psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:L40	L:L:R42	12.15	No	No	0	0	0
2	L:L:Q41	L:L:R43	4.67	No	No	0	0	0
3	L:L:M45	L:L:R42	2.48	Yes	No	0	0	0
4	L:L:C44	L:L:L47	3.17	No	No	0	0	0
5	L:L:C44	R:R:Y271	2.69	No	No	0	0	4
6	L:L:M45	L:L:P46	6.71	Yes	No	2	0	0
7	L:L:M45	L:L:R50	4.96	Yes	No	2	0	0
8	L:L:M45	R:R:Y93	2.39	Yes	No	0	0	4
9	L:L:P46	L:L:R50	2.88	No	No	2	0	0
10	L:L:P46	R:R:M288	3.35	No	No	2	0	4
11	L:L:L47	R:R:Y185	5.86	No	No	0	0	5
12	L:L:H48	L:L:P54	9.15	No	No	0	0	0
13	L:L:H48	R:R:R168	19.18	No	Yes	5	0	5
14	L:L:H48	R:R:M183	9.19	No	Yes	5	0	5
15	L:L:S49	R:R:L173	3	No	Yes	3	0	3
16	L:L:S49	R:R:Q180	5.78	No	No	3	0	2
17	L:L:V51	R:R:W85	3.68	No	Yes	0	0	6
18	L:L:P52	R:R:W85	2.7	No	Yes	0	0	6
19	L:L:F53	R:R:W85	13.03	No	Yes	0	0	6
20	L:L:F53	R:R:I109	8.79	No	No	0	0	6
21	L:L:P54	R:R:F110	4.33	No	No	0	0	5
22	R:R:S26	R:R:S27	3.26	No	No	0	3	3
23	R:R:N289	R:R:S26	7.45	No	No	0	2	3
24	R:R:G28	R:R:S27	3.71	No	No	0	3	3
25	R:R:L30	R:R:Y90	2.34	No	Yes	0	5	3
26	R:R:I31	R:R:P32	5.08	No	Yes	1	6	5
27	R:R:I31	R:R:Y35	12.09	No	Yes	1	6	7
28	R:R:P32	R:R:Y35	2.78	Yes	Yes	1	5	7
29	R:R:M36	R:R:P32	3.35	No	Yes	0	3	5
30	R:R:P32	R:R:T89	3.5	Yes	No	1	5	5
31	R:R:P32	R:R:Y90	9.74	Yes	Yes	1	5	3
32	R:R:I34	R:R:Y35	4.84	No	Yes	0	5	7
33	R:R:F39	R:R:Y35	3.09	Yes	Yes	1	6	7
34	R:R:T295	R:R:Y35	7.49	No	Yes	0	5	7
35	R:R:F39	R:R:V79	5.24	Yes	No	0	6	6
36	R:R:F39	R:R:L82	13.4	Yes	Yes	1	6	7
37	R:R:F39	R:R:Y299	6.19	Yes	Yes	1	6	7
38	R:R:N46	R:R:T43	2.92	Yes	No	0	9	5
39	R:R:G45	R:R:T44	3.64	No	No	0	8	4
40	R:R:G47	R:R:N46	3.39	No	Yes	0	3	9
41	R:R:D75	R:R:N46	9.42	Yes	Yes	0	9	9
42	R:R:L76	R:R:N46	8.24	No	Yes	0	7	9
43	R:R:G47	R:R:L50	3.42	No	No	0	3	7
44	R:R:A72	R:R:V49	3.39	No	No	0	8	8
45	R:R:F54	R:R:L50	3.65	No	No	0	3	7
46	R:R:L50	R:R:L76	4.15	No	No	0	7	7
47	R:R:R55	R:R:W51	13.99	No	No	0	6	3
48	R:R:R317	R:R:T52	5.17	Yes	No	0	8	7
49	R:R:F54	R:R:V53	3.93	No	No	0	3	6
50	R:R:R317	R:R:V53	6.54	Yes	No	0	8	6
51	R:R:R61	R:R:S56	2.64	No	No	0	6	5
52	R:R:K60	R:R:S57	3.06	No	No	0	6	6
53	R:R:R61	R:R:S57	5.27	No	No	0	6	6
54	R:R:K60	R:R:R58	3.71	No	No	0	6	6
55	R:R:D65	R:R:R61	11.91	No	No	0	8	6
56	R:R:D65	R:R:I68	4.2	No	No	9	8	8
57	R:R:D65	R:R:R317	9.53	No	Yes	9	8	8
58	R:R:F67	R:R:I66	3.77	No	No	0	7	5
59	R:R:D126	R:R:F67	2.39	No	No	0	8	7
60	R:R:F67	R:R:T150	5.19	No	No	0	7	6
61	R:R:I68	R:R:R317	11.27	No	Yes	9	8	8
62	R:R:C119	R:R:L71	3.17	No	No	0	7	9
63	R:R:L71	R:R:N305	4.12	No	No	0	9	9
64	R:R:L71	R:R:Y309	2.34	No	Yes	0	9	9
65	R:R:D75	R:R:V79	2.92	Yes	No	0	9	6
66	R:R:D75	R:R:S302	4.42	Yes	No	0	9	8
67	R:R:D75	R:R:P306	3.22	Yes	No	0	9	9
68	R:R:L76	R:R:V80	2.98	No	No	0	7	4
69	R:R:T77	R:R:V80	3.17	No	No	0	7	4
70	R:R:F78	R:R:I109	5.02	Yes	No	0	6	6
71	R:R:F78	R:R:N112	12.08	Yes	No	0	6	8
72	R:R:F78	R:R:Y299	7.22	Yes	Yes	0	6	7
73	R:R:F78	R:R:S302	3.96	Yes	No	0	6	8
74	R:R:I109	R:R:T81	3.04	No	No	0	6	7
75	R:R:L82	R:R:W85	2.28	Yes	Yes	0	7	6
76	R:R:L82	R:R:Y299	4.69	Yes	Yes	1	7	7
77	R:R:L84	R:R:W95	3.42	No	Yes	6	6	8
78	R:R:F97	R:R:L84	7.31	Yes	No	6	6	6
79	R:R:F101	R:R:L84	2.44	No	No	6	5	6
80	R:R:W85	R:R:W95	2.81	Yes	Yes	0	6	8
81	R:R:T87	R:R:Y90	6.24	No	Yes	0	4	3
82	R:R:R91	R:R:Y88	2.06	No	No	0	3	5
83	R:R:D92	R:R:Y88	6.9	No	No	0	6	5
84	R:R:T89	R:R:Y90	3.75	No	Yes	1	5	3
85	R:R:D94	R:R:R91	8.34	No	No	0	4	3
86	R:R:P96	R:R:R91	15.85	No	No	0	4	3
87	R:R:D92	R:R:Y93	27.59	No	No	0	6	4
88	R:R:K178	R:R:Y93	2.39	No	No	0	2	4
89	R:R:D94	R:R:V179	2.92	No	No	0	4	5
90	R:R:P96	R:R:W95	8.11	No	Yes	6	4	8
91	R:R:F97	R:R:W95	3.01	Yes	Yes	6	6	8
92	R:R:G98	R:R:W95	2.81	No	Yes	0	8	8
93	R:R:F101	R:R:W95	6.01	No	Yes	6	5	8
94	R:R:C102	R:R:W95	11.75	No	Yes	0	9	8
95	R:R:F97	R:R:P96	8.67	Yes	No	6	6	4
96	R:R:F101	R:R:F97	17.15	No	Yes	6	5	6
97	R:R:K103	R:R:T99	3	No	No	0	7	3
98	R:R:T170	R:R:T99	10.99	No	No	0	5	3
99	R:R:F100	R:R:L104	2.44	No	No	0	1	5
100	R:R:C102	R:R:C181	5.46	No	No	0	9	9
101	R:R:K103	R:R:V166	3.04	No	No	0	7	4
102	R:R:R168	R:R:S106	9.22	Yes	No	0	5	5
103	R:R:A161	R:R:Y107	2.67	No	Yes	0	7	5
104	R:R:M162	R:R:Y107	3.59	Yes	Yes	10	4	5
105	R:R:M165	R:R:Y107	4.79	No	Yes	10	5	5
106	R:R:F110	R:R:Y114	8.25	No	Yes	0	5	6
107	R:R:N112	R:R:V111	2.96	No	No	0	8	4
108	R:R:M113	R:R:Y114	9.58	No	Yes	0	7	6
109	R:R:M113	R:R:W261	2.33	No	Yes	0	7	9
110	R:R:H265	R:R:M113	2.63	Yes	No	0	8	7
111	R:R:F118	R:R:Y114	2.06	Yes	Yes	4	5	6
112	R:R:L160	R:R:Y114	10.55	No	Yes	4	4	6
113	R:R:S205	R:R:Y114	3.82	No	Yes	0	4	6
114	R:R:S116	R:R:W261	3.71	No	Yes	0	9	9
115	R:R:F118	R:R:V117	2.62	Yes	No	4	5	7
116	R:R:G209	R:R:V117	3.68	No	No	4	5	7
117	R:R:P213	R:R:V117	3.53	No	No	4	9	7
118	R:R:F118	R:R:L153	6.09	Yes	No	0	5	6
119	R:R:A157	R:R:F118	2.77	No	Yes	0	7	5
120	R:R:F118	R:R:L160	2.44	Yes	No	4	5	4
121	R:R:F257	R:R:L120	6.09	Yes	No	0	8	8
122	R:R:L120	R:R:Y309	4.69	No	Yes	0	8	9
123	R:R:I216	R:R:T121	4.56	No	No	0	6	7
124	R:R:M217	R:R:T121	6.02	No	No	0	8	7
125	R:R:L123	R:R:Y309	4.69	No	Yes	0	8	9
126	R:R:R127	R:R:S124	3.95	No	Yes	8	9	9
127	R:R:M217	R:R:S124	3.07	No	Yes	0	8	9
128	R:R:C220	R:R:S124	5.16	No	Yes	8	6	9
129	R:R:S124	R:R:Y221	3.82	Yes	Yes	8	9	8
130	R:R:F125	R:R:Y128	3.09	No	Yes	0	6	8
131	R:R:D126	R:R:R127	3.57	No	No	0	8	9
132	R:R:R127	R:R:Y221	6.17	No	Yes	8	9	8
133	R:R:V132	R:R:Y128	2.52	No	Yes	0	7	8
134	R:R:C220	R:R:Y128	5.38	No	Yes	0	6	8
135	R:R:F223	R:R:Y128	8.25	No	Yes	0	5	8
136	R:R:L129	R:R:N137	5.49	No	No	0	5	6
137	R:R:I131	R:R:I224	2.94	No	No	0	8	8
138	R:R:N137	R:R:V132	2.96	No	No	0	6	7
139	R:R:A136	R:R:R133	2.77	No	No	0	4	6
140	R:R:N137	R:R:R133	3.62	No	No	0	6	6
141	R:R:A138	R:R:R141	5.53	No	No	0	5	7
142	R:R:L140	R:R:R143	7.29	No	No	0	4	3
143	R:R:L140	R:R:V144	2.98	No	No	0	4	4
144	R:R:L156	R:R:V152	2.98	No	No	0	4	2
145	R:R:V155	R:R:W154	4.9	No	No	0	4	9
146	R:R:M162	R:R:M165	7.22	Yes	No	10	4	5
147	R:R:L167	R:R:V164	4.47	No	No	0	5	4
148	R:R:R168	R:R:V164	3.92	Yes	No	0	5	4
149	R:R:L167	R:R:M183	7.07	No	Yes	0	5	5
150	R:R:M183	R:R:R168	2.48	Yes	Yes	5	5	5
151	R:R:T169	R:R:Y182	3.75	No	Yes	3	4	4
152	R:R:D184	R:R:T169	14.45	No	No	3	3	4
153	R:R:C181	R:R:T170	5.07	No	No	0	9	5
154	R:R:G171	R:R:Y182	4.35	No	Yes	0	1	4
155	R:R:D172	R:R:T177	8.67	No	No	0	1	5
156	R:R:D172	R:R:V179	4.38	No	No	0	1	5
157	R:R:E174	R:R:L173	3.98	No	Yes	0	2	3
158	R:R:L173	R:R:T176	4.42	Yes	No	0	3	3
159	R:R:L173	R:R:Q180	14.64	Yes	No	3	3	2
160	R:R:E174	R:R:N175	6.57	No	No	0	2	2
161	R:R:N175	R:R:T176	5.85	No	No	0	2	3
162	R:R:K178	R:R:T176	7.51	No	No	0	2	3
163	R:R:Q180	R:R:Y182	7.89	No	Yes	3	2	4
164	R:R:D184	R:R:Y182	4.6	No	Yes	3	3	4
165	R:R:M183	R:R:Y185	4.79	Yes	No	0	5	5
166	R:R:E198	R:R:M183	4.06	Yes	Yes	5	4	5
167	R:R:D184	R:R:S186	7.36	No	No	0	3	5
168	R:R:E194	R:R:Y185	4.49	No	No	0	6	5
169	R:R:E194	R:R:M187	8.12	No	No	5	6	2
170	R:R:E198	R:R:M187	2.71	Yes	No	5	4	2
171	R:R:A189	R:R:S193	3.42	No	No	0	1	4
172	R:R:S193	R:R:T190	4.8	No	No	0	4	1
173	R:R:S193	R:R:W197	2.47	No	No	0	4	2
174	R:R:E194	R:R:E198	7.61	No	Yes	5	6	4
175	R:R:V199	R:R:W195	7.36	No	No	0	3	2
176	R:R:K268	R:R:S205	3.06	Yes	No	0	5	4
177	R:R:F210	R:R:T206	2.59	Yes	Yes	7	8	5
178	R:R:H265	R:R:T206	9.58	Yes	Yes	7	8	5
179	R:R:K268	R:R:T206	6.01	Yes	Yes	7	5	5
180	R:R:T206	R:R:T269	3.14	Yes	No	0	5	6
181	R:R:G209	R:R:V208	3.68	No	No	0	5	5
182	R:R:G209	R:R:P213	4.06	No	No	4	5	9
183	R:R:F210	R:R:W261	6.01	Yes	Yes	0	8	9
184	R:R:F210	R:R:M262	8.71	Yes	No	0	8	5
185	R:R:F210	R:R:H265	14.71	Yes	Yes	7	8	8
186	R:R:P213	R:R:V212	7.07	No	No	0	9	6
187	R:R:I216	R:R:V212	3.07	No	No	0	6	6
188	R:R:F214	R:R:L218	2.44	No	No	0	6	4
189	R:R:A258	R:R:F214	2.77	No	No	0	5	6
190	R:R:I216	R:R:T215	3.04	No	No	0	6	2
191	R:R:F257	R:R:M217	3.73	Yes	No	0	8	8
192	R:R:F223	R:R:T219	9.08	No	No	0	5	4
193	R:R:C220	R:R:Y221	4.03	No	Yes	8	6	8
194	R:R:I250	R:R:Y221	4.84	No	Yes	0	7	8
195	R:R:L253	R:R:Y221	7.03	Yes	Yes	0	7	8
196	R:R:F222	R:R:F223	2.14	No	No	0	3	5
197	R:R:F222	R:R:Q226	12.88	No	No	0	3	3
198	R:R:I224	R:R:T227	4.56	No	No	0	8	4
199	R:R:F232	R:R:I228	3.77	No	No	0	4	8
200	R:R:I228	R:R:L246	5.71	No	No	0	8	7
201	R:R:F232	R:R:R243	2.14	No	Yes	0	4	6
202	R:R:K234	R:R:R236	4.95	No	No	0	3	2
203	R:R:E235	R:R:R243	16.28	No	Yes	0	4	6
204	R:R:E238	R:R:I237	9.56	No	No	0	4	3
205	R:R:L240	R:R:R243	4.86	No	Yes	0	4	6
206	R:R:K242	R:R:L246	2.82	No	No	0	5	7
207	R:R:L247	R:R:R243	3.64	No	Yes	0	6	6
208	R:R:L247	R:R:R244	3.64	No	No	0	6	5
209	R:R:F312	R:R:R245	9.62	No	No	0	6	7
210	R:R:I250	R:R:L246	2.85	No	No	0	7	7
211	R:R:I249	R:R:L253	2.85	No	Yes	0	7	7
212	R:R:F312	R:R:I249	10.05	No	No	0	6	7
213	R:R:L253	R:R:Y309	7.03	Yes	Yes	0	7	9
214	R:R:L259	R:R:V255	2.98	No	No	0	5	4
215	R:R:L304	R:R:T256	5.9	No	No	11	6	6
216	R:R:L308	R:R:T256	4.42	Yes	No	11	8	6
217	R:R:F257	R:R:W261	9.02	Yes	Yes	0	8	9
218	R:R:C260	R:R:N301	6.3	No	No	0	7	9
219	R:R:N301	R:R:W261	12.43	No	Yes	0	9	9
220	R:R:L266	R:R:M262	4.24	No	No	0	6	5
221	R:R:I297	R:R:P263	5.08	No	No	0	6	9
222	R:R:K268	R:R:Y264	7.17	Yes	No	0	5	6
223	R:R:F291	R:R:Y264	5.16	No	No	0	4	6
224	R:R:C294	R:R:Y264	6.72	No	No	0	6	6
225	R:R:H265	R:R:K268	10.48	Yes	Yes	7	8	5
226	R:R:L287	R:R:V267	2.98	Yes	No	0	4	4
227	R:R:F291	R:R:V267	3.93	No	No	0	4	4
228	R:R:C294	R:R:V267	3.42	No	No	0	6	4
229	R:R:K268	R:R:M272	2.88	Yes	No	0	5	5
230	R:R:L287	R:R:Y271	3.52	Yes	No	2	4	4
231	R:R:M288	R:R:Y271	2.39	No	No	2	4	4
232	R:R:G274	R:R:W279	8.44	No	Yes	0	3	1
233	R:R:H278	R:R:L277	11.57	No	No	0	2	1
234	R:R:H278	R:R:P280	6.1	No	No	0	2	4
235	R:R:F283	R:R:W279	10.02	No	Yes	0	3	1
236	R:R:D284	R:R:W279	8.93	No	Yes	0	4	1
237	R:R:L287	R:R:W279	10.25	Yes	Yes	0	4	1
238	R:R:F283	R:R:P280	7.22	No	No	0	3	4
239	R:R:C281	R:R:D284	4.67	No	No	0	8	4
240	R:R:D282	R:R:F286	11.94	No	No	0	2	1
241	R:R:F283	R:R:F286	4.29	No	No	0	3	1
242	R:R:L285	R:R:N289	2.75	No	No	0	3	2
243	R:R:L287	R:R:M288	4.24	Yes	No	2	4	4
244	R:R:I290	R:R:N289	5.66	No	No	0	4	2
245	R:R:I290	R:R:Y293	4.84	No	No	0	4	5
246	R:R:T295	R:R:Y299	2.5	No	Yes	0	5	7
247	R:R:S298	R:R:Y299	3.82	No	Yes	0	7	7
248	R:R:N301	R:R:V300	2.96	No	No	0	9	5
249	R:R:C303	R:R:V300	3.42	No	No	0	7	5
250	R:R:L304	R:R:N305	2.75	No	No	0	6	9
251	R:R:L304	R:R:L308	2.77	No	Yes	11	6	8
252	R:R:L308	R:R:Y309	4.69	Yes	Yes	0	8	9
253	R:R:F311	R:R:F316	6.43	No	No	0	6	9
254	R:R:P314	R:R:R315	8.65	No	No	0	5	7
255	R:R:A147	R:R:G146	1.95	No	No	0	4	7
256	R:R:A229	R:R:G230	1.95	No	No	0	4	4
257	R:R:A86	R:R:P32	1.87	No	Yes	0	6	5
258	R:R:G146	R:R:S145	1.86	No	No	0	7	4
259	R:R:G202	R:R:S205	1.86	No	No	0	5	4
260	R:R:G200	R:R:V199	1.84	No	No	0	2	3
261	R:R:P306	R:R:V49	1.77	No	No	0	9	8
262	R:R:C102	R:R:S105	1.72	No	No	0	9	5
263	R:R:G42	R:R:L41	1.71	No	No	0	8	5
264	R:R:G122	R:R:L153	1.71	No	No	0	6	6
265	R:R:G202	R:R:L201	1.71	No	No	0	5	4
266	R:R:G274	R:R:L273	1.71	No	No	0	3	4
267	R:R:A310	R:R:V49	1.7	No	No	0	6	8
268	R:R:A149	R:R:V144	1.7	No	No	0	5	4
269	R:R:I31	R:R:P292	1.69	No	No	0	6	4
270	R:R:C296	R:R:T295	1.69	No	No	0	5	5
271	R:R:M162	R:R:P163	1.68	Yes	No	0	4	8
272	R:R:M262	R:R:P263	1.68	No	No	0	5	9
273	R:R:L82	R:R:P83	1.64	Yes	No	0	7	9
274	R:R:A130	R:R:I131	1.62	No	No	0	8	8
275	R:R:A158	R:R:M162	1.61	No	Yes	0	4	4
276	R:R:D313	R:R:P314	1.61	No	No	0	8	5
277	R:R:S192	R:R:T190	1.6	No	No	0	2	1
278	R:R:V211	R:R:V212	1.6	No	No	0	4	6
279	R:R:T207	R:R:V203	1.59	No	No	0	3	4
280	R:R:T207	R:R:V211	1.59	No	No	0	3	4
281	R:R:A29	R:R:L30	1.58	No	No	0	3	5
282	R:R:A64	R:R:L123	1.58	No	No	0	8	8
283	R:R:A258	R:R:L259	1.58	No	No	0	5	5
284	R:R:A74	R:R:N112	1.56	No	No	0	8	8
285	R:R:I224	R:R:V132	1.54	No	No	0	8	7
286	R:R:M272	R:R:S275	1.53	No	No	0	5	4
287	R:R:G239	R:R:R236	1.5	No	No	0	4	2
288	R:R:L276	R:R:S275	1.5	No	No	0	1	4
289	R:R:L37	R:R:V38	1.49	No	No	0	5	7
290	R:R:L253	R:R:V252	1.49	Yes	No	0	7	5
291	R:R:L308	R:R:V252	1.49	Yes	No	0	8	5
292	R:R:L40	R:R:T44	1.47	No	No	0	5	4
293	R:R:L41	R:R:T44	1.47	No	No	0	5	4
294	R:R:D126	R:R:S63	1.47	No	No	0	8	6
295	R:R:L108	R:R:T77	1.47	No	No	0	4	7
296	R:R:P134	R:R:R133	1.44	No	No	0	8	6
297	R:R:P292	R:R:Y293	1.39	No	No	0	4	5
298	R:R:L37	R:R:L41	1.38	No	No	0	5	5
299	R:R:L156	R:R:L159	1.38	No	No	0	4	4
300	R:R:L270	R:R:L273	1.38	No	No	0	5	4
301	R:R:L270	R:R:L287	1.38	No	Yes	0	5	4
302	R:R:R141	R:R:S145	1.32	No	No	0	7	4
303	R:R:F125	R:R:V144	1.31	No	No	0	6	4
304	R:R:V111	R:R:Y107	1.26	No	Yes	0	4	5
305	R:R:V254	R:R:Y221	1.26	No	Yes	0	7	8
306	R:R:K234	R:R:R233	1.24	No	No	0	3	4
307	R:R:F118	R:R:L156	1.22	Yes	No	0	5	4
308	R:R:T52	R:R:W51	1.21	No	No	0	7	3
309	R:R:L142	R:R:R143	1.21	No	No	0	6	3
310	R:R:L240	R:R:R241	1.21	No	No	0	4	4
311	R:R:F232	R:R:H231	1.13	No	No	0	4	5
312	R:R:E198	R:R:W195	1.09	Yes	No	0	4	2
313	R:R:F214	R:R:F257	1.07	No	Yes	0	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:M45	4.135	4	2	0
2	R:R:P32	4.38667	6	1	5
3	R:R:Y35	6.058	5	1	7
4	R:R:F39	6.98	4	1	6
5	R:R:N46	5.9925	4	0	9
6	R:R:D75	4.995	4	0	9
7	R:R:F78	7.07	4	0	6
8	R:R:L82	5.5025	4	1	7
9	R:R:W85	4.9	5	0	6
10	R:R:Y90	5.5175	4	1	3
11	R:R:W95	5.41714	7	6	8
12	R:R:F97	9.035	4	6	6
13	R:R:Y107	3.0775	4	10	5
14	R:R:Y114	6.852	5	4	6
15	R:R:F118	2.86667	6	4	5
16	R:R:S124	4	4	8	9
17	R:R:Y128	4.81	4	0	8
18	R:R:M162	3.525	4	10	4
19	R:R:R168	8.7	4	5	5
20	R:R:L173	6.51	4	3	3
21	R:R:Y182	5.1475	4	3	4
22	R:R:M183	5.518	5	5	5
23	R:R:E198	3.8675	4	5	4
24	R:R:T206	5.33	4	7	5
25	R:R:F210	8.005	4	7	8
26	R:R:Y221	4.525	6	8	8
27	R:R:R243	6.73	4	0	6
28	R:R:L253	4.6	4	0	7
29	R:R:F257	4.9775	4	0	8
30	R:R:W261	6.7	5	0	9
31	R:R:H265	9.35	4	7	8
32	R:R:K268	5.92	5	7	5
33	R:R:W279	9.41	4	0	1
34	R:R:L287	4.474	5	2	4
35	R:R:Y299	4.884	5	1	7
36	R:R:L308	3.3425	4	11	8
37	R:R:Y309	4.688	5	0	9
38	R:R:R317	8.1275	4	9	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:P46	R:R:M288	95.0224	3.35	No	No	2	0	4
2	L:L:M45	L:L:P46	93.8467	6.71	Yes	No	2	0	0
3	L:L:M45	R:R:Y93	92.3743	2.39	Yes	No	0	0	4
4	R:R:K178	R:R:Y93	11.0613	2.39	No	No	0	2	4
5	R:R:K178	R:R:T176	10.225	7.51	No	No	0	2	3
6	R:R:D92	R:R:Y93	84.5471	27.59	No	No	0	6	4
7	R:R:D92	R:R:Y88	83.9647	6.9	No	No	0	6	5
8	R:R:R91	R:R:Y88	83.3799	2.06	No	No	0	3	5
9	R:R:P96	R:R:R91	80.4193	15.85	No	No	0	4	3
10	R:R:P96	R:R:W95	77.6185	8.11	No	Yes	6	4	8
11	R:R:W85	R:R:W95	70.9341	2.81	Yes	Yes	0	6	8
12	L:L:F53	R:R:W85	10.5498	13.03	No	Yes	0	0	6
13	R:R:L287	R:R:M288	91.7528	4.24	Yes	No	2	4	4
14	R:R:L287	R:R:V267	99.3773	2.98	Yes	No	0	4	4
15	R:R:F291	R:R:V267	49.931	3.93	No	No	0	4	4
16	R:R:F291	R:R:Y264	50.0226	5.16	No	No	0	4	6
17	R:R:K268	R:R:Y264	100	7.17	Yes	No	0	5	6
18	R:R:C294	R:R:V267	49.9017	3.42	No	No	0	6	4
19	R:R:C294	R:R:Y264	50.025	6.72	No	No	0	6	6
20	R:R:L82	R:R:W85	58.6128	2.28	Yes	Yes	0	7	6
21	R:R:F39	R:R:L82	45.979	13.4	Yes	Yes	1	6	7
22	R:R:F39	R:R:Y35	15.7349	3.09	Yes	Yes	1	6	7
23	R:R:L82	R:R:Y299	11.3116	4.69	Yes	Yes	1	7	7
24	R:R:F39	R:R:V79	32.2756	5.24	Yes	No	0	6	6
25	R:R:D75	R:R:V79	31.5382	2.92	Yes	No	0	9	6
26	R:R:D75	R:R:N46	28.5433	9.42	Yes	Yes	0	9	9
27	R:R:G47	R:R:N46	12.2737	3.39	No	Yes	0	3	9
28	R:R:L76	R:R:N46	14.7277	8.24	No	Yes	0	7	9
29	R:R:G47	R:R:L50	11.4728	3.42	No	No	0	3	7
30	R:R:L50	R:R:L76	11.524	4.15	No	No	0	7	7
31	R:R:F54	R:R:L50	21.362	3.65	No	No	0	3	7
32	R:R:F54	R:R:V53	19.7334	3.93	No	No	0	3	6
33	R:R:R317	R:R:V53	18.1022	6.54	Yes	No	0	8	6
34	R:R:K268	R:R:T206	31.3355	6.01	Yes	Yes	7	5	5
35	R:R:F210	R:R:T206	30.6836	2.59	Yes	Yes	7	8	5
36	R:R:F210	R:R:W261	58.0317	6.01	Yes	Yes	0	8	9
37	R:R:F257	R:R:W261	82.6095	9.02	Yes	Yes	0	8	9
38	R:R:F257	R:R:M217	56.7522	3.73	Yes	No	0	8	8
39	R:R:M217	R:R:S124	52.4632	3.07	No	Yes	0	8	9
40	R:R:H265	R:R:K268	59.7873	10.48	Yes	Yes	7	8	5
41	R:R:F210	R:R:H265	30.7654	14.71	Yes	Yes	7	8	8
42	R:R:H265	R:R:M113	29.3259	2.63	Yes	No	0	8	7
43	R:R:M113	R:R:W261	31.6212	2.33	No	Yes	0	7	9
44	R:R:F257	R:R:L120	19.4709	6.09	Yes	No	0	8	8
45	R:R:L120	R:R:Y309	18.2646	4.69	No	Yes	0	8	9
46	R:R:F78	R:R:N112	14.547	12.08	Yes	No	0	6	8
47	R:R:N112	R:R:V111	11.3311	2.96	No	No	0	8	4
48	R:R:C220	R:R:S124	27.1015	5.16	No	Yes	8	6	9
49	R:R:S124	R:R:Y221	17.1035	3.82	Yes	Yes	8	9	8
50	R:R:C220	R:R:Y128	26.8512	5.38	No	Yes	0	6	8
51	R:R:V132	R:R:Y128	12.9525	2.52	No	Yes	0	7	8
52	R:R:I250	R:R:Y221	15.2258	4.84	No	Yes	0	7	8
53	R:R:I250	R:R:L246	14.011	2.85	No	No	0	7	7
54	R:R:I228	R:R:L246	11.524	5.71	No	No	0	8	7
55	R:R:F232	R:R:I228	10.3117	3.77	No	No	0	4	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:C44	R:R:Y271	2.69	0	No	No	0	4	0	1
L:L:M45	R:R:Y93	2.39	2	Yes	No	0	4	0	1
L:L:P46	R:R:M288	3.35	2	No	No	0	4	0	1
L:L:L47	R:R:Y185	5.86	0	No	No	0	5	0	1
L:L:H48	R:R:R168	19.18	5	No	Yes	0	5	0	1
L:L:H48	R:R:M183	9.19	5	No	Yes	0	5	0	1
L:L:S49	R:R:L173	3	3	No	Yes	0	3	0	1
L:L:S49	R:R:Q180	5.78	3	No	No	0	2	0	1
L:L:V51	R:R:W85	3.68	0	No	Yes	0	6	0	1
L:L:P52	R:R:W85	2.7	0	No	Yes	0	6	0	1
L:L:F53	R:R:W85	13.03	0	No	Yes	0	6	0	1
L:L:F53	R:R:I109	8.79	0	No	No	0	6	0	1
L:L:P54	R:R:F110	4.33	0	No	No	0	5	0	1
R:R:F78	R:R:I109	5.02	0	Yes	No	6	6	2	1
R:R:I109	R:R:T81	3.04	0	No	No	6	7	1	2
R:R:L82	R:R:W85	2.28	1	Yes	Yes	7	6	2	1
R:R:W85	R:R:W95	2.81	0	Yes	Yes	6	8	1	2
R:R:D92	R:R:Y93	27.59	0	No	No	6	4	2	1
R:R:K178	R:R:Y93	2.39	0	No	No	2	4	2	1
R:R:R168	R:R:S106	9.22	5	Yes	No	5	5	1	2
R:R:F110	R:R:Y114	8.25	0	No	Yes	5	6	1	2
R:R:L167	R:R:V164	4.47	0	No	No	5	4	2	2
R:R:R168	R:R:V164	3.92	5	Yes	No	5	4	1	2
R:R:L167	R:R:M183	7.07	0	No	Yes	5	5	2	1
R:R:M183	R:R:R168	2.48	5	Yes	Yes	5	5	1	1
R:R:E174	R:R:L173	3.98	0	No	Yes	2	3	2	1
R:R:L173	R:R:T176	4.42	3	Yes	No	3	3	1	2
R:R:L173	R:R:Q180	14.64	3	Yes	No	3	2	1	1
R:R:K178	R:R:T176	7.51	0	No	No	2	3	2	2
R:R:Q180	R:R:Y182	7.89	3	No	Yes	2	4	1	2
R:R:M183	R:R:Y185	4.79	5	Yes	No	5	5	1	1
R:R:E198	R:R:M183	4.06	5	Yes	Yes	4	5	2	1
R:R:E194	R:R:Y185	4.49	5	No	No	6	5	2	1
R:R:E194	R:R:E198	7.61	5	No	Yes	6	4	2	2
R:R:L287	R:R:Y271	3.52	2	Yes	No	4	4	2	1
R:R:M288	R:R:Y271	2.39	2	No	No	4	4	1	1
R:R:L287	R:R:M288	4.24	2	Yes	No	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7W0O_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.06
Number of Linked Nodes	287
Number of Links	313
Number of Hubs	38
Number of Links mediated by Hubs	143
Number of Communities	11
Number of Nodes involved in Communities	54
Number of Links involved in Communities	65

Path Summary
Number Of Nodes in MetaPath	56
Number Of Links MetaPath	55
Number of Shortest Paths	105051
Length Of Smallest Path	3
Average Path Length	23.0041
Length of Longest Path	44
Minimum Path Strength	1.3
Average Path Strength	6.1146
Maximum Path Strength	17.245
Minimum Path Correlation	0.7
Average Path Correlation	0.934793
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.85714
Average % Of Corr. Nodes	33.9772
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.1088
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35414
Sequence	>7W0O_nogp_Chain_R S S G A L I P A I Y M L V F L L G T T G N G L V L W T V F R S S R E K R R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D Y D W P F G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R P V A N A R L R L R V S G A V A T A V L W V L A A L L A M P V M V L R T T G D L E N T T K V Q C Y M D Y S M V A T V S S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R K E R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L L H W P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R F R Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XZF	A	Peptide	Apelin	Apelin	Homo sapiens	WN561	-	Gi1/β1/γ2	3	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZF (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	WN561	-		3	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZG	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-	Gi1/β1/γ2	3.2	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZG (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-		3.2	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZH	A	Peptide	Apelin	Apelin	Homo sapiens	MM07	-	Gi1/β1/γ2	2.06	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZH (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	MM07	-		2.06	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZJ	A	Peptide	Apelin	Apelin	Homo sapiens	WN353	-	Gi1/β1/γ2	3	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZJ (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	WN353	-		3	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	5VBL	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin mimetic peptide agonist	-	-	2.6	2017-05-31	doi.org/10.1016/j.str.2017.04.008
	8Z74	A	Peptide	Apelin	Apelin	Homo sapiens	Agonistic antibody	-	-	3.01	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8Z7J	A	Peptide	Apelin	Apelin	Homo sapiens	Agonistic antibody	-	Gi1/β1/γ2	3.12	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8Z7J (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Agonistic antibody	-		3.12	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	7SUS	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-	-	2.7	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0L	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-	Gi1/β1/γ2	3.57	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0L (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-		3.57	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0M	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-	Gi1/β1/γ2	3.71	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0M (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-		3.71	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0N	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-	Gi1/β1/γ2	4.21	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0N (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-		4.21	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0O	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-	Gi1/β1/γ2	3.78	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0O (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-		3.78	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0P	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-	Gi1/β1/γ2	3.16	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0P (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-		3.16	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	6KNM	A	Peptide	Apelin	Apelin	Homo sapiens	JN241-9	-	-	3.2	2020-01-29	doi.org/10.1126/sciadv.aax7379
	8XZI	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-	Gi1/β1/γ2	2.7	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZI (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-		2.7	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8S4D	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-	-	2.58	2024-12-04	doi.org/10.1038/s41467-024-55381-w
	8XQE	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-	Gi1/β1/γ2	3.48	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQE (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-		3.48	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQF	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-	Gi1/β1/γ2	3.13	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQF (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-		3.13	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQI	A	Peptide	Apelin	Apelin	Homo sapiens	-	-	-	3.25	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQJ	A	Peptide	Apelin	Apelin	Homo sapiens	JN241	-	-	2.95	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	9JH3	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-	Gi1/β1/γ2	2.93	2025-04-23	doi.org/10.1073/pnas.2423432122
	9JH3 (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-		2.93	2025-04-23	doi.org/10.1073/pnas.2423432122

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