Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:Y35 9.1225407
2R:R:F39 6.0675436
3R:R:V49 3.985408
4R:R:W51 5.24443
5R:R:T52 6.36407
6R:R:R61 6.2375406
7R:R:R62 7.128507
8R:R:F67 4.21167657
9R:R:L71 4.906529
10R:R:D75 7.606529
11R:R:F78 7.765616
12R:R:W85 6.75616
13R:R:W95 10.595618
14R:R:F97 10.852506
15R:R:Y107 5.8325405
16R:R:I109 6.2275416
17R:R:Y114 5.3625406
18R:R:Y128 6.075408
19R:R:L129 6.038505
20R:R:R141 6.586567
21R:R:W154 4.854509
22R:R:L167 4.335405
23R:R:T176 5.4925493
24R:R:C181 7.0875419
25R:R:D184 6.095483
26R:R:F210 7.33418
27R:R:F214 7.945416
28R:R:Y221 6.495608
29R:R:F223 4.97475
30R:R:L253 8.445427
31R:R:F257 6.564518
32R:R:W261 6.8325819
33R:R:Y264 8.30714716
34R:R:H265 9.345418
35R:R:W279 7.408501
36R:R:F291 8.602514
37R:R:Y299 9.128517
38R:R:N305 5.798529
39R:R:Y309 6.58857729
40R:R:F311 4.838506
41R:R:F316 6.686509
42L:L:?1 10.2151210
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:I31 R:R:Y35 11.12078.46NoYes067
2R:R:T295 R:R:Y35 10.73056.24NoYes057
3L:L:?1 R:R:T295 10.50727.71YesNo105
4L:L:?1 R:R:W85 43.82088.94YesYes106
5R:R:L76 R:R:N46 10.60144.12NoNo079
6R:R:D75 R:R:N46 1006.73YesNo099
7R:R:D75 R:R:S302 61.143511.78YesNo098
8R:R:F78 R:R:S302 61.38036.61YesNo068
9L:L:?1 R:R:F78 30.41037.17YesYes106
10R:R:N46 R:R:P306 90.83016.52NoNo099
11R:R:P306 R:R:V49 87.30263.53NoYes098
12R:R:A310 R:R:V49 32.28315.09NoYes068
13R:R:F311 R:R:V49 48.53493.93YesYes068
14R:R:A310 R:R:F316 30.98884.16NoYes069
15R:R:F316 R:R:T52 21.90511.67YesYes097
16R:R:F311 R:R:F316 31.18537.5YesYes069
17R:R:C320 R:R:F311 13.6934.19NoYes066
18R:R:C320 R:R:T52 11.11538.45NoYes067
19R:R:T52 R:R:W51 24.54193.64YesYes073
20R:R:R55 R:R:W51 12.28317NoYes463
21R:R:F316 R:R:V53 19.29232.62YesNo096
22R:R:R61 R:R:V53 16.46442.62YesNo066
23R:R:R58 R:R:R61 11.22291.07NoYes066
24R:R:F316 R:R:R62 19.21167.48YesYes097
25R:R:F67 R:R:L123 10.54497.31YesNo078
26R:R:L123 R:R:Y309 11.76114.69NoYes089
27R:R:N305 R:R:Y309 29.89915.81YesYes299
28R:R:N301 R:R:N305 26.44694.09NoYes099
29R:R:N301 R:R:W261 26.86676.78NoYes099
30L:L:?1 R:R:W261 34.08055.21YesYes109
31R:R:D75 R:R:L71 38.14885.43YesYes299
32R:R:C119 R:R:L71 31.54853.17NoYes079
33R:R:C119 R:R:L153 30.17094.76NoNo076
34R:R:L153 R:R:W154 24.60656.83NoYes069
35R:R:N112 R:R:W154 18.9563.39NoYes089
36R:R:F97 R:R:W95 16.45915.03YesYes068
37R:R:W85 R:R:W95 21.200110.31YesYes168
38R:R:F97 R:R:P96 10.700917.34YesNo064
39R:R:C181 R:R:W85 31.72615.22YesYes196
40R:R:C181 R:R:R168 28.6212.79YesNo095
41R:R:N112 R:R:V111 13.21942.96NoNo084
42R:R:V111 R:R:Y107 10.31888.83NoYes045
43R:R:F257 R:R:W261 33.97826.01YesYes189
44R:R:F257 R:R:M217 20.93918.71YesNo088
45R:R:M217 R:R:S124 20.72656.13NoNo089
46R:R:C220 R:R:S124 36.02853.44NoNo069
47R:R:S124 R:R:Y221 35.29410.17NoYes098
48R:R:L129 R:R:Y128 22.29523.52YesYes058
49R:R:C220 R:R:Y128 34.50834.03NoYes068
50R:R:I224 R:R:Y221 22.41633.63NoYes088
51R:R:L167 R:R:M183 20.55975.65YesNo055
52R:R:M183 R:R:R168 26.34478.69NoNo055
53R:R:L253 R:R:Y309 26.53316.41YesYes279
54R:R:I224 R:R:I228 19.31392.94NoNo088
55R:R:F232 R:R:L246 13.16834.87NoNo047
56R:R:I228 R:R:L246 14.62948.56NoNo087
57R:R:F291 R:R:V267 14.93885.24YesNo044
58L:L:?1 R:R:F291 11.580823.09YesYes104
59R:R:L287 R:R:V267 10.4054.47NoNo044
60R:R:R127 R:R:Y309 22.59115.14NoYes099
61R:R:F78 R:R:I109 17.22866.28YesYes166
62R:R:I109 R:R:W85 17.77753.52YesYes166
63R:R:L71 R:R:Y309 27.94563.52YesYes299
64R:R:D75 R:R:N305 29.41756.73YesYes299
65R:R:R127 R:R:Y221 21.84588.23NoYes098
66R:R:L253 R:R:Y221 22.71764.69YesYes078
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M288 R:R:Y21 9.58 1 No No 4 4 1 2
R:R:L82 R:R:Y35 16.41 0 No Yes 7 7 2 2
R:R:T295 R:R:Y35 6.24 1 No Yes 5 7 1 2
R:R:V38 R:R:Y299 5.05 0 No Yes 7 7 2 1
R:R:F78 R:R:I109 6.28 1 Yes Yes 6 6 1 1
R:R:F78 R:R:M113 4.98 1 Yes No 6 7 1 2
R:R:F78 R:R:W261 4.01 1 Yes Yes 6 9 1 1
R:R:F78 R:R:Y299 17.54 1 Yes Yes 6 7 1 1
R:R:F78 R:R:S302 6.61 1 Yes No 6 8 1 2
L:L:?1 R:R:F78 7.17 1 Yes Yes 0 6 0 1
R:R:L82 R:R:Y299 10.55 0 No Yes 7 7 2 1
R:R:W85 R:R:Y88 3.86 1 Yes No 6 5 1 2
R:R:W85 R:R:W95 10.31 1 Yes Yes 6 8 1 2
R:R:S105 R:R:W85 8.65 0 No Yes 5 6 2 1
R:R:I109 R:R:W85 3.52 1 Yes Yes 6 6 1 1
R:R:C181 R:R:W85 5.22 1 Yes Yes 9 6 2 1
L:L:?1 R:R:W85 8.94 1 Yes Yes 0 6 0 1
R:R:W95 R:R:Y88 10.61 1 Yes No 8 5 2 2
R:R:C181 R:R:W95 13.06 1 Yes Yes 9 8 2 2
R:R:I109 R:R:Y299 4.84 1 Yes Yes 6 7 1 1
L:L:?1 R:R:I109 10.27 1 Yes Yes 0 6 0 1
R:R:F110 R:R:Y114 5.16 0 No Yes 5 6 1 2
R:R:F110 R:R:V164 11.8 0 No No 5 4 1 2
L:L:?1 R:R:F110 7.96 1 Yes No 0 5 0 1
R:R:M113 R:R:W261 9.31 1 No Yes 7 9 2 1
R:R:M113 R:R:Y264 7.18 1 No Yes 7 6 2 1
R:R:F257 R:R:W261 6.01 1 Yes Yes 8 9 2 1
R:R:W261 R:R:Y264 6.75 1 Yes Yes 9 6 1 1
R:R:H265 R:R:W261 4.23 1 Yes Yes 8 9 2 1
R:R:S298 R:R:W261 12.36 1 No Yes 7 9 1 1
R:R:N301 R:R:W261 6.78 0 No Yes 9 9 2 1
L:L:?1 R:R:W261 5.21 1 Yes Yes 0 9 0 1
R:R:H265 R:R:Y264 10.89 1 Yes Yes 8 6 2 1
R:R:F291 R:R:Y264 5.16 1 Yes Yes 4 6 1 1
R:R:S298 R:R:Y264 5.09 1 No Yes 7 6 1 1
L:L:?1 R:R:Y264 20.69 1 Yes Yes 0 6 0 1
R:R:F291 R:R:V267 5.24 1 Yes No 4 4 1 2
R:R:D284 R:R:Y271 3.45 0 No No 4 4 2 1
R:R:M288 R:R:Y271 3.59 1 No No 4 4 1 1
L:L:?1 R:R:Y271 15.33 1 Yes No 0 4 0 1
L:L:?1 R:R:M288 4.62 1 Yes No 0 4 0 1
R:R:F291 R:R:P292 4.33 1 Yes No 4 4 1 2
R:R:F291 R:R:T295 5.19 1 Yes No 4 5 1 1
L:L:?1 R:R:F291 23.09 1 Yes Yes 0 4 0 1
L:L:?1 R:R:T295 7.71 1 Yes No 0 5 0 1
L:L:?1 R:R:S298 3.93 1 Yes No 0 7 0 1
L:L:?1 R:R:Y299 7.66 1 Yes Yes 0 7 0 1
R:R:K268 R:R:Y264 2.39 0 No Yes 5 6 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8XZI_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.44
Number of Linked Nodes 289
Number of Links 325
Number of Hubs 42
Number of Links mediated by Hubs 170
Number of Communities 9
Number of Nodes involved in Communities 49
Number of Links involved in Communities 71
Path Summary
Number Of Nodes in MetaPath 67
Number Of Links MetaPath 66
Number of Shortest Paths 77530
Length Of Smallest Path 3
Average Path Length 13.0468
Length of Longest Path 26
Minimum Path Strength 1.59
Average Path Strength 6.38002
Maximum Path Strength 16.185
Minimum Path Correlation 0.7
Average Path Correlation 0.924998
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.54545
Average % Of Corr. Nodes 50.7355
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 47.6887
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases   • G protein-coupled receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeA1D
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeA1D
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP35414
Sequence
>8XZI_nogp_Chain_R
CEYTDWKSS GALIPAIYM LVFLLGTTG NGLVLWTVF RSSREKRRS 
ADIFIASLA VADLTFVVT LPLWATYTY RDYDWPFGT FFCKLSSYL 
IFVNMYASV FCLTGLSFD RYLAIVRPV ANARLRLRV SGAVATAVL 
WVLAALLAM PVMVLRTTG DLENTTKVQ CYMDYSMVA TVSSEWAWE 
VGLGVSSTT VGFVVPFTI MLTCYFFIA QTIAGHFRK ERIEGLRKR 
RRLLSIIVV LVVTFALCW MPYHLVKTL YMLGSLLHW PCDFDLFLM 
NIFPYCTCI SYVNSCLNP FLYAFFDPR FRQACTSML CCG


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XZFAPeptideApelinApelinHomo sapiensWN561-Gi1/β1/γ232024-03-20doi.org/10.1016/j.cell.2024.02.004
8XZF (No Gprot) APeptideApelinApelinHomo sapiensWN561-32024-03-20doi.org/10.1016/j.cell.2024.02.004
8XZGAPeptideApelinApelinHomo sapiensApelin-13-Gi1/β1/γ23.22024-03-20doi.org/10.1016/j.cell.2024.02.004
8XZG (No Gprot) APeptideApelinApelinHomo sapiensApelin-13-3.22024-03-20doi.org/10.1016/j.cell.2024.02.004
8XZHAPeptideApelinApelinHomo sapiensMM07-Gi1/β1/γ22.062024-03-20doi.org/10.1016/j.cell.2024.02.004
8XZH (No Gprot) APeptideApelinApelinHomo sapiensMM07-2.062024-03-20doi.org/10.1016/j.cell.2024.02.004
8XZJAPeptideApelinApelinHomo sapiensWN353-Gi1/β1/γ232024-03-20doi.org/10.1016/j.cell.2024.02.004
8XZJ (No Gprot) APeptideApelinApelinHomo sapiensWN353-32024-03-20doi.org/10.1016/j.cell.2024.02.004
5VBLAPeptideApelinApelinHomo sapiensApelin mimetic peptide agonist--2.62017-05-31doi.org/10.1016/j.str.2017.04.008
8Z74APeptideApelinApelinHomo sapiensAgonistic antibody--3.012025-01-22doi.org/10.1038/s41467-024-55555-6
8Z7JAPeptideApelinApelinHomo sapiensAgonistic antibody-Gi1/β1/γ23.122025-01-22doi.org/10.1038/s41467-024-55555-6
8Z7J (No Gprot) APeptideApelinApelinHomo sapiensAgonistic antibody-3.122025-01-22doi.org/10.1038/s41467-024-55555-6
7SUSAPeptideApelinApelinHomo sapiensPubChem 122701908--2.72022-07-27doi.org/10.1038/s41594-022-00797-5
7W0LAPeptideApelinApelinHomo sapiensPubChem 122701908-Gi1/β1/γ23.572022-07-27doi.org/10.1038/s41594-022-00797-5
7W0L (No Gprot) APeptideApelinApelinHomo sapiensPubChem 122701908-3.572022-07-27doi.org/10.1038/s41594-022-00797-5
7W0MAPeptideApelinApelinHomo sapiensPubChem 122701908-Gi1/β1/γ23.712022-07-27doi.org/10.1038/s41594-022-00797-5
7W0M (No Gprot) APeptideApelinApelinHomo sapiensPubChem 122701908-3.712022-07-27doi.org/10.1038/s41594-022-00797-5
7W0NAPeptideApelinApelinHomo sapiensElabela-Gi1/β1/γ24.212022-07-27doi.org/10.1038/s41594-022-00797-5
7W0N (No Gprot) APeptideApelinApelinHomo sapiensElabela-4.212022-07-27doi.org/10.1038/s41594-022-00797-5
7W0OAPeptideApelinApelinHomo sapiensElabela-Gi1/β1/γ23.782022-07-27doi.org/10.1038/s41594-022-00797-5
7W0O (No Gprot) APeptideApelinApelinHomo sapiensElabela-3.782022-07-27doi.org/10.1038/s41594-022-00797-5
7W0PAPeptideApelinApelinHomo sapiensElabela-Gi1/β1/γ23.162022-07-27doi.org/10.1038/s41594-022-00797-5
7W0P (No Gprot) APeptideApelinApelinHomo sapiensElabela-3.162022-07-27doi.org/10.1038/s41594-022-00797-5
6KNMAPeptideApelinApelinHomo sapiensJN241-9--3.22020-01-29doi.org/10.1126/sciadv.aax7379
8XZIAPeptideApelinApelinHomo sapiensCMF-019-Gi1/β1/γ22.72024-03-20doi.org/10.1016/j.cell.2024.02.004
8XZI (No Gprot) APeptideApelinApelinHomo sapiensCMF-019-2.72024-03-20doi.org/10.1016/j.cell.2024.02.004
8S4DAPeptideApelinApelinHomo sapiensCMF-019--2.582024-12-04doi.org/10.1038/s41467-024-55381-w
8XQEAPeptideApelinApelinHomo sapiensApelin-13-Gi1/β1/γ23.482025-01-22doi.org/10.1038/s41467-024-55555-6
8XQE (No Gprot) APeptideApelinApelinHomo sapiensApelin-13-3.482025-01-22doi.org/10.1038/s41467-024-55555-6
8XQFAPeptideApelinApelinHomo sapiensApelin-13-Gi1/β1/γ23.132025-01-22doi.org/10.1038/s41467-024-55555-6
8XQF (No Gprot) APeptideApelinApelinHomo sapiensApelin-13-3.132025-01-22doi.org/10.1038/s41467-024-55555-6
8XQIAPeptideApelinApelinHomo sapiens---3.252025-01-22doi.org/10.1038/s41467-024-55555-6
8XQJAPeptideApelinApelinHomo sapiensJN241--2.952025-01-22doi.org/10.1038/s41467-024-55555-6
9JH3APeptideApelinApelinHomo sapiensCMF-019-Gi1/β1/γ22.932025-04-23doi.org/10.1073/pnas.2423432122
9JH3 (No Gprot) APeptideApelinApelinHomo sapiensCMF-019-2.932025-04-23doi.org/10.1073/pnas.2423432122




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8XZI_nogp.zip



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