Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:P8 1.844280
2L:L:N15 5.945490
3L:L:F17 5.21590
4L:L:F18 7.815490
5L:L:Q27 8.11490
6L:L:T39 4.3975470
7L:L:K51 4.3125470
8L:L:N52 11.94254150
9L:L:C59 5.8854310
10L:L:F74 5.0225400
11L:L:V76 8.255400
12L:L:N78 12.49754210
13L:L:H79 9.5725490
14L:L:T86 8.6125450
15L:L:Y88 6.236550
16L:L:Y89 6.1675400
17L:L:H90 7.1025400
18L:L:K91 6.4375400
19N:N:C2 2.9125170
20N:N:Y7 8.66754140
21N:N:M9 4.735140
22N:N:E12 8.365300
23N:N:R13 4.9145110
24N:N:E15 8.145110
25N:N:L20 3.76400
26N:N:T24 4.04254140
27N:N:I26 6.1425400
28N:N:C27 3.73754170
29N:N:K39 4.2400
30N:N:L42 3.3675400
31N:N:K44 6.545400
32N:N:Q49 6.974310
33N:N:Y54 5.92667600
34N:N:F57 6.86400
35N:N:Y59 8.264150
36N:N:R60 7.5854140
37N:N:I64 4.0225400
38N:N:P73 4.814320
39N:N:Y77 7.4856140
40N:N:V79 3.11754140
41N:N:Y92 7.5685150
42N:N:T102 4.2825470
43R:R:H32 4.405455
44R:R:R38 5.06454
45R:R:T40 5.1458
46R:R:I44 4.2854255
47R:R:P48 3.334349
48R:R:L50 3.594345
49R:R:K58 7.7175455
50R:R:L59 3.518506
51R:R:I60 5.2575454
52R:R:T62 5.88754257
53R:R:L64 5.344256
54R:R:I67 3.4325405
55R:R:H70 5.27254224
56R:R:F72 5.3675409
57R:R:R80 7.42667654
58R:R:Y82 9.32554
59R:R:D86 5.95254258
60R:R:Q91 4.21254363
61R:R:Y98 7.0645222
62R:R:H105 9.755657
63R:R:I106 4.39407
64R:R:E107 7.3825456
65R:R:R109 8.432505
66R:R:D118 6.61405
67R:R:F130 6.938556
68R:R:F134 11.0675405
69R:R:N135 5.2175478
70R:R:T136 4.08667649
71R:R:F141 6.84407
72R:R:P142 6.2275409
73R:R:F154 6.034546
74R:R:L156 4.932547
75R:R:E157 8.04408
76R:R:I158 4.394547
77R:R:D160 5.882578
78R:R:N161 7.3825448
79R:R:N170 8.83754238
80R:R:F172 5.65833648
81R:R:L175 6.38447
82R:R:N187 7.38449
83R:R:F189 9.422548
84R:R:Y195 6.48254234
85R:R:N198 8.198336237
86R:R:Y206 4.9754126
87R:R:N208 7.0254125
88R:R:K209 5.552507
89R:R:F221 4.791676399
90R:R:L231 3.095407
91R:R:D232 9.4954129
92R:R:V238 4.2875447
93R:R:L241 3.37409
94R:R:P242 4.2765399
95R:R:L246 5.36254397
96R:R:I253 7.91754124
97R:R:F269 6.895407
98R:R:D276 7.1125124
99R:R:F286 5.306508
100R:R:L296 5.42494
101R:R:T399 3.06404
102R:R:E409 6.2875409
103R:R:I411 5.22508
104R:R:L417 5.484419
105R:R:W422 5.1275409
106R:R:L429 2.28407
107R:R:F434 4.24754247
108R:R:V435 3.3275409
109R:R:I438 6.5054248
110R:R:L439 4.96408
111R:R:Y444 8.5175407
112R:R:R450 4.906676429
113R:R:N455 7.47754188
114R:R:L456 4.655409
115R:R:D460 5.575409
116R:R:V473 4.61408
117R:R:Y481 5.282508
118R:R:W488 6.4865449
119R:R:T501 5.2354439
120R:R:E506 4.408508
121R:R:Y510 5.22754187
122R:R:T511 4.8154189
123R:R:W520 4.45507
124R:R:Y521 6.19406
125R:R:Y563 8.4325199
126R:R:I568 4.946509
127R:R:P571 4.6354199
128R:R:D573 6.74254458
129R:R:Y582 6.74254199
130R:R:I583 2.572507
131R:R:F594 4.4725408
132R:R:Y601 6.16409
133R:R:Y643 7.98408
134R:R:K660 3.9225409
135R:R:V664 3.865409
136R:R:Y667 5.20754439
137R:R:N674 6.895409
138R:R:F685 5.7065249
139A:A:L45 4.6125408
140A:A:N50 7.22754139
141A:A:T55 3.18409
142A:A:F219 6.8875408
143A:A:F222 11.95254467
144A:A:Q227 5.512519
145A:A:K233 5.798519
146A:A:W234 4.494519
147A:A:I244 3.26408
148A:A:D249 6.16754138
149A:A:S251 3.3754139
150A:A:D252 6.66254138
151A:A:Y253 8.4425408
152A:A:R265 8.3154139
153A:A:W281 9.964515
154A:A:I288 6.0275409
155A:A:L289 3.96409
156A:A:F290 4.864269
157A:A:L291 4.125488
158A:A:K293 64139
159A:A:V301 3.3425407
160A:A:F315 11.5075406
161A:A:Y318 9.7025406
162A:A:P328 4.058501
163A:A:D331 6.78754274
164A:A:V334 3.755274
165A:A:R342 7.01484
166A:A:F345 7.52408
167A:A:I348 3.9925404
168A:A:Y360 6.7185478
169A:A:F363 6.432585
170A:A:D368 4.39254269
171A:A:F376 5.268577168
172A:A:R380 5.19754167
173A:A:Y391 5.18404
174A:A:L394 4.91408
175B:B:I18 5.055407
176B:B:D27 5.75754488
177B:B:L30 3.99405
178B:B:I37 4.50254202
179B:B:V40 5.3654203
180B:B:M45 4.954524
181B:B:H54 9.658529
182B:B:K57 6.564519
183B:B:I58 3.9725429
184B:B:Y59 8.7475418
185B:B:W63 6.81833627
186B:B:R68 11.555425
187B:B:L69 5.6775425
188B:B:S72 5.305429
189B:B:Q75 8.835419
190B:B:D76 7.4875409
191B:B:K78 3.95408
192B:B:I80 8.7275428
193B:B:I81 4.6175427
194B:B:W82 8.02629
195B:B:D83 7.765428
196B:B:Y85 12.1225424
197B:B:K89 5.834529
198B:B:I93 5.134107
199B:B:L95 5.39754108
200B:B:W99 9.584509
201B:B:Y105 4.208506
202B:B:I123 4.2654496
203B:B:Y124 5.203336106
204B:B:H142 7.52833619
205B:B:Y145 5.51571718
206B:B:C149 3.84418
207B:B:F151 3.726509
208B:B:I157 3.898517
209B:B:T159 4.69833619
210B:B:D163 8.35419
211B:B:W169 6.69333618
212B:B:Q176 5.785414
213B:B:F180 7.07567
214B:B:H183 9.79833669
215B:B:D186 4.91419
216B:B:V187 4.592569
217B:B:V200 5.354536
218B:B:D205 7.015469
219B:B:K209 10.9825466
220B:B:L210 4.4825405
221B:B:W211 8.70333668
222B:B:D212 10.96754509
223B:B:Q220 5.1675437
224B:B:F222 5.862538
225B:B:H225 9.32833639
226B:B:D228 8.4675419
227B:B:I232 4.274538
228B:B:F234 5.845435
229B:B:F235 5.092506
230B:B:F241 5.99143736
231B:B:T243 5.27538
232B:B:D247 8.204539
233B:B:T249 8.655436
234B:B:R251 9.30143738
235B:B:F253 4.81636
236B:B:D254 4.544509
237B:B:R256 7.5475409
238B:B:D258 7.5625437
239B:B:L261 4.1575405
240B:B:Y264 4.954515
241B:B:I269 4.35414
242B:B:F278 5.598507
243B:B:R283 8.344209
244B:B:Y289 7.67571717
245B:B:D290 5.73667616
246B:B:N295 7.505416
247B:B:V296 3.972505
248B:B:W297 4.9725418
249B:B:D298 7.724209
250B:B:L300 6.1354206
251B:B:R304 4.055415
252B:B:G306 2.5325404
253B:B:L308 5.34427
254B:B:H311 9.99754539
255B:B:R314 12.136518
256B:B:T321 6.2475427
257B:B:M325 5.272525
258B:B:T329 4.48408
259B:B:W332 8.12667619
260B:B:L336 4.0775427
261B:B:W339 5.375629
262B:B:N340 6.402529
263G:G:L19 4.148509
264G:G:R27 4.042508
265G:G:D48 6.438336529
266G:G:P60 7.58429
267G:G:F61 5.59857728
268H:H:?1 29.78254150
269H:H:?3 11.09717210
270H:H:?6 9.845350
271H:H:?7 15.08254230
272H:H:?8 17.49254380
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:E107 R:R:H105 11.6119.85YesYes567
2R:R:E107 R:R:R109 31.20434.65YesYes065
3N:N:I96 R:R:R109 13.7516.26NoYes005
4L:L:T54 N:N:I96 13.61823.04NoNo000
5L:L:T54 L:L:Y37 13.80618.74NoNo000
6L:L:K91 R:R:R109 12.29823.71YesYes005
7L:L:H90 L:L:K91 11.053511.79YesYes000
8L:L:Y89 N:N:K39 16.73164.78YesYes000
9N:N:D35 N:N:K39 10.15984.15NoYes000
10R:R:L230 R:R:Y206 14.65994.69NoYes046
11L:L:Y37 N:N:I26 11.8664.84NoYes000
12R:R:N110 R:R:R109 56.63017.23NoYes065
13R:R:N110 R:R:N135 56.7465.45NoYes068
14L:L:L48 R:R:N135 90.86834.12NoYes008
15L:L:L48 R:R:P162 90.98123.28NoNo007
16R:R:E107 R:R:Y82 10.171911.22YesYes564
17R:R:T159 R:R:Y185 11.945411.24NoNo057
18R:R:D160 R:R:N186 14.37435.39YesNo087
19R:R:K209 R:R:N186 14.24415.6YesNo077
20R:R:K42 R:R:T40 14.8673NoYes028
21R:R:D43 R:R:K42 14.60222.77NoNo042
22R:R:D43 R:R:H63 14.33757.56NoNo044
23R:R:H63 R:R:T88 13.80792.74NoNo044
24R:R:R65 R:R:T88 13.54315.17NoNo044
25R:R:Q90 R:R:R65 13.278214.02NoNo044
26R:R:Q90 R:R:Q91 12.74842.56NoYes043
27R:R:K58 R:R:T40 15.59547.51YesYes558
28R:R:P162 R:R:Y163 91.09416.95NoNo074
29R:R:G137 R:R:Y163 91.20692.9NoNo084
30R:R:G137 R:R:T136 91.31973.64NoYes089
31R:R:N161 R:R:T136 47.29335.85YesYes489
32R:R:I158 R:R:N161 46.96374.25YesYes478
33R:R:I158 R:R:L156 47.12658.56YesYes477
34R:R:I133 R:R:T136 46.87243.04NoYes089
35R:R:I133 R:R:P142 46.92243.39NoYes089
36R:R:F141 R:R:P142 46.867111.56YesYes079
37R:R:F141 R:R:F172 47.56544.29YesYes078
38R:R:F172 R:R:L156 50.59563.65YesYes487
39R:R:F172 R:R:F197 99.19764.29YesNo089
40R:R:F197 R:R:F221 99.31137.5NoYes099
41R:R:F221 R:R:P228 49.60857.22YesNo098
42R:R:L249 R:R:P228 49.63013.28NoNo088
43R:R:F269 R:R:L249 99.5153.65YesNo078
44R:R:F221 R:R:L246 49.6084.87YesYes3997
45R:R:L246 R:R:L249 49.90088.3YesNo078
46R:R:F269 R:R:F286 1006.43YesYes078
47R:R:A285 R:R:F286 99.86575.55NoYes088
48R:R:A285 R:R:Y482 99.84885.34NoNo088
49R:R:N483 R:R:Y482 99.79799.3NoNo088
50R:R:E480 R:R:N483 99.76383.94NoNo068
51R:R:E480 R:R:H484 99.72978.62NoNo066
52R:R:H484 R:R:T477 99.71258.21NoNo069
53R:R:I411 R:R:T477 99.67823.04YesNo089
54R:R:I411 R:R:I470 98.38772.94YesNo088
55R:R:I470 R:R:I568 98.36962.94NoYes089
56R:R:I568 R:R:L570 97.14828.56YesNo099
57R:R:L570 R:R:T501 96.39032.95NoYes099
58R:R:M463 R:R:T501 96.29393.01NoYes4399
59R:R:M463 R:R:S671 96.79824.6NoNo099
60R:R:D460 R:R:S671 96.73544.42YesNo099
61R:R:D460 R:R:N674 92.9526.73YesYes099
62R:R:N674 R:R:Y678 91.64985.81YesNo099
63R:R:R519 R:R:Y678 91.49924.12NoNo099
64A:A:Y391 R:R:R519 91.144111.32YesNo049
65A:A:I245 A:A:I288 19.62755.89NoYes079
66A:A:D378 A:A:I288 21.16511.2NoYes079
67A:A:D378 A:A:Y360 22.863111.49NoYes078
68A:A:Y358 A:A:Y360 11.64122.98NoYes048
69A:A:R385 A:A:Y358 11.70999.26NoNo054
70A:A:L394 A:A:R385 23.48614.86YesNo085
71A:A:L394 R:R:I622 90.3124.28YesNo088
72A:A:L393 R:R:I622 90.39122.85NoNo088
73A:A:L393 A:A:Y391 90.41763.52NoYes084
74A:A:D381 A:A:Y360 11.64128.05NoYes088
75A:A:D381 A:A:R385 11.70997.15NoNo085
76A:A:F238 B:B:W99 28.913110.02NoYes099
77A:A:F238 A:A:L44 28.960119.49NoNo099
78A:A:I244 A:A:L44 28.99595.71YesNo089
79A:A:I244 A:A:I285 79.71772.94YesNo087
80A:A:I285 A:A:T284 79.75364.56NoNo074
81A:A:R356 A:A:T284 79.78949.06NoNo024
82A:A:R356 A:A:R389 79.89676.4NoNo024
83A:A:L394 A:A:R389 79.93244.86YesNo084
84B:B:H54 B:B:I58 11.10525.3YesYes299
85B:B:I58 B:B:S316 25.48263.1YesNo099
86B:B:S316 B:B:W332 25.72094.94NoYes099
87B:B:K57 B:B:W332 12.65699.28YesYes199
88B:B:K57 B:B:Q75 12.79345.42YesYes199
89B:B:Q75 B:B:W99 25.55528.76YesYes099
90B:B:W332 B:B:Y59 12.6577.72YesYes198
91B:B:Q75 B:B:Y59 12.681313.53YesYes198
92B:B:R68 B:B:Y85 15.153524.69YesYes254
93B:B:L70 B:B:W63 10.396612.53NoYes257
94B:B:L70 B:B:W82 11.10976.83NoYes259
95A:A:I245 A:A:L45 16.78624.28NoYes078
96A:A:K53 A:A:S51 14.55824.59NoNo099
97A:A:K53 A:A:L45 15.68782.82NoYes098
98A:A:K293 A:A:N292 13.99272.8YesNo099
99A:A:N292 A:A:V247 14.13414.43NoNo097
100A:A:S51 A:A:V247 14.27554.85NoNo097
101A:A:K233 A:A:Q236 10.30862.71YesNo198
102A:A:N279 A:A:W281 50.51665.65NoYes085
103A:A:L282 A:A:N279 50.5566.87NoNo098
104A:A:I276 A:A:L282 50.59612.85NoNo089
105A:A:I276 A:A:V287 50.63641.54NoNo086
106A:A:I244 A:A:V287 50.67691.54YesNo086
107A:A:L297 A:A:S251 11.01673NoYes089
108A:A:K293 A:A:S251 11.13813.06YesYes1399
109A:A:W281 B:B:D290 44.51766.7YesYes156
110B:B:F222 B:B:F253 17.88093.22YesYes386
111B:B:F253 B:B:H225 24.71445.66YesYes369
112B:B:H225 B:B:S245 38.371911.16YesNo399
113B:B:G244 B:B:S245 38.98861.86NoNo059
114B:B:G244 B:B:I273 39.17323.53NoNo056
115B:B:I273 B:B:Y289 42.73919.67NoYes067
116B:B:C271 B:B:Y289 43.38984.03NoYes157
117B:B:C271 B:B:D290 46.98113.11NoYes156
118B:B:G306 B:B:V307 10.35361.84YesNo043
119B:B:I81 B:B:Y105 10.86866.04YesYes076
120B:B:I81 B:B:L69 12.5394.28YesYes275
121B:B:L69 B:B:R68 12.91064.86YesYes255
122B:B:C148 B:B:L190 15.73364.76NoNo065
123B:B:L190 B:B:S160 16.78233NoNo056
124B:B:S160 B:B:V187 17.8313.23NoYes069
125B:B:H183 B:B:V187 12.58519.69YesYes699
126B:B:C218 G:G:Q18 26.56366.1NoNo059
127B:B:M217 G:G:Q18 27.26052.72NoNo039
128B:B:E215 B:B:M217 27.95732.71NoNo033
129B:B:D212 B:B:E215 28.304518.19YesNo5093
130B:B:D212 B:B:L198 30.74325.43YesNo093
131B:B:L198 B:B:L210 31.09134.15NoYes035
132B:B:L210 B:B:V200 18.77692.98YesYes056
133B:B:H225 B:B:T243 13.2596.85YesYes398
134B:B:C218 B:B:W211 17.47675.22NoYes658
135B:B:F241 B:B:V200 12.65493.93YesYes366
136B:B:C148 B:B:R150 14.68494.18NoNo066
137B:B:L192 B:B:V158 10.48982.98NoNo055
138B:B:L192 B:B:R150 12.58742.43NoNo056
139R:R:N208 R:R:Y206 10.09023.49YesYes1256
140R:R:D160 R:R:T159 12.932711.56YesNo085
141R:R:D160 R:R:N135 30.63535.39YesYes788
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:F17 R:R:M300 7.46 9 Yes No 0 3 0 1
L:L:F17 R:R:D386 5.97 9 Yes No 0 5 0 1
L:L:F18 R:R:L296 6.09 9 Yes Yes 0 4 0 1
L:L:F18 R:R:M300 6.22 9 Yes No 0 3 0 1
H:H:?3 L:L:A23 5.66 21 Yes No 0 0 1 0
H:H:?3 L:L:P24 10.31 21 Yes No 0 0 1 0
H:H:?3 L:L:I25 5.12 21 Yes No 0 0 1 0
H:H:?3 L:L:L26 8.69 21 Yes No 0 0 1 0
L:L:T46 R:R:I85 3.04 0 No No 0 6 0 1
L:L:T46 R:R:V87 3.17 0 No No 0 4 0 1
L:L:L48 R:R:N135 4.12 0 No Yes 0 8 0 1
L:L:L48 R:R:P162 3.28 0 No No 0 7 0 1
L:L:V49 R:R:N135 5.91 7 No Yes 0 8 0 1
L:L:V49 R:R:D160 2.92 7 No Yes 0 8 0 1
L:L:K51 R:R:D160 4.15 7 Yes Yes 0 8 0 1
H:H:?1 L:L:N52 34.5 15 Yes Yes 0 0 1 0
L:L:R67 R:R:I152 12.53 0 No No 0 3 0 1
L:L:R67 R:R:F153 3.21 0 No No 0 5 0 1
H:H:?3 L:L:V68 8.02 21 Yes No 0 0 1 0
L:L:F74 R:R:L296 3.65 0 Yes Yes 0 4 0 1
H:H:?3 L:L:N78 33.27 21 Yes Yes 0 0 1 0
H:H:?3 L:L:T80 6.61 21 Yes No 0 0 1 0
L:L:T86 R:R:R80 5.17 5 Yes Yes 0 4 0 1
L:L:T86 R:R:H105 4.11 5 Yes Yes 0 7 0 1
L:L:Y88 R:R:H105 7.62 5 Yes Yes 0 7 0 1
L:L:Y88 R:R:F130 7.22 5 Yes Yes 0 6 0 1
L:L:Y88 R:R:I155 3.63 5 Yes No 0 5 0 1
L:L:K91 R:R:R109 3.71 0 Yes Yes 0 5 0 1
L:L:K91 R:R:E157 5.4 0 Yes Yes 0 8 0 1
H:H:?4 N:N:N23 33.27 0 No No 0 0 1 0
N:N:M32 R:R:F381 7.46 0 No No 0 4 0 1
N:N:R34 R:R:Y385 5.14 0 No No 0 4 0 1
N:N:K39 R:R:F153 4.96 0 Yes No 0 5 0 1
N:N:F41 R:R:L296 4.87 0 No Yes 0 4 0 1
N:N:F41 R:R:E297 7 0 No No 0 5 0 1
N:N:L42 R:R:E297 3.98 0 Yes No 0 5 0 1
N:N:L42 R:R:I389 2.85 0 Yes No 0 4 0 1
N:N:P43 R:R:E251 4.72 0 No No 0 5 0 1
N:N:K44 R:R:D203 11.06 0 Yes No 0 6 0 1
N:N:K44 R:R:A204 6.42 0 Yes No 0 5 0 1
N:N:K44 R:R:S229 3.06 0 Yes No 0 5 0 1
N:N:K44 R:R:L230 5.64 0 Yes No 0 4 0 1
N:N:Y45 R:R:I253 6.04 12 No Yes 0 4 0 1
N:N:Y45 R:R:R274 3.09 12 No No 0 3 0 1
N:N:Y45 R:R:D276 3.45 12 No Yes 0 4 0 1
H:H:?1 N:N:Y59 16.83 15 Yes Yes 0 0 1 0
H:H:?2 N:N:Y59 4.21 15 No Yes 0 0 1 0
N:N:D91 R:R:K209 6.91 0 No Yes 0 7 0 1
H:H:?1 N:N:Y92 3.16 15 Yes Yes 0 0 1 0
N:N:I96 R:R:R109 6.26 0 No Yes 0 5 0 1
N:N:E98 R:R:K58 9.45 5 No Yes 0 5 0 1
N:N:E98 R:R:Y82 7.86 5 No Yes 0 4 0 1
N:N:E98 R:R:E107 3.81 5 No Yes 0 6 0 1
N:N:I100 R:R:I60 5.89 0 No Yes 0 4 0 1
N:N:T102 R:R:E61 5.64 7 Yes No 0 5 0 1
R:R:K58 R:R:T40 7.51 5 Yes Yes 5 8 1 2
R:R:I60 R:R:T40 3.04 5 Yes Yes 4 8 1 2
R:R:R80 R:R:T56 6.47 5 Yes No 4 5 1 2
R:R:I60 R:R:K58 4.36 5 Yes Yes 4 5 1 1
R:R:K58 R:R:Y82 9.55 5 Yes Yes 5 4 1 1
R:R:I60 R:R:S84 7.74 5 Yes No 4 7 1 2
R:R:E61 R:R:I85 5.47 0 No No 5 6 1 1
R:R:R80 R:R:S79 5.27 5 Yes No 4 7 1 2
R:R:R80 R:R:Y82 9.26 5 Yes Yes 4 4 1 1
R:R:H105 R:R:R80 15.8 5 Yes Yes 7 4 1 1
R:R:H105 R:R:Y82 8.71 5 Yes Yes 7 4 1 1
R:R:E107 R:R:Y82 11.22 5 Yes Yes 6 4 1 1
R:R:I85 R:R:S84 6.19 0 No No 6 7 1 2
R:R:E107 R:R:H105 9.85 5 Yes Yes 6 7 1 1
R:R:F130 R:R:H105 12.44 5 Yes Yes 6 7 1 1
R:R:E107 R:R:R109 4.65 5 Yes Yes 6 5 1 1
R:R:N110 R:R:R109 7.23 0 No Yes 6 5 2 1
R:R:F134 R:R:R109 20.31 0 Yes Yes 5 5 2 1
R:R:N110 R:R:N135 5.45 0 No Yes 6 8 2 1
R:R:F130 R:R:G132 3.01 5 Yes No 6 5 1 2
R:R:F130 R:R:I155 5.02 5 Yes No 6 5 1 1
R:R:E157 R:R:F130 7 0 Yes Yes 8 6 1 1
R:R:F134 R:R:G132 4.52 0 Yes No 5 5 2 2
R:R:E157 R:R:F134 11.66 0 Yes Yes 8 5 1 2
R:R:F134 R:R:T159 7.78 0 Yes No 5 5 2 2
R:R:D160 R:R:N135 5.39 7 Yes Yes 8 8 1 1
R:R:D151 R:R:F153 3.58 0 No No 4 5 2 1
R:R:E178 R:R:I152 6.83 38 No No 5 3 2 1
R:R:E157 R:R:K183 8.1 0 Yes No 8 6 1 2
R:R:D160 R:R:T159 11.56 7 Yes No 8 5 1 2
R:R:D160 R:R:N186 5.39 7 Yes No 8 7 1 2
R:R:P162 R:R:Y163 6.95 0 No No 7 4 1 2
R:R:D203 R:R:T179 4.34 0 No No 6 5 1 2
R:R:D203 R:R:T181 2.89 0 No No 6 7 1 2
R:R:K183 R:R:Y206 5.97 0 No Yes 6 6 2 2
R:R:K209 R:R:N186 5.6 0 Yes No 7 7 1 2
R:R:N208 R:R:Y206 3.49 12 Yes Yes 5 6 2 2
R:R:L230 R:R:Y206 4.69 0 No Yes 4 6 1 2
R:R:D232 R:R:Y206 5.75 12 Yes Yes 9 6 2 2
R:R:K209 R:R:N208 8.39 0 Yes Yes 7 5 1 2
R:R:D232 R:R:N208 8.08 12 Yes Yes 9 5 2 2
R:R:K209 R:R:Q235 5.42 0 Yes No 7 4 1 2
R:R:E251 R:R:L230 7.95 0 No No 5 4 1 1
R:R:D232 R:R:S234 7.36 12 Yes No 9 9 2 2
R:R:D232 R:R:I253 16.79 12 Yes Yes 9 4 2 1
R:R:I253 R:R:S234 4.64 12 Yes No 4 9 1 2
R:R:R255 R:R:S234 3.95 0 No No 4 9 2 2
R:R:E251 R:R:R274 9.3 0 No No 5 3 1 1
R:R:D276 R:R:I253 4.2 12 Yes Yes 4 4 1 1
R:R:D276 R:R:R255 17.87 12 Yes No 4 4 1 2
R:R:D276 R:R:R274 7.15 12 Yes No 4 3 1 1
R:R:D276 R:R:T399 2.89 12 Yes Yes 4 4 1 2
R:R:E297 R:R:R293 4.65 0 No No 5 4 1 2
R:R:C390 R:R:R293 5.57 0 No No 9 4 2 2
R:R:L296 R:R:M300 7.07 9 Yes No 4 3 1 1
R:R:C390 R:R:I389 3.27 0 No No 9 4 2 1
H:H:?1 H:H:?2 64.64 15 Yes No 0 0 1 1
R:R:R112 R:R:V87 2.62 0 No No 6 4 2 1
R:R:R80 R:R:T104 2.59 5 Yes No 4 5 1 2
N:N:A46 R:R:T388 1.68 0 No No 0 4 0 1
N:N:A46 R:R:I389 1.62 0 No No 0 4 0 1
R:R:K250 R:R:S229 1.53 0 No No 7 5 2 1
N:N:F41 R:R:G294 1.51 0 No No 0 5 0 1
R:R:K209 R:R:K211 1.44 0 Yes No 7 3 1 2
L:L:M29 R:R:D382 1.39 0 No No 0 4 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
80.00Single7UTZTR14027UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
60.00Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
50.00Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
28.57Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
25.00Single5L7DCholesterol5L7D-SMO-Cholesterol
25.00Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
20.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
20.00Single6D35Cholesterol6D35-SMO-Cholesterol
20.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
20.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
20.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
20.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
20.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
20.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
20.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
20.00Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
20.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
20.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
20.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
20.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
20.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
20.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
20.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
20.00Single7DTTCa7DTT-CaS-Ca-Ca
20.00Single7DTTCa7DTT-CaS-Ca-Ca
20.00Single7DTUTryptophan7DTU-CaS-Tryptophan
20.00Single7DTUTryptophan7DTU-CaS-Tryptophan
20.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
20.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
20.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
20.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
20.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
20.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
20.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
20.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
20.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
20.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
20.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
20.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
20.00Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
20.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
20.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
20.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
20.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
20.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
20.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
20.00Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
20.00Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
20.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
20.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
20.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
20.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
20.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
20.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
20.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
20.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
20.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
20.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
20.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
20.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
20.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
20.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
20.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
20.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
20.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
20.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
20.00Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
20.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
20.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
20.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
20.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
20.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
20.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
20.00Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
20.00Single7XW7K1-707XW7-TSH-K1-70
20.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
20.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
20.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
20.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
20.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
20.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
20.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
20.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
20.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
20.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
20.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
20.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
20.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
20.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
20.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
20.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
20.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
20.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
20.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
20.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
20.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
20.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
20.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
20.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
20.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
20.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
20.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
20.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
20.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
20.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
20.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
20.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
20.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
20.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
20.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
20.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
20.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
20.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
20.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
20.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
20.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
20.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
20.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
20.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
20.00Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
20.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
20.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
20.00Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
20.00Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
20.00Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
20.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8WVXNorrin8WVX-LGR4-Norrin
20.00Single8WVYNorrin8WVY-LGR4-Norrin
20.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
20.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
20.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
20.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
20.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
20.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
20.00Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
20.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
20.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
20.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
20.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
20.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
20.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
20.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
20.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
20.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
20.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
20.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
20.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
20.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
20.00Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
20.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
20.00Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
20.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
20.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
20.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
20.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
20.00Single9KHHNorrin9KHH-LGR4-Norrin
20.00Single9S37NB219S37-LGR4-NB21
20.00Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
16.67Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
16.67Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
16.67Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
16.67Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
16.67Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.67Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.67Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
16.67Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
16.67Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
16.67Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
16.67Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
16.67Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
14.29Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
12.50Single4XT3Fractalkine4XT3-US28-Fractalkine
12.50Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
12.50Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
11.11Single8HS2Fab0468HS2-GPR20-Fab046
11.11Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
11.11Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
10.53Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
10.00Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
10.00Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
10.00Consensusp2y_offOrthosteric Ligandp2y1_off
9.09Single4XNWMRS25004XNW-P2Y1-MRS2500
9.09Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
9.09Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
9.09Single8JPSCCL78JPS-ACKR1-CCL7
9.09Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
9.09Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
8.33Single4O9RCyclopamine4O9R-SMO-Cyclopamine
8.33Single6LI0C176LI0-GPR52-C17
8.33Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
8.33Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
8.33Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
8.33Single9B9Y7DY9B9Y-CB1-7DY
8.33Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.69Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
7.69Single4BWBNeurotensin4BWB-NTS1-Neurotensin
7.69Single4QINSAG1.54QIN-SMO-SAG1.5
7.69Single5U09Taranabant5U09-CB1-Taranabant
7.69Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
7.69Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
7.69Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
7.69Single7BR3Elagolix7BR3-GnRH1-Elagolix
7.69Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
7.69Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
7.69Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
7.69Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
7.69Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
7.69Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
7.69Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
7.69Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
7.69Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
7.69Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
7.69Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
7.69Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
7.69Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
7.69Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
7.69Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
7.14Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
7.14Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
7.14Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
7.14Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
7.14Single7VV6C48/807VV6-MRGPRX2-C48/80
7.14Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
7.14Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
7.14Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9BA0A1AKN9BA0-CB1-A1AKN
7.14Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
7.14Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
7.14Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
7.14Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
7.14Consensusgrh_offOrthosteric Ligandgnrh1_off
7.14Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
7.14Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
6.90Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
6.67Single4QIMANTA XV4QIM-SMO-ANTA XV
6.67Single5T04Neurotensin5T04-NTS1-Neurotensin
6.67Single5TGZAM65385TGZ-CB1-AM6538
6.67Single6D27CAY104716D27-DP2-CAY10471
6.67Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
6.67Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
6.67Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
6.67Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
6.67Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
6.67Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
6.67Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
6.67Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
6.67Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
6.67Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
6.67Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
6.67Single7YXAONO-54306087YXA-S1P5-ONO-5430608
6.67Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
6.67Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
6.67Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
6.67Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
6.67Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
6.67Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
6.25Single4JKVTaladegib4JKV-SMO-Taladegib
6.25Single5C1MBU725C1M-μ-BU72
6.25Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
6.25Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
6.25Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
6.25Single7C4SS1P7C4S-S1P3-S1P
6.25Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
6.25Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
6.25Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
6.25Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
6.25Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
6.25Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
6.25Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
6.25Single9B9ZA1AKO9B9Z-CB1-A1AKO
6.25Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
6.25Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
6.25Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
6.25Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
6.25Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
6.25Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
5.88Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
5.88Single4BV0Neurotensin4BV0-NTS1-Neurotensin
5.88Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
5.88Single5V56TC1145V56-SMO-TC114
5.88Single5V57TC1145V57-SMO-TC114
5.88Single6OS1TRV0266OS1-AT1-TRV026
5.88Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
5.88Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
5.88Single7F1TMIP-1a7F1T-CCR5-MIP-1a
5.88Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
5.88Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
5.88Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
5.88Single7R0CAVP7R0C-V2-AVP-Arrestin2
5.88Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
5.88Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
5.88Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
5.88Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
5.88Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
5.88Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
5.88Single8E0GBU728E0G-μ-BU72
5.88Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
5.88Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
5.88Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
5.88Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
5.88Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
5.88Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
5.88Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
5.88Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
5.88Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
5.88Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
5.88Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
5.88Consensuslpa_onOrthosteric Ligandlpa1_on
5.88Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
5.88Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Consensusneurotensin_onOrthosteric Ligandnts1_on
5.88Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
5.88Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
5.88Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
5.88Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
5.56Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
5.56Single4XEENeurotensin4XEE-NTS1-Neurotensin
5.56Single4XESNeurotensin4XES-NTS1-Neurotensin
5.56Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
5.56Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
5.56Single6OS2TRV0266OS2-AT1-TRV026
5.56Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
5.56Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
5.56Single6YVRNTS8-136YVR-NTS1-NTS8-13
5.56Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
5.56Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
5.56Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
5.56Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
5.56Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
5.56Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
5.56Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
5.56Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
5.56Single8XQJJN2418XQJ-Apelin-JN241
5.56Single8XWACXCL18XWA-CXCR2-CXCL1
5.56Single8XWMCXCL68XWM-CXCR2-CXCL6
5.56Single8XWSCXCL58XWS-CXCR2-CXCL5
5.56Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
5.56Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
5.56Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
5.56Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
5.56Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
5.56Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
5.56Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
5.56Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
5.56Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
5.56Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
5.56Consensuslpa_offOrthosteric Ligandlpa1_off
5.56Consensuslpl_offOrthosteric Ligands1p_off lpa_off
5.56Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
5.56Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
5.56Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
5.56Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
5.56Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
5.56Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
5.56Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
5.26Single4BUONeurotensin4BUO-NTS1-Neurotensin
5.26Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
5.26Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
5.26Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
5.26Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
5.26Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
5.26Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
5.26Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
5.26Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
5.26Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
5.26Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
5.26Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
5.26Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
5.26Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
5.26Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
5.26Single8XVUCXCL28XVU-CXCR2-CXCL2
5.26Single8XWFCXCL38XWF-CXCR2-CXCL3
5.26Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
5.26Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
5.26Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
5.26Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
5.26Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
5.26Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
5.26Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
5.26Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
5.26Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
5.00Single6KNMJN241-96KNM-Apelin-JN241-9
5.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
5.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
5.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
5.00Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
5.00Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
5.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
5.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
5.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
5.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single8QJ2pN1628QJ2-MC4-pN162-Gs
5.00Single8XQJJN2418XQJ-Apelin-JN241
5.00Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
5.00Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
5.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
5.00Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
5.00Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
5.00Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
4.76Single4XT1Fractalkine4XT1-US28-Fractalkine
4.76Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
4.76Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
4.76Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
4.76Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
4.76Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
4.76Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
4.76Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
4.76Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
4.76Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
4.76Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
4.76Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
4.76Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
4.76Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
4.76Single8XWNCXCL88XWN-CXCR2-CXCL8
4.76Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
4.76Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
4.76Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
4.76Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
4.76Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
4.76Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
4.76Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
4.76Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
4.76Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
4.76Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
4.76Consensuslpl_onOrthosteric Ligands1p_on lpa_on
4.76Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
4.76Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
4.76Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
4.55Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
4.55Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
4.55Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
4.55Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
4.55Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
4.55Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
4.55Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
4.55Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
4.55Single7SK5CXCL127SK5-ACKR3-CXCL12
4.55Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
4.55Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
4.55Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
4.55Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.55Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
4.55Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
4.55Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
4.55Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
4.55Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
4.55Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
4.55Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
4.35Single3OE0CVX153OE0-CXCR4-CVX15
4.35Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
4.35Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.35Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
4.35Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
4.35Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
4.35Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
4.35Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
4.35Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
4.35Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
4.35Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
4.35Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
4.35Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
4.35Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
4.35Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
4.35Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
4.35Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.35Consensusangiotensin_onOrthosteric Ligandat1_on
4.35Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
4.35Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.35Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
4.35Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
4.35Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
4.35Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
4.35Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
4.35Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
4.35Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
4.35Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.35Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.17Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
4.17Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
4.17Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.17Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
4.17Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
4.17Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
4.17Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
4.17Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
4.17Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
4.17Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
4.17Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
4.17Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
4.17Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
4.17Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
4.17Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
4.17Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
4.17Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
4.17Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
4.17Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
4.17Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
4.17Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
4.17Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.17Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
4.17Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
4.17Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
4.17Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
4.17Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
4.17Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
4.17Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
4.17Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
4.17Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
4.17Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
4.17Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
4.17Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
4.17Consensusvasop-oxy_onOrthosteric Ligandv2_on
4.17Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
4.00Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
4.00Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
4.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
4.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
4.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
4.00Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
4.00Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
4.00Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
4.00Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
4.00Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
4.00Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.00Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
4.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
4.00Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
4.00Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
4.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
4.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
4.00Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
4.00Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.00Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.00Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
4.00Consensuscalcitonin_onOrthosteric Ligandctlike_on
4.00Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
4.00Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
4.00Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
4.00Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
4.00Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
4.00Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
4.00Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
4.00Consensuspac_onOrthosteric Ligandpac1_on
4.00Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
4.00Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
3.85Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
3.85Single6FJ3PTH6FJ3-PTH1-PTH
3.85Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
3.85Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
3.85Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
3.85Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
3.85Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
3.85Single7SK3CXCL127SK3-ACKR3-CXCL12
3.85Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
3.85Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
3.85Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
3.85Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
3.85Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
3.85Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
3.85Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
3.85Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
3.85Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
3.85Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
3.85Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
3.85Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
3.85Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
3.85Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
3.85Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
3.85Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
3.85Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.85Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
3.85Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
3.85Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
3.85Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
3.85Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
3.85Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
3.85Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
3.85Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
3.85Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
3.85Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
3.70Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
3.70Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
3.70Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
3.70Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
3.70Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
3.70Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
3.70Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
3.70Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
3.70Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
3.70Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
3.70Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
3.70Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
3.70Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
3.70Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
3.70Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
3.70Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3
3.70Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
3.70Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
3.70Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
3.70Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
3.70Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
3.70Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
3.70Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
3.70Consensusglp_onOrthosteric Ligandglp1_on glp2_on
3.70Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
3.70Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
3.70Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
3.70Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
3.70Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
3.70Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
3.57Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
3.57Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
3.57Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
3.57Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
3.57Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
3.57Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
3.57Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
3.57Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
3.57Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
3.57Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
3.57Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
3.57Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
3.57Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
3.57Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
3.57Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
3.57Single8IY6Endothelin-18IY6-ETB-Endothelin-1
3.57Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
3.57Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
3.57Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
3.57Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
3.57Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
3.57Consensusbradykinin_onOrthosteric Ligandbk2_on
3.57Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
3.57Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.57Consensusendothelin_onOrthosteric Ligandetb_on eta_on
3.57Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
3.57Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
3.57Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
3.57Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
3.57Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
3.57Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
3.57Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
3.45Single5GLHEndothelin-15GLH-ETB-Endothelin-1
3.45Single6IGKEndothelin-36IGK-ETB-Endothelin-3
3.45Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
3.45Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
3.45Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
3.45Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
3.45Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
3.45Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
3.45Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
3.45Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
3.45Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
3.45Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
3.45Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
3.33Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
3.33Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
3.33Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
3.33Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
3.33Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
3.33Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
3.33Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
3.33Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
3.33Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
3.33Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
3.33Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
3.23Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
3.23Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
3.23Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
3.23Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
3.23Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
3.23Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
3.23Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.23Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
3.23Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
3.23Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
3.12Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
3.12Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
3.12Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
3.12Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
3.12Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
3.12Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
3.12Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
3.12Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.12Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
3.12Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
3.12Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
3.03Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.03Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
3.03Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
3.03Consensuspth_onOrthosteric Ligandpth1_on pth2_on
2.94Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
2.94Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
2.94Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
2.86Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
2.86Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
2.86Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
2.78Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
2.70Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
2.70Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
2.56Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
2.50Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1

PDB Summary
PDB 7T9I
Class A
SubFamily Protein
Type Glycoprotein Hormone
SubType TSH
Species Homo Sapiens
Ligand TSH
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 2.9
Date 2022-08-03
D.O.I. doi.org/10.1038/s41586-022-05159-1
Net Summary
Imin 2.85
Number of Linked Nodes 1361
Number of Links 1661
Number of Hubs 272
Number of Links mediated by Hubs 966
Number of Communities 54
Number of Nodes involved in Communities 357
Number of Links involved in Communities 492
Path Summary
Number Of Nodes in MetaPath 142
Number Of Links MetaPath 141
Number of Shortest Paths 9542776
Length Of Smallest Path 3
Average Path Length 56.3471
Length of Longest Path 105
Minimum Path Strength 1.36
Average Path Strength 5.50104
Maximum Path Strength 49.57
Minimum Path Correlation 0.7
Average Path Correlation 0.999313
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.85185
Average % Of Corr. Nodes 52.6864
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 41.7999
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?3 H:H:?4 H:H:?5 H:H:?6 H:H:?7 H:H:?8
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetylglucosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP16473
Sequence
>7T9I_Chain_R
TMGCSSPPC ECHQEEDFR VTCKDIQRI PSLPPSTQT LKLIETHLR 
TIPSHAFSN LPNISRIYV SIDVTLQQL ESHSFYNLS KVTHIEIRN 
TRNLTYIDP DALKELPLL KFLGIFNTG LKMFPDLTK VYSTDIFFI 
LEITDNPYM TSIPVNAFQ GLCNETLTL KLYNNGFTS VQGYAFNGT 
KLDAVYLNK NKYLTVIDK DAFGGVYSG PSLLDVSQT SVTALPSKG 
LEHLKELIA RNTWTLKKL PLSLSFLHL TRADLSYPS HCCAFKNQK 
KIRGILESL MCNESSAFD SHYDYTICG DSEDMVCTP KSDEFNPCE 
DIMGYKFLR IVVWFVSLL ALLGNVFVL LILLTSHYK LNVPRFLMC 
NLAFADFCM GMYLLLIAS VDLYTHSEY YNHAIDWQT GPGCNTAGF 
FTVFASELS VYTLTVITL ERWYAITFA MRLDRKIRL RHACAIMVG 
GWVCCFLLA LLPLVGISS YAKVSICLP MDTETPLAL AYIVFVLTL 
NIVAFVIVC CCYVKIYIT VRNDTKIAK RMAVLIFTD FICMAPISF 
YALSAILNK PLITVSNSK ILLVLFYPL NSCANPFLY AIFTKAFQR 
DVFILLSKF GI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7T9I_Chain_A
NEEKAQREA NKKIEKQLQ KDKQVYRAT HRLLLLGAD NSGKSTIVK 
QMRGIFETK FQVDKVNFH MFDVGGQRD ERRKWIQCF NDVTAIIFV 
VDSSDYNRL QEALNLFKS IWNNRWLRT ISVILFLNK QDLLAEKVL 
AGKSKLEDY FPEFARYTT PPGEDPRVT RAKYFIRDE FLRISTASG 
DGRHYCYPH FTCAVDTEN ARRIFNDCR DIIQRMHLR QYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7T9I_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7T9I_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XW6AProteinGlycoprotein HormoneTSHHomo sapiensM22 FabML109Gs/β1/γ22.782022-08-17doi.org/10.1038/s41586-022-05173-3
7XW6 (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensM22 FabML1092.782022-08-17doi.org/10.1038/s41586-022-05173-3
7XW5AProteinGlycoprotein HormoneTSHHomo sapiensTSHML109Gs/β1/γ22.962022-08-24doi.org/10.1038/s41586-022-05173-3
7XW5 (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensTSHML1092.962022-08-24doi.org/10.1038/s41586-022-05173-3
7T9NAProteinGlycoprotein HormoneTSHHomo sapiensM22 FabDPPCGs/β1/γ22.92022-08-03doi.org/10.1038/s41586-022-05159-1
7T9N (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensM22 FabDPPC2.92022-08-03doi.org/10.1038/s41586-022-05159-1
7UTZAProteinGlycoprotein HormoneTSHHomo sapiensTR1402DPPCGs/β1/γ22.42022-08-03doi.org/10.1038/s41586-022-05159-1
7UTZ (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensTR1402DPPC2.42022-08-03doi.org/10.1038/s41586-022-05159-1
7T9MAProteinGlycoprotein HormoneTSHHomo sapiens-CS-17 Antibody-3.12022-08-10doi.org/10.1038/s41586-022-05159-1
7T9IAProteinGlycoprotein HormoneTSHHomo sapiensTSH-Gs/β1/γ22.92022-08-03doi.org/10.1038/s41586-022-05159-1
7T9I (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensTSH-2.92022-08-03doi.org/10.1038/s41586-022-05159-1
7XW7AProteinGlycoprotein HormoneTSHHomo sapiensK1-70--5.52022-08-17doi.org/10.1038/s41586-022-05173-3




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