Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:P3 4.465430
2L:L:P10 7.59410
3L:L:?11 8.2610
4L:L:F14 7.205400
5R:R:Y21 8.1025404
6R:R:I31 4.47667646
7R:R:F67 3.69143757
8R:R:L71 5.1675429
9R:R:D75 8.055409
10R:R:F78 7.728516
11R:R:W85 8.582516
12R:R:W95 6.70143718
13R:R:F97 7.194506
14R:R:I109 6.395416
15R:R:F110 8.024565
16R:R:Y114 6.6325466
17R:R:V117 4.095417
18R:R:F118 4.755405
19R:R:L129 5.416505
20R:R:R141 4.516507
21R:R:W154 7.08409
22R:R:L160 5.82404
23R:R:T176 5.8675403
24R:R:C181 6.1725419
25R:R:Y185 6.072505
26R:R:F210 9.425418
27R:R:F214 6.5775416
28R:R:Y221 5.328508
29R:R:I228 5.16478
30R:R:F232 4.21474
31R:R:L253 7.74407
32R:R:F257 7.908518
33R:R:W261 6.42143719
34R:R:Y264 12.09416
35R:R:H265 8.122518
36R:R:Y271 9.9404
37R:R:W279 8.364501
38R:R:F291 4.585404
39R:R:Y293 5.775445
40R:R:Y299 9.228517
41R:R:N305 6.8075429
42R:R:Y309 7.156529
43R:R:F311 5.016506
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:C1 L:L:P3 29.06733.77NoYes300
2L:L:P3 R:R:Y271 24.1035.56YesYes004
3L:L:C1 R:R:Y185 32.44085.38NoYes005
4L:L:P13 R:R:Y185 22.76424.17NoYes005
5L:L:G12 L:L:P13 31.10574.06NoNo000
6L:L:?11 L:L:G12 34.14447.84YesNo000
7L:L:?11 R:R:Y264 36.882319.34YesYes106
8R:R:F291 R:R:Y264 90.40996.19YesYes046
9R:R:F291 R:R:P292 89.43964.33YesNo044
10R:R:I31 R:R:P292 87.08163.39YesNo064
11R:R:I31 R:R:T89 53.27944.56YesNo065
12R:R:T89 R:R:Y93 50.80866.24NoNo054
13L:L:K8 R:R:Y93 41.034221.5NoNo004
14L:L:H7 L:L:K8 38.52583.93NoNo000
15L:L:?11 R:R:T295 31.2265.4YesNo005
16R:R:F291 R:R:T295 28.7743.89YesNo045
17L:L:H7 R:R:Q180 36.00986.18NoNo002
18L:L:?11 L:L:P10 13.11026.02YesYes100
19R:R:M183 R:R:Y185 24.88919.58NoYes055
20L:L:?11 R:R:I109 24.67095.23YesYes106
21L:L:?11 R:R:Y299 33.61415.37YesYes107
22R:R:M183 R:R:V164 27.11554.56NoNo054
23R:R:F110 R:R:V164 28.247513.11YesNo054
24R:R:F110 R:R:Y114 21.90311.35YesYes656
25R:R:L160 R:R:Y114 30.48144.69YesYes046
26L:L:F14 R:R:L160 38.61987.31YesYes004
27L:L:F14 R:R:L201 29.81957.31YesNo004
28R:R:D284 R:R:Y271 10.47016.9NoYes044
29R:R:M288 R:R:Y271 10.35738.38NoYes044
30R:R:I31 R:R:Y293 12.98986.04YesYes465
31R:R:I31 R:R:Y35 10.43634.84YesNo067
32R:R:L82 R:R:Y299 17.867615.24NoYes077
33R:R:L82 R:R:P83 13.94891.64NoNo079
34R:R:V38 R:R:Y299 105.05NoYes077
35R:R:F39 R:R:P83 1018.78NoNo069
36R:R:F78 R:R:I109 49.30057.54YesYes166
37R:R:F78 R:R:S302 74.76876.61YesNo068
38R:R:D75 R:R:S302 73.426111.78YesNo098
39R:R:F78 R:R:Y299 42.583714.44YesYes167
40R:R:D75 R:R:N46 1008.08YesNo099
41R:R:N46 R:R:P306 96.75826.52NoNo099
42R:R:P306 R:R:V49 86.98763.53NoNo098
43R:R:A72 R:R:V49 57.26963.39NoNo088
44R:R:A72 R:R:L50 53.934.73NoNo087
45R:R:F54 R:R:L50 47.22833.65NoNo037
46R:R:F54 R:R:R55 20.28966.41NoNo036
47R:R:R55 R:R:W51 16.867213NoNo063
48R:R:F311 R:R:V49 27.46525.24YesNo068
49R:R:F311 R:R:F316 13.79095.36YesNo069
50R:R:F54 R:R:V53 23.84363.93NoNo036
51R:R:D65 R:R:V53 17.00644.38NoNo086
52R:R:D65 R:R:R62 13.70065.96NoNo087
53R:R:D313 R:R:R62 10.26338.34NoNo087
54R:R:F110 R:R:M113 32.7686.22YesNo057
55R:R:M113 R:R:W261 33.66686.98NoYes079
56R:R:N301 R:R:W261 69.85717.91NoYes099
57R:R:N301 R:R:N305 68.24375.45NoYes099
58R:R:L71 R:R:N305 50.4258.24YesYes299
59R:R:L71 R:R:Y309 54.84773.52YesYes299
60R:R:L123 R:R:Y309 65.19743.52NoYes089
61R:R:F67 R:R:L123 62.617.31YesNo078
62R:R:F118 R:R:Y114 26.20914.13YesYes056
63R:R:F118 R:R:L153 21.97446.09YesNo056
64R:R:C119 R:R:L153 17.94284.76NoNo076
65R:R:C119 R:R:L71 19.7334.76NoYes079
66R:R:L120 R:R:N305 43.39234.12NoYes289
67R:R:L120 R:R:Y309 42.75298.21NoYes289
68R:R:D126 R:R:F67 44.03543.58NoYes087
69R:R:F78 R:R:N112 12.6896.04YesNo068
70R:R:F97 R:R:W95 14.791312.03YesYes068
71R:R:Q180 R:R:T176 33.48637.09NoYes023
72R:R:V117 R:R:W261 30.38363.68YesYes179
73R:R:F118 R:R:V117 33.03123.93YesYes057
74R:R:F257 R:R:W261 39.35697.02YesYes189
75R:R:F118 R:R:L156 18.39414.87YesNo054
76R:R:L156 R:R:L160 17.30358.3NoYes044
77R:R:F257 R:R:M217 52.414411.2YesNo088
78R:R:M217 R:R:S124 49.57136.13NoNo089
79R:R:C220 R:R:S124 57.5485.16NoNo069
80R:R:S124 R:R:Y221 34.14445.09NoYes098
81R:R:D126 R:R:R141 41.34268.34NoYes087
82R:R:L129 R:R:R141 27.7513.64YesYes057
83R:R:R127 R:R:Y221 13.96398.23NoYes098
84R:R:R127 R:R:Y309 14.96434.12NoYes099
85R:R:C220 R:R:Y128 55.5814.03NoNo068
86R:R:V132 R:R:Y128 45.633713.88NoNo078
87R:R:L129 R:R:N137 11.18845.49YesNo056
88R:R:I224 R:R:V132 39.5753.07NoNo087
89R:R:L201 R:R:W197 26.8715.69NoNo042
90R:R:V188 R:R:W197 12.015823.29NoNo022
91R:R:N175 R:R:T176 18.18732.92NoYes023
92R:R:L173 R:R:N175 15.61114.12NoNo032
93R:R:L173 R:R:Y182 13.02755.86NoNo034
94R:R:A189 R:R:W197 12.01583.89NoNo012
95R:R:H265 R:R:Y264 70.778510.89YesYes186
96R:R:F210 R:R:H265 17.954114.71YesYes188
97R:R:L253 R:R:Y221 23.86244.69YesYes078
98R:R:L253 R:R:Y309 33.542716.41YesYes079
99R:R:I224 R:R:I228 35.49832.94NoYes088
100R:R:F232 R:R:I228 27.44266.28YesYes748
101R:R:F232 R:R:R243 23.45243.21YesNo046
102R:R:K234 R:R:R243 19.25548.66NoNo036
103R:R:K234 R:R:L240 12.90331.41NoNo034
104R:R:I237 R:R:L240 10.7711.43NoNo034
105R:R:I249 R:R:L253 14.30245.71NoYes077
106R:R:L253 R:R:L308 14.29114.15YesNo078
107R:R:F291 R:R:V267 28.41673.93YesNo044
108R:R:L287 R:R:V267 23.3174.47NoNo044
109R:R:F283 R:R:L287 20.75599.74NoNo034
110R:R:F283 R:R:W279 18.187328.06NoYes031
111L:L:P10 R:R:W85 35.107213.51YesYes106
112R:R:H265 R:R:W261 61.03054.23YesYes189
113R:R:F78 R:R:W261 59.58264.01YesYes169
114R:R:D75 R:R:N305 66.28439.42YesYes099
115R:R:W85 R:R:W95 23.24938.43YesYes168
116R:R:F210 R:R:F257 13.69696.43YesYes188
117L:L:P10 R:R:I109 25.49836.77YesYes106
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:C1 R:R:Y185 5.38 3 No Yes 0 5 0 1
L:L:P3 R:R:Y271 5.56 3 Yes Yes 0 4 0 1
L:L:L5 R:R:Y271 18.76 0 No Yes 0 4 0 1
L:L:H7 R:R:Q180 6.18 0 No No 0 2 0 1
L:L:K8 R:R:Y93 21.5 0 No No 0 4 0 1
L:L:P10 R:R:W85 13.51 1 Yes Yes 0 6 0 1
L:L:P10 R:R:I109 6.77 1 Yes Yes 0 6 0 1
L:L:?11 R:R:I109 5.23 1 Yes Yes 0 6 0 1
L:L:?11 R:R:Y264 19.34 1 Yes Yes 0 6 0 1
L:L:?11 R:R:T295 5.4 1 Yes No 0 5 0 1
L:L:?11 R:R:Y299 5.37 1 Yes Yes 0 7 0 1
L:L:P13 R:R:Y185 4.17 0 No Yes 0 5 0 1
L:L:F14 R:R:L160 7.31 0 Yes Yes 0 4 0 1
L:L:F14 R:R:P163 11.56 0 Yes No 0 8 0 1
L:L:F14 R:R:L201 7.31 0 Yes No 0 4 0 1
R:R:D23 R:R:Y93 4.6 0 No No 5 4 2 1
R:R:V38 R:R:Y299 5.05 0 No Yes 7 7 2 1
R:R:F78 R:R:I109 7.54 1 Yes Yes 6 6 2 1
R:R:F78 R:R:Y299 14.44 1 Yes Yes 6 7 2 1
R:R:L82 R:R:Y299 15.24 0 No Yes 7 7 2 1
R:R:W85 R:R:Y88 5.79 1 Yes No 6 5 1 2
R:R:W85 R:R:W95 8.43 1 Yes Yes 6 8 1 2
R:R:S105 R:R:W85 8.65 0 No Yes 5 6 2 1
R:R:C181 R:R:W85 6.53 1 Yes Yes 9 6 2 1
R:R:W95 R:R:Y88 9.65 1 Yes No 8 5 2 2
R:R:T89 R:R:Y93 6.24 0 No No 5 4 2 1
R:R:C181 R:R:W95 3.92 1 Yes Yes 9 8 2 2
R:R:I109 R:R:Y299 6.04 1 Yes Yes 6 7 1 1
R:R:L160 R:R:Y114 4.69 0 Yes Yes 4 6 1 2
R:R:L156 R:R:L160 8.3 0 No Yes 4 4 2 1
R:R:Q180 R:R:T176 7.09 0 No Yes 2 3 1 2
R:R:M183 R:R:Y185 9.58 0 No Yes 5 5 2 1
R:R:E198 R:R:Y185 7.86 0 No Yes 4 5 2 1
R:R:L201 R:R:W197 5.69 0 No No 4 2 1 2
R:R:H265 R:R:Y264 10.89 1 Yes Yes 8 6 2 1
R:R:K268 R:R:Y264 11.94 1 No Yes 5 6 2 1
R:R:F291 R:R:Y264 6.19 0 Yes Yes 4 6 2 1
R:R:H265 R:R:K268 3.93 1 Yes No 8 5 2 2
R:R:D284 R:R:Y271 6.9 0 No Yes 4 4 2 1
R:R:M288 R:R:Y271 8.38 0 No Yes 4 4 2 1
R:R:F291 R:R:T295 3.89 0 Yes No 4 5 2 1
R:R:G202 R:R:M272 3.49 0 No No 5 5 1 2
R:R:E194 R:R:Y185 3.37 0 No Yes 6 5 2 1
R:R:L160 R:R:V208 2.98 0 Yes No 4 5 1 2
L:L:F14 R:R:S204 2.64 0 Yes No 0 4 0 1
L:L:P13 R:R:G202 2.03 0 No No 0 5 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8XZF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.51
Number of Linked Nodes 296
Number of Links 324
Number of Hubs 43
Number of Links mediated by Hubs 161
Number of Communities 7
Number of Nodes involved in Communities 38
Number of Links involved in Communities 50
Path Summary
Number Of Nodes in MetaPath 118
Number Of Links MetaPath 117
Number of Shortest Paths 94417
Length Of Smallest Path 3
Average Path Length 14.3986
Length of Longest Path 33
Minimum Path Strength 1.355
Average Path Strength 6.63104
Maximum Path Strength 20.88
Minimum Path Correlation 0.7
Average Path Correlation 0.930525
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.44828
Average % Of Corr. Nodes 50.4253
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.6368
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases   • G protein-coupled receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeMED
PDB ResiduesL:L:?11
Environment DetailsOpen EMBL-EBI Page
CodeMED
NameD-Methionine
SynonymsD-Methionine
Identifier
FormulaC5 H11 N O2 S
Molecular Weight149.211
SMILES
PubChem84815
Formal Charge0
Total Atoms20
Total Chiral Atoms1
Total Bonds19
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP35414
Sequence
>8XZF_nogp_Chain_R
ECEYTDWKS SGALIPAIY MLVFLLGTT GNGLVLWTV FRSRSADIF 
IASLAVADL TFVVTLPLW ATYTYRDYD WPFGTFFCK LSSYLIFVN 
MYASVFCLT GLSFDRYLA IVRPVANAR LRLRVSGAV ATAVLWVLA 
ALLAMPVMV LRTTGDLEN TTKVQCYMD YSMVATVSS EWAWEVGLG 
VSSTTVGFV VPFTIMLTC YFFIAQTIA GHFRKERIE GLRKRRRLL 
SIIVVLVVT FALCWMPYH LVKTLYMLG SLLHWPCDF DLFLMNIFP 
YCTCISYVN SCLNPFLYA FFDPRFRQA CTSMLC


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XZFAPeptideApelinApelinHomo sapiensWN561-Gi1/β1/γ232024-03-20doi.org/10.1016/j.cell.2024.02.004
8XZF (No Gprot) APeptideApelinApelinHomo sapiensWN561-32024-03-20doi.org/10.1016/j.cell.2024.02.004
8XZGAPeptideApelinApelinHomo sapiensApelin-13-Gi1/β1/γ23.22024-03-20doi.org/10.1016/j.cell.2024.02.004
8XZG (No Gprot) APeptideApelinApelinHomo sapiensApelin-13-3.22024-03-20doi.org/10.1016/j.cell.2024.02.004
8XZHAPeptideApelinApelinHomo sapiensMM07-Gi1/β1/γ22.062024-03-20doi.org/10.1016/j.cell.2024.02.004
8XZH (No Gprot) APeptideApelinApelinHomo sapiensMM07-2.062024-03-20doi.org/10.1016/j.cell.2024.02.004
8XZJAPeptideApelinApelinHomo sapiensWN353-Gi1/β1/γ232024-03-20doi.org/10.1016/j.cell.2024.02.004
8XZJ (No Gprot) APeptideApelinApelinHomo sapiensWN353-32024-03-20doi.org/10.1016/j.cell.2024.02.004
5VBLAPeptideApelinApelinHomo sapiensApelin mimetic peptide agonist--2.62017-05-31doi.org/10.1016/j.str.2017.04.008
8Z74APeptideApelinApelinHomo sapiensAgonistic antibody--3.012025-01-22doi.org/10.1038/s41467-024-55555-6
8Z7JAPeptideApelinApelinHomo sapiensAgonistic antibody-Gi1/β1/γ23.122025-01-22doi.org/10.1038/s41467-024-55555-6
8Z7J (No Gprot) APeptideApelinApelinHomo sapiensAgonistic antibody-3.122025-01-22doi.org/10.1038/s41467-024-55555-6
7SUSAPeptideApelinApelinHomo sapiensPubChem 122701908--2.72022-07-27doi.org/10.1038/s41594-022-00797-5
7W0LAPeptideApelinApelinHomo sapiensPubChem 122701908-Gi1/β1/γ23.572022-07-27doi.org/10.1038/s41594-022-00797-5
7W0L (No Gprot) APeptideApelinApelinHomo sapiensPubChem 122701908-3.572022-07-27doi.org/10.1038/s41594-022-00797-5
7W0MAPeptideApelinApelinHomo sapiensPubChem 122701908-Gi1/β1/γ23.712022-07-27doi.org/10.1038/s41594-022-00797-5
7W0M (No Gprot) APeptideApelinApelinHomo sapiensPubChem 122701908-3.712022-07-27doi.org/10.1038/s41594-022-00797-5
7W0NAPeptideApelinApelinHomo sapiensElabela-Gi1/β1/γ24.212022-07-27doi.org/10.1038/s41594-022-00797-5
7W0N (No Gprot) APeptideApelinApelinHomo sapiensElabela-4.212022-07-27doi.org/10.1038/s41594-022-00797-5
7W0OAPeptideApelinApelinHomo sapiensElabela-Gi1/β1/γ23.782022-07-27doi.org/10.1038/s41594-022-00797-5
7W0O (No Gprot) APeptideApelinApelinHomo sapiensElabela-3.782022-07-27doi.org/10.1038/s41594-022-00797-5
7W0PAPeptideApelinApelinHomo sapiensElabela-Gi1/β1/γ23.162022-07-27doi.org/10.1038/s41594-022-00797-5
7W0P (No Gprot) APeptideApelinApelinHomo sapiensElabela-3.162022-07-27doi.org/10.1038/s41594-022-00797-5
6KNMAPeptideApelinApelinHomo sapiensJN241-9--3.22020-01-29doi.org/10.1126/sciadv.aax7379
8XZIAPeptideApelinApelinHomo sapiensCMF-019-Gi1/β1/γ22.72024-03-20doi.org/10.1016/j.cell.2024.02.004
8XZI (No Gprot) APeptideApelinApelinHomo sapiensCMF-019-2.72024-03-20doi.org/10.1016/j.cell.2024.02.004
8S4DAPeptideApelinApelinHomo sapiensCMF-019--2.582024-12-04doi.org/10.1038/s41467-024-55381-w
8XQEAPeptideApelinApelinHomo sapiensApelin-13-Gi1/β1/γ23.482025-01-22doi.org/10.1038/s41467-024-55555-6
8XQE (No Gprot) APeptideApelinApelinHomo sapiensApelin-13-3.482025-01-22doi.org/10.1038/s41467-024-55555-6
8XQFAPeptideApelinApelinHomo sapiensApelin-13-Gi1/β1/γ23.132025-01-22doi.org/10.1038/s41467-024-55555-6
8XQF (No Gprot) APeptideApelinApelinHomo sapiensApelin-13-3.132025-01-22doi.org/10.1038/s41467-024-55555-6
8XQIAPeptideApelinApelinHomo sapiens---3.252025-01-22doi.org/10.1038/s41467-024-55555-6
8XQJAPeptideApelinApelinHomo sapiensJN241--2.952025-01-22doi.org/10.1038/s41467-024-55555-6
9JH3APeptideApelinApelinHomo sapiensCMF-019-Gi1/β1/γ22.932025-04-23doi.org/10.1073/pnas.2423432122
9JH3 (No Gprot) APeptideApelinApelinHomo sapiensCMF-019-2.932025-04-23doi.org/10.1073/pnas.2423432122




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8XZF_nogp.zip



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You can also  read or  download a guide explaining the meaning of all files and numerical data.