psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Q1	R:R:S192	7.22	No	No	0	0	2
2	L:L:Q3	L:L:V5	4.3	No	No	0	0	0
3	L:L:Q3	L:L:S25	7.22	No	No	0	0	0
4	L:L:C22	L:L:L4	4.76	No	No	2	0	0
5	L:L:C95	L:L:L4	6.35	Yes	No	2	0	0
6	L:L:Q122	L:L:V5	12.89	No	No	0	0	0
7	L:L:E6	L:L:W36	4.36	Yes	Yes	2	0	0
8	L:L:C95	L:L:E6	7.6	Yes	Yes	2	0	0
9	L:L:E6	L:L:Q122	14.02	Yes	No	2	0	0
10	L:L:E6	L:L:G123	4.91	Yes	No	0	0	0
11	L:L:E6	L:L:T124	9.88	Yes	No	0	0	0
12	L:L:G9	L:L:V126	5.52	No	No	0	0	0
13	L:L:S11	L:L:T127	4.8	No	No	0	0	0
14	L:L:L85	L:L:V12	5.96	No	No	0	0	0
15	L:L:Q13	L:L:S129	8.66	No	No	0	0	0
16	L:L:N83	L:L:S17	4.47	No	No	0	0	0
17	L:L:T19	L:L:Y79	3.75	No	Yes	0	0	0
18	L:L:Q81	L:L:T19	8.5	No	No	0	0	0
19	L:L:L20	L:L:W36	20.5	No	Yes	2	0	0
20	L:L:L20	L:L:L80	12.46	No	Yes	2	0	0
21	L:L:L20	L:L:Y93	5.86	No	Yes	2	0	0
22	L:L:I77	L:L:S21	4.64	No	No	9	0	0
23	L:L:S21	L:L:Y79	6.36	No	Yes	9	0	0
24	L:L:C22	L:L:W36	3.92	No	Yes	2	0	0
25	L:L:C22	L:L:C95	7.28	No	Yes	2	0	0
26	L:L:S30	L:L:T28	7.99	No	Yes	0	0	0
27	L:L:S31	L:L:T28	6.4	No	Yes	0	0	0
28	L:L:N73	L:L:T28	10.24	No	Yes	0	0	0
29	L:L:T28	R:R:H278	5.48	Yes	No	0	0	2
30	L:L:M51	L:L:Y29	5.99	Yes	No	0	0	0
31	L:L:R100	L:L:Y29	6.17	No	No	0	0	0
32	L:L:Y29	R:R:L285	5.86	No	No	0	0	3
33	L:L:S30	R:R:Y271	5.09	No	Yes	0	0	4
34	L:L:S30	R:R:D284	4.42	No	No	0	0	4
35	L:L:H32	L:L:S31	8.37	No	No	10	0	0
36	L:L:S31	R:R:W195	6.18	No	Yes	10	0	2
37	L:L:H32	L:L:P99	7.63	No	No	0	0	0
38	L:L:H32	R:R:W195	4.23	No	Yes	10	0	2
39	L:L:C33	L:L:Q71	4.58	No	No	0	0	0
40	L:L:C110	L:L:C33	5.46	No	No	0	0	0
41	L:L:C33	L:L:W112	3.92	No	Yes	0	0	0
42	L:L:L78	L:L:M34	12.72	Yes	No	0	0	0
43	L:L:L78	L:L:W36	7.97	Yes	Yes	0	0	0
44	L:L:L80	L:L:W36	15.94	Yes	Yes	2	0	0
45	L:L:W36	L:L:Y93	4.82	Yes	Yes	2	0	0
46	L:L:C95	L:L:W36	7.84	Yes	Yes	2	0	0
47	L:L:F37	L:L:G47	9.03	Yes	No	0	0	0
48	L:L:F37	L:L:L50	6.09	Yes	No	0	0	0
49	L:L:F37	L:L:K115	8.69	Yes	No	11	0	0
50	L:L:F37	L:L:W120	10.02	Yes	No	11	0	0
51	L:L:R38	L:L:V48	3.92	Yes	No	0	0	0
52	L:L:A91	L:L:R38	6.91	No	Yes	2	0	0
53	L:L:R38	L:L:Y93	9.26	Yes	Yes	2	0	0
54	L:L:Q39	L:L:R45	5.84	No	No	7	0	0
55	L:L:M92	L:L:Q39	12.23	No	No	7	0	0
56	L:L:Q39	L:L:Y94	9.02	No	Yes	7	0	0
57	L:L:P41	L:L:Q125	6.32	No	No	0	0	0
58	L:L:E44	L:L:E46	8.88	No	No	0	0	0
59	L:L:R45	L:L:Y94	9.26	No	Yes	7	0	0
60	L:L:F67	L:L:V48	3.93	Yes	No	0	0	0
61	L:L:A49	L:L:Y59	8.01	No	No	12	0	0
62	L:L:A49	L:L:I69	6.5	No	No	12	0	0
63	L:L:L50	L:L:W112	19.36	No	Yes	0	0	0
64	L:L:L50	R:R:E174	6.63	No	Yes	0	0	2
65	L:L:M51	L:L:Q71	4.08	Yes	No	0	0	0
66	L:L:M51	R:R:E20	4.06	Yes	No	0	0	5
67	L:L:S58	L:L:T52	4.8	No	No	8	0	0
68	L:L:T52	R:R:E174	14.11	No	Yes	8	0	2
69	L:L:R53	L:L:Y109	14.4	Yes	Yes	5	0	0
70	L:L:R53	R:R:D23	7.15	Yes	No	0	0	5
71	L:L:R53	R:R:Y93	10.29	Yes	No	5	0	4
72	L:L:R53	R:R:M288	8.69	Yes	No	0	0	4
73	L:L:S54	L:L:Y109	8.9	No	Yes	0	0	0
74	L:L:R55	L:L:S58	13.18	No	No	8	0	0
75	L:L:R55	R:R:E174	5.82	No	Yes	8	0	2
76	L:L:S58	R:R:E174	11.5	No	Yes	8	0	2
77	L:L:I69	L:L:Y59	8.46	No	No	12	0	0
78	L:L:F67	L:L:V63	18.35	Yes	No	0	0	0
79	L:L:R66	L:L:S84	7.91	No	No	0	0	0
80	L:L:F67	L:L:L80	4.87	Yes	Yes	2	0	0
81	L:L:F67	L:L:M82	11.2	Yes	No	2	0	0
82	L:L:F67	L:L:Y93	4.13	Yes	Yes	2	0	0
83	L:L:Q81	L:L:T68	8.5	No	No	0	0	0
84	L:L:I69	L:L:L78	7.14	No	Yes	0	0	0
85	L:L:S70	L:L:Y79	5.09	No	Yes	0	0	0
86	L:L:L78	L:L:Q71	3.99	Yes	No	0	0	0
87	L:L:D72	L:L:T74	7.23	No	No	0	0	0
88	L:L:D72	L:L:K75	13.83	No	No	0	0	0
89	L:L:K75	L:L:Y79	4.78	No	Yes	0	0	0
90	L:L:I77	L:L:Y79	10.88	No	Yes	9	0	0
91	L:L:L80	L:L:M82	4.24	Yes	No	2	0	0
92	L:L:L85	L:L:V128	7.45	No	No	0	0	0
93	L:L:E88	L:L:K86	4.05	No	No	0	0	0
94	L:L:D89	L:L:K86	4.15	No	No	0	0	0
95	L:L:E88	L:L:P87	9.43	No	No	0	0	0
96	L:L:P87	L:L:S130	5.34	No	No	0	0	0
97	L:L:T90	L:L:V128	4.76	No	No	0	0	0
98	L:L:A91	L:L:Y93	4	No	Yes	2	0	0
99	L:L:M92	L:L:Y94	8.38	No	Yes	7	0	0
100	L:L:M92	L:L:Q125	4.08	No	No	0	0	0
101	L:L:V126	L:L:Y93	6.31	No	Yes	0	0	0
102	L:L:G123	L:L:Y94	10.14	No	Yes	0	0	0
103	L:L:A96	L:L:W120	3.89	No	No	0	0	0
104	L:L:V98	L:L:W112	15.94	No	Yes	0	0	0
105	L:L:K111	L:L:P99	13.38	No	No	0	0	0
106	L:L:C110	L:L:R100	6.96	No	No	0	0	0
107	L:L:R100	R:R:Y271	4.12	No	Yes	0	0	4
108	L:L:E104	L:L:G102	4.91	No	No	0	0	0
109	L:L:G102	L:L:S106	3.71	No	No	0	0	0
110	L:L:I103	R:R:Y271	12.09	No	Yes	0	0	4
111	L:L:I103	R:R:F291	11.3	No	No	0	0	4
112	L:L:E104	R:R:M183	5.41	No	No	0	0	5
113	L:L:Y105	R:R:W85	22.19	No	Yes	0	0	6
114	L:L:Y105	R:R:T295	4.99	No	No	0	0	5
115	L:L:Y105	R:R:Y299	6.95	No	Yes	0	0	7
116	L:L:A108	R:R:M288	4.83	No	No	0	0	4
117	L:L:Y109	R:R:Y93	8.94	Yes	No	5	0	4
118	L:L:Y109	R:R:L173	4.69	Yes	No	5	0	3
119	L:L:Y109	R:R:Q180	11.27	Yes	No	5	0	2
120	L:L:M114	L:L:N113	4.21	No	No	0	0	0
121	L:L:N113	R:R:L173	9.61	No	No	0	0	3
122	L:L:M114	L:L:S117	4.6	No	No	0	0	0
123	L:L:D116	L:L:K115	6.91	No	No	0	0	0
124	L:L:K115	L:L:W120	5.8	No	No	11	0	0
125	R:R:C19	R:R:C281	7.28	No	No	0	8	8
126	R:R:D23	R:R:S27	8.83	No	No	0	5	3
127	R:R:D23	R:R:N289	14.81	No	No	0	5	2
128	R:R:S26	R:R:W24	11.12	No	No	0	3	1
129	R:R:L30	R:R:S26	6.01	No	No	0	5	3
130	R:R:I31	R:R:Y35	6.04	Yes	Yes	0	6	7
131	R:R:I31	R:R:T89	4.56	Yes	No	0	6	5
132	R:R:I31	R:R:Y293	4.84	Yes	No	0	6	5
133	R:R:P32	R:R:T89	8.74	No	No	0	5	5
134	R:R:C296	R:R:I34	8.18	No	No	0	5	5
135	R:R:L82	R:R:Y35	10.55	No	Yes	4	7	7
136	R:R:A86	R:R:Y35	4	No	Yes	0	6	7
137	R:R:T295	R:R:Y35	4.99	No	Yes	0	5	7
138	R:R:C296	R:R:Y35	5.38	No	Yes	0	5	7
139	R:R:Y299	R:R:Y35	4.96	Yes	Yes	4	7	7
140	R:R:F39	R:R:M36	4.98	Yes	No	4	6	3
141	R:R:M36	R:R:P83	6.71	No	No	4	3	9
142	R:R:L37	R:R:L41	8.3	No	No	0	5	5
143	R:R:F39	R:R:L40	3.65	Yes	No	0	6	5
144	R:R:F39	R:R:T43	9.08	Yes	No	0	6	5
145	R:R:F39	R:R:P83	15.89	Yes	No	4	6	9
146	R:R:C303	R:R:L41	4.76	No	No	0	7	5
147	R:R:C303	R:R:G42	3.92	No	No	0	7	8
148	R:R:D75	R:R:N46	12.12	No	No	0	9	9
149	R:R:N46	R:R:P306	8.15	No	No	0	9	9
150	R:R:P306	R:R:V49	7.07	No	No	0	9	8
151	R:R:F316	R:R:V49	5.24	Yes	No	0	9	8
152	R:R:F54	R:R:L50	10.96	No	Yes	0	3	7
153	R:R:A72	R:R:L50	4.73	No	Yes	0	8	7
154	R:R:L50	R:R:V73	4.47	Yes	No	0	7	5
155	R:R:T52	R:R:W51	4.85	Yes	No	6	7	3
156	R:R:R55	R:R:W51	16.99	No	No	6	6	3
157	R:R:R55	R:R:T52	3.88	No	Yes	6	6	7
158	R:R:F316	R:R:T52	6.49	Yes	Yes	6	9	7
159	R:R:C320	R:R:T52	6.76	No	Yes	6	6	7
160	R:R:D65	R:R:V53	7.3	Yes	No	0	8	6
161	R:R:K60	R:R:S56	7.65	Yes	No	0	6	5
162	R:R:R58	R:R:S57	9.22	No	No	0	6	6
163	R:R:K60	R:R:R62	6.19	Yes	No	0	6	7
164	R:R:F316	R:R:K60	4.96	Yes	Yes	0	9	6
165	R:R:R315	R:R:R62	13.86	No	No	0	7	7
166	R:R:D126	R:R:S63	7.36	Yes	No	0	8	6
167	R:R:S145	R:R:S63	6.52	No	No	0	4	6
168	R:R:D65	R:R:I68	4.2	Yes	No	0	8	8
169	R:R:I66	R:R:T150	6.08	No	No	0	5	6
170	R:R:F67	R:R:G122	4.52	Yes	No	0	7	6
171	R:R:F67	R:R:L123	3.65	Yes	No	0	7	8
172	R:R:D126	R:R:F67	4.78	Yes	Yes	0	8	7
173	R:R:S70	R:R:T150	4.8	Yes	No	0	9	6
174	R:R:S70	R:R:W154	3.71	Yes	Yes	0	9	9
175	R:R:D75	R:R:L71	8.14	No	No	0	9	9
176	R:R:L120	R:R:L71	4.15	Yes	No	0	8	9
177	R:R:D75	R:R:S302	5.89	No	No	0	9	8
178	R:R:L108	R:R:T77	10.32	No	No	13	4	7
179	R:R:N112	R:R:T77	10.24	No	No	13	8	7
180	R:R:F78	R:R:I109	6.28	Yes	No	0	6	6
181	R:R:F78	R:R:N112	6.04	Yes	No	0	6	8
182	R:R:F78	R:R:M113	3.73	Yes	No	0	6	7
183	R:R:F78	R:R:Y299	7.22	Yes	Yes	0	6	7
184	R:R:S105	R:R:T81	4.8	No	No	0	5	7
185	R:R:I109	R:R:T81	4.56	No	No	0	6	7
186	R:R:L82	R:R:Y299	16.41	No	Yes	4	7	7
187	R:R:L84	R:R:W95	6.83	No	Yes	3	6	8
188	R:R:F97	R:R:L84	13.4	No	No	3	6	6
189	R:R:W85	R:R:W95	10.31	Yes	Yes	3	6	8
190	R:R:S105	R:R:W85	6.18	No	Yes	3	5	6
191	R:R:I109	R:R:W85	4.7	No	Yes	0	6	6
192	R:R:C181	R:R:W85	6.53	Yes	Yes	3	9	6
193	R:R:Y88	R:R:Y93	10.92	No	No	0	5	4
194	R:R:W95	R:R:Y88	5.79	Yes	No	0	8	5
195	R:R:P96	R:R:R91	11.53	No	No	0	4	3
196	R:R:D92	R:R:K178	6.91	No	No	0	6	2
197	R:R:D94	R:R:P96	6.44	No	No	0	4	4
198	R:R:D94	R:R:K178	15.21	No	No	0	4	2
199	R:R:D94	R:R:V179	4.38	No	No	0	4	5
200	R:R:F97	R:R:W95	7.02	No	Yes	3	6	8
201	R:R:C102	R:R:W95	6.53	Yes	Yes	3	9	8
202	R:R:S105	R:R:W95	3.71	No	Yes	3	5	8
203	R:R:C181	R:R:W95	6.53	Yes	Yes	3	9	8
204	R:R:F101	R:R:F97	16.08	No	No	0	5	6
205	R:R:T170	R:R:T99	10.99	No	No	0	5	3
206	R:R:F100	R:R:F101	8.57	No	No	0	1	5
207	R:R:C102	R:R:R168	4.18	Yes	Yes	3	9	5
208	R:R:C102	R:R:C181	7.28	Yes	Yes	3	9	9
209	R:R:K103	R:R:R168	4.95	No	Yes	0	7	5
210	R:R:R168	R:R:S106	15.81	Yes	No	0	5	5
211	R:R:V111	R:R:Y107	8.83	No	No	0	4	5
212	R:R:M165	R:R:Y107	13.17	No	No	0	5	5
213	R:R:L108	R:R:N112	4.12	No	No	13	4	8
214	R:R:F110	R:R:V164	10.49	No	No	0	5	4
215	R:R:M113	R:R:W261	5.82	No	Yes	1	7	9
216	R:R:M113	R:R:Y264	5.99	No	Yes	1	7	6
217	R:R:F118	R:R:Y114	7.22	Yes	No	0	5	6
218	R:R:L160	R:R:Y114	10.55	No	No	0	4	6
219	R:R:S205	R:R:Y114	7.63	No	No	0	4	6
220	R:R:A115	R:R:W154	7.78	No	Yes	0	7	9
221	R:R:F257	R:R:V117	5.24	Yes	No	1	8	7
222	R:R:V117	R:R:W261	3.68	No	Yes	1	7	9
223	R:R:F118	R:R:L153	3.65	Yes	No	0	5	6
224	R:R:F118	R:R:L156	3.65	Yes	No	0	5	4
225	R:R:F118	R:R:P213	5.78	Yes	No	0	5	9
226	R:R:F257	R:R:L120	3.65	Yes	Yes	1	8	8
227	R:R:L120	R:R:N305	6.87	Yes	No	1	8	9
228	R:R:L120	R:R:Y309	12.89	Yes	Yes	1	8	9
229	R:R:P213	R:R:T121	5.25	No	No	0	9	7
230	R:R:M217	R:R:T121	6.02	Yes	No	0	8	7
231	R:R:L123	R:R:R127	17.01	No	No	1	8	9
232	R:R:L123	R:R:Y309	4.69	No	Yes	1	8	9
233	R:R:M217	R:R:S124	6.13	Yes	No	1	8	9
234	R:R:S124	R:R:Y221	12.72	No	Yes	1	9	8
235	R:R:F125	R:R:L129	18.27	No	Yes	0	6	5
236	R:R:F125	R:R:R143	5.34	No	No	0	6	3
237	R:R:D126	R:R:R141	5.96	Yes	Yes	0	8	7
238	R:R:R127	R:R:Y221	8.23	No	Yes	1	9	8
239	R:R:R127	R:R:Y309	7.2	No	Yes	1	9	9
240	R:R:L129	R:R:Y128	5.86	Yes	Yes	14	5	8
241	R:R:V132	R:R:Y128	8.83	No	Yes	0	7	8
242	R:R:N137	R:R:Y128	10.47	No	Yes	14	6	8
243	R:R:C220	R:R:Y128	4.03	No	Yes	0	6	8
244	R:R:F223	R:R:Y128	8.25	Yes	Yes	0	5	8
245	R:R:L129	R:R:N137	8.24	Yes	No	14	5	6
246	R:R:L129	R:R:R141	8.5	Yes	Yes	0	5	7
247	R:R:A130	R:R:R141	4.15	No	Yes	0	8	7
248	R:R:I131	R:R:I224	5.89	No	No	0	8	8
249	R:R:T227	R:R:V132	6.35	No	No	0	4	7
250	R:R:R133	R:R:V135	7.85	No	No	0	6	6
251	R:R:N137	R:R:R133	7.23	No	No	0	6	6
252	R:R:A138	R:R:R141	5.53	No	Yes	0	5	7
253	R:R:L140	R:R:R139	4.86	No	No	0	4	4
254	R:R:R143	R:R:V144	6.54	No	No	0	3	4
255	R:R:L156	R:R:L160	6.92	No	No	0	4	4
256	R:R:L160	R:R:V208	5.96	No	No	0	4	5
257	R:R:L167	R:R:V166	4.47	No	No	0	5	4
258	R:R:L167	R:R:Y185	8.21	No	Yes	0	5	5
259	R:R:C181	R:R:R168	4.18	Yes	Yes	3	9	5
260	R:R:M183	R:R:R168	3.72	No	Yes	0	5	5
261	R:R:T169	R:R:Y182	12.48	No	No	15	4	4
262	R:R:D184	R:R:T169	5.78	No	No	15	3	4
263	R:R:D172	R:R:V179	5.84	No	No	0	1	5
264	R:R:L173	R:R:Q180	3.99	No	No	5	3	2
265	R:R:D184	R:R:Y182	8.05	No	No	15	3	4
266	R:R:M183	R:R:Y185	7.18	No	Yes	0	5	5
267	R:R:D184	R:R:M187	4.16	No	No	0	3	2
268	R:R:E194	R:R:Y185	16.83	No	Yes	0	6	5
269	R:R:W197	R:R:Y185	6.75	No	Yes	0	2	5
270	R:R:E198	R:R:Y185	5.61	No	Yes	0	4	5
271	R:R:L201	R:R:Y185	5.86	No	Yes	0	4	5
272	R:R:A189	R:R:E194	4.53	No	No	0	1	6
273	R:R:A189	R:R:W197	7.78	No	No	0	1	2
274	R:R:S193	R:R:T190	4.8	No	No	0	4	1
275	R:R:V199	R:R:W195	4.9	No	Yes	0	3	2
276	R:R:S275	R:R:W195	9.88	No	Yes	0	4	2
277	R:R:H265	R:R:T206	6.85	No	Yes	0	8	5
278	R:R:K268	R:R:T206	4.5	No	Yes	0	5	5
279	R:R:T206	R:R:T269	4.71	Yes	No	0	5	6
280	R:R:F210	R:R:F214	19.29	Yes	Yes	0	8	6
281	R:R:F210	R:R:W261	7.02	Yes	Yes	1	8	9
282	R:R:F210	R:R:M262	3.73	Yes	No	0	8	5
283	R:R:F210	R:R:H265	7.92	Yes	No	1	8	8
284	R:R:F214	R:R:L218	12.18	Yes	No	0	6	4
285	R:R:F214	R:R:F257	7.5	Yes	Yes	0	6	8
286	R:R:M217	R:R:Y221	4.79	Yes	Yes	1	8	8
287	R:R:F257	R:R:M217	9.95	Yes	Yes	1	8	8
288	R:R:L218	R:R:V254	4.47	No	No	0	4	7
289	R:R:F223	R:R:T219	5.19	Yes	No	0	5	4
290	R:R:I250	R:R:Y221	7.25	No	Yes	0	7	8
291	R:R:V254	R:R:Y221	3.79	No	Yes	0	7	8
292	R:R:F222	R:R:F223	5.36	No	Yes	0	3	5
293	R:R:I228	R:R:L246	5.71	No	No	0	8	7
294	R:R:A229	R:R:R243	4.15	No	No	0	4	6
295	R:R:F232	R:R:R236	8.55	No	No	0	4	2
296	R:R:F232	R:R:K242	6.2	No	No	0	4	5
297	R:R:F232	R:R:R243	4.28	No	No	0	4	6
298	R:R:E235	R:R:R233	8.14	No	No	0	4	4
299	R:R:K234	R:R:L240	8.46	No	No	0	3	4
300	R:R:G239	R:R:R236	7.51	No	No	0	4	2
301	R:R:F312	R:R:R245	8.55	No	No	0	6	7
302	R:R:I249	R:R:L253	4.28	No	No	0	7	7
303	R:R:F312	R:R:I249	21.35	No	No	0	6	7
304	R:R:L253	R:R:L308	4.15	No	Yes	0	7	8
305	R:R:L253	R:R:Y309	8.21	No	Yes	0	7	9
306	R:R:L304	R:R:T256	4.42	No	No	0	6	6
307	R:R:L308	R:R:T256	4.42	Yes	No	0	8	6
308	R:R:F257	R:R:W261	10.02	Yes	Yes	1	8	9
309	R:R:C260	R:R:W261	7.84	No	Yes	0	7	9
310	R:R:C260	R:R:N301	11.02	No	No	0	7	9
311	R:R:W261	R:R:Y264	5.79	Yes	Yes	1	9	6
312	R:R:H265	R:R:W261	9.52	No	Yes	1	8	9
313	R:R:S298	R:R:W261	7.41	No	Yes	1	7	9
314	R:R:C294	R:R:P263	3.77	No	No	0	6	9
315	R:R:I297	R:R:P263	5.08	No	No	0	6	9
316	R:R:K268	R:R:Y264	13.14	No	Yes	0	5	6
317	R:R:F291	R:R:Y264	9.28	No	Yes	0	4	6
318	R:R:S298	R:R:Y264	6.36	No	Yes	1	7	6
319	R:R:L287	R:R:V267	7.45	No	No	0	4	4
320	R:R:F283	R:R:L270	4.87	Yes	No	0	3	5
321	R:R:L273	R:R:L277	9.69	No	No	0	4	1
322	R:R:G274	R:R:W279	4.22	No	Yes	0	3	1
323	R:R:L277	R:R:W279	7.97	No	Yes	0	1	1
324	R:R:P280	R:R:W279	4.05	No	Yes	0	4	1
325	R:R:F283	R:R:W279	9.02	Yes	Yes	0	3	1
326	R:R:D282	R:R:P280	4.83	No	No	0	2	4
327	R:R:F283	R:R:L287	15.83	Yes	No	0	3	4
328	R:R:F286	R:R:I290	13.82	No	No	0	1	4
329	R:R:N301	R:R:N305	10.9	No	No	0	9	9
330	R:R:N305	R:R:Y309	4.65	No	Yes	1	9	9
331	R:R:F307	R:R:L308	4.87	No	Yes	0	6	8
332	R:R:F307	R:R:F311	6.43	No	No	0	6	6
333	R:R:A310	R:R:F316	8.32	No	Yes	0	6	9
334	R:R:F311	R:R:R317	10.69	No	No	0	6	8
335	R:R:D313	R:R:P314	4.83	No	No	0	8	5
336	R:R:D313	R:R:R315	8.34	No	No	0	8	7
337	R:R:P314	R:R:R317	8.65	No	No	0	5	8
338	R:R:C320	R:R:F316	5.59	No	Yes	6	6	9
339	R:R:G45	R:R:T44	3.64	No	No	0	8	4
340	R:R:L247	R:R:R243	3.64	No	No	0	6	6
341	R:R:M272	R:R:Y271	3.59	No	Yes	0	5	4
342	L:L:D89	L:L:F67	3.58	No	Yes	0	0	0
343	R:R:D284	R:R:F283	3.58	No	Yes	0	4	3
344	R:R:P134	R:R:V135	3.53	No	No	0	8	6
345	R:R:P213	R:R:V212	3.53	No	No	0	9	6
346	R:R:L285	R:R:Y21	3.52	No	No	0	3	4
347	L:L:E46	L:L:R38	3.49	No	Yes	0	0	0
348	R:R:C119	R:R:S70	3.44	No	Yes	0	7	9
349	L:L:A24	L:L:S27	3.42	No	No	0	0	0
350	L:L:A97	L:L:S27	3.42	No	No	0	0	0
351	R:R:G45	R:R:L48	3.42	No	No	0	8	5
352	R:R:A319	R:R:S56	3.42	No	No	0	5	5
353	R:R:C294	R:R:V267	3.42	No	No	0	6	4
354	L:L:A97	L:L:V2	3.39	No	No	0	0	0
355	R:R:I31	R:R:P292	3.39	Yes	No	0	6	4
356	R:R:A161	R:R:V111	3.39	No	No	0	7	4
357	R:R:A149	R:R:V144	3.39	No	No	0	5	4
358	R:R:C102	R:R:T170	3.38	Yes	No	0	9	5
359	R:R:M162	R:R:P163	3.35	No	No	0	4	8
360	R:R:L82	R:R:P83	3.28	No	No	4	7	9
361	R:R:L201	R:R:P163	3.28	No	No	0	4	8
362	L:L:S21	L:L:S7	3.26	No	No	0	0	0
363	L:L:S130	L:L:S14	3.26	No	No	0	0	0
364	L:L:S119	L:L:V2	3.23	No	No	0	0	0
365	L:L:S62	L:L:V63	3.23	No	No	0	0	0
366	L:L:A24	L:L:M34	3.22	No	No	0	0	0
367	L:L:A97	L:L:M34	3.22	No	No	0	0	0
368	L:L:A40	L:L:K43	3.21	No	No	0	0	0
369	R:R:V300	R:R:V38	3.21	No	No	0	5	7
370	L:L:S54	R:R:T176	3.2	No	No	0	0	3
371	R:R:S192	R:R:T190	3.2	No	No	0	2	1
372	R:R:C19	R:R:L285	3.17	No	No	0	8	3
373	R:R:T43	R:R:V79	3.17	No	No	0	5	6
374	R:R:T170	R:R:V179	3.17	No	No	0	5	5
375	R:R:T215	R:R:V212	3.17	No	No	0	2	6
376	R:R:A64	R:R:D126	3.09	No	Yes	0	8	8
377	R:R:I216	R:R:V212	3.07	No	No	0	6	6
378	R:R:I290	R:R:V267	3.07	No	No	0	4	4
379	R:R:F118	R:R:G209	3.01	Yes	No	0	5	5
380	R:R:K103	R:R:T169	3	No	No	0	7	4
381	R:R:L48	R:R:V49	2.98	No	No	0	5	8
382	R:R:L159	R:R:V155	2.98	No	No	0	4	4
383	R:R:L167	R:R:V188	2.98	No	No	0	5	2
384	R:R:L308	R:R:V252	2.98	Yes	No	0	8	5
385	L:L:D61	L:L:S62	2.94	No	No	0	0	0
386	R:R:G171	R:R:Y182	2.9	No	No	0	1	4
387	R:R:K103	R:R:M165	2.88	No	No	0	7	5
388	L:L:S70	R:R:E20	2.87	No	No	0	0	5
389	R:R:I228	R:R:L247	2.85	No	No	0	8	6
390	L:L:L85	L:L:M82	2.83	No	No	0	0	0
391	L:L:Q125	L:L:T127	2.83	No	No	0	0	0
392	R:R:L104	R:R:M165	2.83	No	No	0	5	5
393	L:L:G35	L:L:W112	2.81	No	Yes	0	0	0
394	R:R:G98	R:R:W95	2.81	No	Yes	0	8	8
395	R:R:P32	R:R:Y90	2.78	No	No	0	5	3
396	R:R:D65	R:R:K60	2.77	Yes	Yes	0	8	6
397	R:R:A157	R:R:F118	2.77	No	Yes	0	7	5
398	R:R:A136	R:R:R133	2.77	No	No	0	4	6
399	R:R:A136	R:R:R139	2.77	No	No	0	4	4
400	R:R:A258	R:R:F214	2.77	No	Yes	0	5	6
401	R:R:L266	R:R:L270	2.77	No	No	0	6	5
402	R:R:F67	R:R:S70	2.64	Yes	Yes	0	7	9
403	R:R:A74	R:R:W154	2.59	No	Yes	0	8	9
404	L:L:T57	L:L:Y59	2.5	No	No	0	0	0
405	R:R:V73	R:R:W154	2.45	No	Yes	0	5	9
406	R:R:L142	R:R:R143	2.43	No	No	0	6	3
407	R:R:L240	R:R:R244	2.43	No	No	0	4	5
408	R:R:L246	R:R:R245	2.43	No	No	0	7	7
409	R:R:I224	R:R:Y221	2.42	No	Yes	0	8	8
410	L:L:E104	R:R:F110	2.33	No	No	0	0	5
411	R:R:E59	R:R:R58	2.33	No	No	0	5	6
412	R:R:L276	R:R:W195	2.28	No	Yes	0	1	2
413	L:L:G8	L:L:G9	2.11	No	No	0	0	0
414	L:L:G10	L:L:G9	2.11	No	No	0	0	0
415	L:L:G15	L:L:G16	2.11	No	No	0	0	0
416	R:R:G28	R:R:P32	2.03	No	No	0	3	5
417	L:L:A101	L:L:G102	1.95	No	No	0	0	0
418	L:L:A108	L:L:G107	1.95	No	No	0	0	0
419	R:R:W24	R:R:Y293	1.93	No	No	0	1	5
420	L:L:A40	L:L:P41	1.87	No	No	0	0	0
421	L:L:G15	L:L:S84	1.86	No	No	0	0	0
422	L:L:G118	L:L:S119	1.86	No	No	0	0	0
423	R:R:G202	R:R:S205	1.86	No	No	0	5	4
424	L:L:G16	L:L:V12	1.84	No	No	0	0	0
425	L:L:G118	R:R:V191	1.84	No	No	0	0	2
426	R:R:G200	R:R:V199	1.84	No	No	0	2	3
427	L:L:G56	R:R:T22	1.82	No	No	0	0	4
428	R:R:G146	R:R:I66	1.76	No	No	0	7	5
429	L:L:G56	L:L:M51	1.75	No	Yes	0	0	0
430	L:L:G65	L:L:K64	1.74	No	No	0	0	0
431	L:L:G10	L:L:L18	1.71	No	No	0	0	0
432	L:L:A60	L:L:S62	1.71	No	No	0	0	0
433	R:R:G47	R:R:L76	1.71	No	No	0	3	7
434	R:R:A196	R:R:S193	1.71	No	No	0	1	4
435	R:R:G42	R:R:N46	1.7	No	No	0	8	9
436	R:R:A69	R:R:V53	1.7	No	No	0	5	6
437	R:R:A147	R:R:T150	1.68	No	No	0	4	6
438	L:L:E6	L:L:G121	1.64	Yes	No	2	0	0
439	L:L:G121	L:L:Q122	1.64	No	No	2	0	0
440	L:L:S11	L:L:S129	1.63	No	No	0	0	0
441	L:L:A23	L:L:I77	1.62	No	No	0	0	0
442	R:R:S116	R:R:V117	1.62	No	No	0	9	7
443	R:R:S204	R:R:T207	1.6	No	Yes	0	4	3
444	R:R:V254	R:R:V255	1.6	No	No	0	7	4
445	R:R:T81	R:R:V80	1.59	No	No	0	7	4
446	R:R:T207	R:R:V203	1.59	Yes	No	0	3	4
447	R:R:T206	R:R:V211	1.59	Yes	No	0	5	4
448	R:R:T207	R:R:V208	1.59	Yes	No	0	3	5
449	R:R:T207	R:R:V211	1.59	Yes	No	0	3	4
450	R:R:A225	R:R:L247	1.58	No	No	0	5	6
451	R:R:I34	R:R:V38	1.54	No	No	0	5	7
452	R:R:I250	R:R:V251	1.54	No	No	0	7	3
453	L:L:M114	R:R:S186	1.53	No	No	0	0	5
454	L:L:N83	L:L:S84	1.49	No	No	0	0	0
455	R:R:D65	R:R:S57	1.47	Yes	No	0	8	6
456	R:R:Q318	R:R:T321	1.42	No	No	0	6	4
457	R:R:L50	R:R:L76	1.38	Yes	No	0	7	7
458	R:R:H231	R:R:T227	1.37	No	No	0	5	4
459	R:R:A158	R:R:Y107	1.33	No	No	0	4	5
460	R:R:F223	R:R:Q226	1.17	Yes	No	0	5	3
461	R:R:Q318	R:R:R315	1.17	No	No	0	6	7
462	R:R:K25	R:R:W24	1.16	No	No	0	4	1
463	R:R:E235	R:R:R236	1.16	No	No	0	4	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:E6	7.06833	6	2	0
2	L:L:T28	7.5275	4	0	0
3	L:L:W36	9.33571	7	2	0
4	L:L:F37	8.4575	4	11	0
5	L:L:R38	5.895	4	2	0
6	L:L:M51	3.97	4	0	0
7	L:L:R53	10.1325	4	5	0
8	L:L:F67	7.67667	6	2	0
9	L:L:L78	7.955	4	0	0
10	L:L:Y79	6.172	5	9	0
11	L:L:L80	9.3775	4	2	0
12	L:L:Y93	5.73	6	2	0
13	L:L:Y94	9.2	4	7	0
14	L:L:C95	7.2675	4	2	0
15	L:L:Y109	9.64	5	5	0
16	L:L:W112	10.5075	4	0	0
17	R:R:I31	4.7075	4	0	6
18	R:R:Y35	5.98667	6	4	7
19	R:R:F39	8.4	4	4	6
20	R:R:L50	5.385	4	0	7
21	R:R:T52	5.495	4	6	7
22	R:R:K60	5.3925	4	0	6
23	R:R:D65	3.935	4	0	8
24	R:R:F67	3.8975	4	0	7
25	R:R:S70	3.6475	4	0	9
26	R:R:F78	5.8175	4	0	6
27	R:R:W85	9.982	5	3	6
28	R:R:W95	6.19125	8	3	8
29	R:R:C102	5.3425	4	3	9
30	R:R:F118	4.34667	6	0	5
31	R:R:L120	6.89	4	1	8
32	R:R:D126	5.2975	4	0	8
33	R:R:Y128	7.488	5	14	8
34	R:R:L129	10.2175	4	14	5
35	R:R:R141	6.035	4	0	7
36	R:R:W154	4.1325	4	0	9
37	R:R:R168	6.568	5	3	5
38	R:R:E174	9.515	4	8	2
39	R:R:C181	6.13	4	3	9
40	R:R:Y185	8.40667	6	0	5
41	R:R:W195	5.494	5	10	2
42	R:R:T206	4.4125	4	0	5
43	R:R:T207	1.5925	4	0	3
44	R:R:F210	9.49	4	1	8
45	R:R:F214	10.435	4	0	6
46	R:R:M217	6.7225	4	1	8
47	R:R:Y221	6.53333	6	1	8
48	R:R:F223	4.9925	4	0	5
49	R:R:F257	7.272	5	1	8
50	R:R:W261	7.1375	8	1	9
51	R:R:Y264	8.112	5	1	6
52	R:R:Y271	6.2225	4	0	4
53	R:R:W279	6.315	4	0	1
54	R:R:F283	8.325	4	0	3
55	R:R:Y299	8.885	4	4	7
56	R:R:L308	4.105	4	0	8
57	R:R:Y309	7.528	5	1	9
58	R:R:F316	6.12	5	6	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:E6	L:L:W36	20.9538	4.36	Yes	Yes	2	0	0
2	L:L:E6	L:L:G123	13.8159	4.91	Yes	No	0	0	0
3	L:L:W36	L:L:Y93	23.3031	4.82	Yes	Yes	2	0	0
4	L:L:G123	L:L:Y94	12.7699	10.14	No	Yes	0	0	0
5	L:L:L85	L:L:M82	10.5289	2.83	No	No	0	0	0
6	L:L:L80	L:L:M82	11.1798	4.24	Yes	No	2	0	0
7	L:L:L80	L:L:W36	24.3294	15.94	Yes	Yes	2	0	0
8	L:L:L78	L:L:W36	71.3699	7.97	Yes	Yes	0	0	0
9	L:L:L78	L:L:Q71	83.3652	3.99	Yes	No	0	0	0
10	L:L:M51	L:L:Q71	42.8776	4.08	Yes	No	0	0	0
11	L:L:C33	L:L:Q71	42.252	4.58	No	No	0	0	0
12	L:L:C110	L:L:C33	46.8564	5.46	No	No	0	0	0
13	L:L:C110	L:L:R100	47.1713	6.96	No	No	0	0	0
14	L:L:R100	R:R:Y271	96.5105	4.12	No	Yes	0	0	4
15	L:L:S30	R:R:Y271	21.2982	5.09	No	Yes	0	0	4
16	L:L:M51	L:L:Y29	47.9164	5.99	Yes	No	0	0	0
17	L:L:R100	L:L:Y29	49.4559	6.17	No	No	0	0	0
18	L:L:S30	R:R:D284	12.3791	4.42	No	No	0	0	4
19	L:L:F67	L:L:L80	12.209	4.87	Yes	Yes	2	0	0
20	L:L:F67	L:L:Y93	12.4916	4.13	Yes	Yes	2	0	0
21	L:L:I103	R:R:Y271	99.8847	12.09	No	Yes	0	0	4
22	L:L:I103	R:R:F291	99.9438	11.3	No	No	0	0	4
23	R:R:F291	R:R:Y264	100	9.28	No	Yes	0	4	6
24	R:R:M113	R:R:Y264	42.6021	5.99	No	Yes	1	7	6
25	R:R:F78	R:R:M113	69.1472	3.73	Yes	No	0	6	7
26	R:R:F78	R:R:I109	50.6495	6.28	Yes	No	0	6	6
27	R:R:I109	R:R:W85	48.3565	4.7	No	Yes	0	6	6
28	R:R:W85	R:R:W95	22.6563	10.31	Yes	Yes	3	6	8
29	R:R:W95	R:R:Y88	14.1702	5.79	Yes	No	0	8	5
30	R:R:Y88	R:R:Y93	13.4068	10.92	No	No	0	5	4
31	L:L:D89	L:L:K86	10.3743	4.15	No	No	0	0	0
32	L:L:D89	L:L:F67	12.4325	3.58	No	Yes	0	0	0
33	R:R:M183	R:R:R168	14.9041	3.72	No	Yes	0	5	5
34	R:R:C181	R:R:R168	23.521	4.18	Yes	Yes	3	9	5
35	R:R:C181	R:R:W85	29.5594	6.53	Yes	Yes	3	9	6
36	R:R:F78	R:R:Y299	16.9525	7.22	Yes	Yes	0	6	7
37	R:R:Y299	R:R:Y35	12.8627	4.96	Yes	Yes	4	7	7
38	R:R:W261	R:R:Y264	54.4047	5.79	Yes	Yes	1	9	6
39	R:R:F257	R:R:W261	74.9381	10.02	Yes	Yes	1	8	9
40	R:R:F257	R:R:L120	62.7685	3.65	Yes	Yes	1	8	8
41	R:R:L120	R:R:L71	22.5017	4.15	Yes	No	0	8	9
42	R:R:D75	R:R:L71	21.8465	8.14	No	No	0	9	9
43	R:R:D75	R:R:N46	20.5334	12.12	No	No	0	9	9
44	R:R:N46	R:R:P306	17.2154	8.15	No	No	0	9	9
45	R:R:P306	R:R:V49	16.5462	7.07	No	No	0	9	8
46	R:R:F316	R:R:V49	13.8525	5.24	Yes	No	0	9	8
47	R:R:L120	R:R:Y309	45.7091	12.89	Yes	Yes	1	8	9
48	R:R:L123	R:R:Y309	29.7281	4.69	No	Yes	1	8	9
49	R:R:F67	R:R:L123	30.9765	3.65	Yes	No	0	7	8
50	R:R:F67	R:R:S70	10.7539	2.64	Yes	Yes	0	7	9
51	R:R:L253	R:R:Y309	19.7841	8.21	No	Yes	0	7	9
52	R:R:D126	R:R:F67	20.2213	4.78	Yes	Yes	0	8	7
53	R:R:C102	R:R:T170	12.7784	3.38	Yes	No	0	9	5
54	R:R:F257	R:R:M217	14.1843	9.95	Yes	Yes	1	8	8
55	R:R:M217	R:R:T121	10.3644	6.02	Yes	No	0	8	7
56	R:R:D126	R:R:R141	17.5725	5.96	Yes	Yes	0	8	7
57	R:R:L129	R:R:R141	15.5565	8.5	Yes	Yes	0	5	7
58	R:R:I249	R:R:L253	11.2347	4.28	No	No	0	7	7
59	R:R:F312	R:R:I249	10.5022	21.35	No	No	0	6	7
60	R:R:D284	R:R:F283	11.6733	3.58	No	Yes	0	4	3
61	R:R:M113	R:R:W261	26.9753	5.82	No	Yes	1	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Q1	R:R:S192	7.22	0	No	No	0	2	0	1
L:L:T28	R:R:H278	5.48	0	Yes	No	0	2	0	1
L:L:Y29	R:R:L285	5.86	0	No	No	0	3	0	1
L:L:S30	R:R:Y271	5.09	0	No	Yes	0	4	0	1
L:L:S30	R:R:D284	4.42	0	No	No	0	4	0	1
L:L:S31	R:R:W195	6.18	10	No	Yes	0	2	0	1
L:L:H32	R:R:W195	4.23	10	No	Yes	0	2	0	1
L:L:L50	R:R:E174	6.63	0	No	Yes	0	2	0	1
L:L:M51	R:R:E20	4.06	0	Yes	No	0	5	0	1
L:L:T52	R:R:E174	14.11	8	No	Yes	0	2	0	1
L:L:R53	R:R:D23	7.15	5	Yes	No	0	5	0	1
L:L:R53	R:R:Y93	10.29	5	Yes	No	0	4	0	1
L:L:R53	R:R:M288	8.69	5	Yes	No	0	4	0	1
L:L:R55	R:R:E174	5.82	8	No	Yes	0	2	0	1
L:L:S58	R:R:E174	11.5	8	No	Yes	0	2	0	1
L:L:R100	R:R:Y271	4.12	0	No	Yes	0	4	0	1
L:L:I103	R:R:Y271	12.09	0	No	Yes	0	4	0	1
L:L:I103	R:R:F291	11.3	0	No	No	0	4	0	1
L:L:E104	R:R:M183	5.41	0	No	No	0	5	0	1
L:L:Y105	R:R:W85	22.19	0	No	Yes	0	6	0	1
L:L:Y105	R:R:T295	4.99	0	No	No	0	5	0	1
L:L:Y105	R:R:Y299	6.95	0	No	Yes	0	7	0	1
L:L:A108	R:R:M288	4.83	0	No	No	0	4	0	1
L:L:Y109	R:R:Y93	8.94	5	Yes	No	0	4	0	1
L:L:Y109	R:R:L173	4.69	5	Yes	No	0	3	0	1
L:L:Y109	R:R:Q180	11.27	5	Yes	No	0	2	0	1
L:L:N113	R:R:L173	9.61	0	No	No	0	3	0	1
R:R:D23	R:R:S27	8.83	0	No	No	5	3	1	2
R:R:D23	R:R:N289	14.81	0	No	No	5	2	1	2
R:R:L82	R:R:Y35	10.55	4	No	Yes	7	7	2	2
R:R:T295	R:R:Y35	4.99	0	No	Yes	5	7	1	2
R:R:Y299	R:R:Y35	4.96	4	Yes	Yes	7	7	1	2
R:R:F78	R:R:I109	6.28	0	Yes	No	6	6	2	2
R:R:F78	R:R:Y299	7.22	0	Yes	Yes	6	7	2	1
R:R:L82	R:R:Y299	16.41	4	No	Yes	7	7	2	1
R:R:W85	R:R:W95	10.31	3	Yes	Yes	6	8	1	2
R:R:S105	R:R:W85	6.18	3	No	Yes	5	6	2	1
R:R:I109	R:R:W85	4.7	0	No	Yes	6	6	2	1
R:R:C181	R:R:W85	6.53	3	Yes	Yes	9	6	2	1
R:R:Y88	R:R:Y93	10.92	0	No	No	5	4	2	1
R:R:W95	R:R:Y88	5.79	3	Yes	No	8	5	2	2
R:R:S105	R:R:W95	3.71	3	No	Yes	5	8	2	2
R:R:C181	R:R:W95	6.53	3	Yes	Yes	9	8	2	2
R:R:F110	R:R:V164	10.49	0	No	No	5	4	1	2
R:R:C181	R:R:R168	4.18	3	Yes	Yes	9	5	2	2
R:R:M183	R:R:R168	3.72	0	No	Yes	5	5	1	2
R:R:L173	R:R:Q180	3.99	5	No	No	3	2	1	1
R:R:M183	R:R:Y185	7.18	0	No	Yes	5	5	1	2
R:R:V199	R:R:W195	4.9	0	No	Yes	3	2	2	1
R:R:S275	R:R:W195	9.88	0	No	Yes	4	2	2	1
R:R:F291	R:R:Y264	9.28	0	No	Yes	4	6	1	2
R:R:M272	R:R:Y271	3.59	0	No	Yes	5	4	2	1
R:R:D284	R:R:F283	3.58	0	No	Yes	4	3	1	2
R:R:L285	R:R:Y21	3.52	0	No	No	3	4	1	2
L:L:S54	R:R:T176	3.2	0	No	No	0	3	0	1
R:R:S192	R:R:T190	3.2	0	No	No	2	1	1	2
R:R:C19	R:R:L285	3.17	0	No	No	8	3	2	1
L:L:S70	R:R:E20	2.87	0	No	No	0	5	0	1
L:L:E104	R:R:F110	2.33	0	No	No	0	5	0	1
R:R:L276	R:R:W195	2.28	0	No	Yes	1	2	2	1
L:L:G118	R:R:V191	1.84	0	No	No	0	2	0	1
L:L:G56	R:R:T22	1.82	0	No	No	0	4	0	1
L:L:M114	R:R:S186	1.53	0	No	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8Z7J_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.65
Number of Linked Nodes	415
Number of Links	463
Number of Hubs	58
Number of Links mediated by Hubs	227
Number of Communities	15
Number of Nodes involved in Communities	83
Number of Links involved in Communities	107

Path Summary
Number Of Nodes in MetaPath	62
Number Of Links MetaPath	61
Number of Shortest Paths	128500
Length Of Smallest Path	3
Average Path Length	16.8949
Length of Longest Path	35
Minimum Path Strength	1.295
Average Path Strength	6.70476
Maximum Path Strength	17.65
Minimum Path Correlation	0.7
Average Path Correlation	0.951403
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	56.0431
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.7789
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35414
Sequence	>8Z7J_nogp_Chain_R C E Y T D W K S S G A L I P A I Y M L V F L L G T T G N G L V L W T V F R S S R E K R R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D Y D W P F G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R P V A N A R L R L R V S G A V A T A V L W V L A A L L A M P V M V L R T T G D L E N T T K V Q C Y M D Y S M V A T V S S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R K E R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L L H W P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R F R Q A C T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XZF	A	Peptide	Apelin	Apelin	Homo sapiens	WN561	-	Gi1/β1/γ2	3	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZF (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	WN561	-		3	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZG	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-	Gi1/β1/γ2	3.2	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZG (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-		3.2	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZH	A	Peptide	Apelin	Apelin	Homo sapiens	MM07	-	Gi1/β1/γ2	2.06	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZH (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	MM07	-		2.06	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZJ	A	Peptide	Apelin	Apelin	Homo sapiens	WN353	-	Gi1/β1/γ2	3	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZJ (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	WN353	-		3	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	5VBL	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin mimetic peptide agonist	-	-	2.6	2017-05-31	doi.org/10.1016/j.str.2017.04.008
	8Z74	A	Peptide	Apelin	Apelin	Homo sapiens	Agonistic antibody	-	-	3.01	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8Z7J	A	Peptide	Apelin	Apelin	Homo sapiens	Agonistic antibody	-	Gi1/β1/γ2	3.12	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8Z7J (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Agonistic antibody	-		3.12	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	7SUS	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-	-	2.7	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0L	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-	Gi1/β1/γ2	3.57	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0L (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-		3.57	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0M	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-	Gi1/β1/γ2	3.71	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0M (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	PubChem 122701908	-		3.71	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0N	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-	Gi1/β1/γ2	4.21	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0N (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-		4.21	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0O	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-	Gi1/β1/γ2	3.78	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0O (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-		3.78	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0P	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-	Gi1/β1/γ2	3.16	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	7W0P (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Elabela	-		3.16	2022-07-27	doi.org/10.1038/s41594-022-00797-5
	6KNM	A	Peptide	Apelin	Apelin	Homo sapiens	JN241-9	-	-	3.2	2020-01-29	doi.org/10.1126/sciadv.aax7379
	8XZI	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-	Gi1/β1/γ2	2.7	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8XZI (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-		2.7	2024-03-20	doi.org/10.1016/j.cell.2024.02.004
	8S4D	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-	-	2.58	2024-12-04	doi.org/10.1038/s41467-024-55381-w
	8XQE	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-	Gi1/β1/γ2	3.48	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQE (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-		3.48	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQF	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-	Gi1/β1/γ2	3.13	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQF (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	Apelin-13	-		3.13	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQI	A	Peptide	Apelin	Apelin	Homo sapiens	-	-	-	3.25	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	8XQJ	A	Peptide	Apelin	Apelin	Homo sapiens	JN241	-	-	2.95	2025-01-22	doi.org/10.1038/s41467-024-55555-6
	9JH3	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-	Gi1/β1/γ2	2.93	2025-04-23	doi.org/10.1073/pnas.2423432122
	9JH3 (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-		2.93	2025-04-23	doi.org/10.1073/pnas.2423432122

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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