00Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
30.00Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
30.00Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
30.00Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
30.00Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
30.00Consensusgq_nucleotideOrthosteric Ligandgq_p2y
30.00Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
29.63Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
29.63Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
29.63Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
29.63Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
29.63Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
29.63Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
29.63Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
29.63Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
29.63Single8WKYPG-9348WKY-MC4-PG-934
29.63Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
29.63Single8XWNCXCL88XWN-CXCR2-CXCL8
29.63Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
29.63Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Consensussomatostatin_offOrthosteric Ligandsst2_off
29.41Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
29.17Single2YDVNECA2YDV-A2A-NECA
29.17Single3P0GBI1671073P0G-β2-BI167107
29.17Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
29.17Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
29.17Single4UHRCGS216804UHR-A2A-CGS21680
29.17Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
29.17Single5G53NECA5G53-A2A-NECA-Gs
29.17Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
29.17Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
29.17Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
29.17Single6OS1TRV0266OS1-AT1-TRV026
29.17Single6TQ7SB-3348676TQ7-OX1-SB-334867
29.17Single6WGTLSD6WGT-5-HT2A-LSD
29.17Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
29.17Single7B6WCyclazosin7B6W-α1b-Cyclazosin
29.17Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
29.17Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
29.17Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
29.17Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
29.17Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
29.17Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
29.17Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
29.17Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
29.17Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.17Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
29.17Single8E0GBU728E0G-μ-BU72
29.17Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
29.17Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.17Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
29.17Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
29.17Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
29.17Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
29.17Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
29.17Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
29.17Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
29.17Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
29.17Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
29.17Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
29.17Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
29.17Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
29.17Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
29.17Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
29.17Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
29.17Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
29.17Consensusneurotensin_onOrthosteric Ligandnts1_on
29.17Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
29.17Consensusrelaxin_onOrthosteric Ligandrxfp4_on
29.17Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
29.03Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
29.03Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
29.03Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
28.57Single3PWHZM-2413853PWH-A2A-ZM-241385
28.57Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
28.57Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
28.57Single5ZKQABT-4915ZKQ-PAF-ABT-491
28.57Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
28.57Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
28.57Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
28.57Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
28.57Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
28.57Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
28.57Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
28.57Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
28.57Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
28.57Single7XRRLemborexant7XRR-OX2-Lemborexant
28.57Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
28.57Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
28.57Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
28.57Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
28.57Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
28.57Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
28.57Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
28.57Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
28.57Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
28.57Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
28.57Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
28.57Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
28.57Consensusalpha2_offOrthosteric Ligandalpha2c_off
28.57Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
28.57Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
28.57Consensusorexin_offOrthosteric Ligandox2_off ox1_off
28.57Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
28.57Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
28.57Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
28.57Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
28.57Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
28.12Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
28.12Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.12Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
28.12Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
28.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
28.00Single4AMIBucindolol4AMI-β1-Bucindolol
28.00Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
28.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
28.00Single6A93Risperidone6A93-5-HT2A-Risperidone
28.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
28.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
28.00Single7DFPSpiperone7DFP-D2-Spiperone
28.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
28.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
28.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
28.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
28.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
28.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
28.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
28.00Single7YITNalfurafine7YIT-κ-Nalfurafine
28.00Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
28.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
28.00Single8JJ8Formoterol8JJ8-β2-Formoterol
28.00Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
28.00Single8XYIVUF106618XYI-CXCR3-VUF10661
28.00Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
28.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
28.00Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
28.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
28.00Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
28.00Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
28.00Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
28.00Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
28.00Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
28.00Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
28.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
28.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
28.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
28.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
28.00Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
28.00Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
28.00Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
28.00Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
28.00Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
28.00Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
28.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
27.78Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
27.59Single6W25SHU91196W25-MC4-SHU9119-Ca
27.59Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
27.59Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
27.59Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
27.59Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
27.59Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
27.59Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
27.27Single2YDOAdenosine2YDO-A2A-Adenosine
27.27Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
27.27Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
27.27Single4ZJCSB-6740424ZJC-OX1-SB-674042
27.27Single6AQFZM-2413856AQF-A2A-ZM-241385
27.27Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
27.27Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
27.27Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
27.27Single6PS0S-Carazolol6PS0-β2-S-Carazolol
27.27Single6PS4ICI118-5516PS4-β2-ICI118-551
27.27Single6PS5S-Propranolol6PS5-β2-S-Propranolol
27.27Single6TPGEMPA6TPG-OX2-EMPA
27.27Single6V9SGTPL114036V9S-OX1-GTPL11403
27.27Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
27.27Single6ZG9GSK10347026ZG9-M1-GSK1034702
27.27Single7T32ZM-2413857T32-A2A-ZM-241385
27.27Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
27.27Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
27.27Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
27.27Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
27.27Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
27.27Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
27.27Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
27.27Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
27.27Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
27.27Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
27.27Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
27.27Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
27.27Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
27.27Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
27.27Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
27.27Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
27.27Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
27.27Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
27.27Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
27.27Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
27.27Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
27.27Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
27.27Consensusgrh_offOrthosteric Ligandgnrh1_off
27.27Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
26.92Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
26.92Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
26.92Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
26.92Single6H7LDobutamine6H7L-β1-Dobutamine
26.92Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
26.92Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
26.92Single7UM4AS26747237UM4-5-HT5A-AS2674723
26.92Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
26.92Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.92Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
26.92Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
26.92Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
26.92Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
26.92Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
26.92Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
26.92Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.92Single8XVUCXCL28XVU-CXCR2-CXCL2
26.92Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
26.92Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
26.92Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
26.92Consensusendothelin_offOrthosteric Ligandetb_off
26.92Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
26.92Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
26.92Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
26.67Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
26.67Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
26.67Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
26.67Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
26.67Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
26.67Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
26.32Single8A2OTheophylline8A2O-A2A-Theophylline-Na
26.09Single2Y02Carmoterol2Y02-β1-Carmoterol
26.09Single3NY8ICI118-5513NY8-β2-ICI118-551
26.09Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
26.09Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
26.09Single4GBRS-Carazolol4GBR-β2-S-Carazolol
26.09Single4YAYZD-71554YAY-AT1-ZD-7155
26.09Single5DHGC-355DHG-NOP-C-35
26.09Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
26.09Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
26.09Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
26.09Single6TOTLemborexant6TOT-OX1-Lemborexant
26.09Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
26.09Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
26.09Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
26.09Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
26.09Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
26.09Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
26.09Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
26.09Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
26.09Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
26.09Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
26.09Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
26.09Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
26.09Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
26.09Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
26.09Single7UL4Alvimopan7UL4-μ-Alvimopan
26.09Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
26.09Single7V3ZCP559407V3Z-CB1-CP55940
26.09Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
26.09Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
26.09Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
26.09Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
26.09Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
26.09Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
26.09Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
26.09Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
26.09Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
26.09Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
26.09Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
26.09Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
26.09Single8JJOAlprenolol8JJO-β2-Alprenolol
26.09Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
26.09Single8RLNLUF58348RLN-A2A-LUF5834
26.09Single8T1WCVN4248T1W-GPR6-CVN424
26.09Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
26.09Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
26.09Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
26.09Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
26.09Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
26.09Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
26.09Consensus5ht5_onOrthosteric Ligand5ht5a_on
26.09Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
26.09Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
26.09Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
26.09Consensusdopamine_offOrthosteric Ligandd2_off d3_off
26.09Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
26.09Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
26.09Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
25.93Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
25.93Single5ZTYAM102575ZTY-CB2-AM10257
25.93Single6PT3DPI-2876PT3-δ-DPI-287
25.93Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
25.93Single8X5YAstemizole8X5Y-H1-Astemizole
25.93Single8XQJJN2418XQJ-Apelin-JN241
25.93Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
25.93Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
25.93Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
25.93Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
25.93Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
25.93Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
25.93Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
25.81Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
25.81Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
25.71Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
25.71Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
25.00Single2RH1S-Carazolol2RH1-β2-S-Carazolol
25.00Single2YCWS-Carazolol2YCW-β1-S-Carazolol
25.00Single4XNWMRS25004XNW-P2Y1-MRS2500
25.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
25.00Single5D6LS-Carazolol5D6L-β2-S-Carazolol
25.00Single5JQHS-Carazolol5JQH-β2-S-Carazolol
25.00Single5TVNLSD5TVN-5-HT2B-LSD
25.00Single5WIUNemonapride5WIU-D4-Nemonapride
25.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
25.00Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
25.00Single6E67BI1671076E67-β2-BI167107-Gs (fused)
25.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
25.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
25.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
25.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
25.00Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
25.00Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
25.00Single6PS6Timolol6PS6-β2-Timolol
25.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
25.00Single6TP6Filorexant6TP6-OX1-Filorexant
25.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
25.00Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
25.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
25.00Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
25.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
25.00Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
25.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
25.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
25.00Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
25.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
25.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
25.00Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
25.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
25.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
25.00Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
25.00Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
25.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
25.00Single8JXSPF-61428JXS-D1-PF-6142
25.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
25.00Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
25.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
25.00Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
25.00Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
25.00Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
25.00Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
25.00Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
25.00Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
25.00Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
25.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
25.00Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
25.00Consensusamine_offonOrthosteric Ligandamine_off amine_on
25.00Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
25.00Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
25.00Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
25.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
25.00Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
25.00Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
25.00Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
25.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
25.00Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
25.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
25.00Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
25.00Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
25.00Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
25.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
25.00Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
25.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Consensustrace-amine_onOrthosteric Ligandta1_on
24.32Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
24.32Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
24.24Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
24.24Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
24.24Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
24.24Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
24.24Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
24.14Single6HLOAprepitant6HLO-NK1-Aprepitant
24.14Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
24.14Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
24.14Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
24.14Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
24.14Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
24.14Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
24.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
24.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
24.00Single4DJHJDTic4DJH-κ-JDTic
24.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
24.00Single5D5AS-Carazolol5D5A-β2-S-Carazolol
24.00Single5D5BS-Carazolol5D5B-β2-S-Carazolol
24.00Single5V56TC1145V56-SMO-TC114
24.00Single5XR8AM8415XR8-CB1-AM841
24.00Single5XRAAM115425XRA-CB1-AM11542
24.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
24.00Single6J20Aprepitant6J20-NK1-Aprepitant
24.00Single6J21Aprepitant6J21-NK1-Aprepitant
24.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
24.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
24.00Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
24.00Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
24.00Single7FEECP559407FEE-CB1-CP55940-ZCZ011
24.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
24.00Single7R0CAVP7R0C-V2-AVP-Arrestin2
24.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
24.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
24.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
24.00Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
24.00Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
24.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
24.00Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
24.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
24.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
24.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
24.00Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
24.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
24.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
24.00Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
24.00Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
24.00Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
24.00Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
24.00Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
24.00Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
24.00Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
24.00Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
24.00Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
24.00Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
24.00Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
24.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
24.00Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.00Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
23.81Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
23.81Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
23.81Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
23.81Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
23.81Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
23.81Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
23.81Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
23.81Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
23.81Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
23.81Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
23.81Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
23.81Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
23.81Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
23.53Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
23.53Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
23.33Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
23.33Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
23.33Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
23.33Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
23.33Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
23.08Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
23.08Single3D4STimolol3D4S-β2-Timolol
23.08Single4LDEBI1671074LDE-β2-BI167107
23.08Single4N4WSANT-14N4W-SMO-SANT-1
23.08Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
23.08Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
23.08Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
23.08Single6KQICP559406KQI-CB1-CP55940-Org27569
23.08Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
23.08Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
23.08Single7K15MKD0467K15-BLT1-MKD046-Na
23.08Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
23.08Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
23.08Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
23.08Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
23.08Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.08Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
23.08Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
23.08Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
23.08Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
23.08Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
23.08Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Single8XQJJN2418XQJ-Apelin-JN241
23.08Single8XWACXCL18XWA-CXCR2-CXCL1
23.08Single8XWMCXCL68XWM-CXCR2-CXCL6
23.08Single8XWSCXCL58XWS-CXCR2-CXCL5
23.08Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
23.08Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
23.08Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
23.08Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
23.08Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
23.08Consensuslpa_offOrthosteric Ligandlpa1_off
23.08Consensuslpl_offOrthosteric Ligands1p_off lpa_off
23.08Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
23.08Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.08Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.73Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
22.73Single4BWBNeurotensin4BWB-NTS1-Neurotensin
22.73Single4S0VSuvorexant4S0V-OX2-Suvorexant
22.73Single5WS3EMPA5WS3-OX2-EMPA
22.73Single6AKXA4R6AKX-CCR5-A4R
22.73Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
22.73Single6ME2Ramelteon6ME2-MT1-Ramelteon
22.73Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
22.73Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
22.73Single6TODEMPA6TOD-OX1-EMPA-Na
22.73Single6TPJSuvorexant6TPJ-OX2-Suvorexant
22.73Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
22.73Single7BR3Elagolix7BR3-GnRH1-Elagolix
22.73Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
22.73Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
22.73Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
22.73Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
22.73Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
22.73Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
22.73Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
22.73Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
22.73Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
22.73Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
22.73Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
22.73Single8IWESpermidine8IWE-TA9-Spermidine
22.73Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
22.73Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
22.73Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
22.73Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
22.73Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
22.73Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
22.73Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
22.73Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
22.73Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
22.73Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
22.73Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
22.73Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
22.73Consensusangiotensin_offOrthosteric Ligandat1_off
22.73Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
22.73Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
22.73Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
22.73Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
22.73Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
22.73Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
22.73Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
22.58Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
22.58Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
22.58Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
22.58Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
22.58Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
22.22Single5X93K-87945X93-ETB-K-8794
22.22Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
22.22Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
22.22Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
22.22Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
22.22Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
22.22Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
22.22Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
22.22Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
22.22Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
22.22Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
22.22Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
22.22Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
22.22Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
22.22Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
22.22Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
22.22Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8XWFCXCL38XWF-CXCR2-CXCL3
22.22Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
22.22Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
21.88Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
21.88Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
21.88Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
21.74Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
21.74Single4MBSMaraviroc4MBS-CCR5-Maraviroc
21.74Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
21.74Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
21.74Single6IQLL7458706IQL-D4-L745870
21.74Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
21.74Single6KUXRS-799486KUX-α2a-RS-79948
21.74Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
21.74Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
21.74Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
21.74Single6TP3Nemorexant6TP3-OX1-Nemorexant
21.74Single6TPNHTL66416TPN-OX2-HTL6641
21.74Single6VI4JDTic6VI4-κ-JDTic
21.74Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
21.74Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
21.74Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
21.74Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
21.74Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
21.74Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
21.74Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.74Single7UL3Famotidine7UL3-H2-Famotidine
21.74Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
21.74Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
21.74Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
21.74Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
21.74Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
21.74Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
21.74Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
21.74Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
21.74Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.74Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
21.74Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
21.74Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
21.74Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
21.74Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
21.74Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
21.74Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
21.74Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
21.74Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
21.74Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
21.74Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
21.74Consensusalpha1_onOrthosteric Ligandalpha1a_on
21.74Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
21.74Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
21.74Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
21.74Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
21.74Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
21.74Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
21.74Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
21.62Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
21.62Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
21.43Single5EE7MK08935EE7-Glucagon-MK0893
21.43Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
21.43Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
21.43Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single7SK9CCX6627SK9-ACKR3-CCX662
21.43Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
21.43Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
21.21Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
21.21Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
21.21Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
21.21Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
21.21Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
21.05Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
21.05Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
21.05Single8PWNTheophylline8PWN-A2A-Theophylline
21.05Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.83Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
20.83Single2Y04Salbutamol2Y04-β1-Salbutamol
20.83Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
20.83Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
20.83Single4EJ4Naltrindole4EJ4-δ-Naltrindole
20.83Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
20.83Single4QIMANTA XV4QIM-SMO-ANTA XV
20.83Single4QKX35V4QKX-β2-35V
20.83Single6DRXLisuride6DRX-5-HT2B-Lisuride
20.83Single6H7MSalbutamol6H7M-β1-Salbutamol
20.83Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
20.83Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
20.83Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
20.83Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
20.83Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
20.83Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
20.83Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
20.83Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
20.83Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
20.83Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
20.83Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
20.83Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
20.83Single7WC7Lisuride7WC7-5-HT2A-Lisuride
20.83Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
20.83Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
20.83Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
20.83Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
20.83Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
20.83Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
20.83Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
20.83Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
20.83Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
20.83Single8JXRLSD8JXR-D1-LSD
20.83Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
20.83Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
20.83Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
20.83Single8X63Mepyramine8X63-H1-Mepyramine
20.83Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
20.83Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
20.83Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
20.83Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
20.83Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
20.83Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
20.83Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
20.83Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
20.83Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
20.83Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
20.83Consensusalpha2_onOrthosteric Ligandalpha2b_on
20.83Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
20.83Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
20.83Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
20.83Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
20.83Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
20.83Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
20.83Consensusblt_onOrthosteric Ligandblt1_on
20.83Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
20.83Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
20.83Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
20.83Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
20.83Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
20.83Consensushistamine_offOrthosteric Ligandh1_off
20.83Consensusleukotriene_onOrthosteric Ligandblt_on
20.83Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
20.83Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
20.69Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
20.69Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
20.69Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
20.69Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
20.69Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
20.69Single8KIGSHU91198KIG-MC3-SHU9119-Ca
20.69Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
20.69Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.69Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
20.69Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
20.69Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.69Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.69Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
20.59Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
20.59Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
20.59Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
20.59Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
20.59Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
20.59Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
20.00Single2Y00Dobutamine2Y00-β1-Dobutamine
20.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
20.00Single3OE8IT1t3OE8-CXCR4-IT1t
20.00Single3RFMCaffeine3RFM-A2A-Caffeine
20.00Single4JKVTaladegib4JKV-SMO-Taladegib
20.00Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
20.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
20.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
20.00Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
20.00Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
20.00Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
20.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
20.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
20.00Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
20.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
20.00Single7C4SS1P7C4S-S1P3-S1P
20.00Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
20.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
20.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
20.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
20.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
20.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
20.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
20.00Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
20.00Single7WC6LSD7WC6-5-HT2A-LSD
20.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
20.00Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
20.00Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
20.00Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8IEBA1LYA8IEB-GPR156-A1LYA
20.00Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
20.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
20.00Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
20.00Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
20.00Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
20.00Single8ZMFA1L108ZMF-5-HT2C-A1L10
20.00Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
20.00Single9CHUNoradrenaline9CHU-β2-Noradrenaline
20.00Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
20.00Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
20.00Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
20.00Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
20.00Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
20.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
20.00Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
20.00Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
20.00Consensusblt_offOrthosteric Ligandblt1_off
20.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
20.00Consensusep_offOrthosteric Ligandep4_off
20.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
20.00Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
20.00Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
20.00Consensusp2y_offOrthosteric Ligandp2y1_off
19.51Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
19.44Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
19.35Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.35Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
19.23Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
19.23Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
19.23Single5V57TC1145V57-SMO-TC114
19.23Single6E59L-7607356E59-NK1-L-760735
19.23Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
19.23Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
19.23Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
19.23Single7F1TMIP-1a7F1T-CCR5-MIP-1a
19.23Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
19.23Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
19.23Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
19.23Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
19.23Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
19.23Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
19.23Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
19.23Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
19.23Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
19.23Single8XVLZibotentan8XVL-ETA-Zibotentan
19.23Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
19.23Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
19.23Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
19.23Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
19.23Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
19.23Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
19.23Consensustachykinin_offOrthosteric Ligandnk1_off
19.05Single3UZAGTPL92363UZA-A2A-GTPL9236
19.05Single6ME5Agomelatine6ME5-MT1-Agomelatine
19.05Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
19.05Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
19.05Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
19.05Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
19.05Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
19.05Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
19.05Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
19.05Consensus5ht2_onOrthosteric Ligand5ht2b_on
19.05Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.92Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
18.75Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
18.75Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
18.75Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
18.75Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
18.75Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
18.60Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
18.52Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
18.52Single6CM4Risperidone6CM4-D2-Risperidone
18.52Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
18.52Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
18.52Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
18.52Single6ZG4HTL00099366ZG4-M1-HTL0009936
18.52Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
18.52Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
18.52Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
18.52Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
18.52Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
18.52Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
18.52Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
18.52Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
18.52Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
18.52Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
18.52Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
18.52Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
18.42Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
18.42Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
18.18Single3PBLEticlopride3PBL-D3-Eticlopride
18.18Single5L7IVismodegib5L7I-SMO-Vismodegib
18.18Single6HLLCP999946HLL-NK1-CP99994
18.18Single6TP4ACT-4622066TP4-OX1-ACT-462206
18.18Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
18.18Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
18.18Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
18.18Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
18.18Single7SRQLSD7SRQ-5-HT2B-LSD
18.18Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
18.18Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
18.18Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
18.18Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
18.18Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
18.18Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
18.18Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
18.18Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
18.18Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
18.18Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Single9B9Y7DY9B9Y-CB1-7DY
18.18Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
18.18Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
18.18Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
17.95Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
17.86Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
17.86Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
17.86Single6K1QIRL25006K1Q-ETB-IRL2500
17.86Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
17.86Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
17.86Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
17.86Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
17.86Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
17.86Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
17.86Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
17.86Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
17.86Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
17.86Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
17.65Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
17.65Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
17.50Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
17.39Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
17.39Single6AKYMaraviroc6AKY-CCR5-Maraviroc
17.39Single6B73MP11046B73-κ-MP1104
17.39Single6DS0Ly2660976DS0-5-HT2B-Ly266097
17.39Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
17.39Single6ME9Ramelteon6ME9-MT2-Ramelteon
17.39Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
17.39Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
17.39Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
17.39Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
17.39Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
17.39Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
17.39Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
17.39Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
17.39Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
17.39Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
17.39Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
17.39Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
17.39Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
17.39Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
17.39Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
17.39Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
17.39Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
17.39Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
17.39Single8Y0HVUF114188Y0H-CXCR3-VUF11418
17.39Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
17.39Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
17.39Single9BA0A1AKN9BA0-CB1-A1AKN
17.39Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
17.39Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
17.39Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
17.39Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
17.39Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
17.39Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
17.39Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
17.39Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
17.24Single6KNMJN241-96KNM-Apelin-JN241-9
17.24Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
17.24Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
17.24Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
17.24Consensuskisspeptin_onOrthosteric Ligandkiss1_on
17.14Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
17.14Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
17.14Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
17.14Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
17.14Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
16.67Single3RZECidoxepin3RZE-H1-Cidoxepin
16.67Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
16.67Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
16.67Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
16.67Single6A94Zotepine6A94-5-HT2A-Zotepine
16.67Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
16.67Single6TPKRetosiban6TPK-OT-Retosiban
16.67Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
16.67Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
16.67Single6ZINSR486926ZIN-NTS1-SR48692
16.67Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
16.67Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
16.67Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
16.67Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
16.67Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
16.67Single7QA8Peptide7QA8-STE2-Peptide
16.67Single7QA8Peptide7QA8-STE2-Peptide
16.67Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
16.67Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
16.67Single7VODCariprazine7VOD-5-HT2A-Cariprazine
16.67Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
16.67Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
16.67Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8IEBA1LYA8IEB-GPR156-A1LYA
16.67Single8IEIA1LYA8IEI-GPR156-A1LYA
16.67Single8IEPA1LYA8IEP-GPR156-A1LYA
16.67Single8IEPA1LYA8IEP-GPR156-A1LYA
16.67Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
16.67Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
16.67Single8K2WAMG4878K2W-CXCR3-AMG487
16.67Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
16.67Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
16.67Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
16.67Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
16.67Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
16.67Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
16.67Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
16.67Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
16.67Single9BJKNaloxone9BJK-μ-Naloxone-NAM
16.67Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
16.67Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
16.67Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
16.67Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
16.67Consensusvasop-oxy_offOrthosteric Ligandot_off
16.22Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
16.22Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
16.13Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
16.13Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
16.13Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.00Single2Y01Dobutamine2Y01-β1-Dobutamine
16.00Single4DAJTiotropium4DAJ-M3-Tiotropium
16.00Single4MQSIperoxo4MQS-M2-Iperoxo
16.00Single4U14Tiotropium4U14-M3-Tiotropium
16.00Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
16.00Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
16.00Single5T04Neurotensin5T04-NTS1-Neurotensin
16.00Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
16.00Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
16.00Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
16.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
16.00Single6GPSMK08126GPS-CCR2-MK0812
16.00Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
16.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single7BU7BI1671077BU7-β1-BI167107
16.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
16.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
16.00Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
16.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
16.00Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
16.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
16.00Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
16.00Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
16.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
16.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
16.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
16.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
16.00Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
16.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
16.00Single8X64Desloratadine8X64-H1-Desloratadine
16.00Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
16.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
16.00Single9B9ZA1AKO9B9Z-CB1-A1AKO
16.00Single9IYAONO-97105319IYA-GPR55-ONO-9710531
16.00Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
16.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
15.79Single5MZPCaffeine5MZP-A2A-Caffeine-Na
15.79Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
15.62Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
15.62Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.62Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.38Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
15.38Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
15.38Single5XPRBosentan5XPR-ETB-Bosentan
15.38Single6GPXMK08126GPX-CCR2-MK0812
15.38Single6HLPNetupitant6HLP-NK1-Netupitant
15.38Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
15.38Single6Z4SSR486926Z4S-NTS1-SR48692
15.38Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
15.38Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
15.38Single7SINNPS-21437SIN-CaS-NPS-2143
15.38Single7SINNPS-21437SIN-CaS-NPS-2143
15.38Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
15.38Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
15.38Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
15.38Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
15.38Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
15.38Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
15.38Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
15.38Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
15.38Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
15.38Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
15.38Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
15.38Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
15.38Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
15.15Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
15.15Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
15.00Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
15.00Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
15.00Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
15.00Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
14.81Single4U15Tiotropium4U15-M3-Tiotropium
14.81Single5TZRMK86665TZR-FFA1-MK8666
14.81Single5V54Methiothepin5V54-5-HT1B-Methiothepin
14.81Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
14.81Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
14.81Single6OL9Tiotropium6OL9-M5-Tiotropium
14.81Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
14.81Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
14.81Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
14.81Single8EA0Iperoxo8EA0-M3-Iperoxo
14.81Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
14.81Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
14.81Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
14.81Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
14.81Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
14.81Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
14.81Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
14.81Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
14.81Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
14.81Single9BJKNAM9BJK-μ-Naloxone-NAM
14.81Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
14.81Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
14.81Consensus5ht1_offOrthosteric Ligand5ht1b_off
14.81Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
14.81Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
14.81Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
14.81Consensuslpa_onOrthosteric Ligandlpa1_on
14.81Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
14.81Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
14.81Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
14.81Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
14.81Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
14.71Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
14.29Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
14.29Single4PY02MeSATP4PY0-P2Y12-2MeSATP
14.29Single5CXVTiotropium5CXV-M1-Tiotropium
14.29Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
14.29Single5X33BIIL2605X33-BLT1-BIIL260
14.29Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
14.29Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
14.29Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
14.29Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
14.29Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
14.29Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
14.29Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
14.29Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
14.29Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
14.29Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
14.29Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
14.29Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
14.29Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
14.29Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.79Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
13.79Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single8XVJMacitentan8XVJ-ETA-Macitentan
13.79Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
13.79Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
13.79Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
13.79Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
13.64Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
13.64Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
13.64Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
13.64Single7WC5Psilocin7WC5-5-HT2A-Psilocin
13.64Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
13.64Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
13.64Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
13.64Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
13.64Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
13.64Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
13.64Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
13.64Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
13.64Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
13.51Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
13.51Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
13.33Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
13.33Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
13.33Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
13.33Single8IEIA1LYA8IEI-GPR156-A1LYA
13.33Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
13.33Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
13.33Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
13.33Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single4O9RCyclopamine4O9R-SMO-Cyclopamine
13.04Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
13.04Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
13.04Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
13.04Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
13.04Single7UL2SR486927UL2-NTS1-SR48692-Na
13.04Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
13.04Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
13.04Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
13.04Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
13.04Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
13.04Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.04Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
13.04Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
13.04Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
13.04Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
13.04Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
13.04Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
13.04Consensusneurotensin_offOrthosteric Ligandnts1_off
13.04Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
12.90Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
12.90Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
12.90Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
12.82Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
12.50Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
12.50Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
12.50Single4QINSAG1.54QIN-SMO-SAG1.5
12.50Single5U09Taranabant5U09-CB1-Taranabant
12.50Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
12.50Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
12.50Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
12.50Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.50Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.50Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
12.50Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
12.50Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
12.50Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
12.50Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
12.50Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
12.50Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
12.50Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
12.50Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
12.50Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
12.50Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
12.50Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
12.50Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
12.20Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
12.20Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
12.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
12.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
12.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
12.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
12.00Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
12.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
12.00Single7VV6C48/807VV6-MRGPRX2-C48/80
12.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
12.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
12.00Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
12.00Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.00Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
12.00Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
12.00Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
12.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
12.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
12.00Consensusopsins_offOrthosteric Ligandrhodopsin_off
12.00Consensussensory_offOrthosteric Ligandopsins_off
11.76Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
11.76Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
11.54Single5DSGTiotropium5DSG-M4-Tiotropium
11.54Single5TGZAM65385TGZ-CB1-AM6538
11.54Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
11.54Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
11.54Single6IIVDaltroban6IIV-TP-Daltroban
11.54Single7F83PF-051904577F83-Ghrelin-PF-05190457
11.54Single7YXAONO-54306087YXA-S1P5-ONO-5430608
11.54Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.54Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
11.54Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
11.54Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
11.54Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
11.54Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
11.54Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
11.54Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
11.43Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
11.11Single4NTJAZD12834NTJ-P2Y12-AZD1283
11.11Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
11.11Single5CGCHTL142425CGC-mGlu5-HTL14242
11.11Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
11.11Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
11.11Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
11.11Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
11.11Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
11.11Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
11.11Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
11.11Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
11.11Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
11.11Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
11.11Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
11.11Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
11.11Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
11.11Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
10.81Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
10.71Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
10.71Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
10.71Single7P2L4YI7P2L-mGlu5-4YI
10.71Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
10.71Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
10.71Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
10.71Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
10.71Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
10.71Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
10.71Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
10.71Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
10.53Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
10.53Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
10.34Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
10.34Single6IIURamatroban6IIU-TP-Ramatroban
10.34Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
10.34Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
10.34Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
10.00Single5CGDHTL142425CGD-mGlu5-HTL14242
10.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
10.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
10.00Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
9.52Single7WC4Serotonin7WC4-5-HT2A-Serotonin
9.52Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
9.09Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
9.09Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
9.09Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
9.09Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
9.09Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
9.09Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
9.09Consensussensory_onOrthosteric Ligandopsins_on
8.70Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
8.70Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
8.70Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
8.70Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
8.70Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
8.70Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
8.70Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
8.70Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.70Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
8.70Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
8.70Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.70Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
8.70Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
8.70Single8JPSCCL78JPS-ACKR1-CCL7
8.70Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
8.70Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
8.70Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
8.70Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
8.70Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
8.70Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
8.70Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.70Consensusgi_sensoryOrthosteric Ligandgi_opsins
8.70Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.70Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.70Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
8.70Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
8.70Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
8.33Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
8.33Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
8.33Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
8.33Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
8.33Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
8.33Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
8.33Single6LI0C176LI0-GPR52-C17
8.33Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
8.33Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
8.33Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
8.33Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
8.33Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
8.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
8.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
8.00Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
8.00Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
8.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
8.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
8.00Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
8.00Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
8.00Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
8.00Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
7.69Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
7.69Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
7.69Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.69Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
7.69Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
7.41Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
7.41Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
7.41Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
7.14Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
7.14Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
7.14Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
6.90Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
6.90Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
6.90Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
6.45Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
6.25Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
6.06Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
5.00Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.76Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
4.55Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
4.55Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
4.55Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
4.55Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
4.55Single9GE2Cholesterol9GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
4.35Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
4.35Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
4.35Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
4.17Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
4.17Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
4.17Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.17Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
4.17Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
4.17Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
4.00Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
4.00Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
4.00Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
4.00Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.00Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
4.00Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.00Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
4.00Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
3.85Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
3.85Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
3.85Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.85Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
3.85Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
3.85Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
3.85Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
3.85Single8G94CD698G94-S1P1-CD69-Gi1/β1/γ2
3.85Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
3.70Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
3.70Single6FFIMMPEP6FFI-mGlu5-MMPEP
3.70Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
3.70Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
3.70Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
3.57Single6FFHFenobam6FFH-mGlu5-Fenobam
3.45Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.45Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.45Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.33Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.33Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
3.23Single7SHEPI; PE7SHE-GPR158-PI; PE
3.12Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.86Single7SHEPI; PE7SHE-GPR158-PI; PE
2.86Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

Consensus Members
Id Members
7EZH 7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
7F8V 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
Net Summary
Imin 3.36
Number of Linked Nodes 859
Number of Links 1016
Number of Hubs 157
Number of Links mediated by Hubs 619
Number of Communities 28
Number of Nodes involved in Communities 210
Number of Links involved in Communities 293
Path Summary
Number Of Nodes in MetaPath 106
Number Of Links MetaPath 105
Number of Shortest Paths 921380
Length Of Smallest Path 3
Average Path Length 25.1599
Length of Longest Path 54
Minimum Path Strength 0.6975
Average Path Strength 6.38288
Maximum Path Strength 24.79
Minimum Path Correlation 0.7
Average Path Correlation 0.970807
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.22222
Average % Of Corr. Nodes 43.8703
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.2628
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gi_peptidegi_cck
gi_apelin
gi_compl-pept
gi_endothelin
gi_formylpeptide
gi_galanin
gi_ghrelin
gi_npy
gi_neurotensin
gi_opioid
gi_orexin
gi_relaxin
gi_somatostatin



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download gi_cck.zip



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