psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E138	R:R:P137	14.15	No	No	0	2	3
2	R:R:I382	R:R:Q140	4.12	No	No	0	4	4
3	R:R:L142	R:R:Y145	3.52	No	Yes	0	3	5
4	R:R:F385	R:R:L144	4.87	No	No	0	6	6
5	R:R:T149	R:R:Y145	8.74	No	Yes	0	7	5
6	R:R:D198	R:R:Y145	10.34	No	Yes	0	7	5
7	R:R:Y148	R:R:Y152	16.88	No	Yes	2	7	7
8	R:R:V194	R:R:Y148	6.31	No	No	2	7	7
9	R:R:L388	R:R:Y148	4.69	No	No	0	7	7
10	R:R:G151	R:R:S392	3.71	No	No	2	8	9
11	R:R:F393	R:R:G151	9.03	No	No	2	7	8
12	R:R:R190	R:R:Y152	8.23	Yes	Yes	0	8	7
13	R:R:V194	R:R:Y152	15.14	No	Yes	2	7	7
14	R:R:S392	R:R:Y152	3.82	No	Yes	2	9	7
15	R:R:G395	R:R:S155	3.71	No	No	0	9	9
16	R:R:L396	R:R:S155	3	No	No	0	7	9
17	R:R:F156	R:R:V160	5.24	Yes	No	0	7	3
18	R:R:F156	R:R:F195	4.29	Yes	No	6	7	7
19	R:R:F184	R:R:L159	4.87	No	No	0	8	9
20	R:R:I188	R:R:L159	4.28	No	No	0	7	9
21	R:R:A399	R:R:L159	3.15	No	No	0	8	9
22	R:R:A162	R:R:C403	3.61	No	No	7	9	9
23	R:R:A162	R:R:F404	4.16	No	Yes	7	9	8
24	R:R:C403	R:R:I165	4.91	No	No	0	9	8
25	R:R:F413	R:R:I165	7.54	No	No	0	5	8
26	R:R:L166	R:R:N177	9.61	No	Yes	0	8	9
27	R:R:L166	R:R:L181	5.54	No	No	0	8	6
28	R:R:F184	R:R:L166	4.87	No	No	0	8	8
29	R:R:L167	R:R:L181	4.15	No	No	0	3	6
30	R:R:F169	R:R:L172	4.87	Yes	No	4	7	9
31	R:R:E412	R:R:F169	15.16	Yes	Yes	4	8	7
32	R:R:F169	R:R:F413	7.5	Yes	No	0	7	5
33	R:R:H173	R:R:R170	3.39	No	No	0	7	8
34	R:R:E412	R:R:H171	12.31	Yes	No	4	8	7
35	R:R:H171	R:R:K415	9.17	No	No	4	7	7
36	R:R:L172	R:R:V409	4.47	No	No	0	9	9
37	R:R:E412	R:R:L172	3.98	Yes	No	4	8	9
38	R:R:H173	R:R:Y178	6.53	No	No	0	7	6
39	R:R:C174	R:R:R176	4.18	No	Yes	3	8	9
40	R:R:C174	R:R:N177	4.72	No	Yes	3	8	9
41	R:R:T175	R:R:Y250	3.75	No	Yes	0	7	8
42	R:R:N177	R:R:R176	6.03	Yes	Yes	3	9	9
43	R:R:H180	R:R:R176	4.51	Yes	Yes	3	9	9
44	R:R:R176	R:R:Y250	4.12	Yes	Yes	0	9	8
45	R:R:I345	R:R:R176	3.76	No	Yes	0	5	9
46	R:R:L349	R:R:R176	6.07	No	Yes	0	9	9
47	R:R:H180	R:R:N177	3.83	Yes	Yes	3	9	9
48	R:R:E247	R:R:I179	5.47	No	No	0	9	8
49	R:R:I179	R:R:Y250	6.04	No	Yes	0	8	8
50	R:R:E247	R:R:H180	9.85	No	Yes	3	9	9
51	R:R:H180	R:R:Y402	17.42	Yes	Yes	3	9	8
52	R:R:N182	R:R:W243	18.08	No	Yes	8	9	9
53	R:R:N182	R:R:W274	5.65	No	Yes	8	9	9
54	R:R:F187	R:R:L183	4.87	Yes	No	0	8	9
55	R:R:N240	R:R:S186	7.45	No	No	0	9	9
56	R:R:F187	R:R:N240	20.54	Yes	No	0	8	9
57	R:R:F187	R:R:Q394	3.51	Yes	Yes	0	8	9
58	R:R:F187	R:R:G395	6.02	Yes	No	5	8	9
59	R:R:F187	R:R:V398	3.93	Yes	No	5	8	9
60	R:R:C236	R:R:L189	4.76	No	No	0	5	7
61	R:R:R190	R:R:V237	6.54	Yes	No	0	8	6
62	R:R:N240	R:R:R190	6.03	No	Yes	0	9	8
63	R:R:Q394	R:R:R190	4.67	Yes	Yes	0	9	8
64	R:R:C193	R:R:L232	4.76	No	No	0	6	5
65	R:R:C193	R:R:M233	6.48	No	No	0	6	6
66	R:R:M233	R:R:V194	3.04	No	No	0	6	7
67	R:R:K197	R:R:Y220	4.78	No	Yes	0	6	3
68	R:R:A200	R:R:Y220	5.34	No	Yes	0	4	3
69	R:R:D222	R:R:L218	16.29	No	No	0	6	3
70	R:R:S223	R:R:Y220	3.82	No	Yes	0	4	3
71	R:R:C226	R:R:Y220	14.79	No	Yes	0	9	3
72	R:R:V229	R:R:Y220	3.79	No	Yes	0	7	3
73	R:R:G295	R:R:Q221	6.58	No	No	0	4	4
74	R:R:C296	R:R:Q221	3.05	No	No	0	9	4
75	R:R:L224	R:R:L228	4.15	No	No	0	3	4
76	R:R:C226	R:R:C296	7.28	No	No	0	9	9
77	R:R:D293	R:R:R227	15.48	No	No	1	7	8
78	R:R:G295	R:R:R227	3	No	No	0	4	8
79	R:R:R227	R:R:W297	16.99	No	Yes	1	8	8
80	R:R:F230	R:R:Q234	7.03	No	No	1	5	7
81	R:R:F230	R:R:W284	6.01	No	Yes	1	5	8
82	R:R:F230	R:R:W297	3.01	No	Yes	1	5	8
83	R:R:Q234	R:R:W284	4.38	No	Yes	1	7	8
84	R:R:I309	R:R:Q234	4.12	No	No	1	7	7
85	R:R:W274	R:R:Y235	7.72	Yes	No	0	9	9
86	R:R:L278	R:R:Y235	4.69	No	No	0	3	9
87	R:R:A238	R:R:P277	3.74	No	Yes	0	6	9
88	R:R:I313	R:R:Y241	7.25	No	No	0	7	8
89	R:R:V276	R:R:Y242	6.31	No	Yes	9	3	6
90	R:R:P277	R:R:Y242	6.95	Yes	Yes	9	9	6
91	R:R:F280	R:R:Y242	4.13	No	Yes	0	5	6
92	R:R:A316	R:R:Y242	8.01	No	Yes	0	7	6
93	R:R:V246	R:R:W243	3.68	No	Yes	0	8	9
94	R:R:V270	R:R:W243	4.9	No	Yes	0	5	9
95	R:R:G273	R:R:W243	8.44	No	Yes	0	9	9
96	R:R:W243	R:R:W274	18.74	Yes	Yes	8	9	9
97	R:R:L244	R:R:N320	4.12	No	No	0	9	9
98	R:R:L245	R:R:V319	5.96	No	No	0	8	6
99	R:R:L245	R:R:N320	6.87	No	No	0	8	9
100	R:R:V246	R:R:Y269	7.57	No	Yes	0	8	7
101	R:R:I272	R:R:V246	6.14	No	No	0	6	8
102	R:R:E247	R:R:Y402	13.47	No	Yes	3	9	8
103	R:R:L254	R:R:Y250	3.52	No	Yes	0	8	8
104	R:R:Y250	R:R:Y269	3.97	Yes	Yes	0	8	7
105	R:R:L251	R:R:L349	4.15	No	No	0	9	9
106	R:R:A350	R:R:L251	3.15	No	No	0	8	9
107	R:R:L251	R:R:T353	4.42	No	Yes	0	9	9
108	R:R:R326	R:R:Y252	7.2	No	No	0	8	8
109	R:R:L255	R:R:V327	4.47	No	No	0	8	9
110	R:R:I330	R:R:L255	4.28	No	No	0	9	8
111	R:R:E262	R:R:W264	13.08	No	No	0	6	5
112	R:R:I265	R:R:W264	14.09	No	No	0	5	5
113	R:R:I265	R:R:Y269	6.04	No	Yes	0	5	7
114	R:R:P277	R:R:V276	3.53	Yes	No	9	9	3
115	R:R:F280	R:R:P312	18.78	No	No	0	5	8
116	R:R:P283	R:R:V282	5.3	No	No	0	5	3
117	R:R:G285	R:R:W284	5.63	No	Yes	0	5	8
118	R:R:K288	R:R:W284	10.44	Yes	Yes	1	8	8
119	R:R:W284	R:R:W297	4.69	Yes	Yes	1	8	8
120	R:R:I308	R:R:W284	5.87	No	Yes	0	8	8
121	R:R:I309	R:R:W284	10.57	No	Yes	1	7	8
122	R:R:V287	R:R:Y305	11.36	No	Yes	0	4	4
123	R:R:E292	R:R:K288	14.85	No	Yes	0	6	8
124	R:R:K288	R:R:W297	9.28	Yes	Yes	1	8	8
125	R:R:K288	R:R:N300	8.39	Yes	No	0	8	6
126	R:R:L290	R:R:Y291	7.03	No	No	0	3	3
127	R:R:Y291	R:R:Y305	5.96	No	Yes	0	3	4
128	R:R:E292	R:R:N302	13.15	No	No	0	6	5
129	R:R:E292	R:R:Y305	11.22	No	Yes	0	6	4
130	R:R:D293	R:R:W297	6.7	No	Yes	1	7	8
131	R:R:N300	R:R:W306	10.17	No	No	0	6	6
132	R:R:M303	R:R:N302	4.21	No	No	0	5	5
133	R:R:M303	R:R:Y305	7.18	No	Yes	0	5	4
134	R:R:L307	R:R:N304	5.49	Yes	No	0	7	3
135	R:R:R310	R:R:W306	13.99	No	No	0	6	6
136	R:R:L307	R:R:L311	6.92	Yes	No	10	7	4
137	R:R:E364	R:R:R310	8.14	No	No	0	8	6
138	R:R:E364	R:R:I313	4.1	No	No	0	8	7
139	R:R:I318	R:R:L314	4.28	No	No	0	4	4
140	R:R:A368	R:R:L314	3.15	No	No	0	6	4
141	R:R:F315	R:R:V319	3.93	No	No	0	4	6
142	R:R:C317	R:R:C361	7.28	No	No	0	7	9
143	R:R:C317	R:R:E364	3.04	No	No	0	7	8
144	R:R:C361	R:R:N320	3.15	No	No	0	9	9
145	R:R:F321	R:R:F324	3.22	Yes	Yes	0	6	9
146	R:R:C361	R:R:F321	4.19	No	Yes	0	9	6
147	R:R:F324	R:R:I328	5.02	Yes	No	0	9	7
148	R:R:F324	R:R:L354	6.09	Yes	No	0	9	8
149	R:R:F324	R:R:I357	6.28	Yes	No	11	9	8
150	R:R:F324	R:R:P358	7.22	Yes	No	11	9	9
151	R:R:C329	R:R:R326	5.57	No	No	0	7	8
152	R:R:I330	R:R:R326	3.76	No	No	0	9	8
153	R:R:L354	R:R:V327	5.96	No	No	0	8	9
154	R:R:V331	W:W:?1	5.02	No	Yes	0	8	0
155	R:R:V332	W:W:?1	3.01	No	Yes	0	6	0
156	R:R:K334	R:R:L339	5.64	No	No	0	9	7
157	R:R:K334	R:R:M340	5.76	No	No	0	9	5
158	R:R:A337	R:R:L339	3.15	No	No	0	7	7
159	R:R:D344	R:R:M340	4.16	No	No	0	7	5
160	R:R:A346	R:R:M340	3.22	No	No	0	6	5
161	R:R:F347	R:R:K342	21.09	No	No	0	7	5
162	R:R:I345	R:R:R348	5.01	No	Yes	0	5	8
163	R:R:F347	R:R:K351	6.2	No	No	12	7	8
164	R:R:F347	W:W:?1	5.75	No	Yes	12	7	0
165	R:R:N407	R:R:R348	10.85	No	Yes	0	6	8
166	R:R:E408	R:R:R348	11.63	No	Yes	0	9	8
167	R:R:R348	W:W:?1	6.56	Yes	Yes	0	8	0
168	R:R:A350	R:R:L354	3.15	No	No	0	8	8
169	R:R:K351	W:W:?1	31.39	No	Yes	12	8	0
170	R:R:L401	R:R:S352	3	No	No	0	8	9
171	R:R:S352	R:R:Y402	6.36	No	Yes	0	9	8
172	R:R:S352	W:W:?1	9.11	No	Yes	0	9	0
173	R:R:I357	R:R:T353	3.04	No	Yes	0	8	9
174	R:R:T353	R:R:Y402	6.24	Yes	Yes	0	9	8
175	R:R:T355	W:W:?1	11.93	No	Yes	0	8	0
176	R:R:L356	R:R:Y402	5.86	No	Yes	0	9	8
177	R:R:I357	R:R:P358	3.39	No	No	11	8	9
178	R:R:L359	R:R:L360	4.15	No	No	0	9	9
179	R:R:L360	R:R:Q394	9.32	No	Yes	0	9	9
180	R:R:I366	R:R:T362	4.56	No	No	0	6	7
181	R:R:F367	R:R:H363	6.79	No	No	0	7	8
182	R:R:E387	R:R:H363	12.31	No	No	0	8	8
183	R:R:F367	R:R:I366	10.05	No	No	0	7	6
184	R:R:A368	R:R:F369	4.16	No	No	0	6	4
185	R:R:K383	R:R:R380	14.85	No	No	0	7	5
186	R:R:F385	R:R:L388	7.31	No	No	0	6	7
187	R:R:F393	R:R:S392	5.28	No	No	2	7	9
188	R:R:G395	R:R:V398	3.68	No	No	5	9	9
189	R:R:I400	R:R:L396	4.28	No	No	0	6	7
190	R:R:A399	R:R:F404	4.16	No	Yes	0	8	8
191	R:R:F404	R:R:I400	5.02	Yes	No	0	8	6
192	R:R:C403	R:R:F404	5.59	No	Yes	7	9	8
193	R:R:V405	W:W:?1	4.02	No	Yes	0	6	0
194	R:R:E408	R:R:N406	13.15	No	No	0	9	9
195	R:R:N406	R:R:V409	7.39	No	No	0	9	9
196	R:R:N406	W:W:?1	4.63	No	Yes	0	9	0
197	R:R:E412	R:R:K415	8.1	Yes	No	4	8	7
198	R:R:R414	R:R:W417	6	No	No	0	6	5
199	R:R:K415	R:R:R419	6.19	No	No	0	7	7
200	R:R:W417	R:R:W420	14.06	No	No	0	5	4
201	R:R:L231	R:R:V281	2.98	No	No	0	5	6
202	R:R:L245	R:R:V249	2.98	No	No	0	8	6
203	R:R:L278	R:R:V282	2.98	No	No	0	3	3
204	R:R:L335	R:R:V331	2.98	No	No	0	8	8
205	R:R:I161	R:R:I165	2.94	No	No	0	4	8
206	R:R:I330	R:R:K334	2.91	No	No	0	9	9
207	R:R:D344	R:R:T343	2.89	No	No	0	7	5
208	R:R:E139	R:R:S136	2.87	No	No	0	2	1
209	R:R:I147	R:R:L144	2.85	No	No	0	6	6
210	R:R:Q394	R:R:T391	2.83	Yes	No	0	9	6
211	R:R:L401	R:R:M397	2.83	No	No	0	8	5
212	R:R:P277	R:R:Y235	2.78	Yes	No	0	9	9
213	R:R:A191	R:R:F156	2.77	No	Yes	6	7	7
214	R:R:A158	R:R:F404	2.77	No	Yes	0	7	8
215	R:R:A191	R:R:F195	2.77	No	No	6	7	7
216	R:R:D198	R:R:L201	2.71	No	No	0	7	7
217	R:R:F196	R:R:V229	2.62	No	No	0	5	7
218	R:R:F266	R:R:V270	2.62	No	No	0	6	5
219	R:R:R267	R:R:V270	2.62	No	No	0	4	5
220	R:R:F280	R:R:V281	2.62	No	No	0	5	6
221	R:R:F321	R:R:V365	2.62	Yes	No	0	6	6
222	R:R:A185	R:R:W274	2.59	No	Yes	0	3	9
223	R:R:A239	R:R:W274	2.59	No	Yes	0	8	9
224	R:R:F321	R:R:T362	2.59	Yes	No	0	6	7
225	R:R:F156	R:R:I188	2.51	Yes	No	0	7	7
226	R:R:F369	R:R:L307	2.44	No	Yes	10	4	7
227	R:R:F369	R:R:L311	2.44	No	No	10	4	4
228	R:R:I146	R:R:Y145	2.42	No	Yes	0	4	5
229	R:R:L224	R:R:Y289	2.34	No	No	0	3	3
230	R:R:E294	R:R:R299	2.33	No	No	0	4	4
231	R:R:E418	R:R:R414	2.33	No	No	0	4	6
232	R:R:L307	R:R:W306	2.28	Yes	No	0	7	6
233	R:R:F266	R:R:Y178	2.06	No	No	0	6	6
234	R:R:G275	R:R:P277	2.03	No	Yes	0	6	9
235	R:R:W297	R:R:Y289	1.93	Yes	No	0	8	3
236	R:R:G151	R:R:V150	1.84	No	No	0	8	5
237	R:R:G248	R:R:T353	1.82	No	Yes	0	8	9
238	R:R:P137	R:R:S136	1.78	No	No	0	3	1
239	R:R:G248	R:R:I323	1.76	No	No	0	8	8
240	R:R:G168	R:R:L167	1.71	No	No	0	1	3
241	R:R:A225	R:R:S223	1.71	No	No	0	3	4
242	R:R:C341	R:R:T343	1.69	No	No	0	4	5
243	R:R:S389	R:R:T386	1.6	No	No	0	5	4
244	R:R:T149	R:R:V150	1.59	No	No	0	7	5
245	R:R:I147	R:R:S389	1.55	No	No	0	6	5
246	R:R:I188	R:R:S163	1.55	No	No	0	7	6
247	R:R:D222	R:R:S223	1.47	No	No	0	6	4
248	R:R:I382	R:R:K383	1.45	No	No	0	4	7
249	R:R:I286	R:R:L290	1.43	No	No	0	4	3
250	R:R:I318	R:R:L322	1.43	No	No	0	4	5
251	R:R:Q410	R:R:V409	1.43	No	No	0	7	9
252	R:R:Q221	R:R:T298	1.42	No	No	0	4	5
253	R:R:C236	R:R:R190	1.39	No	Yes	0	5	8
254	R:R:E387	R:R:L384	1.33	No	No	0	8	5
255	R:R:F169	R:R:S416	1.32	Yes	No	0	7	5
256	R:R:F390	R:R:S389	1.32	No	No	0	6	5
257	R:R:F324	R:R:V325	1.31	Yes	No	0	9	5
258	R:R:F367	R:R:V370	1.31	No	No	0	7	5
259	R:R:T253	R:R:Y269	1.25	No	Yes	0	7	7
260	R:R:F385	R:R:L141	1.22	No	No	0	6	5
261	R:R:F393	R:R:L154	1.22	No	No	0	7	5
262	R:R:F156	R:R:L192	1.22	Yes	No	0	7	3
263	R:R:E418	R:R:R421	1.16	No	No	0	4	4
264	R:R:L217	R:R:W203	1.14	No	No	0	4	3
265	R:R:L268	R:R:W264	1.14	No	No	0	2	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y145	6.255	4	0	5
2	R:R:Y152	11.0175	4	2	7
3	R:R:F156	3.206	5	6	7
4	R:R:F169	7.2125	4	4	7
5	R:R:R176	4.77833	6	3	9
6	R:R:N177	6.0475	4	3	9
7	R:R:H180	8.9025	4	3	9
8	R:R:F187	7.774	5	5	8
9	R:R:R190	5.372	5	0	8
10	R:R:Y220	6.504	5	0	3
11	R:R:Y242	6.35	4	9	6
12	R:R:W243	10.768	5	8	9
13	R:R:Y250	4.28	5	0	8
14	R:R:Y269	4.7075	4	0	7
15	R:R:W274	7.458	5	8	9
16	R:R:P277	3.806	5	9	9
17	R:R:W284	6.79857	7	1	8
18	R:R:K288	10.74	4	1	8
19	R:R:W297	7.1	6	1	8
20	R:R:Y305	8.93	4	0	4
21	R:R:L307	4.2825	4	10	7
22	R:R:F321	3.155	4	0	6
23	R:R:F324	4.85667	6	11	9
24	R:R:R348	8.5125	4	0	8
25	R:R:T353	3.88	4	0	9
26	R:R:Q394	5.0825	4	0	9
27	R:R:Y402	9.87	5	3	8
28	R:R:F404	4.34	5	7	8
29	R:R:E412	9.8875	4	4	8
30	W:W:?1	9.04667	9	12	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F385	R:R:L388	13.7459	7.31	No	No	0	6	7
2	R:R:L388	R:R:Y148	15.6973	4.69	No	No	0	7	7
3	R:R:Y148	R:R:Y152	17.4718	16.88	No	Yes	2	7	7
4	R:R:S392	R:R:Y152	21.4894	3.82	No	Yes	2	9	7
5	R:R:G151	R:R:S392	15.616	3.71	No	No	2	8	9
6	R:R:G151	R:R:V150	13.7412	1.84	No	No	0	8	5
7	R:R:T149	R:R:V150	11.7802	1.59	No	No	0	7	5
8	R:R:R190	R:R:Y152	47.2307	8.23	Yes	Yes	0	8	7
9	R:R:F187	R:R:G395	59.9005	6.02	Yes	No	5	8	9
10	R:R:F187	R:R:N240	28.6302	20.54	Yes	No	0	8	9
11	R:R:N240	R:R:R190	27.0518	6.03	No	Yes	0	9	8
12	R:R:F187	R:R:Q394	30.4333	3.51	Yes	Yes	0	8	9
13	R:R:Q394	R:R:R190	27.3101	4.67	Yes	Yes	0	9	8
14	R:R:G395	R:R:S155	61.4023	3.71	No	No	0	9	9
15	R:R:L396	R:R:S155	61.9811	3	No	No	0	7	9
16	R:R:A399	R:R:L159	58.8244	3.15	No	No	0	8	9
17	R:R:A399	R:R:F404	58.3939	4.16	No	Yes	0	8	8
18	R:R:F404	R:R:I400	63.1098	5.02	Yes	No	0	8	6
19	R:R:I400	R:R:L396	62.5502	4.28	No	No	0	6	7
20	R:R:F184	R:R:L159	62.0767	4.87	No	No	0	8	9
21	R:R:C403	R:R:F404	10.3884	5.59	No	Yes	7	9	8
22	R:R:F184	R:R:L166	62.4498	4.87	No	No	0	8	8
23	R:R:L166	R:R:N177	64.2673	9.61	No	Yes	0	8	9
24	R:R:F169	R:R:F413	10.0201	7.5	Yes	No	0	7	5
25	R:R:V270	R:R:W243	14.0377	4.9	No	Yes	0	5	9
26	R:R:V246	R:R:W243	58.2217	3.68	No	Yes	0	8	9
27	R:R:V246	R:R:Y269	62.4498	7.57	No	Yes	0	8	7
28	R:R:Y250	R:R:Y269	74.67	3.97	Yes	Yes	0	8	7
29	R:R:R176	R:R:Y250	66.5439	4.12	Yes	Yes	0	9	8
30	R:R:N177	R:R:R176	27.4632	6.03	Yes	Yes	3	9	9
31	R:R:L172	R:R:V409	14.3486	4.47	No	No	0	9	9
32	R:R:H180	R:R:N177	37.2393	3.83	Yes	Yes	3	9	9
33	R:R:I345	R:R:R176	10.3549	3.76	No	Yes	0	5	9
34	R:R:L349	R:R:R176	39.956	6.07	No	Yes	0	9	9
35	R:R:E247	R:R:I179	15.5682	5.47	No	No	0	9	8
36	R:R:I179	R:R:Y250	15.1904	6.04	No	Yes	0	8	8
37	R:R:H180	R:R:Y402	51.8462	17.42	Yes	Yes	3	9	8
38	R:R:W243	R:R:W274	38.6503	18.74	Yes	Yes	8	9	9
39	R:R:C226	R:R:Y220	15.5634	14.79	No	Yes	0	9	3
40	R:R:C226	R:R:C296	17.2805	7.28	No	No	0	9	9
41	R:R:C296	R:R:Q221	18.9879	3.05	No	No	0	9	4
42	R:R:G295	R:R:Q221	22.3742	6.58	No	No	0	4	4
43	R:R:G295	R:R:R227	24.053	3	No	No	0	4	8
44	R:R:R227	R:R:W297	25.5213	16.99	No	Yes	1	8	8
45	R:R:K288	R:R:W297	34.6757	9.28	Yes	Yes	1	8	8
46	R:R:K288	R:R:N300	59.5753	8.39	Yes	No	0	8	6
47	R:R:N300	R:R:W306	61.0245	10.17	No	No	0	6	6
48	R:R:R310	R:R:W306	73.6369	13.99	No	No	0	6	6
49	R:R:E364	R:R:R310	74.9904	8.14	No	No	0	8	6
50	R:R:C317	R:R:E364	78.9937	3.04	No	No	0	7	8
51	R:R:C317	R:R:C361	80.309	7.28	No	No	0	7	9
52	R:R:C361	R:R:F321	89.2481	4.19	No	Yes	0	9	6
53	R:R:F321	R:R:F324	100	3.22	Yes	Yes	0	6	9
54	R:R:F324	R:R:I357	85.9049	6.28	Yes	No	11	9	8
55	R:R:I357	R:R:T353	87.8563	3.04	No	Yes	0	8	9
56	R:R:T353	R:R:Y402	77.3149	6.24	Yes	Yes	0	9	8
57	R:R:W274	R:R:Y235	32.0595	7.72	Yes	No	0	9	9
58	R:R:P277	R:R:Y235	23.0295	2.78	Yes	No	0	9	9
59	R:R:P277	R:R:Y242	13.8177	6.95	Yes	Yes	9	9	6
60	R:R:C361	R:R:N320	10.6706	3.15	No	No	0	9	9
61	R:R:L251	R:R:L349	39.9321	4.15	No	No	0	9	9
62	R:R:A350	R:R:L251	27.3579	3.15	No	No	0	8	9
63	R:R:A350	R:R:L354	26.9514	3.15	No	No	0	8	8
64	R:R:L354	R:R:V327	18.744	5.96	No	No	0	8	9
65	R:R:L255	R:R:V327	17.467	4.47	No	No	0	8	9
66	R:R:I330	R:R:L255	16.1804	4.28	No	No	0	9	8
67	R:R:E292	R:R:K288	15.8791	14.85	No	Yes	0	6	8
68	R:R:E292	R:R:Y305	10.6371	11.22	No	Yes	0	6	4
69	R:R:L307	R:R:W306	14.1525	2.28	Yes	No	0	7	6
70	R:R:N406	R:R:V409	15.6591	7.39	No	No	0	9	9
71	R:R:N406	W:W:?1	13.9325	4.63	No	Yes	0	9	0
72	R:R:I330	R:R:K334	10.9384	2.91	No	No	0	9	9
73	R:R:S352	R:R:Y402	17.9262	6.36	No	Yes	0	9	8
74	R:R:I366	R:R:T362	10.5414	4.56	No	No	0	6	7
75	R:R:F321	R:R:T362	12.2872	2.59	Yes	No	0	6	7
76	R:R:S352	W:W:?1	14.3486	9.11	No	Yes	0	9	0
77	R:R:E247	R:R:Y402	15.5634	13.47	No	Yes	3	9	8
78	R:R:L251	R:R:T353	17.8257	4.42	No	Yes	0	9	9
79	R:R:F324	R:R:L354	22.1446	6.09	Yes	No	0	9	8
80	R:R:H180	R:R:R176	15.6208	4.51	Yes	Yes	3	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V331	W:W:?1	5.02	0	No	Yes	8	0	1	0
R:R:V332	W:W:?1	3.01	0	No	Yes	6	0	1	0
R:R:F347	R:R:K342	21.09	12	No	No	7	5	1	2
R:R:I345	R:R:R348	5.01	0	No	Yes	5	8	2	1
R:R:F347	R:R:K351	6.2	12	No	No	7	8	1	1
R:R:F347	W:W:?1	5.75	12	No	Yes	7	0	1	0
R:R:N407	R:R:R348	10.85	0	No	Yes	6	8	2	1
R:R:E408	R:R:R348	11.63	0	No	Yes	9	8	2	1
R:R:R348	W:W:?1	6.56	0	Yes	Yes	8	0	1	0
R:R:K351	W:W:?1	31.39	12	No	Yes	8	0	1	0
R:R:L401	R:R:S352	3	0	No	No	8	9	2	1
R:R:S352	R:R:Y402	6.36	0	No	Yes	9	8	1	2
R:R:S352	W:W:?1	9.11	0	No	Yes	9	0	1	0
R:R:T355	W:W:?1	11.93	0	No	Yes	8	0	1	0
R:R:V405	W:W:?1	4.02	0	No	Yes	6	0	1	0
R:R:E408	R:R:N406	13.15	0	No	No	9	9	2	1
R:R:N406	R:R:V409	7.39	0	No	No	9	9	1	2
R:R:N406	W:W:?1	4.63	0	No	Yes	9	0	1	0
R:R:L335	R:R:V331	2.98	0	No	No	8	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Single	6KK1	PF-06372222	6KK1-GLP-1-PF-06372222
80.00	Single	5VEW	PF-06372222	5VEW-GLP-1-PF-06372222
77.78	Single	5EE7	MK0893	5EE7-Glucagon-MK0893
70.00	Single	5VEX	NNC0640	5VEX-GLP-1-NNC0640
70.00	Single	6KK7	PF-06372222	6KK7-GLP-1-PF-06372222
60.00	Single	6LN2	PF-06372222	6LN2-GLP-1-PF-06372222
58.33	Single	5XEZ	NNC0640	5XEZ-Glucagon-NNC0640
53.85	Single	5XF1	NNC0640	5XF1-Glucagon-NNC0640
42.86	Single	7E2Y	PtdIns4P	7E2Y-5-HT_1A-Serotonin-PtdIns4P-Gi1/β1/γ2
42.86	Single	8FYT	PtdIns4P	8FYT-5-HT_1A-LSD-PtdIns4P-Gi1/β1/γ1
41.67	Single	9DYD	PtdIns4P	9DYD-5-HT_1A-Asenapine-PtdIns4P-Go/β1/γ2
40.00	Single	8FYX	PtdIns4P	8FYX-5-HT_1A-Buspirone-PtdIns4P-Gi1/β1/γ1
38.46	Single	9DYE	PtdIns4P	9DYE-5-HT_1A-Buspirone-PtdIns4P-Go/β1/γ2
38.46	Single	9MD1	PtdIns4P	9MD1-5-HT_1A-Buspirone-PtdIns4P-Gz/β1/γ2
35.29	Single	9DYF	PtdIns4P	9DYF-5-HT_1A-Asenapine-PtdIns4P-Gi1/β1/γ2
33.33	Single	7E2Z	PtdIns4P	7E2Z-5-HT_1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2
33.33	Single	8FYE	PtdIns4P	8FYE-5-HT_1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1
33.33	Single	8JT6	PtdIns4P	8JT6-5-HT_1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2
31.25	Single	8FY8	PtdIns4P	8FY8-5-HT_1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1
31.25	Single	8FYL	PtdIns4P	8FYL-5-HT_1A-Vilazodone-PtdIns4P-Gi1/β1/γ1
27.78	Single	8TB7	PubChem 168510218	8TB7-GPR61-PubChem 168510218
26.67	Single	9KVH	PtdIns4P	9KVH-5-HT_1A-Cinobufotenine-PtdIns4P-Gi1/β1/γ2
25.00	Single	7E2X	PtdIns4P	7E2X-5-HT_1A-PtdIns4P-Gi1/β1/γ2
25.00	Single	7EB2	rac-BHFF	7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
25.00	Single	9KVG	PtdIns4P	9KVG-5-HT_1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ2
21.43	Single	7CA3	rac-BHFF	7CA3-GABA_B1, GABA_B2-rac-BHFF
20.00	Single	7C7Q	BHFF	7C7Q-GABA_B1, GABA_B2-Baclofen-BHFF
18.75	Single	5X7D	PubChem 129318963	5X7D-β₂-Carazolol-PubChem 129318963
18.18	Single	7DUQ	PubChem 156022738	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
18.18	Single	9KVI	PtdIns4P	9KVI-5-HT_1A-Bufotenin-PtdIns4P-Gi1/β1/γ2
17.65	Single	8JPF	SBI-553	8JPF-NTS₁-Neurotensin-(8-13)-SBI-553
15.38	Single	9L80	Atazanavir	9L80-GPR119-Atazanavir-chim(NtGi1-Gs)/β1/γ2
13.33	Single	5T1A	PubChem 12093170	5T1A-CCR2-BMS-681-PubChem 12093170
12.50	Single	7EJX	(1R;2R)-2-PCCA	7EJX-GPR88-(1R;2R)-2-PCCA-Gi1/β1/γ2
12.50	Single	9L8L	Atazanavir	9L8L-β₂-BI167107-Atazanavir-Gs/β1/γ2 ; Arrestin2
11.76	Single	8XQS	Flufenamic acid	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
11.11	Single	7DUR	PubChem 156022738	7DUR-GLP-1-PubChem 156022738-Gs/β1/γ2
11.11	Single	8JPC	SBI-553; GDP; Mg	8JPC-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
10.53	Single	8GW8	PCO371	8GW8-PTH1-PCO371-Gs/β1/γ2
10.00	Single	7E14	PubChem 156022738	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
10.00	Single	7EVM	PubChem 156022738	7EVM-GLP-1-PubChem 156022738-Gs/β1/γ2
10.00	Single	8JPB	SBI-553; GDP; Mg	8JPB-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
9.52	Single	5LWE	Vercirnon	5LWE-CCR9-Vercirnon
9.52	Single	8JR9	PCO371	8JR9-PTH1-PCO371-chim(NtGi1-Gs)/β1/γ2
9.52	Single	8ZYU	SBI-553	8ZYU-NTS₁-Neurotensin-(8-13)-SBI-553-Arrestin2
9.52	Single	8ZYY	SBI-553	8ZYY-NTS₁-Neurotensin-(8-13)-SBI-553-Arrestin2
8.33	Single	6UO8	GS39783	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
8.33	Single	8ZYT	SBI-553	8ZYT-NTS₁-Neurotensin-(8-13)-SBI-553-Arrestin2
7.69	Single	9L84	Atazanavir	9L84-β₁-Epinephrine-Atazanavir-Gs/β1/γ2
5.88	Single	8XQR	Flufenamic acid	8XQR-TAS2R14-Flufenamic acid-Gt3/β1/γ1
5.56	Single	8RQL	Flufenamic acid	8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
5.56	Single	8XQL	Aristolochic acid A	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.56	Single	8XQO	Aristolochic acid A	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
5.26	Single	8XQL	Aristolochic acid A	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.00	Single	6LFL	PubChem 153466996	6LFL-CXCR2-PubChem 153466996
4.00	Single	8FN0	SBI-553	8FN0-NTS₁-Neurotensin-(8-13)-SBI-553-chim(NtGi1-Go)/β1/γ2

PDB Summary
PDB	6KJV
Class	B1
SubFamily	Peptide
Type	Glucagon
SubType	GLP-1
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	PF-06372222
Protein Partners	-
PDB Resolution	2.8
Date	2019-11-13
D.O.I.	doi.org/10.1107/S2052252519013496

Net Summary
I_min	3
Number of Linked Nodes	243
Number of Links	265
Number of Hubs	30
Number of Links mediated by Hubs	126
Number of Communities	12
Number of Nodes involved in Communities	49
Number of Links involved in Communities	57

Path Summary
Number Of Nodes in MetaPath	81
Number Of Links MetaPath	80
Number of Shortest Paths	41452
Length Of Smallest Path	3
Average Path Length	18.1757
Length of Longest Path	44
Minimum Path Strength	1.435
Average Path Strength	6.16936
Maximum Path Strength	21.66
Minimum Path Correlation	0.7
Average Path Correlation	0.934409
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.43902
Average % Of Corr. Nodes	45.7175
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.6599
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• hydrolase activity, acting on glycosyl bonds • peptidoglycan muralytic activity • hydrolase activity, hydrolyzing O-glycosyl compounds • lysozyme activity • hydrolase activity • catalytic activity • glucagon receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • binding • peptide hormone binding • hormone binding • glucagon-like peptide 1 receptor activity • defense response to bacterium • biological process involved in interspecies interaction between organisms • response to stimulus • response to other organism • defense response • response to bacterium • response to stress • response to external stimulus • response to external biotic stimulus • response to biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process
Gene Ontology	Biological Process	• defense response to bacterium • biological process involved in interspecies interaction between organisms • response to stimulus • response to other organism • defense response • response to bacterium • response to stress • response to external stimulus • response to external biotic stimulus • response to biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process • carbohydrate derivative metabolic process • aminoglycan catabolic process • macromolecule catabolic process • glycosaminoglycan catabolic process • aminoglycan metabolic process • peptidoglycan metabolic process • metabolic process • cellular process • macromolecule metabolic process • symbiont-mediated cytolysis of host cell • viral life cycle • disruption of cell in another organism • cytolysis • biological process involved in interaction with host • biological process involved in symbiotic interaction • viral release from host cell by cytolysis • exit from host cell • viral process • cytolysis in another organism • viral release from host cell • disruption of anatomical structure in another organism • symbiont-mediated killing of host cell • killing of cells of another organism • cell killing • cell wall organization or biogenesis • cell wall macromolecule catabolic process • cell wall macromolecule metabolic process • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • heart process • multicellular organismal process • system process • regulation of biological process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • regulation of blood pressure • positive regulation of blood pressure • cellular response to stimulus • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • response to psychosocial stress • cell surface receptor signaling pathway • behavior • learning or memory • nervous system process • cognition • transport • secretion • regulation of hormone levels • cell-cell signaling • export from cell • hormone secretion • establishment of localization • localization • secretion by cell • signal release • hormone transport • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • establishment of protein localization • cellular localization • protein targeting • protein transmembrane transport • establishment of localization in cell • post-translational protein targeting to membrane, translocation • intracellular protein localization • establishment of protein localization to endoplasmic reticulum • establishment of protein localization to membrane • intracellular protein transmembrane transport • intracellular transport • post-translational protein targeting to endoplasmic reticulum membrane • localization within membrane • protein targeting to membrane • transmembrane transport • establishment of protein localization to organelle • protein transport • macromolecule localization • intracellular protein transport • protein targeting to ER • negative regulation of blood pressure • host cellular component • host intracellular part • cellular anatomical structure • host cell cytoplasm • host cell part • host intracellular region • other organism part • membrane • cell periphery • plasma membrane
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	97Y
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	97Y
Name	N-{4-[(R)-(3,3-dimethylcyclobutyl)({6-[4-(trifluoromethyl)-1H-imidazol-1-yl]pyridin-3-yl}amino)methyl]benzene-1-carbonyl}-beta-alanine
Synonyms
Identifier
Formula	C26 H28 F3 N5 O3
Molecular Weight	515.527
SMILES
PubChem	68178630
Formal Charge	0
Total Atoms	65
Total Chiral Atoms	1
Total Bonds	68
Total Aromatic Bonds	17


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43220
Sequence	>6KJV_Chain_R S P E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F R H L H C T R N Y I H L N L F A S F I L R A L C V F F K D A A L K W G L L S Y Q D S L A C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V A I G W G V P L L F V V P W G I V K Y L Y E D E G C W T R N S N M N Y W L I I R L P I L F A C I V N F L I F V R V I C I V V S K L K A N L M C K T D I A F R L A K S T L T L I P L L C T H E V I F A F V M R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E V Q L E F R K S W E R W R L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5VEX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	NNC0640	-	3	2017-05-17	doi.org/10.1038/nature22378
	5VAI	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-	Gs/β1/γ2	4.1	2017-05-24	doi.org/10.1038/nature22394
	5VAI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-		4.1	2017-05-24	doi.org/10.1038/nature22394
	5VEW	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.7	2017-05-24	doi.org/10.1038/nature22378
	5NX2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	-	3.7	2017-06-14	doi.org/10.1038/nature22800
	6B3J	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-	Gs/β1/γ2	3.3	2018-02-21	doi.org/10.1038/nature25773
	6B3J (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-		3.3	2018-02-21	doi.org/10.1038/nature25773
	6KJV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.1	2019-11-13	doi.org/10.1107/S2052252519013496
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	6LN2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.2	2020-03-18	doi.org/10.1038/s41467-020-14934-5
	6VCB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440	Gs/β1/γ2	3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	6VCB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440		3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	7C2E	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-	Gs/β1/γ2	4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	7C2E (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-		4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	6X18	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X18 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6XOX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-	chim(NtGi1-Gs)/β1/γ2	3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	6XOX (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-		3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	7LCI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCJ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	2.82	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCK	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	3.24	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7E14	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738	Gs/β1/γ2	2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7E14 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738		2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7DUQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738	Gs/β1/γ2	2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DUQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738		2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7KI0	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI0 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7DUR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7DUR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7RTB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-	Gs/β1/γ2	2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7RTB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-		2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7S1M	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4-D-Ala	-	Gs/β1/γ2	2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S1M (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4-D-Ala	-		2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7LLL	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLL (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-	Gs/β1/γ2	3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-		3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7FIM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide (non-acylated)	-	Gs/β1/γ2	3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide (non-acylated)	-		3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBH	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7VBH (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-		3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7RG9	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RG9 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7S15	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 134611223	-	-	3.8	2022-06-08	doi.org/10.1021/acs.jmedchem.1c01856
	7X8R	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-	Gs/β1/γ2	2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8R (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-		2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-	Gs/β1/γ2	3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-		3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	8JIP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-	chim(NtGi1-Gs)/β1/γ2	2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-		2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-	chim(NtGi1-Gs)/β1/γ2	2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-		2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIS	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-	chim(NtGi1-Gs)/β1/γ2	2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8JIS (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-		2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8YW3	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	9J1P	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-	chim(NtGi1-Gs)/β1/γ2	2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	9J1P (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-		2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	8WG7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WG7 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	9IVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839	chim(NtGi1-Gs)/β2/γ2	3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	9IVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839		3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	9IVG	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	chim(NtGi1-Gs)/β1/γ2	3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	9IVG (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-		3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	9EBN	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBN (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-	Gs/β1/γ2	3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-		3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	8YWF	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ2	2.74	2025-04-16	To be published
	8YWF (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.74	2025-04-16	To be published
	9BYO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-	Gs/β1/γ2	2.31	2025-06-11	To be published
	9BYO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-		2.31	2025-06-11	To be published
	9C0K	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	2.72	2025-06-11	To be published
	9C0K (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		2.72	2025-06-11	To be published
	9E2A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	3.3	2025-10-29	To be published
	9E2A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		3.3	2025-10-29	To be published

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Data downloads are temporarily suspended for technical reasons. We apologize for the inconvenience.

Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.