Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Q19 10.24434
2A:A:N23 9.1325437
3A:A:Y37 9.1525404
4A:A:E50 7.4075469
5A:A:K53 7.47143759
6A:A:I56 4.3825457
7A:A:K88 7.616555
8A:A:I95 4.8675467
9A:A:K100 6.86754124
10A:A:I106 4.43254197
11A:A:R127 11.23403
12A:A:F140 8.951676123
13A:A:F142 8.591676124
14A:A:F146 8.4825124
15A:A:Y147 6.7645123
16A:A:H149 9.41405
17A:A:W154 13.6275409
18A:A:Y163 6.85404
19A:A:Y169 6.5985196
20A:A:L171 5.084198
21A:A:Y177 10.958569
22A:A:F178 7.918567
23A:A:K181 8.785464
24A:A:Y190 5.582569
25A:A:P192 5.74569
26A:A:D196 8.09569
27A:A:L197 7.1525407
28A:A:F208 4.064555
29A:A:F219 8.175408
30A:A:H220 12.725427
31A:A:M221 4.67408
32A:A:F222 14.9125427
33A:A:Q227 6.3375429
34A:A:K233 6.32333629
35A:A:W234 5.615629
36A:A:C237 6.7725428
37A:A:F238 9.526529
38A:A:Q267 5.205404
39A:A:F273 5.746676149
40A:A:W277 10.075146
41A:A:W281 13.55625
42A:A:I288 6.055409
43A:A:F290 6.116509
44A:A:N292 4.964559
45A:A:K293 4.8875409
46A:A:Q294 7.79476
47A:A:F312 4.8685208
48A:A:E314 5.5565206
49A:A:F315 9.985406
50A:A:P321 5.78575
51A:A:E330 8.1625473
52A:A:D331 5.05404
53A:A:K338 11.84475
54A:A:Y339 8.37673
55A:A:F340 10.6565207
56A:A:R342 7.874574
57A:A:E344 6.7245205
58A:A:F345 8.98408
59A:A:S349 4.7925407
60A:A:Y358 7.612504
61A:A:Y360 10.5525408
62A:A:F363 13.13475
63A:A:N371 6.7175459
64A:A:R374 12.668554
65A:A:F376 6.665178
66A:A:R385 9.6565245
67A:A:H387 10.614188
68A:A:Y391 7.59754184
69B:B:L4 4.54404
70B:B:V40 6.78754133
71B:B:I43 4.5454133
72B:B:R48 5.81487
73B:B:H54 8.58833639
74B:B:K57 10.906529
75B:B:Y59 10.102528
76B:B:M61 4.595436
77B:B:W63 6.46637
78B:B:V71 4.12254158
79B:B:Q75 11.485429
80B:B:D76 8.6025439
81B:B:K78 6.115408
82B:B:L79 74157
83B:B:W82 9.57714739
84B:B:D83 10.9525438
85B:B:T86 8.2725436
86B:B:N88 10.2075437
87B:B:K89 6.01639
88B:B:I93 4.9375407
89B:B:L95 5.1285158
90B:B:W99 9.75667629
91B:B:M101 5.502529
92B:B:Y105 4.3256156
93B:B:Y111 8.1454214
94B:B:V112 4.2154158
95B:B:L117 4.842529
96B:B:I123 3.8775406
97B:B:Y124 5.184506
98B:B:L126 3.77254155
99B:B:E130 6.795403
100B:B:H142 9.494529
101B:B:Y145 7.78728
102B:B:F151 5.812509
103B:B:I157 5.41407
104B:B:T159 6.3925429
105B:B:D163 10.0675429
106B:B:C166 4.164108
107B:B:W169 8.16857728
108B:B:F180 8.4185107
109B:B:H183 9.685109
110B:B:V187 4.0865109
111B:B:F199 9.75754109
112B:B:V200 7.2975446
113B:B:S201 5.26254109
114B:B:C204 6.18427
115B:B:D205 7.334109
116B:B:K209 11.19754106
117B:B:L210 4.624505
118B:B:W211 9.9945108
119B:B:Q220 7.3125447
120B:B:F222 8.8975448
121B:B:H225 9.23857749
122B:B:D228 8.44529
123B:B:I232 5.475448
124B:B:F234 6.4275405
125B:B:F235 8.996676166
126B:B:P236 9.22754167
127B:B:N237 9.784165
128B:B:F241 7.156546
129B:B:D246 7.55429
130B:B:D247 7.566549
131B:B:T249 6.5675446
132B:B:R251 9.99333648
133B:B:F253 7.866546
134B:B:D258 9.642547
135B:B:Q259 4.9925406
136B:B:E260 7.3475446
137B:B:M262 7.7425404
138B:B:T263 4.2875441
139B:B:Y264 8.83505
140B:B:I269 3.906524
141B:B:F278 7.0954167
142B:B:R283 7.256139
143B:B:L284 5.565135
144B:B:L285 5.49406
145B:B:Y289 7.74714727
146B:B:D290 7.7925426
147B:B:C294 5.0245115
148B:B:N295 8.562526
149B:B:L300 6.34754136
150B:B:K301 7.22405
151B:B:V307 3.7925403
152B:B:H311 10.165119
153B:B:R314 16.68528
154B:B:T321 6.9775437
155B:B:M325 6.4625405
156B:B:T329 6.45754118
157B:B:W332 11.0914729
158B:B:K337 10.33254116
159B:B:W339 10.58754119
160G:G:A23 2.735408
161G:G:R27 7.28548
162G:G:Y40 12.314166
163G:G:D48 6.956509
164G:G:L51 4.04506
165G:G:V54 4.9375486
166G:G:N59 7.33667689
167G:G:P60 6.7075489
168G:G:F61 5.27125888
169R:R:W33 14.138513
170R:R:V36 6.64412
171R:R:Q37 7.4625414
172R:R:W39 4.98857715
173R:R:Y42 10.284516
174R:R:P56 9.924271
175R:R:D67 6.93419
176R:R:Y69 7.03833616
177R:R:W72 8.58125819
178R:R:D74 10.94273
179R:R:C85 3.635409
180R:R:P86 8.418518
181R:R:Y88 8.47333615
182R:R:L89 8.086515
183R:R:P90 5.8275414
184R:R:H99 3.0925404
185R:R:R102 13.192518
186R:R:F103 6.925404
187R:R:W120 3.5625405
188R:R:S136 5.0725411
189R:R:P137 7.5925413
190R:R:E138 8.5375412
191R:R:L141 5.1515
192R:R:L144 9.0875416
193R:R:Y145 6.8975415
194R:R:Y152 5.74833697
195R:R:F156 4.6407
196R:R:L159 3.8775409
197R:R:R176 6.894509
198R:R:H180 7.5475409
199R:R:F187 9.1865298
200R:R:R190 8.794598
201R:R:D198 6.5325417
202R:R:Y205 6.418513
203R:R:W214 8.2075411
204R:R:Q221 10.93414
205R:R:Y241 10.125498
206R:R:W243 13.285229
207R:R:E247 10.725409
208R:R:Y250 8.2985188
209R:R:Y269 6.174507
210R:R:W274 8.048336229
211R:R:F280 7.6525405
212R:R:W284 7.71286718
213R:R:K288 9.2418
214R:R:W297 8.89833618
215R:R:Y305 8.81404
216R:R:W306 8.9325406
217R:R:F324 9.534319
218R:R:K334 7.2565249
219R:R:H363 10.74598
220R:R:F367 6.1825497
221R:R:C403 4.324289
222R:R:F404 3.765288
223R:R:K415 6.724267
224R:R:R419 5.3554267
225L:L:?99 8.012631910
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D76 B:B:H54 13.13926.3YesYes399
2B:B:H54 B:B:W82 13.59183.17YesYes399
3B:B:L70 B:B:W82 16.42815.69NoYes359
4B:B:L70 B:B:M61 15.99485.65NoYes356
5B:B:C317 B:B:M61 19.09124.86NoYes076
6B:B:C317 B:B:S316 19.44633.44NoNo079
7B:B:S316 B:B:W332 19.62624.94NoYes099
8B:B:W332 B:B:Y59 72.51712.54YesYes298
9B:B:L284 B:B:V296 10.87975.96YesNo1355
10B:B:G306 B:B:V296 13.03081.84NoNo045
11B:B:G306 B:B:V307 13.22111.84NoYes043
12B:B:N293 B:B:V307 21.45934.43NoYes053
13B:B:A309 B:B:N293 1003.13NoNo035
14B:B:A309 R:R:R419 99.94534.15NoYes037
15B:B:D312 R:R:R419 99.36123.57NoYes2657
16B:B:D312 R:R:H171 99.558322.69NoNo057
17R:R:E412 R:R:H171 99.502412.31NoNo087
18R:R:E412 R:R:L172 99.39023.98NoNo089
19R:R:L172 R:R:V409 99.33385.96NoNo099
20R:R:N406 R:R:V409 97.55058.87NoNo099
21R:R:E408 R:R:N406 97.43389.2NoNo099
22R:R:E408 R:R:R176 97.37655.82NoYes099
23A:A:Q390 R:R:R176 39.72335.84NoYes049
24A:A:H387 A:A:Q390 30.0416.18YesNo1884
25A:A:H387 A:A:I383 46.96543.98YesNo088
26A:A:H41 A:A:I383 45.22665.3NoNo068
27A:A:F219 A:A:H41 44.56173.39YesNo086
28A:A:F212 A:A:F219 43.631516.08NoYes098
29A:A:F212 A:A:I372 42.92635.02NoNo2398
30A:A:I372 A:A:M60 42.73427.29NoNo089
31B:B:M101 B:B:Y59 67.45023.59YesYes298
32A:A:I56 A:A:M60 36.01054.37YesNo079
33A:A:A366 A:A:I56 35.55013.25NoYes597
34A:A:A366 A:A:T55 37.3183.36NoNo099
35A:A:T55 A:A:V191 36.56317.93NoNo093
36A:A:P192 A:A:V191 35.55813.53YesNo093
37A:A:I95 A:A:P192 30.1425.08YesYes679
38A:A:F178 A:A:I95 29.6866.28YesYes677
39A:A:D378 A:A:Y360 11.744617.24NoYes078
40A:A:H149 A:A:Y130 10.401410.89YesNo051
41A:A:H149 A:A:I131 11.98153.98YesNo054
42A:A:I103 A:A:I131 13.86972.94NoNo064
43A:A:I103 A:A:I106 15.20812.94NoYes067
44A:A:I106 A:A:Y169 18.10693.63YesYes1976
45A:A:S166 A:A:Y169 22.65695.09NoYes1986
46A:A:S166 A:A:Y163 24.26848.9NoYes084
47A:A:W154 A:A:Y163 25.04933.86YesYes094
48A:A:L179 A:A:W154 26.366517.08NoYes079
49A:A:L179 A:A:L99 26.62814.15NoNo076
50A:A:F178 A:A:L99 26.88956.09YesNo076
51B:B:M101 B:B:Y145 65.85939.58YesYes298
52A:A:W234 B:B:Y145 39.42695.79YesYes298
53A:A:R231 A:A:W234 39.156911NoYes099
54A:A:L272 A:A:R231 38.97828.5NoNo089
55A:A:W281 B:B:W332 42.69679.37YesYes259
56B:B:R314 B:B:W332 44.28720.99YesYes289
57A:A:F246 A:A:L272 38.62046.09NoNo098
58A:A:F246 A:A:V248 11.07255.24NoNo097
59A:A:F246 A:A:F273 27.38097.5NoYes099
60A:A:F345 A:A:V248 10.50617.87YesNo087
61A:A:F273 A:A:F345 10.53558.57YesYes098
62A:A:L289 A:A:L291 11.10558.3NoNo098
63A:A:L291 A:A:S250 10.52094.5NoNo086
64A:A:F345 A:A:L270 12.87939.74YesNo086
65A:A:W281 B:B:D290 42.935610.05YesYes256
66B:B:D290 B:B:R314 45.999413.1YesYes268
67A:A:Y391 R:R:R176 11.364912.35YesYes049
68B:B:L252 B:B:Y264 24.3645.86NoYes075
69B:B:L252 B:B:L261 24.14954.15NoNo075
70B:B:D254 B:B:L261 23.9358.14NoNo095
71B:B:A257 B:B:D254 22.11794.63NoNo079
72B:B:A257 B:B:Q259 21.90193.03NoYes076
73B:B:Q259 B:B:R22 21.25298.18YesNo066
74B:B:D258 B:B:R22 14.66615.48YesNo076
75B:B:G162 B:B:Y145 27.142610.14NoYes298
76B:B:G162 B:B:S161 27.02453.71NoNo299
77B:B:H142 B:B:S161 25.432613.95YesNo299
78B:B:C149 B:B:T102 14.97815.07NoNo088
79B:B:C148 B:B:T102 14.5763.38NoNo068
80B:B:H142 B:B:W169 17.06986.35YesYes298
81B:B:I157 B:B:W169 13.10333.52YesYes078
82B:B:C148 B:B:S160 13.77133.44NoNo066
83B:B:S160 B:B:V187 12.96614.85NoYes069
84B:B:C271 B:B:D290 88.92414.67NoYes256
85B:B:C271 B:B:Y289 16.58794.03NoYes257
86B:B:N295 B:B:V307 12.38384.43YesYes063
87B:B:W297 B:B:Y264 32.629616.4NoYes085
88B:B:W297 B:B:Y289 22.98235.79NoYes287
89B:B:C271 B:B:D291 72.33197.78NoNo258
90R:R:H180 R:R:R176 62.0725.64YesYes099
91R:R:E247 R:R:H180 57.981513.54YesYes099
92R:R:E247 R:R:L183 58.717310.6YesNo099
93R:R:F187 R:R:L183 58.25866.09YesNo2989
94R:R:F187 R:R:N240 55.635918.12YesNo089
95R:R:N240 R:R:R190 66.278910.85NoYes098
96R:R:R190 R:R:Y152 65.0425.14YesYes987
97R:R:V194 R:R:Y152 63.782610.09NoYes077
98R:R:D198 R:R:V194 63.61014.38YesNo077
99L:L:?99 R:R:D198 62.84025.66YesYes107
100L:L:?99 R:R:Y205 50.81033.8YesYes103
101R:R:L32 R:R:Y205 50.622314.07NoYes043
102R:R:L32 R:R:T35 15.30194.42NoNo045
103R:R:P90 R:R:T35 15.10033.5YesNo045
104R:R:L32 R:R:W214 35.14293.42NoYes041
105R:R:W214 R:R:W39 18.51785.62YesYes115
106R:R:W39 R:R:Y88 16.486710.61YesYes155
107R:R:Q211 R:R:W214 16.64516.43NoYes141
108R:R:Q211 R:R:Y88 16.44325.64NoYes145
109R:R:L89 R:R:P90 14.28253.28YesYes154
110R:R:P86 R:R:Y88 11.670511.13YesYes185
111R:R:D67 R:R:Y69 22.60533.45YesYes196
112R:R:D67 R:R:R102 16.9583.57YesYes198
113R:R:R102 R:R:W110 13.832821.99YesNo089
114R:R:C62 R:R:W110 13.216516.98NoNo099
115R:R:C104 R:R:C62 10.07577.28NoNo099
116R:R:Y69 R:R:Y88 16.70533.97YesYes165
117R:R:C85 R:R:P86 16.95391.88YesYes098
118R:R:C85 R:R:G98 13.19591.96YesNo094
119R:R:G98 R:R:H99 12.5691.59NoYes044
120R:R:H99 R:R:Y101 10.68755.44YesNo045
121R:R:I179 R:R:Y250 15.21638.46NoYes088
122R:R:I179 R:R:V246 12.90474.61NoNo088
123R:R:Y250 R:R:Y269 11.44069.93YesYes087
124R:R:V246 R:R:W243 22.4127.36NoYes089
125R:R:S186 R:R:W243 11.18857.41NoYes2299
126R:R:N240 R:R:S186 11.20094.47NoNo099
127B:B:D291 B:B:N293 82.71695.39NoNo085
128A:A:H387 R:R:L254 17.455225.71YesNo1888
129R:R:L254 R:R:Y250 17.474512.89NoYes1888
130B:B:D291 B:B:Y289 10.41393.45NoYes287
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:P137 R:R:T29 10.49 1 Yes No 3 2 1 2
R:R:Q140 R:R:T29 5.67 0 No No 4 2 2 2
R:R:S136 R:R:S31 3.26 1 Yes No 1 4 2 2
R:R:S31 R:R:Y205 5.09 0 No Yes 4 3 2 1
R:R:L32 R:R:Y205 14.07 0 No Yes 4 3 2 1
R:R:Q37 R:R:W33 7.67 1 Yes Yes 4 3 2 1
R:R:Q221 R:R:W33 25.19 1 Yes Yes 4 3 2 1
R:R:C296 R:R:W33 3.92 1 No Yes 9 3 2 1
R:R:T298 R:R:W33 13.34 1 No Yes 5 3 1 1
L:L:?99 R:R:W33 20.57 1 Yes Yes 0 3 0 1
L:L:?99 R:R:E34 5.52 1 Yes No 0 4 0 1
R:R:Q221 R:R:Q37 10.24 1 Yes Yes 4 4 2 2
R:R:P137 R:R:S136 5.34 1 Yes Yes 3 1 1 2
R:R:E138 R:R:S136 10.06 1 Yes Yes 2 1 1 2
R:R:E138 R:R:P137 3.14 1 Yes Yes 2 3 1 1
L:L:?99 R:R:P137 11.4 1 Yes Yes 0 3 0 1
R:R:E138 R:R:Y205 5.61 1 Yes Yes 2 3 1 1
L:L:?99 R:R:E138 15.34 1 Yes Yes 0 2 0 1
R:R:L141 R:R:Q140 5.32 1 Yes No 5 4 1 2
R:R:L141 R:R:L144 4.15 1 Yes Yes 5 6 1 1
R:R:F381 R:R:L141 3.65 0 No Yes 4 5 2 1
L:L:?99 R:R:L141 9.61 1 Yes Yes 0 5 0 1
R:R:F385 R:R:L144 25.58 0 No Yes 6 6 2 1
L:L:?99 R:R:L144 3.85 1 Yes Yes 0 6 0 1
R:R:Y145 R:R:Y148 7.94 1 Yes No 5 7 1 1
R:R:D198 R:R:Y145 10.34 1 Yes Yes 7 5 1 1
L:L:?99 R:R:Y145 8.14 1 Yes Yes 0 5 0 1
R:R:D198 R:R:Y148 5.75 1 Yes No 7 7 1 1
L:L:?99 R:R:Y148 3.8 1 Yes No 0 7 0 1
R:R:D198 R:R:V194 4.38 1 Yes No 7 7 1 2
R:R:K197 R:R:M233 8.64 1 No No 6 6 1 1
L:L:?99 R:R:K197 10.45 1 Yes No 0 6 0 1
L:L:?99 R:R:D198 5.66 1 Yes Yes 0 7 0 1
R:R:L201 R:R:Y205 3.52 1 No Yes 7 3 1 1
L:L:?99 R:R:L201 8.33 1 Yes No 0 7 0 1
L:L:?99 R:R:K202 7.83 1 Yes No 0 4 0 1
R:R:M204 R:R:Y220 11.97 0 No No 3 3 2 1
L:L:?99 R:R:Y205 3.8 1 Yes Yes 0 3 0 1
R:R:C226 R:R:Y220 12.1 0 No No 9 3 2 1
L:L:?99 R:R:Y220 7.6 1 Yes No 0 3 0 1
R:R:C226 R:R:C296 7.28 0 No No 9 9 2 2
L:L:?99 R:R:V229 4.83 1 Yes No 0 7 0 1
R:R:F230 R:R:Q234 9.37 1 No No 5 7 1 2
R:R:F230 R:R:W284 7.02 1 No Yes 5 8 1 2
L:L:?99 R:R:F230 5.08 1 Yes No 0 5 0 1
L:L:?99 R:R:M233 3.27 1 Yes No 0 6 0 1
R:R:Q234 R:R:W284 10.95 1 No Yes 7 8 2 2
R:R:C296 R:R:T298 3.38 1 No No 9 5 2 1
L:L:?99 R:R:T298 15.7 1 Yes No 0 5 0 1
R:R:F381 R:R:F385 6.43 0 No No 4 6 2 2
R:R:M233 R:R:S193 3.07 1 No No 6 6 1 2
R:R:L141 R:R:L384 2.77 1 Yes No 5 5 1 2
R:R:L144 R:R:L384 2.77 1 Yes No 6 5 1 2
L:L:?99 R:R:A200 1.46 1 Yes No 0 4 0 1
R:R:L142 R:R:Y145 1.17 0 No Yes 3 5 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
94.44Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
82.35Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
55.56Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
45.45Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
44.00Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
42.31Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
41.67Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
41.67Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
41.38Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
39.29Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
39.13Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
37.50Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
37.04Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
37.04Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
37.04Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
36.67Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
35.71Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
35.71Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
35.71Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
35.48Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
35.00Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
34.48Single4XT3Fractalkine4XT3-US28-Fractalkine
34.48Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
34.48Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
34.38Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
33.33Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
33.33Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
33.33Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
33.33Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
33.33Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
33.33Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
33.33Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
33.33Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
33.33Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
33.33Single8K5DGSK2560738K5D-HCA2-GSK256073
32.26Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
32.14Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
32.14Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
31.82Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
31.58Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
31.58Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
31.58Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
31.25Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
31.03Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
31.03Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
31.03Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
31.03Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
30.77Single4XT1Fractalkine4XT1-US28-Fractalkine
30.43Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
30.43Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
30.30Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
30.00Single6FJ3PTH6FJ3-PTH1-PTH
30.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
30.00Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
30.00Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
30.00Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
30.00Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
30.00Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
30.00Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
30.00Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
30.00Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
30.00Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
29.63Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
29.63Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
29.63Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
29.63Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
29.41Single8HS2Fab0468HS2-GPR20-Fab046
29.41Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
29.17Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
29.17Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
29.17Single8XYIVUF106618XYI-CXCR3-VUF10661
29.03Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
29.03Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
29.03Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
29.03Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
29.03Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
29.03Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
28.57Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
28.57Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
28.57Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
28.12Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
28.12Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
28.12Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
28.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
28.00Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
27.59Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
27.59Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
27.59Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
27.27Single4YAYZD-71554YAY-AT1-ZD-7155
27.27Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
27.27Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
27.27Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
27.27Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
27.27Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
27.27Single7YXAONO-54306087YXA-S1P5-ONO-5430608
27.27Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
27.27Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
27.27Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
27.27Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
27.27Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
27.27Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
27.27Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
27.27Consensushca_on_gpOrthosteric Ligandhca2_on_gp
26.92Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
26.67Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
26.67Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
26.67Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
26.67Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
26.67Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
26.67Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
26.47Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
26.47Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
26.32Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
26.09Single7C4SS1P7C4S-S1P3-S1P
26.09Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
26.09Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
26.09Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
26.09Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
26.09Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
26.09Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
26.09Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
26.09Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
25.93Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
25.93Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
25.81Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
25.81Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
25.81Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
25.81Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
25.81Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
25.00Single3OE9IT1t3OE9-CXCR4-IT1t
25.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
25.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
25.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
25.00Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
25.00Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
25.00Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
25.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
25.00Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
25.00Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
25.00Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
25.00Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
25.00Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
25.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
25.00Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
25.00Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
25.00Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
25.00Single9BJKNAM9BJK-μ-Naloxone-NAM
25.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
25.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
25.00Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
25.00Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
25.00Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
24.24Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
24.24Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
24.24Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
24.24Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
24.24Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
24.24Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
24.24Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
24.14Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
24.14Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
24.14Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
24.14Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
24.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
24.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
24.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
24.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
24.00Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
24.00Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
24.00Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
24.00Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
24.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
23.81Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
23.81Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
23.81Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
23.81Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
23.81Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
23.68Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
23.68Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
23.33Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
23.33Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
23.33Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
23.33Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
23.33Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
23.33Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
23.33Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
23.33Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
23.08Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
23.08Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
23.08Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
23.08Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
23.08Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
23.08Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
23.08Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
23.08Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
22.86Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
22.86Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
22.86Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
22.73Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
22.73Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
22.73Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
22.73Single8IHKAcifran8IHK-HCA3-Acifran
22.73Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
22.73Single8K5CAcipimox8K5C-HCA2-Acipimox
22.73Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
22.73Consensushca_onOrthosteric Ligandhca2_on
22.73Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
22.58Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
22.58Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
22.58Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
22.58Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
22.58Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
22.50Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
22.22Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
22.22Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
22.22Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
22.22Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
22.22Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
22.22Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
22.22Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
22.22Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
22.22Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
22.22Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.22Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
22.22Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
21.95Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
21.88Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
21.88Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
21.88Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
21.74Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
21.74Single7F83PF-051904577F83-Ghrelin-PF-05190457
21.74Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
21.74Single7V3ZCP559407V3Z-CB1-CP55940
21.74Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
21.74Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
21.74Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
21.74Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
21.74Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
21.74Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
21.74Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
21.62Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
21.62Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.43Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
21.43Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
21.43Single8KIGSHU91198KIG-MC3-SHU9119-Ca
21.43Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
21.43Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
21.43Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
21.43Consensuslpl_onOrthosteric Ligands1p_on lpa_on
21.43Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
21.43Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
21.43Consensussomatostatin_offOrthosteric Ligandsst2_off
21.21Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
21.21Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
21.21Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
21.21Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
21.21Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
21.21Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
21.05Single3OE8IT1t3OE8-CXCR4-IT1t
21.05Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
20.83Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
20.83Single5WIUNemonapride5WIU-D4-Nemonapride
20.83Single5WIVNemonapride5WIV-D4-Nemonapride-Na
20.83Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
20.83Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
20.83Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
20.83Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
20.83Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
20.83Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
20.83Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
20.83Consensusblt_offOrthosteric Ligandblt1_off
20.83Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
20.83Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
20.83Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
20.83Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
20.83Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
20.69Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
20.69Single7XNACYN1548067XNA-SST2-CYN154806
20.69Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
20.69Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
20.69Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
20.69Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
20.69Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
20.69Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
20.69Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
20.69Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
20.69Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
20.69Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
20.59Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
20.59Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
20.45Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
20.00Single3OE6IT1t3OE6-CXCR4-IT1t
20.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
20.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
20.00Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
20.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
20.00Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
20.00Single6W25SHU91196W25-MC4-SHU9119-Ca
20.00Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
20.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
20.00Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
20.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
20.00Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
20.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
20.00Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
20.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
20.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
20.00Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
20.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
20.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
20.00Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
20.00Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.00Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.00Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.00Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
20.00Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
20.00Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusangiotensin_onOrthosteric Ligandat1_on
20.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
20.00Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
20.00Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
20.00Consensusbombesin_onOrthosteric Ligandbb2_on
20.00Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
20.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
20.00Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
20.00Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
20.00Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
20.00Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
20.00Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
20.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
20.00Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
20.00Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
20.00Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
20.00Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
20.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
20.00Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
19.44Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
19.44Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
19.35Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
19.35Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
19.35Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
19.35Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
19.35Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
19.35Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
19.35Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
19.35Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
19.35Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
19.35Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
19.23Single4XEENeurotensin4XEE-NTS1-Neurotensin
19.23Single4XESNeurotensin4XES-NTS1-Neurotensin
19.23Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
19.23Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
19.23Single6KQICP559406KQI-CB1-CP55940-Org27569
19.23Single6OS2TRV0266OS2-AT1-TRV026
19.23Single6YVRNTS8-136YVR-NTS1-NTS8-13
19.23Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
19.23Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
19.23Single7K15MKD0467K15-BLT1-MKD046-Na
19.23Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.23Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
19.23Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
19.23Single8JWZAB9288JWZ-A2A-AB928-Na
19.23Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
19.23Consensusalpha1_offOrthosteric Ligandalpha1a_off
19.23Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
19.23Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
19.23Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
19.23Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
19.23Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
19.23Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
19.23Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
19.23Consensuslpa_offOrthosteric Ligandlpa1_off
19.23Consensuslpl_offOrthosteric Ligands1p_off lpa_off
19.23Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
19.23Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
19.23Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
19.23Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
19.05Single6LI0C176LI0-GPR52-C17
19.05Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
19.05Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
19.05Single8K5BNiacin8K5B-HCA2-Niacin
19.05Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
19.05Consensusgq_nucleotideOrthosteric Ligandgq_p2y
19.05Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
18.92Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
18.75Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
18.75Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
18.75Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
18.75Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
18.75Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
18.75Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
18.75Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
18.75Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
18.75Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.52Single4BUONeurotensin4BUO-NTS1-Neurotensin
18.52Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
18.52Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
18.52Single6K1QIRL25006K1Q-ETB-IRL2500
18.52Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
18.52Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
18.52Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
18.52Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
18.52Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
18.52Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
18.52Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
18.52Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
18.52Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
18.52Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
18.52Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
18.52Consensusprostanoid_offOrthosteric Ligandep_off dp_off
18.18Single3ODUIT1t3ODU-CXCR4-IT1t
18.18Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
18.18Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
18.18Single5ZKQABT-4915ZKQ-PAF-ABT-491
18.18Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
18.18Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
18.18Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
18.18Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
18.18Single7XRRLemborexant7XRR-OX2-Lemborexant
18.18Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
18.18Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
18.18Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
18.18Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
18.18Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
18.18Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
18.18Consensusangiotensin_offOrthosteric Ligandat1_off
18.18Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
18.18Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
18.18Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
18.18Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
18.18Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
17.86Single5EE7MK08935EE7-Glucagon-MK0893
17.86Single5ZTYAM102575ZTY-CB2-AM10257
17.86Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
17.86Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
17.86Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Single7SK9CCX6627SK9-ACKR3-CCX662
17.86Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
17.86Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single8QJ2pN1628QJ2-MC4-pN162-Gs
17.86Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
17.86Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
17.86Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
17.86Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
17.86Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
17.86Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
17.65Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
17.65Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
17.65Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
17.65Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
17.65Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
17.39Single6IQLL7458706IQL-D4-L745870
17.39Single6TP3Nemorexant6TP3-OX1-Nemorexant
17.39Single6V9SGTPL114036V9S-OX1-GTPL11403
17.39Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
17.39Single6ZG9GSK10347026ZG9-M1-GSK1034702
17.39Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
17.39Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
17.39Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
17.39Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
17.39Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
17.39Single8K2WAMG4878K2W-CXCR3-AMG487
17.39Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
17.39Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
17.39Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
17.39Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
17.24Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
17.24Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
17.24Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
17.24Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
17.24Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
17.24Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
17.24Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
17.24Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
17.24Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.24Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
17.24Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
17.24Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
17.24Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.14Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
17.14Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
17.14Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
17.14Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
16.67Single2Y04Salbutamol2Y04-β1-Salbutamol
16.67Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
16.67Single4QKX35V4QKX-β2-35V
16.67Single5DHGC-355DHG-NOP-C-35
16.67Single5GLHEndothelin-15GLH-ETB-Endothelin-1
16.67Single5T04Neurotensin5T04-NTS1-Neurotensin
16.67Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
16.67Single6D27CAY104716D27-DP2-CAY10471
16.67Single6GPSMK08126GPS-CCR2-MK0812
16.67Single6TOTLemborexant6TOT-OX1-Lemborexant
16.67Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
16.67Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
16.67Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
16.67Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
16.67Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
16.67Single7SK5CXCL127SK5-ACKR3-CXCL12
16.67Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
16.67Single7UL4Alvimopan7UL4-μ-Alvimopan
16.67Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
16.67Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
16.67Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
16.67Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
16.67Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
16.67Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
16.67Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
16.67Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
16.67Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
16.67Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
16.67Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
16.67Single8RLNLUF58348RLN-A2A-LUF5834
16.67Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
16.67Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
16.67Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
16.67Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
16.67Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
16.67Single9B9ZA1AKO9B9Z-CB1-A1AKO
16.67Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
16.67Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
16.67Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
16.67Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
16.67Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
16.67Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
16.67Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
16.67Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
16.67Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
16.67Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
16.67Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
16.67Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
16.67Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
16.67Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
16.67Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
16.22Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
16.13Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
16.13Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
16.13Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
16.13Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
16.13Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
16.13Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
16.13Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
16.13Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
16.13Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
16.00Single2Y00Dobutamine2Y00-β1-Dobutamine
16.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
16.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
16.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
16.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
16.00Single6GPXMK08126GPX-CCR2-MK0812
16.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
16.00Single6TP6Filorexant6TP6-OX1-Filorexant
16.00Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
16.00Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
16.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
16.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
16.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
16.00Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
16.00Single8JXSPF-61428JXS-D1-PF-6142
16.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
16.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
16.00Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
16.00Consensusdp_offOrthosteric Liganddp2_off
16.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
16.00Consensusep_offOrthosteric Ligandep4_off
16.00Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
16.00Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
15.79Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
15.79Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
15.62Single6JODAngiotensin II6JOD-AT2-Angiotensin II
15.62Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
15.62Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
15.62Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
15.62Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
15.62Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.62Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.62Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
15.62Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
15.62Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
15.62Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
15.62Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
15.62Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
15.62Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
15.62Consensusvasop-oxy_onOrthosteric Ligandv2_on
15.62Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
15.38Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
15.38Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
15.38Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
15.38Single4BV0Neurotensin4BV0-NTS1-Neurotensin
15.38Single4DJHJDTic4DJH-κ-JDTic
15.38Single5XR8AM8415XR8-CB1-AM841
15.38Single5XRAAM115425XRA-CB1-AM11542
15.38Single6H7JIsoprenaline6H7J-β1-Isoprenaline
15.38Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
15.38Single6OS1TRV0266OS1-AT1-TRV026
15.38Single7B6WCyclazosin7B6W-α1b-Cyclazosin
15.38Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
15.38Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
15.38Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
15.38Single7FEECP559407FEE-CB1-CP55940-ZCZ011
15.38Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
15.38Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
15.38Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
15.38Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
15.38Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
15.38Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
15.38Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
15.38Single8E0GBU728E0G-μ-BU72
15.38Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
15.38Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
15.38Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
15.38Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
15.38Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
15.38Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
15.38Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
15.38Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
15.38Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
15.38Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
15.38Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
15.38Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
15.38Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
15.38Consensuslpa_onOrthosteric Ligandlpa1_on
15.38Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
15.38Consensusneurotensin_onOrthosteric Ligandnts1_on
15.38Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
15.38Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
15.38Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
15.15Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
15.15Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
15.15Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
15.15Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
15.15Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
15.15Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
15.15Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single8ZRTET-18ZRT-ETB-ET-1
15.15Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
15.15Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
15.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
14.81Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
14.81Single4LDEBI1671074LDE-β2-BI167107
14.81Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
14.81Single5X33BIIL2605X33-BLT1-BIIL260
14.81Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
14.81Single6IIURamatroban6IIU-TP-Ramatroban
14.81Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
14.81Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
14.81Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
14.81Single6ZG4HTL00099366ZG4-M1-HTL0009936
14.81Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
14.81Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
14.81Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
14.81Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
14.81Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
14.81Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
14.81Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
14.81Single8JJLOlodaterol8JJL-β2-Olodaterol
14.81Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
14.81Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
14.81Single8JWY2-1188JWY-A2A-2-118
14.81Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
14.81Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
14.81Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
14.81Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
14.81Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
14.81Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
14.81Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
14.81Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
14.81Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
14.81Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
14.81Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
14.81Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
14.81Consensusorexin_onOrthosteric Ligandox2_on
14.71Single7SK3CXCL127SK3-ACKR3-CXCL12
14.71Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
14.71Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
14.71Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
14.29Single5X93K-87945X93-ETB-K-8794
14.29Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
14.29Single6H7LDobutamine6H7L-β1-Dobutamine
14.29Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
14.29Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
14.29Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
14.29Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
14.29Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
14.29Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
14.29Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
14.29Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
14.29Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
14.29Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
14.29Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
14.29Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
14.29Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
14.29Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
14.29Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
14.29Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
14.29Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
14.29Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
14.29Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
14.29Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
14.29Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
14.29Consensuscck_onOrthosteric Ligandccka_on cckb_on
14.29Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
14.29Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
14.29Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
14.29Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
14.29Consensusendothelin_offOrthosteric Ligandetb_off
14.29Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
14.29Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
14.29Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
14.29Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
14.29Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
14.29Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Single6IGLIRL16206IGL-ETB-IRL1620
13.89Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
13.89Single8IY6Endothelin-18IY6-ETB-Endothelin-1
13.89Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
13.89Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
13.89Consensusbradykinin_onOrthosteric Ligandbk2_on
13.89Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
13.89Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
13.79Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
13.79Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
13.79Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
13.79Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
13.79Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
13.79Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
13.79Single8X5YAstemizole8X5Y-H1-Astemizole
13.79Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
13.79Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
13.79Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
13.79Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
13.79Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
13.64Single6TP4ACT-4622066TP4-OX1-ACT-462206
13.64Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
13.64Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
13.64Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
13.64Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
13.64Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
13.64Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
13.64Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single9B9Y7DY9B9Y-CB1-7DY
13.51Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
13.33Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
13.33Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
13.33Single7F8XNN90567F8X-CCKA-NN9056
13.33Single7QA8Peptide7QA8-STE2-Peptide
13.33Single7QA8Peptide7QA8-STE2-Peptide
13.33Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
13.33Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
13.33Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
13.33Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
13.33Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
13.33Single8WKYPG-9348WKY-MC4-PG-934
13.33Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
13.33Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.33Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
13.33Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
13.33Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
13.16Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
13.16Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
13.04Single4BWBNeurotensin4BWB-NTS1-Neurotensin
13.04Single4S0VSuvorexant4S0V-OX2-Suvorexant
13.04Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
13.04Single5U09Taranabant5U09-CB1-Taranabant
13.04Single5WS3EMPA5WS3-OX2-EMPA
13.04Single6AKXA4R6AKX-CCR5-A4R
13.04Single6AKYMaraviroc6AKY-CCR5-Maraviroc
13.04Single6B73MP11046B73-κ-MP1104
13.04Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
13.04Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
13.04Single6TPJSuvorexant6TPJ-OX2-Suvorexant
13.04Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
13.04Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
13.04Single7BR3Elagolix7BR3-GnRH1-Elagolix
13.04Single7F8YDevazepide7F8Y-CCKA-Devazepide
13.04Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
13.04Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
13.04Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
13.04Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
13.04Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
13.04Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
13.04Single8Y0HVUF114188Y0H-CXCR3-VUF11418
13.04Single9BA0A1AKN9BA0-CB1-A1AKN
13.04Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
13.04Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
13.04Consensusorexin_offOrthosteric Ligandox2_off ox1_off
13.04Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
13.04Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
12.90Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
12.90Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
12.90Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
12.90Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
12.90Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
12.90Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
12.90Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
12.50Single3OE0CVX153OE0-CXCR4-CVX15
12.50Single4MBSMaraviroc4MBS-CCR5-Maraviroc
12.50Single4ZJCSB-6740424ZJC-OX1-SB-674042
12.50Single6KUXRS-799486KUX-α2a-RS-79948
12.50Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
12.50Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
12.50Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
12.50Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
12.50Single6TPGEMPA6TPG-OX2-EMPA
12.50Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
12.50Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
12.50Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
12.50Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
12.50Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
12.50Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
12.50Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
12.50Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
12.50Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
12.50Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
12.50Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
12.50Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
12.50Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
12.50Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
12.50Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
12.50Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
12.50Consensusgrh_offOrthosteric Ligandgnrh1_off
12.50Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
12.50Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
12.50Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
12.50Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
12.50Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
12.12Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
12.12Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
12.12Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
12.12Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
12.12Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
12.12Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
12.12Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
12.00Single2Y01Dobutamine2Y01-β1-Dobutamine
12.00Single2Y02Carmoterol2Y02-β1-Carmoterol
12.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
12.00Single5DHHSB-6121115DHH-NOP-SB-612111
12.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
12.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
12.00Single5TGZAM65385TGZ-CB1-AM6538
12.00Single5UENDU1725UEN-A1-DU172
12.00Single5UIGCmpd-15UIG-A2A-Cmpd-1
12.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
12.00Single6H7MSalbutamol6H7M-β1-Salbutamol
12.00Single6IIVDaltroban6IIV-TP-Daltroban
12.00Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
12.00Single7BU7BI1671077BU7-β1-BI167107
12.00Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
12.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
12.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
12.00Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
12.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
12.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
12.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
12.00Single8CU6LJ-45178CU6-A2A-LJ-4517
12.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
12.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
12.00Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
12.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
12.00Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
12.00Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
12.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
12.00Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
12.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
12.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
12.00Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
12.00Consensuscck_offOrthosteric Ligandccka_off
12.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
12.00Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
11.76Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
11.76Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
11.76Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
11.76Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
11.54Single5C1MBU725C1M-μ-BU72
11.54Single5JQHS-Carazolol5JQH-β2-S-Carazolol
11.54Single5N2SPSB365N2S-A1-PSB36
11.54Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
11.54Single5TVNLSD5TVN-5-HT2B-LSD
11.54Single5WQCEMPA5WQC-OX2-EMPA
11.54Single6E67BI1671076E67-β2-BI167107-Gs (fused)
11.54Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
11.54Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
11.54Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
11.54Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
11.54Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
11.54Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
11.54Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
11.54Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
11.54Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
11.54Single7SINNPS-21437SIN-CaS-NPS-2143
11.54Single7SINNPS-21437SIN-CaS-NPS-2143
11.54Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
11.54Single7W41PD1762527W41-BB2-PD176252
11.54Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
11.54Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
11.54Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
11.54Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
11.54Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
11.54Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
11.54Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
11.54Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
11.54Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
11.54Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
11.54Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
11.54Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
11.54Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
11.54Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
11.54Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
11.54Consensusbombesin_offOrthosteric Ligandbb2_off
11.54Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
11.54Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
11.54Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
11.54Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
11.43Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
11.43Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
11.43Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
11.43Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
11.43Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
11.11Single3P0GBI1671073P0G-β2-BI167107
11.11Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
11.11Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
11.11Single6J20Aprepitant6J20-NK1-Aprepitant
11.11Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
11.11Single6TQ7SB-3348676TQ7-OX1-SB-334867
11.11Single6WGTLSD6WGT-5-HT2A-LSD
11.11Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
11.11Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
11.11Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
11.11Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
11.11Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
11.11Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
11.11Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
11.11Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
11.11Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
11.11Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
11.11Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
11.11Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
11.11Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
11.11Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
11.11Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
11.11Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
11.11Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
11.11Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
11.11Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
11.11Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
11.11Single8XVLZibotentan8XVL-ETA-Zibotentan
11.11Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
11.11Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
11.11Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
11.11Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
11.11Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
11.11Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
11.11Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
11.11Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
11.11Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
11.11Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
11.11Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
10.81Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
10.81Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Consensusendothelin_onOrthosteric Ligandetb_on eta_on
10.81Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
10.71Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
10.71Single4AMIBucindolol4AMI-β1-Bucindolol
10.71Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
10.71Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
10.71Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
10.71Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
10.71Single7DFPSpiperone7DFP-D2-Spiperone
10.71Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
10.71Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
10.71Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
10.71Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
10.71Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
10.71Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
10.71Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
10.71Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
10.71Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.71Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
10.71Single7YITNalfurafine7YIT-κ-Nalfurafine
10.71Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
10.71Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
10.71Single8JJ8Formoterol8JJ8-β2-Formoterol
10.71Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
10.71Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
10.71Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
10.71Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
10.71Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
10.71Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
10.71Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
10.71Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
10.71Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
10.71Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
10.71Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
10.71Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
10.71Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
10.71Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.71Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.53Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
10.53Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
10.53Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
10.53Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
10.34Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
10.34Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
10.34Single6IBLArformoterol6IBL-β1-Arformoterol
10.34Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
10.34Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
10.34Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
10.34Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
10.34Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
10.34Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
10.34Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.34Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
10.34Single7UM4AS26747237UM4-5-HT5A-AS2674723
10.34Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
10.34Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
10.34Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
10.34Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.34Consensuschemerin_onOrthosteric Ligandcml1_on
10.34Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
10.34Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
10.26Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
10.00Single4UG2CGS216804UG2-A2A-CGS21680
10.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
10.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
10.00Single6VCBLSN31604406VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
10.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
10.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
10.00Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
10.00Single7XN9L-054,5227XN9-SST2-L-054,522
10.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
10.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
10.00Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
10.00Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
10.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
10.00Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
10.00Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
10.00Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
9.68Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
9.68Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
9.68Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
9.68Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
9.68Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
9.68Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
9.68Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
9.68Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
9.68Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
9.68Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
9.68Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
9.68Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
9.68Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
9.68Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
9.68Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
9.68Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
9.52Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
9.52Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
9.52Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
9.52Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
9.52Consensussensory_onOrthosteric Ligandopsins_on
9.38Single6HLOAprepitant6HLO-NK1-Aprepitant
9.38Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
9.38Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
9.38Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
9.38Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
9.09Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
9.09Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
9.09Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
9.09Single6PT2KGCHM076PT2-δ-KGCHM07
9.09Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
9.09Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single7WC5Psilocin7WC5-5-HT2A-Psilocin
9.09Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
9.09Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
9.09Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
9.09Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
9.09Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
9.09Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
9.09Consensusgi_sensoryOrthosteric Ligandgi_opsins
9.09Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
9.09Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
9.09Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
9.09Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
9.09Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
8.82Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
8.82Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
8.82Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
8.82Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
8.70Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
8.70Single3PBLEticlopride3PBL-D3-Eticlopride
8.70Single4O9RCyclopamine4O9R-SMO-Cyclopamine
8.70Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
8.70Single6HLLCP999946HLL-NK1-CP99994
8.70Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
8.70Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
8.70Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
8.70Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
8.70Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
8.70Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
8.70Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
8.70Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
8.70Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
8.70Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
8.70Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
8.70Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
8.70Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
8.70Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
8.57Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
8.57Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.57Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
8.57Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
8.33Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
8.33Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
8.33Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
8.33Single3PWHZM-2413853PWH-A2A-ZM-241385
8.33Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
8.33Single4QINSAG1.54QIN-SMO-SAG1.5
8.33Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
8.33Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
8.33Single6DS0Ly2660976DS0-5-HT2B-Ly266097
8.33Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
8.33Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
8.33Single6TODEMPA6TOD-OX1-EMPA-Na
8.33Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
8.33Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
8.33Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
8.33Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
8.33Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
8.33Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
8.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
8.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
8.33Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
8.33Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
8.33Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
8.33Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
8.33Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
8.33Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
8.33Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
8.33Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
8.33Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
8.33Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.33Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.33Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
8.33Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
8.33Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
8.33Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
8.33Single8GNGIstradefylline8GNG-A2A-Istradefylline
8.33Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
8.33Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
8.33Single8IWESpermidine8IWE-TA9-Spermidine
8.33Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
8.33Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
8.33Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.33Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.33Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
8.33Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
8.33Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
8.33Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
8.33Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
8.33Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
8.33Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
8.33Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
8.33Consensusalpha2_offOrthosteric Ligandalpha2c_off
8.33Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
8.33Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
8.33Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
8.33Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
8.33Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
8.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
8.00Single2YDOAdenosine2YDO-A2A-Adenosine
8.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
8.00Single3REYXAC3REY-A2A-XAC
8.00Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
8.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
8.00Single6A94Zotepine6A94-5-HT2A-Zotepine
8.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
8.00Single6PS0S-Carazolol6PS0-β2-S-Carazolol
8.00Single6PS4ICI118-5516PS4-β2-ICI118-551
8.00Single6PS5S-Propranolol6PS5-β2-S-Propranolol
8.00Single6TPKRetosiban6TPK-OT-Retosiban
8.00Single6TPNHTL66416TPN-OX2-HTL6641
8.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
8.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
8.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
8.00Single7AROLUF58337ARO-A2A-LUF5833-Na
8.00Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
8.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
8.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
8.00Single7UL3Famotidine7UL3-H2-Famotidine
8.00Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
8.00Single7VODCariprazine7VOD-5-HT2A-Cariprazine
8.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
8.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
8.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
8.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
8.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
8.00Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
8.00Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
8.00Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
8.00Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
8.00Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
8.00Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
8.00Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
8.00Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
8.00Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.00Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.00Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
8.00Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
8.00Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
8.00Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
8.00Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
8.00Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
8.00Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
8.00Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
8.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
8.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
8.00Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
8.00Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
8.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
8.00Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.00Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.00Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.00Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.00Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.00Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
8.00Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
8.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
8.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
8.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
8.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
8.00Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
8.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
8.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
8.00Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
8.00Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
8.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
8.00Consensusopsins_offOrthosteric Ligandrhodopsin_off
8.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
8.00Consensussensory_offOrthosteric Ligandopsins_off
8.00Consensusvasop-oxy_offOrthosteric Ligandot_off
7.89Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
7.69Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
7.69Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
7.69Single3NY8ICI118-5513NY8-β2-ICI118-551
7.69Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
7.69Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
7.69Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
7.69Single4GBRS-Carazolol4GBR-β2-S-Carazolol
7.69Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
7.69Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
7.69Single6PS1Timolol6PS1-β2-Timolol
7.69Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
7.69Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
7.69Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
7.69Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
7.69Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
7.69Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
7.69Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
7.69Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
7.69Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
7.69Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
7.69Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
7.69Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
7.69Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
7.69Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
7.69Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
7.69Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
7.69Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
7.69Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
7.69Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.69Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.69Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.69Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.69Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.69Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.69Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.69Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.69Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.69Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.69Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
7.69Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
7.69Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
7.69Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
7.69Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
7.69Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
7.69Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
7.69Single8JJOAlprenolol8JJO-β2-Alprenolol
7.69Single8JXRLSD8JXR-D1-LSD
7.69Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
7.69Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
7.69Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
7.69Single8T1WCVN4248T1W-GPR6-CVN424
7.69Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.69Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.69Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.69Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.69Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.69Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.69Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.69Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
7.69Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
7.69Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
7.69Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
7.69Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
7.69Single9CHXS-Carazolol9CHX-β2-S-Carazolol
7.69Single9IYAONO-97105319IYA-GPR55-ONO-9710531
7.69Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
7.69Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
7.69Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
7.69Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
7.69Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
7.69Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
7.69Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
7.69Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
7.69Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
7.69Consensusblt_onOrthosteric Ligandblt1_on
7.69Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
7.69Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
7.69Consensusdopamine_offOrthosteric Ligandd2_off d3_off
7.69Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
7.69Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
7.69Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
7.69Consensusleukotriene_onOrthosteric Ligandblt_on
7.69Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
7.69Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
7.69Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
7.41Single2RH1S-Carazolol2RH1-β2-S-Carazolol
7.41Single2YCWS-Carazolol2YCW-β1-S-Carazolol
7.41Single4JKVTaladegib4JKV-SMO-Taladegib
7.41Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
7.41Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
7.41Single5D6LS-Carazolol5D6L-β2-S-Carazolol
7.41Single5N2RPSB-365N2R-A2A-PSB-36-Na
7.41Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
7.41Single5XPRBosentan5XPR-ETB-Bosentan
7.41Single6HLPNetupitant6HLP-NK1-Netupitant
7.41Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
7.41Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
7.41Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
7.41Single6PS6Timolol6PS6-β2-Timolol
7.41Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
7.41Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
7.41Single7C61Ergotamine7C61-5-HT1B-Ergotamine
7.41Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
7.41Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
7.41Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
7.41Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
7.41Single7WC6LSD7WC6-5-HT2A-LSD
7.41Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
7.41Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
7.41Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
7.41Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
7.41Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
7.41Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
7.41Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
7.41Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.41Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.41Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.41Single8GNEKW-63568GNE-A2A-KW-6356-Na
7.41Single8QOTNanobody-E8QOT-μ-Nanobody-E
7.41Single8S4DCMF-0198S4D-Apelin-CMF-019
7.41Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
7.41Single8TF5Oleic acid8TF5-GPR6-Oleic acid
7.41Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.41Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.41Single8ZMFA1L108ZMF-5-HT2C-A1L10
7.41Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
7.41Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
7.41Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
7.41Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
7.41Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
7.41Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
7.41Consensusadenosine_offOrthosteric Liganda1_off a2_off
7.41Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
7.41Consensusamine_offonOrthosteric Ligandamine_off amine_on
7.41Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
7.41Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
7.41Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
7.41Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
7.41Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
7.41Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
7.41Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
7.41Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
7.41Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
7.41Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.41Consensustrace-amine_onOrthosteric Ligandta1_on
7.14Single2YDVNECA2YDV-A2A-NECA
7.14Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
7.14Single4UHRCGS216804UHR-A2A-CGS21680
7.14Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
7.14Single5D5AS-Carazolol5D5A-β2-S-Carazolol
7.14Single5D5BS-Carazolol5D5B-β2-S-Carazolol
7.14Single5G53NECA5G53-A2A-NECA-Gs
7.14Single5V54Methiothepin5V54-5-HT1B-Methiothepin
7.14Single5V56TC1145V56-SMO-TC114
7.14Single5V57TC1145V57-SMO-TC114
7.14Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
7.14Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
7.14Single6E59L-7607356E59-NK1-L-760735
7.14Single6J21Aprepitant6J21-NK1-Aprepitant
7.14Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
7.14Single7F1TMIP-1a7F1T-CCR5-MIP-1a
7.14Single7R0CAVP7R0C-V2-AVP-Arrestin2
7.14Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
7.14Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
7.14Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
7.14Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
7.14Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
7.14Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
7.14Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
7.14Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
7.14Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
7.14Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
7.14Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
7.14Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
7.14Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
7.14Consensus5ht1_offOrthosteric Ligand5ht1b_off
7.14Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
7.14Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
7.14Consensusa2_onOrthosteric Liganda2b_on
7.14Consensusa2_on_gpOrthosteric Liganda2b_on_gp
7.14Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
7.14Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
7.14Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
7.14Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
7.14Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
7.14Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
7.14Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
7.14Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
7.14Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
7.14Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.14Consensustachykinin_offOrthosteric Ligandnk1_off
7.14Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
6.90Single3D4STimolol3D4S-β2-Timolol
6.90Single4RWADIPP-NH24RWA-δ-DIPP-NH2
6.90Single6A93Risperidone6A93-5-HT2A-Risperidone
6.90Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
6.90Single6MXTSalmeterol6MXT-β2-Salmeterol
6.90Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
6.90Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
6.90Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
6.90Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
6.90Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
6.90Single8XQJJN2418XQJ-Apelin-JN241
6.90Single8XWMCXCL68XWM-CXCR2-CXCL6
6.90Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
6.90Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
6.90Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
6.90Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
6.90Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
6.90Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
6.67Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
6.67Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
6.67Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
6.67Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
6.67Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
6.67Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
6.67Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
6.67Single8XVUCXCL28XVU-CXCR2-CXCL2
6.67Single8XWFCXCL38XWF-CXCR2-CXCL3
6.67Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
6.67Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
6.67Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
6.45Single3NY9ICI118-5513NY9-β2-ICI118-551
6.45Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
6.45Single6KNMJN241-96KNM-Apelin-JN241-9
6.45Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
6.45Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
6.45Single8IEIA1LYA8IEI-GPR156-A1LYA
6.45Single8XQJJN2418XQJ-Apelin-JN241
6.45Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
6.45Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
6.45Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
6.45Consensuskisspeptin_onOrthosteric Ligandkiss1_on
6.25Single4IARErgotamine4IAR-5-HT1B-Ergotamine
6.25Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
6.25Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
6.25Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
6.25Single8IEBA1LYA8IEB-GPR156-A1LYA
6.25Single8IEIA1LYA8IEI-GPR156-A1LYA
6.25Single8IEPA1LYA8IEP-GPR156-A1LYA
6.25Single8IEPA1LYA8IEP-GPR156-A1LYA
6.25Single8WDTphotoNECA8WDT-A2A-photoNECA
6.25Single8XWNCXCL88XWN-CXCR2-CXCL8
6.25Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
6.25Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
6.06Single3QAKUK-4320973QAK-A2A-UK-432097
6.06Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
6.06Single8IEBA1LYA8IEB-GPR156-A1LYA
6.06Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
5.88Single5WF5UK-4320975WF5-A2A-UK-432097
5.88Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.88Single6D35Cholesterol6D35-SMO-Cholesterol
5.88Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.88Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.88Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
5.88Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
5.88Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
5.88Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.88Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.88Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
5.88Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
5.88Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
5.88Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.88Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.88Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.88Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.88Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
5.88Single7DTTCa7DTT-CaS-Ca-Ca
5.88Single7DTTCa7DTT-CaS-Ca-Ca
5.88Single7DTUTryptophan7DTU-CaS-Tryptophan
5.88Single7DTUTryptophan7DTU-CaS-Tryptophan
5.88Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.88Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.88Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.88Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.88Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.88Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.88Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.88Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.88Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
5.88Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.88Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.88Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.88Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.88Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.88Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.88Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
5.88Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
5.88Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.88Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.88Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.88Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.88Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.88Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.88Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.88Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.88Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.88Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.88Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.88Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.88Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.88Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.88Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.88Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.88Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.88Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.88Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
5.88Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.88Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.88Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.88Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.88Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.88Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.88Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
5.88Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
5.88Single7XW7K1-707XW7-TSH-K1-70
5.88Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.88Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.88Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.88Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.88Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.88Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.88Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.88Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.88Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.88Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.88Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.88Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.88Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
5.88Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.88Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.88Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.88Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.88Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
5.88Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
5.88Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.88Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.88Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
5.88Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
5.88Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
5.88Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
5.88Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.88Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.88Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.88Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
5.88Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
5.88Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
5.88Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
5.88Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
5.88Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
5.88Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.88Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.88Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.88Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.88Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.88Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.88Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
5.88Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
5.88Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
5.88Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
5.88Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.88Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.88Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
5.88Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
5.88Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
5.88Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
5.88Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
5.88Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
5.88Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
5.88Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
5.88Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
5.88Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
5.88Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.88Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.88Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single8WVXNorrin8WVX-LGR4-Norrin
5.88Single8WVYNorrin8WVY-LGR4-Norrin
5.88Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.88Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.88Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.88Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.88Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.88Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.88Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
5.88Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
5.88Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.88Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.88Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
5.88Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
5.88Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
5.88Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
5.88Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
5.88Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.88Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.88Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.88Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.88Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.88Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.88Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.88Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.88Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.88Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.88Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.88Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.88Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.88Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.88Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.88Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.88Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
5.88Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
5.88Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.88Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.71Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.71Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
5.71Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
5.56Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.56Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.56Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.56Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.56Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.56Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.56Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.56Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.56Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.56Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.56Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.56Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.26Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
5.26Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
5.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
5.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
5.00Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
5.00Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
5.00Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
5.00Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
5.00Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
5.00Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
4.76Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
4.76Single5L7DCholesterol5L7D-SMO-Cholesterol
4.76Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
4.76Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
4.76Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
4.76Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
4.76Single8PWNTheophylline8PWN-A2A-Theophylline
4.76Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
4.55Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
4.55Single3RFMCaffeine3RFM-A2A-Caffeine
4.55Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.55Single8A2OTheophylline8A2O-A2A-Theophylline-Na
4.55Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
4.55Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
4.55Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
4.55Single9CHUNoradrenaline9CHU-β2-Noradrenaline
4.55Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
4.55Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
4.55Consensusp2y_offOrthosteric Ligandp2y1_off
4.35Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
4.35Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
4.35Single3UZAGTPL92363UZA-A2A-GTPL9236
4.35Single4XNWMRS25004XNW-P2Y1-MRS2500
4.35Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
4.35Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.35Single6ME5Agomelatine6ME5-MT1-Agomelatine
4.35Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
4.35Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
4.35Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
4.35Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
4.35Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
4.35Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
4.35Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
4.35Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
4.35Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
4.35Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
4.35Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
4.35Single8JPSCCL78JPS-ACKR1-CCL7
4.35Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
4.35Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
4.35Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
4.35Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
4.35Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
4.35Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
4.35Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
4.35Consensus5ht2_onOrthosteric Ligand5ht2b_on
4.35Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
4.35Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
4.35Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
4.35Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
4.17Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
4.17Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
4.17Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
4.17Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
4.17Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
4.17Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
4.17Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
4.17Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.17Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
4.17Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
4.17Single7SRQLSD7SRQ-5-HT2B-LSD
4.17Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
4.17Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
4.17Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
4.17Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
4.17Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
4.17Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
4.17Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
4.17Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
4.17Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
4.17Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
4.17Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
4.17Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.17Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.17Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
4.17Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
4.17Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
4.17Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
4.17Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
4.17Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
4.17Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
4.17Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
4.17Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
4.17Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
4.17Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
4.17Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
4.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
4.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
4.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
4.00Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
4.00Single4XNVBPTU4XNV-P2Y1-BPTU
4.00Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
4.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
4.00Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
4.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
4.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
4.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
4.00Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
4.00Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
4.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
4.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
4.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
4.00Single7F8ULintitript7F8U-CCKA-Lintitript
4.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
4.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
4.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
4.00Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
4.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
4.00Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
4.00Single7WV9ZCZ0117WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
4.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
4.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
4.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
4.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
4.00Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
4.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
4.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
4.00Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
4.00Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
4.00Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
4.00Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
4.00Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
4.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
4.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
4.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
4.00Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
4.00Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
4.00Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
4.00Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
4.00Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
4.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
4.00Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
4.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
4.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
4.00Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
4.00Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
4.00Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
4.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
4.00Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
3.85Single3RZECidoxepin3RZE-H1-Cidoxepin
3.85Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
3.85Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
3.85Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
3.85Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
3.85Single5IU7Q274563465IU7-A2A-Q27456346-Na
3.85Single5IUBQ274563445IUB-A2A-Q27456344-Na
3.85Single5JTBZM-2413855JTB-A2A-ZM-241385
3.85Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
3.85Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
3.85Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
3.85Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
3.85Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
3.85Single5UVIZM-2413855UVI-A2A-ZM-241385
3.85Single6AQFZM-2413856AQF-A2A-ZM-241385
3.85Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
3.85Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
3.85Single6MH8ZM-2413856MH8-A2A-ZM-241385
3.85Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
3.85Single6VI4JDTic6VI4-κ-JDTic
3.85Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
3.85Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
3.85Single6ZINSR486926ZIN-NTS1-SR48692
3.85Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
3.85Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
3.85Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
3.85Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
3.85Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
3.85Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
3.85Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
3.85Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
3.85Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
3.85Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
3.85Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.85Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85Single7T32ZM-2413857T32-A2A-ZM-241385
3.85Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
3.85Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
3.85Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
3.85Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
3.85Single7VV6C48/807VV6-MRGPRX2-C48/80
3.85Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
3.85Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
3.85Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
3.85Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
3.85Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.85Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
3.85Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
3.85Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
3.85Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
3.85Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
3.85Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
3.85Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
3.85Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
3.85Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
3.85Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
3.85Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
3.85Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
3.85Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
3.85Consensusa2_offOrthosteric Liganda2a_off
3.85Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
3.85Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
3.85Consensusalpha1_onOrthosteric Ligandalpha1a_on
3.85Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
3.85Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
3.85Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
3.85Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
3.85Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
3.85Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
3.85Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
3.70Single3EMLZM-2413853EML-A2A-ZM-241385
3.70Single4DAJTiotropium4DAJ-M3-Tiotropium
3.70Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
3.70Single4EJ4Naltrindole4EJ4-δ-Naltrindole
3.70Single4MQSIperoxo4MQS-M2-Iperoxo
3.70Single4QIMANTA XV4QIM-SMO-ANTA XV
3.70Single4U14Tiotropium4U14-M3-Tiotropium
3.70Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
3.70Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
3.70Single5IU8Q274563475IU8-A2A-Q27456347-Na
3.70Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
3.70Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
3.70Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
3.70Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
3.70Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
3.70Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
3.70Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
3.70Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
3.70Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
3.70Single6S0LZM-2413856S0L-A2A-ZM-241385
3.70Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.70Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
3.70Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
3.70Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
3.70Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
3.70Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
3.70Single7PYRPSB-21157PYR-A2A-PSB-2115
3.70Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
3.70Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
3.70Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
3.70Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
3.70Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
3.70Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.70Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
3.70Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
3.70Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
3.70Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
3.70Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
3.70Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
3.70Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
3.70Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
3.70Single8X63Mepyramine8X63-H1-Mepyramine
3.70Single8X64Desloratadine8X64-H1-Desloratadine
3.70Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
3.70Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
3.70Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
3.70Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
3.70Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
3.70Consensusa3_onOrthosteric Liganda3a_on
3.70Consensusalpha2_onOrthosteric Ligandalpha2b_on
3.70Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
3.70Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
3.70Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
3.70Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
3.70Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
3.70Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
3.70Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
3.70Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
3.70Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
3.70Consensushistamine_offOrthosteric Ligandh1_off
3.70Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
3.70Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
3.57Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
3.57Single5CGCHTL142425CGC-mGlu5-HTL14242
3.57Single5IUAQ274563485IUA-A2A-Q27456348-Na
3.57Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
3.57Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
3.57Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
3.57Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
3.57Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
3.57Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
3.57Single6S0QZM-2413856S0Q-A2A-ZM-241385
3.57Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
3.57Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
3.57Single6Z4SSR486926Z4S-NTS1-SR48692
3.57Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
3.57Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
3.57Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
3.57Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
3.57Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
3.57Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
3.57Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.57Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.57Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.57Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
3.57Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
3.57Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
3.57Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
3.57Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
3.57Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
3.57Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
3.57Consensusa3_on_gpOrthosteric Liganda3a_on_gp
3.57Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
3.57Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
3.57Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
3.57Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
3.57Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
3.57Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
3.57Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
3.57Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
3.57Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.57Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.57Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
3.45Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
3.45Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
3.45Single4U15Tiotropium4U15-M3-Tiotropium
3.45Single5TZRMK86665TZR-FFA1-MK8666
3.45Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
3.45Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
3.45Single6OL9Tiotropium6OL9-M5-Tiotropium
3.45Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
3.45Single7PX4PSB-21137PX4-A2A-PSB-2113
3.45Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
3.45Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
3.45Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
3.45Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
3.45Single8EA0Iperoxo8EA0-M3-Iperoxo
3.45Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
3.45Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
3.45Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
3.45Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
3.45Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
3.45Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
3.45Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
3.45Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
3.45Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
3.45Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
3.45Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
3.45Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
3.45Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
3.45Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
3.45Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
3.45Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
3.45Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
3.45Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
3.33Single4N4WSANT-14N4W-SMO-SANT-1
3.33Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
3.33Single4PY02MeSATP4PY0-P2Y12-2MeSATP
3.33Single5CXVTiotropium5CXV-M1-Tiotropium
3.33Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
3.33Single6CM4Risperidone6CM4-D2-Risperidone
3.33Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
3.33Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
3.33Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
3.33Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.33Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.33Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
3.33Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
3.33Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
3.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
3.33Single8XWACXCL18XWA-CXCR2-CXCL1
3.33Single8XWSCXCL58XWS-CXCR2-CXCL5
3.33Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
3.33Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
3.33Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
3.33Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
3.33Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
3.33Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
3.33Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
3.33Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
3.23Single5CGDHTL142425CGD-mGlu5-HTL14242
3.23Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
3.23Single7EZCUKA7EZC-A2A-UKA
3.23Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
3.23Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.23Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
3.23Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
3.23Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
3.23Single8XVJMacitentan8XVJ-ETA-Macitentan
3.23Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
3.23Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
3.23Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12Single5WF6UK-4320975WF6-A2A-UK-432097
3.12Single6PT3DPI-2876PT3-δ-DPI-287
3.12Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
3.12Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
3.03Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
3.03Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.03Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
3.03Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
3.03Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.86Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.86Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.78Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.56Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

PDB Summary
PDB 6X19
Class B1
SubFamily Peptide
Type Glucagon
SubType GLP-1
Species Homo Sapiens
Ligand CHU-128
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 2.1
Date 2020-09-09
D.O.I. 10.1016/j.molcel.2020.09.020
Net Summary
Imin 3.13
Number of Linked Nodes 1088
Number of Links 1347
Number of Hubs 225
Number of Links mediated by Hubs 817
Number of Communities 31
Number of Nodes involved in Communities 318
Number of Links involved in Communities 474
Path Summary
Number Of Nodes in MetaPath 131
Number Of Links MetaPath 130
Number of Shortest Paths 2333850
Length Of Smallest Path 3
Average Path Length 34.1201
Length of Longest Path 68
Minimum Path Strength 1.26
Average Path Strength 7.48081
Maximum Path Strength 24.28
Minimum Path Correlation 0.7
Average Path Correlation 0.992584
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.5641
Average % Of Corr. Nodes 56.0731
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.2736
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • glucagon receptor activity   • peptide receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • signaling receptor activity   • transmembrane signaling receptor activity   • amide binding   • peptide hormone binding   • hormone binding   • glucagon-like peptide 1 receptor activity   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • heart process   • regulation of heart contraction   • regulation of system process   • circulatory system process   • regulation of blood circulation   • regulation of multicellular organismal process   • heart contraction   • blood circulation   • regulation of blood pressure   • positive regulation of blood pressure   • response to stress   • response to psychosocial stress   • cell surface receptor signaling pathway   • behavior   • learning or memory   • cognition   • transport   • secretion   • regulation of hormone levels   • export from cell   • hormone secretion   • establishment of localization   • localization   • secretion by cell   • signal release   • hormone transport   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • protein localization   • establishment of protein localization   • cellular localization   • nitrogen compound transport   • protein targeting   • protein transmembrane transport   • cellular macromolecule localization   • establishment of localization in cell   • post-translational protein targeting to membrane, translocation   • establishment of protein localization to endoplasmic reticulum   • protein localization to endoplasmic reticulum   • establishment of protein localization to membrane   • intracellular protein transmembrane transport   • intracellular transport   • post-translational protein targeting to endoplasmic reticulum membrane   • localization within membrane   • protein localization to membrane   • protein targeting to membrane   • transmembrane transport   • establishment of protein localization to organelle   • protein transport   • macromolecule localization   • protein localization to organelle   • intracellular protein transport   • protein targeting to ER   • negative regulation of blood pressure
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • FnI-like domain   • G protein-coupled receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • FnI-like domain   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeUK1
PDB ResiduesL:L:?99
Environment DetailsOpen EMBL-EBI Page
CodeUK1
Name3-{(1S)-1-[5-(2,2-dimethylmorpholin-4-yl)-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl]butyl}-1,2,4-oxadiazol-5(4H)-one
Synonyms
Identifier
FormulaC47 H49 F2 N11 O5
Molecular Weight885.959
SMILES
PubChem154584718
Formal Charge0
Total Atoms114
Total Chiral Atoms2
Total Bonds123
Total Aromatic Bonds31

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>6X19_Chain_A
QRNEEKAQR EANKKIEKQ LQKDKQVYR ATHRLLLLG AGESGKNTI 
VKQMRILHK ATKVQDIKN NLKEAIETI VAAMSNLVP PVELANPEN 
QFRVDYILS VMNVPDFDF PPEFYEHAK ALWEDEGVR ACYERSNEY 
QLIDCAQYF LDKIDVIKQ ADYVPSDQD LLRCRVLTS GIFETKFQV 
DKVNFHMFD VGAQRDERR KWIQCFNDV TAIIFVVAS SSYNRLQAA 
LKLFDSIWN NKWLRDTSV ILFLNKQDL LAEKVLAGK SKIEDYFPE 
FARYTTPED ATPEPGEDP RVTRAKYFI RDEFLRIST ASGDGRHYC 
YPHFTCAVD TENIRRVFN DCRDIIQRM HLRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>6X19_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>6X19_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP43220
Sequence
>6X19_Chain_R
TVSLWETVQ KWREYRRQC QRSLTEDPP PATDLFCNR TFDEYACWP 
DGEPGSFVN VSCPWYLPW ASSVPQGHV YRFCTAEGL WLQKDNSSL 
PWRDLSECE ESSSPEEQL LFLYIIYTV GYALSFSAL VIASAILLG 
FRHLHCTRN YIHLNLFAS FILRALSVF IKDAALKWM YSTAAQQHQ 
WDGLLSYQD SLSCRLVFL LMQYCVAAN YYWLLVEGV YLYTLLAFS 
VFSEQWIFR LYVSIGWGV PLLFVVPWG IVKYLYEDE GCWTRNSNM 
NYWLIIRLP ILFAIGVNF LIFVRVICI VVSKLKANL MCKTDIKCR 
LAKSTLTLI PLLGTHEVI FAFVMDEHT LRFIKLFTE LSFTSFQGL 
MVAILYCFV NNEVQLEFR KSWERWRLE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9IVMB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN3318839chim(NtGi1-Gs)/β2/γ23.222024-11-1310.1016/j.apsb.2024.09.002
9IVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN33188393.222024-11-1310.1016/j.apsb.2024.09.002
8YW3B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-Gs/β1/γ22.682024-09-18doi.org/10.1038/s41421-024-00700-0
8YW3 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-2.682024-09-18doi.org/10.1038/s41421-024-00700-0
8WG7B1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.542024-03-0610.1038/s41421-024-00649-0
8WG7 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.542024-03-0610.1038/s41421-024-00649-0
8JISB1PeptideGlucagonGLP-1Homo sapiensPeptide-15-chim(NtGi1-Gs)/β1/γ22.462023-11-0810.1073/pnas.2303696120
8JIS (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-15-2.462023-11-0810.1073/pnas.2303696120
8JIRB1PeptideGlucagonGLP-1Homo sapiensSAR425899-chim(NtGi1-Gs)/β1/γ22.572023-09-0610.1073/pnas.2303696120
8JIR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSAR425899-2.572023-09-0610.1073/pnas.2303696120
8JIPB1PeptideGlucagonGLP-1Homo sapiensMEDI0382-chim(NtGi1-Gs)/β1/γ22.852023-09-0610.1073/pnas.2303696120
8JIP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensMEDI0382-2.852023-09-0610.1073/pnas.2303696120
9IVGB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ232024-11-2710.1016/j.apsb.2024.09.002
9IVG (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-32024-11-2710.1016/j.apsb.2024.09.002
9J1PB1PeptideGlucagonGLP-1Homo sapiensg1:Ox-chim(NtGi1-Gs)/β1/γ22.992025-02-2610.1021/jacs.4c12808
9J1P (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensg1:Ox-2.992025-02-2610.1021/jacs.4c12808
7X8SB1PeptideGlucagonGLP-1Homo sapiensWB4-24-Gs/β1/γ23.092022-06-2910.1073/pnas.2200155119
7X8S (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensWB4-24-3.092022-06-2910.1073/pnas.2200155119
7X8RB1PeptideGlucagonGLP-1Homo sapiensBOC5-Gs/β1/γ22.612022-06-2910.1073/pnas.2200155119
7X8R (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensBOC5-2.612022-06-2910.1073/pnas.2200155119
7S15B1PeptideGlucagonGLP-1Homo sapiensPubChem 134611223--3.82022-06-0810.1021/acs.jmedchem.1c01856
7RGPB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-chim(NtGi1-Gs)/β1/γ22.92022-04-1310.1073/pnas.2116506119
7RGP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-2.92022-04-1310.1073/pnas.2116506119
7RG9B1PeptideGlucagonGLP-1Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22022-04-1310.1073/pnas.2116506119
7RG9 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.22022-04-1310.1073/pnas.2116506119
7VBHB1PeptideGlucagonGLP-1Homo sapiensPeptide-20-Gs/β1/γ232022-04-0610.1038/s41467-022-28683-0
7VBH (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-20-32022-04-0610.1038/s41467-022-28683-0
7VBIB1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-Gs/β1/γ232022-03-0210.1038/s41467-022-28683-0
7VBI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-32022-03-0210.1038/s41467-022-28683-0
7FIMB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-Gs/β1/γ23.42022-03-0210.1038/s41467-022-28683-0
7FIM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-3.42022-03-0210.1038/s41467-022-28683-0
7LLYB1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-Gs/β1/γ23.32022-01-1210.1038/s41467-021-27760-0
7LLY (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-3.32022-01-1210.1038/s41467-021-27760-0
7LLLB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/β1/γ23.72022-01-1210.1038/s41467-021-27760-0
7LLL (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-4-3.72022-01-1210.1038/s41467-021-27760-0
7S3IB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.512022-01-0510.1038/s41589-021-00945-w
7S3I (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.512022-01-0510.1038/s41589-021-00945-w
7S1MB1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-Gs/β1/γ22.412022-01-0510.1038/s41589-021-00945-w
7S1M (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-2.412022-01-0510.1038/s41589-021-00945-w
7RTBB1PeptideGlucagonGLP-1Homo sapiensPeptide-19-Gs/β1/γ22.142021-10-0610.1016/j.bbrc.2021.09.016
7RTB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-19-2.142021-10-0610.1016/j.bbrc.2021.09.016
7EVMB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ22.52021-08-1110.1038/s41467-021-24058-z
7EVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227382.52021-08-1110.1038/s41467-021-24058-z
7DURB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ23.32021-08-1110.1038/s41467-021-24058-z
7DUR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227383.32021-08-1110.1038/s41467-021-24058-z
7KI1B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-Gs/β1/γ22.52021-08-0410.1016/j.celrep.2021.109374
7KI1 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-2.52021-08-0410.1016/j.celrep.2021.109374
7KI0B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-Gs/β1/γ22.52021-08-0410.1016/j.celrep.2021.109374
7KI0 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-2.52021-08-0410.1016/j.celrep.2021.109374
7DUQB1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 156022738Gs/β1/γ22.52021-07-1410.1038/s41467-021-24058-z
7DUQ (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 1560227382.52021-07-1410.1038/s41467-021-24058-z
7E14B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 156022738Gs/β1/γ22.92021-07-0710.1038/s41467-021-24058-z
7E14 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 1560227382.92021-07-0710.1038/s41467-021-24058-z
7LCKB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--3.242021-01-2010.1016/j.str.2021.04.008
7LCJB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--2.822021-01-2010.1016/j.str.2021.04.008
7LCIB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.92021-01-2010.1016/j.str.2021.04.008
7LCI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.92021-01-2010.1016/j.str.2021.04.008
6XOXB1PeptideGlucagonGLP-1Homo sapiensOrforglipron-chim(NtGi1-Gs)/β1/γ23.12020-11-1810.1073/pnas.2014879117
6XOX (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipron-3.12020-11-1810.1073/pnas.2014879117
6X1AB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.52020-09-0910.1016/j.molcel.2020.09.020
6X1A (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.52020-09-0910.1016/j.molcel.2020.09.020
6X19B1PeptideGlucagonGLP-1Homo sapiensCHU-128-Gs/β1/γ22.12020-09-0910.1016/j.molcel.2020.09.020
6X19 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensCHU-128-2.12020-09-0910.1016/j.molcel.2020.09.020
6X18B1PeptideGlucagonGLP-1Homo sapiensGLP-1-Gs/β1/γ22.12020-09-0910.1016/j.molcel.2020.09.020
6X18 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1-2.12020-09-0910.1016/j.molcel.2020.09.020
7C2EB1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-Gs/β1/γ24.22020-08-2610.1038/s41422-020-0384-8
7C2E (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-4.22020-08-2610.1038/s41422-020-0384-8
6VCBB1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN3160440Gs/β1/γ23.32020-07-2210.1038/s41589-020-0589-7
6VCB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN31604403.32020-07-2210.1038/s41589-020-0589-7
6LN2B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-3.22020-03-1810.1038/s41467-020-14934-5
6ORVB1PeptideGlucagonGLP-1Homo sapiens-TT-OAD2Gs/β1/γ232020-01-0810.1038/s41586-019-1902-z
6ORV (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-TT-OAD232020-01-0810.1038/s41586-019-1902-z
6KK7B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-3.12019-11-1310.1107/S2052252519013496
6KK1B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-2.82019-11-1310.1107/S2052252519013496
6KJVB1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-2.82019-11-1310.1107/S2052252519013496
6B3JB1PeptideGlucagonGLP-1Homo sapiensExendin-P5-Gs/β1/γ23.32018-02-2110.1038/nature25773
6B3J (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-P5-3.32018-02-2110.1038/nature25773
5NX2B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)--3.72017-06-1410.1038/nature22800
5VEWB1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.72017-05-2410.1038/nature22378
5VAIB1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-Gs/β1/γ24.12017-05-2410.1038/nature22394
5VAI (No Gprot) B1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-4.12017-05-2410.1038/nature22394
5VEXB1PeptideGlucagonGLP-1Homo sapiens-NNC0640-32017-05-1710.1038/nature22378




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