psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:P3	L:L:R2	20.18	No	No	0	0	0
2	L:L:R2	R:R:E174	13.96	No	No	0	0	2
3	L:L:L5	R:R:Y271	11.72	No	Yes	0	0	4
4	L:L:L5	R:R:F291	9.74	No	No	0	0	4
5	L:L:H7	L:L:S6	4.18	No	Yes	0	0	0
6	L:L:P12	L:L:S6	3.56	Yes	Yes	1	0	0
7	L:L:S6	R:R:R168	6.59	Yes	Yes	1	0	5
8	L:L:S6	R:R:M183	6.13	Yes	Yes	1	0	5
9	L:L:H7	R:R:Q180	11.13	No	No	0	0	2
10	L:L:K8	R:R:I31	4.36	No	Yes	0	0	6
11	L:L:K8	R:R:T89	9.01	No	No	0	0	5
12	L:L:K8	R:R:Y93	15.53	No	No	0	0	4
13	L:L:G9	L:L:P10	4.06	No	Yes	1	0	0
14	L:L:G9	R:R:Y35	4.35	No	Yes	1	0	7
15	L:L:M11	L:L:P10	6.71	Yes	Yes	1	0	0
16	L:L:P10	R:R:Y35	4.17	Yes	Yes	1	0	7
17	L:L:P10	R:R:W85	21.62	Yes	Yes	1	0	6
18	L:L:P10	R:R:I109	6.77	Yes	Yes	1	0	6
19	L:L:P10	R:R:Y299	8.34	Yes	Yes	1	0	7
20	L:L:M11	R:R:I109	4.37	Yes	Yes	1	0	6
21	L:L:M11	R:R:F110	3.73	Yes	Yes	1	0	5
22	L:L:M11	R:R:Y264	9.58	Yes	Yes	1	0	6
23	L:L:M11	R:R:T295	4.52	Yes	No	1	0	5
24	L:L:M11	R:R:Y299	5.99	Yes	Yes	1	0	7
25	L:L:F13	L:L:P12	8.67	Yes	Yes	0	0	0
26	L:L:P12	R:R:R168	11.53	Yes	Yes	1	0	5
27	L:L:P12	R:R:M183	8.39	Yes	Yes	1	0	5
28	L:L:F13	R:R:F110	9.65	Yes	Yes	0	0	5
29	L:L:F13	R:R:L201	12.18	Yes	No	0	0	4
30	L:L:F13	R:R:S205	3.96	Yes	No	0	0	4
31	R:R:C19	R:R:Y21	4.03	No	No	0	8	4
32	R:R:C19	R:R:C281	7.28	No	No	0	8	8
33	R:R:L285	R:R:Y21	5.86	No	No	0	3	4
34	R:R:S27	R:R:W24	8.65	No	No	6	3	1
35	R:R:N289	R:R:W24	22.6	No	No	0	2	1
36	R:R:W24	R:R:Y293	3.86	No	No	6	1	5
37	R:R:S27	R:R:Y293	3.82	No	No	6	3	5
38	R:R:I31	R:R:P32	6.77	Yes	No	0	6	5
39	R:R:I31	R:R:P292	8.47	Yes	No	0	6	4
40	R:R:I31	R:R:Y293	7.25	Yes	No	0	6	5
41	R:R:P32	R:R:T89	8.74	No	No	0	5	5
42	R:R:P32	R:R:Y90	5.56	No	No	0	5	3
43	R:R:I34	R:R:L37	7.14	No	No	0	5	5
44	R:R:C296	R:R:I34	4.91	No	No	0	5	5
45	R:R:L82	R:R:Y35	7.03	No	Yes	0	7	7
46	R:R:T295	R:R:Y35	4.99	No	Yes	1	5	7
47	R:R:V300	R:R:V38	6.41	No	No	0	5	7
48	R:R:F39	R:R:T43	3.89	No	No	0	6	5
49	R:R:F39	R:R:P83	18.78	No	No	0	6	9
50	R:R:G42	R:R:V79	5.52	No	No	0	8	6
51	R:R:C303	R:R:G42	3.92	No	No	0	7	8
52	R:R:L76	R:R:T43	4.42	No	No	0	7	5
53	R:R:G45	R:R:T44	3.64	No	No	0	8	4
54	R:R:D75	R:R:N46	13.46	No	No	0	9	9
55	R:R:L76	R:R:N46	6.87	No	No	0	7	9
56	R:R:N46	R:R:P306	8.15	No	No	0	9	9
57	R:R:P306	R:R:V49	3.53	No	Yes	0	9	8
58	R:R:F316	R:R:V49	5.24	Yes	Yes	0	9	8
59	R:R:F54	R:R:L50	3.65	No	Yes	0	3	7
60	R:R:A72	R:R:L50	4.73	No	Yes	0	8	7
61	R:R:L50	R:R:V73	5.96	Yes	No	0	7	5
62	R:R:R55	R:R:W51	21.99	No	No	0	6	3
63	R:R:F316	R:R:T52	6.49	Yes	No	7	9	7
64	R:R:C320	R:R:T52	6.76	No	No	7	6	7
65	R:R:R141	R:R:S63	3.95	Yes	No	0	7	6
66	R:R:G146	R:R:I66	7.05	No	No	0	7	5
67	R:R:F67	R:R:G122	4.52	No	No	0	7	6
68	R:R:F67	R:R:L123	4.87	No	No	0	7	8
69	R:R:A149	R:R:F67	4.16	No	No	0	5	7
70	R:R:A310	R:R:I68	6.5	No	No	0	6	8
71	R:R:S70	R:R:T150	4.8	No	No	0	9	6
72	R:R:C119	R:R:L71	4.76	No	Yes	0	7	9
73	R:R:L120	R:R:L71	4.15	No	Yes	8	8	9
74	R:R:L71	R:R:N305	9.61	Yes	No	8	9	9
75	R:R:D75	R:R:S302	7.36	No	No	0	9	8
76	R:R:N112	R:R:T77	8.77	No	No	0	8	7
77	R:R:F78	R:R:I109	5.02	Yes	Yes	1	6	6
78	R:R:F78	R:R:N112	3.62	Yes	No	0	6	8
79	R:R:F78	R:R:M113	4.98	Yes	No	1	6	7
80	R:R:F78	R:R:Y299	22.69	Yes	Yes	1	6	7
81	R:R:F78	R:R:S302	5.28	Yes	No	0	6	8
82	R:R:S105	R:R:T81	7.99	No	No	0	5	7
83	R:R:L108	R:R:T81	4.42	No	No	0	4	7
84	R:R:L82	R:R:Y299	9.38	No	Yes	0	7	7
85	R:R:L84	R:R:W95	6.83	No	Yes	1	6	8
86	R:R:F97	R:R:L84	8.53	Yes	No	1	6	6
87	R:R:L84	S:S:F101	3.65	No	Yes	1	6	5
88	R:R:W85	R:R:Y88	5.79	Yes	Yes	1	6	5
89	R:R:S105	R:R:W85	11.12	No	Yes	0	5	6
90	R:R:S106	R:R:W85	7.41	No	Yes	1	5	6
91	R:R:R168	R:R:W85	4	Yes	Yes	1	5	6
92	R:R:C181	R:R:W85	6.53	Yes	Yes	1	9	6
93	R:R:P96	R:R:T87	5.25	No	No	0	4	4
94	R:R:F97	R:R:T87	12.97	Yes	No	0	6	4
95	R:R:Y88	R:R:Y93	6.95	Yes	No	0	5	4
96	R:R:W95	R:R:Y88	5.79	Yes	Yes	1	8	5
97	R:R:C181	R:R:Y88	4.03	Yes	Yes	1	9	5
98	R:R:D94	R:R:R91	15.48	No	No	0	4	3
99	R:R:P96	R:R:R91	5.76	No	No	0	4	3
100	R:R:L173	R:R:Y93	4.69	Yes	No	0	3	4
101	R:R:D94	R:R:K178	9.68	No	Yes	0	4	2
102	R:R:C102	R:R:W95	6.53	No	Yes	1	9	8
103	R:R:V179	R:R:W95	3.68	No	Yes	0	5	8
104	R:R:C181	R:R:W95	5.22	Yes	Yes	1	9	8
105	R:R:F97	S:S:F100	11.79	Yes	No	1	6	1
106	R:R:F97	S:S:F101	7.5	Yes	Yes	1	6	5
107	R:R:F100	R:R:F101	10.72	No	Yes	0	1	5
108	R:R:F100	R:R:K103	4.96	No	No	0	1	7
109	R:R:F101	R:R:L104	3.65	Yes	No	0	5	5
110	R:R:F101	S:S:L84	4.87	Yes	No	0	5	6
111	R:R:F101	S:S:F101	12.86	Yes	Yes	0	5	5
112	R:R:C102	R:R:C181	7.28	No	Yes	1	9	9
113	R:R:K103	R:R:M165	5.76	No	No	0	7	5
114	R:R:L104	R:R:L108	4.15	No	No	0	5	4
115	R:R:R168	R:R:S106	11.86	Yes	No	1	5	5
116	R:R:V111	R:R:Y107	8.83	Yes	No	0	4	5
117	R:R:M165	R:R:Y107	7.18	No	No	0	5	5
118	R:R:I109	R:R:Y299	4.84	Yes	Yes	1	6	7
119	R:R:F110	R:R:M113	7.46	Yes	No	1	5	7
120	R:R:F110	R:R:Y114	5.16	Yes	Yes	1	5	6
121	R:R:F110	R:R:V164	9.18	Yes	No	0	5	4
122	R:R:N112	R:R:V111	4.43	No	Yes	0	8	4
123	R:R:M113	R:R:Y114	8.38	No	Yes	1	7	6
124	R:R:F118	R:R:Y114	5.16	Yes	Yes	0	5	6
125	R:R:L160	R:R:Y114	19.93	No	Yes	1	4	6
126	R:R:V208	R:R:Y114	7.57	No	Yes	1	5	6
127	R:R:A115	R:R:W154	7.78	No	No	0	7	9
128	R:R:F118	R:R:V117	3.93	Yes	Yes	0	5	7
129	R:R:P213	R:R:V117	3.53	Yes	Yes	0	9	7
130	R:R:F257	R:R:V117	3.93	Yes	Yes	4	8	7
131	R:R:V117	R:R:W261	3.68	Yes	Yes	4	7	9
132	R:R:F118	R:R:L153	4.87	Yes	Yes	0	5	6
133	R:R:C119	R:R:L153	4.76	No	Yes	0	7	6
134	R:R:L120	R:R:N305	6.87	No	No	8	8	9
135	R:R:G122	R:R:T121	3.64	No	No	0	6	7
136	R:R:P213	R:R:T121	3.5	Yes	No	0	9	7
137	R:R:M217	R:R:T121	6.02	No	No	0	8	7
138	R:R:L123	R:R:R127	3.64	No	No	3	8	9
139	R:R:L123	R:R:Y309	12.89	No	Yes	3	8	9
140	R:R:S124	R:R:Y221	5.09	No	Yes	0	9	8
141	R:R:F125	R:R:Y128	4.13	No	Yes	0	6	8
142	R:R:F125	R:R:L129	10.96	No	Yes	0	6	5
143	R:R:F125	R:R:R143	6.41	No	No	0	6	3
144	R:R:D126	R:R:R141	16.68	No	Yes	0	8	7
145	R:R:R127	R:R:Y221	9.26	No	Yes	3	9	8
146	R:R:R127	R:R:Y309	10.29	No	Yes	3	9	9
147	R:R:V132	R:R:Y128	6.31	No	Yes	0	7	8
148	R:R:C220	R:R:Y128	6.72	No	Yes	0	6	8
149	R:R:F223	R:R:Y128	4.13	No	Yes	0	5	8
150	R:R:L129	R:R:N137	12.36	Yes	No	9	5	6
151	R:R:L129	R:R:L140	6.92	Yes	Yes	9	5	4
152	R:R:L129	R:R:R141	6.07	Yes	Yes	0	5	7
153	R:R:A130	R:R:R141	5.53	No	Yes	0	8	7
154	R:R:I131	R:R:I224	17.66	No	No	0	8	8
155	R:R:I131	R:R:T227	4.56	No	No	0	8	4
156	R:R:A136	R:R:R133	6.91	No	No	0	4	6
157	R:R:N137	R:R:R133	14.46	No	No	0	6	6
158	R:R:P134	R:R:V135	3.53	No	No	0	8	6
159	R:R:L140	R:R:N137	13.73	Yes	No	9	4	6
160	R:R:L140	R:R:R139	6.07	Yes	No	0	4	4
161	R:R:L140	R:R:R143	12.15	Yes	No	0	4	3
162	R:R:R143	R:R:V144	6.54	No	No	0	3	4
163	R:R:L153	R:R:W154	4.56	Yes	No	0	6	9
164	R:R:L160	R:R:V208	4.47	No	No	1	4	5
165	R:R:M162	R:R:P163	5.03	No	No	0	4	8
166	R:R:L167	R:R:M183	4.24	Yes	Yes	0	5	5
167	R:R:L167	R:R:V188	7.45	Yes	No	0	5	2
168	R:R:C181	R:R:R168	9.75	Yes	Yes	1	9	5
169	R:R:M183	R:R:R168	7.44	Yes	Yes	1	5	5
170	R:R:T169	R:R:Y182	13.73	No	No	0	4	4
171	R:R:G171	R:R:T170	3.64	No	No	0	1	5
172	R:R:G171	R:R:V179	5.52	No	No	0	1	5
173	R:R:E174	R:R:L173	6.63	No	Yes	0	2	3
174	R:R:K178	R:R:L173	7.05	Yes	Yes	0	2	3
175	R:R:L173	R:R:Q180	11.98	Yes	No	0	3	2
176	R:R:T176	R:R:T177	6.28	No	No	0	3	5
177	R:R:K178	R:R:T177	6.01	Yes	No	0	2	5
178	R:R:Q180	R:R:Y182	13.53	No	No	0	2	4
179	R:R:M183	R:R:Y185	14.37	Yes	Yes	0	5	5
180	R:R:D184	R:R:M187	11.09	No	No	0	3	2
181	R:R:W197	R:R:Y185	7.72	No	Yes	0	2	5
182	R:R:E198	R:R:Y185	8.98	No	Yes	0	4	5
183	R:R:S186	R:R:V191	4.85	No	No	0	5	2
184	R:R:E194	R:R:S186	7.19	No	No	0	6	5
185	R:R:A189	R:R:W197	9.08	No	No	0	1	2
186	R:R:S193	R:R:W195	16.06	Yes	No	0	4	2
187	R:R:E194	R:R:W195	7.63	No	No	0	6	2
188	R:R:L201	R:R:W197	13.67	No	No	0	4	2
189	R:R:E198	R:R:M272	4.06	No	No	0	4	5
190	R:R:M272	R:R:V199	9.13	No	No	0	5	3
191	R:R:G202	R:R:S205	3.71	No	No	0	5	4
192	R:R:H265	R:R:T206	6.85	Yes	No	0	8	5
193	R:R:G209	R:R:P213	4.06	No	Yes	0	5	9
194	R:R:F210	R:R:F257	5.36	Yes	Yes	4	8	8
195	R:R:F210	R:R:W261	12.03	Yes	Yes	4	8	9
196	R:R:F210	R:R:M262	7.46	Yes	No	0	8	5
197	R:R:F210	R:R:H265	13.58	Yes	Yes	4	8	8
198	R:R:P213	R:R:V212	3.53	Yes	Yes	0	9	6
199	R:R:F214	R:R:F257	9.65	No	Yes	0	6	8
200	R:R:C220	R:R:Y221	8.06	No	Yes	0	6	8
201	R:R:I250	R:R:Y221	6.04	No	Yes	0	7	8
202	R:R:L253	R:R:Y221	3.52	No	Yes	3	7	8
203	R:R:V254	R:R:Y221	5.05	No	Yes	0	7	8
204	R:R:Y221	R:R:Y309	7.94	Yes	Yes	3	8	9
205	R:R:F223	R:R:Q226	7.03	No	No	0	5	3
206	R:R:H231	R:R:T227	6.85	No	No	0	5	4
207	R:R:F232	R:R:I228	11.3	Yes	No	0	4	8
208	R:R:I228	R:R:L247	4.28	No	No	0	8	6
209	R:R:F232	R:R:K242	3.72	Yes	Yes	0	4	5
210	R:R:F232	R:R:L246	3.65	Yes	No	0	4	7
211	R:R:E235	R:R:R233	16.28	No	No	0	4	4
212	R:R:L240	R:R:R233	3.64	No	No	0	4	4
213	R:R:R233	R:R:R243	17.06	No	No	0	4	6
214	R:R:E235	R:R:R236	8.14	No	No	0	4	2
215	R:R:E238	R:R:K242	12.15	No	Yes	0	4	5
216	R:R:K242	R:R:R241	7.43	Yes	No	0	5	4
217	R:R:R241	R:R:R245	14.93	No	No	0	4	7
218	R:R:I249	R:R:L253	4.28	No	No	0	7	7
219	R:R:F312	R:R:I249	21.35	No	No	0	6	7
220	R:R:L308	R:R:V252	4.47	No	No	0	8	5
221	R:R:L253	R:R:Y309	10.55	No	Yes	3	7	9
222	R:R:N301	R:R:T256	8.77	No	No	0	9	6
223	R:R:L308	R:R:T256	4.42	No	No	0	8	6
224	R:R:F257	R:R:W261	4.01	Yes	Yes	4	8	9
225	R:R:C260	R:R:W261	3.92	No	Yes	0	7	9
226	R:R:C260	R:R:N301	11.02	No	No	0	7	9
227	R:R:H265	R:R:W261	7.41	Yes	Yes	4	8	9
228	R:R:I297	R:R:P263	5.08	No	No	0	6	9
229	R:R:K268	R:R:Y264	20.3	No	Yes	0	5	6
230	R:R:F291	R:R:Y264	5.16	No	Yes	0	4	6
231	R:R:T295	R:R:Y264	3.75	No	Yes	1	5	6
232	R:R:S298	R:R:Y264	5.09	No	Yes	0	7	6
233	R:R:H265	R:R:K268	19.65	Yes	No	0	8	5
234	R:R:L266	R:R:T269	4.42	No	No	0	6	6
235	R:R:L287	R:R:Y271	4.69	Yes	Yes	0	4	4
236	R:R:M288	R:R:Y271	10.78	No	Yes	0	4	4
237	R:R:L273	R:R:W279	6.83	No	Yes	0	4	1
238	R:R:G274	R:R:W279	4.22	No	Yes	0	3	1
239	R:R:L277	R:R:W279	18.22	No	Yes	0	1	1
240	R:R:F283	R:R:W279	13.03	No	Yes	0	3	1
241	R:R:F283	R:R:L287	6.09	No	Yes	0	3	4
242	R:R:D284	R:R:L285	4.07	No	No	0	4	3
243	R:R:F286	R:R:I290	12.56	No	No	0	1	4
244	R:R:S298	R:R:Y299	5.09	No	Yes	0	7	7
245	R:R:L304	R:R:N301	9.61	No	No	0	6	9
246	R:R:F311	R:R:R317	13.9	No	No	0	6	8
247	R:R:C320	R:R:F311	5.59	No	No	0	6	6
248	R:R:D313	R:R:P314	6.44	No	No	0	8	5
249	R:R:D313	R:R:F316	3.58	No	Yes	0	8	9
250	R:R:P314	R:R:R317	4.32	No	No	0	5	8
251	R:R:C320	R:R:F316	5.59	No	Yes	7	6	9
252	S:S:A29	S:S:P32	3.74	No	No	0	3	5
253	S:S:L30	S:S:Y293	7.03	No	No	0	5	5
254	S:S:I31	S:S:P32	5.08	Yes	No	0	6	5
255	S:S:I31	S:S:P292	5.08	Yes	No	0	6	4
256	S:S:I31	S:S:Y293	6.04	Yes	No	0	6	5
257	S:S:C296	S:S:I31	6.55	Yes	Yes	0	5	6
258	S:S:P32	S:S:T89	5.25	No	No	0	5	5
259	S:S:C296	S:S:I34	9.82	Yes	No	0	5	5
260	S:S:L82	S:S:Y35	4.69	Yes	Yes	0	7	7
261	S:S:T89	S:S:Y35	3.75	No	Yes	0	5	7
262	S:S:C296	S:S:Y35	4.03	Yes	Yes	0	5	7
263	S:S:Y299	S:S:Y35	7.94	Yes	Yes	0	7	7
264	S:S:F39	S:S:L40	3.65	Yes	No	0	6	5
265	S:S:F39	S:S:T43	9.08	Yes	No	10	6	5
266	S:S:F39	S:S:V79	3.93	Yes	No	10	6	6
267	S:S:F39	S:S:L82	3.65	Yes	Yes	0	6	7
268	S:S:F39	S:S:P83	14.45	Yes	No	0	6	9
269	S:S:T43	S:S:V79	9.52	No	No	10	5	6
270	S:S:G45	S:S:T44	3.64	No	No	0	8	4
271	S:S:G45	S:S:P306	4.06	No	Yes	0	8	9
272	S:S:D75	S:S:N46	13.46	No	No	0	9	9
273	S:S:N46	S:S:P306	16.29	No	Yes	0	9	9
274	S:S:P306	S:S:V49	3.53	Yes	No	0	9	8
275	S:S:V49	S:S:Y309	3.79	No	Yes	0	8	9
276	S:S:F54	S:S:L50	4.87	No	Yes	0	3	7
277	S:S:T52	S:S:W51	6.06	No	No	11	7	3
278	S:S:R55	S:S:W51	17.99	No	No	11	6	3
279	S:S:R55	S:S:T52	10.35	No	No	11	6	7
280	S:S:I68	S:S:V53	4.61	No	No	0	8	6
281	S:S:D126	S:S:S63	7.36	No	No	5	8	6
282	S:S:R141	S:S:S63	15.81	No	No	5	7	6
283	S:S:I66	S:S:T150	7.6	No	No	0	5	6
284	S:S:F67	S:S:G122	4.52	Yes	No	0	7	6
285	S:S:F67	S:S:L123	10.96	Yes	No	0	7	8
286	S:S:F67	S:S:T150	5.19	Yes	No	0	7	6
287	S:S:C119	S:S:S70	5.16	No	No	0	7	9
288	S:S:C119	S:S:L71	6.35	No	No	0	7	9
289	S:S:L71	S:S:Y309	7.03	No	Yes	0	9	9
290	S:S:V73	S:S:W154	3.68	No	Yes	0	5	9
291	S:S:D75	S:S:N305	6.73	No	Yes	0	9	9
292	S:S:F78	S:S:L82	3.65	Yes	Yes	0	6	7
293	S:S:F78	S:S:I109	7.54	Yes	No	2	6	6
294	S:S:F78	S:S:N112	19.33	Yes	No	0	6	8
295	S:S:F78	S:S:Y299	15.47	Yes	Yes	2	6	7
296	S:S:F78	S:S:S302	11.89	Yes	No	0	6	8
297	S:S:T81	S:S:W85	4.85	No	Yes	0	7	6
298	S:S:L84	S:S:W95	5.69	No	Yes	2	6	8
299	S:S:F97	S:S:L84	7.31	Yes	No	2	6	6
300	S:S:W85	S:S:Y88	14.47	Yes	No	2	6	5
301	S:S:W85	S:S:W95	16.87	Yes	Yes	2	6	8
302	S:S:S105	S:S:W85	11.12	No	Yes	2	5	6
303	S:S:I109	S:S:W85	9.4	No	Yes	2	6	6
304	S:S:R168	S:S:W85	10	No	Yes	0	5	6
305	S:S:F97	S:S:T87	3.89	Yes	No	0	6	4
306	S:S:Y88	S:S:Y93	11.91	No	No	0	5	4
307	S:S:W95	S:S:Y88	10.61	Yes	No	2	8	5
308	S:S:T89	S:S:Y93	4.99	No	No	0	5	4
309	S:S:R91	S:S:Y90	5.14	No	No	0	3	3
310	S:S:K178	S:S:R91	7.43	Yes	No	0	2	3
311	S:S:D92	S:S:K178	5.53	No	Yes	0	6	2
312	S:S:D94	S:S:K178	16.59	No	Yes	0	4	2
313	S:S:F97	S:S:W95	14.03	Yes	Yes	2	6	8
314	S:S:C102	S:S:W95	10.45	No	Yes	0	9	8
315	S:S:S105	S:S:W95	7.41	No	Yes	2	5	8
316	S:S:F97	S:S:P96	8.67	Yes	No	0	6	4
317	S:S:T170	S:S:T99	7.85	Yes	No	0	5	3
318	S:S:F100	S:S:F101	8.57	No	Yes	1	1	5
319	S:S:C102	S:S:C181	7.28	No	No	0	9	9
320	S:S:K103	S:S:M165	5.76	No	No	0	7	5
321	S:S:K103	S:S:T169	4.5	No	No	0	7	4
322	S:S:S106	S:S:V164	4.85	No	No	0	5	4
323	S:S:R168	S:S:S106	10.54	No	No	0	5	5
324	S:S:L108	S:S:Y107	3.52	No	Yes	0	4	5
325	S:S:V111	S:S:Y107	8.83	No	Yes	0	4	5
326	S:S:A158	S:S:Y107	4	No	Yes	0	4	5
327	S:S:M165	S:S:Y107	3.59	No	Yes	0	5	5
328	S:S:I109	S:S:Y299	7.25	No	Yes	2	6	7
329	S:S:F110	S:S:Y114	6.19	No	Yes	14	5	6
330	S:S:F110	S:S:V164	18.35	No	No	0	5	4
331	S:S:F110	S:S:S205	3.96	No	No	14	5	4
332	S:S:V111	S:S:W154	3.68	No	Yes	0	4	9
333	S:S:M113	S:S:Y114	4.79	No	Yes	0	7	6
334	S:S:M113	S:S:W261	10.47	No	Yes	0	7	9
335	S:S:F118	S:S:Y114	9.28	No	Yes	0	5	6
336	S:S:L160	S:S:Y114	9.38	No	Yes	0	4	6
337	S:S:S205	S:S:Y114	5.09	No	Yes	14	4	6
338	S:S:V208	S:S:Y114	3.79	No	Yes	0	5	6
339	S:S:A115	S:S:W154	7.78	No	Yes	0	7	9
340	S:S:F257	S:S:S116	7.93	Yes	No	0	8	9
341	S:S:F118	S:S:V117	5.24	No	No	0	5	7
342	S:S:P213	S:S:V117	5.3	No	No	0	9	7
343	S:S:F118	S:S:L153	3.65	No	No	0	5	6
344	S:S:C119	S:S:L153	6.35	No	No	0	7	6
345	S:S:L120	S:S:M217	7.07	No	Yes	0	8	8
346	S:S:L120	S:S:L253	4.15	No	No	0	8	7
347	S:S:F257	S:S:L120	3.65	Yes	No	0	8	8
348	S:S:G122	S:S:T121	3.64	No	No	12	6	7
349	S:S:F125	S:S:T121	5.19	Yes	No	12	6	7
350	S:S:M217	S:S:T121	6.02	Yes	No	0	8	7
351	S:S:F125	S:S:G122	6.02	Yes	No	12	6	6
352	S:S:L123	S:S:R127	3.64	No	No	13	8	9
353	S:S:I250	S:S:L123	5.71	No	No	13	7	8
354	S:S:M217	S:S:S124	7.67	Yes	No	0	8	9
355	S:S:F125	S:S:Y128	4.13	Yes	Yes	0	6	8
356	S:S:F125	S:S:I216	3.77	Yes	No	0	6	6
357	S:S:D126	S:S:N137	12.12	No	Yes	5	8	6
358	S:S:D126	S:S:R141	13.1	No	No	5	8	7
359	S:S:L246	S:S:R127	8.5	No	No	0	7	9
360	S:S:I250	S:S:R127	18.79	No	No	13	7	9
361	S:S:C220	S:S:Y128	10.75	No	Yes	0	6	8
362	S:S:F223	S:S:Y128	4.13	No	Yes	0	5	8
363	S:S:L129	S:S:R133	4.86	No	Yes	0	5	6
364	S:S:L129	S:S:L140	4.15	No	No	0	5	4
365	S:S:A130	S:S:N137	6.25	No	Yes	0	8	6
366	S:S:I131	S:S:I224	7.36	No	Yes	0	8	8
367	S:S:I131	S:S:R243	10.02	No	Yes	0	8	6
368	S:S:R133	S:S:V132	11.77	Yes	No	0	6	7
369	S:S:A136	S:S:R133	5.53	No	Yes	0	4	6
370	S:S:A136	S:S:R139	6.91	No	No	0	4	4
371	S:S:N137	S:S:R141	10.85	Yes	No	5	6	7
372	S:S:R139	S:S:R143	6.4	No	No	0	4	3
373	S:S:G146	S:S:S145	3.71	No	No	0	7	4
374	S:S:M162	S:S:P163	5.03	No	No	0	4	8
375	S:S:L167	S:S:M183	5.65	No	No	0	5	5
376	S:S:L167	S:S:W197	4.56	No	Yes	0	5	2
377	S:S:C181	S:S:R168	12.54	No	No	0	9	5
378	S:S:D184	S:S:T169	4.34	No	No	0	3	4
379	S:S:T170	S:S:V179	4.76	Yes	No	0	5	5
380	S:S:C181	S:S:T170	5.07	No	Yes	0	9	5
381	S:S:D172	S:S:V179	4.38	No	No	0	1	5
382	S:S:E174	S:S:L173	3.98	No	No	0	2	3
383	S:S:L173	S:S:Q180	9.32	No	No	0	3	2
384	S:S:L173	S:S:Y182	17.58	No	No	0	3	4
385	S:S:K178	S:S:Q180	4.07	Yes	No	0	2	2
386	S:S:D184	S:S:Y182	14.94	No	No	0	3	4
387	S:S:M183	S:S:Y185	13.17	No	Yes	0	5	5
388	S:S:D184	S:S:M187	15.25	No	No	0	3	2
389	S:S:E194	S:S:Y185	8.98	No	Yes	0	6	5
390	S:S:W197	S:S:Y185	6.75	Yes	Yes	0	2	5
391	S:S:E198	S:S:Y185	26.93	No	Yes	0	4	5
392	S:S:E194	S:S:S186	11.5	No	No	0	6	5
393	S:S:V188	S:S:W197	8.58	No	Yes	0	2	2
394	S:S:S192	S:S:T190	4.8	No	No	0	2	1
395	S:S:S193	S:S:T190	4.8	No	No	0	4	1
396	S:S:E198	S:S:W195	15.27	No	Yes	0	4	2
397	S:S:W195	S:S:Y271	3.86	Yes	No	0	2	4
398	S:S:S275	S:S:W195	8.65	No	Yes	16	4	2
399	S:S:L276	S:S:W195	4.56	No	Yes	16	1	2
400	S:S:L201	S:S:W197	11.39	No	Yes	0	4	2
401	S:S:M272	S:S:V199	7.61	No	No	0	5	3
402	S:S:M272	S:S:V203	4.56	No	No	0	5	4
403	S:S:H265	S:S:T206	5.48	No	No	0	8	5
404	S:S:K268	S:S:T206	4.5	No	No	0	5	5
405	S:S:T206	S:S:T269	4.71	No	No	0	5	6
406	S:S:F210	S:S:F214	20.36	No	No	0	8	6
407	S:S:F210	S:S:M262	9.95	No	No	0	8	5
408	S:S:F210	S:S:H265	19.23	No	No	0	8	8
409	S:S:P213	S:S:V212	3.53	No	No	0	9	6
410	S:S:F214	S:S:F257	7.5	No	Yes	0	6	8
411	S:S:I216	S:S:T219	4.56	No	No	0	6	4
412	S:S:M217	S:S:Y221	9.58	Yes	No	0	8	8
413	S:S:V254	S:S:Y221	7.57	No	No	0	7	8
414	S:S:I224	S:S:L247	4.28	Yes	No	0	8	6
415	S:S:H231	S:S:T227	8.21	No	No	0	5	4
416	S:S:H231	S:S:K234	10.48	No	No	0	5	3
417	S:S:K234	S:S:L240	16.92	No	No	15	3	4
418	S:S:K234	S:S:R243	3.71	No	Yes	15	3	6
419	S:S:E238	S:S:R236	16.28	No	No	0	4	2
420	S:S:G239	S:S:R236	4.5	No	No	0	4	2
421	S:S:I237	S:S:R244	5.01	No	Yes	0	3	5
422	S:S:E238	S:S:R241	15.12	No	No	0	4	4
423	S:S:L240	S:S:R243	9.72	No	Yes	15	4	6
424	S:S:R241	S:S:R245	14.93	No	No	0	4	7
425	S:S:R244	S:S:R245	6.4	Yes	No	0	5	7
426	S:S:R244	S:S:S248	14.5	Yes	No	0	5	6
427	S:S:L308	S:S:V252	7.45	No	No	0	8	5
428	S:S:L253	S:S:N305	5.49	No	Yes	2	7	9
429	S:S:L253	S:S:Y309	9.38	No	Yes	2	7	9
430	S:S:L308	S:S:T256	4.42	No	No	0	8	6
431	S:S:F257	S:S:W261	21.05	Yes	Yes	2	8	9
432	S:S:F257	S:S:N301	12.08	Yes	No	2	8	9
433	S:S:C260	S:S:W261	5.22	No	Yes	0	7	9
434	S:S:W261	S:S:Y264	4.82	Yes	Yes	2	9	6
435	S:S:S298	S:S:W261	13.59	No	Yes	2	7	9
436	S:S:W261	S:S:Y299	5.79	Yes	Yes	2	9	7
437	S:S:N301	S:S:W261	4.52	No	Yes	2	9	9
438	S:S:L266	S:S:M262	7.07	No	No	0	6	5
439	S:S:C294	S:S:P263	3.77	No	No	0	6	9
440	S:S:H265	S:S:Y264	9.8	No	Yes	0	8	6
441	S:S:K268	S:S:Y264	11.94	No	Yes	2	5	6
442	S:S:F291	S:S:Y264	7.22	Yes	Yes	2	4	6
443	S:S:T295	S:S:Y264	6.24	No	Yes	2	5	6
444	S:S:S298	S:S:Y264	7.63	No	Yes	2	7	6
445	S:S:L287	S:S:V267	4.47	No	No	0	4	4
446	S:S:F291	S:S:V267	7.87	Yes	No	0	4	4
447	S:S:F291	S:S:K268	7.44	Yes	No	2	4	5
448	S:S:F283	S:S:L270	6.09	No	No	0	3	5
449	S:S:L273	S:S:M272	5.65	No	No	0	4	5
450	S:S:L273	S:S:W279	4.56	No	No	0	4	1
451	S:S:G274	S:S:W279	5.63	No	No	0	3	1
452	S:S:D284	S:S:G274	5.03	No	No	0	4	3
453	S:S:L276	S:S:S275	7.51	No	No	16	1	4
454	S:S:L277	S:S:W279	11.39	No	No	0	1	1
455	S:S:D282	S:S:P280	6.44	No	No	0	2	4
456	S:S:F286	S:S:L287	3.65	No	No	0	1	4
457	S:S:F286	S:S:I290	12.56	No	No	0	1	4
458	S:S:C294	S:S:I290	4.91	No	No	0	6	4
459	S:S:F291	S:S:T295	7.78	Yes	No	2	4	5
460	S:S:T295	S:S:Y299	4.99	No	Yes	2	5	7
461	S:S:S298	S:S:Y299	6.36	No	Yes	2	7	7
462	S:S:L304	S:S:V300	4.47	No	No	0	6	5
463	S:S:N301	S:S:N305	13.62	No	Yes	2	9	9
464	S:S:N305	S:S:P306	4.89	Yes	Yes	0	9	9
465	S:S:N305	S:S:Y309	5.81	Yes	Yes	2	9	9
466	S:S:F307	S:S:P306	4.33	No	Yes	0	6	9
467	R:R:G239	R:R:K234	3.49	No	No	0	4	3
468	R:R:C294	R:R:V267	3.42	No	No	0	6	4
469	S:S:C303	S:S:V38	3.42	No	No	0	7	7
470	S:S:G47	S:S:L76	3.42	No	No	0	3	7
471	S:S:L153	S:S:W154	3.42	No	Yes	0	6	9
472	S:S:A189	S:S:S193	3.42	No	No	0	1	4
473	R:R:A72	R:R:V49	3.39	No	Yes	0	8	8
474	R:R:A161	R:R:V111	3.39	No	Yes	0	7	4
475	S:S:A69	S:S:V53	3.39	No	No	0	5	6
476	S:S:H231	S:S:R233	3.39	No	No	0	5	4
477	R:R:M36	R:R:P83	3.35	No	No	0	3	9
478	R:R:D172	R:R:G171	3.35	No	No	0	1	1
479	R:R:C294	R:R:I297	3.27	No	No	0	6	6
480	R:R:S192	R:R:S193	3.26	No	Yes	0	2	4
481	S:S:F283	S:S:F286	3.22	No	No	0	3	1
482	S:S:V300	S:S:V38	3.21	No	No	0	5	7
483	R:R:T227	R:R:V132	3.17	No	No	0	4	7
484	R:R:T206	R:R:V203	3.17	No	No	0	5	4
485	S:S:C303	S:S:L41	3.17	No	No	0	7	5
486	S:S:T227	S:S:V132	3.17	No	No	0	4	7
487	S:S:T207	S:S:V211	3.17	Yes	No	0	3	4
488	R:R:A225	R:R:L247	3.15	No	No	0	5	6
489	S:S:A72	S:S:L50	3.15	No	Yes	0	8	7
490	R:R:T170	R:R:T99	3.14	No	No	0	5	3
491	L:L:R4	R:R:Y182	3.09	No	No	0	0	4
492	R:R:I216	R:R:V212	3.07	No	Yes	0	6	6
493	R:R:M272	R:R:S275	3.07	No	No	0	5	4
494	S:S:M187	S:S:S186	3.07	No	No	0	2	5
495	R:R:I66	R:R:T150	3.04	No	No	0	5	6
496	S:S:M162	S:S:V166	3.04	No	No	0	4	4
497	R:R:F307	R:R:G45	3.01	No	No	0	6	8
498	R:R:F101	R:R:G98	3.01	Yes	No	0	5	8
499	R:R:L71	R:R:S116	3	Yes	No	0	9	9
500	R:R:L201	R:R:S204	3	No	No	0	4	4
501	S:S:K178	S:S:T176	3	Yes	No	0	2	3
502	R:R:L76	R:R:V80	2.98	No	No	0	7	4
503	R:R:L167	R:R:V166	2.98	Yes	No	0	5	4
504	R:R:L287	R:R:V267	2.98	Yes	No	0	4	4
505	S:S:L82	S:S:V38	2.98	Yes	No	0	7	7
506	S:S:L50	S:S:V73	2.98	Yes	No	0	7	5
507	S:S:L156	S:S:V152	2.98	No	No	0	4	2
508	S:S:L276	S:S:V199	2.98	No	No	0	1	3
509	S:S:L247	S:S:V251	2.98	No	No	0	6	3
510	R:R:L153	R:R:T150	2.95	Yes	No	0	6	6
511	S:S:L304	S:S:T256	2.95	No	No	0	6	6
512	R:R:I224	R:R:I228	2.94	No	No	0	8	8
513	S:S:I224	S:S:I228	2.94	Yes	No	0	8	8
514	R:R:D75	R:R:V79	2.92	No	No	0	9	6
515	R:R:F307	R:R:P306	2.89	No	No	0	6	9
516	S:S:E194	S:S:V191	2.85	No	No	0	6	2
517	R:R:L167	R:R:M187	2.83	Yes	No	0	5	2
518	S:S:L40	S:S:M36	2.83	No	No	0	5	3
519	R:R:A258	R:R:F214	2.77	No	No	0	5	6
520	R:R:L266	R:R:L270	2.77	No	No	0	6	5
521	S:S:L50	S:S:L76	2.77	Yes	No	0	7	7
522	S:S:A69	S:S:F54	2.77	No	No	0	5	3
523	S:S:A149	S:S:F67	2.77	No	Yes	0	5	7
524	S:S:A258	S:S:F214	2.77	No	No	0	5	6
525	S:S:L129	S:S:N137	2.75	No	Yes	0	5	6
526	S:S:E235	S:S:I228	2.73	No	No	0	4	8
527	R:R:C296	R:R:Y35	2.69	No	Yes	0	5	7
528	S:S:A161	S:S:Y107	2.67	No	Yes	0	7	5
529	R:R:F316	R:R:V53	2.62	Yes	No	0	9	6
530	R:R:A74	R:R:W154	2.59	No	No	0	8	9
531	S:S:A74	S:S:W154	2.59	No	Yes	0	8	9
532	R:R:F39	R:R:L40	2.44	No	No	0	6	5
533	R:R:F311	R:R:L48	2.44	No	No	0	6	5
534	R:R:F118	R:R:L156	2.44	Yes	No	0	5	4
535	R:R:F286	R:R:L287	2.44	No	Yes	0	1	4
536	S:S:F100	S:S:L104	2.44	No	No	0	1	5
537	S:S:I224	S:S:Y128	2.42	Yes	Yes	0	8	8
538	S:S:M288	S:S:Y271	2.39	No	No	0	4	4
539	S:S:L218	S:S:Y221	2.34	No	No	0	4	8
540	R:R:D284	R:R:Y271	2.3	No	Yes	0	4	4
541	S:S:L48	S:S:W51	2.28	No	No	0	5	3
542	R:R:E194	R:R:Y185	2.24	No	Yes	0	6	5
543	R:R:F232	R:R:R243	2.14	Yes	No	0	4	6
544	S:S:F222	S:S:F223	2.14	No	No	0	3	5
545	S:S:G209	S:S:P213	2.03	No	No	0	5	9
546	S:S:C303	S:S:G42	1.96	No	No	0	7	8
547	S:S:A149	S:S:G146	1.95	No	No	0	5	7
548	R:R:G28	R:R:S27	1.86	No	No	0	3	3
549	R:R:G146	R:R:S145	1.86	No	No	0	7	4
550	R:R:G200	R:R:V199	1.84	No	No	0	2	3
551	R:R:G200	R:R:V203	1.84	No	No	0	2	4
552	S:S:G200	S:S:V199	1.84	No	No	0	2	3
553	S:S:G171	S:S:T170	1.82	No	Yes	0	1	5
554	R:R:A115	R:R:A157	1.79	No	No	0	7	7
555	S:S:A115	S:S:A157	1.79	No	No	0	7	7
556	R:R:G239	R:R:K242	1.74	No	Yes	0	4	5
557	R:R:C303	R:R:V38	1.71	No	No	0	7	7
558	R:R:G42	R:R:L41	1.71	No	No	0	8	5
559	R:R:G47	R:R:L50	1.71	No	Yes	0	3	7
560	R:R:A64	R:R:S63	1.71	No	No	0	8	6
561	R:R:A196	R:R:S193	1.71	No	Yes	0	1	4
562	S:S:G45	S:S:L48	1.71	No	No	0	8	5
563	S:S:G202	S:S:L201	1.71	No	No	0	5	4
564	R:R:A310	R:R:V49	1.7	No	Yes	0	6	8
565	R:R:A69	R:R:V53	1.7	No	No	0	5	6
566	R:R:A158	R:R:V111	1.7	No	Yes	0	4	4
567	R:R:A138	R:R:V135	1.7	No	No	0	5	6
568	S:S:A149	S:S:V144	1.7	No	No	0	5	4
569	R:R:C220	R:R:T219	1.69	No	No	0	6	4
570	S:S:A74	S:S:T77	1.68	No	No	0	8	7
571	S:S:L201	S:S:P163	1.64	No	No	0	4	8
572	S:S:C260	S:S:I297	1.64	No	No	0	7	6
573	S:S:C296	S:S:I297	1.64	Yes	No	0	5	6
574	R:R:S145	R:R:V148	1.62	No	No	0	4	3
575	R:R:S248	R:R:V252	1.62	No	No	0	6	5
576	S:S:S145	S:S:V148	1.62	No	No	0	4	3
577	R:R:S193	R:R:T190	1.6	Yes	No	0	4	1
578	R:R:V211	R:R:V212	1.6	No	Yes	1	4	6
579	R:R:V251	R:R:V252	1.6	No	No	0	3	5
580	R:R:T207	R:R:V208	1.59	No	No	1	3	5
581	R:R:T207	R:R:V211	1.59	No	No	1	3	4
582	R:R:T207	R:R:V212	1.59	No	Yes	1	3	6
583	R:R:G230	R:R:H231	1.59	No	No	0	4	5
584	S:S:T81	S:S:V80	1.59	No	No	0	7	4
585	S:S:T207	S:S:V203	1.59	Yes	No	0	3	4
586	S:S:T207	S:S:V208	1.59	Yes	No	0	3	5
587	S:S:T207	S:S:V212	1.59	Yes	No	0	3	6
588	S:S:T256	S:S:V255	1.59	No	No	0	6	4
589	R:R:T206	R:R:T269	1.57	No	No	0	5	6
590	R:R:T215	R:R:T219	1.57	No	No	0	2	4
591	R:R:C281	R:R:D282	1.56	No	No	0	8	2
592	R:R:A64	R:R:D65	1.54	No	No	0	8	8
593	S:S:A64	S:S:D65	1.54	No	No	0	8	8
594	S:S:A229	S:S:Q226	1.52	No	No	0	4	3
595	R:R:L276	R:R:S275	1.5	No	No	0	1	4
596	R:R:L156	R:R:V152	1.49	No	No	0	4	2
597	R:R:L159	R:R:V155	1.49	No	No	0	4	4
598	R:R:L218	R:R:V254	1.49	No	No	0	4	7
599	S:S:L259	S:S:V255	1.49	No	No	0	5	4
600	R:R:P134	R:R:R133	1.44	No	No	0	8	6
601	S:S:P134	S:S:R133	1.44	No	Yes	0	8	6
602	S:S:P134	S:S:R243	1.44	No	Yes	0	8	6
603	S:S:F283	S:S:P280	1.44	No	No	0	3	4
604	R:R:L159	R:R:M162	1.41	No	No	0	4	4
605	S:S:L37	S:S:M36	1.41	No	No	0	5	3
606	S:S:D65	S:S:I68	1.4	No	No	0	8	8
607	S:S:A229	S:S:F232	1.39	No	No	0	4	4
608	R:R:D92	R:R:K178	1.38	No	Yes	0	6	2
609	R:R:A229	R:R:R243	1.38	No	No	0	4	6
610	R:R:P280	R:R:W279	1.35	No	Yes	0	4	1
611	R:R:A29	R:R:Y90	1.33	No	No	0	3	3
612	R:R:A86	R:R:Y35	1.33	No	Yes	0	6	7
613	S:S:A86	S:S:Y35	1.33	No	Yes	0	6	7
614	R:R:R317	R:R:T321	1.29	No	No	0	8	4
615	S:S:I249	S:S:R245	1.25	No	No	0	7	7
616	S:S:L240	S:S:R244	1.21	No	Yes	0	4	5
617	S:S:I249	S:S:Y309	1.21	No	Yes	0	7	9
618	R:R:D313	R:R:R315	1.19	No	No	0	8	7
619	L:L:R2	R:R:E20	1.16	No	No	0	0	5
620	L:L:Q1	R:R:Y271	1.13	No	Yes	0	0	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:S6	5.115	4	1	0
2	L:L:P10	8.61167	6	1	0
3	L:L:M11	5.81667	6	1	0
4	L:L:P12	8.0375	4	1	0
5	L:L:F13	8.615	4	0	0
6	R:R:I31	6.7125	4	0	6
7	R:R:Y35	4.09333	6	1	7
8	R:R:V49	3.465	4	0	8
9	R:R:L50	4.0125	4	0	7
10	R:R:L71	5.38	4	8	9
11	R:R:F78	8.318	5	1	6
12	R:R:W85	9.41167	6	1	6
13	R:R:Y88	5.64	4	1	5
14	R:R:W95	5.61	5	1	8
15	R:R:F97	10.1975	4	1	6
16	R:R:F101	7.022	5	0	5
17	R:R:I109	5.25	4	1	6
18	R:R:F110	7.036	5	1	5
19	R:R:V111	4.5875	4	0	4
20	R:R:Y114	9.24	5	1	6
21	R:R:V117	3.7675	4	4	7
22	R:R:F118	4.1	4	0	5
23	R:R:Y128	5.3225	4	0	8
24	R:R:L129	9.0775	4	9	5
25	R:R:L140	9.7175	4	9	4
26	R:R:R141	8.0575	4	0	7
27	R:R:L153	4.285	4	0	6
28	R:R:L167	4.375	4	0	5
29	R:R:R168	8.52833	6	1	5
30	R:R:L173	7.5875	4	0	3
31	R:R:K178	6.03	4	0	2
32	R:R:C181	6.562	5	1	9
33	R:R:M183	8.114	5	1	5
34	R:R:Y185	8.3275	4	0	5
35	R:R:S193	5.6575	4	0	4
36	R:R:F210	9.6075	4	4	8
37	R:R:V212	2.4475	4	1	6
38	R:R:P213	3.655	4	0	9
39	R:R:Y221	6.42286	7	3	8
40	R:R:F232	5.2025	4	0	4
41	R:R:K242	6.26	4	0	5
42	R:R:F257	5.7375	4	4	8
43	R:R:W261	6.21	5	4	9
44	R:R:Y264	8.776	5	1	6
45	R:R:H265	11.8725	4	4	8
46	R:R:Y271	6.124	5	0	4
47	R:R:W279	8.73	5	0	1
48	R:R:L287	4.05	4	0	4
49	R:R:Y299	9.38833	6	1	7
50	R:R:Y309	10.4175	4	3	9
51	R:R:F316	4.704	5	7	9
52	S:S:I31	5.6875	4	0	6
53	S:S:Y35	4.348	5	0	7
54	S:S:F39	6.952	5	10	6
55	S:S:L50	3.4425	4	0	7
56	S:S:F67	5.86	4	0	7
57	S:S:F78	11.576	5	2	6
58	S:S:L82	3.7425	4	0	7
59	S:S:W85	11.1183	6	2	6
60	S:S:W95	10.8433	6	2	8
61	S:S:F97	8.475	4	2	6
62	S:S:F101	8.145	4	1	5
63	S:S:Y107	4.522	5	0	5
64	S:S:Y114	6.42	6	14	6
65	S:S:F125	4.7775	4	12	6
66	S:S:Y128	5.3575	4	0	8
67	S:S:R133	5.9	4	0	6
68	S:S:N137	7.9925	4	5	6
69	S:S:W154	4.23	5	0	9
70	S:S:T170	4.875	4	0	5
71	S:S:K178	7.324	5	0	2
72	S:S:Y185	13.9575	4	0	5
73	S:S:W195	8.085	4	16	2
74	S:S:W197	7.82	4	0	2
75	S:S:T207	1.985	4	0	3
76	S:S:M217	7.585	4	0	8
77	S:S:I224	4.25	4	0	8
78	S:S:R243	6.2225	4	15	6
79	S:S:R244	6.78	4	0	5
80	S:S:F257	10.442	5	2	8
81	S:S:W261	9.35143	7	2	9
82	S:S:Y264	7.94167	6	2	6
83	S:S:F291	7.5775	4	2	4
84	S:S:C296	5.51	4	0	5
85	S:S:Y299	7.96667	6	2	7
86	S:S:N305	7.308	5	2	9
87	S:S:P306	6.62	5	0	9
88	S:S:Y309	5.444	5	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:M11	R:R:Y264	15.8962	9.58	Yes	Yes	1	0	6
2	L:L:M11	L:L:P10	59.6053	6.71	Yes	Yes	1	0	0
3	L:L:P10	R:R:W85	65.5325	21.62	Yes	Yes	1	0	6
4	R:R:W85	R:R:Y88	23.66	5.79	Yes	Yes	1	6	5
5	R:R:C181	R:R:R168	17.9717	9.75	Yes	Yes	1	9	5
6	L:L:M11	R:R:F110	45.4903	3.73	Yes	Yes	1	0	5
7	L:L:F13	L:L:P12	17.1292	8.67	Yes	Yes	0	0	0
8	L:L:F13	R:R:F110	17.6989	9.65	Yes	Yes	0	0	5
9	R:R:F110	R:R:Y114	61.117	5.16	Yes	Yes	1	5	6
10	R:R:F118	R:R:Y114	73.637	5.16	Yes	Yes	0	5	6
11	R:R:F118	R:R:V117	64.5319	3.93	Yes	Yes	0	5	7
12	R:R:P213	R:R:V117	63.9838	3.53	Yes	Yes	0	9	7
13	R:R:P213	R:R:T121	63.1092	3.5	Yes	No	0	9	7
14	R:R:G122	R:R:T121	62.1069	3.64	No	No	0	6	7
15	R:R:F67	R:R:G122	61.605	4.52	No	No	0	7	6
16	R:R:F67	R:R:L123	60.5996	4.87	No	No	0	7	8
17	R:R:L123	R:R:R127	29.2503	3.64	No	No	3	8	9
18	R:R:R127	R:R:Y221	28.7326	9.26	No	Yes	3	9	8
19	R:R:C220	R:R:Y221	52.241	8.06	No	Yes	0	6	8
20	R:R:C220	R:R:Y128	49.077	6.72	No	Yes	0	6	8
21	R:R:F125	R:R:Y128	21.4673	4.13	No	Yes	0	6	8
22	R:R:F125	R:R:L129	16.1077	10.96	No	Yes	0	6	5
23	R:R:L123	R:R:Y309	30.8457	12.89	No	Yes	3	8	9
24	R:R:Y221	R:R:Y309	28.7319	7.94	Yes	Yes	3	8	9
25	R:R:F78	R:R:N112	18.8399	3.62	Yes	No	0	6	8
26	R:R:F78	R:R:M113	16.7544	4.98	Yes	No	1	6	7
27	R:R:S105	R:R:W85	20.3354	11.12	No	Yes	0	5	6
28	R:R:S105	R:R:T81	20.3239	7.99	No	No	0	5	7
29	R:R:L108	R:R:T81	20.3179	4.42	No	No	0	4	7
30	R:R:W95	R:R:Y88	23.9823	5.79	Yes	Yes	1	8	5
31	R:R:L84	R:R:W95	62.3041	6.83	No	Yes	1	6	8
32	R:R:L84	S:S:F101	61.1387	3.65	No	Yes	1	6	5
33	R:R:F101	S:S:F101	61.6296	12.86	Yes	Yes	0	5	5
34	R:R:F100	R:R:F101	18.6783	10.72	No	Yes	0	1	5
35	R:R:F100	R:R:K103	18.6125	4.96	No	No	0	1	7
36	R:R:L104	R:R:L108	20.3162	4.15	No	No	0	5	4
37	R:R:F101	R:R:L104	20.3279	3.65	Yes	No	0	5	5
38	R:R:F101	S:S:L84	100	4.87	Yes	No	0	5	6
39	R:R:K103	R:R:M165	18.5878	5.76	No	No	0	7	5
40	R:R:N112	R:R:V111	18.7471	4.43	No	Yes	0	8	4
41	R:R:V111	R:R:Y107	18.6214	8.83	Yes	No	0	4	5
42	R:R:V132	R:R:Y128	24.6703	6.31	No	Yes	0	7	8
43	R:R:T227	R:R:V132	23.6031	3.17	No	No	0	4	7
44	R:R:I131	R:R:T227	20.3987	4.56	No	No	0	8	4
45	R:R:I131	R:R:I224	19.3295	17.66	No	No	0	8	8
46	R:R:I224	R:R:I228	18.2599	2.94	No	No	0	8	8
47	R:R:F232	R:R:I228	15.048	11.3	Yes	No	0	4	8
48	S:S:L84	S:S:W95	98.9885	5.69	No	Yes	2	6	8
49	S:S:W85	S:S:W95	93.0237	16.87	Yes	Yes	2	6	8
50	S:S:I109	S:S:W85	69.6103	9.4	No	Yes	2	6	6
51	S:S:I109	S:S:Y299	63.2151	7.25	No	Yes	2	6	7
52	S:S:W261	S:S:Y299	53.9544	5.79	Yes	Yes	2	9	7
53	S:S:N301	S:S:W261	15.5215	4.52	No	Yes	2	9	9
54	S:S:N301	S:S:N305	15.3058	13.62	No	Yes	2	9	9
55	S:S:N305	S:S:Y309	11.1494	5.81	Yes	Yes	2	9	9
56	S:S:M113	S:S:W261	25.0108	10.47	No	Yes	0	7	9
57	S:S:M113	S:S:Y114	24.7106	4.79	No	Yes	0	7	6
58	S:S:F118	S:S:Y114	26.1441	9.28	No	Yes	0	5	6
59	S:S:F118	S:S:L153	23.8714	3.65	No	No	0	5	6
60	S:S:L153	S:S:W154	22.7688	3.42	No	Yes	0	6	9
61	S:S:R168	S:S:W85	23.7273	10	No	Yes	0	5	6
62	S:S:R168	S:S:S106	23.2987	10.54	No	No	0	5	5
63	S:S:S106	S:S:V164	23.0284	4.85	No	No	0	5	4
64	S:S:F110	S:S:V164	22.799	18.35	No	No	0	5	4
65	S:S:F110	S:S:Y114	22.3091	6.19	No	Yes	14	5	6
66	S:S:I249	S:S:Y309	10.4261	1.21	No	Yes	0	7	9
67	S:S:I249	S:S:R245	10.0855	1.25	No	No	0	7	7
68	S:S:F257	S:S:W261	12.8342	21.05	Yes	Yes	2	8	9
69	S:S:F257	S:S:L120	10.7856	3.65	Yes	No	0	8	8
70	S:S:L120	S:S:M217	10.5859	7.07	No	Yes	0	8	8
71	S:S:V111	S:S:W154	13.0907	3.68	No	Yes	0	4	9
72	S:S:V111	S:S:Y107	12.4826	8.83	No	Yes	0	4	5
73	S:S:M165	S:S:Y107	10.0511	3.59	No	Yes	0	5	5
74	S:S:V208	S:S:Y114	20.2458	3.79	No	Yes	0	5	6
75	S:S:T207	S:S:V208	19.6325	1.59	Yes	No	0	3	5
76	S:S:T207	S:S:V203	17.842	1.59	Yes	No	0	3	4
77	S:S:M272	S:S:V203	17.2317	4.56	No	No	0	5	4
78	S:S:M272	S:S:V199	13.562	7.61	No	No	0	5	3
79	S:S:L276	S:S:V199	12.3358	2.98	No	No	0	1	3
80	S:S:L276	S:S:W195	11.1018	4.56	No	Yes	16	1	2
81	R:R:C181	R:R:W85	21.2776	6.53	Yes	Yes	1	9	6
82	R:R:C181	R:R:W95	38.954	5.22	Yes	Yes	1	9	8
83	R:R:M165	R:R:Y107	18.5878	7.18	No	No	0	5	5
84	L:L:P12	R:R:R168	15.2923	11.53	Yes	Yes	1	0	5
85	R:R:M113	R:R:Y114	16.0294	8.38	No	Yes	1	7	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:R2	R:R:E174	13.96	0	No	No	0	2	0	1
L:L:L5	R:R:Y271	11.72	0	No	Yes	0	4	0	1
L:L:L5	R:R:F291	9.74	0	No	No	0	4	0	1
L:L:S6	R:R:R168	6.59	1	Yes	Yes	0	5	0	1
L:L:S6	R:R:M183	6.13	1	Yes	Yes	0	5	0	1
L:L:H7	R:R:Q180	11.13	0	No	No	0	2	0	1
L:L:K8	R:R:I31	4.36	0	No	Yes	0	6	0	1
L:L:K8	R:R:T89	9.01	0	No	No	0	5	0	1
L:L:K8	R:R:Y93	15.53	0	No	No	0	4	0	1
L:L:G9	R:R:Y35	4.35	1	No	Yes	0	7	0	1
L:L:P10	R:R:Y35	4.17	1	Yes	Yes	0	7	0	1
L:L:P10	R:R:W85	21.62	1	Yes	Yes	0	6	0	1
L:L:P10	R:R:I109	6.77	1	Yes	Yes	0	6	0	1
L:L:P10	R:R:Y299	8.34	1	Yes	Yes	0	7	0	1
L:L:M11	R:R:I109	4.37	1	Yes	Yes	0	6	0	1
L:L:M11	R:R:F110	3.73	1	Yes	Yes	0	5	0	1
L:L:M11	R:R:Y264	9.58	1	Yes	Yes	0	6	0	1
L:L:M11	R:R:T295	4.52	1	Yes	No	0	5	0	1
L:L:M11	R:R:Y299	5.99	1	Yes	Yes	0	7	0	1
L:L:P12	R:R:R168	11.53	1	Yes	Yes	0	5	0	1
L:L:P12	R:R:M183	8.39	1	Yes	Yes	0	5	0	1
L:L:F13	R:R:F110	9.65	0	Yes	Yes	0	5	0	1
L:L:F13	R:R:L201	12.18	0	Yes	No	0	4	0	1
L:L:F13	R:R:S205	3.96	0	Yes	No	0	4	0	1
R:R:I31	R:R:P32	6.77	0	Yes	No	6	5	1	2
R:R:I31	R:R:P292	8.47	0	Yes	No	6	4	1	2
R:R:I31	R:R:Y293	7.25	0	Yes	No	6	5	1	2
R:R:P32	R:R:T89	8.74	0	No	No	5	5	2	1
R:R:L82	R:R:Y35	7.03	0	No	Yes	7	7	2	1
R:R:T295	R:R:Y35	4.99	1	No	Yes	5	7	1	1
R:R:F78	R:R:I109	5.02	1	Yes	Yes	6	6	2	1
R:R:F78	R:R:M113	4.98	1	Yes	No	6	7	2	2
R:R:F78	R:R:Y299	22.69	1	Yes	Yes	6	7	2	1
R:R:L82	R:R:Y299	9.38	0	No	Yes	7	7	2	1
R:R:W85	R:R:Y88	5.79	1	Yes	Yes	6	5	1	2
R:R:S105	R:R:W85	11.12	0	No	Yes	5	6	2	1
R:R:S106	R:R:W85	7.41	1	No	Yes	5	6	2	1
R:R:R168	R:R:W85	4	1	Yes	Yes	5	6	1	1
R:R:C181	R:R:W85	6.53	1	Yes	Yes	9	6	2	1
R:R:Y88	R:R:Y93	6.95	1	Yes	No	5	4	2	1
R:R:C181	R:R:Y88	4.03	1	Yes	Yes	9	5	2	2
R:R:L173	R:R:Y93	4.69	0	Yes	No	3	4	2	1
R:R:R168	R:R:S106	11.86	1	Yes	No	5	5	1	2
R:R:I109	R:R:Y299	4.84	1	Yes	Yes	6	7	1	1
R:R:F110	R:R:M113	7.46	1	Yes	No	5	7	1	2
R:R:F110	R:R:Y114	5.16	1	Yes	Yes	5	6	1	2
R:R:F110	R:R:V164	9.18	1	Yes	No	5	4	1	2
R:R:M113	R:R:Y114	8.38	1	No	Yes	7	6	2	2
R:R:L167	R:R:M183	4.24	0	Yes	Yes	5	5	2	1
R:R:C181	R:R:R168	9.75	1	Yes	Yes	9	5	2	1
R:R:M183	R:R:R168	7.44	1	Yes	Yes	5	5	1	1
R:R:T169	R:R:Y182	13.73	0	No	No	4	4	2	1
R:R:E174	R:R:L173	6.63	0	No	Yes	2	3	1	2
R:R:L173	R:R:Q180	11.98	0	Yes	No	3	2	2	1
R:R:Q180	R:R:Y182	13.53	0	No	No	2	4	1	1
R:R:M183	R:R:Y185	14.37	1	Yes	Yes	5	5	1	2
R:R:W197	R:R:Y185	7.72	0	No	Yes	2	5	2	2
R:R:L201	R:R:W197	13.67	0	No	No	4	2	1	2
R:R:G202	R:R:S205	3.71	0	No	No	5	4	2	1
R:R:K268	R:R:Y264	20.3	0	No	Yes	5	6	2	1
R:R:F291	R:R:Y264	5.16	0	No	Yes	4	6	1	1
R:R:T295	R:R:Y264	3.75	1	No	Yes	5	6	1	1
R:R:S298	R:R:Y264	5.09	0	No	Yes	7	6	2	1
R:R:L287	R:R:Y271	4.69	0	Yes	Yes	4	4	2	1
R:R:M288	R:R:Y271	10.78	0	No	Yes	4	4	2	1
R:R:S298	R:R:Y299	5.09	0	No	Yes	7	7	2	1
L:L:R4	R:R:Y182	3.09	0	No	No	0	4	0	1
R:R:L201	R:R:S204	3	0	No	No	4	4	1	2
R:R:C296	R:R:Y35	2.69	0	No	Yes	5	7	2	1
R:R:D284	R:R:Y271	2.3	0	No	Yes	4	4	2	1
R:R:A86	R:R:Y35	1.33	0	No	Yes	6	7	2	1
L:L:R2	R:R:E20	1.16	0	No	No	0	5	0	1
L:L:Q1	R:R:Y271	1.13	0	No	Yes	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XQE_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.5
Number of Linked Nodes	544
Number of Links	620
Number of Hubs	88
Number of Links mediated by Hubs	333
Number of Communities	16
Number of Nodes involved in Communities	98
Number of Links involved in Communities	133

Path Summary
Number Of Nodes in MetaPath	86
Number Of Links MetaPath	85
Number of Shortest Paths	528731
Length Of Smallest Path	3
Average Path Length	27.1951
Length of Longest Path	54
Minimum Path Strength	1.23
Average Path Strength	7.17342
Maximum Path Strength	21.1
Minimum Path Correlation	0.7
Average Path Correlation	0.968859
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	45.9562
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.5392
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • apelin receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • positive regulation of biological process • positive regulation of heart rate • positive regulation of blood circulation • positive regulation of heart contraction • circulatory system process • regulation of blood circulation • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of biological quality • heart contraction • blood circulation • regulation of heart rate • regulation of heat generation • homeostatic process • positive regulation of heat generation • heat generation • multicellular organismal-level homeostasis • temperature homeostasis • response to fibroblast growth factor • cellular response to growth factor stimulus • negative regulation of signaling • negative regulation of biological process • regulation of signal transduction • negative regulation of cellular response to growth factor stimulus • cell surface receptor protein tyrosine kinase signaling pathway • negative regulation of cell communication • cellular response to endogenous stimulus • negative regulation of cellular process • enzyme-linked receptor protein signaling pathway • negative regulation of fibroblast growth factor receptor signaling pathway • regulation of signaling • cell surface receptor signaling pathway • negative regulation of response to stimulus • response to endogenous stimulus • regulation of cellular response to growth factor stimulus • negative regulation of signal transduction • regulation of response to stimulus • fibroblast growth factor receptor signaling pathway • regulation of cell communication • response to growth factor • cellular response to fibroblast growth factor stimulus • regulation of fibroblast growth factor receptor signaling pathway • regulation of tube diameter • regulation of tube size • negative regulation of vasoconstriction • vascular process in circulatory system • regulation of vasoconstriction • blood vessel diameter maintenance • negative regulation of multicellular organismal process • vasoconstriction • regulation of anatomical structure size • regulation of the force of heart contraction • developmental process • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • multicellular organism development • tube morphogenesis • anatomical structure formation involved in morphogenesis • anatomical structure development • blood vessel development • system development • immune response • immune system process • embryonic morphogenesis • embryo development • gastrulation • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of miRNA transcription • positive regulation of miRNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • DNA-templated transcription • nucleic acid biosynthetic process • positive regulation of metabolic process • regulation of RNA metabolic process • miRNA transcription • positive regulation of biosynthetic process • regulation of miRNA metabolic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • miRNA metabolic process • positive regulation of cellular process • regulation of RNA biosynthetic process • regulation of biosynthetic process • primary metabolic process • regulation of macromolecule metabolic process • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • regulation of metabolic process • regulation of miRNA transcription • behavior • drinking behavior • feeding behavior • regulation of localization • negative adaptation of signaling pathway • regulation of G protein-coupled receptor internalization • receptor internalization • regulation of receptor internalization • vesicle-mediated transport • negative regulation of G protein-coupled receptor signaling pathway • localization • positive regulation of endocytosis • regulation of G protein-coupled receptor signaling pathway • positive regulation of receptor-mediated endocytosis • positive regulation of G protein-coupled receptor internalization • establishment of localization • positive regulation of receptor internalization • adaptation of signaling pathway • receptor-mediated endocytosis • import into cell • regulation of cellular component organization • positive regulation of cellular component organization • transport • desensitization of G protein-coupled receptor signaling pathway • cellular component organization • cellular component organization or biogenesis • regulation of endocytosis • G protein-coupled receptor internalization • regulation of transport • regulation of receptor-mediated endocytosis • regulation of vesicle-mediated transport • positive regulation of transport • endocytosis • cell population proliferation • positive regulation of cell population proliferation • endothelial cell proliferation • positive regulation of epithelial cell proliferation • regulation of vascular endothelial cell proliferation • regulation of endothelial cell proliferation • regulation of cell population proliferation • positive regulation of endothelial cell proliferation • regulation of epithelial cell proliferation • vascular endothelial cell proliferation • epithelial cell proliferation • positive regulation of vascular endothelial cell proliferation • positive regulation of cell communication • nitrogen compound transport • regulation of peptide hormone secretion • positive regulation of corticotropin secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • regulation of secretion • endocrine hormone secretion • regulation of endocrine process • regulation of hormone secretion • regulation of peptide secretion • positive regulation of secretion by cell • hormone secretion • regulation of corticotropin secretion • peptide secretion • secretion by cell • regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • amide transport • signal release • positive regulation of peptide secretion • secretion • corticotropin secretion • regulation of peptide transport • cell-cell signaling • export from cell • peptide transport • endocrine process • peptide hormone secretion • hormone transport • positive regulation of signaling • regulation of body fluid levels • mammary gland development • gland development • animal organ development • body fluid secretion • lactation • regulation of systemic arterial blood pressure • regulation of blood pressure • negative regulation of systemic arterial blood pressure • negative regulation of blood pressure • positive regulation of phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • positive regulation of phosphate metabolic process • phosphate-containing compound metabolic process • regulation of phosphorus metabolic process • regulation of phosphorylation • phosphorus metabolic process • corticotropin-releasing hormone secretion • regulation of corticotropin-releasing hormone secretion • positive regulation of corticotropin-releasing hormone secretion • negative regulation of metabolic process • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of macromolecule metabolic process • heart development • coronary vasculature development • regulation of vascular associated smooth muscle cell proliferation • negative regulation of cell population proliferation • regulation of smooth muscle cell proliferation • negative regulation of vascular associated smooth muscle cell proliferation • smooth muscle cell proliferation • negative regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • cellular anatomical structure • extracellular region • intracellular anatomical structure • perinuclear region of cytoplasm • cytoplasm • extracellular space • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • apelin receptor activity • mechanoreceptor activity • atrioventricular valve development • heart valve development • cardiac chamber morphogenesis • heart morphogenesis • ventricular septum development • cardiac septum development • cardiac septum morphogenesis • ventricular septum morphogenesis • cardiac chamber development • animal organ morphogenesis • cardiac ventricle development • regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis • positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis • blood vessel endothelial cell proliferation involved in sprouting angiogenesis • sprouting angiogenesis • mesenchyme morphogenesis • endocardial cushion morphogenesis • mesenchyme development • tissue development • endocardial cushion formation • tissue morphogenesis • endocardial cushion development • artery development • aorta development • cellular developmental process • vasculogenesis • cell differentiation • regulation of developmental process • regulation of vasculature development • positive regulation of developmental process • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • positive regulation of angiogenesis • positive regulation of vasculature development • regulation of angiogenesis • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • venous blood vessel development • regulation of calcium ion transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • intracellular calcium ion homeostasis • calcium ion transport • positive regulation of monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation homeostasis • monoatomic cation transport • intracellular monoatomic ion homeostasis • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • chemical homeostasis • cellular localization • inorganic ion homeostasis • monoatomic ion transmembrane transport • calcium ion homeostasis • regulation of monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • metal ion transport • maintenance of location in cell • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • monoatomic ion transport • intracellular chemical homeostasis • positive regulation of release of sequestered calcium ion into cytosol • regulation of metal ion transport • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • sequestering of calcium ion • cellular homeostasis • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • negative regulation of muscle adaptation • striated muscle adaptation • negative regulation of muscle hypertrophy • regulation of muscle hypertrophy • regulation of cardiac muscle hypertrophy in response to stress • muscle adaptation • cardiac muscle adaptation • regulation of response to stress • response to stress • cardiac muscle hypertrophy • cardiac muscle hypertrophy in response to stress • muscle hypertrophy • regulation of muscle adaptation • negative regulation of cardiac muscle hypertrophy in response to stress • striated muscle hypertrophy • regulation of muscle system process • muscle system process • regulation of cardiac muscle hypertrophy • negative regulation of cardiac muscle adaptation • regulation of cardiac muscle adaptation • negative regulation of cardiac muscle hypertrophy • muscle hypertrophy in response to stress • adult heart development • positive regulation of cardiac muscle hypertrophy • positive regulation of cardiac muscle hypertrophy in response to stress • positive regulation of response to stimulus • positive regulation of muscle adaptation • positive regulation of cardiac muscle adaptation • positive regulation of muscle hypertrophy • smooth muscle cell differentiation • muscle cell differentiation • muscle structure development • vascular associated smooth muscle cell differentiation • gap junction assembly • regulation of gap junction assembly • regulation of cellular component biogenesis • cellular component biogenesis • regulation of cell junction assembly • cell junction organization • cellular component assembly • cell junction assembly • cell-cell junction assembly • cell-cell junction organization • pattern specification process • embryonic heart tube development • embryonic heart tube morphogenesis • heart looping • determination of bilateral symmetry • epithelial tube morphogenesis • embryonic organ development • determination of left/right symmetry • specification of symmetry • embryonic organ morphogenesis • epithelium development • morphogenesis of an epithelium • determination of heart left/right asymmetry • regionalization • left/right pattern formation • cell periphery • plasma membrane • membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • organelle • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of small molecule metabolic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • establishment of protein localization • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • negative regulation of peptide hormone secretion • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • negative regulation of protein secretion • regulation of protein localization • protein localization to extracellular region • negative regulation of peptide secretion • negative regulation of protein localization • regulation of establishment of protein localization • regulation of protein transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • macromolecule localization • insulin secretion • regulation of cytoskeleton organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cell cycle • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35414
Sequence	>8XQE_nogp_Chain_R C E Y T D W K S S G A L I P A I Y M L V F L L G T T G N G L V L W T V F R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D Y D W P F G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R P V A N A R L R L R V S G A V A T A V L W V L A A L L A M P V M V L R T T G D L E N T T K V Q C Y M D Y S M V A T V S S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R K E R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L L H W P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R F R Q A C T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	S
Protein	Receptor
UniProt	P35414
Sequence	>8XQE_nogp_Chain_S A L I P A I Y M L V F L L G T T G N G L V L W T V F R S S S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D Y D W P F G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R P V A N A R L R L R V S G A V A T A V L W V L A A L L A M P V M V L R T T G D L E N T T K V Q C Y M D Y S M V A T V S S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R K E R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L L H W P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XZF	A	Peptide	Apelin	Apelin	Homo sapiens	WN561	-	Gi1/β1/γ2	3	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZF (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	WN561	-		3	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZG	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-	Gi1/β1/γ2	3.2	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZG (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-		3.2	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZH	A	Peptide	Apelin	Apelin	Homo sapiens	MM07	-	Gi1/β1/γ2	2.06	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZH (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	MM07	-		2.06	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZJ	A	Peptide	Apelin	Apelin	Homo sapiens	WN353	-	Gi1/β1/γ2	3	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZJ (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	WN353	-		3	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	5VBL	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin mimetic peptide agonist	-	-	2.6	2017-05-31	doi.org/10.1016/j.str.2017.04.008
	8Z74	A	Peptide	Apelin	Apelin	Homo sapiens	Agonistic antibody	-	-	3.01	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8Z7J	A	Peptide	Apelin	Apelin	Homo sapiens	Agonistic antibody	-	Gi1/β1/γ2	3.12	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8Z7J (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Agonistic antibody	-		3.12	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	7SUS	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-	-	2.7	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0L	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-	Gi1/β1/γ2	3.57	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0L (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-		3.57	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0M	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-	Gi1/β1/γ2	3.71	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0M (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-		3.71	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0N	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-	Gi1/β1/γ2	4.21	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0N (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-		4.21	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0O	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-	Gi1/β1/γ2	3.78	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0O (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-		3.78	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0P	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-	Gi1/β1/γ2	3.16	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0P (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-		3.16	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	6KNM	A	Peptide	Apelin	Apelin	Homo sapiens	JN241-9	-	-	3.2	2020-01-29	doi.org/10.1126/sciadv.aax7379
	8XZI	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-	Gi1/β1/γ2	2.7	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZI (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-		2.7	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8S4D	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-	-	2.58	2024-12-04	doi.org/10.1038/s41467-024-55381-w
	8XQE	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-	Gi1/β1/γ2	3.48	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQE (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-		3.48	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQF	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-	Gi1/β1/γ2	3.13	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQF (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-		3.13	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQI	A	Peptide	Apelin	Apelin	Homo sapiens	-	-	-	3.25	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQJ	A	Peptide	Apelin	Apelin	Homo sapiens	JN241	-	-	2.95	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	9JH3	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-	Gi1/β1/γ2	2.93	2025-04-23	doi.org/10.1073/pnas.2423432122
	9JH3 (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-		2.93	2025-04-23	doi.org/10.1073/pnas.2423432122

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