psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?2	L:L:Y1	6.74	Yes	Yes	1	0	0
2	L:L:E3	L:L:Y1	3.37	Yes	Yes	1	0	0
3	L:L:G4	L:L:Y1	5.79	No	Yes	1	0	0
4	L:L:Y1	R:R:Q234	11.27	Yes	Yes	1	0	7
5	L:L:Y1	R:R:V237	8.83	Yes	No	0	0	6
6	L:L:Y1	R:R:W306	5.79	Yes	Yes	1	0	6
7	L:L:?2	L:L:E3	11.42	Yes	Yes	1	0	0
8	L:L:?2	L:L:G4	3.28	Yes	No	1	0	0
9	L:L:?2	L:L:T5	4.23	Yes	No	1	0	0
10	L:L:?2	R:R:E387	6.34	Yes	No	1	0	8
11	L:L:?2	R:R:L388	3.98	Yes	Yes	1	0	7
12	L:L:E3	R:R:Y152	8.98	Yes	Yes	1	0	7
13	L:L:E3	R:R:R190	8.14	Yes	Yes	1	0	8
14	L:L:E3	R:R:L388	3.98	Yes	Yes	1	0	7
15	L:L:T5	R:R:W306	4.85	No	Yes	1	0	6
16	L:L:T5	R:R:D372	14.45	No	Yes	1	0	5
17	L:L:F6	L:L:Y10	5.16	Yes	No	1	0	0
18	L:L:F6	R:R:L141	6.09	Yes	No	1	0	5
19	L:L:F6	R:R:L144	4.87	Yes	Yes	1	0	6
20	L:L:F6	R:R:Y148	8.25	Yes	Yes	1	0	7
21	L:L:F6	R:R:L388	3.65	Yes	Yes	1	0	7
22	L:L:T7	R:R:K197	10.51	No	Yes	0	0	6
23	L:L:S8	R:R:N300	7.45	No	No	0	0	6
24	L:L:D9	R:R:R380	11.91	No	No	0	0	5
25	L:L:L14	L:L:Y10	12.89	No	No	0	0	0
26	L:L:Y10	R:R:L141	4.69	No	No	1	0	5
27	L:L:S11	R:R:Y205	3.82	No	Yes	0	0	3
28	L:L:S11	R:R:T298	6.4	No	Yes	3	0	5
29	L:L:S11	R:R:R299	5.27	No	Yes	3	0	4
30	L:L:I12	R:R:R299	3.76	No	Yes	0	0	4
31	L:L:?13	L:L:L14	5.3	No	No	0	0	0
32	L:L:?13	L:L:K16	5.4	No	No	0	0	0
33	L:L:?13	L:L:I17	6.83	No	No	0	0	0
34	L:L:L14	R:R:Y205	8.21	No	Yes	0	0	3
35	L:L:D15	L:L:Q19	5.22	No	Yes	0	0	0
36	L:L:D15	R:R:Y205	9.2	No	Yes	0	0	3
37	L:L:D15	R:R:R299	4.76	No	Yes	0	0	4
38	L:L:K16	L:L:K20	7.18	No	No	0	0	0
39	L:L:K16	R:R:W91	3.48	No	Yes	0	0	4
40	L:L:A18	R:R:Q210	6.06	No	No	0	0	4
41	L:L:Q19	R:R:V30	4.3	Yes	No	0	0	2
42	L:L:Q19	R:R:T35	5.67	Yes	No	0	0	5
43	L:L:Q19	R:R:P90	9.47	Yes	No	0	0	4
44	L:L:F22	L:L:L26	9.74	Yes	No	2	0	0
45	L:L:F22	R:R:W39	5.01	Yes	Yes	2	0	5
46	L:L:F22	R:R:W214	9.02	Yes	Yes	0	0	1
47	L:L:W25	R:R:E68	5.45	No	No	0	0	4
48	L:L:W25	R:R:W214	27.18	No	Yes	0	0	1
49	L:L:L26	R:R:W39	7.97	No	Yes	2	0	5
50	L:L:L26	R:R:Y88	4.69	No	Yes	2	0	5
51	L:L:I27	R:R:Y69	3.63	No	No	0	0	6
52	L:L:G29	R:R:E68	4.91	No	No	0	0	4
53	R:R:S301	R:R:T29	6.4	No	No	0	3	2
54	R:R:L32	R:R:Q213	5.32	No	No	0	4	4
55	R:R:Q37	R:R:W33	14.24	No	No	0	4	3
56	R:R:E34	R:R:K38	5.4	No	No	0	4	4
57	R:R:Q37	R:R:R40	4.67	No	Yes	0	4	2
58	R:R:K38	R:R:W87	4.64	No	No	0	4	3
59	R:R:R43	R:R:W39	7	No	Yes	0	4	5
60	R:R:W39	R:R:Y88	8.68	Yes	Yes	2	5	5
61	R:R:R40	R:R:R44	7.46	Yes	No	0	2	3
62	R:R:G216	R:R:R40	4.5	No	Yes	0	2	2
63	R:R:E41	R:R:W87	4.36	No	No	0	4	3
64	R:R:C46	R:R:Y42	9.41	No	Yes	2	8	6
65	R:R:C71	R:R:Y42	4.03	No	Yes	2	9	6
66	R:R:P86	R:R:Y42	8.34	No	Yes	2	8	6
67	R:R:W87	R:R:Y42	10.61	No	Yes	0	3	6
68	R:R:Y42	R:R:Y88	3.97	Yes	Yes	2	6	5
69	R:R:Q47	R:R:R43	5.84	No	No	0	3	4
70	R:R:F66	R:R:R43	11.76	No	No	0	7	4
71	R:R:C46	R:R:C71	7.28	No	No	2	8	9
72	R:R:E52	R:R:R48	8.14	No	No	0	2	4
73	R:R:L50	R:R:R64	8.5	No	No	0	4	4
74	R:R:D53	R:R:P55	6.44	No	No	0	3	1
75	R:R:P54	R:R:P56	3.9	No	No	0	2	1
76	R:R:D74	R:R:P55	12.88	Yes	No	0	3	1
77	R:R:D74	R:R:P56	3.22	Yes	No	0	3	1
78	R:R:D59	R:R:T58	4.34	No	No	4	3	1
79	R:R:F61	R:R:T58	15.56	Yes	No	4	3	1
80	R:R:P77	R:R:T58	8.74	No	No	4	4	1
81	R:R:D59	R:R:F61	7.17	No	Yes	4	3	3
82	R:R:F61	R:R:P77	8.67	Yes	No	4	3	4
83	R:R:F61	R:R:G108	4.52	Yes	No	0	3	9
84	R:R:C104	R:R:C62	7.28	No	No	5	9	9
85	R:R:C62	R:R:W110	6.53	No	Yes	5	9	9
86	R:R:D74	R:R:N63	8.08	Yes	No	0	3	4
87	R:R:D74	R:R:R64	4.76	Yes	No	0	3	4
88	R:R:T65	R:R:W72	4.85	No	Yes	0	5	9
89	R:R:D67	R:R:W72	4.47	No	Yes	0	9	9
90	R:R:D67	R:R:R121	4.76	No	No	0	9	6
91	R:R:Y69	R:R:Y88	7.94	No	Yes	0	6	5
92	R:R:A70	R:R:R102	4.15	No	Yes	0	5	8
93	R:R:R102	R:R:W72	19.99	Yes	Yes	0	8	9
94	R:R:W110	R:R:W72	10.31	Yes	Yes	0	9	9
95	R:R:E76	R:R:P77	4.72	No	No	0	1	4
96	R:R:S79	R:R:V81	3.23	No	No	0	5	6
97	R:R:F80	R:R:Y101	4.13	No	No	0	4	5
98	R:R:F103	R:R:F80	18.22	Yes	No	0	4	4
99	R:R:H99	R:R:N82	14.03	No	No	0	4	4
100	R:R:N82	R:R:Y101	4.65	No	No	0	4	5
101	R:R:R102	R:R:V83	11.77	Yes	No	0	8	5
102	R:R:H99	R:R:S84	4.18	No	No	0	4	4
103	R:R:C85	R:R:G98	3.92	No	No	0	9	4
104	R:R:C126	R:R:C85	7.28	No	No	0	9	9
105	R:R:P86	R:R:Y88	8.34	No	Yes	2	8	5
106	R:R:L89	R:R:Y88	8.21	Yes	Yes	2	5	5
107	R:R:L89	R:R:P90	3.28	Yes	No	2	5	4
108	R:R:L89	R:R:W91	5.69	Yes	Yes	2	5	4
109	R:R:P90	R:R:W91	14.86	No	Yes	2	4	4
110	R:R:S94	R:R:W91	3.71	No	Yes	0	4	4
111	R:R:E128	R:R:W91	9.81	No	Yes	0	3	4
112	R:R:S94	R:R:V95	4.85	No	No	0	4	5
113	R:R:E125	R:R:G98	4.91	No	No	0	5	4
114	R:R:R102	R:R:V100	10.46	Yes	No	0	8	7
115	R:R:F103	R:R:T105	12.97	Yes	No	0	4	4
116	R:R:F103	R:R:L111	15.83	Yes	No	6	4	4
117	R:R:F103	R:R:W120	11.02	Yes	Yes	6	4	5
118	R:R:C104	R:R:W110	15.67	No	Yes	5	9	9
119	R:R:E107	R:R:T105	8.47	No	No	0	5	4
120	R:R:L109	R:R:W110	3.42	No	Yes	0	5	9
121	R:R:P119	R:R:W110	12.16	No	Yes	0	6	9
122	R:R:L111	R:R:W120	10.25	No	Yes	6	4	5
123	R:R:K113	R:R:L118	16.92	No	No	0	4	4
124	R:R:K113	R:R:W120	8.12	No	Yes	0	4	5
125	R:R:D122	R:R:W120	3.35	No	Yes	0	7	5
126	R:R:L123	R:R:R121	14.58	No	No	0	5	6
127	R:R:F381	R:R:Q140	5.86	No	No	0	4	4
128	R:R:F143	R:R:I147	5.02	No	No	0	4	6
129	R:R:F143	R:R:F385	5.36	No	Yes	0	4	6
130	R:R:F381	R:R:L144	4.87	No	Yes	1	4	6
131	R:R:L144	R:R:L384	4.15	Yes	No	0	6	5
132	R:R:F385	R:R:L144	3.65	Yes	Yes	1	6	6
133	R:R:T149	R:R:Y145	4.99	No	No	0	7	5
134	R:R:D198	R:R:Y145	6.9	No	No	0	7	5
135	R:R:Y148	R:R:Y152	4.96	Yes	Yes	1	7	7
136	R:R:K197	R:R:Y148	4.78	Yes	Yes	1	6	7
137	R:R:D198	R:R:Y148	9.2	No	Yes	1	7	7
138	R:R:L388	R:R:Y148	3.52	Yes	Yes	1	7	7
139	R:R:F393	R:R:G151	9.03	No	No	0	7	8
140	R:R:R190	R:R:Y152	7.2	Yes	Yes	1	8	7
141	R:R:A191	R:R:Y152	5.34	No	Yes	0	7	7
142	R:R:V194	R:R:Y152	11.36	No	Yes	0	7	7
143	R:R:S392	R:R:Y152	16.53	No	Yes	0	9	7
144	R:R:F156	R:R:V160	3.93	No	No	0	7	3
145	R:R:F156	R:R:I188	3.77	No	No	0	7	7
146	R:R:F156	R:R:L192	4.87	No	No	0	7	3
147	R:R:F184	R:R:L159	6.09	No	Yes	0	8	9
148	R:R:F187	R:R:L159	3.65	Yes	Yes	0	8	9
149	R:R:F404	R:R:I161	3.77	No	No	0	8	4
150	R:R:A162	R:R:C403	3.61	No	No	0	9	9
151	R:R:F184	R:R:S163	3.96	No	No	0	8	6
152	R:R:C403	R:R:I165	3.27	No	No	0	9	8
153	R:R:F413	R:R:I165	6.28	No	No	0	5	8
154	R:R:L166	R:R:N177	4.12	Yes	No	0	8	9
155	R:R:L166	R:R:L181	6.92	Yes	No	0	8	6
156	R:R:F184	R:R:L166	4.87	No	Yes	0	8	8
157	R:R:C403	R:R:L166	3.17	No	Yes	0	9	8
158	R:R:L167	R:R:L181	4.15	No	No	0	3	6
159	R:R:F169	R:R:L172	3.65	No	No	0	7	9
160	R:R:F169	R:R:F413	6.43	No	No	0	7	5
161	R:R:H173	R:R:R170	6.77	No	No	0	7	8
162	R:R:E412	R:R:H171	12.31	No	No	0	8	7
163	R:R:L172	R:R:V409	4.47	No	No	0	9	9
164	R:R:E412	R:R:L172	3.98	No	No	0	8	9
165	R:R:H173	R:R:Y178	7.62	No	No	0	7	6
166	R:R:C174	R:R:N177	4.72	No	No	0	8	9
167	R:R:T175	R:R:Y250	4.99	No	Yes	0	7	8
168	R:R:E262	R:R:T175	9.88	No	No	0	6	7
169	R:R:N177	R:R:R176	4.82	No	No	0	9	9
170	R:R:H180	R:R:R176	5.64	No	No	0	9	9
171	R:R:R176	R:R:Y250	4.12	No	Yes	0	9	8
172	R:R:E247	R:R:I179	5.47	Yes	No	0	9	8
173	R:R:I179	R:R:Y250	8.46	No	Yes	0	8	8
174	R:R:E247	R:R:H180	11.08	Yes	No	0	9	9
175	R:R:H180	R:R:Y402	4.36	No	Yes	0	9	8
176	R:R:N182	R:R:W243	15.82	No	Yes	7	9	9
177	R:R:N182	R:R:W274	5.65	No	Yes	7	9	9
178	R:R:F187	R:R:L183	7.31	Yes	No	0	8	9
179	R:R:L183	R:R:L244	4.15	No	No	0	9	9
180	R:R:E247	R:R:L183	6.63	Yes	No	0	9	9
181	R:R:N240	R:R:S186	7.45	No	No	0	9	9
182	R:R:S186	R:R:W243	7.41	No	Yes	0	9	9
183	R:R:F187	R:R:N240	12.08	Yes	No	0	8	9
184	R:R:F187	R:R:Q394	7.03	Yes	Yes	0	8	9
185	R:R:F187	R:R:G395	9.03	Yes	No	0	8	9
186	R:R:F187	R:R:V398	3.93	Yes	No	0	8	9
187	R:R:C236	R:R:L189	6.35	No	No	0	5	7
188	R:R:R190	R:R:V237	10.46	Yes	No	0	8	6
189	R:R:N240	R:R:R190	9.64	No	Yes	0	9	8
190	R:R:R190	R:R:Y241	9.26	Yes	Yes	1	8	8
191	R:R:R190	R:R:T391	5.17	Yes	No	0	8	6
192	R:R:C236	R:R:S193	5.16	No	No	0	5	6
193	R:R:D198	R:R:K197	12.44	No	Yes	1	7	6
194	R:R:F230	R:R:K197	4.96	Yes	Yes	0	5	6
195	R:R:K197	R:R:M233	8.64	Yes	No	0	6	6
196	R:R:F230	R:R:L201	3.65	Yes	No	0	5	7
197	R:R:W203	R:R:Y220	3.86	No	No	0	3	3
198	R:R:M204	R:R:Y205	7.18	Yes	Yes	0	3	3
199	R:R:M204	R:R:Q221	6.8	Yes	No	0	3	4
200	R:R:C226	R:R:M204	3.24	No	Yes	3	9	3
201	R:R:C296	R:R:M204	8.1	No	Yes	3	9	3
202	R:R:M204	R:R:T298	4.52	Yes	Yes	3	3	5
203	R:R:A209	R:R:S206	3.42	No	No	0	1	4
204	R:R:Q210	R:R:W214	6.57	No	Yes	0	4	1
205	R:R:Q211	R:R:W214	6.57	No	Yes	0	4	1
206	R:R:D215	R:R:Q211	5.22	No	No	0	3	4
207	R:R:H212	R:R:L217	7.71	No	No	0	3	4
208	R:R:Q213	R:R:S219	8.66	No	No	0	4	5
209	R:R:Q213	R:R:Q221	6.4	No	No	0	4	4
210	R:R:C226	R:R:Y220	9.41	No	No	0	9	3
211	R:R:D222	R:R:R227	3.57	No	No	0	6	8
212	R:R:L224	R:R:L228	4.15	No	No	0	3	4
213	R:R:C226	R:R:C296	7.28	No	No	3	9	9
214	R:R:D293	R:R:R227	9.53	No	No	8	7	8
215	R:R:R227	R:R:W297	19.99	No	Yes	8	8	8
216	R:R:F230	R:R:T298	7.78	Yes	Yes	0	5	5
217	R:R:L231	R:R:W297	5.69	No	Yes	0	5	8
218	R:R:C236	R:R:L232	3.17	No	No	0	5	5
219	R:R:M233	R:R:Q234	4.08	No	Yes	0	6	7
220	R:R:Q234	R:R:W284	12.05	Yes	Yes	1	7	8
221	R:R:I309	R:R:Q234	5.49	No	Yes	1	7	7
222	R:R:W274	R:R:Y235	4.82	Yes	No	0	9	9
223	R:R:L278	R:R:Y235	5.86	No	No	0	3	9
224	R:R:I313	R:R:Y241	12.09	No	Yes	0	7	8
225	R:R:I317	R:R:Y241	4.84	Yes	Yes	1	7	8
226	R:R:E364	R:R:Y241	11.22	Yes	Yes	1	8	8
227	R:R:V276	R:R:Y242	7.57	No	No	0	3	6
228	R:R:F280	R:R:Y242	7.22	Yes	No	0	5	6
229	R:R:A316	R:R:Y242	4	No	No	0	7	6
230	R:R:V246	R:R:W243	6.13	No	Yes	0	8	9
231	R:R:V270	R:R:W243	4.9	No	Yes	0	5	9
232	R:R:G273	R:R:W243	8.44	No	Yes	0	9	9
233	R:R:W243	R:R:W274	19.68	Yes	Yes	7	9	9
234	R:R:L244	R:R:Q394	3.99	No	Yes	0	9	9
235	R:R:A316	R:R:L245	4.73	No	No	0	7	8
236	R:R:V246	R:R:Y269	5.05	No	Yes	0	8	7
237	R:R:E247	R:R:L359	10.6	Yes	No	0	9	9
238	R:R:V249	R:R:Y269	3.79	No	Yes	0	6	7
239	R:R:L254	R:R:Y250	12.89	No	Yes	0	8	8
240	R:R:L251	R:R:L255	4.15	No	No	0	9	8
241	R:R:L251	R:R:V327	4.47	No	No	0	9	9
242	R:R:A256	R:R:Y252	6.67	No	No	0	6	8
243	R:R:I323	R:R:Y252	3.63	No	No	0	8	8
244	R:R:F257	R:R:T253	5.19	No	No	0	5	7
245	R:R:I330	R:R:L255	4.28	No	No	0	9	8
246	R:R:I265	R:R:L260	5.71	No	No	0	5	7
247	R:R:I265	R:R:W264	3.52	No	No	0	5	5
248	R:R:F266	R:R:V270	5.24	No	No	0	6	5
249	R:R:I272	R:R:L268	4.28	Yes	No	0	6	2
250	R:R:I272	R:R:V276	4.61	Yes	No	0	6	3
251	R:R:G275	R:R:L278	3.42	No	No	0	6	3
252	R:R:P277	R:R:V276	3.53	No	No	0	9	3
253	R:R:F280	R:R:P312	20.23	Yes	No	0	5	8
254	R:R:P283	R:R:V282	3.53	No	No	0	5	3
255	R:R:K288	R:R:W284	17.4	No	Yes	0	8	8
256	R:R:I308	R:R:W284	3.52	No	Yes	0	8	8
257	R:R:I309	R:R:W284	11.74	No	Yes	1	7	8
258	R:R:V287	R:R:Y305	5.05	No	Yes	0	4	4
259	R:R:K288	R:R:W297	12.76	No	Yes	0	8	8
260	R:R:D293	R:R:Y289	4.6	No	No	0	7	3
261	R:R:L290	R:R:Y291	4.69	No	No	0	3	3
262	R:R:Y291	R:R:Y305	10.92	No	Yes	0	3	4
263	R:R:E292	R:R:S301	8.62	No	No	0	6	3
264	R:R:E292	R:R:N302	5.26	No	No	9	6	5
265	R:R:E292	R:R:Y305	3.37	No	Yes	9	6	4
266	R:R:D293	R:R:W297	4.47	No	Yes	8	7	8
267	R:R:R299	R:R:T298	3.88	Yes	Yes	3	4	5
268	R:R:M303	R:R:N300	4.21	No	No	0	5	6
269	R:R:N300	R:R:W306	14.69	No	Yes	0	6	6
270	R:R:N302	R:R:Y305	15.12	No	Yes	9	5	4
271	R:R:D372	R:R:M303	5.54	Yes	No	0	5	5
272	R:R:E373	R:R:M303	9.47	No	No	0	4	5
273	R:R:I309	R:R:W306	5.87	No	Yes	1	7	6
274	R:R:R310	R:R:W306	19.99	Yes	Yes	0	6	6
275	R:R:D372	R:R:W306	5.58	Yes	Yes	1	5	6
276	R:R:L307	R:R:R310	3.64	No	Yes	0	7	6
277	R:R:L307	R:R:L311	6.92	No	No	0	7	4
278	R:R:M371	R:R:R310	6.2	No	Yes	0	7	6
279	R:R:E373	R:R:R310	10.47	No	Yes	0	4	6
280	R:R:F369	R:R:L314	8.53	No	No	0	4	4
281	R:R:F315	R:R:V319	5.24	No	No	0	4	6
282	R:R:G318	R:R:I317	3.53	No	Yes	0	4	7
283	R:R:E364	R:R:I317	4.1	Yes	Yes	1	8	7
284	R:R:L360	R:R:N320	8.24	No	No	0	9	9
285	R:R:F321	R:R:V325	6.55	No	No	0	6	5
286	R:R:F321	R:R:V365	6.55	No	No	0	6	6
287	R:R:F324	R:R:T353	3.89	Yes	No	0	9	9
288	R:R:F324	R:R:L356	7.31	Yes	No	10	9	9
289	R:R:F324	R:R:L360	3.65	Yes	No	10	9	9
290	R:R:F324	R:R:T362	9.08	Yes	No	0	9	7
291	R:R:I328	R:R:T353	4.56	No	No	0	7	9
292	R:R:S352	R:R:V331	4.85	No	No	0	9	8
293	R:R:L335	R:R:R348	4.86	No	No	0	8	8
294	R:R:D344	R:R:I345	4.2	No	No	0	7	5
295	R:R:C347	R:R:I345	3.27	No	No	0	7	5
296	R:R:K346	R:R:L349	4.23	No	No	0	6	9
297	R:R:K351	R:R:R348	12.38	No	No	0	8	8
298	R:R:R348	R:R:S352	5.27	No	No	0	8	9
299	R:R:L356	R:R:L360	5.54	No	No	10	9	9
300	R:R:I357	R:R:P358	3.39	No	No	0	8	9
301	R:R:I357	R:R:T362	4.56	No	No	0	8	7
302	R:R:M397	R:R:P358	8.39	No	No	0	5	9
303	R:R:L401	R:R:P358	4.93	No	No	0	8	9
304	R:R:L359	R:R:Y402	17.58	No	Yes	0	9	8
305	R:R:E364	R:R:H363	18.46	Yes	Yes	1	8	8
306	R:R:F390	R:R:H363	6.79	No	Yes	0	6	8
307	R:R:H363	R:R:T391	4.11	Yes	No	0	8	6
308	R:R:H363	R:R:Q394	12.36	Yes	Yes	1	8	9
309	R:R:E364	R:R:Q394	5.1	Yes	Yes	1	8	9
310	R:R:F367	R:R:I366	5.02	Yes	No	0	7	6
311	R:R:F367	R:R:V370	3.93	Yes	No	0	7	5
312	R:R:F367	R:R:K383	8.69	Yes	No	0	7	7
313	R:R:F367	R:R:T386	10.38	Yes	No	1	7	4
314	R:R:E387	R:R:F367	5.83	No	Yes	1	8	7
315	R:R:D372	R:R:R380	9.53	Yes	No	0	5	5
316	R:R:F381	R:R:F385	4.29	No	Yes	1	4	6
317	R:R:F385	R:R:S389	5.28	Yes	No	0	6	5
318	R:R:E387	R:R:T386	5.64	No	No	1	8	4
319	R:R:F404	R:R:I400	3.77	No	No	0	8	6
320	R:R:L401	R:R:Y402	4.69	No	Yes	0	8	8
321	R:R:N406	R:R:V409	5.91	No	No	0	9	9
322	R:R:E408	R:R:N407	11.83	No	No	0	9	6
323	R:R:E412	R:R:K415	8.1	No	No	0	8	7
324	R:R:K415	R:R:R419	4.95	No	No	0	7	7
325	R:R:W417	R:R:W420	7.5	No	No	0	5	4
326	R:R:E418	R:R:R421	3.49	No	No	0	4	4
327	R:R:A399	R:R:L159	3.15	No	Yes	0	8	9
328	R:R:E76	R:R:P55	3.14	No	No	0	1	1
329	R:R:I272	R:R:S271	3.1	Yes	No	0	6	3
330	R:R:F266	R:R:Y178	3.09	No	No	0	6	6
331	R:R:R326	R:R:Y252	3.09	No	No	0	8	8
332	R:R:M233	R:R:S193	3.07	No	No	0	6	6
333	R:R:I196	R:R:V229	3.07	No	No	0	5	7
334	R:R:I272	R:R:V246	3.07	Yes	No	0	6	8
335	R:R:I317	R:R:V365	3.07	Yes	No	0	7	6
336	R:R:L118	R:R:S116	3	No	No	0	4	5
337	R:R:K351	R:R:T355	3	No	No	0	8	8
338	R:R:R414	R:R:W417	3	No	No	0	6	5
339	R:R:L245	R:R:V319	2.98	No	No	0	8	6
340	R:R:L356	R:R:V327	2.98	No	No	0	9	9
341	R:R:L349	R:R:V332	2.98	No	No	0	9	6
342	R:R:D122	R:R:S124	2.94	No	No	0	7	5
343	R:R:E34	R:R:S31	2.87	No	No	0	4	4
344	R:R:E76	R:R:S79	2.87	No	No	0	1	5
345	L:L:I27	R:R:L123	2.85	No	No	0	0	5
346	R:R:E125	R:R:V100	2.85	No	No	0	5	7
347	R:R:I146	R:R:L142	2.85	No	No	0	4	3
348	R:R:I188	R:R:L159	2.85	No	Yes	0	7	9
349	R:R:I400	R:R:L396	2.85	No	No	0	6	7
350	R:R:I323	R:R:N320	2.83	No	No	0	8	9
351	R:R:C329	R:R:R326	2.79	No	No	0	7	8
352	R:R:L154	R:R:L396	2.77	No	No	0	5	7
353	R:R:A200	R:R:F230	2.77	No	Yes	0	4	5
354	R:R:A238	R:R:F280	2.77	No	Yes	0	6	5
355	R:R:A368	R:R:F369	2.77	No	No	0	6	4
356	R:R:A375	R:R:R380	2.77	No	No	0	4	5
357	L:L:I27	L:L:Q24	2.74	No	No	0	0	0
358	R:R:A239	R:R:Y235	2.67	No	No	0	8	9
359	R:R:E138	R:R:L141	2.65	No	No	0	2	5
360	R:R:F169	R:R:S416	2.64	No	No	0	7	5
361	R:R:E408	R:R:N406	2.63	No	No	0	9	9
362	L:L:F22	R:R:V36	2.62	Yes	No	0	0	2
363	R:R:R40	R:R:V36	2.62	Yes	No	0	2	2
364	R:R:F280	R:R:V281	2.62	Yes	No	0	5	6
365	R:R:A199	R:R:W203	2.59	No	No	0	3	3
366	R:R:E41	R:R:Q45	2.55	No	No	0	4	5
367	R:R:S223	R:R:Y220	2.54	No	No	0	4	3
368	L:L:V23	R:R:Y88	2.52	No	Yes	0	0	5
369	R:R:F404	R:R:I165	2.51	No	No	0	8	8
370	R:R:T253	R:R:Y269	2.5	No	Yes	0	7	7
371	R:R:T355	R:R:Y402	2.5	No	Yes	0	8	8
372	R:R:S261	R:R:W264	2.47	No	No	0	7	5
373	R:R:E373	R:R:H374	2.46	No	No	0	4	3
374	R:R:F195	R:R:Y152	2.06	No	Yes	0	7	7
375	R:R:C62	R:R:G75	1.96	No	No	0	9	7
376	R:R:C296	R:R:G295	1.96	No	No	0	9	4
377	L:L:A28	L:L:G29	1.95	No	No	0	0	0
378	R:R:A106	R:R:G78	1.95	No	No	0	1	7
379	R:R:G75	R:R:S79	1.86	No	No	0	7	5
380	R:R:G151	R:R:S392	1.86	No	No	0	8	9
381	R:R:G395	R:R:S155	1.86	No	No	0	9	9
382	R:R:G151	R:R:V150	1.84	No	No	0	8	5
383	R:R:A158	R:R:A399	1.79	No	No	0	7	8
384	R:R:P73	R:R:V83	1.77	No	No	0	5	5
385	R:R:P96	R:R:V95	1.77	No	No	0	3	5
386	R:R:G248	R:R:I323	1.76	No	No	0	8	8
387	R:R:G285	R:R:K288	1.74	No	No	0	5	8
388	R:R:A208	R:R:S206	1.71	No	No	0	4	4
389	R:R:A209	R:R:S219	1.71	No	No	0	1	5
390	R:R:G361	R:R:L244	1.71	No	No	0	9	9
391	R:R:A200	R:R:V229	1.7	No	No	0	4	7
392	R:R:I308	R:R:P283	1.69	No	No	0	8	5
393	R:R:A28	R:R:T29	1.68	No	No	0	2	2
394	R:R:L118	R:R:P119	1.64	No	No	0	4	6
395	R:R:E294	R:R:G295	1.64	No	No	0	4	4
396	R:R:S223	R:R:S225	1.63	No	No	0	4	3
397	R:R:A368	R:R:I317	1.62	No	Yes	0	6	7
398	R:R:A350	R:R:K346	1.61	No	No	0	8	6
399	R:R:A92	R:R:L89	1.58	No	Yes	0	5	5
400	R:R:P119	R:R:Q112	1.58	No	No	0	6	3
401	R:R:I161	R:R:S157	1.55	No	No	0	4	3
402	R:R:I330	R:R:S333	1.55	No	No	0	9	7
403	R:R:I308	R:R:V287	1.54	No	No	0	8	4
404	R:R:K336	R:R:V332	1.52	No	No	0	6	6
405	R:R:L349	R:R:V331	1.49	No	No	0	9	8
406	R:R:L379	R:R:V370	1.49	No	No	0	3	5
407	R:R:L401	R:R:V405	1.49	No	No	0	8	6
408	R:R:I330	R:R:K334	1.45	No	No	0	9	9
409	R:R:I286	R:R:L290	1.43	No	No	0	4	3
410	R:R:I357	R:R:L354	1.43	No	No	0	8	8
411	R:R:K415	R:R:L411	1.41	No	No	0	7	4
412	R:R:A153	R:R:F195	1.39	No	No	0	6	7
413	R:R:H212	R:R:S219	1.39	No	No	0	3	5
414	R:R:D222	R:R:L218	1.36	No	No	0	6	3
415	R:R:E418	R:R:L422	1.33	No	No	0	4	4
416	R:R:R267	R:R:V270	1.31	No	No	0	4	5
417	R:R:A185	R:R:W274	1.3	No	Yes	0	3	9
418	R:R:E138	R:R:E139	1.27	No	No	0	2	2
419	R:R:I146	R:R:Y145	1.21	No	No	0	4	5
420	R:R:I265	R:R:Y269	1.21	No	Yes	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Y1	6.965	6	1	0
2	L:L:?2	5.99833	6	1	0
3	L:L:E3	7.178	5	1	0
4	L:L:F6	5.604	5	1	0
5	L:L:Q19	6.165	4	0	0
6	L:L:F22	6.5975	4	2	0
7	R:R:W39	7.165	4	2	5
8	R:R:R40	4.8125	4	0	2
9	R:R:Y42	7.272	5	2	6
10	R:R:F61	8.98	4	4	3
11	R:R:W72	9.905	4	0	9
12	R:R:D74	7.235	4	0	3
13	R:R:Y88	6.33571	7	2	5
14	R:R:L89	4.69	4	2	5
15	R:R:W91	7.51	5	2	4
16	R:R:R102	11.5925	4	0	8
17	R:R:F103	14.51	4	6	4
18	R:R:W110	9.618	5	5	9
19	R:R:W120	8.185	4	6	5
20	R:R:L144	4.385	4	1	6
21	R:R:Y148	6.142	5	1	7
22	R:R:Y152	8.06143	7	1	7
23	R:R:L159	3.935	4	0	9
24	R:R:L166	4.77	4	0	8
25	R:R:F187	7.17167	6	0	8
26	R:R:R190	8.31167	6	1	8
27	R:R:K197	8.266	5	1	6
28	R:R:M204	5.968	5	3	3
29	R:R:Y205	7.1025	4	0	3
30	R:R:W214	12.335	4	0	1
31	R:R:F230	4.79	4	0	5
32	R:R:Q234	8.2225	4	1	7
33	R:R:Y241	9.3525	4	1	8
34	R:R:W243	10.3967	6	7	9
35	R:R:E247	8.445	4	0	9
36	R:R:Y250	7.615	4	0	8
37	R:R:Y269	3.1375	4	0	7
38	R:R:I272	3.765	4	0	6
39	R:R:W274	7.8625	4	7	9
40	R:R:F280	8.21	4	0	5
41	R:R:W284	11.1775	4	1	8
42	R:R:W297	10.7275	4	8	8
43	R:R:T298	5.645	4	3	5
44	R:R:R299	4.4175	4	3	4
45	R:R:Y305	8.615	4	9	4
46	R:R:W306	9.46167	6	1	6
47	R:R:R310	10.075	4	0	6
48	R:R:I317	3.432	5	1	7
49	R:R:F324	5.9825	4	10	9
50	R:R:H363	10.43	4	1	8
51	R:R:E364	9.72	4	1	8
52	R:R:F367	6.77	5	1	7
53	R:R:D372	8.775	4	1	5
54	R:R:F385	4.645	4	1	6
55	R:R:L388	3.7825	4	1	7
56	R:R:Q394	7.12	4	1	9
57	R:R:Y402	7.2825	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Y1	R:R:Q234	18.3522	11.27	Yes	Yes	1	0	7
2	L:L:Y1	R:R:V237	12.5005	8.83	Yes	No	0	0	6
3	L:L:Y1	R:R:W306	12.7771	5.79	Yes	Yes	1	0	6
4	L:L:E3	R:R:R190	50.6936	8.14	Yes	Yes	1	0	8
5	L:L:F6	R:R:L388	45.4992	3.65	Yes	Yes	1	0	7
6	L:L:F6	L:L:Y10	76.9224	5.16	Yes	No	1	0	0
7	R:R:K197	R:R:Y148	12.4294	4.78	Yes	Yes	1	6	7
8	L:L:L14	L:L:Y10	76.9935	12.89	No	No	0	0	0
9	R:R:F230	R:R:K197	18.0071	4.96	Yes	Yes	0	5	6
10	R:R:F230	R:R:T298	17.0191	7.78	Yes	Yes	0	5	5
11	L:L:?13	L:L:L14	72.3037	5.3	No	No	0	0	0
12	L:L:?13	L:L:K16	71.068	5.4	No	No	0	0	0
13	L:L:D15	L:L:Q19	13.9404	5.22	No	Yes	0	0	0
14	L:L:K16	R:R:W91	69.8376	3.48	No	Yes	0	0	4
15	R:R:L89	R:R:W91	66.17	5.69	Yes	Yes	2	5	4
16	R:R:L89	R:R:Y88	75.1676	8.21	Yes	Yes	2	5	5
17	L:L:L26	R:R:Y88	13.6874	4.69	No	Yes	2	0	5
18	L:L:F22	L:L:L26	12.9194	9.74	Yes	No	2	0	0
19	L:L:F22	R:R:W214	14.6333	9.02	Yes	Yes	0	0	1
20	R:R:W39	R:R:Y88	16.0785	8.68	Yes	Yes	2	5	5
21	L:L:F22	R:R:W39	12.9576	5.01	Yes	Yes	2	0	5
22	L:L:Q19	R:R:P90	11.4506	9.47	Yes	No	0	0	4
23	R:R:Y69	R:R:Y88	43.6957	7.94	No	Yes	0	6	5
24	L:L:I27	R:R:Y69	43.0107	3.63	No	No	0	0	6
25	R:R:Q234	R:R:W284	19.1782	12.05	Yes	Yes	1	7	8
26	R:R:I308	R:R:W284	11.3017	3.52	No	Yes	0	8	8
27	L:L:I27	R:R:L123	41.5827	2.85	No	No	0	0	5
28	R:R:L123	R:R:R121	40.8858	14.58	No	No	0	5	6
29	R:R:D67	R:R:R121	40.1626	4.76	No	No	0	9	6
30	R:R:D67	R:R:W72	39.442	4.47	No	Yes	0	9	9
31	R:R:W110	R:R:W72	31.3336	10.31	Yes	Yes	0	9	9
32	R:R:C62	R:R:W110	15.7425	6.53	No	Yes	5	9	9
33	R:R:C62	R:R:G75	14.9613	1.96	No	No	0	9	7
34	R:R:G75	R:R:S79	14.1525	1.86	No	No	0	7	5
35	R:R:E76	R:R:S79	12.5268	2.87	No	No	0	1	5
36	R:R:P119	R:R:W110	14.1525	12.16	No	Yes	0	6	9
37	R:R:L118	R:R:P119	12.5268	1.64	No	No	0	4	6
38	R:R:K113	R:R:L118	10.8907	16.92	No	No	0	4	4
39	R:R:K113	R:R:W120	10.0686	8.12	No	Yes	0	4	5
40	R:R:N240	R:R:R190	100	9.64	No	Yes	0	9	8
41	R:R:F187	R:R:N240	82.8215	12.08	Yes	No	0	8	9
42	R:R:F187	R:R:L159	24.9694	3.65	Yes	Yes	0	8	9
43	R:R:F184	R:R:L159	19.8145	6.09	No	Yes	0	8	9
44	R:R:F184	R:R:L166	18.6289	4.87	No	Yes	0	8	8
45	R:R:C403	R:R:L166	16.5593	3.17	No	Yes	0	9	8
46	R:R:C403	R:R:I165	15.1049	3.27	No	No	0	9	8
47	R:R:N240	R:R:S186	30.3627	7.45	No	No	0	9	9
48	R:R:S186	R:R:W243	29.6342	7.41	No	Yes	0	9	9
49	R:R:F187	R:R:L183	58.1288	7.31	Yes	No	0	8	9
50	R:R:E247	R:R:L183	58.0142	6.63	Yes	No	0	9	9
51	R:R:E247	R:R:H180	27.4197	11.08	Yes	No	0	9	9
52	R:R:H180	R:R:Y402	27.6858	4.36	No	Yes	0	9	8
53	R:R:E247	R:R:L359	26.7096	10.6	Yes	No	0	9	9
54	R:R:L359	R:R:Y402	26.0483	17.58	No	Yes	0	9	8
55	R:R:M233	R:R:Q234	10.3861	4.08	No	Yes	0	6	7
56	R:R:V246	R:R:W243	18.3904	6.13	No	Yes	0	8	9
57	R:R:I272	R:R:V246	11.3597	3.07	Yes	No	0	6	8
58	R:R:L401	R:R:Y402	36.6874	4.69	No	Yes	0	8	8
59	R:R:L401	R:R:P358	33.8129	4.93	No	No	0	8	9
60	R:R:I357	R:R:P358	30.9278	3.39	No	No	0	8	9
61	R:R:I357	R:R:T362	28.0322	4.56	No	No	0	8	7
62	R:R:F324	R:R:T362	26.5805	9.08	Yes	No	0	9	7
63	R:R:F324	R:R:L356	10.3637	7.31	Yes	No	10	9	9
64	R:R:F324	R:R:L360	11.8444	3.65	Yes	No	10	9	9
65	R:R:L360	R:R:N320	10.4375	8.24	No	No	0	9	9
66	R:R:T355	R:R:Y402	16.2892	2.5	No	Yes	0	8	8
67	R:R:K351	R:R:T355	14.8349	3	No	No	0	8	8
68	R:R:K351	R:R:R348	13.3594	12.38	No	No	0	8	8
69	R:R:R348	R:R:S352	10.4375	5.27	No	No	0	8	9
70	L:L:E3	L:L:Y1	15.5673	3.37	Yes	Yes	1	0	0
71	L:L:E3	R:R:L388	37.8414	3.98	Yes	Yes	1	0	7
72	R:R:R190	R:R:V237	12.6928	10.46	Yes	No	0	8	6
73	R:R:Y148	R:R:Y152	48.2973	4.96	Yes	Yes	1	7	7
74	L:L:F6	R:R:Y148	38.1839	8.25	Yes	Yes	1	0	7
75	R:R:L89	R:R:P90	10.1477	3.28	Yes	No	2	5	4
76	R:R:R190	R:R:Y152	48.2538	7.2	Yes	Yes	1	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Y1	R:R:Q234	11.27	1	Yes	Yes	0	7	0	1
L:L:Y1	R:R:V237	8.83	1	Yes	No	0	6	0	1
L:L:Y1	R:R:W306	5.79	1	Yes	Yes	0	6	0	1
L:L:?2	R:R:E387	6.34	1	Yes	No	0	8	0	1
L:L:?2	R:R:L388	3.98	1	Yes	Yes	0	7	0	1
L:L:E3	R:R:Y152	8.98	1	Yes	Yes	0	7	0	1
L:L:E3	R:R:R190	8.14	1	Yes	Yes	0	8	0	1
L:L:E3	R:R:L388	3.98	1	Yes	Yes	0	7	0	1
L:L:T5	R:R:W306	4.85	1	No	Yes	0	6	0	1
L:L:T5	R:R:D372	14.45	1	No	Yes	0	5	0	1
L:L:F6	R:R:L141	6.09	1	Yes	No	0	5	0	1
L:L:F6	R:R:L144	4.87	1	Yes	Yes	0	6	0	1
L:L:F6	R:R:Y148	8.25	1	Yes	Yes	0	7	0	1
L:L:F6	R:R:L388	3.65	1	Yes	Yes	0	7	0	1
L:L:T7	R:R:K197	10.51	0	No	Yes	0	6	0	1
L:L:S8	R:R:N300	7.45	0	No	No	0	6	0	1
L:L:D9	R:R:R380	11.91	0	No	No	0	5	0	1
L:L:Y10	R:R:L141	4.69	1	No	No	0	5	0	1
L:L:S11	R:R:Y205	3.82	3	No	Yes	0	3	0	1
L:L:S11	R:R:T298	6.4	3	No	Yes	0	5	0	1
L:L:S11	R:R:R299	5.27	3	No	Yes	0	4	0	1
L:L:I12	R:R:R299	3.76	0	No	Yes	0	4	0	1
L:L:L14	R:R:Y205	8.21	0	No	Yes	0	3	0	1
L:L:D15	R:R:Y205	9.2	0	No	Yes	0	3	0	1
L:L:D15	R:R:R299	4.76	0	No	Yes	0	4	0	1
L:L:K16	R:R:W91	3.48	0	No	Yes	0	4	0	1
L:L:A18	R:R:Q210	6.06	0	No	No	0	4	0	1
L:L:Q19	R:R:V30	4.3	0	Yes	No	0	2	0	1
L:L:Q19	R:R:T35	5.67	0	Yes	No	0	5	0	1
L:L:Q19	R:R:P90	9.47	0	Yes	No	0	4	0	1
L:L:F22	R:R:W39	5.01	2	Yes	Yes	0	5	0	1
L:L:F22	R:R:W214	9.02	2	Yes	Yes	0	1	0	1
L:L:W25	R:R:E68	5.45	0	No	No	0	4	0	1
L:L:W25	R:R:W214	27.18	0	No	Yes	0	1	0	1
L:L:L26	R:R:W39	7.97	2	No	Yes	0	5	0	1
L:L:L26	R:R:Y88	4.69	2	No	Yes	0	5	0	1
L:L:I27	R:R:Y69	3.63	0	No	No	0	6	0	1
L:L:G29	R:R:E68	4.91	0	No	No	0	4	0	1
R:R:R43	R:R:W39	7	0	No	Yes	4	5	2	1
R:R:W39	R:R:Y88	8.68	2	Yes	Yes	5	5	1	1
R:R:P86	R:R:Y42	8.34	2	No	Yes	8	6	2	2
R:R:Y42	R:R:Y88	3.97	2	Yes	Yes	6	5	2	1
R:R:Y69	R:R:Y88	7.94	0	No	Yes	6	5	1	1
R:R:P86	R:R:Y88	8.34	2	No	Yes	8	5	2	1
R:R:L89	R:R:Y88	8.21	2	Yes	Yes	5	5	2	1
R:R:L89	R:R:P90	3.28	2	Yes	No	5	4	2	1
R:R:L89	R:R:W91	5.69	2	Yes	Yes	5	4	2	1
R:R:P90	R:R:W91	14.86	2	No	Yes	4	4	1	1
R:R:S94	R:R:W91	3.71	0	No	Yes	4	4	2	1
R:R:E128	R:R:W91	9.81	0	No	Yes	3	4	2	1
R:R:L123	R:R:R121	14.58	0	No	No	5	6	1	2
R:R:F381	R:R:L144	4.87	1	No	Yes	4	6	2	1
R:R:L144	R:R:L384	4.15	1	Yes	No	6	5	1	2
R:R:F385	R:R:L144	3.65	1	Yes	Yes	6	6	2	1
R:R:Y148	R:R:Y152	4.96	1	Yes	Yes	7	7	1	1
R:R:K197	R:R:Y148	4.78	1	Yes	Yes	6	7	1	1
R:R:D198	R:R:Y148	9.2	1	No	Yes	7	7	2	1
R:R:L388	R:R:Y148	3.52	1	Yes	Yes	7	7	1	1
R:R:R190	R:R:Y152	7.2	1	Yes	Yes	8	7	1	1
R:R:A191	R:R:Y152	5.34	0	No	Yes	7	7	2	1
R:R:V194	R:R:Y152	11.36	0	No	Yes	7	7	2	1
R:R:S392	R:R:Y152	16.53	0	No	Yes	9	7	2	1
R:R:R190	R:R:V237	10.46	1	Yes	No	8	6	1	1
R:R:N240	R:R:R190	9.64	0	No	Yes	9	8	2	1
R:R:R190	R:R:Y241	9.26	1	Yes	Yes	8	8	1	2
R:R:R190	R:R:T391	5.17	1	Yes	No	8	6	1	2
R:R:D198	R:R:K197	12.44	1	No	Yes	7	6	2	1
R:R:F230	R:R:K197	4.96	0	Yes	Yes	5	6	2	1
R:R:K197	R:R:M233	8.64	1	Yes	No	6	6	1	2
R:R:M204	R:R:Y205	7.18	3	Yes	Yes	3	3	2	1
R:R:M204	R:R:T298	4.52	3	Yes	Yes	3	5	2	1
R:R:Q210	R:R:W214	6.57	0	No	Yes	4	1	1	1
R:R:Q211	R:R:W214	6.57	0	No	Yes	4	1	2	1
R:R:F230	R:R:T298	7.78	0	Yes	Yes	5	5	2	1
R:R:M233	R:R:Q234	4.08	0	No	Yes	6	7	2	1
R:R:Q234	R:R:W284	12.05	1	Yes	Yes	7	8	1	2
R:R:I309	R:R:Q234	5.49	1	No	Yes	7	7	2	1
R:R:I309	R:R:W284	11.74	1	No	Yes	7	8	2	2
R:R:R299	R:R:T298	3.88	3	Yes	Yes	4	5	1	1
R:R:M303	R:R:N300	4.21	0	No	No	5	6	2	1
R:R:N300	R:R:W306	14.69	0	No	Yes	6	6	1	1
R:R:D372	R:R:M303	5.54	1	Yes	No	5	5	1	2
R:R:I309	R:R:W306	5.87	1	No	Yes	7	6	2	1
R:R:R310	R:R:W306	19.99	0	Yes	Yes	6	6	2	1
R:R:D372	R:R:W306	5.58	1	Yes	Yes	5	6	1	1
R:R:F367	R:R:T386	10.38	1	Yes	No	7	4	2	2
R:R:E387	R:R:F367	5.83	1	No	Yes	8	7	1	2
R:R:D372	R:R:R380	9.53	1	Yes	No	5	5	1	1
R:R:F381	R:R:F385	4.29	1	No	Yes	4	6	2	2
R:R:E387	R:R:T386	5.64	1	No	No	8	4	1	2
L:L:I27	R:R:L123	2.85	0	No	No	0	5	0	1
R:R:A375	R:R:R380	2.77	0	No	No	4	5	2	1
R:R:E138	R:R:L141	2.65	0	No	No	2	5	2	1
L:L:F22	R:R:V36	2.62	2	Yes	No	0	2	0	1
R:R:R40	R:R:V36	2.62	0	Yes	No	2	2	2	1
L:L:V23	R:R:Y88	2.52	0	No	Yes	0	5	0	1
R:R:F195	R:R:Y152	2.06	0	No	Yes	7	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7VBI_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.17
Number of Linked Nodes	382
Number of Links	420
Number of Hubs	57
Number of Links mediated by Hubs	212
Number of Communities	10
Number of Nodes involved in Communities	69
Number of Links involved in Communities	90

Path Summary
Number Of Nodes in MetaPath	77
Number Of Links MetaPath	76
Number of Shortest Paths	134260
Length Of Smallest Path	3
Average Path Length	18.2019
Length of Longest Path	45
Minimum Path Strength	1.5
Average Path Strength	6.79747
Maximum Path Strength	18.1
Minimum Path Correlation	0.7
Average Path Correlation	0.958388
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	56.7207
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.8238
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • plasma membrane • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body • glucagon receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • amide binding • peptide hormone binding • hormone binding • glucagon-like peptide 1 receptor activity • heart process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • regulation of blood pressure • positive regulation of blood pressure • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to psychosocial stress • cell surface receptor signaling pathway • behavior • learning or memory • cognition • transport • secretion • regulation of hormone levels • cell-cell signaling • export from cell • hormone secretion • establishment of localization • localization • secretion by cell • signal release • hormone transport • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • establishment of protein localization • cellular localization • nitrogen compound transport • protein targeting • protein transmembrane transport • establishment of localization in cell • post-translational protein targeting to membrane, translocation • intracellular protein localization • establishment of protein localization to endoplasmic reticulum • establishment of protein localization to membrane • intracellular protein transmembrane transport • intracellular transport • post-translational protein targeting to endoplasmic reticulum membrane • localization within membrane • protein targeting to membrane • transmembrane transport • establishment of protein localization to organelle • protein transport • macromolecule localization • intracellular protein transport • protein targeting to ER • negative regulation of blood pressure • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • cellular response to nitrogen compound • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • response to hormone • cellular response to hormone stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • amide transport • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • regulation of protein transport • protein secretion • regulation of protein secretion • regulation of secretion • peptide transport • regulation of insulin secretion • peptide hormone secretion • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • FnI-like domain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • FnI-like domain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	AIB
PDB Residues	L:L:?2 L:L:?13
Environment Details	Open EMBL-EBI Page
Code	AIB
Name	2-aminoisobutyric acid
Synonyms	α-aminoisobutyric acid
Identifier
Formula	C4 H9 N O2
Molecular Weight	103.12
SMILES
PubChem	5245672
Formal Charge	0
Total Atoms	16
Total Chiral Atoms	0
Total Bonds	15
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43220
Sequence	>7VBI_nogp_Chain_R A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F R H L H C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S T A A Q Q H Q W D G L L S Y Q D S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S V L S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E D E G C W T R N S N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A D I K C R L A K S T L T L I P L L G T H E V I F A F V M D E H A R G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E V Q L E F R K S W E R W R L E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	7E14	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738	Gs/β1/γ2	2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7E14 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738		2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7DUQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738	Gs/β1/γ2	2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DUQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738		2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DUR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7DUR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	5VEW	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.7	2017-05-24	doi.org/10.1038/nature22378
	6LN2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.2	2020-03-18	doi.org/10.1038/s41467-020-14934-5
	6KJV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.1	2019-11-13	doi.org/10.1107/S2052252519013496
	5VEX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	NNC0640	-	3	2017-05-17	doi.org/10.1038/nature22378
	9IVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839	chim(NtGi1-Gs)/β2/γ2	3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	9IVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839		3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	6VCB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440	Gs/β1/γ2	3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	6VCB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440		3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	9IVG	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	chim(NtGi1-Gs)/β1/γ2	3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	9IVG (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-		3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	7RTB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-	Gs/β1/γ2	2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7RTB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-		2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7KI0	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI0 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	6X18	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X18 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	7LCI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCJ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	2.82	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCK	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	3.24	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7S15	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 134611223	-	-	3.8	2022-06-08	doi.org/10.1021/acs.jmedchem.1c01856
	9J1P	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-	chim(NtGi1-Gs)/β1/γ2	2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	9J1P (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-		2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	5VAI	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-	Gs/β1/γ2	4.1	2017-05-24	doi.org/10.1038/nature22394
	5VAI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-		4.1	2017-05-24	doi.org/10.1038/nature22394
	5NX2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	-	3.7	2017-06-14	doi.org/10.1038/nature22800
	6B3J	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-	Gs/β1/γ2	3.3	2018-02-21	doi.org/10.1038/nature25773
	6B3J (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-		3.3	2018-02-21	doi.org/10.1038/nature25773
	8WG7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WG7 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	7C2E	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-	Gs/β1/γ2	4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	7C2E (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-		4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	7LLL	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLL (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-	Gs/β1/γ2	3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-		3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7FIM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-	Gs/β1/γ2	3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-		3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBH	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7VBH (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-		3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7S1M	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-	Gs/β1/γ2	2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S1M (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-		2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	6XOX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-	chim(NtGi1-Gs)/β1/γ2	3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	6XOX (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-		3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	7RG9	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RG9 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7X8R	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-	Gs/β1/γ2	2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8R (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-		2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-	Gs/β1/γ2	3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-		3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	8JIP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-	chim(NtGi1-Gs)/β1/γ2	2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-		2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-	chim(NtGi1-Gs)/β1/γ2	2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-		2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIS	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-	chim(NtGi1-Gs)/β1/γ2	2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8JIS (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-		2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8YW3	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	9EBN	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBN (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-	Gs/β1/γ2	3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-		3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	8YWF	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ2	2.74	2025-04-16	To be published
	8YWF (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.74	2025-04-16	To be published
	9BYO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-	Gs/β1/γ2	2.31	2025-06-11	To be published
	9BYO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-		2.31	2025-06-11	To be published
	9C0K	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	2.72	2025-06-11	To be published
	9C0K (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		2.72	2025-06-11	To be published

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Download 7VBI_nogp.zip

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