psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N289	R:R:S26	5.96	No	No	0	2	3
2	R:R:I31	R:R:P32	5.08	Yes	No	1	6	5
3	R:R:I31	R:R:I34	5.89	Yes	No	1	6	5
4	R:R:I31	R:R:Y35	14.51	Yes	Yes	1	6	7
5	R:R:I31	R:R:T89	4.56	Yes	No	1	6	5
6	R:R:P32	R:R:T89	6.99	No	No	1	5	5
7	R:R:I34	R:R:Y35	4.84	No	Yes	1	5	7
8	R:R:C296	R:R:I34	4.91	No	No	0	5	5
9	R:R:L82	R:R:Y35	11.72	Yes	Yes	1	7	7
10	R:R:A86	R:R:Y35	4	No	Yes	0	6	7
11	R:R:T295	R:R:Y35	8.74	Yes	Yes	1	5	7
12	R:R:Y299	R:R:Y35	7.94	Yes	Yes	1	7	7
13	R:R:M36	R:R:P83	3.35	No	No	0	3	9
14	R:R:V38	R:R:Y299	3.79	No	Yes	0	7	7
15	R:R:C303	R:R:V38	1.71	No	No	0	7	7
16	R:R:F39	R:R:T43	11.67	No	No	0	6	5
17	R:R:F39	R:R:V79	3.93	No	No	1	6	6
18	R:R:F39	R:R:L82	6.09	No	Yes	1	6	7
19	R:R:L40	R:R:T44	2.95	No	No	0	5	4
20	R:R:G42	R:R:L41	1.71	No	No	0	8	5
21	R:R:C303	R:R:G42	3.92	No	No	0	7	8
22	R:R:G45	R:R:T44	3.64	No	No	0	8	4
23	R:R:G45	R:R:P306	4.06	No	No	0	8	9
24	R:R:N46	R:R:V49	2.96	Yes	Yes	4	9	8
25	R:R:A72	R:R:N46	4.69	No	Yes	4	8	9
26	R:R:D75	R:R:N46	14.81	No	Yes	0	9	9
27	R:R:L76	R:R:N46	8.24	No	Yes	0	7	9
28	R:R:G47	R:R:L50	5.13	No	No	0	3	7
29	R:R:T52	R:R:V49	3.17	No	Yes	0	7	8
30	R:R:A72	R:R:V49	1.7	No	Yes	4	8	8
31	R:R:P306	R:R:V49	3.53	No	Yes	0	9	8
32	R:R:F54	R:R:L50	6.09	No	No	0	3	7
33	R:R:R55	R:R:W51	3	No	No	0	6	3
34	R:R:F54	R:R:V53	3.93	No	No	0	3	6
35	R:R:F54	R:R:R58	4.28	No	No	0	3	6
36	R:R:R61	R:R:S56	7.91	No	No	0	6	5
37	R:R:K60	R:R:S57	9.18	No	No	0	6	6
38	R:R:K60	R:R:R61	2.48	No	No	0	6	6
39	R:R:D65	R:R:R61	9.53	No	No	0	8	6
40	R:R:A64	R:R:R62	2.77	No	No	0	8	7
41	R:R:R315	R:R:R62	6.4	No	No	0	7	7
42	R:R:D126	R:R:S63	4.42	No	No	6	8	6
43	R:R:S145	R:R:S63	3.26	Yes	No	6	4	6
44	R:R:D65	R:R:I68	2.8	No	No	0	8	8
45	R:R:F67	R:R:I66	6.28	Yes	No	0	7	5
46	R:R:I66	R:R:T150	9.12	No	No	0	5	6
47	R:R:F67	R:R:L123	3.65	Yes	No	0	7	8
48	R:R:D126	R:R:F67	4.78	No	Yes	0	8	7
49	R:R:A149	R:R:F67	2.77	No	Yes	0	5	7
50	R:R:I68	R:R:Y309	14.51	No	Yes	0	8	9
51	R:R:C119	R:R:S70	5.16	No	No	0	7	9
52	R:R:C119	R:R:L71	4.76	No	No	0	7	9
53	R:R:L71	R:R:N305	6.87	No	No	0	9	9
54	R:R:V73	R:R:W154	2.45	No	No	0	5	9
55	R:R:A115	R:R:A74	1.79	No	No	0	7	8
56	R:R:A74	R:R:S116	1.71	No	No	0	8	9
57	R:R:D75	R:R:S302	8.83	No	No	0	9	8
58	R:R:L76	R:R:V80	2.98	No	No	0	7	4
59	R:R:N112	R:R:T77	11.7	Yes	No	0	8	7
60	R:R:F78	R:R:N112	7.25	Yes	Yes	0	6	8
61	R:R:F78	R:R:M113	4.98	Yes	No	0	6	7
62	R:R:F78	R:R:Y299	6.19	Yes	Yes	0	6	7
63	L:L:?1	R:R:F78	2.63	Yes	Yes	0	0	6
64	R:R:L82	R:R:V79	2.98	Yes	No	1	7	6
65	R:R:T81	R:R:W85	2.43	Yes	Yes	1	7	6
66	R:R:S105	R:R:T81	4.8	No	Yes	1	5	7
67	R:R:L108	R:R:T81	7.37	Yes	Yes	0	4	7
68	R:R:L82	R:R:P83	3.28	Yes	No	0	7	9
69	R:R:L82	R:R:Y299	3.52	Yes	Yes	1	7	7
70	R:R:L84	R:R:W95	5.69	No	Yes	2	6	8
71	R:R:F97	R:R:L84	7.31	Yes	No	2	6	6
72	R:R:F101	R:R:L84	2.44	No	No	2	5	6
73	R:R:S105	R:R:W85	9.88	No	Yes	1	5	6
74	R:R:R168	R:R:W85	3	No	Yes	0	5	6
75	L:L:?1	R:R:W85	13.94	Yes	Yes	1	0	6
76	R:R:R91	R:R:T87	6.47	Yes	No	0	3	4
77	R:R:R91	R:R:Y88	2.06	Yes	No	0	3	5
78	R:R:Y88	R:R:Y93	11.91	No	No	0	5	4
79	R:R:Q180	R:R:Y88	4.51	No	No	0	2	5
80	R:R:D94	R:R:R91	3.57	No	Yes	0	4	3
81	R:R:P96	R:R:R91	11.53	No	Yes	0	4	3
82	R:R:D92	R:R:Y93	2.3	No	No	0	6	4
83	R:R:D94	R:R:K178	15.21	No	No	0	4	2
84	R:R:P96	R:R:W95	5.4	No	Yes	2	4	8
85	R:R:F97	R:R:W95	8.02	Yes	Yes	2	6	8
86	R:R:G98	R:R:W95	2.81	No	Yes	0	8	8
87	R:R:F101	R:R:W95	6.01	No	Yes	2	5	8
88	R:R:C102	R:R:W95	11.75	No	Yes	2	9	8
89	R:R:C181	R:R:W95	5.22	No	Yes	2	9	8
90	R:R:F97	R:R:P96	5.78	Yes	No	2	6	4
91	R:R:F101	R:R:F97	10.72	No	Yes	2	5	6
92	R:R:G98	R:R:T99	1.82	No	No	0	8	3
93	R:R:K103	R:R:T99	3	Yes	No	0	7	3
94	R:R:F100	R:R:K103	2.48	No	Yes	0	1	7
95	R:R:C102	R:R:C181	7.28	No	No	2	9	9
96	R:R:K103	R:R:V166	15.18	Yes	No	0	7	4
97	R:R:K103	R:R:R168	2.48	Yes	No	0	7	5
98	R:R:R168	R:R:S106	13.18	No	No	0	5	5
99	R:R:V111	R:R:Y107	2.52	Yes	Yes	7	4	5
100	R:R:A161	R:R:Y107	2.67	No	Yes	7	7	5
101	R:R:M162	R:R:Y107	4.79	No	Yes	0	4	5
102	R:R:M165	R:R:Y107	8.38	No	Yes	0	5	5
103	R:R:I109	R:R:L108	4.28	No	Yes	0	6	4
104	R:R:L108	R:R:N112	2.75	Yes	Yes	0	4	8
105	R:R:F110	R:R:I109	5.02	Yes	No	1	5	6
106	L:L:?1	R:R:I109	9.25	Yes	No	1	0	6
107	R:R:F110	R:R:Y114	3.09	Yes	Yes	0	5	6
108	R:R:F110	R:R:V164	10.49	Yes	No	0	5	4
109	L:L:?1	R:R:F110	11.4	Yes	Yes	1	0	5
110	R:R:N112	R:R:V111	2.96	Yes	Yes	0	8	4
111	R:R:A157	R:R:V111	1.7	No	Yes	0	7	4
112	R:R:A161	R:R:V111	3.39	No	Yes	7	7	4
113	R:R:M113	R:R:Y114	5.99	No	Yes	0	7	6
114	R:R:M113	R:R:W261	3.49	No	Yes	0	7	9
115	R:R:F118	R:R:Y114	2.06	No	Yes	0	5	6
116	R:R:L160	R:R:Y114	10.55	No	Yes	0	4	6
117	R:R:S205	R:R:Y114	2.54	Yes	Yes	0	4	6
118	R:R:A115	R:R:W154	2.59	No	No	0	7	9
119	R:R:A115	R:R:A157	1.79	No	No	0	7	7
120	R:R:S116	R:R:V117	3.23	No	No	0	9	7
121	R:R:P213	R:R:V117	3.53	Yes	No	0	9	7
122	R:R:F118	R:R:L153	3.65	No	No	0	5	6
123	R:R:F257	R:R:L120	2.44	No	No	0	8	8
124	R:R:G122	R:R:T121	1.82	No	Yes	0	6	7
125	R:R:P213	R:R:T121	3.5	Yes	Yes	0	9	7
126	R:R:I216	R:R:T121	3.04	No	Yes	0	6	7
127	R:R:M217	R:R:T121	4.52	No	Yes	0	8	7
128	R:R:L123	R:R:R127	6.07	No	No	0	8	9
129	R:R:L123	R:R:Y309	3.52	No	Yes	0	8	9
130	R:R:M217	R:R:S124	6.13	No	No	0	8	9
131	R:R:C220	R:R:S124	5.16	No	No	9	6	9
132	R:R:S124	R:R:Y221	10.17	No	Yes	9	9	8
133	R:R:F125	R:R:L129	9.74	No	No	0	6	5
134	R:R:F125	R:R:V144	5.24	No	No	0	6	4
135	R:R:D126	R:R:S145	2.94	No	Yes	6	8	4
136	R:R:I131	R:R:R127	3.76	No	No	0	8	9
137	R:R:L129	R:R:Y128	4.69	No	Yes	0	5	8
138	R:R:V132	R:R:Y128	11.36	No	Yes	0	7	8
139	R:R:C220	R:R:Y128	5.38	No	Yes	0	6	8
140	R:R:F223	R:R:Y128	12.38	No	Yes	0	5	8
141	R:R:I131	R:R:I224	2.94	No	No	0	8	8
142	R:R:R133	R:R:V132	2.62	Yes	No	0	6	7
143	R:R:A136	R:R:R133	6.91	No	Yes	0	4	6
144	R:R:N137	R:R:R133	4.82	No	Yes	0	6	6
145	R:R:R139	R:R:R141	3.2	No	No	0	4	7
146	R:R:L140	R:R:R143	4.86	No	No	0	4	3
147	R:R:L140	R:R:V144	4.47	No	No	0	4	4
148	R:R:L142	R:R:R143	4.86	No	No	0	6	3
149	R:R:S145	R:R:V144	3.23	Yes	No	0	4	4
150	R:R:A147	R:R:G146	1.95	No	No	0	4	7
151	R:R:A161	R:R:V164	1.7	No	No	0	7	4
152	R:R:M165	R:R:V166	7.61	No	No	0	5	4
153	R:R:L167	R:R:M183	5.65	No	No	0	5	5
154	R:R:T169	R:R:Y182	4.99	No	No	0	4	4
155	R:R:D184	R:R:T169	14.45	No	No	0	3	4
156	R:R:G171	R:R:T170	3.64	No	No	0	1	5
157	R:R:C181	R:R:T170	5.07	No	No	0	9	5
158	R:R:D172	R:R:V179	7.3	No	No	0	1	5
159	R:R:E174	R:R:L173	3.98	No	No	0	2	3
160	R:R:L173	R:R:T176	11.79	No	No	0	3	3
161	R:R:E174	R:R:N175	11.83	No	No	0	2	2
162	R:R:N175	R:R:T176	2.92	No	No	0	2	3
163	R:R:K178	R:R:T176	3	No	No	0	2	3
164	R:R:Q180	R:R:Y182	6.76	No	No	0	2	4
165	R:R:M183	R:R:Y185	8.38	No	No	3	5	5
166	R:R:E198	R:R:M183	9.47	No	No	3	4	5
167	R:R:D184	R:R:S186	8.83	No	No	0	3	5
168	R:R:M187	R:R:Y185	4.79	No	No	3	2	5
169	R:R:E198	R:R:Y185	7.86	No	No	3	4	5
170	R:R:E194	R:R:M187	6.77	No	No	0	6	2
171	R:R:E198	R:R:M187	8.12	No	No	3	4	2
172	R:R:S193	R:R:T190	9.59	No	No	0	4	1
173	R:R:E194	R:R:V191	5.7	No	No	0	6	2
174	R:R:S193	R:R:W197	2.47	No	No	0	4	2
175	R:R:E194	R:R:W195	7.63	No	No	0	6	2
176	R:R:G200	R:R:V199	1.84	No	No	0	2	3
177	R:R:G200	R:R:V203	1.84	No	No	0	2	4
178	R:R:G202	R:R:L201	1.71	No	No	0	5	4
179	R:R:G202	R:R:S205	1.86	No	Yes	8	5	4
180	R:R:G202	R:R:T206	3.64	No	No	8	5	5
181	R:R:S205	R:R:T206	3.2	Yes	No	8	4	5
182	R:R:T206	R:R:T207	3.14	No	No	0	5	3
183	R:R:G209	R:R:V208	3.68	No	No	0	5	5
184	R:R:G209	R:R:P213	4.06	No	Yes	0	5	9
185	R:R:F210	R:R:M262	3.73	No	No	0	8	5
186	R:R:F210	R:R:H265	29.41	No	No	0	8	8
187	R:R:P213	R:R:V212	5.3	Yes	No	0	9	6
188	R:R:F214	R:R:L218	12.18	No	No	0	6	4
189	R:R:F214	R:R:F257	4.29	No	No	0	6	8
190	R:R:I216	R:R:T219	3.04	No	No	0	6	4
191	R:R:C220	R:R:Y221	4.03	No	Yes	9	6	8
192	R:R:I250	R:R:Y221	8.46	No	Yes	0	7	8
193	R:R:L253	R:R:Y221	3.52	No	Yes	0	7	8
194	R:R:V254	R:R:Y221	2.52	No	Yes	0	7	8
195	R:R:F222	R:R:F223	2.14	No	No	0	3	5
196	R:R:F223	R:R:Q226	5.86	No	No	0	5	3
197	R:R:I224	R:R:T227	3.04	No	No	0	8	4
198	R:R:Q226	R:R:T227	7.09	No	No	0	3	4
199	R:R:F232	R:R:I228	10.05	Yes	No	0	4	8
200	R:R:F232	R:R:H231	2.26	Yes	No	0	4	5
201	R:R:F232	R:R:R243	2.14	Yes	No	0	4	6
202	R:R:K234	R:R:R236	7.43	No	No	0	3	2
203	R:R:E235	R:R:L240	7.95	No	No	0	4	4
204	R:R:G239	R:R:R236	4.5	No	No	0	4	2
205	R:R:E238	R:R:I237	10.93	No	No	0	4	3
206	R:R:G239	R:R:K242	3.49	No	No	0	4	5
207	R:R:L240	R:R:R241	2.43	No	No	0	4	4
208	R:R:K242	R:R:R245	2.48	No	No	0	5	7
209	R:R:L247	R:R:R244	3.64	No	No	0	6	5
210	R:R:I249	R:R:S248	4.64	No	No	0	7	6
211	R:R:F312	R:R:I249	12.56	No	No	0	6	7
212	R:R:L253	R:R:L308	2.77	No	No	0	7	8
213	R:R:C260	R:R:V300	1.71	No	No	0	7	5
214	R:R:C260	R:R:N301	11.02	No	Yes	0	7	9
215	R:R:H265	R:R:W261	8.46	No	Yes	0	8	9
216	R:R:S298	R:R:W261	2.47	No	Yes	0	7	9
217	R:R:N301	R:R:W261	10.17	Yes	Yes	0	9	9
218	R:R:C294	R:R:P263	3.77	No	No	10	6	9
219	R:R:I297	R:R:P263	5.08	No	No	10	6	9
220	R:R:H265	R:R:Y264	5.44	No	No	0	8	6
221	R:R:K268	R:R:Y264	14.33	No	No	1	5	6
222	L:L:?1	R:R:Y264	15.19	Yes	No	1	0	6
223	R:R:F291	R:R:V267	2.62	No	No	0	4	4
224	R:R:C294	R:R:V267	1.71	No	No	0	6	4
225	L:L:?1	R:R:K268	3.05	Yes	No	1	0	5
226	R:R:M272	R:R:T269	3.01	No	No	0	5	6
227	R:R:F283	R:R:L270	2.44	Yes	No	0	3	5
228	R:R:S275	R:R:Y271	10.17	No	No	0	4	4
229	L:L:?1	R:R:Y271	8.44	Yes	No	0	0	4
230	R:R:G274	R:R:L273	3.42	No	No	0	3	4
231	R:R:H278	R:R:L277	3.86	No	No	0	2	1
232	R:R:C281	R:R:W279	3.92	No	Yes	11	8	1
233	R:R:F283	R:R:W279	9.02	Yes	Yes	0	3	1
234	R:R:D284	R:R:W279	5.58	No	Yes	11	4	1
235	R:R:D282	R:R:P280	4.83	No	No	0	2	4
236	R:R:C281	R:R:D284	4.67	No	No	11	8	4
237	R:R:D282	R:R:F283	7.17	No	Yes	0	2	3
238	R:R:F283	R:R:F286	2.14	Yes	No	0	3	1
239	R:R:F283	R:R:L287	2.44	Yes	No	0	3	4
240	R:R:D284	R:R:L287	4.07	No	No	0	4	4
241	R:R:F286	R:R:L285	2.44	No	No	0	1	3
242	R:R:L287	R:R:M288	2.83	No	No	0	4	4
243	R:R:N289	R:R:Y293	10.47	No	No	0	2	5
244	R:R:F291	R:R:P292	4.33	No	No	0	4	4
245	L:L:?1	R:R:F291	15.79	Yes	No	0	0	4
246	R:R:C294	R:R:I297	3.27	No	No	10	6	6
247	R:R:S298	R:R:T295	3.2	No	Yes	0	7	5
248	R:R:T295	R:R:Y299	7.49	Yes	Yes	1	5	7
249	L:L:?1	R:R:T295	2.12	Yes	Yes	1	0	5
250	R:R:C296	R:R:I297	3.27	No	No	0	5	6
251	R:R:C303	R:R:V300	1.71	No	No	0	7	5
252	R:R:L308	R:R:Y309	4.69	No	Yes	0	8	9
253	R:R:F312	R:R:L308	3.65	No	No	0	6	8
254	R:R:D313	R:R:Y309	5.75	No	Yes	0	8	9
255	R:R:F311	R:R:F312	11.79	No	No	0	6	6
256	R:R:D313	R:R:P314	4.83	No	No	5	8	5
257	R:R:D313	R:R:R315	15.48	No	No	5	8	7
258	R:R:P314	R:R:R315	7.21	No	No	5	5	7
259	R:R:A147	R:R:T150	1.68	No	No	0	4	6
260	R:R:M162	R:R:P163	1.68	No	No	0	4	8
261	R:R:S204	R:R:S205	1.63	No	Yes	0	4	4
262	R:R:N305	R:R:P306	1.63	No	No	0	9	9
263	R:R:A130	R:R:I131	1.62	No	No	0	8	8
264	R:R:A158	R:R:M162	1.61	No	No	0	4	4
265	R:R:V148	R:R:V152	1.6	No	No	0	3	2
266	R:R:S192	R:R:T190	1.6	No	No	0	2	1
267	R:R:V211	R:R:V212	1.6	No	No	0	4	6
268	R:R:V251	R:R:V252	1.6	No	No	0	3	5
269	R:R:V251	R:R:V255	1.6	No	No	0	3	4
270	R:R:T52	R:R:V53	1.59	No	No	0	7	6
271	R:R:T81	R:R:V80	1.59	Yes	No	0	7	4
272	R:R:C119	R:R:L153	1.59	No	No	0	7	6
273	R:R:T207	R:R:V203	1.59	No	No	0	3	4
274	R:R:T215	R:R:V211	1.59	No	No	0	2	4
275	R:R:A258	R:R:L259	1.58	No	No	0	5	5
276	R:R:I249	R:R:V252	1.54	No	No	0	7	5
277	R:R:I290	R:R:V267	1.54	No	No	0	4	4
278	R:R:M272	R:R:V203	1.52	No	No	0	5	4
279	R:R:L37	R:R:V38	1.49	No	No	0	5	7
280	R:R:L153	R:R:V152	1.49	No	No	0	6	2
281	R:R:L259	R:R:V255	1.49	No	No	0	5	4
282	R:R:L48	R:R:T52	1.47	No	No	0	5	7
283	R:R:L266	R:R:T269	1.47	No	No	0	6	6
284	R:R:D94	R:R:V179	1.46	No	No	0	4	5
285	R:R:G28	R:R:Y293	1.45	No	No	0	3	5
286	R:R:P134	R:R:R133	1.44	No	Yes	0	8	6
287	R:R:I228	R:R:L247	1.43	No	No	0	8	6
288	R:R:I250	R:R:L247	1.43	No	No	0	7	6
289	R:R:G274	R:R:W279	1.41	No	Yes	0	3	1
290	R:R:L104	R:R:L108	1.38	No	Yes	0	5	4
291	R:R:A138	R:R:R139	1.38	No	No	0	5	4
292	R:R:L304	R:R:N301	1.37	No	Yes	0	6	9
293	R:R:D184	R:R:L167	1.36	No	No	0	3	5
294	R:R:E235	R:R:K234	1.35	No	No	0	4	3
295	R:R:R55	R:R:S56	1.32	No	No	0	6	5
296	R:R:R141	R:R:S145	1.32	No	Yes	0	7	4
297	R:R:F232	R:R:L246	1.22	Yes	No	0	4	7
298	R:R:F307	R:R:L304	1.22	No	No	0	6	6
299	R:R:F257	R:R:N301	1.21	No	Yes	0	8	9
300	R:R:L277	R:R:W279	1.14	No	Yes	0	1	1
301	R:R:F232	R:R:R236	1.07	Yes	No	0	4	2
302	L:L:?1	R:R:M288	1.02	Yes	No	0	0	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I31	7.51	4	1	6
2	R:R:Y35	8.625	6	1	7
3	R:R:N46	7.675	4	4	9
4	R:R:V49	2.84	4	4	8
5	R:R:F67	4.37	4	0	7
6	R:R:F78	5.2625	4	0	6
7	R:R:T81	4.0475	4	1	7
8	R:R:L82	5.518	5	1	7
9	R:R:W85	7.3125	4	1	6
10	R:R:R91	5.9075	4	0	3
11	R:R:W95	6.41429	7	2	8
12	R:R:F97	7.9575	4	2	6
13	R:R:K103	5.785	4	0	7
14	R:R:Y107	4.59	4	7	5
15	R:R:L108	3.945	4	0	4
16	R:R:F110	7.5	4	1	5
17	R:R:V111	2.6425	4	7	4
18	R:R:N112	6.165	4	0	8
19	R:R:Y114	4.846	5	0	6
20	R:R:T121	3.22	4	0	7
21	R:R:Y128	8.4525	4	0	8
22	R:R:R133	3.9475	4	0	6
23	R:R:S145	2.6875	4	6	4
24	R:R:S205	2.3075	4	8	4
25	R:R:P213	4.0975	4	0	9
26	R:R:Y221	5.74	5	9	8
27	R:R:F232	3.348	5	0	4
28	R:R:W261	6.1475	4	0	9
29	R:R:W279	4.214	5	11	1
30	R:R:F283	4.642	5	0	3
31	R:R:T295	5.3875	4	1	5
32	R:R:Y299	5.786	5	1	7
33	R:R:N301	5.9425	4	0	9
34	R:R:Y309	7.1175	4	0	9
35	L:L:?1	8.283	10	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:V38	R:R:Y299	11.1389	3.79	No	Yes	0	7	7
2	L:L:?1	R:R:T295	20.2213	2.12	Yes	Yes	1	0	5
3	L:L:?1	R:R:W85	42.4892	13.94	Yes	Yes	1	0	6
4	R:R:T81	R:R:W85	17.0486	2.43	Yes	Yes	1	7	6
5	R:R:T81	R:R:V80	26.7479	1.59	Yes	No	0	7	4
6	R:R:L76	R:R:V80	25.2301	2.98	No	No	0	7	4
7	R:R:L76	R:R:N46	23.7466	8.24	No	Yes	0	7	9
8	R:R:N46	R:R:V49	17.6753	2.96	Yes	Yes	4	9	8
9	R:R:T52	R:R:V49	11.5795	3.17	No	Yes	0	7	8
10	R:R:F78	R:R:Y299	23.0121	6.19	Yes	Yes	0	6	7
11	R:R:F78	R:R:N112	54.6269	7.25	Yes	Yes	0	6	8
12	R:R:N112	R:R:V111	66.2701	2.96	Yes	Yes	0	8	4
13	R:R:A157	R:R:V111	100	1.7	No	Yes	0	7	4
14	R:R:A115	R:R:A157	99.4663	1.79	No	No	0	7	7
15	R:R:A115	R:R:A74	97.8065	1.79	No	No	0	7	8
16	R:R:A74	R:R:S116	97.2337	1.71	No	No	0	8	9
17	R:R:S116	R:R:V117	96.651	3.23	No	No	0	9	7
18	R:R:P213	R:R:V117	96.0586	3.53	Yes	No	0	9	7
19	R:R:P213	R:R:T121	92.2983	3.5	Yes	Yes	0	9	7
20	R:R:M217	R:R:T121	89.5956	4.52	No	Yes	0	8	7
21	R:R:M217	R:R:S124	88.8954	6.13	No	No	0	8	9
22	R:R:S124	R:R:Y221	59.4154	10.17	No	Yes	9	9	8
23	R:R:L253	R:R:Y221	44.3008	3.52	No	Yes	0	7	8
24	R:R:L253	R:R:L308	43.2139	2.77	No	No	0	7	8
25	R:R:L308	R:R:Y309	32.4765	4.69	No	Yes	0	8	9
26	R:R:I68	R:R:Y309	11.5501	14.51	No	Yes	0	8	9
27	R:R:D65	R:R:I68	10.14	2.8	No	No	0	8	8
28	R:R:F67	R:R:L123	11.0556	3.65	Yes	No	0	7	8
29	R:R:L123	R:R:Y309	16.0497	3.52	No	Yes	0	8	9
30	R:R:F125	R:R:V144	12.9113	5.24	No	No	0	6	4
31	R:R:F125	R:R:L129	14.0668	9.74	No	No	0	6	5
32	R:R:L129	R:R:Y128	15.3643	4.69	No	Yes	0	5	8
33	R:R:C220	R:R:Y128	30.9832	5.38	No	Yes	0	6	8
34	R:R:C220	R:R:S124	28.7652	5.16	No	No	9	6	9
35	R:R:F118	R:R:L153	13.8856	3.65	No	No	0	5	6
36	R:R:F118	R:R:Y114	15.5259	2.06	No	Yes	0	5	6
37	R:R:F110	R:R:Y114	22.6449	3.09	Yes	Yes	0	5	6
38	L:L:?1	R:R:F110	12.2846	11.4	Yes	Yes	1	0	5
39	R:R:M113	R:R:Y114	15.8784	5.99	No	Yes	0	7	6
40	R:R:F78	R:R:M113	26.8459	4.98	Yes	No	0	6	7
41	R:R:L108	R:R:N112	16.9164	2.75	Yes	Yes	0	4	8
42	R:R:R168	R:R:W85	38.0043	3	No	Yes	0	5	6
43	R:R:K103	R:R:R168	36.085	2.48	Yes	No	0	7	5
44	R:R:K103	R:R:T99	55.3662	3	Yes	No	0	7	3
45	R:R:G98	R:R:T99	54.2401	1.82	No	No	0	8	3
46	R:R:G98	R:R:W95	53.1042	2.81	No	Yes	0	8	8
47	R:R:P96	R:R:W95	43.5321	5.4	No	Yes	2	4	8
48	R:R:P96	R:R:R91	42.7683	11.53	No	Yes	0	4	3
49	R:R:R91	R:R:Y88	28.5497	2.06	Yes	No	0	3	5
50	R:R:Q180	R:R:Y88	24.4663	4.51	No	No	0	2	5
51	R:R:D94	R:R:R91	13.4792	3.57	No	Yes	0	4	3
52	R:R:K103	R:R:V166	25.6904	15.18	Yes	No	0	7	4
53	R:R:V111	R:R:Y107	28.4078	2.52	Yes	Yes	7	4	5
54	R:R:A161	R:R:V111	12.4951	3.39	No	Yes	7	7	4
55	R:R:A161	R:R:V164	14.0276	1.7	No	No	0	7	4
56	R:R:F110	R:R:V164	14.2382	10.49	Yes	No	0	5	4
57	R:R:M165	R:R:Y107	26.2779	8.38	No	Yes	0	5	5
58	R:R:S205	R:R:Y114	21.9301	2.54	Yes	Yes	0	4	6
59	R:R:N301	R:R:W261	19.1295	10.17	Yes	Yes	0	9	9
60	R:R:Q180	R:R:Y182	23.0856	6.76	No	No	0	2	4
61	R:R:T169	R:R:Y182	21.6951	4.99	No	No	0	4	4
62	R:R:D184	R:R:T169	20.2948	14.45	No	No	0	3	4
63	R:R:D184	R:R:L167	17.5382	1.36	No	No	0	3	5
64	R:R:L167	R:R:M183	16.1085	5.65	No	No	0	5	5
65	R:R:T207	R:R:V203	11.0899	1.59	No	No	0	3	4
66	R:R:T206	R:R:T207	12.9211	3.14	No	No	0	5	3
67	R:R:S205	R:R:T206	14.6641	3.2	Yes	No	8	4	5
68	R:R:I250	R:R:Y221	22.3365	8.46	No	Yes	0	7	8
69	R:R:F232	R:R:I228	17.1171	10.05	Yes	No	0	4	8
70	R:R:I228	R:R:L247	18.3754	1.43	No	No	0	8	6
71	R:R:I250	R:R:L247	21.0928	1.43	No	No	0	7	6
72	R:R:F232	R:R:R236	11.555	1.07	Yes	No	0	4	2
73	R:R:F312	R:R:I249	10.1204	12.56	No	No	0	6	7
74	R:R:F312	R:R:L308	12.9309	3.65	No	No	0	6	8
75	R:R:F283	R:R:L287	15.8637	2.44	Yes	No	0	3	4
76	R:R:L287	R:R:M288	27.3355	2.83	No	No	0	4	4
77	L:L:?1	R:R:M288	28.584	1.02	Yes	No	0	0	4
78	R:R:D284	R:R:L287	10.1694	4.07	No	No	0	4	4
79	R:R:L82	R:R:Y299	11.6285	3.52	Yes	Yes	1	7	7
80	L:L:?1	R:R:F78	32.736	2.63	Yes	Yes	0	0	6
81	R:R:L108	R:R:T81	16.4659	7.37	Yes	Yes	0	4	7
82	R:R:M165	R:R:V166	25.4896	7.61	No	No	0	5	4
83	R:R:M113	R:R:W261	14.6641	3.49	No	Yes	0	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:T295	R:R:Y35	8.74	1	Yes	Yes	5	7	1	2
R:R:Y299	R:R:Y35	7.94	1	Yes	Yes	7	7	2	2
R:R:F78	R:R:N112	7.25	0	Yes	Yes	6	8	1	2
R:R:F78	R:R:M113	4.98	0	Yes	No	6	7	1	2
R:R:F78	R:R:Y299	6.19	0	Yes	Yes	6	7	1	2
L:L:?1	R:R:F78	2.63	1	Yes	Yes	0	6	0	1
R:R:T81	R:R:W85	2.43	1	Yes	Yes	7	6	2	1
R:R:S105	R:R:T81	4.8	1	No	Yes	5	7	2	2
R:R:L108	R:R:T81	7.37	0	Yes	Yes	4	7	2	2
R:R:S105	R:R:W85	9.88	1	No	Yes	5	6	2	1
R:R:R168	R:R:W85	3	0	No	Yes	5	6	2	1
L:L:?1	R:R:W85	13.94	1	Yes	Yes	0	6	0	1
R:R:I109	R:R:L108	4.28	1	No	Yes	6	4	1	2
R:R:L108	R:R:N112	2.75	0	Yes	Yes	4	8	2	2
R:R:F110	R:R:I109	5.02	1	Yes	No	5	6	1	1
L:L:?1	R:R:I109	9.25	1	Yes	No	0	6	0	1
R:R:F110	R:R:Y114	3.09	1	Yes	Yes	5	6	1	2
R:R:F110	R:R:V164	10.49	1	Yes	No	5	4	1	2
L:L:?1	R:R:F110	11.4	1	Yes	Yes	0	5	0	1
R:R:M113	R:R:Y114	5.99	0	No	Yes	7	6	2	2
R:R:H265	R:R:Y264	5.44	0	No	No	8	6	2	1
R:R:K268	R:R:Y264	14.33	1	No	No	5	6	1	1
L:L:?1	R:R:Y264	15.19	1	Yes	No	0	6	0	1
R:R:F291	R:R:V267	2.62	0	No	No	4	4	1	2
L:L:?1	R:R:K268	3.05	1	Yes	No	0	5	0	1
R:R:S275	R:R:Y271	10.17	0	No	No	4	4	2	1
L:L:?1	R:R:Y271	8.44	1	Yes	No	0	4	0	1
R:R:L287	R:R:M288	2.83	0	No	No	4	4	2	1
R:R:F291	R:R:P292	4.33	0	No	No	4	4	1	2
L:L:?1	R:R:F291	15.79	1	Yes	No	0	4	0	1
R:R:S298	R:R:T295	3.2	0	No	Yes	7	5	2	1
R:R:T295	R:R:Y299	7.49	1	Yes	Yes	5	7	1	2
L:L:?1	R:R:T295	2.12	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M288	1.02	1	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7W0M_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.7
Number of Linked Nodes	268
Number of Links	302
Number of Hubs	35
Number of Links mediated by Hubs	134
Number of Communities	11
Number of Nodes involved in Communities	53
Number of Links involved in Communities	65

Path Summary
Number Of Nodes in MetaPath	84
Number Of Links MetaPath	83
Number of Shortest Paths	44719
Length Of Smallest Path	3
Average Path Length	16.1416
Length of Longest Path	40
Minimum Path Strength	1.26667
Average Path Strength	4.77876
Maximum Path Strength	18.935
Minimum Path Correlation	0.7
Average Path Correlation	0.937309
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.94118
Average % Of Corr. Nodes	50.5431
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.1122
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • synapse • cell junction • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • apelin receptor activity • mechanoreceptor activity • electron transport chain • metabolic process • generation of precursor metabolites and energy • apelin receptor signaling pathway • developmental process • heart development • multicellular organism development • multicellular organismal process • anatomical structure development • animal organ development • circulatory system development • system development • atrioventricular valve development • heart valve development • cardiac chamber morphogenesis • heart morphogenesis • ventricular septum development • anatomical structure morphogenesis • cardiac septum development • cardiac septum morphogenesis • ventricular septum morphogenesis • cardiac chamber development • animal organ morphogenesis • cardiac ventricle development • regulation of body fluid levels • regulation of biological quality • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • tube morphogenesis • anatomical structure formation involved in morphogenesis • blood vessel development • regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis • positive regulation of cell population proliferation • endothelial cell proliferation • positive regulation of biological process • positive regulation of endothelial cell proliferation • epithelial cell proliferation • positive regulation of cellular process • positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis • blood vessel endothelial cell proliferation involved in sprouting angiogenesis • positive regulation of epithelial cell proliferation • sprouting angiogenesis • regulation of endothelial cell proliferation • regulation of cell population proliferation • regulation of epithelial cell proliferation • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of metabolic process • embryonic morphogenesis • embryo development • gastrulation • mesenchyme morphogenesis • endocardial cushion morphogenesis • mesenchyme development • tissue development • endocardial cushion formation • tissue morphogenesis • endocardial cushion development • artery development • aorta development • regulation of localization • negative adaptation of signaling pathway • regulation of G protein-coupled receptor internalization • receptor internalization • negative regulation of biological process • regulation of signal transduction • regulation of receptor internalization • vesicle-mediated transport • negative regulation of G protein-coupled receptor signaling pathway • localization • positive regulation of endocytosis • regulation of G protein-coupled receptor signaling pathway • positive regulation of receptor-mediated endocytosis • positive regulation of G protein-coupled receptor internalization • establishment of localization • positive regulation of receptor internalization • regulation of response to stimulus • adaptation of signaling pathway • receptor-mediated endocytosis • import into cell • regulation of cellular component organization • positive regulation of cellular component organization • transport • negative regulation of signaling • desensitization of G protein-coupled receptor signaling pathway • negative regulation of cell communication • cellular component organization • negative regulation of cellular process • cellular component organization or biogenesis • regulation of endocytosis • G protein-coupled receptor internalization • regulation of signaling • regulation of transport • negative regulation of response to stimulus • regulation of receptor-mediated endocytosis • regulation of vesicle-mediated transport • negative regulation of signal transduction • positive regulation of transport • regulation of cell communication • endocytosis • cellular developmental process • vasculogenesis • cell differentiation • regulation of developmental process • regulation of vasculature development • positive regulation of developmental process • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • positive regulation of angiogenesis • positive regulation of vasculature development • regulation of angiogenesis • positive regulation of multicellular organismal process • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • venous blood vessel development • regulation of calcium ion transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • intracellular calcium ion homeostasis • calcium ion transport • positive regulation of monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation homeostasis • monoatomic cation transport • intracellular monoatomic ion homeostasis • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • chemical homeostasis • cellular localization • inorganic ion homeostasis • homeostatic process • monoatomic ion transmembrane transport • calcium ion homeostasis • regulation of monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • metal ion transport • maintenance of location in cell • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • monoatomic ion transport • intracellular chemical homeostasis • positive regulation of release of sequestered calcium ion into cytosol • regulation of metal ion transport • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • sequestering of calcium ion • cellular homeostasis • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • negative regulation of muscle adaptation • system process • striated muscle adaptation • negative regulation of muscle hypertrophy • regulation of system process • regulation of muscle hypertrophy • regulation of cardiac muscle hypertrophy in response to stress • muscle adaptation • cardiac muscle adaptation • regulation of response to stress • response to stress • cardiac muscle hypertrophy • cardiac muscle hypertrophy in response to stress • muscle hypertrophy • regulation of muscle adaptation • negative regulation of cardiac muscle hypertrophy in response to stress • striated muscle hypertrophy • regulation of muscle system process • muscle system process • regulation of cardiac muscle hypertrophy • negative regulation of cardiac muscle adaptation • negative regulation of multicellular organismal process • regulation of cardiac muscle adaptation • negative regulation of cardiac muscle hypertrophy • muscle hypertrophy in response to stress • adult heart development • negative regulation of metabolic process • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of macromolecule metabolic process • positive regulation of cardiac muscle hypertrophy • positive regulation of cardiac muscle hypertrophy in response to stress • positive regulation of response to stimulus • positive regulation of muscle adaptation • positive regulation of cardiac muscle adaptation • positive regulation of muscle hypertrophy • smooth muscle cell differentiation • muscle cell differentiation • muscle structure development • vascular associated smooth muscle cell differentiation • coronary vasculature development • gap junction assembly • regulation of gap junction assembly • regulation of cellular component biogenesis • cellular component biogenesis • regulation of cell junction assembly • cell junction organization • cellular component assembly • cell junction assembly • cell-cell junction assembly • cell-cell junction organization • pattern specification process • embryonic heart tube development • embryonic heart tube morphogenesis • heart looping • determination of bilateral symmetry • epithelial tube morphogenesis • embryonic organ development • determination of left/right symmetry • specification of symmetry • embryonic organ morphogenesis • epithelium development • morphogenesis of an epithelium • determination of heart left/right asymmetry • regionalization • left/right pattern formation • periplasmic space • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	8EH
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	8EH
Name	(1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide
Synonyms
Identifier
Formula	C24 H27 N7 O5 S
Molecular Weight	525.58
SMILES
PubChem	122701908
Formal Charge	0
Total Atoms	64
Total Chiral Atoms	2
Total Bonds	67
Total Aromatic Bonds	23


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35414
Sequence	>7W0M_nogp_Chain_R S S G A L I P A I Y M L V F L L G T T G N G L V L W T V F R S S R E K R R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D Y D W P F G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R P V A N A R L R L R V S G A V A T A V L W V L A A L L A M P V M V L R T T G D L E N T T K V Q C Y M D Y S M V A T V S S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R K E R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L L H W P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XZF	A	Peptide	Apelin	Apelin	Homo sapiens	WN561	-	Gi1/β1/γ2	3	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZF (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	WN561	-		3	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZG	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-	Gi1/β1/γ2	3.2	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZG (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-		3.2	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZH	A	Peptide	Apelin	Apelin	Homo sapiens	MM07	-	Gi1/β1/γ2	2.06	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZH (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	MM07	-		2.06	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZJ	A	Peptide	Apelin	Apelin	Homo sapiens	WN353	-	Gi1/β1/γ2	3	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZJ (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	WN353	-		3	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	5VBL	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin mimetic peptide agonist	-	-	2.6	2017-05-31	doi.org/10.1016/j.str.2017.04.008
	8Z74	A	Peptide	Apelin	Apelin	Homo sapiens	Agonistic antibody	-	-	3.01	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8Z7J	A	Peptide	Apelin	Apelin	Homo sapiens	Agonistic antibody	-	Gi1/β1/γ2	3.12	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8Z7J (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Agonistic antibody	-		3.12	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	7SUS	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-	-	2.7	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0L	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-	Gi1/β1/γ2	3.57	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0L (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-		3.57	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0M	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-	Gi1/β1/γ2	3.71	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0M (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-		3.71	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0N	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-	Gi1/β1/γ2	4.21	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0N (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-		4.21	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0O	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-	Gi1/β1/γ2	3.78	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0O (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-		3.78	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0P	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-	Gi1/β1/γ2	3.16	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0P (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-		3.16	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	6KNM	A	Peptide	Apelin	Apelin	Homo sapiens	JN241-9	-	-	3.2	2020-01-29	doi.org/10.1126/sciadv.aax7379
	8XZI	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-	Gi1/β1/γ2	2.7	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZI (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-		2.7	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8S4D	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-	-	2.58	2024-12-04	doi.org/10.1038/s41467-024-55381-w
	8XQE	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-	Gi1/β1/γ2	3.48	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQE (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-		3.48	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQF	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-	Gi1/β1/γ2	3.13	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQF (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-		3.13	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQI	A	Peptide	Apelin	Apelin	Homo sapiens	-	-	-	3.25	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQJ	A	Peptide	Apelin	Apelin	Homo sapiens	JN241	-	-	2.95	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	9JH3	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-	Gi1/β1/γ2	2.93	2025-04-23	doi.org/10.1073/pnas.2423432122
	9JH3 (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-		2.93	2025-04-23	doi.org/10.1073/pnas.2423432122

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