Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:G28 S:S:S27 3.71 0 No No 3 3 2 2
S:S:I31 S:S:S27 4.64 1 Yes No 6 3 1 2
S:S:G28 S:S:T89 1.82 0 No Yes 3 5 2 1
S:S:I31 S:S:L30 4.28 1 Yes No 6 5 1 2
S:S:I31 S:S:P32 3.39 1 Yes No 6 5 1 2
S:S:I31 S:S:Y35 8.46 1 Yes Yes 6 7 1 1
S:S:I31 S:S:P292 3.39 1 Yes Yes 6 4 1 1
S:S:C296 S:S:I31 4.91 1 No Yes 5 6 2 1
S:S:I31 W:W:V29 3.07 1 Yes Yes 6 0 1 0
S:S:P32 S:S:T89 5.25 0 No Yes 5 5 2 1
S:S:L82 S:S:Y35 2.34 1 Yes Yes 7 7 2 1
S:S:C296 S:S:Y35 6.72 1 No Yes 5 7 2 1
S:S:Y35 W:W:V29 8.83 1 Yes Yes 7 0 1 0
S:S:V38 S:S:Y299 8.83 0 No Yes 7 7 2 1
S:S:F78 S:S:I109 11.3 1 Yes Yes 6 6 2 1
S:S:F78 S:S:Y299 13.41 1 Yes Yes 6 7 2 1
S:S:T81 S:S:W85 2.43 1 Yes Yes 7 6 2 1
S:S:S105 S:S:T81 6.4 1 No Yes 5 7 2 2
S:S:I109 S:S:T81 3.04 1 Yes Yes 6 7 1 2
S:S:L82 S:S:Y299 10.55 1 Yes Yes 7 7 2 1
S:S:C102 S:S:W85 2.61 0 No Yes 9 6 2 1
S:S:S105 S:S:W85 4.94 1 No Yes 5 6 2 1
S:S:Q180 S:S:W85 3.29 1 Yes Yes 2 6 1 1
S:S:W85 W:W:F31 16.04 1 Yes Yes 6 0 1 0
S:S:T89 S:S:Y88 2.5 1 Yes Yes 5 5 1 2
S:S:Y88 S:S:Y93 15.89 1 Yes Yes 5 4 2 1
S:S:W95 S:S:Y88 3.86 1 Yes Yes 8 5 2 2
S:S:Q180 S:S:Y88 19.16 1 Yes Yes 2 5 1 2
S:S:T89 S:S:Y93 6.24 1 Yes Yes 5 4 1 1
S:S:T89 W:W:V29 3.17 1 Yes Yes 5 0 1 0
S:S:Y93 W:W:R28 12.35 1 Yes No 4 0 1 0
S:S:C102 S:S:W95 9.14 0 No Yes 9 8 2 2
S:S:Q180 S:S:W95 6.57 1 Yes Yes 2 8 1 2
S:S:C102 S:S:C181 7.28 0 No No 9 9 2 2
S:S:F110 S:S:I109 5.02 1 Yes Yes 5 6 1 1
S:S:I109 S:S:Y299 4.84 1 Yes Yes 6 7 1 1
S:S:I109 W:W:F31 11.3 1 Yes Yes 6 0 1 0
S:S:F110 S:S:Y114 11.35 1 Yes Yes 5 6 1 2
S:S:F110 S:S:Y264 2.06 1 Yes No 5 6 1 2
S:S:F110 W:W:F31 4.29 1 Yes Yes 5 0 1 0
S:S:F110 W:W:P32 4.33 1 Yes Yes 5 0 1 0
S:S:A161 S:S:Y114 5.34 1 Yes Yes 7 6 2 2
S:S:A161 S:S:V164 1.7 1 Yes No 7 4 2 1
S:S:R168 S:S:V164 11.77 1 Yes No 5 4 2 1
S:S:V164 W:W:P32 1.77 0 No Yes 4 0 1 0
S:S:L167 S:S:M183 5.65 0 No Yes 5 5 2 1
S:S:C181 S:S:Q180 4.58 0 No Yes 9 2 2 1
S:S:Q180 W:W:H26 2.47 1 Yes Yes 2 0 1 0
S:S:Y182 W:W:H26 3.27 0 No Yes 4 0 1 0
S:S:M183 S:S:Y185 5.99 1 Yes No 5 5 1 1
S:S:M183 W:W:L25 2.83 1 Yes No 5 0 1 0
S:S:M183 W:W:H26 7.88 1 Yes Yes 5 0 1 0
S:S:M183 W:W:P32 1.68 1 Yes Yes 5 0 1 0
S:S:Y185 W:W:L25 2.34 1 No No 5 0 1 0
S:S:F291 S:S:V267 3.93 1 Yes No 4 4 1 2
S:S:C294 S:S:V267 3.42 1 No No 6 4 2 2
S:S:D284 S:S:Y271 2.3 0 No No 4 4 2 1
S:S:L287 S:S:Y271 2.34 20 No No 4 4 2 1
S:S:Y271 W:W:C22 2.69 0 No No 4 0 1 0
S:S:D284 S:S:M288 5.54 0 No No 4 4 2 1
S:S:L285 S:S:M288 4.24 0 No No 3 4 2 1
S:S:M288 W:W:P24 1.68 0 No No 4 0 1 0
S:S:F291 S:S:P292 4.33 1 Yes Yes 4 4 1 1
S:S:C294 S:S:F291 5.59 1 No Yes 6 4 2 1
S:S:F291 S:S:T295 2.59 1 Yes No 4 5 1 1
S:S:F291 W:W:P30 4.33 1 Yes No 4 0 1 0
S:S:P292 W:W:R28 4.32 1 Yes No 4 0 1 0
S:S:P292 W:W:V29 3.53 1 Yes Yes 4 0 1 0
S:S:T295 W:W:V29 1.59 0 No Yes 5 0 1 0
S:S:S298 S:S:Y299 2.54 0 No Yes 7 7 2 1
S:S:Y299 W:W:F31 4.13 1 Yes Yes 7 0 1 0
S:S:C281 W:W:Q19 1.53 0 No No 8 0 1 0
S:S:D92 S:S:Y93 1.15 0 No Yes 6 4 2 1
S:S:D184 S:S:Y182 1.15 0 No No 3 4 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:K25 R:R:W24 10.44 0 No No 4 1 2 1
R:R:N289 R:R:W24 2.26 0 No No 2 1 2 1
L:L:R20 R:R:W24 9 0 No No 0 1 0 1
R:R:G28 R:R:I31 3.53 0 No Yes 3 6 2 1
R:R:I31 R:R:P32 5.08 8 Yes No 6 5 1 2
R:R:I31 R:R:I34 2.94 8 Yes No 6 5 1 2
R:R:I31 R:R:Y35 15.71 8 Yes Yes 6 7 1 1
R:R:I31 R:R:T89 3.04 8 Yes No 6 5 1 1
L:L:R28 R:R:I31 3.76 8 Yes Yes 0 6 0 1
R:R:I34 R:R:Y35 2.42 8 No Yes 5 7 2 1
R:R:C296 R:R:I34 3.27 8 No No 5 5 2 2
R:R:L82 R:R:Y35 3.52 8 Yes Yes 7 7 2 1
R:R:A86 R:R:Y35 2.67 8 No Yes 6 7 2 1
R:R:C296 R:R:Y35 2.69 8 No Yes 5 7 2 1
L:L:V29 R:R:Y35 13.88 0 No Yes 0 7 0 1
R:R:F78 R:R:I109 6.28 0 Yes No 6 6 2 1
R:R:A86 R:R:L82 1.58 8 No Yes 6 7 2 2
R:R:L84 R:R:W85 12.53 6 Yes Yes 6 6 2 1
R:R:W85 R:R:Y88 3.86 0 Yes Yes 6 5 1 2
R:R:C102 R:R:W85 3.92 6 Yes Yes 9 6 2 1
R:R:S105 R:R:W85 8.65 0 No Yes 5 6 2 1
L:L:H26 R:R:W85 3.17 0 Yes Yes 0 6 0 1
L:L:F31 R:R:W85 11.02 0 No Yes 0 6 0 1
R:R:Y88 R:R:Y93 4.96 0 Yes No 5 4 2 1
R:R:Q180 R:R:Y88 2.25 0 No Yes 2 5 2 2
L:L:R28 R:R:T89 11.64 8 Yes No 0 5 0 1
L:L:V29 R:R:T89 4.76 0 No No 0 5 0 1
L:L:S27 R:R:Y93 8.9 0 No No 0 4 0 1
L:L:R28 R:R:Y93 15.43 8 Yes No 0 4 0 1
R:R:C102 R:R:K103 4.85 6 Yes Yes 9 7 2 2
R:R:C102 R:R:C181 7.28 6 Yes Yes 9 9 2 2
R:R:K103 R:R:R168 14.85 6 Yes Yes 7 5 2 1
R:R:C181 R:R:K103 4.85 6 Yes Yes 9 7 2 2
R:R:F110 R:R:S106 5.28 49 Yes No 5 5 1 2
R:R:S106 R:R:V164 6.46 49 No No 5 4 2 2
L:L:F31 R:R:I109 12.56 0 No No 0 6 0 1
R:R:F110 R:R:Y114 3.09 49 Yes Yes 5 6 1 2
R:R:F110 R:R:V164 10.49 49 Yes No 5 4 1 2
L:L:P32 R:R:F110 4.33 0 No Yes 0 5 0 1
R:R:C181 R:R:R168 6.96 6 Yes Yes 9 5 2 1
R:R:M183 R:R:R168 3.72 0 No Yes 5 5 2 1
L:L:H26 R:R:R168 9.03 0 Yes Yes 0 5 0 1
R:R:Q180 R:R:Y182 5.64 0 No Yes 2 4 2 1
L:L:L25 R:R:Y182 9.38 0 No Yes 0 4 0 1
L:L:H26 R:R:Y182 3.27 0 Yes Yes 0 4 0 1
R:R:F291 R:R:Y264 8.25 0 Yes No 4 6 1 2
R:R:M288 R:R:Y271 8.38 0 No No 4 4 1 2
L:L:P24 R:R:M288 1.68 0 No No 0 4 0 1
R:R:F291 R:R:P292 4.33 0 Yes No 4 4 1 1
R:R:F291 R:R:T295 3.89 0 Yes No 4 5 1 1
L:L:P30 R:R:F291 5.78 0 No Yes 0 4 0 1
L:L:R28 R:R:P292 4.32 8 Yes No 0 4 0 1
L:L:V29 R:R:T295 1.59 0 No No 0 5 0 1
R:R:D184 R:R:Y182 1.15 0 No Yes 3 4 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7W0N
Class A
SubFamily Peptide
Type Apelin
SubType Apelin
Species Homo sapiens
Ligand Elabela
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 4.21
Date 2022-07-27
D.O.I. 10.1038/s41594-022-00797-5
Net Summary
Imin 1.58
Number of Linked Nodes 1165
Number of Links 1411
Number of Hubs 215
Number of Links mediated by Hubs 767
Number of Communities 51
Number of Nodes involved in Communities 356
Number of Links involved in Communities 477
Path Summary
Number Of Nodes in MetaPath 106
Number Of Links MetaPath 105
Number of Shortest Paths 1774415
Length Of Smallest Path 3
Average Path Length 44.7648
Length of Longest Path 94
Minimum Path Strength 1.145
Average Path Strength 5.52919
Maximum Path Strength 25.49
Minimum Path Correlation 0.7
Average Path Correlation 0.99167
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.38095
Average % Of Corr. Nodes 40.9506
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 39.08
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7W0N_Chain_A
CTLSAEDKA AVERSKMID RNLREDGEK AAREVKLLL LGAGESGKS 
TIVKQMKIT GIVETHFTF KDLHFKMFD VGGQRSERK KWIHCFEGV 
TAIIFCVAL SDYDLVLAE DEEMNRMHE SMKLFDSIC NNKWFTDTS 
IILFLNKKD LFEEKIKKS PLTICYPEY AGSNTYEEA AAYIQCQFE 
DLNKRKDTK EIYTHFTCA TDTKNVQFV FDAVTDVII KNNLKDCGL 
F


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7W0N_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7W0N_Chain_G
SNNTASIAQ ARKLVEQLK MEANIDRIK VSKAAADLM AYCEAHAKE 
DPLLTPVPA SENPFRE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtP35414
Sequence
>7W0N_Chain_S
WKSSGALIP AIYMLVFLL GTTGNGLVL WTVFRSSRE KRRSADIFI 
ASLAVADLT FVVTLPLWA TYTYRDYDW PFGTFFCKL SSYLIFVNM 
YASVFCLTG LSFDRYLAI VRPVANARL RLRVSGAVA TAVLWVLAA 
LLAMPVMVL RTTGDLENT TKVQCYMDY SMVATVSSE WAWEVGLGV 
SSTTVGFVV PFTIMLTCY FFIAQTIAG HFRKERIEG LRKRRRLLS 
IIVVLVVTF ALCWMPYHL VKTLYMLGS LLHWPCDFD LFLMNIFPY 
CTCISYVNS CLNPFLYAF FDPRFRQAC TS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP35414
Sequence
>7W0N_Chain_R
WKSSGALIP AIYMLVFLL GTTGNGLVL WTVFRSSRE KRRSADIFI 
ASLAVADLT FVVTLPLWA TYTYRDYDW PFGTFFCKL SSYLIFVNM 
YASVFCLTG LSFDRYLAI VRPVANARL RLRVSGAVA TAVLWVLAA 
LLAMPVMVL RTTGDLENT TKVQCYMDY SMVATVSSE WAWEVGLGV 
SSTTVGFVV PFTIMLTCY FFIAQTIAG HFRKERIEG LRKRRRLLS 
IIVVLVVTF ALCWMPYHL VKTLYMLGS LLHWPCDFD LFLMNIFPY 
CTCISYVNS CLNPFLYAF FDPRFRQAC T


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5VBLAPeptideApelinApelinHomo sapiensApelin Mimetic Peptide Agonist--2.62017-05-3110.1016/j.str.2017.04.008
6KNMAPeptideApelinApelinHomo sapiensJN241-9--3.22020-01-2910.1126/sciadv.aax7379
7SUSAPeptideApelinApelinHomo sapiensPubChem 122701908--2.72022-07-2710.1038/s41594-022-00797-5
7W0LAPeptideApelinApelinHomo sapiensPubChem 122701908-Gi1/&β;1/&γ;23.572022-07-2710.1038/s41594-022-00797-5
7W0MAPeptideApelinApelinHomo sapiensPubChem 122701908-Gi1/&β;1/&γ;23.712022-07-2710.1038/s41594-022-00797-5
7W0NAPeptideApelinApelinHomo sapiensElabela-Gi1/&β;1/&γ;24.212022-07-2710.1038/s41594-022-00797-5
7W0OAPeptideApelinApelinHomo sapiensElabela-Gi1/&β;1/&γ;23.782022-07-2710.1038/s41594-022-00797-5
7W0PAPeptideApelinApelinHomo sapiensElabela-Gi1/&β;1/&γ;23.162022-07-2710.1038/s41594-022-00797-5
8XZFAPeptideApelinApelinHomo sapiensWN561-Gi1/&β;1/&γ;232024-03-2010.1016/j.cell.2024.02.004
8XZGAPeptideApelinApelinHomo sapiensApelin-13-Gi1/&β;1/&γ;23.22024-03-2010.1016/j.cell.2024.02.004
8XZHAPeptideApelinApelinHomo sapiensMM07-Gi1/&β;1/&γ;22.062024-03-2010.1016/j.cell.2024.02.004
8XZJAPeptideApelinApelinHomo sapiensWN353-Gi1/&β;1/&γ;232024-03-2010.1016/j.cell.2024.02.004




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7W0N.zip



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