psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N289	R:R:W24	19.21	No	No	0	2	1
2	R:R:W24	R:R:Y293	5.79	No	No	0	1	5
3	R:R:I31	R:R:Y35	7.25	Yes	Yes	1	6	7
4	R:R:I31	R:R:T89	4.56	Yes	No	0	6	5
5	R:R:I31	R:R:Y293	3.63	Yes	No	0	6	5
6	R:R:C296	R:R:I31	4.91	No	Yes	1	5	6
7	R:R:P32	R:R:T89	6.99	No	No	0	5	5
8	R:R:P32	R:R:Y90	5.56	No	No	0	5	3
9	R:R:A86	R:R:Y35	4	No	Yes	0	6	7
10	R:R:C296	R:R:Y35	5.38	No	Yes	1	5	7
11	R:R:Y299	R:R:Y35	11.91	Yes	Yes	1	7	7
12	R:R:F39	R:R:M36	4.98	Yes	No	0	6	3
13	R:R:V300	R:R:V38	4.81	No	No	0	5	7
14	R:R:C303	R:R:V38	10.25	No	No	0	7	7
15	R:R:F39	R:R:L40	3.65	Yes	No	0	6	5
16	R:R:F39	R:R:T43	3.89	Yes	No	0	6	5
17	R:R:F39	R:R:P83	15.89	Yes	No	0	6	9
18	R:R:F307	R:R:L41	6.09	No	No	0	6	5
19	R:R:G45	R:R:P306	4.06	No	No	0	8	9
20	R:R:D75	R:R:N46	6.73	Yes	No	0	9	9
21	R:R:L76	R:R:N46	6.87	No	No	0	7	9
22	R:R:N46	R:R:P306	6.52	No	No	0	9	9
23	R:R:F316	R:R:L48	8.53	Yes	No	0	9	5
24	R:R:V49	R:R:Y309	3.79	No	Yes	3	8	9
25	R:R:F316	R:R:V49	6.55	Yes	No	3	9	8
26	R:R:F54	R:R:L50	7.31	Yes	No	0	3	7
27	R:R:R55	R:R:W51	11	No	No	0	6	3
28	R:R:A319	R:R:W51	3.89	No	No	0	5	3
29	R:R:A319	R:R:T52	5.03	No	No	0	5	7
30	R:R:F54	R:R:V53	7.87	Yes	No	0	3	6
31	R:R:F54	R:R:R61	4.28	Yes	No	0	3	6
32	R:R:R55	R:R:S322	5.27	No	No	0	6	5
33	R:R:E59	R:R:S57	5.75	No	No	0	5	6
34	R:R:D65	R:R:R61	7.15	No	No	0	8	6
35	R:R:D65	R:R:R62	15.48	No	Yes	3	8	7
36	R:R:L246	R:R:R62	3.64	No	Yes	0	7	7
37	R:R:D313	R:R:R62	5.96	Yes	Yes	3	8	7
38	R:R:R315	R:R:R62	20.26	Yes	Yes	3	7	7
39	R:R:D126	R:R:S63	4.42	No	No	0	8	6
40	R:R:R141	R:R:S63	3.95	No	No	0	7	6
41	R:R:D65	R:R:R315	8.34	No	Yes	3	8	7
42	R:R:F67	R:R:I66	6.28	Yes	No	0	7	5
43	R:R:I66	R:R:T150	4.56	No	No	0	5	6
44	R:R:C119	R:R:F67	4.19	No	Yes	0	7	7
45	R:R:F67	R:R:G122	4.52	Yes	No	0	7	6
46	R:R:F67	R:R:L123	7.31	Yes	No	0	7	8
47	R:R:I68	R:R:Y309	13.3	No	Yes	0	8	9
48	R:R:C119	R:R:S70	5.16	No	No	0	7	9
49	R:R:S70	R:R:W154	6.18	No	Yes	0	9	9
50	R:R:L71	R:R:N305	5.49	No	Yes	0	9	9
51	R:R:V73	R:R:W154	3.68	No	Yes	0	5	9
52	R:R:D75	R:R:N112	5.39	Yes	Yes	0	9	8
53	R:R:D75	R:R:S302	5.89	Yes	No	0	9	8
54	R:R:D75	R:R:N305	4.04	Yes	Yes	0	9	9
55	R:R:F78	R:R:L82	6.09	Yes	No	0	6	7
56	R:R:F78	R:R:I109	6.28	Yes	No	1	6	6
57	R:R:F78	R:R:N112	12.08	Yes	Yes	0	6	8
58	R:R:F78	R:R:Y299	18.57	Yes	Yes	1	6	7
59	R:R:F78	R:R:S302	3.96	Yes	No	0	6	8
60	R:R:S105	R:R:T81	7.99	No	No	0	5	7
61	R:R:L84	R:R:W95	4.56	No	Yes	1	6	8
62	R:R:F97	R:R:L84	19.49	Yes	No	1	6	6
63	R:R:W85	R:R:Y88	6.75	Yes	Yes	1	6	5
64	R:R:W85	R:R:W95	8.43	Yes	Yes	1	6	8
65	R:R:S105	R:R:W85	4.94	No	Yes	1	5	6
66	R:R:I109	R:R:W85	5.87	No	Yes	1	6	6
67	R:R:C181	R:R:W85	5.22	Yes	Yes	1	9	6
68	R:R:F97	R:R:T87	5.19	Yes	No	0	6	4
69	R:R:Y88	R:R:Y93	7.94	Yes	No	0	5	4
70	R:R:W95	R:R:Y88	7.72	Yes	Yes	1	8	5
71	R:R:T89	R:R:Y93	3.75	No	No	0	5	4
72	R:R:D94	R:R:R91	13.1	No	No	0	4	3
73	R:R:P96	R:R:R91	12.97	No	No	0	4	3
74	R:R:D92	R:R:K178	4.15	No	No	0	6	2
75	R:R:F97	R:R:W95	15.03	Yes	Yes	1	6	8
76	R:R:C102	R:R:W95	5.22	Yes	Yes	1	9	8
77	R:R:S105	R:R:W95	3.71	No	Yes	1	5	8
78	R:R:V179	R:R:W95	4.9	No	Yes	0	5	8
79	R:R:C181	R:R:W95	3.92	Yes	Yes	1	9	8
80	R:R:F97	R:R:P96	8.67	Yes	No	0	6	4
81	R:R:F97	S:S:F101	6.43	Yes	No	0	6	5
82	R:R:K103	R:R:T99	4.5	No	No	0	7	3
83	R:R:T170	R:R:T99	7.85	No	No	0	5	3
84	R:R:F100	R:R:F101	12.86	No	No	0	1	5
85	R:R:F100	R:R:L104	3.65	No	No	0	1	5
86	R:R:F101	S:S:F97	6.43	No	Yes	0	5	6
87	R:R:F101	S:S:F101	19.29	No	No	0	5	5
88	R:R:C102	R:R:R168	4.18	Yes	Yes	1	9	5
89	R:R:C102	R:R:C181	7.28	Yes	Yes	1	9	9
90	R:R:L104	R:R:L108	4.15	No	No	0	5	4
91	R:R:R168	R:R:S106	17.13	Yes	No	0	5	5
92	R:R:V111	R:R:Y107	8.83	No	Yes	0	4	5
93	R:R:M162	R:R:Y107	4.79	No	Yes	0	4	5
94	R:R:M165	R:R:Y107	9.58	No	Yes	0	5	5
95	R:R:I109	R:R:Y299	6.04	No	Yes	1	6	7
96	R:R:F110	R:R:M113	4.98	Yes	No	0	5	7
97	R:R:F110	R:R:Y114	6.19	Yes	Yes	8	5	6
98	R:R:F110	R:R:V164	13.11	Yes	No	0	5	4
99	R:R:F110	R:R:S205	3.96	Yes	No	8	5	4
100	R:R:N112	R:R:S116	4.47	Yes	No	0	8	9
101	R:R:M113	R:R:W261	9.31	No	Yes	0	7	9
102	R:R:S205	R:R:Y114	3.82	No	Yes	8	4	6
103	R:R:V208	R:R:Y114	3.79	No	Yes	0	5	6
104	R:R:A115	R:R:W154	7.78	No	Yes	0	7	9
105	R:R:F118	R:R:V117	3.93	No	No	0	5	7
106	R:R:P213	R:R:V117	7.07	No	No	0	9	7
107	R:R:F257	R:R:V117	5.24	Yes	No	0	8	7
108	R:R:C119	R:R:L153	6.35	No	No	0	7	6
109	R:R:L120	R:R:V254	5.96	No	No	0	8	7
110	R:R:F257	R:R:L120	6.09	Yes	No	0	8	8
111	R:R:M217	R:R:T121	9.03	No	No	0	8	7
112	R:R:I250	R:R:L123	7.14	No	No	0	7	8
113	R:R:M217	R:R:S124	9.2	No	No	0	8	9
114	R:R:S124	R:R:Y221	10.17	No	No	0	9	8
115	R:R:F125	R:R:L129	8.53	No	No	0	6	5
116	R:R:D126	R:R:R127	3.57	No	Yes	0	8	9
117	R:R:L246	R:R:R127	9.72	No	Yes	0	7	9
118	R:R:I250	R:R:R127	3.76	No	Yes	0	7	9
119	R:R:V132	R:R:Y128	10.09	No	No	0	7	8
120	R:R:C220	R:R:Y128	5.38	No	No	0	6	8
121	R:R:F223	R:R:Y128	4.13	No	No	0	5	8
122	R:R:L129	R:R:N137	9.61	No	No	0	5	6
123	R:R:L129	R:R:L140	5.54	No	No	0	5	4
124	R:R:I131	R:R:I228	4.42	No	No	0	8	8
125	R:R:I131	R:R:R243	18.79	No	No	0	8	6
126	R:R:T227	R:R:V132	11.11	No	No	0	4	7
127	R:R:R133	R:R:V135	10.46	No	No	0	6	6
128	R:R:R139	R:R:V135	5.23	No	No	0	4	6
129	R:R:N137	R:R:R141	8.44	No	No	0	6	7
130	R:R:R139	R:R:R143	5.33	No	No	0	4	3
131	R:R:G146	R:R:S145	3.71	No	No	0	7	4
132	R:R:L153	R:R:W154	6.83	No	Yes	0	6	9
133	R:R:L160	R:R:V208	4.47	No	No	0	4	5
134	R:R:M183	R:R:V164	4.56	No	No	0	5	4
135	R:R:C181	R:R:R168	8.36	Yes	Yes	1	9	5
136	R:R:M183	R:R:R168	4.96	No	Yes	0	5	5
137	R:R:T169	R:R:Y182	7.49	No	Yes	9	4	4
138	R:R:D184	R:R:T169	5.78	No	No	9	3	4
139	R:R:D172	R:R:V179	5.84	No	No	0	1	5
140	R:R:L173	R:R:Q180	13.31	No	No	0	3	2
141	R:R:L173	R:R:Y182	5.86	No	Yes	0	3	4
142	R:R:E174	R:R:Q180	11.47	No	No	0	2	2
143	R:R:K178	R:R:T176	7.51	No	No	0	2	3
144	R:R:D184	R:R:Y182	11.49	No	Yes	9	3	4
145	R:R:M183	R:R:Y185	8.38	No	Yes	0	5	5
146	R:R:D184	R:R:S186	4.42	No	No	0	3	5
147	R:R:E194	R:R:Y185	8.98	No	Yes	0	6	5
148	R:R:E198	R:R:Y185	10.1	No	Yes	0	4	5
149	R:R:V188	R:R:W197	17.16	No	No	0	2	2
150	R:R:A189	R:R:W197	5.19	No	No	0	1	2
151	R:R:S192	R:R:T190	4.8	No	No	0	2	1
152	R:R:L201	R:R:W197	6.83	No	No	0	4	2
153	R:R:H265	R:R:T206	5.48	Yes	No	0	8	5
154	R:R:T206	R:R:T269	4.71	No	No	0	5	6
155	R:R:F210	R:R:F214	13.93	No	No	0	8	6
156	R:R:F210	R:R:M262	11.2	No	No	0	8	5
157	R:R:F210	R:R:H265	15.84	No	Yes	0	8	8
158	R:R:F214	R:R:M217	3.73	No	No	0	6	8
159	R:R:V251	R:R:Y221	3.79	No	No	0	3	8
160	R:R:V254	R:R:Y221	8.83	No	No	0	7	8
161	R:R:I224	R:R:L247	4.28	No	No	0	8	6
162	R:R:H231	R:R:T227	8.21	No	No	0	5	4
163	R:R:H231	R:R:I228	3.98	No	No	0	5	8
164	R:R:F232	R:R:I228	6.28	No	No	0	4	8
165	R:R:H231	R:R:R243	4.51	No	No	0	5	6
166	R:R:R241	R:R:R244	13.86	No	No	10	4	5
167	R:R:R241	R:R:R245	18.13	No	No	10	4	7
168	R:R:R244	R:R:R245	7.46	No	No	10	5	7
169	R:R:I249	R:R:L253	7.14	No	Yes	3	7	7
170	R:R:I249	R:R:Y309	4.84	No	Yes	3	7	9
171	R:R:F312	R:R:V252	10.49	No	No	0	6	5
172	R:R:L253	R:R:N305	5.49	Yes	Yes	3	7	9
173	R:R:L253	R:R:Y309	9.38	Yes	Yes	3	7	9
174	R:R:L308	R:R:T256	7.37	No	No	0	8	6
175	R:R:F257	R:R:W261	20.04	Yes	Yes	0	8	9
176	R:R:F257	R:R:N301	6.04	Yes	No	0	8	9
177	R:R:C260	R:R:N301	9.45	No	No	0	7	9
178	R:R:W261	R:R:Y264	6.75	Yes	Yes	5	9	6
179	R:R:H265	R:R:W261	8.46	Yes	Yes	5	8	9
180	R:R:S298	R:R:W261	9.88	No	Yes	0	7	9
181	R:R:C294	R:R:P263	3.77	No	No	0	6	9
182	R:R:H265	R:R:Y264	7.62	Yes	Yes	5	8	6
183	R:R:K268	R:R:Y264	9.55	No	Yes	5	5	6
184	R:R:F291	R:R:Y264	5.16	Yes	Yes	0	4	6
185	R:R:H265	R:R:K268	3.93	Yes	No	5	8	5
186	R:R:L287	R:R:V267	4.47	No	No	0	4	4
187	R:R:F291	R:R:V267	5.24	Yes	No	0	4	4
188	R:R:L273	R:R:T269	4.42	No	No	0	4	6
189	R:R:L270	R:R:W279	6.83	No	Yes	0	5	1
190	R:R:M288	R:R:Y271	8.38	No	No	0	4	4
191	R:R:L273	R:R:W279	4.56	No	Yes	0	4	1
192	R:R:G274	R:R:W279	9.85	No	Yes	0	3	1
193	R:R:L277	R:R:W279	6.83	No	Yes	0	1	1
194	R:R:F283	R:R:W279	5.01	No	Yes	0	3	1
195	R:R:F283	R:R:L287	10.96	No	No	0	3	4
196	R:R:L285	R:R:N289	9.61	No	No	0	3	2
197	R:R:F286	R:R:I290	3.77	No	No	0	1	4
198	R:R:F291	R:R:T295	5.19	Yes	No	0	4	5
199	R:R:T295	R:R:Y299	6.24	No	Yes	0	5	7
200	R:R:S298	R:R:Y299	5.09	No	Yes	0	7	7
201	R:R:L304	R:R:V300	4.47	No	No	0	6	5
202	R:R:N305	R:R:Y309	5.81	Yes	Yes	3	9	9
203	R:R:F316	R:R:Y309	4.13	Yes	Yes	3	9	9
204	R:R:F311	R:R:F312	11.79	No	No	0	6	6
205	R:R:D313	R:R:P314	4.83	Yes	No	0	8	5
206	R:R:D313	R:R:R315	7.15	Yes	Yes	3	8	7
207	R:R:D313	R:R:F316	3.58	Yes	Yes	3	8	9
208	R:R:Q318	R:R:T321	4.25	No	No	0	6	4
209	R:R:Q318	R:R:S322	7.22	No	No	0	6	5
210	S:S:D282	S:S:E18	7.8	No	No	0	2	5
211	S:S:C19	S:S:E20	7.6	No	No	0	8	5
212	S:S:C19	S:S:C281	7.28	No	No	0	8	8
213	S:S:C19	S:S:L285	6.35	No	No	0	8	3
214	S:S:T22	S:S:Y21	13.73	No	No	0	4	4
215	S:S:D23	S:S:T22	4.34	No	No	0	5	4
216	S:S:F286	S:S:W24	5.01	No	No	11	1	1
217	S:S:N289	S:S:W24	21.47	No	No	0	2	1
218	S:S:I290	S:S:W24	8.22	No	No	11	4	1
219	S:S:L30	S:S:S27	6.01	No	No	0	5	3
220	S:S:I31	S:S:S27	6.19	No	No	0	6	3
221	S:S:S27	S:S:Y293	6.36	No	No	0	3	5
222	S:S:I31	S:S:P32	5.08	No	No	0	6	5
223	S:S:I31	S:S:Y35	6.04	No	Yes	0	6	7
224	S:S:P32	S:S:T89	6.99	No	No	0	5	5
225	S:S:P32	S:S:Y90	5.56	No	No	0	5	3
226	S:S:A86	S:S:Y35	4	No	Yes	0	6	7
227	S:S:T89	S:S:Y35	3.75	No	Yes	0	5	7
228	S:S:Y299	S:S:Y35	8.94	Yes	Yes	0	7	7
229	S:S:M36	S:S:P83	5.03	No	No	0	3	9
230	S:S:C303	S:S:V38	8.54	No	No	0	7	7
231	S:S:F39	S:S:P83	15.89	No	No	0	6	9
232	S:S:F307	S:S:L41	7.31	No	No	0	6	5
233	S:S:G45	S:S:P306	4.06	No	No	0	8	9
234	S:S:D75	S:S:N46	9.42	Yes	Yes	0	9	9
235	S:S:L76	S:S:N46	4.12	No	Yes	0	7	9
236	S:S:N46	S:S:P306	6.52	Yes	No	0	9	9
237	S:S:L48	S:S:W51	4.56	No	No	0	5	3
238	S:S:F316	S:S:L48	7.31	Yes	No	0	9	5
239	S:S:F316	S:S:V49	6.55	Yes	No	0	9	8
240	S:S:F54	S:S:L50	8.53	No	Yes	0	3	7
241	S:S:T52	S:S:W51	4.85	Yes	No	6	7	3
242	S:S:R55	S:S:W51	12	Yes	No	6	6	3
243	S:S:R55	S:S:T52	3.88	Yes	Yes	6	6	7
244	S:S:F316	S:S:T52	5.19	Yes	Yes	0	9	7
245	S:S:A319	S:S:T52	5.03	No	Yes	6	5	7
246	S:S:F54	S:S:V53	3.93	No	No	0	3	6
247	S:S:A319	S:S:R55	4.15	No	Yes	6	5	6
248	S:S:R55	S:S:S322	5.27	Yes	No	0	6	5
249	S:S:R58	S:S:R61	5.33	No	No	0	6	6
250	S:S:K60	S:S:R315	3.71	No	Yes	0	6	7
251	S:S:D65	S:S:R61	4.76	No	No	0	8	6
252	S:S:D65	S:S:R62	21.44	No	Yes	7	8	7
253	S:S:L246	S:S:R62	8.5	No	Yes	0	7	7
254	S:S:D313	S:S:R62	5.96	Yes	Yes	7	8	7
255	S:S:R315	S:S:R62	19.19	Yes	Yes	7	7	7
256	S:S:D126	S:S:S63	7.36	No	No	0	8	6
257	S:S:D65	S:S:R315	5.96	No	Yes	7	8	7
258	S:S:I66	S:S:T150	9.12	No	No	0	5	6
259	S:S:F67	S:S:L123	7.31	No	No	0	7	8
260	S:S:F67	S:S:T150	3.89	No	No	0	7	6
261	S:S:I68	S:S:Y309	10.88	No	Yes	0	8	9
262	S:S:S70	S:S:W154	7.41	No	Yes	0	9	9
263	S:S:V73	S:S:W154	3.68	No	Yes	0	5	9
264	S:S:D75	S:S:N112	4.04	Yes	Yes	2	9	8
265	S:S:D75	S:S:S302	10.31	Yes	No	2	9	8
266	S:S:D75	S:S:N305	6.73	Yes	No	0	9	9
267	S:S:F78	S:S:L82	7.31	Yes	No	0	6	7
268	S:S:F78	S:S:I109	7.54	Yes	No	2	6	6
269	S:S:F78	S:S:N112	9.67	Yes	Yes	2	6	8
270	S:S:F78	S:S:Y299	18.57	Yes	Yes	2	6	7
271	S:S:F78	S:S:S302	3.96	Yes	No	2	6	8
272	S:S:L84	S:S:W95	4.56	No	Yes	2	6	8
273	S:S:F97	S:S:L84	19.49	Yes	No	2	6	6
274	S:S:W85	S:S:Y88	6.75	Yes	No	2	6	5
275	S:S:W85	S:S:W95	9.37	Yes	Yes	2	6	8
276	S:S:S105	S:S:W85	9.88	No	Yes	2	5	6
277	S:S:I109	S:S:W85	7.05	No	Yes	2	6	6
278	S:S:F97	S:S:T87	6.49	Yes	No	0	6	4
279	S:S:Y88	S:S:Y93	6.95	No	No	0	5	4
280	S:S:W95	S:S:Y88	9.65	Yes	No	2	8	5
281	S:S:T89	S:S:Y93	3.75	No	No	0	5	4
282	S:S:D94	S:S:R91	11.91	No	No	0	4	3
283	S:S:P96	S:S:R91	14.41	No	No	0	4	3
284	S:S:D92	S:S:K178	8.3	No	No	0	6	2
285	S:S:D94	S:S:K178	4.15	No	No	0	4	2
286	S:S:F97	S:S:W95	15.03	Yes	Yes	2	6	8
287	S:S:C102	S:S:W95	5.22	No	Yes	2	9	8
288	S:S:S105	S:S:W95	4.94	No	Yes	2	5	8
289	S:S:T170	S:S:W95	3.64	No	Yes	0	5	8
290	S:S:C181	S:S:W95	5.22	No	Yes	2	9	8
291	S:S:F97	S:S:P96	10.11	Yes	No	0	6	4
292	S:S:K103	S:S:T99	4.5	No	No	0	7	3
293	S:S:T170	S:S:T99	7.85	No	No	0	5	3
294	S:S:F100	S:S:F101	12.86	No	No	0	1	5
295	S:S:F100	S:S:L104	3.65	No	No	0	1	5
296	S:S:C102	S:S:R168	6.96	No	Yes	2	9	5
297	S:S:C102	S:S:C181	7.28	No	No	2	9	9
298	S:S:K103	S:S:R168	3.71	No	Yes	0	7	5
299	S:S:L104	S:S:L108	4.15	No	No	0	5	4
300	S:S:S106	S:S:V164	4.85	No	No	0	5	4
301	S:S:R168	S:S:S106	14.5	Yes	No	0	5	5
302	S:S:V111	S:S:Y107	8.83	No	Yes	0	4	5
303	S:S:A161	S:S:Y107	5.34	No	Yes	0	7	5
304	S:S:M162	S:S:Y107	3.59	No	Yes	0	4	5
305	S:S:M165	S:S:Y107	13.17	No	Yes	0	5	5
306	S:S:I109	S:S:Y299	7.25	No	Yes	2	6	7
307	S:S:F110	S:S:M113	3.73	Yes	No	0	5	7
308	S:S:F110	S:S:Y114	7.22	Yes	Yes	12	5	6
309	S:S:F110	S:S:V164	14.42	Yes	No	0	5	4
310	S:S:F110	S:S:S205	5.28	Yes	No	12	5	4
311	S:S:N112	S:S:S116	4.47	Yes	No	0	8	9
312	S:S:N112	S:S:S302	4.47	Yes	No	2	8	8
313	S:S:M113	S:S:W261	8.14	No	Yes	0	7	9
314	S:S:F118	S:S:Y114	5.16	Yes	Yes	0	5	6
315	S:S:L160	S:S:Y114	7.03	No	Yes	0	4	6
316	S:S:S205	S:S:Y114	5.09	No	Yes	12	4	6
317	S:S:V208	S:S:Y114	6.31	No	Yes	0	5	6
318	S:S:A115	S:S:W154	7.78	No	Yes	0	7	9
319	S:S:F118	S:S:V117	3.93	Yes	No	0	5	7
320	S:S:P213	S:S:V117	7.07	No	No	0	9	7
321	S:S:F257	S:S:V117	5.24	Yes	No	0	8	7
322	S:S:F118	S:S:L153	4.87	Yes	No	0	5	6
323	S:S:L120	S:S:V254	5.96	No	No	0	8	7
324	S:S:F257	S:S:L120	6.09	Yes	No	0	8	8
325	S:S:I216	S:S:T121	4.56	No	No	0	6	7
326	S:S:M217	S:S:T121	9.03	No	No	0	8	7
327	S:S:I250	S:S:L123	8.56	No	No	0	7	8
328	S:S:M217	S:S:S124	7.67	No	No	0	8	9
329	S:S:S124	S:S:Y221	5.09	No	Yes	0	9	8
330	S:S:F125	S:S:L129	4.87	No	Yes	0	6	5
331	S:S:C220	S:S:F125	5.59	No	No	0	6	6
332	S:S:D126	S:S:R127	3.57	No	No	0	8	9
333	S:S:D126	S:S:L129	4.07	No	Yes	0	8	5
334	S:S:A130	S:S:R127	5.53	No	No	0	8	9
335	S:S:L246	S:S:R127	10.93	No	No	0	7	9
336	S:S:V132	S:S:Y128	12.62	No	Yes	0	7	8
337	S:S:R133	S:S:Y128	12.35	No	Yes	0	6	8
338	S:S:C220	S:S:Y128	8.06	No	Yes	0	6	8
339	S:S:F223	S:S:Y128	8.25	Yes	Yes	0	5	8
340	S:S:I224	S:S:Y128	3.63	No	Yes	0	8	8
341	S:S:L129	S:S:N137	4.12	Yes	No	0	5	6
342	S:S:L129	S:S:L140	4.15	Yes	No	0	5	4
343	S:S:I131	S:S:I224	4.42	No	No	0	8	8
344	S:S:I131	S:S:R243	7.52	No	No	0	8	6
345	S:S:T227	S:S:V132	6.35	No	No	0	4	7
346	S:S:R139	S:S:V135	6.54	No	No	0	4	6
347	S:S:A136	S:S:R139	5.53	No	No	0	4	4
348	S:S:R139	S:S:R143	5.33	No	No	0	4	3
349	S:S:L140	S:S:R143	6.07	No	No	0	4	3
350	S:S:G146	S:S:S145	3.71	No	Yes	0	7	4
351	S:S:L153	S:S:W154	4.56	No	Yes	0	6	9
352	S:S:M183	S:S:V164	4.56	No	No	0	5	4
353	S:S:L167	S:S:M187	4.24	No	No	0	5	2
354	S:S:L167	S:S:V188	4.47	No	No	0	5	2
355	S:S:C181	S:S:R168	5.57	No	Yes	2	9	5
356	S:S:M183	S:S:R168	11.17	No	Yes	0	5	5
357	S:S:D184	S:S:T169	4.34	Yes	No	0	3	4
358	S:S:D172	S:S:V179	7.3	No	No	0	1	5
359	S:S:L173	S:S:Q180	7.99	No	No	0	3	2
360	S:S:L173	S:S:Y182	11.72	No	No	0	3	4
361	S:S:E174	S:S:Q180	3.82	No	No	0	2	2
362	S:S:M183	S:S:Y185	8.38	No	Yes	0	5	5
363	S:S:D184	S:S:S186	8.83	Yes	No	0	3	5
364	S:S:D184	S:S:M187	4.16	Yes	No	0	3	2
365	S:S:E194	S:S:Y185	10.1	No	Yes	0	6	5
366	S:S:E198	S:S:Y185	10.1	No	Yes	0	4	5
367	S:S:L201	S:S:Y185	5.86	No	Yes	0	4	5
368	S:S:V188	S:S:W197	22.07	No	No	0	2	2
369	S:S:A189	S:S:W197	5.19	No	No	0	1	2
370	S:S:L201	S:S:W197	6.83	No	No	0	4	2
371	S:S:H265	S:S:T206	4.11	Yes	No	0	8	5
372	S:S:T206	S:S:T269	4.71	No	No	0	5	6
373	S:S:F210	S:S:F214	15	No	Yes	0	8	6
374	S:S:F210	S:S:M262	8.71	No	No	0	8	5
375	S:S:F210	S:S:H265	13.58	No	Yes	0	8	8
376	S:S:F214	S:S:M217	6.22	Yes	No	0	6	8
377	S:S:F214	S:S:F257	4.29	Yes	Yes	0	6	8
378	S:S:I250	S:S:Y221	3.63	No	Yes	0	7	8
379	S:S:V251	S:S:Y221	3.79	No	Yes	0	3	8
380	S:S:V254	S:S:Y221	10.09	No	Yes	0	7	8
381	S:S:F232	S:S:H231	15.84	No	No	0	4	5
382	S:S:F232	S:S:R236	6.41	No	No	0	4	2
383	S:S:K234	S:S:R236	4.95	No	No	0	3	2
384	S:S:D313	S:S:R245	5.96	Yes	No	0	8	7
385	S:S:P314	S:S:R245	8.65	No	No	0	5	7
386	S:S:I249	S:S:Y309	4.84	Yes	Yes	0	7	9
387	S:S:F312	S:S:I249	5.02	No	Yes	0	6	7
388	S:S:D313	S:S:I249	4.2	Yes	Yes	0	8	7
389	S:S:F312	S:S:V252	9.18	No	No	0	6	5
390	S:S:L253	S:S:N305	4.12	No	No	0	7	9
391	S:S:L253	S:S:Y309	9.38	No	Yes	0	7	9
392	S:S:L308	S:S:T256	4.42	No	No	0	8	6
393	S:S:F257	S:S:W261	20.04	Yes	Yes	4	8	9
394	S:S:F257	S:S:N301	6.04	Yes	Yes	4	8	9
395	S:S:C260	S:S:N301	9.45	No	Yes	0	7	9
396	S:S:W261	S:S:Y264	3.86	Yes	Yes	4	9	6
397	S:S:H265	S:S:W261	7.41	Yes	Yes	4	8	9
398	S:S:S298	S:S:W261	12.36	No	Yes	0	7	9
399	S:S:N301	S:S:W261	5.65	Yes	Yes	4	9	9
400	S:S:C294	S:S:P263	3.77	No	No	0	6	9
401	S:S:H265	S:S:Y264	7.62	Yes	Yes	4	8	6
402	S:S:K268	S:S:Y264	4.78	No	Yes	0	5	6
403	S:S:F291	S:S:Y264	5.16	No	Yes	0	4	6
404	S:S:L266	S:S:L270	4.15	No	No	0	6	5
405	S:S:L287	S:S:V267	7.45	Yes	No	0	4	4
406	S:S:F291	S:S:V267	7.87	No	No	0	4	4
407	S:S:L287	S:S:Y271	5.86	Yes	No	0	4	4
408	S:S:M288	S:S:Y271	4.79	No	No	0	4	4
409	S:S:L273	S:S:L277	4.15	No	No	0	4	1
410	S:S:G274	S:S:W279	4.22	No	Yes	0	3	1
411	S:S:L276	S:S:S275	4.5	No	No	0	1	4
412	S:S:P280	S:S:W279	5.4	No	Yes	0	4	1
413	S:S:F283	S:S:W279	14.03	No	Yes	0	3	1
414	S:S:D284	S:S:W279	5.58	No	Yes	0	4	1
415	S:S:F283	S:S:L287	12.18	No	Yes	0	3	4
416	S:S:L285	S:S:N289	8.24	No	No	0	3	2
417	S:S:F286	S:S:L287	3.65	No	Yes	0	1	4
418	S:S:F286	S:S:I290	3.77	No	No	11	1	4
419	S:S:T295	S:S:Y299	7.49	No	Yes	0	5	7
420	S:S:S298	S:S:Y299	5.09	No	Yes	0	7	7
421	S:S:N301	S:S:N305	6.81	Yes	No	0	9	9
422	S:S:F316	S:S:Y309	5.16	Yes	Yes	0	9	9
423	S:S:D313	S:S:R315	7.15	Yes	Yes	7	8	7
424	R:R:P213	R:R:V212	3.53	No	No	0	9	6
425	S:S:P213	S:S:V212	3.53	No	No	0	9	6
426	R:R:L201	R:R:Y185	3.52	No	Yes	0	4	5
427	R:R:L287	R:R:Y271	3.52	No	No	0	4	4
428	R:R:G202	R:R:M272	3.49	No	No	0	5	5
429	S:S:G202	S:S:K268	3.49	No	No	0	5	5
430	S:S:G202	S:S:M272	3.49	No	No	0	5	5
431	S:S:E238	S:S:R244	3.49	No	No	0	4	5
432	S:S:D184	S:S:Y182	3.45	Yes	No	0	3	4
433	S:S:C119	S:S:S70	3.44	No	No	0	7	9
434	R:R:A189	R:R:S193	3.42	No	No	0	1	4
435	R:R:C294	R:R:V267	3.42	No	No	0	6	4
436	S:S:L276	S:S:W195	3.42	No	No	0	1	2
437	S:S:L273	S:S:W279	3.42	No	Yes	0	4	1
438	S:S:G42	S:S:N46	3.39	No	Yes	0	8	9
439	R:R:C102	R:R:T170	3.38	Yes	No	0	9	5
440	S:S:M262	S:S:P263	3.35	No	No	0	5	9
441	R:R:C296	R:R:I34	3.27	No	No	0	5	5
442	R:R:C260	R:R:I297	3.27	No	No	0	7	6
443	R:R:C294	R:R:I290	3.27	No	No	0	6	4
444	S:S:C296	S:S:I34	3.27	No	No	0	5	5
445	S:S:E238	S:S:G239	3.27	No	No	0	4	4
446	S:S:C260	S:S:I297	3.27	No	No	0	7	6
447	R:R:S302	R:R:V79	3.23	No	No	0	8	6
448	S:S:S145	S:S:V148	3.23	Yes	No	0	4	3
449	R:R:A86	R:R:M36	3.22	No	No	0	6	3
450	S:S:A86	S:S:M36	3.22	No	No	0	6	3
451	S:S:V300	S:S:V38	3.21	No	No	0	5	7
452	S:S:S105	S:S:T81	3.2	No	No	0	5	7
453	S:S:S193	S:S:T190	3.2	No	No	0	4	1
454	S:S:T43	S:S:V79	3.17	No	No	0	5	6
455	S:S:T170	S:S:V179	3.17	No	No	0	5	5
456	R:R:A72	R:R:L50	3.15	No	No	0	8	7
457	R:R:A64	R:R:L246	3.15	No	No	0	8	7
458	S:S:A72	S:S:L50	3.15	No	Yes	0	8	7
459	S:S:A64	S:S:L246	3.15	No	No	0	8	7
460	R:R:A74	R:R:N112	3.13	No	Yes	0	8	8
461	R:R:C281	R:R:D282	3.11	No	No	0	8	2
462	R:R:I224	R:R:V132	3.07	No	No	0	8	7
463	R:R:K60	R:R:S56	3.06	No	No	0	6	5
464	S:S:K60	S:S:S56	3.06	No	No	0	6	5
465	S:S:K60	S:S:S57	3.06	No	No	0	6	6
466	R:R:I216	R:R:T121	3.04	No	No	0	6	7
467	R:R:M162	R:R:V166	3.04	No	No	0	4	4
468	R:R:I216	R:R:T219	3.04	No	No	0	6	4
469	S:S:C281	S:S:E18	3.04	No	No	0	8	5
470	S:S:F67	S:S:G122	3.01	No	No	0	7	6
471	R:R:L30	R:R:S27	3	No	No	0	5	3
472	R:R:L276	R:R:S275	3	No	No	0	1	4
473	S:S:L71	S:S:S116	3	No	No	0	9	9
474	S:S:K178	S:S:T176	3	No	No	0	2	3
475	R:R:L82	R:R:V38	2.98	No	No	0	7	7
476	R:R:L247	R:R:V251	2.98	No	No	0	6	3
477	R:R:L308	R:R:V252	2.98	No	No	0	8	5
478	R:R:L259	R:R:V255	2.98	No	No	0	5	4
479	S:S:L82	S:S:V38	2.98	No	No	0	7	7
480	S:S:L50	S:S:V73	2.98	Yes	No	0	7	5
481	S:S:L167	S:S:V166	2.98	No	No	0	5	4
482	S:S:L247	S:S:V251	2.98	No	No	0	6	3
483	S:S:L308	S:S:V252	2.98	No	No	0	8	5
484	R:R:L108	R:R:T77	2.95	No	No	0	4	7
485	S:S:L76	S:S:T43	2.95	No	No	0	7	5
486	S:S:L108	S:S:T77	2.95	No	No	0	4	7
487	S:S:I224	S:S:I228	2.94	No	No	0	8	8
488	R:R:G209	R:R:Y114	2.9	No	Yes	0	5	6
489	R:R:G171	R:R:Y182	2.9	No	Yes	0	1	4
490	S:S:G209	S:S:Y114	2.9	No	Yes	0	5	6
491	R:R:P134	R:R:R133	2.88	No	No	0	8	6
492	R:R:P134	R:R:R243	2.88	No	No	0	8	6
493	R:R:K268	R:R:M272	2.88	No	No	0	5	5
494	S:S:E59	S:S:S57	2.87	No	No	0	5	6
495	R:R:I34	R:R:L30	2.85	No	No	0	5	5
496	R:R:L167	R:R:M187	2.83	No	No	0	5	2
497	S:S:Q318	S:S:T321	2.83	No	No	0	6	4
498	R:R:E174	R:R:T176	2.82	No	No	0	2	3
499	S:S:K242	S:S:L240	2.82	No	No	0	5	4
500	R:R:G98	R:R:W95	2.81	No	Yes	0	8	8
501	S:S:G98	S:S:W95	2.81	No	Yes	0	8	8
502	R:R:C320	R:R:F316	2.79	No	Yes	0	6	9
503	S:S:P292	S:S:Y93	2.78	No	No	0	4	4
504	R:R:A69	R:R:F54	2.77	No	Yes	0	5	3
505	R:R:A157	R:R:F118	2.77	No	No	0	7	5
506	R:R:A130	R:R:R127	2.77	No	Yes	0	8	9
507	R:R:A136	R:R:R139	2.77	No	No	0	4	4
508	R:R:A258	R:R:F214	2.77	No	No	0	5	6
509	R:R:L253	R:R:L308	2.77	Yes	No	0	7	8
510	R:R:L266	R:R:L270	2.77	No	No	0	6	5
511	R:R:L276	R:R:L277	2.77	No	No	0	1	1
512	R:R:A310	R:R:F316	2.77	No	Yes	0	6	9
513	S:S:A69	S:S:F54	2.77	No	No	0	5	3
514	S:S:A157	S:S:F118	2.77	No	Yes	0	7	5
515	S:S:A258	S:S:F214	2.77	No	Yes	0	5	6
516	S:S:A310	S:S:F316	2.77	No	Yes	0	6	9
517	R:R:P280	R:R:W279	2.7	No	Yes	0	4	1
518	S:S:D23	S:S:N289	2.69	No	No	0	5	2
519	S:S:C296	S:S:Y35	2.69	No	Yes	0	5	7
520	R:R:A29	R:R:Y90	2.67	No	No	0	3	3
521	R:R:A158	R:R:Y107	2.67	No	Yes	0	4	5
522	R:R:A161	R:R:Y107	2.67	No	Yes	0	7	5
523	R:R:A161	R:R:Y114	2.67	No	Yes	0	7	6
524	S:S:A158	S:S:Y107	2.67	No	Yes	0	4	5
525	R:R:R244	R:R:S248	2.64	No	No	0	5	6
526	S:S:R141	S:S:S145	2.64	No	Yes	0	7	4
527	S:S:R244	S:S:S248	2.64	No	No	0	5	6
528	R:R:F316	R:R:T52	2.59	Yes	No	0	9	7
529	R:R:A196	R:R:W195	2.59	No	No	0	1	2
530	S:S:A74	S:S:W154	2.59	No	Yes	0	8	9
531	S:S:A196	S:S:W195	2.59	No	No	0	1	2
532	S:S:F223	S:S:T219	2.59	Yes	No	0	5	4
533	S:S:F232	S:S:I228	2.51	No	No	0	4	8
534	R:R:K60	R:R:R315	2.48	No	Yes	0	6	7
535	S:S:V111	S:S:W154	2.45	No	Yes	0	4	9
536	R:R:D284	R:R:F283	2.39	No	No	0	4	3
537	R:R:L167	R:R:Y185	2.34	No	Yes	0	5	5
538	S:S:F223	S:S:Q226	2.34	Yes	No	0	5	3
539	R:R:K25	R:R:W24	2.32	No	No	0	4	1
540	R:R:L276	R:R:W195	2.28	No	No	0	1	2
541	S:S:L270	S:S:W279	2.28	No	Yes	0	5	1
542	R:R:Q180	R:R:Y88	2.25	No	Yes	0	2	5
543	S:S:F222	S:S:F223	2.14	No	Yes	0	3	5
544	S:S:F311	S:S:F312	2.14	No	No	0	6	6
545	R:R:C303	R:R:G42	1.96	No	No	0	7	8
546	R:R:A149	R:R:G146	1.95	No	No	0	5	7
547	R:R:A229	R:R:G230	1.95	No	No	0	4	4
548	S:S:A149	S:S:G146	1.95	No	No	0	5	7
549	R:R:G28	R:R:S27	1.86	No	No	0	3	3
550	R:R:G200	R:R:S204	1.86	No	No	0	2	4
551	S:S:G171	S:S:V179	1.84	No	No	0	1	5
552	R:R:G45	R:R:T44	1.82	No	No	0	8	4
553	S:S:G45	S:S:T44	1.82	No	No	0	8	4
554	R:R:G146	R:R:I66	1.76	No	No	0	7	5
555	R:R:G47	R:R:L50	1.71	No	No	0	3	7
556	R:R:A147	R:R:S145	1.71	No	No	0	4	4
557	S:S:G42	S:S:L41	1.71	No	No	0	8	5
558	S:S:G47	S:S:L50	1.71	No	Yes	0	3	7
559	S:S:G47	S:S:L76	1.71	No	No	0	3	7
560	S:S:A147	S:S:S145	1.71	No	Yes	0	4	4
561	S:S:A149	S:S:V144	1.7	No	No	0	5	4
562	R:R:M162	R:R:P163	1.68	No	No	0	4	8
563	S:S:M162	S:S:P163	1.68	No	No	0	4	8
564	R:R:S192	R:R:S193	1.63	No	No	0	2	4
565	S:S:S192	S:S:S193	1.63	No	No	0	2	4
566	S:S:A147	S:S:I66	1.62	No	No	0	4	5
567	R:R:V144	R:R:V148	1.6	No	No	0	4	3
568	R:R:V148	R:R:V152	1.6	No	No	0	3	2
569	R:R:V152	R:R:V155	1.6	No	No	0	2	4
570	R:R:V199	R:R:V203	1.6	No	No	0	3	4
571	R:R:V251	R:R:V255	1.6	No	No	0	3	4
572	S:S:V148	S:S:V152	1.6	No	No	0	3	2
573	S:S:V199	S:S:V203	1.6	No	No	0	3	4
574	S:S:V251	S:S:V255	1.6	No	No	0	3	4
575	S:S:S322	S:S:T321	1.6	No	No	0	5	4
576	R:R:C303	R:R:L41	1.59	No	No	0	7	5
577	R:R:T207	R:R:V203	1.59	No	No	0	3	4
578	R:R:T206	R:R:V211	1.59	No	No	0	5	4
579	R:R:T207	R:R:V211	1.59	No	No	0	3	4
580	R:R:T207	R:R:V212	1.59	No	No	0	3	6
581	R:R:T215	R:R:V211	1.59	No	No	0	2	4
582	S:S:C320	S:S:L48	1.59	No	No	0	6	5
583	S:S:T190	S:S:V191	1.59	No	No	0	1	2
584	S:S:T207	S:S:V203	1.59	No	No	0	3	4
585	S:S:T206	S:S:V211	1.59	No	No	0	5	4
586	S:S:T207	S:S:V212	1.59	No	No	0	3	6
587	S:S:T215	S:S:V211	1.59	No	No	0	2	4
588	S:S:C260	S:S:L304	1.59	No	No	0	7	6
589	S:S:I249	S:S:S248	1.55	Yes	No	0	7	6
590	R:R:K60	R:R:S57	1.53	No	No	0	6	6
591	S:S:L201	S:S:S204	1.5	No	No	0	4	4
592	S:S:L259	S:S:V255	1.49	No	No	0	5	4
593	S:S:L40	S:S:T44	1.47	No	No	0	5	4
594	R:R:F291	R:R:P292	1.44	Yes	No	0	4	4
595	S:S:E18	S:S:S17	1.44	No	No	0	5	5
596	S:S:P134	S:S:R133	1.44	No	No	0	8	6
597	S:S:L159	S:S:M162	1.41	No	No	0	4	4
598	R:R:L37	R:R:L40	1.38	No	No	0	5	5
599	R:R:L156	R:R:L160	1.38	No	No	0	4	4
600	R:R:R143	R:R:V144	1.31	No	No	0	3	4
601	S:S:K234	S:S:R233	1.24	No	No	0	3	4
602	S:S:F118	S:S:L156	1.22	Yes	No	0	5	4
603	R:R:F223	R:R:Q226	1.17	No	No	0	5	3
604	R:R:F222	R:R:F223	1.07	No	No	0	3	5
605	S:S:R241	S:S:R244	1.07	No	No	0	4	5
606	S:S:R241	S:S:R245	1.07	No	No	0	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I31	5.0875	4	1	6
2	R:R:Y35	7.135	4	1	7
3	R:R:F39	7.1025	4	0	6
4	R:R:F54	5.5575	4	0	3
5	R:R:R62	11.335	4	3	7
6	R:R:F67	5.575	4	0	7
7	R:R:D75	5.5125	4	0	9
8	R:R:F78	9.396	5	1	6
9	R:R:W85	6.242	5	1	6
10	R:R:Y88	6.165	4	1	5
11	R:R:W95	6.25556	9	1	8
12	R:R:F97	10.962	5	1	6
13	R:R:C102	5.015	4	1	9
14	R:R:Y107	5.708	5	0	5
15	R:R:F110	7.06	4	8	5
16	R:R:N112	6.2675	4	0	8
17	R:R:Y114	3.874	5	8	6
18	R:R:R127	4.955	4	0	9
19	R:R:W154	6.1175	4	0	9
20	R:R:R168	8.6575	4	1	5
21	R:R:C181	6.195	4	1	9
22	R:R:Y182	6.935	4	9	4
23	R:R:Y185	6.664	5	0	5
24	R:R:L253	6.195	4	3	7
25	R:R:F257	9.3525	4	0	8
26	R:R:W261	10.888	5	5	9
27	R:R:Y264	7.27	4	5	6
28	R:R:H265	8.266	5	5	8
29	R:R:W279	5.96333	6	0	1
30	R:R:F291	4.2575	4	0	4
31	R:R:Y299	9.57	5	1	7
32	R:R:N305	5.2075	4	3	9
33	R:R:Y309	6.875	6	3	9
34	R:R:D313	5.38	4	3	8
35	R:R:R315	9.5575	4	3	7
36	R:R:F316	4.42	7	3	9
37	S:S:Y35	5.084	5	0	7
38	S:S:N46	5.8625	4	0	9
39	S:S:L50	4.0925	4	0	7
40	S:S:T52	4.7375	4	6	7
41	S:S:R55	6.325	4	6	6
42	S:S:R62	13.7725	4	7	7
43	S:S:D75	7.625	4	2	9
44	S:S:F78	9.41	5	2	6
45	S:S:W85	8.2625	4	2	6
46	S:S:W95	6.71556	9	2	8
47	S:S:F97	11.51	5	2	6
48	S:S:Y107	6.72	5	0	5
49	S:S:F110	7.6625	4	12	5
50	S:S:N112	5.6625	4	2	8
51	S:S:Y114	5.61833	6	12	6
52	S:S:F118	3.59	5	0	5
53	S:S:Y128	8.982	5	0	8
54	S:S:L129	4.3025	4	0	5
55	S:S:S145	2.8225	4	0	4
56	S:S:W154	4.745	6	0	9
57	S:S:R168	8.382	5	2	5
58	S:S:D184	5.195	4	0	3
59	S:S:Y185	8.61	4	0	5
60	S:S:F214	7.07	4	0	6
61	S:S:Y221	5.65	4	0	8
62	S:S:F223	3.83	4	0	5
63	S:S:I249	3.9025	4	0	7
64	S:S:F257	8.34	5	4	8
65	S:S:W261	9.57667	6	4	9
66	S:S:Y264	5.355	4	4	6
67	S:S:H265	8.18	4	4	8
68	S:S:W279	5.82167	6	0	1
69	S:S:L287	7.285	4	0	4
70	S:S:Y299	9.468	5	2	7
71	S:S:N301	6.9875	4	4	9
72	S:S:Y309	7.565	4	0	9
73	S:S:D313	5.8175	4	7	8
74	S:S:R315	9.0025	4	7	7
75	S:S:F316	5.396	5	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F78	R:R:Y299	12.2742	18.57	Yes	Yes	1	6	7
2	R:R:D75	R:R:N112	29.0786	5.39	Yes	Yes	0	9	8
3	R:R:F78	R:R:N112	29.9876	12.08	Yes	Yes	0	6	8
4	R:R:D75	R:R:S302	29.0369	5.89	Yes	No	0	9	8
5	R:R:F78	R:R:S302	29.6429	3.96	Yes	No	0	6	8
6	R:R:F316	R:R:Y309	45.514	4.13	Yes	Yes	3	9	9
7	R:R:N305	R:R:Y309	48.0069	5.81	Yes	Yes	3	9	9
8	R:R:D75	R:R:N305	54.1914	4.04	Yes	Yes	0	9	9
9	R:R:D65	R:R:R61	10.0283	7.15	No	No	0	8	6
10	R:R:D313	R:R:R62	27.579	5.96	Yes	Yes	3	8	7
11	R:R:D313	R:R:F316	38.1329	3.58	Yes	Yes	3	8	9
12	R:R:L246	R:R:R62	21.4228	3.64	No	Yes	0	7	7
13	R:R:L246	R:R:R127	20.0223	9.72	No	Yes	0	7	9
14	R:R:F67	R:R:L123	12.2489	7.31	Yes	No	0	7	8
15	R:R:I250	R:R:L123	12.9606	7.14	No	No	0	7	8
16	R:R:I250	R:R:R127	13.6712	3.76	No	Yes	0	7	9
17	R:R:I109	R:R:Y299	29.2864	6.04	No	Yes	1	6	7
18	R:R:I109	R:R:W85	79.0454	5.87	No	Yes	1	6	6
19	R:R:F97	R:R:W95	99.024	15.03	Yes	Yes	1	6	8
20	R:R:C102	R:R:W95	10.0164	5.22	Yes	Yes	1	9	8
21	R:R:F97	S:S:F101	99.5214	6.43	Yes	No	0	6	5
22	R:R:F101	S:S:F101	99.7446	19.29	No	No	0	5	5
23	R:R:F101	S:S:F97	99.943	6.43	No	Yes	0	5	6
24	R:R:C181	R:R:R168	10.3372	8.36	Yes	Yes	1	9	5
25	R:R:S298	R:R:Y299	27.0211	5.09	No	Yes	0	7	7
26	R:R:S298	R:R:W261	26.7052	9.88	No	Yes	0	7	9
27	R:R:F257	R:R:W261	16.5782	20.04	Yes	Yes	0	8	9
28	R:R:F257	R:R:L120	13.1341	6.09	Yes	No	0	8	8
29	R:R:L120	R:R:V254	12.7439	5.96	No	No	0	8	7
30	R:R:V254	R:R:Y221	12.3506	8.83	No	No	0	7	8
31	R:R:V251	R:R:Y221	11.9271	3.79	No	No	0	3	8
32	R:R:L247	R:R:V251	10.6863	2.98	No	No	0	6	3
33	R:R:I224	R:R:L247	10.2708	4.28	No	No	0	8	6
34	R:R:M183	R:R:R168	17.695	4.96	No	Yes	0	5	5
35	S:S:F97	S:S:W95	100	15.03	Yes	Yes	2	6	8
36	S:S:W85	S:S:W95	64.2951	9.37	Yes	Yes	2	6	8
37	S:S:I109	S:S:W85	64.8659	7.05	No	Yes	2	6	6
38	S:S:I109	S:S:Y299	20.8629	7.25	No	Yes	2	6	7
39	S:S:S298	S:S:Y299	20.0997	5.09	No	Yes	0	7	7
40	S:S:S298	S:S:W261	19.9628	12.36	No	Yes	0	7	9
41	S:S:W261	S:S:Y264	10.5524	3.86	Yes	Yes	4	9	6
42	S:S:F78	S:S:I109	43.9207	7.54	Yes	No	2	6	6
43	S:S:F78	S:S:N112	22.9551	9.67	Yes	Yes	2	6	8
44	S:S:D75	S:S:N112	22.4344	4.04	Yes	Yes	2	9	8
45	S:S:F78	S:S:S302	22.4007	3.96	Yes	No	2	6	8
46	S:S:D75	S:S:S302	22.2271	10.31	Yes	No	2	9	8
47	S:S:D75	S:S:N305	37.2998	6.73	Yes	No	0	9	9
48	S:S:L253	S:S:N305	41.759	4.12	No	No	0	7	9
49	S:S:L253	S:S:Y309	41.2467	9.38	No	Yes	0	7	9
50	S:S:I249	S:S:Y309	33.4436	4.84	Yes	Yes	0	7	9
51	S:S:D313	S:S:I249	27.5502	4.2	Yes	Yes	0	8	7
52	S:S:D313	S:S:R62	20.9353	5.96	Yes	Yes	7	8	7
53	S:S:L246	S:S:R62	18.8192	8.5	No	Yes	0	7	7
54	S:S:L246	S:S:R127	17.7094	10.93	No	No	0	7	9
55	S:S:D126	S:S:R127	16.5956	3.57	No	No	0	8	9
56	S:S:C102	S:S:W95	16.7072	5.22	No	Yes	2	9	8
57	S:S:C102	S:S:R168	16.4612	6.96	No	Yes	2	9	5
58	S:S:R168	S:S:S106	12.0228	14.5	Yes	No	0	5	5
59	S:S:S106	S:S:V164	11.6539	4.85	No	No	0	5	4
60	S:S:F110	S:S:V164	24.4364	14.42	Yes	No	0	5	4
61	S:S:F110	S:S:Y114	19.7967	7.22	Yes	Yes	12	5	6
62	S:S:F118	S:S:Y114	16.2842	5.16	Yes	Yes	0	5	6
63	S:S:F118	S:S:L153	14.8644	4.87	Yes	No	0	5	6
64	S:S:L153	S:S:W154	13.9048	4.56	No	Yes	0	6	9
65	S:S:C181	S:S:W95	16.7072	5.22	No	Yes	2	9	8
66	S:S:C181	S:S:R168	16.4612	5.57	No	Yes	2	9	5
67	S:S:M183	S:S:R168	20.5832	11.17	No	Yes	0	5	5
68	S:S:M183	S:S:V164	13.573	4.56	No	No	0	5	4
69	S:S:D126	S:S:L129	15.4778	4.07	No	Yes	0	8	5
70	S:S:F125	S:S:L129	11.5343	4.87	No	Yes	0	6	5
71	S:S:C220	S:S:F125	10.967	5.59	No	No	0	6	6
72	S:S:C220	S:S:Y128	10.3987	8.06	No	Yes	0	6	8
73	S:S:M183	S:S:Y185	10.5058	8.38	No	Yes	0	5	5
74	R:R:W85	R:R:W95	74.6417	8.43	Yes	Yes	1	6	8
75	R:R:F78	R:R:I109	49.64	6.28	Yes	No	1	6	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8XQI

PDB Summary
PDB	8XQI
Class	A
SubFamily	Peptide
Type	Apelin
SubType	Apelin
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.25
Date	2025-01-22
D.O.I.	doi.org/10.1038/s41467-024-55555-6

Net Summary
I_min	3.57
Number of Linked Nodes	559
Number of Links	606
Number of Hubs	75
Number of Links mediated by Hubs	289
Number of Communities	12
Number of Nodes involved in Communities	72
Number of Links involved in Communities	94

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	314991
Length Of Smallest Path	3
Average Path Length	21.4899
Length of Longest Path	55
Minimum Path Strength	1.07
Average Path Strength	7.47817
Maximum Path Strength	16.2
Minimum Path Correlation	0.71
Average Path Correlation	0.970279
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	54.4721
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.2903
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • apelin receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • developmental process • heart development • multicellular organism development • multicellular organismal process • anatomical structure development • animal organ development • circulatory system development • system development • atrioventricular valve development • heart valve development • cardiac chamber morphogenesis • heart morphogenesis • ventricular septum development • anatomical structure morphogenesis • cardiac septum development • cardiac septum morphogenesis • ventricular septum morphogenesis • cardiac chamber development • animal organ morphogenesis • cardiac ventricle development • regulation of body fluid levels • regulation of biological quality • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • tube morphogenesis • anatomical structure formation involved in morphogenesis • blood vessel development • regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis • positive regulation of cell population proliferation • endothelial cell proliferation • positive regulation of biological process • positive regulation of endothelial cell proliferation • epithelial cell proliferation • positive regulation of cellular process • positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis • cell population proliferation • blood vessel endothelial cell proliferation involved in sprouting angiogenesis • positive regulation of epithelial cell proliferation • sprouting angiogenesis • regulation of endothelial cell proliferation • regulation of cell population proliferation • regulation of epithelial cell proliferation • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • regulation of metabolic process • embryonic morphogenesis • embryo development • gastrulation • mesenchyme morphogenesis • endocardial cushion morphogenesis • mesenchyme development • tissue development • endocardial cushion formation • tissue morphogenesis • endocardial cushion development • artery development • aorta development • regulation of localization • negative adaptation of signaling pathway • regulation of G protein-coupled receptor internalization • receptor internalization • negative regulation of biological process • regulation of signal transduction • regulation of receptor internalization • vesicle-mediated transport • negative regulation of G protein-coupled receptor signaling pathway • localization • positive regulation of endocytosis • regulation of G protein-coupled receptor signaling pathway • positive regulation of receptor-mediated endocytosis • positive regulation of G protein-coupled receptor internalization • establishment of localization • positive regulation of receptor internalization • regulation of response to stimulus • adaptation of signaling pathway • receptor-mediated endocytosis • import into cell • regulation of cellular component organization • positive regulation of cellular component organization • transport • negative regulation of signaling • desensitization of G protein-coupled receptor signaling pathway • negative regulation of cell communication • cellular component organization • negative regulation of cellular process • cellular component organization or biogenesis • regulation of endocytosis • G protein-coupled receptor internalization • regulation of signaling • regulation of transport • negative regulation of response to stimulus • regulation of receptor-mediated endocytosis • regulation of vesicle-mediated transport • negative regulation of signal transduction • positive regulation of transport • regulation of cell communication • endocytosis • cellular developmental process • vasculogenesis • cell differentiation • regulation of developmental process • regulation of vasculature development • positive regulation of developmental process • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • positive regulation of angiogenesis • positive regulation of vasculature development • regulation of angiogenesis • positive regulation of multicellular organismal process • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • venous blood vessel development • regulation of calcium ion transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • intracellular calcium ion homeostasis • calcium ion transport • positive regulation of monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation homeostasis • monoatomic cation transport • intracellular monoatomic ion homeostasis • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • inorganic ion transmembrane transport • inorganic cation transmembrane transport • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • chemical homeostasis • cellular localization • inorganic ion homeostasis • homeostatic process • monoatomic ion transmembrane transport • calcium ion homeostasis • regulation of monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • metal ion transport • maintenance of location in cell • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • monoatomic ion transport • intracellular chemical homeostasis • positive regulation of release of sequestered calcium ion into cytosol • regulation of metal ion transport • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • sequestering of calcium ion • cellular homeostasis • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • negative regulation of intracellular signal transduction • intracellular signal transduction • cAMP-mediated signaling • regulation of intracellular signal transduction • intracellular signaling cassette • negative regulation of cAMP-mediated signaling • regulation of cAMP-mediated signaling • adult heart development • negative regulation of metabolic process • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of macromolecule metabolic process • smooth muscle cell differentiation • muscle cell differentiation • muscle structure development • vascular associated smooth muscle cell differentiation • coronary vasculature development • gap junction assembly • regulation of gap junction assembly • regulation of cellular component biogenesis • cellular component biogenesis • regulation of cell junction assembly • cell junction organization • cellular component assembly • cell junction assembly • cell-cell junction assembly • cell-cell junction organization • pattern specification process • embryonic heart tube development • embryonic heart tube morphogenesis • heart looping • determination of bilateral symmetry • epithelial tube morphogenesis • embryonic organ development • determination of left/right symmetry • specification of symmetry • embryonic organ morphogenesis • epithelium development • morphogenesis of an epithelium • determination of heart left/right asymmetry • regionalization • left/right pattern formation • cell periphery • cellular anatomical structure • plasma membrane • membrane
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35414
Sequence	>8XQI_Chain_R W K S S G A L I P A I Y M L V F L L G T T G N G L V L W T V F R S S R E K R R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D Y D W P F G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R P V A N A R L R L R V S G A V A T A V L W V L A A L L A M P V M V L R T T G D L E N T T K V Q C Y M D Y S M V A T V S S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L L H W P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R F R Q A C T S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8Z74	A	Peptide	Apelin	Apelin	Homo sapiens	Agonistic antibody	-	-	3.01	2025-01-22	10.1038/s41467-024-55555-6
	8XQJ	A	Peptide	Apelin	Apelin	Homo sapiens	JN241	-	-	2.95	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQI	A	Peptide	Apelin	Apelin	Homo sapiens	-	-	-	3.25	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8Z7J	A	Peptide	Apelin	Apelin	Homo sapiens	Agonistic antibody	-	Gi1/β1/γ2	3.12	2025-01-22	10.1038/s41467-024-55555-6
	8XQF	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-	Gi1/β1/γ2	3.13	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQE	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-	Gi1/β1/γ2	3.48	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8S4D	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-	-	2.58	2024-12-04	doi.org/10.1038/s41467-024-55381-w
	8XZJ	A	Peptide	Apelin	Apelin	Homo sapiens	WN353	-	Gi1/β1/γ2	3	2024-03-20	10.1016/j.cell.2024.02.004
	8XZI	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-	Gi1/β1/γ2	2.7	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZH	A	Peptide	Apelin	Apelin	Homo sapiens	MM07	-	Gi1/β1/γ2	2.06	2024-03-20	10.1016/j.cell.2024.02.004
	8XZG	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-	Gi1/β1/γ2	3.2	2024-03-20	10.1016/j.cell.2024.02.004
	8XZF	A	Peptide	Apelin	Apelin	Homo sapiens	WN561	-	Gi1/β1/γ2	3	2024-03-20	10.1016/j.cell.2024.02.004
	7SUS	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-	-	2.7	2022-07-27	10.1038/s41594-022-00797-5
	7W0P	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-	Gi1/β1/γ2	3.16	2022-07-27	10.1038/s41594-022-00797-5
	7W0O	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-	Gi1/β1/γ2	3.78	2022-07-27	10.1038/s41594-022-00797-5
	7W0N	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-	Gi1/β1/γ2	4.21	2022-07-27	10.1038/s41594-022-00797-5
	7W0M	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-	Gi1/β1/γ2	3.71	2022-07-27	10.1038/s41594-022-00797-5
	7W0L	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-	Gi1/β1/γ2	3.57	2022-07-27	10.1038/s41594-022-00797-5
	6KNM	A	Peptide	Apelin	Apelin	Homo sapiens	JN241-9	-	-	3.2	2020-01-29	10.1126/sciadv.aax7379
	5VBL	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin mimetic peptide agonist	-	-	2.6	2017-05-31	10.1016/j.str.2017.04.008

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