psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C1	L:L:P3	3.77	No	Yes	3	0	0
2	L:L:C1	L:L:C6	7.28	No	No	3	0	0
3	L:L:C1	R:R:Y185	5.38	No	Yes	0	0	5
4	L:L:C6	L:L:P3	5.65	No	Yes	3	0	0
5	L:L:P3	R:R:Y271	5.56	Yes	Yes	0	0	4
6	L:L:L5	R:R:Y271	18.76	No	Yes	0	0	4
7	L:L:H7	L:L:K8	3.93	No	No	0	0	0
8	L:L:H7	R:R:Q180	6.18	No	No	0	0	2
9	L:L:K8	R:R:Y93	21.5	No	No	0	0	4
10	L:L:G9	L:L:P10	4.06	No	Yes	0	0	0
11	L:L:?11	L:L:P10	6.02	Yes	Yes	1	0	0
12	L:L:P10	R:R:W85	13.51	Yes	Yes	1	0	6
13	L:L:P10	R:R:I109	6.77	Yes	Yes	1	0	6
14	L:L:?11	L:L:G12	7.84	Yes	No	0	0	0
15	L:L:?11	R:R:I109	5.23	Yes	Yes	1	0	6
16	L:L:?11	R:R:Y264	19.34	Yes	Yes	1	0	6
17	L:L:?11	R:R:T295	5.4	Yes	No	0	0	5
18	L:L:?11	R:R:Y299	5.37	Yes	Yes	1	0	7
19	L:L:G12	L:L:P13	4.06	No	No	0	0	0
20	L:L:P13	R:R:Y185	4.17	No	Yes	0	0	5
21	L:L:F14	R:R:L160	7.31	Yes	Yes	0	0	4
22	L:L:F14	R:R:P163	11.56	Yes	No	0	0	8
23	L:L:F14	R:R:L201	7.31	Yes	No	0	0	4
24	R:R:C19	R:R:C281	7.28	No	No	0	8	8
25	R:R:C281	R:R:Y21	6.72	No	Yes	0	8	4
26	R:R:D284	R:R:Y21	13.79	No	Yes	0	4	4
27	R:R:L285	R:R:Y21	3.52	No	Yes	0	3	4
28	R:R:M288	R:R:Y21	8.38	No	Yes	0	4	4
29	R:R:D23	R:R:Y93	4.6	No	No	0	5	4
30	R:R:D23	R:R:N289	6.73	No	No	0	5	2
31	R:R:N289	R:R:W24	35.03	No	No	0	2	1
32	R:R:L30	R:R:S26	6.01	No	No	0	5	3
33	R:R:I31	R:R:S27	4.64	Yes	No	4	6	3
34	R:R:S27	R:R:Y293	6.36	No	Yes	4	3	5
35	R:R:L30	R:R:Y293	5.86	No	Yes	0	5	5
36	R:R:I31	R:R:Y35	4.84	Yes	No	0	6	7
37	R:R:I31	R:R:T89	4.56	Yes	No	0	6	5
38	R:R:I31	R:R:Y293	6.04	Yes	Yes	4	6	5
39	R:R:P32	R:R:Y90	6.95	No	No	0	5	3
40	R:R:C296	R:R:I34	9.82	No	No	0	5	5
41	R:R:C296	R:R:Y35	4.03	No	No	0	5	7
42	R:R:M36	R:R:P83	5.03	No	No	0	3	9
43	R:R:V38	R:R:Y299	5.05	No	Yes	0	7	7
44	R:R:F39	R:R:T43	5.19	No	No	0	6	5
45	R:R:F39	R:R:P83	18.78	No	No	0	6	9
46	R:R:C303	R:R:G42	3.92	No	No	0	7	8
47	R:R:L76	R:R:T43	4.42	No	No	0	7	5
48	R:R:D75	R:R:N46	8.08	Yes	No	0	9	9
49	R:R:N46	R:R:P306	6.52	No	No	0	9	9
50	R:R:L324	R:R:L48	4.15	No	No	0	6	5
51	R:R:P306	R:R:V49	3.53	No	No	0	9	8
52	R:R:F311	R:R:V49	5.24	Yes	No	0	6	8
53	R:R:F54	R:R:L50	3.65	No	No	0	3	7
54	R:R:A72	R:R:L50	4.73	No	No	0	8	7
55	R:R:L50	R:R:V73	4.47	No	No	0	7	5
56	R:R:R55	R:R:W51	13	No	No	0	6	3
57	R:R:F316	R:R:T52	7.78	No	No	0	9	7
58	R:R:F54	R:R:V53	3.93	No	No	0	3	6
59	R:R:D65	R:R:V53	4.38	No	No	0	8	6
60	R:R:F54	R:R:R55	6.41	No	No	0	3	6
61	R:R:D65	R:R:R62	5.96	No	No	0	8	7
62	R:R:D313	R:R:R62	8.34	No	No	0	8	7
63	R:R:F67	R:R:I66	3.77	Yes	No	5	7	5
64	R:R:I66	R:R:T150	9.12	No	No	5	5	6
65	R:R:F67	R:R:L123	7.31	Yes	No	0	7	8
66	R:R:D126	R:R:F67	3.58	No	Yes	0	8	7
67	R:R:F67	R:R:T150	3.89	Yes	No	5	7	6
68	R:R:C119	R:R:S70	5.16	No	No	0	7	9
69	R:R:S70	R:R:W154	11.12	No	Yes	0	9	9
70	R:R:C119	R:R:L71	4.76	No	Yes	0	7	9
71	R:R:L120	R:R:L71	4.15	No	Yes	2	8	9
72	R:R:L71	R:R:N305	8.24	Yes	Yes	2	9	9
73	R:R:L71	R:R:Y309	3.52	Yes	Yes	2	9	9
74	R:R:D75	R:R:S302	11.78	Yes	No	0	9	8
75	R:R:D75	R:R:N305	9.42	Yes	Yes	0	9	9
76	R:R:L108	R:R:T77	5.9	No	No	0	4	7
77	R:R:N112	R:R:T77	8.77	No	No	0	8	7
78	R:R:F78	R:R:I109	7.54	Yes	Yes	1	6	6
79	R:R:F78	R:R:N112	6.04	Yes	No	0	6	8
80	R:R:F78	R:R:W261	4.01	Yes	Yes	1	6	9
81	R:R:F78	R:R:Y299	14.44	Yes	Yes	1	6	7
82	R:R:F78	R:R:S302	6.61	Yes	No	0	6	8
83	R:R:L82	R:R:V79	4.47	No	No	0	7	6
84	R:R:L84	R:R:T81	4.42	No	No	0	6	7
85	R:R:S105	R:R:T81	9.59	No	No	0	5	7
86	R:R:L82	R:R:Y299	15.24	No	Yes	0	7	7
87	R:R:F97	R:R:L84	4.87	Yes	No	0	6	6
88	R:R:W85	R:R:Y88	5.79	Yes	No	1	6	5
89	R:R:W85	R:R:W95	8.43	Yes	Yes	1	6	8
90	R:R:S105	R:R:W85	8.65	No	Yes	0	5	6
91	R:R:C181	R:R:W85	6.53	Yes	Yes	1	9	6
92	R:R:F97	R:R:T87	6.49	Yes	No	0	6	4
93	R:R:W95	R:R:Y88	9.65	Yes	No	1	8	5
94	R:R:T89	R:R:Y93	6.24	No	No	0	5	4
95	R:R:D94	R:R:K178	19.36	No	No	0	4	2
96	R:R:F97	R:R:W95	12.03	Yes	Yes	0	6	8
97	R:R:C102	R:R:W95	5.22	No	Yes	1	9	8
98	R:R:T170	R:R:W95	4.85	No	Yes	0	5	8
99	R:R:C181	R:R:W95	3.92	Yes	Yes	1	9	8
100	R:R:F97	R:R:P96	7.22	Yes	No	0	6	4
101	R:R:F101	R:R:F97	5.36	No	Yes	0	5	6
102	R:R:T170	R:R:T99	9.42	No	No	0	5	3
103	R:R:F100	R:R:F101	4.29	No	No	0	1	5
104	R:R:F100	R:R:L104	6.09	No	No	0	1	5
105	R:R:C102	R:R:C181	7.28	No	Yes	1	9	9
106	R:R:R168	R:R:S106	13.18	No	No	0	5	5
107	R:R:M162	R:R:Y107	4.79	No	No	0	4	5
108	R:R:M165	R:R:Y107	8.38	No	No	0	5	5
109	R:R:I109	R:R:Y299	6.04	Yes	Yes	1	6	7
110	R:R:F110	R:R:M113	6.22	Yes	No	0	5	7
111	R:R:F110	R:R:Y114	11.35	Yes	Yes	6	5	6
112	R:R:A161	R:R:F110	4.16	No	Yes	0	7	5
113	R:R:F110	R:R:V164	13.11	Yes	No	0	5	4
114	R:R:F110	R:R:S205	5.28	Yes	No	6	5	4
115	R:R:N112	R:R:V111	4.43	No	No	0	8	4
116	R:R:M113	R:R:W261	6.98	No	Yes	0	7	9
117	R:R:F118	R:R:Y114	4.13	Yes	Yes	0	5	6
118	R:R:L160	R:R:Y114	4.69	Yes	Yes	0	4	6
119	R:R:S205	R:R:Y114	6.36	No	Yes	6	4	6
120	R:R:A115	R:R:W154	7.78	No	Yes	0	7	9
121	R:R:F118	R:R:V117	3.93	Yes	Yes	0	5	7
122	R:R:P213	R:R:V117	3.53	No	Yes	0	9	7
123	R:R:F257	R:R:V117	5.24	Yes	Yes	1	8	7
124	R:R:V117	R:R:W261	3.68	Yes	Yes	1	7	9
125	R:R:F118	R:R:L153	6.09	Yes	No	0	5	6
126	R:R:F118	R:R:L156	4.87	Yes	No	0	5	4
127	R:R:C119	R:R:L153	4.76	No	No	0	7	6
128	R:R:L120	R:R:N305	4.12	No	Yes	2	8	9
129	R:R:L120	R:R:Y309	8.21	No	Yes	2	8	9
130	R:R:I216	R:R:T121	4.56	No	No	0	6	7
131	R:R:M217	R:R:T121	4.52	No	No	0	8	7
132	R:R:L123	R:R:Y309	3.52	No	Yes	0	8	9
133	R:R:M217	R:R:S124	6.13	No	No	0	8	9
134	R:R:C220	R:R:S124	5.16	No	No	0	6	9
135	R:R:S124	R:R:Y221	5.09	No	Yes	0	9	8
136	R:R:F125	R:R:L129	12.18	No	Yes	0	6	5
137	R:R:D126	R:R:R141	8.34	No	Yes	0	8	7
138	R:R:R127	R:R:Y221	8.23	No	Yes	0	9	8
139	R:R:R127	R:R:Y309	4.12	No	Yes	0	9	9
140	R:R:V132	R:R:Y128	13.88	No	No	0	7	8
141	R:R:C220	R:R:Y128	4.03	No	No	0	6	8
142	R:R:F223	R:R:Y128	6.19	No	No	0	5	8
143	R:R:L129	R:R:N137	5.49	Yes	No	0	5	6
144	R:R:L129	R:R:R141	3.64	Yes	Yes	0	5	7
145	R:R:A130	R:R:R141	5.53	No	Yes	0	8	7
146	R:R:I131	R:R:I224	8.83	No	No	0	8	8
147	R:R:T227	R:R:V132	6.35	No	No	0	4	7
148	R:R:A136	R:R:R133	4.15	No	No	0	4	6
149	R:R:N137	R:R:R133	3.62	No	No	0	6	6
150	R:R:L140	R:R:R143	4.86	No	No	0	4	3
151	R:R:L140	R:R:V144	5.96	No	No	0	4	4
152	R:R:L153	R:R:W154	6.83	No	Yes	0	6	9
153	R:R:L156	R:R:L160	8.3	No	Yes	0	4	4
154	R:R:M183	R:R:V164	4.56	No	No	0	5	4
155	R:R:L167	R:R:V188	8.94	No	No	0	5	2
156	R:R:C181	R:R:R168	6.96	Yes	No	0	9	5
157	R:R:M183	R:R:R168	7.44	No	No	0	5	5
158	R:R:T169	R:R:Y182	6.24	No	No	0	4	4
159	R:R:T170	R:R:V179	4.76	No	No	0	5	5
160	R:R:L173	R:R:N175	4.12	No	No	0	3	2
161	R:R:L173	R:R:Y182	5.86	No	No	0	3	4
162	R:R:K178	R:R:T176	12.01	No	Yes	0	2	3
163	R:R:Q180	R:R:T176	7.09	No	Yes	0	2	3
164	R:R:M183	R:R:Y185	9.58	No	Yes	0	5	5
165	R:R:D184	R:R:S186	5.89	No	No	0	3	5
166	R:R:E198	R:R:Y185	7.86	No	Yes	0	4	5
167	R:R:V188	R:R:W197	23.29	No	No	0	2	2
168	R:R:A189	R:R:W197	3.89	No	No	0	1	2
169	R:R:S193	R:R:T190	4.8	No	No	0	4	1
170	R:R:E194	R:R:V191	8.56	No	No	0	6	2
171	R:R:L201	R:R:W197	5.69	No	No	0	4	2
172	R:R:G200	R:R:V199	3.68	No	No	0	2	3
173	R:R:H265	R:R:T206	6.85	Yes	No	1	8	5
174	R:R:K268	R:R:T206	6.01	No	No	1	5	5
175	R:R:T206	R:R:T269	4.71	No	No	0	5	6
176	R:R:G209	R:R:P213	4.06	No	No	0	5	9
177	R:R:F210	R:R:F214	5.36	Yes	Yes	1	8	6
178	R:R:F210	R:R:F257	6.43	Yes	Yes	1	8	8
179	R:R:F210	R:R:M262	11.2	Yes	No	0	8	5
180	R:R:F210	R:R:H265	14.71	Yes	Yes	1	8	8
181	R:R:P213	R:R:V212	3.53	No	No	0	9	6
182	R:R:F214	R:R:L218	8.53	Yes	No	0	6	4
183	R:R:F214	R:R:F257	9.65	Yes	Yes	1	6	8
184	R:R:F257	R:R:M217	11.2	Yes	No	0	8	8
185	R:R:L218	R:R:V254	4.47	No	No	0	4	7
186	R:R:F223	R:R:T219	3.89	No	No	0	5	4
187	R:R:I250	R:R:Y221	4.84	No	Yes	0	7	8
188	R:R:L253	R:R:Y221	4.69	Yes	Yes	0	7	8
189	R:R:V254	R:R:Y221	3.79	No	Yes	0	7	8
190	R:R:F222	R:R:Q226	9.37	No	No	0	3	3
191	R:R:F223	R:R:Q226	3.51	No	No	0	5	3
192	R:R:F232	R:R:I228	6.28	Yes	Yes	7	4	8
193	R:R:I228	R:R:L246	7.14	Yes	No	7	8	7
194	R:R:I228	R:R:L247	4.28	Yes	No	0	8	6
195	R:R:F232	R:R:L246	4.87	Yes	No	7	4	7
196	R:R:E235	R:R:R233	6.98	No	No	0	4	4
197	R:R:K234	R:R:R243	8.66	No	No	0	3	6
198	R:R:E238	R:R:R236	4.65	No	No	0	4	2
199	R:R:E238	R:R:I237	5.47	No	No	0	4	3
200	R:R:I237	R:R:R241	6.26	No	No	0	3	4
201	R:R:F312	R:R:R245	17.1	No	No	0	6	7
202	R:R:I249	R:R:L253	5.71	No	Yes	0	7	7
203	R:R:F312	R:R:I249	18.84	No	No	0	6	7
204	R:R:L253	R:R:L308	4.15	Yes	No	0	7	8
205	R:R:L253	R:R:Y309	16.41	Yes	Yes	0	7	9
206	R:R:L308	R:R:T256	4.42	No	No	0	8	6
207	R:R:F257	R:R:W261	7.02	Yes	Yes	1	8	9
208	R:R:C260	R:R:N301	7.87	No	No	0	7	9
209	R:R:H265	R:R:W261	4.23	Yes	Yes	1	8	9
210	R:R:S298	R:R:W261	11.12	No	Yes	0	7	9
211	R:R:N301	R:R:W261	7.91	No	Yes	0	9	9
212	R:R:H265	R:R:Y264	10.89	Yes	Yes	1	8	6
213	R:R:K268	R:R:Y264	11.94	No	Yes	1	5	6
214	R:R:F291	R:R:Y264	6.19	Yes	Yes	0	4	6
215	R:R:H265	R:R:K268	3.93	Yes	No	1	8	5
216	R:R:L266	R:R:L270	4.15	No	No	0	6	5
217	R:R:L287	R:R:V267	4.47	No	No	0	4	4
218	R:R:F291	R:R:V267	3.93	Yes	No	0	4	4
219	R:R:C294	R:R:V267	5.12	No	No	0	6	4
220	R:R:D284	R:R:Y271	6.9	No	Yes	0	4	4
221	R:R:M288	R:R:Y271	8.38	No	Yes	0	4	4
222	R:R:G274	R:R:W279	4.22	No	Yes	0	3	1
223	R:R:F283	R:R:W279	28.06	No	Yes	0	3	1
224	R:R:F283	R:R:L287	9.74	No	No	0	3	4
225	R:R:I290	R:R:Y293	4.84	No	Yes	0	4	5
226	R:R:F291	R:R:P292	4.33	Yes	No	0	4	4
227	R:R:F291	R:R:T295	3.89	Yes	No	0	4	5
228	R:R:N301	R:R:N305	5.45	No	Yes	0	9	9
229	R:R:A310	R:R:F316	4.16	No	No	0	6	9
230	R:R:F311	R:R:F316	5.36	Yes	No	0	6	9
231	R:R:F311	R:R:R317	4.28	Yes	No	0	6	8
232	R:R:C320	R:R:F311	6.98	No	Yes	0	6	6
233	R:R:D313	R:R:P314	4.83	No	No	0	8	5
234	R:R:D313	R:R:R315	11.91	No	No	0	8	7
235	R:R:G202	R:R:M272	3.49	No	No	0	5	5
236	R:R:L324	R:R:W51	3.42	No	No	0	6	3
237	R:R:L270	R:R:W279	3.42	No	Yes	0	5	1
238	R:R:L277	R:R:W279	3.42	No	Yes	0	1	1
239	R:R:I31	R:R:P32	3.39	Yes	No	0	6	5
240	R:R:I31	R:R:P292	3.39	Yes	No	0	6	4
241	R:R:A72	R:R:V49	3.39	No	No	0	8	8
242	R:R:A69	R:R:V53	3.39	No	No	0	5	6
243	R:R:E194	R:R:Y185	3.37	No	Yes	0	6	5
244	R:R:M262	R:R:P263	3.35	No	No	0	5	9
245	R:R:E198	R:R:W195	3.27	No	No	0	4	2
246	R:R:A310	R:R:I68	3.25	No	No	0	6	8
247	R:R:F307	R:R:F311	3.22	No	Yes	0	6	6
248	R:R:F232	R:R:R243	3.21	Yes	No	0	4	6
249	R:R:C303	R:R:L41	3.17	No	No	0	7	5
250	R:R:T207	R:R:V208	3.17	No	No	0	3	5
251	R:R:M323	R:R:S56	3.07	No	No	0	5	5
252	R:R:I224	R:R:V132	3.07	No	No	0	8	7
253	R:R:I249	R:R:V252	3.07	No	No	0	7	5
254	R:R:F67	R:R:G146	3.01	Yes	No	0	7	7
255	R:R:K103	R:R:T99	3	No	No	0	7	3
256	R:R:L129	R:R:S145	3	Yes	No	0	5	4
257	R:R:L76	R:R:V80	2.98	No	No	0	7	4
258	R:R:L159	R:R:V155	2.98	No	No	0	4	4
259	R:R:L160	R:R:V208	2.98	Yes	No	0	4	5
260	R:R:L167	R:R:V166	2.98	No	No	0	5	4
261	R:R:L259	R:R:V255	2.98	No	No	0	5	4
262	R:R:L304	R:R:V300	2.98	No	No	0	6	5
263	R:R:L285	R:R:T22	2.95	No	No	0	3	4
264	R:R:D75	R:R:S116	2.94	Yes	No	0	9	9
265	R:R:I224	R:R:I228	2.94	No	Yes	0	8	8
266	R:R:N175	R:R:T176	2.92	No	Yes	0	2	3
267	R:R:D184	R:R:T169	2.89	No	No	0	3	4
268	L:L:P3	L:L:R2	2.88	Yes	No	0	0	0
269	R:R:P96	R:R:R91	2.88	No	No	0	4	3
270	R:R:E198	R:R:V199	2.85	No	No	0	4	3
271	R:R:L167	R:R:M187	2.83	No	No	0	5	2
272	R:R:Q318	R:R:T321	2.83	No	No	0	6	4
273	R:R:G98	R:R:W95	2.81	No	Yes	0	8	8
274	R:R:L37	R:R:L41	2.77	No	No	0	5	5
275	R:R:A149	R:R:F67	2.77	No	Yes	0	5	7
276	R:R:L129	R:R:L140	2.77	Yes	No	0	5	4
277	R:R:A258	R:R:F214	2.77	No	Yes	0	5	6
278	R:R:A229	R:R:R243	2.77	No	No	0	4	6
279	R:R:L304	R:R:L308	2.77	No	No	0	6	8
280	R:R:P280	R:R:W279	2.7	No	Yes	0	4	1
281	R:R:A86	R:R:Y35	2.67	No	No	0	6	7
282	R:R:A161	R:R:Y107	2.67	No	No	0	7	5
283	L:L:F14	R:R:S204	2.64	Yes	No	0	0	4
284	R:R:R141	R:R:S63	2.64	Yes	No	0	7	6
285	R:R:A74	R:R:W154	2.59	No	Yes	0	8	9
286	R:R:F286	R:R:I290	2.51	No	No	0	1	4
287	R:R:F232	R:R:K242	2.48	Yes	No	0	4	5
288	R:R:F39	R:R:L40	2.44	No	No	0	6	5
289	R:R:L142	R:R:R141	2.43	No	Yes	0	6	7
290	L:L:R2	L:L:R4	2.13	No	No	0	0	0
291	L:L:P13	R:R:G202	2.03	No	No	0	0	5
292	R:R:G45	R:R:P306	2.03	No	No	0	8	9
293	R:R:G28	R:R:S27	1.86	No	No	0	3	3
294	R:R:G200	R:R:V203	1.84	No	No	0	2	4
295	R:R:G45	R:R:T44	1.82	No	No	0	8	4
296	R:R:A115	R:R:A157	1.79	No	No	0	7	7
297	R:R:C303	R:R:V38	1.71	No	No	0	7	7
298	R:R:A64	R:R:S63	1.71	No	No	0	8	6
299	R:R:A189	R:R:S193	1.71	No	No	0	1	4
300	R:R:A158	R:R:V111	1.7	No	No	0	4	4
301	R:R:C325	R:R:T321	1.69	No	No	0	1	4
302	R:R:L82	R:R:P83	1.64	No	No	0	7	9
303	R:R:E238	R:R:G239	1.64	No	No	0	4	4
304	R:R:C260	R:R:I297	1.64	No	No	0	7	6
305	R:R:S192	R:R:S193	1.63	No	No	0	2	4
306	R:R:A147	R:R:I66	1.62	No	No	0	4	5
307	R:R:V211	R:R:V212	1.6	No	No	0	4	6
308	R:R:V251	R:R:V255	1.6	No	No	0	3	4
309	R:R:T215	R:R:V211	1.59	No	No	0	2	4
310	R:R:A225	R:R:L247	1.58	No	No	0	5	6
311	R:R:F67	R:R:G122	1.51	Yes	No	0	7	6
312	R:R:L273	R:R:T269	1.47	No	No	0	4	6
313	R:R:G171	R:R:Y182	1.45	No	No	0	1	4
314	R:R:D172	R:R:T176	1.45	No	Yes	0	1	3
315	R:R:P134	R:R:R133	1.44	No	No	0	8	6
316	R:R:Q318	R:R:S322	1.44	No	No	0	6	5
317	R:R:I237	R:R:L240	1.43	No	No	0	3	4
318	R:R:E174	R:R:T177	1.41	No	No	0	2	5
319	R:R:K234	R:R:L240	1.41	No	No	0	3	4
320	R:R:L276	R:R:L277	1.38	No	No	0	1	1
321	R:R:H231	R:R:T227	1.37	No	No	0	5	4
322	R:R:E235	R:R:K234	1.35	No	No	0	4	3
323	R:R:D172	R:R:E174	1.3	No	No	0	1	2
324	R:R:M323	R:R:W51	1.16	No	No	0	5	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:P3	4.465	4	3	0
2	L:L:P10	7.59	4	1	0
3	L:L:?11	8.2	6	1	0
4	L:L:F14	7.205	4	0	0
5	R:R:Y21	8.1025	4	0	4
6	R:R:I31	4.47667	6	4	6
7	R:R:F67	3.69143	7	5	7
8	R:R:L71	5.1675	4	2	9
9	R:R:D75	8.055	4	0	9
10	R:R:F78	7.728	5	1	6
11	R:R:W85	8.582	5	1	6
12	R:R:W95	6.70143	7	1	8
13	R:R:F97	7.194	5	0	6
14	R:R:I109	6.395	4	1	6
15	R:R:F110	8.024	5	6	5
16	R:R:Y114	6.6325	4	6	6
17	R:R:V117	4.095	4	1	7
18	R:R:F118	4.755	4	0	5
19	R:R:L129	5.416	5	0	5
20	R:R:R141	4.516	5	0	7
21	R:R:W154	7.08	4	0	9
22	R:R:L160	5.82	4	0	4
23	R:R:T176	5.8675	4	0	3
24	R:R:C181	6.1725	4	1	9
25	R:R:Y185	6.072	5	0	5
26	R:R:F210	9.425	4	1	8
27	R:R:F214	6.5775	4	1	6
28	R:R:Y221	5.328	5	0	8
29	R:R:I228	5.16	4	7	8
30	R:R:F232	4.21	4	7	4
31	R:R:L253	7.74	4	0	7
32	R:R:F257	7.908	5	1	8
33	R:R:W261	6.42143	7	1	9
34	R:R:Y264	12.09	4	1	6
35	R:R:H265	8.122	5	1	8
36	R:R:Y271	9.9	4	0	4
37	R:R:W279	8.364	5	0	1
38	R:R:F291	4.585	4	0	4
39	R:R:Y293	5.775	4	4	5
40	R:R:Y299	9.228	5	1	7
41	R:R:N305	6.8075	4	2	9
42	R:R:Y309	7.156	5	2	9
43	R:R:F311	5.016	5	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C1	L:L:P3	29.0673	3.77	No	Yes	3	0	0
2	L:L:P3	R:R:Y271	24.103	5.56	Yes	Yes	0	0	4
3	L:L:C1	R:R:Y185	32.4408	5.38	No	Yes	0	0	5
4	L:L:P13	R:R:Y185	22.7642	4.17	No	Yes	0	0	5
5	L:L:G12	L:L:P13	31.1057	4.06	No	No	0	0	0
6	L:L:?11	L:L:G12	34.1444	7.84	Yes	No	0	0	0
7	L:L:?11	R:R:Y264	36.8823	19.34	Yes	Yes	1	0	6
8	R:R:F291	R:R:Y264	90.4099	6.19	Yes	Yes	0	4	6
9	R:R:F291	R:R:P292	89.4396	4.33	Yes	No	0	4	4
10	R:R:I31	R:R:P292	87.0816	3.39	Yes	No	0	6	4
11	R:R:I31	R:R:T89	53.2794	4.56	Yes	No	0	6	5
12	R:R:T89	R:R:Y93	50.8086	6.24	No	No	0	5	4
13	L:L:K8	R:R:Y93	41.0342	21.5	No	No	0	0	4
14	L:L:H7	L:L:K8	38.5258	3.93	No	No	0	0	0
15	L:L:?11	R:R:T295	31.226	5.4	Yes	No	0	0	5
16	R:R:F291	R:R:T295	28.774	3.89	Yes	No	0	4	5
17	L:L:H7	R:R:Q180	36.0098	6.18	No	No	0	0	2
18	L:L:?11	L:L:P10	13.1102	6.02	Yes	Yes	1	0	0
19	R:R:M183	R:R:Y185	24.8891	9.58	No	Yes	0	5	5
20	L:L:?11	R:R:I109	24.6709	5.23	Yes	Yes	1	0	6
21	L:L:?11	R:R:Y299	33.6141	5.37	Yes	Yes	1	0	7
22	R:R:M183	R:R:V164	27.1155	4.56	No	No	0	5	4
23	R:R:F110	R:R:V164	28.2475	13.11	Yes	No	0	5	4
24	R:R:F110	R:R:Y114	21.903	11.35	Yes	Yes	6	5	6
25	R:R:L160	R:R:Y114	30.4814	4.69	Yes	Yes	0	4	6
26	L:L:F14	R:R:L160	38.6198	7.31	Yes	Yes	0	0	4
27	L:L:F14	R:R:L201	29.8195	7.31	Yes	No	0	0	4
28	R:R:D284	R:R:Y271	10.4701	6.9	No	Yes	0	4	4
29	R:R:M288	R:R:Y271	10.3573	8.38	No	Yes	0	4	4
30	R:R:I31	R:R:Y293	12.9898	6.04	Yes	Yes	4	6	5
31	R:R:I31	R:R:Y35	10.4363	4.84	Yes	No	0	6	7
32	R:R:L82	R:R:Y299	17.8676	15.24	No	Yes	0	7	7
33	R:R:L82	R:R:P83	13.9489	1.64	No	No	0	7	9
34	R:R:V38	R:R:Y299	10	5.05	No	Yes	0	7	7
35	R:R:F39	R:R:P83	10	18.78	No	No	0	6	9
36	R:R:F78	R:R:I109	49.3005	7.54	Yes	Yes	1	6	6
37	R:R:F78	R:R:S302	74.7687	6.61	Yes	No	0	6	8
38	R:R:D75	R:R:S302	73.4261	11.78	Yes	No	0	9	8
39	R:R:F78	R:R:Y299	42.5837	14.44	Yes	Yes	1	6	7
40	R:R:D75	R:R:N46	100	8.08	Yes	No	0	9	9
41	R:R:N46	R:R:P306	96.7582	6.52	No	No	0	9	9
42	R:R:P306	R:R:V49	86.9876	3.53	No	No	0	9	8
43	R:R:A72	R:R:V49	57.2696	3.39	No	No	0	8	8
44	R:R:A72	R:R:L50	53.93	4.73	No	No	0	8	7
45	R:R:F54	R:R:L50	47.2283	3.65	No	No	0	3	7
46	R:R:F54	R:R:R55	20.2896	6.41	No	No	0	3	6
47	R:R:R55	R:R:W51	16.8672	13	No	No	0	6	3
48	R:R:F311	R:R:V49	27.4652	5.24	Yes	No	0	6	8
49	R:R:F311	R:R:F316	13.7909	5.36	Yes	No	0	6	9
50	R:R:F54	R:R:V53	23.8436	3.93	No	No	0	3	6
51	R:R:D65	R:R:V53	17.0064	4.38	No	No	0	8	6
52	R:R:D65	R:R:R62	13.7006	5.96	No	No	0	8	7
53	R:R:D313	R:R:R62	10.2633	8.34	No	No	0	8	7
54	R:R:F110	R:R:M113	32.768	6.22	Yes	No	0	5	7
55	R:R:M113	R:R:W261	33.6668	6.98	No	Yes	0	7	9
56	R:R:N301	R:R:W261	69.8571	7.91	No	Yes	0	9	9
57	R:R:N301	R:R:N305	68.2437	5.45	No	Yes	0	9	9
58	R:R:L71	R:R:N305	50.425	8.24	Yes	Yes	2	9	9
59	R:R:L71	R:R:Y309	54.8477	3.52	Yes	Yes	2	9	9
60	R:R:L123	R:R:Y309	65.1974	3.52	No	Yes	0	8	9
61	R:R:F67	R:R:L123	62.61	7.31	Yes	No	0	7	8
62	R:R:F118	R:R:Y114	26.2091	4.13	Yes	Yes	0	5	6
63	R:R:F118	R:R:L153	21.9744	6.09	Yes	No	0	5	6
64	R:R:C119	R:R:L153	17.9428	4.76	No	No	0	7	6
65	R:R:C119	R:R:L71	19.733	4.76	No	Yes	0	7	9
66	R:R:L120	R:R:N305	43.3923	4.12	No	Yes	2	8	9
67	R:R:L120	R:R:Y309	42.7529	8.21	No	Yes	2	8	9
68	R:R:D126	R:R:F67	44.0354	3.58	No	Yes	0	8	7
69	R:R:F78	R:R:N112	12.689	6.04	Yes	No	0	6	8
70	R:R:F97	R:R:W95	14.7913	12.03	Yes	Yes	0	6	8
71	R:R:Q180	R:R:T176	33.4863	7.09	No	Yes	0	2	3
72	R:R:V117	R:R:W261	30.3836	3.68	Yes	Yes	1	7	9
73	R:R:F118	R:R:V117	33.0312	3.93	Yes	Yes	0	5	7
74	R:R:F257	R:R:W261	39.3569	7.02	Yes	Yes	1	8	9
75	R:R:F118	R:R:L156	18.3941	4.87	Yes	No	0	5	4
76	R:R:L156	R:R:L160	17.3035	8.3	No	Yes	0	4	4
77	R:R:F257	R:R:M217	52.4144	11.2	Yes	No	0	8	8
78	R:R:M217	R:R:S124	49.5713	6.13	No	No	0	8	9
79	R:R:C220	R:R:S124	57.548	5.16	No	No	0	6	9
80	R:R:S124	R:R:Y221	34.1444	5.09	No	Yes	0	9	8
81	R:R:D126	R:R:R141	41.3426	8.34	No	Yes	0	8	7
82	R:R:L129	R:R:R141	27.751	3.64	Yes	Yes	0	5	7
83	R:R:R127	R:R:Y221	13.9639	8.23	No	Yes	0	9	8
84	R:R:R127	R:R:Y309	14.9643	4.12	No	Yes	0	9	9
85	R:R:C220	R:R:Y128	55.581	4.03	No	No	0	6	8
86	R:R:V132	R:R:Y128	45.6337	13.88	No	No	0	7	8
87	R:R:L129	R:R:N137	11.1884	5.49	Yes	No	0	5	6
88	R:R:I224	R:R:V132	39.575	3.07	No	No	0	8	7
89	R:R:L201	R:R:W197	26.871	5.69	No	No	0	4	2
90	R:R:V188	R:R:W197	12.0158	23.29	No	No	0	2	2
91	R:R:N175	R:R:T176	18.1873	2.92	No	Yes	0	2	3
92	R:R:L173	R:R:N175	15.6111	4.12	No	No	0	3	2
93	R:R:L173	R:R:Y182	13.0275	5.86	No	No	0	3	4
94	R:R:A189	R:R:W197	12.0158	3.89	No	No	0	1	2
95	R:R:H265	R:R:Y264	70.7785	10.89	Yes	Yes	1	8	6
96	R:R:F210	R:R:H265	17.9541	14.71	Yes	Yes	1	8	8
97	R:R:L253	R:R:Y221	23.8624	4.69	Yes	Yes	0	7	8
98	R:R:L253	R:R:Y309	33.5427	16.41	Yes	Yes	0	7	9
99	R:R:I224	R:R:I228	35.4983	2.94	No	Yes	0	8	8
100	R:R:F232	R:R:I228	27.4426	6.28	Yes	Yes	7	4	8
101	R:R:F232	R:R:R243	23.4524	3.21	Yes	No	0	4	6
102	R:R:K234	R:R:R243	19.2554	8.66	No	No	0	3	6
103	R:R:K234	R:R:L240	12.9033	1.41	No	No	0	3	4
104	R:R:I237	R:R:L240	10.771	1.43	No	No	0	3	4
105	R:R:I249	R:R:L253	14.3024	5.71	No	Yes	0	7	7
106	R:R:L253	R:R:L308	14.2911	4.15	Yes	No	0	7	8
107	R:R:F291	R:R:V267	28.4167	3.93	Yes	No	0	4	4
108	R:R:L287	R:R:V267	23.317	4.47	No	No	0	4	4
109	R:R:F283	R:R:L287	20.7559	9.74	No	No	0	3	4
110	R:R:F283	R:R:W279	18.1873	28.06	No	Yes	0	3	1
111	L:L:P10	R:R:W85	35.1072	13.51	Yes	Yes	1	0	6
112	R:R:H265	R:R:W261	61.0305	4.23	Yes	Yes	1	8	9
113	R:R:F78	R:R:W261	59.5826	4.01	Yes	Yes	1	6	9
114	R:R:D75	R:R:N305	66.2843	9.42	Yes	Yes	0	9	9
115	R:R:W85	R:R:W95	23.2493	8.43	Yes	Yes	1	6	8
116	R:R:F210	R:R:F257	13.6969	6.43	Yes	Yes	1	8	8
117	L:L:P10	R:R:I109	25.4983	6.77	Yes	Yes	1	0	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:C1	R:R:Y185	5.38	3	No	Yes	0	5	0	1
L:L:P3	R:R:Y271	5.56	3	Yes	Yes	0	4	0	1
L:L:L5	R:R:Y271	18.76	0	No	Yes	0	4	0	1
L:L:H7	R:R:Q180	6.18	0	No	No	0	2	0	1
L:L:K8	R:R:Y93	21.5	0	No	No	0	4	0	1
L:L:P10	R:R:W85	13.51	1	Yes	Yes	0	6	0	1
L:L:P10	R:R:I109	6.77	1	Yes	Yes	0	6	0	1
L:L:?11	R:R:I109	5.23	1	Yes	Yes	0	6	0	1
L:L:?11	R:R:Y264	19.34	1	Yes	Yes	0	6	0	1
L:L:?11	R:R:T295	5.4	1	Yes	No	0	5	0	1
L:L:?11	R:R:Y299	5.37	1	Yes	Yes	0	7	0	1
L:L:P13	R:R:Y185	4.17	0	No	Yes	0	5	0	1
L:L:F14	R:R:L160	7.31	0	Yes	Yes	0	4	0	1
L:L:F14	R:R:P163	11.56	0	Yes	No	0	8	0	1
L:L:F14	R:R:L201	7.31	0	Yes	No	0	4	0	1
R:R:D23	R:R:Y93	4.6	0	No	No	5	4	2	1
R:R:V38	R:R:Y299	5.05	0	No	Yes	7	7	2	1
R:R:F78	R:R:I109	7.54	1	Yes	Yes	6	6	2	1
R:R:F78	R:R:Y299	14.44	1	Yes	Yes	6	7	2	1
R:R:L82	R:R:Y299	15.24	0	No	Yes	7	7	2	1
R:R:W85	R:R:Y88	5.79	1	Yes	No	6	5	1	2
R:R:W85	R:R:W95	8.43	1	Yes	Yes	6	8	1	2
R:R:S105	R:R:W85	8.65	0	No	Yes	5	6	2	1
R:R:C181	R:R:W85	6.53	1	Yes	Yes	9	6	2	1
R:R:W95	R:R:Y88	9.65	1	Yes	No	8	5	2	2
R:R:T89	R:R:Y93	6.24	0	No	No	5	4	2	1
R:R:C181	R:R:W95	3.92	1	Yes	Yes	9	8	2	2
R:R:I109	R:R:Y299	6.04	1	Yes	Yes	6	7	1	1
R:R:L160	R:R:Y114	4.69	0	Yes	Yes	4	6	1	2
R:R:L156	R:R:L160	8.3	0	No	Yes	4	4	2	1
R:R:Q180	R:R:T176	7.09	0	No	Yes	2	3	1	2
R:R:M183	R:R:Y185	9.58	0	No	Yes	5	5	2	1
R:R:E198	R:R:Y185	7.86	0	No	Yes	4	5	2	1
R:R:L201	R:R:W197	5.69	0	No	No	4	2	1	2
R:R:H265	R:R:Y264	10.89	1	Yes	Yes	8	6	2	1
R:R:K268	R:R:Y264	11.94	1	No	Yes	5	6	2	1
R:R:F291	R:R:Y264	6.19	0	Yes	Yes	4	6	2	1
R:R:H265	R:R:K268	3.93	1	Yes	No	8	5	2	2
R:R:D284	R:R:Y271	6.9	0	No	Yes	4	4	2	1
R:R:M288	R:R:Y271	8.38	0	No	Yes	4	4	2	1
R:R:F291	R:R:T295	3.89	0	Yes	No	4	5	2	1
R:R:G202	R:R:M272	3.49	0	No	No	5	5	1	2
R:R:E194	R:R:Y185	3.37	0	No	Yes	6	5	2	1
R:R:L160	R:R:V208	2.98	0	Yes	No	4	5	1	2
L:L:F14	R:R:S204	2.64	0	Yes	No	0	4	0	1
L:L:P13	R:R:G202	2.03	0	No	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XZF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.51
Number of Linked Nodes	296
Number of Links	324
Number of Hubs	43
Number of Links mediated by Hubs	161
Number of Communities	7
Number of Nodes involved in Communities	38
Number of Links involved in Communities	50

Path Summary
Number Of Nodes in MetaPath	118
Number Of Links MetaPath	117
Number of Shortest Paths	94417
Length Of Smallest Path	3
Average Path Length	14.3986
Length of Longest Path	33
Minimum Path Strength	1.355
Average Path Strength	6.63104
Maximum Path Strength	20.88
Minimum Path Correlation	0.7
Average Path Correlation	0.930528
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	50.4318
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.6368
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • apelin receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • developmental process • heart development • multicellular organism development • multicellular organismal process • anatomical structure development • animal organ development • circulatory system development • system development • atrioventricular valve development • heart valve development • cardiac chamber morphogenesis • heart morphogenesis • ventricular septum development • anatomical structure morphogenesis • cardiac septum development • cardiac septum morphogenesis • ventricular septum morphogenesis • cardiac chamber development • animal organ morphogenesis • cardiac ventricle development • regulation of body fluid levels • regulation of biological quality • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • tube morphogenesis • anatomical structure formation involved in morphogenesis • blood vessel development • regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis • positive regulation of cell population proliferation • endothelial cell proliferation • positive regulation of biological process • positive regulation of endothelial cell proliferation • epithelial cell proliferation • positive regulation of cellular process • positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis • cell population proliferation • blood vessel endothelial cell proliferation involved in sprouting angiogenesis • positive regulation of epithelial cell proliferation • sprouting angiogenesis • regulation of endothelial cell proliferation • regulation of cell population proliferation • regulation of epithelial cell proliferation • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • regulation of metabolic process • embryonic morphogenesis • embryo development • gastrulation • mesenchyme morphogenesis • endocardial cushion morphogenesis • mesenchyme development • tissue development • endocardial cushion formation • tissue morphogenesis • endocardial cushion development • artery development • aorta development • regulation of localization • negative adaptation of signaling pathway • regulation of G protein-coupled receptor internalization • receptor internalization • negative regulation of biological process • regulation of signal transduction • regulation of receptor internalization • vesicle-mediated transport • negative regulation of G protein-coupled receptor signaling pathway • localization • positive regulation of endocytosis • regulation of G protein-coupled receptor signaling pathway • positive regulation of receptor-mediated endocytosis • positive regulation of G protein-coupled receptor internalization • establishment of localization • positive regulation of receptor internalization • regulation of response to stimulus • adaptation of signaling pathway • receptor-mediated endocytosis • import into cell • regulation of cellular component organization • positive regulation of cellular component organization • transport • negative regulation of signaling • desensitization of G protein-coupled receptor signaling pathway • negative regulation of cell communication • cellular component organization • negative regulation of cellular process • cellular component organization or biogenesis • regulation of endocytosis • G protein-coupled receptor internalization • regulation of signaling • regulation of transport • negative regulation of response to stimulus • regulation of receptor-mediated endocytosis • regulation of vesicle-mediated transport • negative regulation of signal transduction • positive regulation of transport • regulation of cell communication • endocytosis • cellular developmental process • vasculogenesis • cell differentiation • regulation of developmental process • regulation of vasculature development • positive regulation of developmental process • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • positive regulation of angiogenesis • positive regulation of vasculature development • regulation of angiogenesis • positive regulation of multicellular organismal process • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • venous blood vessel development • regulation of calcium ion transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • intracellular calcium ion homeostasis • calcium ion transport • positive regulation of monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation homeostasis • monoatomic cation transport • intracellular monoatomic ion homeostasis • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • inorganic ion transmembrane transport • inorganic cation transmembrane transport • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • chemical homeostasis • cellular localization • inorganic ion homeostasis • homeostatic process • monoatomic ion transmembrane transport • calcium ion homeostasis • regulation of monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • metal ion transport • maintenance of location in cell • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • monoatomic ion transport • intracellular chemical homeostasis • positive regulation of release of sequestered calcium ion into cytosol • regulation of metal ion transport • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • sequestering of calcium ion • cellular homeostasis • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • negative regulation of muscle adaptation • system process • striated muscle adaptation • negative regulation of muscle hypertrophy • regulation of system process • regulation of muscle hypertrophy • regulation of cardiac muscle hypertrophy in response to stress • muscle adaptation • cardiac muscle adaptation • regulation of response to stress • response to stress • cardiac muscle hypertrophy • cardiac muscle hypertrophy in response to stress • muscle hypertrophy • regulation of muscle adaptation • negative regulation of cardiac muscle hypertrophy in response to stress • striated muscle hypertrophy • regulation of muscle system process • muscle system process • regulation of cardiac muscle hypertrophy • negative regulation of cardiac muscle adaptation • negative regulation of multicellular organismal process • regulation of cardiac muscle adaptation • negative regulation of cardiac muscle hypertrophy • muscle hypertrophy in response to stress • negative regulation of intracellular signal transduction • intracellular signal transduction • cAMP-mediated signaling • regulation of intracellular signal transduction • intracellular signaling cassette • negative regulation of cAMP-mediated signaling • regulation of cAMP-mediated signaling • adult heart development • negative regulation of metabolic process • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of macromolecule metabolic process • positive regulation of cardiac muscle hypertrophy • positive regulation of cardiac muscle hypertrophy in response to stress • positive regulation of response to stimulus • positive regulation of muscle adaptation • positive regulation of cardiac muscle adaptation • positive regulation of muscle hypertrophy • smooth muscle cell differentiation • muscle cell differentiation • muscle structure development • vascular associated smooth muscle cell differentiation • coronary vasculature development • gap junction assembly • regulation of gap junction assembly • regulation of cellular component biogenesis • cellular component biogenesis • regulation of cell junction assembly • cell junction organization • cellular component assembly • cell junction assembly • cell-cell junction assembly • cell-cell junction organization • pattern specification process • embryonic heart tube development • embryonic heart tube morphogenesis • heart looping • determination of bilateral symmetry • epithelial tube morphogenesis • embryonic organ development • determination of left/right symmetry • specification of symmetry • embryonic organ morphogenesis • epithelium development • morphogenesis of an epithelium • determination of heart left/right asymmetry • regionalization • left/right pattern formation • cell periphery • cellular anatomical structure • plasma membrane • membrane • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cell cycle • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	MED
PDB Residues	L:L:?11
Environment Details	Open EMBL-EBI Page
Code	MED
Name	D-Methionine
Synonyms	D-Methionine
Identifier
Formula	C5 H11 N O2 S
Molecular Weight	149.211
SMILES
PubChem	6992109
Formal Charge	0
Total Atoms	20
Total Chiral Atoms	1
Total Bonds	19
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35414
Sequence	>8XZF_nogp_Chain_R E C E Y T D W K S S G A L I P A I Y M L V F L L G T T G N G L V L W T V F R S R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D Y D W P F G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R P V A N A R L R L R V S G A V A T A V L W V L A A L L A M P V M V L R T T G D L E N T T K V Q C Y M D Y S M V A T V S S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R K E R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L L H W P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R F R Q A C T S M L C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8Z74	A	Peptide	Apelin	Apelin	Homo sapiens	Agonistic antibody	-	-	3.01	2025-01-22	10.1038/s41467-024-55555-6
	8XQJ	A	Peptide	Apelin	Apelin	Homo sapiens	JN241	-	-	2.95	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQI	A	Peptide	Apelin	Apelin	Homo sapiens	-	-	-	3.25	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8Z7J	A	Peptide	Apelin	Apelin	Homo sapiens	Agonistic antibody	-	Gi1/β1/γ2	3.12	2025-01-22	10.1038/s41467-024-55555-6
	8Z7J (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Agonistic antibody	-		3.12	2025-01-22	10.1038/s41467-024-55555-6
	8XQF	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-	Gi1/β1/γ2	3.13	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQF (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-		3.13	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQE	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-	Gi1/β1/γ2	3.48	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQE (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-		3.48	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8S4D	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-	-	2.58	2024-12-04	doi.org/10.1038/s41467-024-55381-w
	8XZJ	A	Peptide	Apelin	Apelin	Homo sapiens	WN353	-	Gi1/β1/γ2	3	2024-03-20	10.1016/j.cell.2024.02.004
	8XZJ (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	WN353	-		3	2024-03-20	10.1016/j.cell.2024.02.004
	8XZI	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-	Gi1/β1/γ2	2.7	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZI (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-		2.7	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZH	A	Peptide	Apelin	Apelin	Homo sapiens	MM07	-	Gi1/β1/γ2	2.06	2024-03-20	10.1016/j.cell.2024.02.004
	8XZH (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	MM07	-		2.06	2024-03-20	10.1016/j.cell.2024.02.004
	8XZG	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-	Gi1/β1/γ2	3.2	2024-03-20	10.1016/j.cell.2024.02.004
	8XZG (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-		3.2	2024-03-20	10.1016/j.cell.2024.02.004
	8XZF	A	Peptide	Apelin	Apelin	Homo sapiens	WN561	-	Gi1/β1/γ2	3	2024-03-20	10.1016/j.cell.2024.02.004
	8XZF (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	WN561	-		3	2024-03-20	10.1016/j.cell.2024.02.004
	7SUS	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-	-	2.7	2022-07-27	10.1038/s41594-022-00797-5
	7W0P	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-	Gi1/β1/γ2	3.16	2022-07-27	10.1038/s41594-022-00797-5
	7W0P (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-		3.16	2022-07-27	10.1038/s41594-022-00797-5
	7W0O	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-	Gi1/β1/γ2	3.78	2022-07-27	10.1038/s41594-022-00797-5
	7W0O (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-		3.78	2022-07-27	10.1038/s41594-022-00797-5
	7W0N	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-	Gi1/β1/γ2	4.21	2022-07-27	10.1038/s41594-022-00797-5
	7W0N (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-		4.21	2022-07-27	10.1038/s41594-022-00797-5
	7W0M	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-	Gi1/β1/γ2	3.71	2022-07-27	10.1038/s41594-022-00797-5
	7W0M (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-		3.71	2022-07-27	10.1038/s41594-022-00797-5
	7W0L	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-	Gi1/β1/γ2	3.57	2022-07-27	10.1038/s41594-022-00797-5
	7W0L (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-		3.57	2022-07-27	10.1038/s41594-022-00797-5
	6KNM	A	Peptide	Apelin	Apelin	Homo sapiens	JN241-9	-	-	3.2	2020-01-29	10.1126/sciadv.aax7379
	5VBL	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin mimetic peptide agonist	-	-	2.6	2017-05-31	10.1016/j.str.2017.04.008

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