psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:L40	L:L:R42	12.15	No	No	0	0	0
2	L:L:Q41	L:L:R43	4.67	No	No	0	0	0
3	L:L:M45	L:L:R42	2.48	Yes	No	0	0	0
4	L:L:C44	L:L:L47	3.17	No	No	0	0	0
5	L:L:C44	R:R:Y271	2.69	No	No	0	0	4
6	L:L:M45	L:L:P46	6.71	Yes	No	2	0	0
7	L:L:M45	L:L:R50	4.96	Yes	No	2	0	0
8	L:L:M45	R:R:Y93	2.39	Yes	No	0	0	4
9	L:L:P46	L:L:R50	2.88	No	No	2	0	0
10	L:L:P46	R:R:M288	3.35	No	No	2	0	4
11	L:L:L47	R:R:Y185	5.86	No	No	0	0	5
12	L:L:H48	L:L:P54	9.15	No	No	0	0	0
13	L:L:H48	R:R:R168	19.18	No	Yes	5	0	5
14	L:L:H48	R:R:M183	9.19	No	Yes	5	0	5
15	L:L:S49	R:R:L173	3	No	Yes	3	0	3
16	L:L:S49	R:R:Q180	5.78	No	No	3	0	2
17	L:L:V51	R:R:W85	3.68	No	Yes	0	0	6
18	L:L:P52	R:R:W85	2.7	No	Yes	0	0	6
19	L:L:F53	R:R:W85	13.03	No	Yes	0	0	6
20	L:L:F53	R:R:I109	8.79	No	No	0	0	6
21	L:L:P54	R:R:F110	4.33	No	No	0	0	5
22	R:R:S26	R:R:S27	3.26	No	No	0	3	3
23	R:R:N289	R:R:S26	7.45	No	No	0	2	3
24	R:R:G28	R:R:S27	3.71	No	No	0	3	3
25	R:R:L30	R:R:Y90	2.34	No	Yes	0	5	3
26	R:R:I31	R:R:P32	5.08	No	Yes	1	6	5
27	R:R:I31	R:R:Y35	12.09	No	Yes	1	6	7
28	R:R:P32	R:R:Y35	2.78	Yes	Yes	1	5	7
29	R:R:M36	R:R:P32	3.35	No	Yes	0	3	5
30	R:R:P32	R:R:T89	3.5	Yes	No	1	5	5
31	R:R:P32	R:R:Y90	9.74	Yes	Yes	1	5	3
32	R:R:I34	R:R:Y35	4.84	No	Yes	0	5	7
33	R:R:F39	R:R:Y35	3.09	Yes	Yes	1	6	7
34	R:R:T295	R:R:Y35	7.49	No	Yes	0	5	7
35	R:R:F39	R:R:V79	5.24	Yes	No	0	6	6
36	R:R:F39	R:R:L82	13.4	Yes	Yes	1	6	7
37	R:R:F39	R:R:Y299	6.19	Yes	Yes	1	6	7
38	R:R:N46	R:R:T43	2.92	Yes	No	0	9	5
39	R:R:G45	R:R:T44	3.64	No	No	0	8	4
40	R:R:G47	R:R:N46	3.39	No	Yes	0	3	9
41	R:R:D75	R:R:N46	9.42	Yes	Yes	0	9	9
42	R:R:L76	R:R:N46	8.24	No	Yes	0	7	9
43	R:R:G47	R:R:L50	3.42	No	No	0	3	7
44	R:R:A72	R:R:V49	3.39	No	No	0	8	8
45	R:R:F54	R:R:L50	3.65	No	No	0	3	7
46	R:R:L50	R:R:L76	4.15	No	No	0	7	7
47	R:R:R55	R:R:W51	13.99	No	No	0	6	3
48	R:R:R317	R:R:T52	5.17	Yes	No	0	8	7
49	R:R:F54	R:R:V53	3.93	No	No	0	3	6
50	R:R:R317	R:R:V53	6.54	Yes	No	0	8	6
51	R:R:R61	R:R:S56	2.64	No	No	0	6	5
52	R:R:K60	R:R:S57	3.06	No	No	0	6	6
53	R:R:R61	R:R:S57	5.27	No	No	0	6	6
54	R:R:K60	R:R:R58	3.71	No	No	0	6	6
55	R:R:D65	R:R:R61	11.91	No	No	0	8	6
56	R:R:D65	R:R:I68	4.2	No	No	9	8	8
57	R:R:D65	R:R:R317	9.53	No	Yes	9	8	8
58	R:R:F67	R:R:I66	3.77	No	No	0	7	5
59	R:R:D126	R:R:F67	2.39	No	No	0	8	7
60	R:R:F67	R:R:T150	5.19	No	No	0	7	6
61	R:R:I68	R:R:R317	11.27	No	Yes	9	8	8
62	R:R:C119	R:R:L71	3.17	No	No	0	7	9
63	R:R:L71	R:R:N305	4.12	No	No	0	9	9
64	R:R:L71	R:R:Y309	2.34	No	Yes	0	9	9
65	R:R:D75	R:R:V79	2.92	Yes	No	0	9	6
66	R:R:D75	R:R:S302	4.42	Yes	No	0	9	8
67	R:R:D75	R:R:P306	3.22	Yes	No	0	9	9
68	R:R:L76	R:R:V80	2.98	No	No	0	7	4
69	R:R:T77	R:R:V80	3.17	No	No	0	7	4
70	R:R:F78	R:R:I109	5.02	Yes	No	0	6	6
71	R:R:F78	R:R:N112	12.08	Yes	No	0	6	8
72	R:R:F78	R:R:Y299	7.22	Yes	Yes	0	6	7
73	R:R:F78	R:R:S302	3.96	Yes	No	0	6	8
74	R:R:I109	R:R:T81	3.04	No	No	0	6	7
75	R:R:L82	R:R:W85	2.28	Yes	Yes	0	7	6
76	R:R:L82	R:R:Y299	4.69	Yes	Yes	1	7	7
77	R:R:L84	R:R:W95	3.42	No	Yes	6	6	8
78	R:R:F97	R:R:L84	7.31	Yes	No	6	6	6
79	R:R:F101	R:R:L84	2.44	No	No	6	5	6
80	R:R:W85	R:R:W95	2.81	Yes	Yes	0	6	8
81	R:R:T87	R:R:Y90	6.24	No	Yes	0	4	3
82	R:R:R91	R:R:Y88	2.06	No	No	0	3	5
83	R:R:D92	R:R:Y88	6.9	No	No	0	6	5
84	R:R:T89	R:R:Y90	3.75	No	Yes	1	5	3
85	R:R:D94	R:R:R91	8.34	No	No	0	4	3
86	R:R:P96	R:R:R91	15.85	No	No	0	4	3
87	R:R:D92	R:R:Y93	27.59	No	No	0	6	4
88	R:R:K178	R:R:Y93	2.39	No	No	0	2	4
89	R:R:D94	R:R:V179	2.92	No	No	0	4	5
90	R:R:P96	R:R:W95	8.11	No	Yes	6	4	8
91	R:R:F97	R:R:W95	3.01	Yes	Yes	6	6	8
92	R:R:G98	R:R:W95	2.81	No	Yes	0	8	8
93	R:R:F101	R:R:W95	6.01	No	Yes	6	5	8
94	R:R:C102	R:R:W95	11.75	No	Yes	0	9	8
95	R:R:F97	R:R:P96	8.67	Yes	No	6	6	4
96	R:R:F101	R:R:F97	17.15	No	Yes	6	5	6
97	R:R:K103	R:R:T99	3	No	No	0	7	3
98	R:R:T170	R:R:T99	10.99	No	No	0	5	3
99	R:R:F100	R:R:L104	2.44	No	No	0	1	5
100	R:R:C102	R:R:C181	5.46	No	No	0	9	9
101	R:R:K103	R:R:V166	3.04	No	No	0	7	4
102	R:R:R168	R:R:S106	9.22	Yes	No	0	5	5
103	R:R:A161	R:R:Y107	2.67	No	Yes	0	7	5
104	R:R:M162	R:R:Y107	3.59	Yes	Yes	10	4	5
105	R:R:M165	R:R:Y107	4.79	No	Yes	10	5	5
106	R:R:F110	R:R:Y114	8.25	No	Yes	0	5	6
107	R:R:N112	R:R:V111	2.96	No	No	0	8	4
108	R:R:M113	R:R:Y114	9.58	No	Yes	0	7	6
109	R:R:M113	R:R:W261	2.33	No	Yes	0	7	9
110	R:R:H265	R:R:M113	2.63	Yes	No	0	8	7
111	R:R:F118	R:R:Y114	2.06	Yes	Yes	4	5	6
112	R:R:L160	R:R:Y114	10.55	No	Yes	4	4	6
113	R:R:S205	R:R:Y114	3.82	No	Yes	0	4	6
114	R:R:S116	R:R:W261	3.71	No	Yes	0	9	9
115	R:R:F118	R:R:V117	2.62	Yes	No	4	5	7
116	R:R:G209	R:R:V117	3.68	No	No	4	5	7
117	R:R:P213	R:R:V117	3.53	No	No	4	9	7
118	R:R:F118	R:R:L153	6.09	Yes	No	0	5	6
119	R:R:A157	R:R:F118	2.77	No	Yes	0	7	5
120	R:R:F118	R:R:L160	2.44	Yes	No	4	5	4
121	R:R:F257	R:R:L120	6.09	Yes	No	0	8	8
122	R:R:L120	R:R:Y309	4.69	No	Yes	0	8	9
123	R:R:I216	R:R:T121	4.56	No	No	0	6	7
124	R:R:M217	R:R:T121	6.02	No	No	0	8	7
125	R:R:L123	R:R:Y309	4.69	No	Yes	0	8	9
126	R:R:R127	R:R:S124	3.95	No	Yes	8	9	9
127	R:R:M217	R:R:S124	3.07	No	Yes	0	8	9
128	R:R:C220	R:R:S124	5.16	No	Yes	8	6	9
129	R:R:S124	R:R:Y221	3.82	Yes	Yes	8	9	8
130	R:R:F125	R:R:Y128	3.09	No	Yes	0	6	8
131	R:R:D126	R:R:R127	3.57	No	No	0	8	9
132	R:R:R127	R:R:Y221	6.17	No	Yes	8	9	8
133	R:R:V132	R:R:Y128	2.52	No	Yes	0	7	8
134	R:R:C220	R:R:Y128	5.38	No	Yes	0	6	8
135	R:R:F223	R:R:Y128	8.25	No	Yes	0	5	8
136	R:R:L129	R:R:N137	5.49	No	No	0	5	6
137	R:R:I131	R:R:I224	2.94	No	No	0	8	8
138	R:R:N137	R:R:V132	2.96	No	No	0	6	7
139	R:R:A136	R:R:R133	2.77	No	No	0	4	6
140	R:R:N137	R:R:R133	3.62	No	No	0	6	6
141	R:R:A138	R:R:R141	5.53	No	No	0	5	7
142	R:R:L140	R:R:R143	7.29	No	No	0	4	3
143	R:R:L140	R:R:V144	2.98	No	No	0	4	4
144	R:R:L156	R:R:V152	2.98	No	No	0	4	2
145	R:R:V155	R:R:W154	4.9	No	No	0	4	9
146	R:R:M162	R:R:M165	7.22	Yes	No	10	4	5
147	R:R:L167	R:R:V164	4.47	No	No	0	5	4
148	R:R:R168	R:R:V164	3.92	Yes	No	0	5	4
149	R:R:L167	R:R:M183	7.07	No	Yes	0	5	5
150	R:R:M183	R:R:R168	2.48	Yes	Yes	5	5	5
151	R:R:T169	R:R:Y182	3.75	No	Yes	3	4	4
152	R:R:D184	R:R:T169	14.45	No	No	3	3	4
153	R:R:C181	R:R:T170	5.07	No	No	0	9	5
154	R:R:G171	R:R:Y182	4.35	No	Yes	0	1	4
155	R:R:D172	R:R:T177	8.67	No	No	0	1	5
156	R:R:D172	R:R:V179	4.38	No	No	0	1	5
157	R:R:E174	R:R:L173	3.98	No	Yes	0	2	3
158	R:R:L173	R:R:T176	4.42	Yes	No	0	3	3
159	R:R:L173	R:R:Q180	14.64	Yes	No	3	3	2
160	R:R:E174	R:R:N175	6.57	No	No	0	2	2
161	R:R:N175	R:R:T176	5.85	No	No	0	2	3
162	R:R:K178	R:R:T176	7.51	No	No	0	2	3
163	R:R:Q180	R:R:Y182	7.89	No	Yes	3	2	4
164	R:R:D184	R:R:Y182	4.6	No	Yes	3	3	4
165	R:R:M183	R:R:Y185	4.79	Yes	No	0	5	5
166	R:R:E198	R:R:M183	4.06	Yes	Yes	5	4	5
167	R:R:D184	R:R:S186	7.36	No	No	0	3	5
168	R:R:E194	R:R:Y185	4.49	No	No	0	6	5
169	R:R:E194	R:R:M187	8.12	No	No	5	6	2
170	R:R:E198	R:R:M187	2.71	Yes	No	5	4	2
171	R:R:A189	R:R:S193	3.42	No	No	0	1	4
172	R:R:S193	R:R:T190	4.8	No	No	0	4	1
173	R:R:S193	R:R:W197	2.47	No	No	0	4	2
174	R:R:E194	R:R:E198	7.61	No	Yes	5	6	4
175	R:R:V199	R:R:W195	7.36	No	No	0	3	2
176	R:R:K268	R:R:S205	3.06	Yes	No	0	5	4
177	R:R:F210	R:R:T206	2.59	Yes	Yes	7	8	5
178	R:R:H265	R:R:T206	9.58	Yes	Yes	7	8	5
179	R:R:K268	R:R:T206	6.01	Yes	Yes	7	5	5
180	R:R:T206	R:R:T269	3.14	Yes	No	0	5	6
181	R:R:G209	R:R:V208	3.68	No	No	0	5	5
182	R:R:G209	R:R:P213	4.06	No	No	4	5	9
183	R:R:F210	R:R:W261	6.01	Yes	Yes	0	8	9
184	R:R:F210	R:R:M262	8.71	Yes	No	0	8	5
185	R:R:F210	R:R:H265	14.71	Yes	Yes	7	8	8
186	R:R:P213	R:R:V212	7.07	No	No	0	9	6
187	R:R:I216	R:R:V212	3.07	No	No	0	6	6
188	R:R:F214	R:R:L218	2.44	No	No	0	6	4
189	R:R:A258	R:R:F214	2.77	No	No	0	5	6
190	R:R:I216	R:R:T215	3.04	No	No	0	6	2
191	R:R:F257	R:R:M217	3.73	Yes	No	0	8	8
192	R:R:F223	R:R:T219	9.08	No	No	0	5	4
193	R:R:C220	R:R:Y221	4.03	No	Yes	8	6	8
194	R:R:I250	R:R:Y221	4.84	No	Yes	0	7	8
195	R:R:L253	R:R:Y221	7.03	Yes	Yes	0	7	8
196	R:R:F222	R:R:F223	2.14	No	No	0	3	5
197	R:R:F222	R:R:Q226	12.88	No	No	0	3	3
198	R:R:I224	R:R:T227	4.56	No	No	0	8	4
199	R:R:F232	R:R:I228	3.77	No	No	0	4	8
200	R:R:I228	R:R:L246	5.71	No	No	0	8	7
201	R:R:F232	R:R:R243	2.14	No	Yes	0	4	6
202	R:R:K234	R:R:R236	4.95	No	No	0	3	2
203	R:R:E235	R:R:R243	16.28	No	Yes	0	4	6
204	R:R:E238	R:R:I237	9.56	No	No	0	4	3
205	R:R:L240	R:R:R243	4.86	No	Yes	0	4	6
206	R:R:K242	R:R:L246	2.82	No	No	0	5	7
207	R:R:L247	R:R:R243	3.64	No	Yes	0	6	6
208	R:R:L247	R:R:R244	3.64	No	No	0	6	5
209	R:R:F312	R:R:R245	9.62	No	No	0	6	7
210	R:R:I250	R:R:L246	2.85	No	No	0	7	7
211	R:R:I249	R:R:L253	2.85	No	Yes	0	7	7
212	R:R:F312	R:R:I249	10.05	No	No	0	6	7
213	R:R:L253	R:R:Y309	7.03	Yes	Yes	0	7	9
214	R:R:L259	R:R:V255	2.98	No	No	0	5	4
215	R:R:L304	R:R:T256	5.9	No	No	11	6	6
216	R:R:L308	R:R:T256	4.42	Yes	No	11	8	6
217	R:R:F257	R:R:W261	9.02	Yes	Yes	0	8	9
218	R:R:C260	R:R:N301	6.3	No	No	0	7	9
219	R:R:N301	R:R:W261	12.43	No	Yes	0	9	9
220	R:R:L266	R:R:M262	4.24	No	No	0	6	5
221	R:R:I297	R:R:P263	5.08	No	No	0	6	9
222	R:R:K268	R:R:Y264	7.17	Yes	No	0	5	6
223	R:R:F291	R:R:Y264	5.16	No	No	0	4	6
224	R:R:C294	R:R:Y264	6.72	No	No	0	6	6
225	R:R:H265	R:R:K268	10.48	Yes	Yes	7	8	5
226	R:R:L287	R:R:V267	2.98	Yes	No	0	4	4
227	R:R:F291	R:R:V267	3.93	No	No	0	4	4
228	R:R:C294	R:R:V267	3.42	No	No	0	6	4
229	R:R:K268	R:R:M272	2.88	Yes	No	0	5	5
230	R:R:L287	R:R:Y271	3.52	Yes	No	2	4	4
231	R:R:M288	R:R:Y271	2.39	No	No	2	4	4
232	R:R:G274	R:R:W279	8.44	No	Yes	0	3	1
233	R:R:H278	R:R:L277	11.57	No	No	0	2	1
234	R:R:H278	R:R:P280	6.1	No	No	0	2	4
235	R:R:F283	R:R:W279	10.02	No	Yes	0	3	1
236	R:R:D284	R:R:W279	8.93	No	Yes	0	4	1
237	R:R:L287	R:R:W279	10.25	Yes	Yes	0	4	1
238	R:R:F283	R:R:P280	7.22	No	No	0	3	4
239	R:R:C281	R:R:D284	4.67	No	No	0	8	4
240	R:R:D282	R:R:F286	11.94	No	No	0	2	1
241	R:R:F283	R:R:F286	4.29	No	No	0	3	1
242	R:R:L285	R:R:N289	2.75	No	No	0	3	2
243	R:R:L287	R:R:M288	4.24	Yes	No	2	4	4
244	R:R:I290	R:R:N289	5.66	No	No	0	4	2
245	R:R:I290	R:R:Y293	4.84	No	No	0	4	5
246	R:R:T295	R:R:Y299	2.5	No	Yes	0	5	7
247	R:R:S298	R:R:Y299	3.82	No	Yes	0	7	7
248	R:R:N301	R:R:V300	2.96	No	No	0	9	5
249	R:R:C303	R:R:V300	3.42	No	No	0	7	5
250	R:R:L304	R:R:N305	2.75	No	No	0	6	9
251	R:R:L304	R:R:L308	2.77	No	Yes	11	6	8
252	R:R:L308	R:R:Y309	4.69	Yes	Yes	0	8	9
253	R:R:F311	R:R:F316	6.43	No	No	0	6	9
254	R:R:P314	R:R:R315	8.65	No	No	0	5	7
255	R:R:A147	R:R:G146	1.95	No	No	0	4	7
256	R:R:A229	R:R:G230	1.95	No	No	0	4	4
257	R:R:A86	R:R:P32	1.87	No	Yes	0	6	5
258	R:R:G146	R:R:S145	1.86	No	No	0	7	4
259	R:R:G202	R:R:S205	1.86	No	No	0	5	4
260	R:R:G200	R:R:V199	1.84	No	No	0	2	3
261	R:R:P306	R:R:V49	1.77	No	No	0	9	8
262	R:R:C102	R:R:S105	1.72	No	No	0	9	5
263	R:R:G42	R:R:L41	1.71	No	No	0	8	5
264	R:R:G122	R:R:L153	1.71	No	No	0	6	6
265	R:R:G202	R:R:L201	1.71	No	No	0	5	4
266	R:R:G274	R:R:L273	1.71	No	No	0	3	4
267	R:R:A310	R:R:V49	1.7	No	No	0	6	8
268	R:R:A149	R:R:V144	1.7	No	No	0	5	4
269	R:R:I31	R:R:P292	1.69	No	No	0	6	4
270	R:R:C296	R:R:T295	1.69	No	No	0	5	5
271	R:R:M162	R:R:P163	1.68	Yes	No	0	4	8
272	R:R:M262	R:R:P263	1.68	No	No	0	5	9
273	R:R:L82	R:R:P83	1.64	Yes	No	0	7	9
274	R:R:A130	R:R:I131	1.62	No	No	0	8	8
275	R:R:A158	R:R:M162	1.61	No	Yes	0	4	4
276	R:R:D313	R:R:P314	1.61	No	No	0	8	5
277	R:R:S192	R:R:T190	1.6	No	No	0	2	1
278	R:R:V211	R:R:V212	1.6	No	No	0	4	6
279	R:R:T207	R:R:V203	1.59	No	No	0	3	4
280	R:R:T207	R:R:V211	1.59	No	No	0	3	4
281	R:R:A29	R:R:L30	1.58	No	No	0	3	5
282	R:R:A64	R:R:L123	1.58	No	No	0	8	8
283	R:R:A258	R:R:L259	1.58	No	No	0	5	5
284	R:R:A74	R:R:N112	1.56	No	No	0	8	8
285	R:R:I224	R:R:V132	1.54	No	No	0	8	7
286	R:R:M272	R:R:S275	1.53	No	No	0	5	4
287	R:R:G239	R:R:R236	1.5	No	No	0	4	2
288	R:R:L276	R:R:S275	1.5	No	No	0	1	4
289	R:R:L37	R:R:V38	1.49	No	No	0	5	7
290	R:R:L253	R:R:V252	1.49	Yes	No	0	7	5
291	R:R:L308	R:R:V252	1.49	Yes	No	0	8	5
292	R:R:L40	R:R:T44	1.47	No	No	0	5	4
293	R:R:L41	R:R:T44	1.47	No	No	0	5	4
294	R:R:D126	R:R:S63	1.47	No	No	0	8	6
295	R:R:L108	R:R:T77	1.47	No	No	0	4	7
296	R:R:P134	R:R:R133	1.44	No	No	0	8	6
297	R:R:P292	R:R:Y293	1.39	No	No	0	4	5
298	R:R:L37	R:R:L41	1.38	No	No	0	5	5
299	R:R:L156	R:R:L159	1.38	No	No	0	4	4
300	R:R:L270	R:R:L273	1.38	No	No	0	5	4
301	R:R:L270	R:R:L287	1.38	No	Yes	0	5	4
302	R:R:R141	R:R:S145	1.32	No	No	0	7	4
303	R:R:F125	R:R:V144	1.31	No	No	0	6	4
304	R:R:V111	R:R:Y107	1.26	No	Yes	0	4	5
305	R:R:V254	R:R:Y221	1.26	No	Yes	0	7	8
306	R:R:K234	R:R:R233	1.24	No	No	0	3	4
307	R:R:F118	R:R:L156	1.22	Yes	No	0	5	4
308	R:R:T52	R:R:W51	1.21	No	No	0	7	3
309	R:R:L142	R:R:R143	1.21	No	No	0	6	3
310	R:R:L240	R:R:R241	1.21	No	No	0	4	4
311	R:R:F232	R:R:H231	1.13	No	No	0	4	5
312	R:R:E198	R:R:W195	1.09	Yes	No	0	4	2
313	R:R:F214	R:R:F257	1.07	No	Yes	0	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:M45	4.135	4	2	0
2	R:R:P32	4.38667	6	1	5
3	R:R:Y35	6.058	5	1	7
4	R:R:F39	6.98	4	1	6
5	R:R:N46	5.9925	4	0	9
6	R:R:D75	4.995	4	0	9
7	R:R:F78	7.07	4	0	6
8	R:R:L82	5.5025	4	1	7
9	R:R:W85	4.9	5	0	6
10	R:R:Y90	5.5175	4	1	3
11	R:R:W95	5.41714	7	6	8
12	R:R:F97	9.035	4	6	6
13	R:R:Y107	3.0775	4	10	5
14	R:R:Y114	6.852	5	4	6
15	R:R:F118	2.86667	6	4	5
16	R:R:S124	4	4	8	9
17	R:R:Y128	4.81	4	0	8
18	R:R:M162	3.525	4	10	4
19	R:R:R168	8.7	4	5	5
20	R:R:L173	6.51	4	3	3
21	R:R:Y182	5.1475	4	3	4
22	R:R:M183	5.518	5	5	5
23	R:R:E198	3.8675	4	5	4
24	R:R:T206	5.33	4	7	5
25	R:R:F210	8.005	4	7	8
26	R:R:Y221	4.525	6	8	8
27	R:R:R243	6.73	4	0	6
28	R:R:L253	4.6	4	0	7
29	R:R:F257	4.9775	4	0	8
30	R:R:W261	6.7	5	0	9
31	R:R:H265	9.35	4	7	8
32	R:R:K268	5.92	5	7	5
33	R:R:W279	9.41	4	0	1
34	R:R:L287	4.474	5	2	4
35	R:R:Y299	4.884	5	1	7
36	R:R:L308	3.3425	4	11	8
37	R:R:Y309	4.688	5	0	9
38	R:R:R317	8.1275	4	9	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:P46	R:R:M288	95.0224	3.35	No	No	2	0	4
2	L:L:M45	L:L:P46	93.8467	6.71	Yes	No	2	0	0
3	L:L:M45	R:R:Y93	92.3743	2.39	Yes	No	0	0	4
4	R:R:K178	R:R:Y93	11.0613	2.39	No	No	0	2	4
5	R:R:K178	R:R:T176	10.225	7.51	No	No	0	2	3
6	R:R:D92	R:R:Y93	84.5471	27.59	No	No	0	6	4
7	R:R:D92	R:R:Y88	83.9647	6.9	No	No	0	6	5
8	R:R:R91	R:R:Y88	83.3799	2.06	No	No	0	3	5
9	R:R:P96	R:R:R91	80.4193	15.85	No	No	0	4	3
10	R:R:P96	R:R:W95	77.6185	8.11	No	Yes	6	4	8
11	R:R:W85	R:R:W95	70.9341	2.81	Yes	Yes	0	6	8
12	L:L:F53	R:R:W85	10.5498	13.03	No	Yes	0	0	6
13	R:R:L287	R:R:M288	91.7528	4.24	Yes	No	2	4	4
14	R:R:L287	R:R:V267	99.3773	2.98	Yes	No	0	4	4
15	R:R:F291	R:R:V267	49.931	3.93	No	No	0	4	4
16	R:R:F291	R:R:Y264	50.0226	5.16	No	No	0	4	6
17	R:R:K268	R:R:Y264	100	7.17	Yes	No	0	5	6
18	R:R:C294	R:R:V267	49.9017	3.42	No	No	0	6	4
19	R:R:C294	R:R:Y264	50.025	6.72	No	No	0	6	6
20	R:R:L82	R:R:W85	58.6128	2.28	Yes	Yes	0	7	6
21	R:R:F39	R:R:L82	45.979	13.4	Yes	Yes	1	6	7
22	R:R:F39	R:R:Y35	15.7349	3.09	Yes	Yes	1	6	7
23	R:R:L82	R:R:Y299	11.3116	4.69	Yes	Yes	1	7	7
24	R:R:F39	R:R:V79	32.2756	5.24	Yes	No	0	6	6
25	R:R:D75	R:R:V79	31.5382	2.92	Yes	No	0	9	6
26	R:R:D75	R:R:N46	28.5433	9.42	Yes	Yes	0	9	9
27	R:R:G47	R:R:N46	12.2737	3.39	No	Yes	0	3	9
28	R:R:L76	R:R:N46	14.7277	8.24	No	Yes	0	7	9
29	R:R:G47	R:R:L50	11.4728	3.42	No	No	0	3	7
30	R:R:L50	R:R:L76	11.524	4.15	No	No	0	7	7
31	R:R:F54	R:R:L50	21.362	3.65	No	No	0	3	7
32	R:R:F54	R:R:V53	19.7334	3.93	No	No	0	3	6
33	R:R:R317	R:R:V53	18.1022	6.54	Yes	No	0	8	6
34	R:R:K268	R:R:T206	31.3355	6.01	Yes	Yes	7	5	5
35	R:R:F210	R:R:T206	30.6836	2.59	Yes	Yes	7	8	5
36	R:R:F210	R:R:W261	58.0317	6.01	Yes	Yes	0	8	9
37	R:R:F257	R:R:W261	82.6095	9.02	Yes	Yes	0	8	9
38	R:R:F257	R:R:M217	56.7522	3.73	Yes	No	0	8	8
39	R:R:M217	R:R:S124	52.4632	3.07	No	Yes	0	8	9
40	R:R:H265	R:R:K268	59.7873	10.48	Yes	Yes	7	8	5
41	R:R:F210	R:R:H265	30.7654	14.71	Yes	Yes	7	8	8
42	R:R:H265	R:R:M113	29.3259	2.63	Yes	No	0	8	7
43	R:R:M113	R:R:W261	31.6212	2.33	No	Yes	0	7	9
44	R:R:F257	R:R:L120	19.4709	6.09	Yes	No	0	8	8
45	R:R:L120	R:R:Y309	18.2646	4.69	No	Yes	0	8	9
46	R:R:F78	R:R:N112	14.547	12.08	Yes	No	0	6	8
47	R:R:N112	R:R:V111	11.3311	2.96	No	No	0	8	4
48	R:R:C220	R:R:S124	27.1015	5.16	No	Yes	8	6	9
49	R:R:S124	R:R:Y221	17.1035	3.82	Yes	Yes	8	9	8
50	R:R:C220	R:R:Y128	26.8512	5.38	No	Yes	0	6	8
51	R:R:V132	R:R:Y128	12.9525	2.52	No	Yes	0	7	8
52	R:R:I250	R:R:Y221	15.2258	4.84	No	Yes	0	7	8
53	R:R:I250	R:R:L246	14.011	2.85	No	No	0	7	7
54	R:R:I228	R:R:L246	11.524	5.71	No	No	0	8	7
55	R:R:F232	R:R:I228	10.3117	3.77	No	No	0	4	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:C44	R:R:Y271	2.69	0	No	No	0	4	0	1
L:L:M45	R:R:Y93	2.39	2	Yes	No	0	4	0	1
L:L:P46	R:R:M288	3.35	2	No	No	0	4	0	1
L:L:L47	R:R:Y185	5.86	0	No	No	0	5	0	1
L:L:H48	R:R:R168	19.18	5	No	Yes	0	5	0	1
L:L:H48	R:R:M183	9.19	5	No	Yes	0	5	0	1
L:L:S49	R:R:L173	3	3	No	Yes	0	3	0	1
L:L:S49	R:R:Q180	5.78	3	No	No	0	2	0	1
L:L:V51	R:R:W85	3.68	0	No	Yes	0	6	0	1
L:L:P52	R:R:W85	2.7	0	No	Yes	0	6	0	1
L:L:F53	R:R:W85	13.03	0	No	Yes	0	6	0	1
L:L:F53	R:R:I109	8.79	0	No	No	0	6	0	1
L:L:P54	R:R:F110	4.33	0	No	No	0	5	0	1
R:R:F78	R:R:I109	5.02	0	Yes	No	6	6	2	1
R:R:I109	R:R:T81	3.04	0	No	No	6	7	1	2
R:R:L82	R:R:W85	2.28	1	Yes	Yes	7	6	2	1
R:R:W85	R:R:W95	2.81	0	Yes	Yes	6	8	1	2
R:R:D92	R:R:Y93	27.59	0	No	No	6	4	2	1
R:R:K178	R:R:Y93	2.39	0	No	No	2	4	2	1
R:R:R168	R:R:S106	9.22	5	Yes	No	5	5	1	2
R:R:F110	R:R:Y114	8.25	0	No	Yes	5	6	1	2
R:R:L167	R:R:V164	4.47	0	No	No	5	4	2	2
R:R:R168	R:R:V164	3.92	5	Yes	No	5	4	1	2
R:R:L167	R:R:M183	7.07	0	No	Yes	5	5	2	1
R:R:M183	R:R:R168	2.48	5	Yes	Yes	5	5	1	1
R:R:E174	R:R:L173	3.98	0	No	Yes	2	3	2	1
R:R:L173	R:R:T176	4.42	3	Yes	No	3	3	1	2
R:R:L173	R:R:Q180	14.64	3	Yes	No	3	2	1	1
R:R:K178	R:R:T176	7.51	0	No	No	2	3	2	2
R:R:Q180	R:R:Y182	7.89	3	No	Yes	2	4	1	2
R:R:M183	R:R:Y185	4.79	5	Yes	No	5	5	1	1
R:R:E198	R:R:M183	4.06	5	Yes	Yes	4	5	2	1
R:R:E194	R:R:Y185	4.49	5	No	No	6	5	2	1
R:R:E194	R:R:E198	7.61	5	No	Yes	6	4	2	2
R:R:L287	R:R:Y271	3.52	2	Yes	No	4	4	2	1
R:R:M288	R:R:Y271	2.39	2	No	No	4	4	1	1
R:R:L287	R:R:M288	4.24	2	Yes	No	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7W0O_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.06
Number of Linked Nodes	287
Number of Links	313
Number of Hubs	38
Number of Links mediated by Hubs	143
Number of Communities	11
Number of Nodes involved in Communities	54
Number of Links involved in Communities	65

Path Summary
Number Of Nodes in MetaPath	56
Number Of Links MetaPath	55
Number of Shortest Paths	105051
Length Of Smallest Path	3
Average Path Length	23.0041
Length of Longest Path	44
Minimum Path Strength	1.3
Average Path Strength	6.1146
Maximum Path Strength	17.245
Minimum Path Correlation	0.7
Average Path Correlation	0.934802
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.85714
Average % Of Corr. Nodes	33.9123
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.1088
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • apelin receptor binding • signaling receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • molecular transducer activity • molecular function activator activity • signaling receptor activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • apelin receptor signaling pathway • heart development • circulatory system development • regulation of localization • negative adaptation of signaling pathway • regulation of G protein-coupled receptor internalization • receptor internalization • negative regulation of biological process • regulation of signal transduction • regulation of receptor internalization • vesicle-mediated transport • negative regulation of G protein-coupled receptor signaling pathway • localization • positive regulation of endocytosis • regulation of G protein-coupled receptor signaling pathway • positive regulation of receptor-mediated endocytosis • positive regulation of G protein-coupled receptor internalization • establishment of localization • positive regulation of receptor internalization • regulation of response to stimulus • adaptation of signaling pathway • receptor-mediated endocytosis • import into cell • regulation of cellular component organization • positive regulation of cellular component organization • transport • negative regulation of signaling • positive regulation of biological process • desensitization of G protein-coupled receptor signaling pathway • negative regulation of cell communication • cellular component organization • negative regulation of cellular process • cellular component organization or biogenesis • positive regulation of cellular process • regulation of endocytosis • G protein-coupled receptor internalization • regulation of signaling • regulation of transport • negative regulation of response to stimulus • regulation of receptor-mediated endocytosis • regulation of vesicle-mediated transport • negative regulation of signal transduction • positive regulation of transport • regulation of cell communication • endocytosis • mesodermal cell migration • mesoderm morphogenesis • mesoderm migration involved in gastrulation • embryo development • tissue migration • ameboidal-type cell migration • cell migration • cell motility • mesoderm formation • mesoderm development • formation of primary germ layer • embryonic morphogenesis • tissue development • gastrulation • anatomical structure morphogenesis • tissue morphogenesis • anatomical structure formation involved in morphogenesis • cell migration involved in gastrulation • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • cellular developmental process • blood vessel morphogenesis • tube development • vasculogenesis • vasculature development • tube morphogenesis • cell differentiation • blood vessel development • angiogenesis • regulation of developmental process • regulation of vasculature development • positive regulation of developmental process • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • positive regulation of angiogenesis • positive regulation of vasculature development • regulation of angiogenesis • positive regulation of multicellular organismal process • regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis • positive regulation of cell population proliferation • endothelial cell proliferation • positive regulation of endothelial cell proliferation • epithelial cell proliferation • positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis • blood vessel endothelial cell proliferation involved in sprouting angiogenesis • positive regulation of epithelial cell proliferation • sprouting angiogenesis • regulation of endothelial cell proliferation • regulation of cell population proliferation • regulation of epithelial cell proliferation • mesendoderm migration • epithelium migration • endoderm development • cell migration involved in mesendoderm migration • mesendoderm development • multi-multicellular organism process • positive regulation of locomotion • regulation of cell motility • regulation of trophoblast cell migration • regulation of reproductive process • reproductive process • positive regulation of cell migration • positive regulation of cell motility • regulation of cell migration • female pregnancy • embryo implantation • locomotion • positive regulation of reproductive process • trophoblast cell migration • positive regulation of trophoblast cell migration • regulation of locomotion • multi-organism reproductive process • adult heart development • epithelium development • embryonic heart tube development • embryonic organ development • coronary vasculature development • heart process • regulation of heart contraction • regulation of system process • positive regulation of blood circulation • positive regulation of heart contraction • circulatory system process • regulation of blood circulation • heart contraction • blood circulation • placenta blood vessel development • placenta development • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • peptide receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • transmembrane signaling receptor activity • apelin receptor activity • mechanoreceptor activity • electron transport chain • metabolic process • generation of precursor metabolites and energy • atrioventricular valve development • heart valve development • cardiac chamber morphogenesis • heart morphogenesis • ventricular septum development • cardiac septum development • cardiac septum morphogenesis • ventricular septum morphogenesis • cardiac chamber development • animal organ morphogenesis • cardiac ventricle development • regulation of body fluid levels • regulation of biological quality • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of metabolic process • mesenchyme morphogenesis • endocardial cushion morphogenesis • mesenchyme development • endocardial cushion formation • endocardial cushion development • artery development • aorta development • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • venous blood vessel development • regulation of calcium ion transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • intracellular calcium ion homeostasis • calcium ion transport • positive regulation of monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation homeostasis • monoatomic cation transport • intracellular monoatomic ion homeostasis • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • inorganic ion transmembrane transport • inorganic cation transmembrane transport • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • chemical homeostasis • cellular localization • inorganic ion homeostasis • homeostatic process • monoatomic ion transmembrane transport • calcium ion homeostasis • regulation of monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • metal ion transport • maintenance of location in cell • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • monoatomic ion transport • intracellular chemical homeostasis • positive regulation of release of sequestered calcium ion into cytosol • regulation of metal ion transport • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • sequestering of calcium ion • cellular homeostasis • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • negative regulation of muscle adaptation • striated muscle adaptation • negative regulation of muscle hypertrophy • regulation of muscle hypertrophy • regulation of cardiac muscle hypertrophy in response to stress • muscle adaptation • cardiac muscle adaptation • regulation of response to stress • response to stress • cardiac muscle hypertrophy • cardiac muscle hypertrophy in response to stress • muscle hypertrophy • regulation of muscle adaptation • negative regulation of cardiac muscle hypertrophy in response to stress • striated muscle hypertrophy • regulation of muscle system process • muscle system process • regulation of cardiac muscle hypertrophy • negative regulation of cardiac muscle adaptation • negative regulation of multicellular organismal process • regulation of cardiac muscle adaptation • negative regulation of cardiac muscle hypertrophy • muscle hypertrophy in response to stress • negative regulation of intracellular signal transduction • cAMP-mediated signaling • negative regulation of cAMP-mediated signaling • regulation of cAMP-mediated signaling • negative regulation of metabolic process • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of macromolecule metabolic process • positive regulation of cardiac muscle hypertrophy • positive regulation of cardiac muscle hypertrophy in response to stress • positive regulation of muscle adaptation • positive regulation of cardiac muscle adaptation • positive regulation of muscle hypertrophy • smooth muscle cell differentiation • muscle cell differentiation • muscle structure development • vascular associated smooth muscle cell differentiation • gap junction assembly • regulation of gap junction assembly • regulation of cellular component biogenesis • cellular component biogenesis • regulation of cell junction assembly • cell junction organization • cellular component assembly • cell junction assembly • cell-cell junction assembly • cell-cell junction organization • pattern specification process • embryonic heart tube morphogenesis • heart looping • determination of bilateral symmetry • epithelial tube morphogenesis • determination of left/right symmetry • specification of symmetry • embryonic organ morphogenesis • morphogenesis of an epithelium • determination of heart left/right asymmetry • regionalization • left/right pattern formation • periplasmic space
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35414
Sequence	>7W0O_nogp_Chain_R S S G A L I P A I Y M L V F L L G T T G N G L V L W T V F R S S R E K R R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D Y D W P F G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R P V A N A R L R L R V S G A V A T A V L W V L A A L L A M P V M V L R T T G D L E N T T K V Q C Y M D Y S M V A T V S S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R K E R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L L H W P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R F R Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8Z74	A	Peptide	Apelin	Apelin	Homo sapiens	Agonistic antibody	-	-	3.01	2025-01-22	10.1038/s41467-024-55555-6
	8XQJ	A	Peptide	Apelin	Apelin	Homo sapiens	JN241	-	-	2.95	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQI	A	Peptide	Apelin	Apelin	Homo sapiens	-	-	-	3.25	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8Z7J	A	Peptide	Apelin	Apelin	Homo sapiens	Agonistic antibody	-	Gi1/β1/γ2	3.12	2025-01-22	10.1038/s41467-024-55555-6
	8Z7J (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Agonistic antibody	-		3.12	2025-01-22	10.1038/s41467-024-55555-6
	8XQF	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-	Gi1/β1/γ2	3.13	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQF (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-		3.13	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQE	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-	Gi1/β1/γ2	3.48	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQE (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-		3.48	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8S4D	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-	-	2.58	2024-12-04	doi.org/10.1038/s41467-024-55381-w
	8XZJ	A	Peptide	Apelin	Apelin	Homo sapiens	WN353	-	Gi1/β1/γ2	3	2024-03-20	10.1016/j.cell.2024.02.004
	8XZJ (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	WN353	-		3	2024-03-20	10.1016/j.cell.2024.02.004
	8XZI	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-	Gi1/β1/γ2	2.7	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZI (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-		2.7	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZH	A	Peptide	Apelin	Apelin	Homo sapiens	MM07	-	Gi1/β1/γ2	2.06	2024-03-20	10.1016/j.cell.2024.02.004
	8XZH (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	MM07	-		2.06	2024-03-20	10.1016/j.cell.2024.02.004
	8XZG	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-	Gi1/β1/γ2	3.2	2024-03-20	10.1016/j.cell.2024.02.004
	8XZG (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-		3.2	2024-03-20	10.1016/j.cell.2024.02.004
	8XZF	A	Peptide	Apelin	Apelin	Homo sapiens	WN561	-	Gi1/β1/γ2	3	2024-03-20	10.1016/j.cell.2024.02.004
	8XZF (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	WN561	-		3	2024-03-20	10.1016/j.cell.2024.02.004
	7SUS	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-	-	2.7	2022-07-27	10.1038/s41594-022-00797-5
	7W0P	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-	Gi1/β1/γ2	3.16	2022-07-27	10.1038/s41594-022-00797-5
	7W0P (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-		3.16	2022-07-27	10.1038/s41594-022-00797-5
	7W0O	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-	Gi1/β1/γ2	3.78	2022-07-27	10.1038/s41594-022-00797-5
	7W0O (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-		3.78	2022-07-27	10.1038/s41594-022-00797-5
	7W0N	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-	Gi1/β1/γ2	4.21	2022-07-27	10.1038/s41594-022-00797-5
	7W0N (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-		4.21	2022-07-27	10.1038/s41594-022-00797-5
	7W0M	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-	Gi1/β1/γ2	3.71	2022-07-27	10.1038/s41594-022-00797-5
	7W0M (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-		3.71	2022-07-27	10.1038/s41594-022-00797-5
	7W0L	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-	Gi1/β1/γ2	3.57	2022-07-27	10.1038/s41594-022-00797-5
	7W0L (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-		3.57	2022-07-27	10.1038/s41594-022-00797-5
	6KNM	A	Peptide	Apelin	Apelin	Homo sapiens	JN241-9	-	-	3.2	2020-01-29	10.1126/sciadv.aax7379
	5VBL	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin mimetic peptide agonist	-	-	2.6	2017-05-31	10.1016/j.str.2017.04.008

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