psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C1	L:L:C6	5.46	No	No	0	0	0
2	L:L:C1	R:R:Y182	5.38	No	No	0	0	4
3	L:L:P3	L:L:R2	5.76	No	Yes	3	0	0
4	L:L:R2	R:R:E194	8.14	Yes	Yes	0	0	6
5	L:L:R2	R:R:W195	5	Yes	No	0	0	2
6	L:L:R2	R:R:E198	9.3	Yes	No	3	0	4
7	L:L:C6	L:L:P3	7.53	No	No	0	0	0
8	L:L:P3	R:R:E198	17.29	No	No	3	0	4
9	L:L:R4	R:R:Y21	5.14	No	No	0	0	4
10	L:L:R4	R:R:Y271	4.12	No	Yes	0	0	4
11	L:L:L5	R:R:Y271	8.21	No	Yes	0	0	4
12	L:L:L5	R:R:F291	9.74	No	Yes	0	0	4
13	L:L:C6	L:L:H7	4.42	No	No	0	0	0
14	L:L:H7	L:L:K8	6.55	No	No	0	0	0
15	L:L:K8	R:R:Y93	9.55	No	No	0	0	4
16	L:L:G9	L:L:P10	4.06	No	Yes	0	0	0
17	L:L:P10	R:R:W85	16.21	Yes	Yes	0	0	6
18	L:L:P10	R:R:I109	10.16	Yes	No	0	0	6
19	L:L:P10	R:R:Y299	5.56	Yes	Yes	0	0	7
20	L:L:M11	R:R:Y264	9.58	No	Yes	0	0	6
21	L:L:F13	L:L:P12	8.67	No	Yes	1	0	0
22	L:L:P12	R:R:F110	7.22	Yes	Yes	1	0	5
23	L:L:P12	R:R:V164	7.07	Yes	No	0	0	4
24	L:L:P12	R:R:R168	5.76	Yes	Yes	1	0	5
25	L:L:P12	R:R:M183	8.39	Yes	Yes	1	0	5
26	L:L:F13	R:R:F110	8.57	No	Yes	1	0	5
27	L:L:F13	R:R:L201	10.96	No	No	0	0	4
28	R:R:C19	R:R:C281	7.28	No	No	0	8	8
29	R:R:E20	R:R:T22	9.88	No	No	0	5	4
30	R:R:D284	R:R:Y21	5.75	No	No	0	4	4
31	R:R:N289	R:R:W24	23.73	No	No	0	2	1
32	R:R:S27	R:R:Y293	6.36	No	No	0	3	5
33	R:R:I31	R:R:Y35	7.25	No	Yes	0	6	7
34	R:R:I31	R:R:Y293	9.67	No	No	0	6	5
35	R:R:P32	R:R:T89	6.99	No	No	0	5	5
36	R:R:P32	R:R:Y90	4.17	No	No	0	5	3
37	R:R:C296	R:R:I34	4.91	No	No	0	5	5
38	R:R:C296	R:R:Y35	5.38	No	Yes	0	5	7
39	R:R:Y299	R:R:Y35	5.96	Yes	Yes	0	7	7
40	R:R:M36	R:R:P83	8.39	No	No	0	3	9
41	R:R:F39	R:R:T43	5.19	No	No	0	6	5
42	R:R:F39	R:R:P83	15.89	No	No	0	6	9
43	R:R:L76	R:R:T43	4.42	No	No	0	7	5
44	R:R:D75	R:R:N46	5.39	Yes	No	0	9	9
45	R:R:N46	R:R:P306	8.15	No	No	0	9	9
46	R:R:F311	R:R:V49	3.93	Yes	Yes	0	6	8
47	R:R:F54	R:R:L50	4.87	Yes	No	0	3	7
48	R:R:R55	R:R:W51	5	No	No	0	6	3
49	R:R:M323	R:R:W51	10.47	No	No	0	5	3
50	R:R:L324	R:R:W51	5.69	No	No	0	6	3
51	R:R:F316	R:R:T52	9.08	Yes	No	0	9	7
52	R:R:C320	R:R:T52	6.76	No	No	0	6	7
53	R:R:F54	R:R:R55	4.28	Yes	No	0	3	6
54	R:R:D65	R:R:R62	7.15	No	No	0	8	7
55	R:R:D313	R:R:R62	14.29	No	No	0	8	7
56	R:R:F316	R:R:R62	4.28	Yes	No	0	9	7
57	R:R:R141	R:R:S63	3.95	Yes	No	0	7	6
58	R:R:I66	R:R:T150	4.56	No	No	0	5	6
59	R:R:F67	R:R:L123	8.53	Yes	No	0	7	8
60	R:R:D126	R:R:F67	4.78	No	Yes	0	8	7
61	R:R:S70	R:R:W154	4.94	No	Yes	0	9	9
62	R:R:D75	R:R:L71	5.43	Yes	Yes	4	9	9
63	R:R:C119	R:R:L71	4.76	No	Yes	0	7	9
64	R:R:L120	R:R:L71	5.54	No	Yes	0	8	9
65	R:R:L71	R:R:N305	4.12	Yes	No	4	9	9
66	R:R:D75	R:R:S116	4.42	Yes	No	0	9	9
67	R:R:D75	R:R:S302	10.31	Yes	No	0	9	8
68	R:R:D75	R:R:N305	6.73	Yes	No	4	9	9
69	R:R:L108	R:R:T77	4.42	No	No	0	4	7
70	R:R:N112	R:R:T77	8.77	No	No	0	8	7
71	R:R:F78	R:R:W261	4.01	No	Yes	0	6	9
72	R:R:F78	R:R:Y299	8.25	No	Yes	0	6	7
73	R:R:F78	R:R:S302	6.61	No	No	0	6	8
74	R:R:S105	R:R:T81	6.4	No	No	0	5	7
75	R:R:L82	R:R:Y299	7.03	No	Yes	0	7	7
76	R:R:F97	R:R:L84	6.09	Yes	No	0	6	6
77	R:R:L84	R:R:S105	4.5	No	No	0	6	5
78	R:R:W85	R:R:Y88	6.75	Yes	Yes	1	6	5
79	R:R:W85	R:R:W95	12.18	Yes	Yes	1	6	8
80	R:R:S105	R:R:W85	4.94	No	Yes	0	5	6
81	R:R:R168	R:R:W85	5	Yes	Yes	1	5	6
82	R:R:C181	R:R:W85	6.53	Yes	Yes	1	9	6
83	R:R:F97	R:R:T87	5.19	Yes	No	0	6	4
84	R:R:Y88	R:R:Y93	9.93	Yes	No	0	5	4
85	R:R:W95	R:R:Y88	10.61	Yes	Yes	1	8	5
86	R:R:T89	R:R:Y93	4.99	No	No	0	5	4
87	R:R:D94	R:R:R91	13.1	No	No	0	4	3
88	R:R:P96	R:R:R91	14.41	No	No	0	4	3
89	R:R:D94	R:R:K178	11.06	No	No	0	4	2
90	R:R:F97	R:R:W95	20.04	Yes	Yes	0	6	8
91	R:R:C102	R:R:W95	9.14	No	Yes	1	9	8
92	R:R:C181	R:R:W95	13.06	Yes	Yes	1	9	8
93	R:R:F97	R:R:P96	8.67	Yes	No	0	6	4
94	R:R:K103	R:R:T99	4.5	No	No	0	7	3
95	R:R:T170	R:R:T99	9.42	No	No	0	5	3
96	R:R:F100	R:R:F101	6.43	No	No	0	1	5
97	R:R:C102	R:R:T170	5.07	No	No	0	9	5
98	R:R:C102	R:R:C181	7.28	No	Yes	1	9	9
99	R:R:R168	R:R:S106	9.22	Yes	No	0	5	5
100	R:R:V111	R:R:Y107	8.83	No	Yes	0	4	5
101	R:R:M162	R:R:Y107	8.38	No	Yes	0	4	5
102	R:R:V164	R:R:Y107	3.79	No	Yes	0	4	5
103	R:R:M165	R:R:Y107	9.58	No	Yes	0	5	5
104	R:R:F110	R:R:Y114	9.28	Yes	Yes	1	5	6
105	R:R:A161	R:R:F110	4.16	No	Yes	0	7	5
106	R:R:F110	R:R:S205	3.96	Yes	No	1	5	4
107	R:R:N112	R:R:V111	4.43	No	No	0	8	4
108	R:R:M113	R:R:W261	6.98	No	Yes	0	7	9
109	R:R:F118	R:R:Y114	5.16	No	Yes	0	5	6
110	R:R:L160	R:R:Y114	4.69	No	Yes	0	4	6
111	R:R:S205	R:R:Y114	3.82	No	Yes	1	4	6
112	R:R:A115	R:R:W154	7.78	No	Yes	0	7	9
113	R:R:F257	R:R:V117	7.87	Yes	No	0	8	7
114	R:R:F118	R:R:L153	7.31	No	No	0	5	6
115	R:R:F118	R:R:L156	6.09	No	No	0	5	4
116	R:R:C119	R:R:L153	4.76	No	No	0	7	6
117	R:R:L120	R:R:Y309	5.86	No	Yes	0	8	9
118	R:R:P213	R:R:T121	5.25	No	No	0	9	7
119	R:R:I216	R:R:T121	6.08	No	No	0	6	7
120	R:R:M217	R:R:T121	4.52	No	No	0	8	7
121	R:R:L123	R:R:Y309	4.69	No	Yes	0	8	9
122	R:R:M217	R:R:S124	9.2	No	No	0	8	9
123	R:R:S124	R:R:Y221	10.17	No	Yes	0	9	8
124	R:R:F125	R:R:L129	10.96	No	Yes	0	6	5
125	R:R:D126	R:R:R141	11.91	No	Yes	0	8	7
126	R:R:D126	R:R:S145	5.89	No	No	0	8	4
127	R:R:R127	R:R:Y221	8.23	No	Yes	0	9	8
128	R:R:R127	R:R:Y309	6.17	No	Yes	0	9	9
129	R:R:V132	R:R:Y128	15.14	No	No	0	7	8
130	R:R:C220	R:R:Y128	5.38	No	No	0	6	8
131	R:R:F223	R:R:Y128	4.13	No	No	0	5	8
132	R:R:L129	R:R:N137	5.49	Yes	No	0	5	6
133	R:R:L129	R:R:R141	4.86	Yes	Yes	0	5	7
134	R:R:A130	R:R:R141	5.53	No	Yes	0	8	7
135	R:R:I131	R:R:I224	4.42	No	No	0	8	8
136	R:R:T227	R:R:V132	4.76	No	No	0	4	7
137	R:R:N137	R:R:R133	8.44	No	No	0	6	6
138	R:R:L140	R:R:V144	5.96	No	No	0	4	4
139	R:R:L153	R:R:W154	6.83	No	Yes	0	6	9
140	R:R:L167	R:R:M183	5.65	No	Yes	0	5	5
141	R:R:D184	R:R:L167	5.43	No	No	0	3	5
142	R:R:C181	R:R:R168	6.96	Yes	Yes	1	9	5
143	R:R:M183	R:R:R168	7.44	Yes	Yes	1	5	5
144	R:R:T169	R:R:Y182	8.74	No	No	0	4	4
145	R:R:D184	R:R:T169	4.34	No	No	0	3	4
146	R:R:G171	R:R:Y182	5.79	No	No	0	1	4
147	R:R:L173	R:R:N175	12.36	No	No	0	3	2
148	R:R:K178	R:R:T176	7.51	No	No	0	2	3
149	R:R:M183	R:R:Y185	10.78	Yes	No	0	5	5
150	R:R:D184	R:R:M187	12.48	No	No	0	3	2
151	R:R:E194	R:R:Y185	5.61	Yes	No	0	6	5
152	R:R:V188	R:R:W197	15.94	No	No	0	2	2
153	R:R:A189	R:R:W197	5.19	No	No	0	1	2
154	R:R:S193	R:R:T190	4.8	No	No	0	4	1
155	R:R:E194	R:R:V191	4.28	Yes	No	0	6	2
156	R:R:H265	R:R:T206	10.95	Yes	No	2	8	5
157	R:R:K268	R:R:T206	6.01	No	No	2	5	5
158	R:R:F210	R:R:F214	7.5	Yes	Yes	2	8	6
159	R:R:F210	R:R:F257	5.36	Yes	Yes	2	8	8
160	R:R:F210	R:R:M262	7.46	Yes	No	0	8	5
161	R:R:F210	R:R:H265	10.18	Yes	Yes	2	8	8
162	R:R:F214	R:R:L218	4.87	Yes	No	0	6	4
163	R:R:F214	R:R:F257	7.5	Yes	Yes	2	6	8
164	R:R:A258	R:R:F214	4.16	No	Yes	0	5	6
165	R:R:F257	R:R:M217	4.98	Yes	No	0	8	8
166	R:R:I250	R:R:Y221	6.04	No	Yes	0	7	8
167	R:R:L253	R:R:Y221	4.69	No	Yes	0	7	8
168	R:R:V254	R:R:Y221	3.79	No	Yes	0	7	8
169	R:R:F222	R:R:F223	5.36	No	No	0	3	5
170	R:R:F222	R:R:Q226	12.88	No	No	0	3	3
171	R:R:I228	R:R:L246	9.99	No	No	0	8	7
172	R:R:I228	R:R:L247	4.28	No	No	0	8	6
173	R:R:A229	R:R:R243	4.15	No	No	0	4	6
174	R:R:F232	R:R:K242	6.2	Yes	No	0	4	5
175	R:R:F232	R:R:L246	4.87	Yes	No	0	4	7
176	R:R:K234	R:R:R243	7.43	No	No	0	3	6
177	R:R:E238	R:R:I237	9.56	No	No	0	4	3
178	R:R:L240	R:R:R244	12.15	No	No	0	4	5
179	R:R:F312	R:R:R245	5.34	No	No	0	6	7
180	R:R:I249	R:R:L253	4.28	No	No	0	7	7
181	R:R:F312	R:R:I249	17.58	No	No	0	6	7
182	R:R:L253	R:R:Y309	10.55	No	Yes	0	7	9
183	R:R:L308	R:R:T256	4.42	No	No	0	8	6
184	R:R:F257	R:R:W261	9.02	Yes	Yes	0	8	9
185	R:R:C260	R:R:N301	11.02	No	Yes	0	7	9
186	R:R:W261	R:R:Y264	3.86	Yes	Yes	0	9	6
187	R:R:S298	R:R:W261	9.88	No	Yes	0	7	9
188	R:R:N301	R:R:W261	7.91	Yes	Yes	0	9	9
189	R:R:H265	R:R:Y264	8.71	Yes	Yes	2	8	6
190	R:R:K268	R:R:Y264	5.97	No	Yes	2	5	6
191	R:R:F291	R:R:Y264	5.16	Yes	Yes	0	4	6
192	R:R:H265	R:R:K268	3.93	Yes	No	2	8	5
193	R:R:L266	R:R:L270	6.92	No	No	0	6	5
194	R:R:F291	R:R:V267	5.24	Yes	No	0	4	4
195	R:R:L270	R:R:L287	4.15	No	No	0	5	4
196	R:R:D284	R:R:Y271	4.6	No	Yes	0	4	4
197	R:R:M288	R:R:Y271	5.99	No	Yes	0	4	4
198	R:R:L273	R:R:L277	4.15	No	No	0	4	1
199	R:R:G274	R:R:W279	5.63	No	No	0	3	1
200	R:R:F283	R:R:W279	17.04	No	No	0	3	1
201	R:R:D284	R:R:W279	12.28	No	No	0	4	1
202	R:R:F283	R:R:L287	13.4	No	No	0	3	4
203	R:R:F286	R:R:I290	8.79	No	No	0	1	4
204	R:R:M288	R:R:N289	5.61	No	No	0	4	2
205	R:R:F291	R:R:T295	5.19	Yes	No	0	4	5
206	R:R:T295	R:R:Y299	6.24	No	Yes	0	5	7
207	R:R:N301	R:R:N305	5.45	Yes	No	0	9	9
208	R:R:F307	R:R:F311	4.29	No	Yes	0	6	6
209	R:R:F311	R:R:F316	5.36	Yes	Yes	0	6	9
210	R:R:F311	R:R:R317	4.28	Yes	No	0	6	8
211	R:R:C320	R:R:F311	4.19	No	Yes	0	6	6
212	R:R:D313	R:R:P314	6.44	No	No	0	8	5
213	R:R:D313	R:R:R315	15.48	No	No	0	8	7
214	R:R:P314	R:R:R317	5.76	No	No	0	5	8
215	R:R:F67	R:R:I66	3.77	Yes	No	0	7	5
216	R:R:C294	R:R:P263	3.77	No	No	0	6	9
217	R:R:V199	R:R:W195	3.68	No	No	0	3	2
218	R:R:F39	R:R:L40	3.65	No	No	0	6	5
219	R:R:G45	R:R:T44	3.64	No	No	0	8	4
220	R:R:L140	R:R:R143	3.64	No	No	0	4	3
221	R:R:P306	R:R:V49	3.53	No	Yes	0	9	8
222	R:R:P213	R:R:V212	3.53	No	No	0	9	6
223	R:R:L285	R:R:Y21	3.52	No	No	0	3	4
224	R:R:C220	R:R:S124	3.44	No	No	0	6	9
225	R:R:C303	R:R:V38	3.42	No	No	0	7	7
226	R:R:A189	R:R:S193	3.42	No	No	0	1	4
227	R:R:L201	R:R:W197	3.42	No	No	0	4	2
228	R:R:C294	R:R:V267	3.42	No	No	0	6	4
229	R:R:I31	R:R:P292	3.39	No	No	0	6	4
230	R:R:A72	R:R:V49	3.39	No	Yes	0	8	8
231	R:R:A310	R:R:V49	3.39	No	Yes	0	6	8
232	R:R:Q180	R:R:Y88	3.38	No	Yes	0	2	5
233	R:R:L201	R:R:P163	3.28	No	No	0	4	8
234	R:R:C294	R:R:I290	3.27	No	No	0	6	4
235	R:R:A64	R:R:I68	3.25	No	No	0	8	8
236	R:R:A310	R:R:I68	3.25	No	No	0	6	8
237	R:R:S302	R:R:V79	3.23	No	No	0	8	6
238	R:R:A86	R:R:M36	3.22	No	No	0	6	3
239	R:R:F232	R:R:R243	3.21	Yes	No	0	4	6
240	R:R:C303	R:R:L41	3.17	No	No	0	7	5
241	R:R:T170	R:R:V179	3.17	No	No	0	5	5
242	R:R:A72	R:R:L50	3.15	No	No	0	8	7
243	R:R:T206	R:R:T269	3.14	No	No	0	5	6
244	R:R:I249	R:R:V252	3.07	No	No	0	7	5
245	R:R:I131	R:R:T227	3.04	No	No	0	8	4
246	R:R:M272	R:R:V199	3.04	No	No	0	5	3
247	R:R:F67	R:R:G122	3.01	Yes	No	0	7	6
248	R:R:L30	R:R:S26	3	No	No	0	5	3
249	R:R:L276	R:R:S275	3	No	No	0	1	4
250	R:R:L50	R:R:V73	2.98	No	No	0	7	5
251	R:R:L167	R:R:V166	2.98	No	No	0	5	4
252	R:R:L259	R:R:V255	2.98	No	No	0	5	4
253	R:R:L304	R:R:V300	2.98	No	No	0	6	5
254	R:R:L173	R:R:T176	2.95	No	No	0	3	3
255	R:R:I224	R:R:I228	2.94	No	No	0	8	8
256	R:R:N301	R:R:T256	2.92	Yes	No	0	9	6
257	R:R:D172	R:R:T177	2.89	No	No	0	1	5
258	R:R:F283	R:R:P280	2.89	No	No	0	3	4
259	R:R:E194	R:R:S186	2.87	Yes	No	0	6	5
260	R:R:D23	R:R:M288	2.77	No	No	0	5	4
261	R:R:L324	R:R:L48	2.77	No	No	0	6	5
262	R:R:A69	R:R:F54	2.77	No	Yes	0	5	3
263	R:R:A149	R:R:F67	2.77	No	Yes	0	5	7
264	R:R:L104	R:R:L108	2.77	No	No	0	5	4
265	R:R:L129	R:R:L140	2.77	Yes	No	0	5	4
266	R:R:A86	R:R:Y35	2.67	No	Yes	0	6	7
267	L:L:R2	R:R:S275	2.64	Yes	No	0	0	4
268	R:R:F54	R:R:V53	2.62	Yes	No	0	3	6
269	R:R:F316	R:R:V53	2.62	Yes	No	0	9	6
270	R:R:A74	R:R:W154	2.59	No	Yes	0	8	9
271	R:R:A196	R:R:W195	2.59	No	No	0	1	2
272	R:R:F223	R:R:T219	2.59	No	No	0	5	4
273	R:R:V38	R:R:Y299	2.52	No	Yes	0	7	7
274	R:R:F100	R:R:L104	2.44	No	No	0	1	5
275	R:R:Q318	R:R:R317	2.34	No	No	0	6	8
276	R:R:R233	R:R:R236	2.13	No	No	0	4	2
277	R:R:G28	R:R:P32	2.03	No	No	0	3	5
278	R:R:G45	R:R:P306	2.03	No	No	0	8	9
279	R:R:G209	R:R:P213	2.03	No	No	0	5	9
280	R:R:C303	R:R:G42	1.96	No	No	0	7	8
281	R:R:G146	R:R:S145	1.86	No	No	0	7	4
282	R:R:G202	R:R:S205	1.86	No	No	0	5	4
283	R:R:G200	R:R:V199	1.84	No	No	0	2	3
284	R:R:A115	R:R:A157	1.79	No	No	0	7	7
285	R:R:G274	R:R:L277	1.71	No	No	0	3	1
286	R:R:C325	R:R:T321	1.69	No	No	0	1	4
287	R:R:A319	R:R:T52	1.68	No	No	0	5	7
288	R:R:A147	R:R:T150	1.68	No	No	0	4	6
289	R:R:A225	R:R:I250	1.62	No	No	0	5	7
290	R:R:V300	R:R:V38	1.6	No	No	0	5	7
291	R:R:S192	R:R:T190	1.6	No	No	0	2	1
292	R:R:V251	R:R:V255	1.6	No	No	0	3	4
293	R:R:T77	R:R:V80	1.59	No	No	0	7	4
294	R:R:T81	R:R:V80	1.59	No	No	0	7	4
295	R:R:T207	R:R:V203	1.59	No	No	0	3	4
296	R:R:T207	R:R:V211	1.59	No	No	0	3	4
297	R:R:T207	R:R:V212	1.59	No	No	0	3	6
298	R:R:T215	R:R:V211	1.59	No	No	0	2	4
299	R:R:A136	R:R:N137	1.56	No	No	0	4	6
300	R:R:F232	R:R:G239	1.51	Yes	No	0	4	4
301	R:R:G239	R:R:R236	1.5	No	No	0	4	2
302	R:R:L160	R:R:V208	1.49	No	No	0	4	5
303	R:R:L285	R:R:T22	1.47	No	No	0	3	4
304	R:R:P134	R:R:R133	1.44	No	No	0	8	6
305	R:R:I34	R:R:L30	1.43	No	No	0	5	5
306	R:R:G98	R:R:W95	1.41	No	Yes	0	8	8
307	R:R:E174	R:R:T177	1.41	No	No	0	2	5
308	R:R:K234	R:R:L240	1.41	No	No	0	3	4
309	R:R:L37	R:R:L41	1.38	No	No	0	5	5
310	R:R:D92	R:R:K178	1.38	No	No	0	6	2
311	R:R:H231	R:R:T227	1.37	No	No	0	5	4
312	R:R:A158	R:R:Y107	1.33	No	Yes	0	4	5
313	R:R:E235	R:R:R233	1.16	No	No	0	4	4
314	R:R:E238	R:R:R236	1.16	No	No	0	4	2
315	R:R:R139	R:R:R143	1.07	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:R2	6.168	5	3	0
2	L:L:P10	8.9975	4	0	0
3	L:L:P12	7.422	5	1	0
4	R:R:Y35	5.315	4	0	7
5	R:R:V49	3.56	4	0	8
6	R:R:F54	3.635	4	0	3
7	R:R:F67	4.572	5	0	7
8	R:R:L71	4.9625	4	4	9
9	R:R:D75	6.456	5	4	9
10	R:R:W85	8.60167	6	1	6
11	R:R:Y88	7.6675	4	1	5
12	R:R:W95	11.0733	6	1	8
13	R:R:F97	9.9975	4	0	6
14	R:R:Y107	6.382	5	0	5
15	R:R:F110	6.638	5	1	5
16	R:R:Y114	5.7375	4	1	6
17	R:R:L129	6.02	4	0	5
18	R:R:R141	6.5625	4	0	7
19	R:R:W154	5.535	4	0	9
20	R:R:R168	6.876	5	1	5
21	R:R:C181	8.4575	4	1	9
22	R:R:M183	8.065	4	1	5
23	R:R:E194	5.225	4	0	6
24	R:R:F210	7.625	4	2	8
25	R:R:F214	6.0075	4	2	6
26	R:R:Y221	6.584	5	0	8
27	R:R:F232	3.9475	4	0	4
28	R:R:F257	6.946	5	2	8
29	R:R:W261	6.94333	6	0	9
30	R:R:Y264	6.656	5	2	6
31	R:R:H265	8.4425	4	2	8
32	R:R:Y271	5.73	4	0	4
33	R:R:F291	6.3325	4	0	4
34	R:R:Y299	5.92667	6	0	7
35	R:R:N301	6.825	4	0	9
36	R:R:Y309	6.8175	4	0	9
37	R:R:F311	4.41	5	0	6
38	R:R:F316	5.335	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:R2	R:R:E194	17.3388	8.14	Yes	Yes	0	0	6
2	R:R:Y88	R:R:Y93	15.9255	9.93	Yes	No	0	5	4
3	R:R:W85	R:R:Y88	17.5859	6.75	Yes	Yes	1	6	5
4	L:L:P10	R:R:W85	98.0294	16.21	Yes	Yes	0	0	6
5	L:L:P10	R:R:Y299	100	5.56	Yes	Yes	0	0	7
6	R:R:T295	R:R:Y299	35.5682	6.24	No	Yes	0	5	7
7	R:R:F291	R:R:T295	34.6375	5.19	Yes	No	0	4	5
8	L:L:L5	R:R:F291	50.6377	9.74	No	Yes	0	0	4
9	L:L:L5	R:R:Y271	48.828	8.21	No	Yes	0	0	4
10	L:L:R4	R:R:Y271	10.324	4.12	No	Yes	0	0	4
11	R:R:D284	R:R:Y271	29.2485	4.6	No	Yes	0	4	4
12	R:R:F78	R:R:Y299	94.2721	8.25	No	Yes	0	6	7
13	R:R:F78	R:R:W261	66.5403	4.01	No	Yes	0	6	9
14	R:R:W261	R:R:Y264	43.2954	3.86	Yes	Yes	0	9	6
15	R:R:F291	R:R:Y264	38.9521	5.16	Yes	Yes	0	4	6
16	R:R:L167	R:R:M183	12.5417	5.65	No	Yes	0	5	5
17	L:L:F13	L:L:P12	11.0594	8.67	No	Yes	1	0	0
18	L:L:P12	R:R:F110	19.6599	7.22	Yes	Yes	1	0	5
19	L:L:P12	R:R:V164	13.8171	7.07	Yes	No	0	0	4
20	R:R:M183	R:R:R168	27.7433	7.44	Yes	Yes	1	5	5
21	L:L:F13	R:R:L201	14.3744	10.96	No	No	0	0	4
22	R:R:L285	R:R:Y21	12.714	3.52	No	No	0	3	4
23	R:R:Y299	R:R:Y35	27.6629	5.96	Yes	Yes	0	7	7
24	R:R:A86	R:R:Y35	12.4612	2.67	No	Yes	0	6	7
25	R:R:A86	R:R:M36	10.7147	3.22	No	No	0	6	3
26	R:R:F78	R:R:S302	67.7238	6.61	No	No	0	6	8
27	R:R:D75	R:R:S302	66.0577	10.31	Yes	No	0	9	8
28	R:R:D75	R:R:N46	91.9855	5.39	Yes	No	0	9	9
29	R:R:N46	R:R:P306	89.607	8.15	No	No	0	9	9
30	R:R:P306	R:R:V49	82.4026	3.53	No	Yes	0	9	8
31	R:R:F311	R:R:V49	46.9608	3.93	Yes	Yes	0	6	8
32	R:R:A72	R:R:V49	25.9795	3.39	No	Yes	0	8	8
33	R:R:A72	R:R:L50	23.3138	3.15	No	No	0	8	7
34	R:R:F54	R:R:L50	18.1547	4.87	Yes	No	0	3	7
35	R:R:F54	R:R:R55	13.2541	4.28	Yes	No	0	3	6
36	R:R:R55	R:R:W51	10.5309	5	No	No	0	6	3
37	R:R:F311	R:R:F316	21.2628	5.36	Yes	Yes	0	6	9
38	R:R:F316	R:R:R62	10.7377	4.28	Yes	No	0	9	7
39	R:R:F311	R:R:R317	13.5183	4.28	Yes	No	0	6	8
40	R:R:D75	R:R:L71	43.9044	5.43	Yes	Yes	4	9	9
41	R:R:L120	R:R:L71	58.8245	5.54	No	Yes	0	8	9
42	R:R:L120	R:R:Y309	58.1351	5.86	No	Yes	0	8	9
43	R:R:L123	R:R:Y309	43.9848	4.69	No	Yes	0	8	9
44	R:R:F67	R:R:L123	42.2153	8.53	Yes	No	0	7	8
45	R:R:D126	R:R:F67	31.3283	4.78	No	Yes	0	8	7
46	R:R:D126	R:R:R141	25.6808	11.91	No	Yes	0	8	7
47	R:R:F110	R:R:Y114	21.7913	9.28	Yes	Yes	1	5	6
48	R:R:F118	R:R:Y114	24.2503	5.16	No	Yes	0	5	6
49	R:R:F118	R:R:L153	25.4682	7.31	No	No	0	5	6
50	R:R:C119	R:R:L153	29.846	4.76	No	No	0	7	6
51	R:R:C119	R:R:L71	30.7021	4.76	No	Yes	0	7	9
52	R:R:N301	R:R:W261	34.9477	7.91	Yes	Yes	0	9	9
53	R:R:N301	R:R:N305	32.3739	5.45	Yes	No	0	9	9
54	R:R:D75	R:R:N305	20.5274	6.73	Yes	No	4	9	9
55	R:R:S105	R:R:W85	15.351	4.94	No	Yes	0	5	6
56	R:R:S105	R:R:T81	12.6508	6.4	No	No	0	5	7
57	R:R:T81	R:R:V80	10.979	1.59	No	No	0	7	4
58	R:R:V164	R:R:Y107	11.8925	3.79	No	Yes	0	4	5
59	R:R:F97	R:R:W95	20.1023	20.04	Yes	Yes	0	6	8
60	R:R:F97	R:R:P96	16.5862	8.67	Yes	No	0	6	4
61	R:R:P96	R:R:R91	14.5525	14.41	No	No	0	4	3
62	R:R:D94	R:R:R91	12.5072	13.1	No	No	0	4	3
63	R:R:D94	R:R:K178	10.4504	11.06	No	No	0	4	2
64	R:R:C102	R:R:T170	12.174	5.07	No	No	0	9	5
65	R:R:F257	R:R:W261	70.1195	9.02	Yes	Yes	0	8	9
66	R:R:F257	R:R:M217	66.006	4.98	Yes	No	0	8	8
67	R:R:M217	R:R:T121	18.4017	4.52	No	No	0	8	7
68	R:R:P213	R:R:T121	14.3916	5.25	No	No	0	9	7
69	R:R:M217	R:R:S124	55.7222	9.2	No	No	0	8	9
70	R:R:S124	R:R:Y221	41.3076	10.17	No	Yes	0	9	8
71	R:R:L129	R:R:R141	19.9299	4.86	Yes	Yes	0	5	7
72	R:R:R127	R:R:Y221	18.7464	8.23	No	Yes	0	9	8
73	R:R:R127	R:R:Y309	18.8958	6.17	No	Yes	0	9	9
74	R:R:C220	R:R:S124	66.3277	3.44	No	No	0	6	9
75	R:R:C220	R:R:Y128	64.0009	5.38	No	No	0	6	8
76	R:R:V132	R:R:Y128	52.1946	15.14	No	No	0	7	8
77	R:R:F223	R:R:Y128	10.4274	4.13	No	No	0	5	8
78	R:R:T227	R:R:V132	49.7932	4.76	No	No	0	4	7
79	R:R:I131	R:R:T227	45.1454	3.04	No	No	0	8	4
80	R:R:I131	R:R:I224	42.7209	4.42	No	No	0	8	8
81	R:R:E194	R:R:Y185	22.182	5.61	Yes	No	0	6	5
82	R:R:L201	R:R:W197	10.8871	3.42	No	No	0	4	2
83	R:R:L253	R:R:Y221	22.5325	4.69	No	Yes	0	7	8
84	R:R:L253	R:R:Y309	23.6815	10.55	No	Yes	0	7	9
85	R:R:I224	R:R:I228	40.2792	2.94	No	No	0	8	8
86	R:R:I228	R:R:L246	35.5222	9.99	No	No	0	8	7
87	R:R:F232	R:R:L246	33.2184	4.87	Yes	No	0	4	7
88	R:R:F232	R:R:R243	13.007	3.21	Yes	No	0	4	6
89	R:R:F232	R:R:G239	15.5751	1.51	Yes	No	0	4	4
90	R:R:G239	R:R:R236	13.007	1.5	No	No	0	4	2
91	R:R:D284	R:R:W279	19.1256	12.28	No	No	0	4	1
92	R:R:F283	R:R:W279	10.7377	17.04	No	No	0	3	1
93	R:R:F291	R:R:V267	10.8239	5.24	Yes	No	0	4	4
94	R:R:P213	R:R:V212	10.3355	3.53	No	No	0	9	6
95	R:R:V38	R:R:Y299	12.4612	2.52	No	Yes	0	7	7
96	R:R:M183	R:R:Y185	23.8309	10.78	Yes	No	0	5	5
97	R:R:R168	R:R:W85	50.3792	5	Yes	Yes	1	5	6
98	R:R:L71	R:R:N305	12.0878	4.12	Yes	No	4	9	9
99	R:R:W85	R:R:W95	25.1178	12.18	Yes	Yes	1	6	8
100	L:L:P12	R:R:R168	26.4621	5.76	Yes	Yes	1	0	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:C1	R:R:Y182	5.38	0	No	No	0	4	0	1
L:L:R2	R:R:E194	8.14	3	Yes	Yes	0	6	0	1
L:L:R2	R:R:W195	5	3	Yes	No	0	2	0	1
L:L:R2	R:R:E198	9.3	3	Yes	No	0	4	0	1
L:L:P3	R:R:E198	17.29	3	No	No	0	4	0	1
L:L:R4	R:R:Y21	5.14	0	No	No	0	4	0	1
L:L:R4	R:R:Y271	4.12	0	No	Yes	0	4	0	1
L:L:L5	R:R:Y271	8.21	0	No	Yes	0	4	0	1
L:L:L5	R:R:F291	9.74	0	No	Yes	0	4	0	1
L:L:K8	R:R:Y93	9.55	0	No	No	0	4	0	1
L:L:P10	R:R:W85	16.21	0	Yes	Yes	0	6	0	1
L:L:P10	R:R:I109	10.16	0	Yes	No	0	6	0	1
L:L:P10	R:R:Y299	5.56	0	Yes	Yes	0	7	0	1
L:L:M11	R:R:Y264	9.58	0	No	Yes	0	6	0	1
L:L:P12	R:R:F110	7.22	1	Yes	Yes	0	5	0	1
L:L:P12	R:R:V164	7.07	1	Yes	No	0	4	0	1
L:L:P12	R:R:R168	5.76	1	Yes	Yes	0	5	0	1
L:L:P12	R:R:M183	8.39	1	Yes	Yes	0	5	0	1
L:L:F13	R:R:F110	8.57	1	No	Yes	0	5	0	1
L:L:F13	R:R:L201	10.96	1	No	No	0	4	0	1
R:R:D284	R:R:Y21	5.75	0	No	No	4	4	2	1
R:R:Y299	R:R:Y35	5.96	0	Yes	Yes	7	7	1	2
R:R:F78	R:R:W261	4.01	0	No	Yes	6	9	2	2
R:R:F78	R:R:Y299	8.25	0	No	Yes	6	7	2	1
R:R:L82	R:R:Y299	7.03	0	No	Yes	7	7	2	1
R:R:W85	R:R:Y88	6.75	1	Yes	Yes	6	5	1	2
R:R:W85	R:R:W95	12.18	1	Yes	Yes	6	8	1	2
R:R:S105	R:R:W85	4.94	0	No	Yes	5	6	2	1
R:R:R168	R:R:W85	5	1	Yes	Yes	5	6	1	1
R:R:C181	R:R:W85	6.53	1	Yes	Yes	9	6	2	1
R:R:Y88	R:R:Y93	9.93	1	Yes	No	5	4	2	1
R:R:W95	R:R:Y88	10.61	1	Yes	Yes	8	5	2	2
R:R:T89	R:R:Y93	4.99	0	No	No	5	4	2	1
R:R:C181	R:R:W95	13.06	1	Yes	Yes	9	8	2	2
R:R:R168	R:R:S106	9.22	1	Yes	No	5	5	1	2
R:R:V164	R:R:Y107	3.79	0	No	Yes	4	5	1	2
R:R:F110	R:R:Y114	9.28	1	Yes	Yes	5	6	1	2
R:R:A161	R:R:F110	4.16	0	No	Yes	7	5	2	1
R:R:F110	R:R:S205	3.96	1	Yes	No	5	4	1	2
R:R:S205	R:R:Y114	3.82	1	No	Yes	4	6	2	2
R:R:L167	R:R:M183	5.65	0	No	Yes	5	5	2	1
R:R:C181	R:R:R168	6.96	1	Yes	Yes	9	5	2	1
R:R:M183	R:R:R168	7.44	1	Yes	Yes	5	5	1	1
R:R:T169	R:R:Y182	8.74	0	No	No	4	4	2	1
R:R:G171	R:R:Y182	5.79	0	No	No	1	4	2	1
R:R:M183	R:R:Y185	10.78	1	Yes	No	5	5	1	2
R:R:E194	R:R:Y185	5.61	0	Yes	No	6	5	1	2
R:R:E194	R:R:V191	4.28	0	Yes	No	6	2	1	2
R:R:W261	R:R:Y264	3.86	0	Yes	Yes	9	6	2	1
R:R:H265	R:R:Y264	8.71	2	Yes	Yes	8	6	2	1
R:R:K268	R:R:Y264	5.97	2	No	Yes	5	6	2	1
R:R:F291	R:R:Y264	5.16	0	Yes	Yes	4	6	1	1
R:R:H265	R:R:K268	3.93	2	Yes	No	8	5	2	2
R:R:F291	R:R:V267	5.24	0	Yes	No	4	4	1	2
R:R:D284	R:R:Y271	4.6	0	No	Yes	4	4	2	1
R:R:M288	R:R:Y271	5.99	0	No	Yes	4	4	2	1
R:R:F291	R:R:T295	5.19	0	Yes	No	4	5	1	2
R:R:T295	R:R:Y299	6.24	0	No	Yes	5	7	2	1
R:R:V199	R:R:W195	3.68	0	No	No	3	2	2	1
R:R:L285	R:R:Y21	3.52	0	No	No	3	4	2	1
R:R:L201	R:R:W197	3.42	0	No	No	4	2	1	2
R:R:L201	R:R:P163	3.28	0	No	No	4	8	1	2
R:R:L276	R:R:S275	3	0	No	No	1	4	2	1
R:R:E194	R:R:S186	2.87	0	Yes	No	6	5	1	2
L:L:R2	R:R:S275	2.64	3	Yes	No	0	4	0	1
R:R:A196	R:R:W195	2.59	0	No	No	1	2	2	1
R:R:V38	R:R:Y299	2.52	0	No	Yes	7	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XZH_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.79
Number of Linked Nodes	294
Number of Links	315
Number of Hubs	38
Number of Links mediated by Hubs	141
Number of Communities	4
Number of Nodes involved in Communities	25
Number of Links involved in Communities	33

Path Summary
Number Of Nodes in MetaPath	101
Number Of Links MetaPath	100
Number of Shortest Paths	55550
Length Of Smallest Path	3
Average Path Length	13.4987
Length of Longest Path	30
Minimum Path Strength	1.33
Average Path Strength	6.61117
Maximum Path Strength	16.55
Minimum Path Correlation	0.7
Average Path Correlation	0.930964
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	52.3397
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.6261
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • apelin receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • developmental process • heart development • multicellular organism development • multicellular organismal process • anatomical structure development • animal organ development • circulatory system development • system development • atrioventricular valve development • heart valve development • cardiac chamber morphogenesis • heart morphogenesis • ventricular septum development • anatomical structure morphogenesis • cardiac septum development • cardiac septum morphogenesis • ventricular septum morphogenesis • cardiac chamber development • animal organ morphogenesis • cardiac ventricle development • regulation of body fluid levels • regulation of biological quality • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • tube morphogenesis • anatomical structure formation involved in morphogenesis • blood vessel development • regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis • positive regulation of cell population proliferation • endothelial cell proliferation • positive regulation of biological process • positive regulation of endothelial cell proliferation • epithelial cell proliferation • positive regulation of cellular process • positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis • cell population proliferation • blood vessel endothelial cell proliferation involved in sprouting angiogenesis • positive regulation of epithelial cell proliferation • sprouting angiogenesis • regulation of endothelial cell proliferation • regulation of cell population proliferation • regulation of epithelial cell proliferation • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • regulation of metabolic process • embryonic morphogenesis • embryo development • gastrulation • mesenchyme morphogenesis • endocardial cushion morphogenesis • mesenchyme development • tissue development • endocardial cushion formation • tissue morphogenesis • endocardial cushion development • artery development • aorta development • regulation of localization • negative adaptation of signaling pathway • regulation of G protein-coupled receptor internalization • receptor internalization • negative regulation of biological process • regulation of signal transduction • regulation of receptor internalization • vesicle-mediated transport • negative regulation of G protein-coupled receptor signaling pathway • localization • positive regulation of endocytosis • regulation of G protein-coupled receptor signaling pathway • positive regulation of receptor-mediated endocytosis • positive regulation of G protein-coupled receptor internalization • establishment of localization • positive regulation of receptor internalization • regulation of response to stimulus • adaptation of signaling pathway • receptor-mediated endocytosis • import into cell • regulation of cellular component organization • positive regulation of cellular component organization • transport • negative regulation of signaling • desensitization of G protein-coupled receptor signaling pathway • negative regulation of cell communication • cellular component organization • negative regulation of cellular process • cellular component organization or biogenesis • regulation of endocytosis • G protein-coupled receptor internalization • regulation of signaling • regulation of transport • negative regulation of response to stimulus • regulation of receptor-mediated endocytosis • regulation of vesicle-mediated transport • negative regulation of signal transduction • positive regulation of transport • regulation of cell communication • endocytosis • cellular developmental process • vasculogenesis • cell differentiation • regulation of developmental process • regulation of vasculature development • positive regulation of developmental process • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • positive regulation of angiogenesis • positive regulation of vasculature development • regulation of angiogenesis • positive regulation of multicellular organismal process • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • venous blood vessel development • regulation of calcium ion transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • intracellular calcium ion homeostasis • calcium ion transport • positive regulation of monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation homeostasis • monoatomic cation transport • intracellular monoatomic ion homeostasis • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • inorganic ion transmembrane transport • inorganic cation transmembrane transport • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • chemical homeostasis • cellular localization • inorganic ion homeostasis • homeostatic process • monoatomic ion transmembrane transport • calcium ion homeostasis • regulation of monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • metal ion transport • maintenance of location in cell • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • monoatomic ion transport • intracellular chemical homeostasis • positive regulation of release of sequestered calcium ion into cytosol • regulation of metal ion transport • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • sequestering of calcium ion • cellular homeostasis • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • negative regulation of muscle adaptation • system process • striated muscle adaptation • negative regulation of muscle hypertrophy • regulation of system process • regulation of muscle hypertrophy • regulation of cardiac muscle hypertrophy in response to stress • muscle adaptation • cardiac muscle adaptation • regulation of response to stress • response to stress • cardiac muscle hypertrophy • cardiac muscle hypertrophy in response to stress • muscle hypertrophy • regulation of muscle adaptation • negative regulation of cardiac muscle hypertrophy in response to stress • striated muscle hypertrophy • regulation of muscle system process • muscle system process • regulation of cardiac muscle hypertrophy • negative regulation of cardiac muscle adaptation • negative regulation of multicellular organismal process • regulation of cardiac muscle adaptation • negative regulation of cardiac muscle hypertrophy • muscle hypertrophy in response to stress • negative regulation of intracellular signal transduction • intracellular signal transduction • cAMP-mediated signaling • regulation of intracellular signal transduction • intracellular signaling cassette • negative regulation of cAMP-mediated signaling • regulation of cAMP-mediated signaling • adult heart development • negative regulation of metabolic process • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of macromolecule metabolic process • positive regulation of cardiac muscle hypertrophy • positive regulation of cardiac muscle hypertrophy in response to stress • positive regulation of response to stimulus • positive regulation of muscle adaptation • positive regulation of cardiac muscle adaptation • positive regulation of muscle hypertrophy • smooth muscle cell differentiation • muscle cell differentiation • muscle structure development • vascular associated smooth muscle cell differentiation • coronary vasculature development • gap junction assembly • regulation of gap junction assembly • regulation of cellular component biogenesis • cellular component biogenesis • regulation of cell junction assembly • cell junction organization • cellular component assembly • cell junction assembly • cell-cell junction assembly • cell-cell junction organization • pattern specification process • embryonic heart tube development • embryonic heart tube morphogenesis • heart looping • determination of bilateral symmetry • epithelial tube morphogenesis • embryonic organ development • determination of left/right symmetry • specification of symmetry • embryonic organ morphogenesis • epithelium development • morphogenesis of an epithelium • determination of heart left/right asymmetry • regionalization • left/right pattern formation • cell periphery • cellular anatomical structure • plasma membrane • membrane • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cell cycle • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • apelin receptor binding • neuropeptide receptor binding • molecular transducer activity • molecular function activator activity • signaling receptor activity • signaling receptor activator activity • hormone activity • signaling receptor regulator activity • receptor ligand activity • response to fibroblast growth factor • cellular response to growth factor stimulus • negative regulation of cellular response to growth factor stimulus • cell surface receptor protein tyrosine kinase signaling pathway • enzyme-linked receptor protein signaling pathway • negative regulation of fibroblast growth factor receptor signaling pathway • cell surface receptor signaling pathway • regulation of cellular response to growth factor stimulus • fibroblast growth factor receptor signaling pathway • response to growth factor • cellular response to fibroblast growth factor stimulus • regulation of fibroblast growth factor receptor signaling pathway • regulation of vascular endothelial cell proliferation • vascular endothelial cell proliferation • positive regulation of vascular endothelial cell proliferation • immune response • secretion • mammary gland development • gland development • body fluid secretion • lactation • heart process • regulation of heart contraction • positive regulation of blood circulation • positive regulation of heart contraction • circulatory system process • regulation of blood circulation • heart contraction • blood circulation • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of miRNA transcription • positive regulation of miRNA metabolic process • positive regulation of macromolecule biosynthetic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • DNA-templated transcription • nucleic acid biosynthetic process • regulation of RNA metabolic process • miRNA transcription • regulation of miRNA metabolic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • miRNA metabolic process • regulation of RNA biosynthetic process • positive regulation of nucleobase-containing compound metabolic process • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • regulation of miRNA transcription • behavior • drinking behavior • feeding behavior • regulation of vascular associated smooth muscle cell proliferation • negative regulation of cell population proliferation • regulation of smooth muscle cell proliferation • negative regulation of vascular associated smooth muscle cell proliferation • smooth muscle cell proliferation • negative regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • regulation of blood pressure • negative regulation of blood pressure
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35414
Sequence	>8XZH_nogp_Chain_R E C E Y T D W K S S G A L I P A I Y M L V F L L G T T G N G L V L W T V F R S R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D Y D W P F G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R P V A N A R L R L R V S G A V A T A V L W V L A A L L A M P V M V L R T T G D L E N T T K V Q C Y M D Y S M V A T V S S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R K E R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L L H W P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R F R Q A C T S M L C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8Z74	A	Peptide	Apelin	Apelin	Homo sapiens	Agonistic antibody	-	-	3.01	2025-01-22	10.1038/s41467-024-55555-6
	8XQJ	A	Peptide	Apelin	Apelin	Homo sapiens	JN241	-	-	2.95	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQI	A	Peptide	Apelin	Apelin	Homo sapiens	-	-	-	3.25	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8Z7J	A	Peptide	Apelin	Apelin	Homo sapiens	Agonistic antibody	-	Gi1/β1/γ2	3.12	2025-01-22	10.1038/s41467-024-55555-6
	8Z7J (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Agonistic antibody	-		3.12	2025-01-22	10.1038/s41467-024-55555-6
	8XQF	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-	Gi1/β1/γ2	3.13	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQF (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-		3.13	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQE	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-	Gi1/β1/γ2	3.48	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQE (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-		3.48	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8S4D	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-	-	2.58	2024-12-04	doi.org/10.1038/s41467-024-55381-w
	8XZJ	A	Peptide	Apelin	Apelin	Homo sapiens	WN353	-	Gi1/β1/γ2	3	2024-03-20	10.1016/j.cell.2024.02.004
	8XZJ (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	WN353	-		3	2024-03-20	10.1016/j.cell.2024.02.004
	8XZI	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-	Gi1/β1/γ2	2.7	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZI (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-		2.7	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZH	A	Peptide	Apelin	Apelin	Homo sapiens	MM07	-	Gi1/β1/γ2	2.06	2024-03-20	10.1016/j.cell.2024.02.004
	8XZH (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	MM07	-		2.06	2024-03-20	10.1016/j.cell.2024.02.004
	8XZG	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-	Gi1/β1/γ2	3.2	2024-03-20	10.1016/j.cell.2024.02.004
	8XZG (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-		3.2	2024-03-20	10.1016/j.cell.2024.02.004
	8XZF	A	Peptide	Apelin	Apelin	Homo sapiens	WN561	-	Gi1/β1/γ2	3	2024-03-20	10.1016/j.cell.2024.02.004
	8XZF (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	WN561	-		3	2024-03-20	10.1016/j.cell.2024.02.004
	7SUS	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-	-	2.7	2022-07-27	10.1038/s41594-022-00797-5
	7W0P	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-	Gi1/β1/γ2	3.16	2022-07-27	10.1038/s41594-022-00797-5
	7W0P (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-		3.16	2022-07-27	10.1038/s41594-022-00797-5
	7W0O	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-	Gi1/β1/γ2	3.78	2022-07-27	10.1038/s41594-022-00797-5
	7W0O (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-		3.78	2022-07-27	10.1038/s41594-022-00797-5
	7W0N	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-	Gi1/β1/γ2	4.21	2022-07-27	10.1038/s41594-022-00797-5
	7W0N (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-		4.21	2022-07-27	10.1038/s41594-022-00797-5
	7W0M	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-	Gi1/β1/γ2	3.71	2022-07-27	10.1038/s41594-022-00797-5
	7W0M (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-		3.71	2022-07-27	10.1038/s41594-022-00797-5
	7W0L	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-	Gi1/β1/γ2	3.57	2022-07-27	10.1038/s41594-022-00797-5
	7W0L (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-		3.57	2022-07-27	10.1038/s41594-022-00797-5
	6KNM	A	Peptide	Apelin	Apelin	Homo sapiens	JN241-9	-	-	3.2	2020-01-29	10.1126/sciadv.aax7379
	5VBL	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin mimetic peptide agonist	-	-	2.6	2017-05-31	10.1016/j.str.2017.04.008

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