psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N289	R:R:S26	5.96	No	No	0	2	3
2	R:R:I31	R:R:P32	5.08	Yes	No	1	6	5
3	R:R:I31	R:R:I34	5.89	Yes	No	1	6	5
4	R:R:I31	R:R:Y35	14.51	Yes	Yes	1	6	7
5	R:R:I31	R:R:T89	4.56	Yes	No	1	6	5
6	R:R:P32	R:R:T89	6.99	No	No	1	5	5
7	R:R:I34	R:R:Y35	4.84	No	Yes	1	5	7
8	R:R:C296	R:R:I34	4.91	No	No	0	5	5
9	R:R:L82	R:R:Y35	11.72	Yes	Yes	1	7	7
10	R:R:A86	R:R:Y35	4	No	Yes	0	6	7
11	R:R:T295	R:R:Y35	8.74	Yes	Yes	1	5	7
12	R:R:Y299	R:R:Y35	7.94	Yes	Yes	1	7	7
13	R:R:M36	R:R:P83	3.35	No	No	0	3	9
14	R:R:V38	R:R:Y299	3.79	No	Yes	0	7	7
15	R:R:C303	R:R:V38	1.71	No	No	0	7	7
16	R:R:F39	R:R:T43	11.67	No	No	0	6	5
17	R:R:F39	R:R:V79	3.93	No	No	1	6	6
18	R:R:F39	R:R:L82	6.09	No	Yes	1	6	7
19	R:R:L40	R:R:T44	2.95	No	No	0	5	4
20	R:R:G42	R:R:L41	1.71	No	No	0	8	5
21	R:R:C303	R:R:G42	3.92	No	No	0	7	8
22	R:R:G45	R:R:T44	3.64	No	No	0	8	4
23	R:R:G45	R:R:P306	4.06	No	No	0	8	9
24	R:R:N46	R:R:V49	2.96	Yes	Yes	4	9	8
25	R:R:A72	R:R:N46	4.69	No	Yes	4	8	9
26	R:R:D75	R:R:N46	14.81	No	Yes	0	9	9
27	R:R:L76	R:R:N46	8.24	No	Yes	0	7	9
28	R:R:G47	R:R:L50	5.13	No	No	0	3	7
29	R:R:T52	R:R:V49	3.17	No	Yes	0	7	8
30	R:R:A72	R:R:V49	1.7	No	Yes	4	8	8
31	R:R:P306	R:R:V49	3.53	No	Yes	0	9	8
32	R:R:F54	R:R:L50	6.09	No	No	0	3	7
33	R:R:R55	R:R:W51	3	No	No	0	6	3
34	R:R:F54	R:R:V53	3.93	No	No	0	3	6
35	R:R:F54	R:R:R58	4.28	No	No	0	3	6
36	R:R:R61	R:R:S56	7.91	No	No	0	6	5
37	R:R:K60	R:R:S57	9.18	No	No	0	6	6
38	R:R:K60	R:R:R61	2.48	No	No	0	6	6
39	R:R:D65	R:R:R61	9.53	No	No	0	8	6
40	R:R:A64	R:R:R62	2.77	No	No	0	8	7
41	R:R:R315	R:R:R62	6.4	No	No	0	7	7
42	R:R:D126	R:R:S63	4.42	No	No	6	8	6
43	R:R:S145	R:R:S63	3.26	Yes	No	6	4	6
44	R:R:D65	R:R:I68	2.8	No	No	0	8	8
45	R:R:F67	R:R:I66	6.28	Yes	No	0	7	5
46	R:R:I66	R:R:T150	9.12	No	No	0	5	6
47	R:R:F67	R:R:L123	3.65	Yes	No	0	7	8
48	R:R:D126	R:R:F67	4.78	No	Yes	0	8	7
49	R:R:A149	R:R:F67	2.77	No	Yes	0	5	7
50	R:R:I68	R:R:Y309	14.51	No	Yes	0	8	9
51	R:R:C119	R:R:S70	5.16	No	No	0	7	9
52	R:R:C119	R:R:L71	4.76	No	No	0	7	9
53	R:R:L71	R:R:N305	6.87	No	No	0	9	9
54	R:R:V73	R:R:W154	2.45	No	No	0	5	9
55	R:R:A115	R:R:A74	1.79	No	No	0	7	8
56	R:R:A74	R:R:S116	1.71	No	No	0	8	9
57	R:R:D75	R:R:S302	8.83	No	No	0	9	8
58	R:R:L76	R:R:V80	2.98	No	No	0	7	4
59	R:R:N112	R:R:T77	11.7	Yes	No	0	8	7
60	R:R:F78	R:R:N112	7.25	Yes	Yes	0	6	8
61	R:R:F78	R:R:M113	4.98	Yes	No	0	6	7
62	R:R:F78	R:R:Y299	6.19	Yes	Yes	0	6	7
63	L:L:?1	R:R:F78	2.63	Yes	Yes	0	0	6
64	R:R:L82	R:R:V79	2.98	Yes	No	1	7	6
65	R:R:T81	R:R:W85	2.43	Yes	Yes	1	7	6
66	R:R:S105	R:R:T81	4.8	No	Yes	1	5	7
67	R:R:L108	R:R:T81	7.37	Yes	Yes	0	4	7
68	R:R:L82	R:R:P83	3.28	Yes	No	0	7	9
69	R:R:L82	R:R:Y299	3.52	Yes	Yes	1	7	7
70	R:R:L84	R:R:W95	5.69	No	Yes	2	6	8
71	R:R:F97	R:R:L84	7.31	Yes	No	2	6	6
72	R:R:F101	R:R:L84	2.44	No	No	2	5	6
73	R:R:S105	R:R:W85	9.88	No	Yes	1	5	6
74	R:R:R168	R:R:W85	3	No	Yes	0	5	6
75	L:L:?1	R:R:W85	13.94	Yes	Yes	1	0	6
76	R:R:R91	R:R:T87	6.47	Yes	No	0	3	4
77	R:R:R91	R:R:Y88	2.06	Yes	No	0	3	5
78	R:R:Y88	R:R:Y93	11.91	No	No	0	5	4
79	R:R:Q180	R:R:Y88	4.51	No	No	0	2	5
80	R:R:D94	R:R:R91	3.57	No	Yes	0	4	3
81	R:R:P96	R:R:R91	11.53	No	Yes	0	4	3
82	R:R:D92	R:R:Y93	2.3	No	No	0	6	4
83	R:R:D94	R:R:K178	15.21	No	No	0	4	2
84	R:R:P96	R:R:W95	5.4	No	Yes	2	4	8
85	R:R:F97	R:R:W95	8.02	Yes	Yes	2	6	8
86	R:R:G98	R:R:W95	2.81	No	Yes	0	8	8
87	R:R:F101	R:R:W95	6.01	No	Yes	2	5	8
88	R:R:C102	R:R:W95	11.75	No	Yes	2	9	8
89	R:R:C181	R:R:W95	5.22	No	Yes	2	9	8
90	R:R:F97	R:R:P96	5.78	Yes	No	2	6	4
91	R:R:F101	R:R:F97	10.72	No	Yes	2	5	6
92	R:R:G98	R:R:T99	1.82	No	No	0	8	3
93	R:R:K103	R:R:T99	3	Yes	No	0	7	3
94	R:R:F100	R:R:K103	2.48	No	Yes	0	1	7
95	R:R:C102	R:R:C181	7.28	No	No	2	9	9
96	R:R:K103	R:R:V166	15.18	Yes	No	0	7	4
97	R:R:K103	R:R:R168	2.48	Yes	No	0	7	5
98	R:R:R168	R:R:S106	13.18	No	No	0	5	5
99	R:R:V111	R:R:Y107	2.52	Yes	Yes	7	4	5
100	R:R:A161	R:R:Y107	2.67	No	Yes	7	7	5
101	R:R:M162	R:R:Y107	4.79	No	Yes	0	4	5
102	R:R:M165	R:R:Y107	8.38	No	Yes	0	5	5
103	R:R:I109	R:R:L108	4.28	No	Yes	0	6	4
104	R:R:L108	R:R:N112	2.75	Yes	Yes	0	4	8
105	R:R:F110	R:R:I109	5.02	Yes	No	1	5	6
106	L:L:?1	R:R:I109	9.25	Yes	No	1	0	6
107	R:R:F110	R:R:Y114	3.09	Yes	Yes	0	5	6
108	R:R:F110	R:R:V164	10.49	Yes	No	0	5	4
109	L:L:?1	R:R:F110	11.4	Yes	Yes	1	0	5
110	R:R:N112	R:R:V111	2.96	Yes	Yes	0	8	4
111	R:R:A157	R:R:V111	1.7	No	Yes	0	7	4
112	R:R:A161	R:R:V111	3.39	No	Yes	7	7	4
113	R:R:M113	R:R:Y114	5.99	No	Yes	0	7	6
114	R:R:M113	R:R:W261	3.49	No	Yes	0	7	9
115	R:R:F118	R:R:Y114	2.06	No	Yes	0	5	6
116	R:R:L160	R:R:Y114	10.55	No	Yes	0	4	6
117	R:R:S205	R:R:Y114	2.54	Yes	Yes	0	4	6
118	R:R:A115	R:R:W154	2.59	No	No	0	7	9
119	R:R:A115	R:R:A157	1.79	No	No	0	7	7
120	R:R:S116	R:R:V117	3.23	No	No	0	9	7
121	R:R:P213	R:R:V117	3.53	Yes	No	0	9	7
122	R:R:F118	R:R:L153	3.65	No	No	0	5	6
123	R:R:F257	R:R:L120	2.44	No	No	0	8	8
124	R:R:G122	R:R:T121	1.82	No	Yes	0	6	7
125	R:R:P213	R:R:T121	3.5	Yes	Yes	0	9	7
126	R:R:I216	R:R:T121	3.04	No	Yes	0	6	7
127	R:R:M217	R:R:T121	4.52	No	Yes	0	8	7
128	R:R:L123	R:R:R127	6.07	No	No	0	8	9
129	R:R:L123	R:R:Y309	3.52	No	Yes	0	8	9
130	R:R:M217	R:R:S124	6.13	No	No	0	8	9
131	R:R:C220	R:R:S124	5.16	No	No	9	6	9
132	R:R:S124	R:R:Y221	10.17	No	Yes	9	9	8
133	R:R:F125	R:R:L129	9.74	No	No	0	6	5
134	R:R:F125	R:R:V144	5.24	No	No	0	6	4
135	R:R:D126	R:R:S145	2.94	No	Yes	6	8	4
136	R:R:I131	R:R:R127	3.76	No	No	0	8	9
137	R:R:L129	R:R:Y128	4.69	No	Yes	0	5	8
138	R:R:V132	R:R:Y128	11.36	No	Yes	0	7	8
139	R:R:C220	R:R:Y128	5.38	No	Yes	0	6	8
140	R:R:F223	R:R:Y128	12.38	No	Yes	0	5	8
141	R:R:I131	R:R:I224	2.94	No	No	0	8	8
142	R:R:R133	R:R:V132	2.62	Yes	No	0	6	7
143	R:R:A136	R:R:R133	6.91	No	Yes	0	4	6
144	R:R:N137	R:R:R133	4.82	No	Yes	0	6	6
145	R:R:R139	R:R:R141	3.2	No	No	0	4	7
146	R:R:L140	R:R:R143	4.86	No	No	0	4	3
147	R:R:L140	R:R:V144	4.47	No	No	0	4	4
148	R:R:L142	R:R:R143	4.86	No	No	0	6	3
149	R:R:S145	R:R:V144	3.23	Yes	No	0	4	4
150	R:R:A147	R:R:G146	1.95	No	No	0	4	7
151	R:R:A161	R:R:V164	1.7	No	No	0	7	4
152	R:R:M165	R:R:V166	7.61	No	No	0	5	4
153	R:R:L167	R:R:M183	5.65	No	No	0	5	5
154	R:R:T169	R:R:Y182	4.99	No	No	0	4	4
155	R:R:D184	R:R:T169	14.45	No	No	0	3	4
156	R:R:G171	R:R:T170	3.64	No	No	0	1	5
157	R:R:C181	R:R:T170	5.07	No	No	0	9	5
158	R:R:D172	R:R:V179	7.3	No	No	0	1	5
159	R:R:E174	R:R:L173	3.98	No	No	0	2	3
160	R:R:L173	R:R:T176	11.79	No	No	0	3	3
161	R:R:E174	R:R:N175	11.83	No	No	0	2	2
162	R:R:N175	R:R:T176	2.92	No	No	0	2	3
163	R:R:K178	R:R:T176	3	No	No	0	2	3
164	R:R:Q180	R:R:Y182	6.76	No	No	0	2	4
165	R:R:M183	R:R:Y185	8.38	No	No	3	5	5
166	R:R:E198	R:R:M183	9.47	No	No	3	4	5
167	R:R:D184	R:R:S186	8.83	No	No	0	3	5
168	R:R:M187	R:R:Y185	4.79	No	No	3	2	5
169	R:R:E198	R:R:Y185	7.86	No	No	3	4	5
170	R:R:E194	R:R:M187	6.77	No	No	0	6	2
171	R:R:E198	R:R:M187	8.12	No	No	3	4	2
172	R:R:S193	R:R:T190	9.59	No	No	0	4	1
173	R:R:E194	R:R:V191	5.7	No	No	0	6	2
174	R:R:S193	R:R:W197	2.47	No	No	0	4	2
175	R:R:E194	R:R:W195	7.63	No	No	0	6	2
176	R:R:G200	R:R:V199	1.84	No	No	0	2	3
177	R:R:G200	R:R:V203	1.84	No	No	0	2	4
178	R:R:G202	R:R:L201	1.71	No	No	0	5	4
179	R:R:G202	R:R:S205	1.86	No	Yes	8	5	4
180	R:R:G202	R:R:T206	3.64	No	No	8	5	5
181	R:R:S205	R:R:T206	3.2	Yes	No	8	4	5
182	R:R:T206	R:R:T207	3.14	No	No	0	5	3
183	R:R:G209	R:R:V208	3.68	No	No	0	5	5
184	R:R:G209	R:R:P213	4.06	No	Yes	0	5	9
185	R:R:F210	R:R:M262	3.73	No	No	0	8	5
186	R:R:F210	R:R:H265	29.41	No	No	0	8	8
187	R:R:P213	R:R:V212	5.3	Yes	No	0	9	6
188	R:R:F214	R:R:L218	12.18	No	No	0	6	4
189	R:R:F214	R:R:F257	4.29	No	No	0	6	8
190	R:R:I216	R:R:T219	3.04	No	No	0	6	4
191	R:R:C220	R:R:Y221	4.03	No	Yes	9	6	8
192	R:R:I250	R:R:Y221	8.46	No	Yes	0	7	8
193	R:R:L253	R:R:Y221	3.52	No	Yes	0	7	8
194	R:R:V254	R:R:Y221	2.52	No	Yes	0	7	8
195	R:R:F222	R:R:F223	2.14	No	No	0	3	5
196	R:R:F223	R:R:Q226	5.86	No	No	0	5	3
197	R:R:I224	R:R:T227	3.04	No	No	0	8	4
198	R:R:Q226	R:R:T227	7.09	No	No	0	3	4
199	R:R:F232	R:R:I228	10.05	Yes	No	0	4	8
200	R:R:F232	R:R:H231	2.26	Yes	No	0	4	5
201	R:R:F232	R:R:R243	2.14	Yes	No	0	4	6
202	R:R:K234	R:R:R236	7.43	No	No	0	3	2
203	R:R:E235	R:R:L240	7.95	No	No	0	4	4
204	R:R:G239	R:R:R236	4.5	No	No	0	4	2
205	R:R:E238	R:R:I237	10.93	No	No	0	4	3
206	R:R:G239	R:R:K242	3.49	No	No	0	4	5
207	R:R:L240	R:R:R241	2.43	No	No	0	4	4
208	R:R:K242	R:R:R245	2.48	No	No	0	5	7
209	R:R:L247	R:R:R244	3.64	No	No	0	6	5
210	R:R:I249	R:R:S248	4.64	No	No	0	7	6
211	R:R:F312	R:R:I249	12.56	No	No	0	6	7
212	R:R:L253	R:R:L308	2.77	No	No	0	7	8
213	R:R:C260	R:R:V300	1.71	No	No	0	7	5
214	R:R:C260	R:R:N301	11.02	No	Yes	0	7	9
215	R:R:H265	R:R:W261	8.46	No	Yes	0	8	9
216	R:R:S298	R:R:W261	2.47	No	Yes	0	7	9
217	R:R:N301	R:R:W261	10.17	Yes	Yes	0	9	9
218	R:R:C294	R:R:P263	3.77	No	No	10	6	9
219	R:R:I297	R:R:P263	5.08	No	No	10	6	9
220	R:R:H265	R:R:Y264	5.44	No	No	0	8	6
221	R:R:K268	R:R:Y264	14.33	No	No	1	5	6
222	L:L:?1	R:R:Y264	15.19	Yes	No	1	0	6
223	R:R:F291	R:R:V267	2.62	No	No	0	4	4
224	R:R:C294	R:R:V267	1.71	No	No	0	6	4
225	L:L:?1	R:R:K268	3.05	Yes	No	1	0	5
226	R:R:M272	R:R:T269	3.01	No	No	0	5	6
227	R:R:F283	R:R:L270	2.44	Yes	No	0	3	5
228	R:R:S275	R:R:Y271	10.17	No	No	0	4	4
229	L:L:?1	R:R:Y271	8.44	Yes	No	0	0	4
230	R:R:G274	R:R:L273	3.42	No	No	0	3	4
231	R:R:H278	R:R:L277	3.86	No	No	0	2	1
232	R:R:C281	R:R:W279	3.92	No	Yes	11	8	1
233	R:R:F283	R:R:W279	9.02	Yes	Yes	0	3	1
234	R:R:D284	R:R:W279	5.58	No	Yes	11	4	1
235	R:R:D282	R:R:P280	4.83	No	No	0	2	4
236	R:R:C281	R:R:D284	4.67	No	No	11	8	4
237	R:R:D282	R:R:F283	7.17	No	Yes	0	2	3
238	R:R:F283	R:R:F286	2.14	Yes	No	0	3	1
239	R:R:F283	R:R:L287	2.44	Yes	No	0	3	4
240	R:R:D284	R:R:L287	4.07	No	No	0	4	4
241	R:R:F286	R:R:L285	2.44	No	No	0	1	3
242	R:R:L287	R:R:M288	2.83	No	No	0	4	4
243	R:R:N289	R:R:Y293	10.47	No	No	0	2	5
244	R:R:F291	R:R:P292	4.33	No	No	0	4	4
245	L:L:?1	R:R:F291	15.79	Yes	No	0	0	4
246	R:R:C294	R:R:I297	3.27	No	No	10	6	6
247	R:R:S298	R:R:T295	3.2	No	Yes	0	7	5
248	R:R:T295	R:R:Y299	7.49	Yes	Yes	1	5	7
249	L:L:?1	R:R:T295	2.12	Yes	Yes	1	0	5
250	R:R:C296	R:R:I297	3.27	No	No	0	5	6
251	R:R:C303	R:R:V300	1.71	No	No	0	7	5
252	R:R:L308	R:R:Y309	4.69	No	Yes	0	8	9
253	R:R:F312	R:R:L308	3.65	No	No	0	6	8
254	R:R:D313	R:R:Y309	5.75	No	Yes	0	8	9
255	R:R:F311	R:R:F312	11.79	No	No	0	6	6
256	R:R:D313	R:R:P314	4.83	No	No	5	8	5
257	R:R:D313	R:R:R315	15.48	No	No	5	8	7
258	R:R:P314	R:R:R315	7.21	No	No	5	5	7
259	R:R:A147	R:R:T150	1.68	No	No	0	4	6
260	R:R:M162	R:R:P163	1.68	No	No	0	4	8
261	R:R:S204	R:R:S205	1.63	No	Yes	0	4	4
262	R:R:N305	R:R:P306	1.63	No	No	0	9	9
263	R:R:A130	R:R:I131	1.62	No	No	0	8	8
264	R:R:A158	R:R:M162	1.61	No	No	0	4	4
265	R:R:V148	R:R:V152	1.6	No	No	0	3	2
266	R:R:S192	R:R:T190	1.6	No	No	0	2	1
267	R:R:V211	R:R:V212	1.6	No	No	0	4	6
268	R:R:V251	R:R:V252	1.6	No	No	0	3	5
269	R:R:V251	R:R:V255	1.6	No	No	0	3	4
270	R:R:T52	R:R:V53	1.59	No	No	0	7	6
271	R:R:T81	R:R:V80	1.59	Yes	No	0	7	4
272	R:R:C119	R:R:L153	1.59	No	No	0	7	6
273	R:R:T207	R:R:V203	1.59	No	No	0	3	4
274	R:R:T215	R:R:V211	1.59	No	No	0	2	4
275	R:R:A258	R:R:L259	1.58	No	No	0	5	5
276	R:R:I249	R:R:V252	1.54	No	No	0	7	5
277	R:R:I290	R:R:V267	1.54	No	No	0	4	4
278	R:R:M272	R:R:V203	1.52	No	No	0	5	4
279	R:R:L37	R:R:V38	1.49	No	No	0	5	7
280	R:R:L153	R:R:V152	1.49	No	No	0	6	2
281	R:R:L259	R:R:V255	1.49	No	No	0	5	4
282	R:R:L48	R:R:T52	1.47	No	No	0	5	7
283	R:R:L266	R:R:T269	1.47	No	No	0	6	6
284	R:R:D94	R:R:V179	1.46	No	No	0	4	5
285	R:R:G28	R:R:Y293	1.45	No	No	0	3	5
286	R:R:P134	R:R:R133	1.44	No	Yes	0	8	6
287	R:R:I228	R:R:L247	1.43	No	No	0	8	6
288	R:R:I250	R:R:L247	1.43	No	No	0	7	6
289	R:R:G274	R:R:W279	1.41	No	Yes	0	3	1
290	R:R:L104	R:R:L108	1.38	No	Yes	0	5	4
291	R:R:A138	R:R:R139	1.38	No	No	0	5	4
292	R:R:L304	R:R:N301	1.37	No	Yes	0	6	9
293	R:R:D184	R:R:L167	1.36	No	No	0	3	5
294	R:R:E235	R:R:K234	1.35	No	No	0	4	3
295	R:R:R55	R:R:S56	1.32	No	No	0	6	5
296	R:R:R141	R:R:S145	1.32	No	Yes	0	7	4
297	R:R:F232	R:R:L246	1.22	Yes	No	0	4	7
298	R:R:F307	R:R:L304	1.22	No	No	0	6	6
299	R:R:F257	R:R:N301	1.21	No	Yes	0	8	9
300	R:R:L277	R:R:W279	1.14	No	Yes	0	1	1
301	R:R:F232	R:R:R236	1.07	Yes	No	0	4	2
302	L:L:?1	R:R:M288	1.02	Yes	No	0	0	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I31	7.51	4	1	6
2	R:R:Y35	8.625	6	1	7
3	R:R:N46	7.675	4	4	9
4	R:R:V49	2.84	4	4	8
5	R:R:F67	4.37	4	0	7
6	R:R:F78	5.2625	4	0	6
7	R:R:T81	4.0475	4	1	7
8	R:R:L82	5.518	5	1	7
9	R:R:W85	7.3125	4	1	6
10	R:R:R91	5.9075	4	0	3
11	R:R:W95	6.41429	7	2	8
12	R:R:F97	7.9575	4	2	6
13	R:R:K103	5.785	4	0	7
14	R:R:Y107	4.59	4	7	5
15	R:R:L108	3.945	4	0	4
16	R:R:F110	7.5	4	1	5
17	R:R:V111	2.6425	4	7	4
18	R:R:N112	6.165	4	0	8
19	R:R:Y114	4.846	5	0	6
20	R:R:T121	3.22	4	0	7
21	R:R:Y128	8.4525	4	0	8
22	R:R:R133	3.9475	4	0	6
23	R:R:S145	2.6875	4	6	4
24	R:R:S205	2.3075	4	8	4
25	R:R:P213	4.0975	4	0	9
26	R:R:Y221	5.74	5	9	8
27	R:R:F232	3.348	5	0	4
28	R:R:W261	6.1475	4	0	9
29	R:R:W279	4.214	5	11	1
30	R:R:F283	4.642	5	0	3
31	R:R:T295	5.3875	4	1	5
32	R:R:Y299	5.786	5	1	7
33	R:R:N301	5.9425	4	0	9
34	R:R:Y309	7.1175	4	0	9
35	L:L:?1	8.283	10	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:V38	R:R:Y299	11.1389	3.79	No	Yes	0	7	7
2	L:L:?1	R:R:T295	20.2213	2.12	Yes	Yes	1	0	5
3	L:L:?1	R:R:W85	42.4892	13.94	Yes	Yes	1	0	6
4	R:R:T81	R:R:W85	17.0486	2.43	Yes	Yes	1	7	6
5	R:R:T81	R:R:V80	26.7479	1.59	Yes	No	0	7	4
6	R:R:L76	R:R:V80	25.2301	2.98	No	No	0	7	4
7	R:R:L76	R:R:N46	23.7466	8.24	No	Yes	0	7	9
8	R:R:N46	R:R:V49	17.6753	2.96	Yes	Yes	4	9	8
9	R:R:T52	R:R:V49	11.5795	3.17	No	Yes	0	7	8
10	R:R:F78	R:R:Y299	23.0121	6.19	Yes	Yes	0	6	7
11	R:R:F78	R:R:N112	54.6269	7.25	Yes	Yes	0	6	8
12	R:R:N112	R:R:V111	66.2701	2.96	Yes	Yes	0	8	4
13	R:R:A157	R:R:V111	100	1.7	No	Yes	0	7	4
14	R:R:A115	R:R:A157	99.4663	1.79	No	No	0	7	7
15	R:R:A115	R:R:A74	97.8065	1.79	No	No	0	7	8
16	R:R:A74	R:R:S116	97.2337	1.71	No	No	0	8	9
17	R:R:S116	R:R:V117	96.651	3.23	No	No	0	9	7
18	R:R:P213	R:R:V117	96.0586	3.53	Yes	No	0	9	7
19	R:R:P213	R:R:T121	92.2983	3.5	Yes	Yes	0	9	7
20	R:R:M217	R:R:T121	89.5956	4.52	No	Yes	0	8	7
21	R:R:M217	R:R:S124	88.8954	6.13	No	No	0	8	9
22	R:R:S124	R:R:Y221	59.4154	10.17	No	Yes	9	9	8
23	R:R:L253	R:R:Y221	44.3008	3.52	No	Yes	0	7	8
24	R:R:L253	R:R:L308	43.2139	2.77	No	No	0	7	8
25	R:R:L308	R:R:Y309	32.4765	4.69	No	Yes	0	8	9
26	R:R:I68	R:R:Y309	11.5501	14.51	No	Yes	0	8	9
27	R:R:D65	R:R:I68	10.14	2.8	No	No	0	8	8
28	R:R:F67	R:R:L123	11.0556	3.65	Yes	No	0	7	8
29	R:R:L123	R:R:Y309	16.0497	3.52	No	Yes	0	8	9
30	R:R:F125	R:R:V144	12.9113	5.24	No	No	0	6	4
31	R:R:F125	R:R:L129	14.0668	9.74	No	No	0	6	5
32	R:R:L129	R:R:Y128	15.3643	4.69	No	Yes	0	5	8
33	R:R:C220	R:R:Y128	30.9832	5.38	No	Yes	0	6	8
34	R:R:C220	R:R:S124	28.7652	5.16	No	No	9	6	9
35	R:R:F118	R:R:L153	13.8856	3.65	No	No	0	5	6
36	R:R:F118	R:R:Y114	15.5259	2.06	No	Yes	0	5	6
37	R:R:F110	R:R:Y114	22.6449	3.09	Yes	Yes	0	5	6
38	L:L:?1	R:R:F110	12.2846	11.4	Yes	Yes	1	0	5
39	R:R:M113	R:R:Y114	15.8784	5.99	No	Yes	0	7	6
40	R:R:F78	R:R:M113	26.8459	4.98	Yes	No	0	6	7
41	R:R:L108	R:R:N112	16.9164	2.75	Yes	Yes	0	4	8
42	R:R:R168	R:R:W85	38.0043	3	No	Yes	0	5	6
43	R:R:K103	R:R:R168	36.085	2.48	Yes	No	0	7	5
44	R:R:K103	R:R:T99	55.3662	3	Yes	No	0	7	3
45	R:R:G98	R:R:T99	54.2401	1.82	No	No	0	8	3
46	R:R:G98	R:R:W95	53.1042	2.81	No	Yes	0	8	8
47	R:R:P96	R:R:W95	43.5321	5.4	No	Yes	2	4	8
48	R:R:P96	R:R:R91	42.7683	11.53	No	Yes	0	4	3
49	R:R:R91	R:R:Y88	28.5497	2.06	Yes	No	0	3	5
50	R:R:Q180	R:R:Y88	24.4663	4.51	No	No	0	2	5
51	R:R:D94	R:R:R91	13.4792	3.57	No	Yes	0	4	3
52	R:R:K103	R:R:V166	25.6904	15.18	Yes	No	0	7	4
53	R:R:V111	R:R:Y107	28.4078	2.52	Yes	Yes	7	4	5
54	R:R:A161	R:R:V111	12.4951	3.39	No	Yes	7	7	4
55	R:R:A161	R:R:V164	14.0276	1.7	No	No	0	7	4
56	R:R:F110	R:R:V164	14.2382	10.49	Yes	No	0	5	4
57	R:R:M165	R:R:Y107	26.2779	8.38	No	Yes	0	5	5
58	R:R:S205	R:R:Y114	21.9301	2.54	Yes	Yes	0	4	6
59	R:R:N301	R:R:W261	19.1295	10.17	Yes	Yes	0	9	9
60	R:R:Q180	R:R:Y182	23.0856	6.76	No	No	0	2	4
61	R:R:T169	R:R:Y182	21.6951	4.99	No	No	0	4	4
62	R:R:D184	R:R:T169	20.2948	14.45	No	No	0	3	4
63	R:R:D184	R:R:L167	17.5382	1.36	No	No	0	3	5
64	R:R:L167	R:R:M183	16.1085	5.65	No	No	0	5	5
65	R:R:T207	R:R:V203	11.0899	1.59	No	No	0	3	4
66	R:R:T206	R:R:T207	12.9211	3.14	No	No	0	5	3
67	R:R:S205	R:R:T206	14.6641	3.2	Yes	No	8	4	5
68	R:R:I250	R:R:Y221	22.3365	8.46	No	Yes	0	7	8
69	R:R:F232	R:R:I228	17.1171	10.05	Yes	No	0	4	8
70	R:R:I228	R:R:L247	18.3754	1.43	No	No	0	8	6
71	R:R:I250	R:R:L247	21.0928	1.43	No	No	0	7	6
72	R:R:F232	R:R:R236	11.555	1.07	Yes	No	0	4	2
73	R:R:F312	R:R:I249	10.1204	12.56	No	No	0	6	7
74	R:R:F312	R:R:L308	12.9309	3.65	No	No	0	6	8
75	R:R:F283	R:R:L287	15.8637	2.44	Yes	No	0	3	4
76	R:R:L287	R:R:M288	27.3355	2.83	No	No	0	4	4
77	L:L:?1	R:R:M288	28.584	1.02	Yes	No	0	0	4
78	R:R:D284	R:R:L287	10.1694	4.07	No	No	0	4	4
79	R:R:L82	R:R:Y299	11.6285	3.52	Yes	Yes	1	7	7
80	L:L:?1	R:R:F78	32.736	2.63	Yes	Yes	0	0	6
81	R:R:L108	R:R:T81	16.4659	7.37	Yes	Yes	0	4	7
82	R:R:M165	R:R:V166	25.4896	7.61	No	No	0	5	4
83	R:R:M113	R:R:W261	14.6641	3.49	No	Yes	0	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:T295	R:R:Y35	8.74	1	Yes	Yes	5	7	1	2
R:R:Y299	R:R:Y35	7.94	1	Yes	Yes	7	7	2	2
R:R:F78	R:R:N112	7.25	0	Yes	Yes	6	8	1	2
R:R:F78	R:R:M113	4.98	0	Yes	No	6	7	1	2
R:R:F78	R:R:Y299	6.19	0	Yes	Yes	6	7	1	2
L:L:?1	R:R:F78	2.63	1	Yes	Yes	0	6	0	1
R:R:T81	R:R:W85	2.43	1	Yes	Yes	7	6	2	1
R:R:S105	R:R:T81	4.8	1	No	Yes	5	7	2	2
R:R:L108	R:R:T81	7.37	0	Yes	Yes	4	7	2	2
R:R:S105	R:R:W85	9.88	1	No	Yes	5	6	2	1
R:R:R168	R:R:W85	3	0	No	Yes	5	6	2	1
L:L:?1	R:R:W85	13.94	1	Yes	Yes	0	6	0	1
R:R:I109	R:R:L108	4.28	1	No	Yes	6	4	1	2
R:R:L108	R:R:N112	2.75	0	Yes	Yes	4	8	2	2
R:R:F110	R:R:I109	5.02	1	Yes	No	5	6	1	1
L:L:?1	R:R:I109	9.25	1	Yes	No	0	6	0	1
R:R:F110	R:R:Y114	3.09	1	Yes	Yes	5	6	1	2
R:R:F110	R:R:V164	10.49	1	Yes	No	5	4	1	2
L:L:?1	R:R:F110	11.4	1	Yes	Yes	0	5	0	1
R:R:M113	R:R:Y114	5.99	0	No	Yes	7	6	2	2
R:R:H265	R:R:Y264	5.44	0	No	No	8	6	2	1
R:R:K268	R:R:Y264	14.33	1	No	No	5	6	1	1
L:L:?1	R:R:Y264	15.19	1	Yes	No	0	6	0	1
R:R:F291	R:R:V267	2.62	0	No	No	4	4	1	2
L:L:?1	R:R:K268	3.05	1	Yes	No	0	5	0	1
R:R:S275	R:R:Y271	10.17	0	No	No	4	4	2	1
L:L:?1	R:R:Y271	8.44	1	Yes	No	0	4	0	1
R:R:L287	R:R:M288	2.83	0	No	No	4	4	2	1
R:R:F291	R:R:P292	4.33	0	No	No	4	4	1	2
L:L:?1	R:R:F291	15.79	1	Yes	No	0	4	0	1
R:R:S298	R:R:T295	3.2	0	No	Yes	7	5	2	1
R:R:T295	R:R:Y299	7.49	1	Yes	Yes	5	7	1	2
L:L:?1	R:R:T295	2.12	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M288	1.02	1	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7W0M_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.7
Number of Linked Nodes	268
Number of Links	302
Number of Hubs	35
Number of Links mediated by Hubs	134
Number of Communities	11
Number of Nodes involved in Communities	53
Number of Links involved in Communities	65

Path Summary
Number Of Nodes in MetaPath	84
Number Of Links MetaPath	83
Number of Shortest Paths	44719
Length Of Smallest Path	3
Average Path Length	16.1416
Length of Longest Path	40
Minimum Path Strength	1.26667
Average Path Strength	4.77876
Maximum Path Strength	18.935
Minimum Path Correlation	0.7
Average Path Correlation	0.937309
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.94118
Average % Of Corr. Nodes	50.5431
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.1122
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	8EH
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	8EH
Name	(1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide
Synonyms
Identifier
Formula	C24 H27 N7 O5 S
Molecular Weight	525.58
SMILES
PubChem	122701908
Formal Charge	0
Total Atoms	64
Total Chiral Atoms	2
Total Bonds	67
Total Aromatic Bonds	23


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35414
Sequence	>7W0M_nogp_Chain_R S S G A L I P A I Y M L V F L L G T T G N G L V L W T V F R S S R E K R R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D Y D W P F G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R P V A N A R L R L R V S G A V A T A V L W V L A A L L A M P V M V L R T T G D L E N T T K V Q C Y M D Y S M V A T V S S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R K E R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L L H W P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5VBL	A	Peptide	Apelin	Apelin	Homo sapiens	AMG3054	-	-	2.6	2017-05-31	doi.org/10.1016/j.str.2017.04.008
	6KNM	A	Peptide	Apelin	Apelin	Homo sapiens	JN241-9	-	-	3.2	2020-01-29	doi.org/10.1126/sciadv.aax7379
	7W0M	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-	Gi1/β1/γ2	3.71	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0M (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-		3.71	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0O	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-	Gi1/β1/γ2	3.78	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0O (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-		3.78	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0P	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-	Gi1/β1/γ2	3.16	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0P (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-		3.16	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7SUS	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-	-	2.7	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0L	A	Peptide	Apelin	Apelin; Apelin	Homo sapiens	PubChem 122701908	-	Gi1/β1/γ2	3.57	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0L (No Gprot)	A	Peptide	Apelin	Apelin; Apelin	Homo sapiens	PubChem 122701908	-		3.57	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0N	A	Peptide	Apelin	Apelin; Apelin	Homo sapiens	Elabela	-	Gi1/β1/γ2	4.21	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0N (No Gprot)	A	Peptide	Apelin	Apelin; Apelin	Homo sapiens	Elabela	-		4.21	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	9KUV	A	Peptide	Apelin	Apelin	Homo sapiens	CMPD644	-	Arrestin2	3.21	2025-09-17	doi.org/10.1038/s41467-025-62870-z
	9KUW	A	Peptide	Apelin	Apelin; Apelin	Homo sapiens	CMPD644	-	Arrestin2 ; Arrestin2	3.49	2025-09-17	doi.org/10.1038/s41467-025-62870-z
	9KUX	A	Peptide	Apelin	Apelin; Apelin	Homo sapiens	CMPD644	-	Arrestin2	3.57	2025-09-17	doi.org/10.1038/s41467-025-62870-z
	8XZF	A	Peptide	Apelin	Apelin; Apelin	Homo sapiens	WN561	-	Gi1/β1/γ2	3	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZF (No Gprot)	A	Peptide	Apelin	Apelin; Apelin	Homo sapiens	WN561	-		3	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZG	A	Peptide	Apelin	Apelin; Apelin	Homo sapiens	Apelin-13	-	Gi1/β1/γ2	3.2	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZG (No Gprot)	A	Peptide	Apelin	Apelin; Apelin	Homo sapiens	Apelin-13	-		3.2	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZH	A	Peptide	Apelin	Apelin; Apelin	Homo sapiens	MM07	-	Gi1/β1/γ2	2.06	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZH (No Gprot)	A	Peptide	Apelin	Apelin; Apelin	Homo sapiens	MM07	-		2.06	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZI	A	Peptide	Apelin	Apelin; Apelin	Homo sapiens	CMF-019	-	Gi1/β1/γ2	2.7	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZI (No Gprot)	A	Peptide	Apelin	Apelin; Apelin	Homo sapiens	CMF-019	-		2.7	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZJ	A	Peptide	Apelin	Apelin; Apelin	Homo sapiens	WN353	-	Gi1/β1/γ2	3	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZJ (No Gprot)	A	Peptide	Apelin	Apelin; Apelin	Homo sapiens	WN353	-		3	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8S4D	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-	-	2.58	2024-12-04	doi.org/10.1038/s41467-024-55381-w
	8XQF	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-	Gi1/β1/γ2	3.13	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQF (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-		3.13	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8Z7J	A	Peptide	Apelin	Apelin	Homo sapiens	JN241-9	-	Gi1/β1/γ2	3.12	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8Z7J (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	JN241-9	-		3.12	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQE	A	Peptide	Apelin	Apelin; Apelin	Homo sapiens	Apelin-13	-	Gi1/β1/γ2	3.48	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQE (No Gprot)	A	Peptide	Apelin	Apelin; Apelin	Homo sapiens	Apelin-13	-		3.48	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQI	A	Peptide	Apelin	Apelin; Apelin	Homo sapiens	-	-	-	3.25	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQJ	A	Peptide	Apelin	Apelin; Apelin	Homo sapiens	JN241	-	-	2.95	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8Z74	A	Peptide	Apelin	Apelin; Apelin	Homo sapiens	JN241-9	-	-	3.01	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	9JH3	A	Peptide	Apelin	Apelin; Apelin	Homo sapiens	CMF-019	-	Gi1/β1/γ2	2.93	2025-04-23	doi.org/10.1073/pnas.2423432122
	9JH3 (No Gprot)	A	Peptide	Apelin	Apelin; Apelin	Homo sapiens	CMF-019	-		2.93	2025-04-23	doi.org/10.1073/pnas.2423432122

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