psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W33	7.71	Yes	Yes	1	0	3
2	L:L:?1	R:R:E34	4.49	Yes	No	0	0	4
3	L:L:?1	R:R:P137	11.12	Yes	No	0	0	3
4	L:L:?1	R:R:E138	10.47	Yes	Yes	1	0	2
5	L:L:?1	R:R:L141	7.81	Yes	No	0	0	5
6	L:L:?1	R:R:L144	5.47	Yes	No	1	0	6
7	L:L:?1	R:R:Y145	11.9	Yes	Yes	1	0	5
8	L:L:?1	R:R:Y148	8.6	Yes	Yes	1	0	7
9	L:L:?1	R:R:K197	16.71	Yes	No	1	0	6
10	L:L:?1	R:R:D198	5.36	Yes	No	1	0	7
11	L:L:?1	R:R:L201	7.81	Yes	No	1	0	7
12	L:L:?1	R:R:K202	6.36	Yes	No	0	0	4
13	L:L:?1	R:R:Y205	6.61	Yes	Yes	1	0	3
14	L:L:?1	R:R:Y220	5.95	Yes	Yes	1	0	3
15	L:L:?1	R:R:C226	4.48	Yes	No	1	0	9
16	L:L:?1	R:R:V229	4.2	Yes	No	1	0	7
17	L:L:?1	R:R:F230	10.31	Yes	Yes	1	0	5
18	L:L:?1	R:R:M233	4.79	Yes	Yes	1	0	6
19	L:L:?1	R:R:T298	9.98	Yes	No	1	0	5
20	R:R:S135	R:R:T29	6.4	No	No	0	1	2
21	R:R:E34	R:R:V30	4.28	No	No	0	4	2
22	R:R:E34	R:R:S31	7.19	No	No	0	4	4
23	R:R:P137	R:R:S31	3.56	No	No	0	3	4
24	R:R:L32	R:R:Y205	14.07	No	Yes	0	4	3
25	R:R:Q37	R:R:W33	4.38	Yes	Yes	1	4	3
26	R:R:Q221	R:R:W33	15.33	Yes	Yes	1	4	3
27	R:R:T298	R:R:W33	8.49	No	Yes	1	5	3
28	R:R:P90	R:R:T35	10.49	No	No	0	4	5
29	R:R:R40	R:R:V36	6.54	No	No	0	2	2
30	R:R:V36	R:R:W214	7.36	No	Yes	0	2	1
31	R:R:L217	R:R:V36	5.96	No	No	0	4	2
32	R:R:Q221	R:R:Q37	7.68	Yes	Yes	1	4	4
33	R:R:E294	R:R:Q37	3.82	Yes	Yes	1	4	4
34	R:R:G295	R:R:Q37	4.93	No	Yes	1	4	4
35	R:R:K38	R:R:W87	10.44	No	No	0	4	3
36	R:R:R43	R:R:W39	16.99	No	Yes	0	4	5
37	R:R:E68	R:R:W39	5.45	No	Yes	0	4	5
38	R:R:W39	R:R:Y88	16.4	Yes	No	0	5	5
39	R:R:W214	R:R:W39	12.18	Yes	Yes	0	1	5
40	R:R:L218	R:R:R40	13.36	No	No	0	3	2
41	R:R:Q221	R:R:R40	8.18	Yes	No	0	4	2
42	R:R:F66	R:R:Y42	4.13	No	No	0	7	6
43	R:R:P86	R:R:Y42	5.56	Yes	No	0	8	6
44	R:R:W87	R:R:Y42	9.65	No	No	0	3	6
45	R:R:F66	R:R:R43	6.41	No	No	0	7	4
46	R:R:Q45	R:R:W87	4.38	No	No	0	5	3
47	R:R:C46	R:R:F66	6.98	No	No	0	8	7
48	R:R:C46	R:R:C71	7.28	No	No	7	8	9
49	R:R:L50	R:R:R64	4.86	No	No	0	4	4
50	R:R:D53	R:R:P54	4.83	No	No	0	3	2
51	R:R:D53	R:R:R64	11.91	No	No	0	3	4
52	R:R:F61	R:R:P56	5.78	Yes	No	8	3	1
53	R:R:D74	R:R:P56	9.66	No	No	8	3	1
54	R:R:F61	R:R:T58	5.19	Yes	No	0	3	1
55	R:R:D74	R:R:F61	13.14	No	Yes	8	3	3
56	R:R:E76	R:R:F61	4.66	No	Yes	0	1	3
57	R:R:C62	R:R:G75	3.92	No	No	2	9	7
58	R:R:C104	R:R:C62	3.64	No	No	0	9	9
59	R:R:C62	R:R:W110	15.67	No	Yes	2	9	9
60	R:R:D67	R:R:W72	13.4	No	Yes	2	9	9
61	R:R:D67	R:R:R102	5.96	No	Yes	2	9	8
62	R:R:D67	R:R:R121	8.34	No	Yes	2	9	6
63	R:R:P86	R:R:Y69	13.91	Yes	Yes	2	8	6
64	R:R:L89	R:R:Y69	4.69	Yes	Yes	2	5	6
65	R:R:R121	R:R:Y69	6.17	Yes	Yes	2	6	6
66	R:R:L123	R:R:Y69	9.38	No	Yes	2	5	6
67	R:R:A70	R:R:W72	3.89	No	Yes	0	5	9
68	R:R:V81	R:R:W72	4.9	No	Yes	0	6	9
69	R:R:V83	R:R:W72	3.68	No	Yes	0	5	9
70	R:R:V100	R:R:W72	8.58	No	Yes	0	7	9
71	R:R:R102	R:R:W72	13.99	Yes	Yes	2	8	9
72	R:R:R121	R:R:W72	4	Yes	Yes	2	6	9
73	R:R:P73	R:R:V81	3.53	No	No	0	5	6
74	R:R:G75	R:R:W110	4.22	No	Yes	2	7	9
75	R:R:E76	R:R:S79	10.06	No	No	0	1	5
76	R:R:G108	R:R:P77	4.06	No	No	0	9	4
77	R:R:F103	R:R:F80	17.15	No	No	0	4	4
78	R:R:V81	R:R:W110	4.9	No	Yes	0	6	9
79	R:R:C85	R:R:P86	3.77	No	Yes	2	9	8
80	R:R:C126	R:R:C85	5.46	No	No	2	9	9
81	R:R:P86	R:R:Y88	5.56	Yes	No	2	8	5
82	R:R:L89	R:R:P86	11.49	Yes	Yes	2	5	8
83	R:R:L89	R:R:Y88	9.38	Yes	No	2	5	5
84	R:R:L89	R:R:W91	14.81	Yes	No	0	5	4
85	R:R:P90	R:R:W91	6.76	No	No	0	4	4
86	R:R:C126	R:R:V95	5.12	No	No	0	9	5
87	R:R:H99	R:R:Y101	6.53	No	Yes	0	4	5
88	R:R:E125	R:R:Y101	11.22	No	Yes	0	5	5
89	R:R:R102	R:R:W110	9	Yes	Yes	2	8	9
90	R:R:P119	R:R:R102	4.32	No	Yes	0	6	8
91	R:R:R102	R:R:R121	12.79	Yes	Yes	2	8	6
92	R:R:L111	R:R:W120	4.56	No	No	0	4	5
93	R:R:D114	R:R:S117	8.83	No	No	0	4	7
94	R:R:D122	R:R:W120	5.58	No	No	0	7	5
95	R:R:L123	R:R:R121	3.64	No	Yes	2	5	6
96	R:R:D122	R:R:S124	4.42	No	No	0	7	5
97	R:R:P137	R:R:S136	3.56	No	No	0	3	1
98	R:R:E138	R:R:S136	10.06	Yes	No	0	2	1
99	R:R:E138	R:R:E139	3.81	Yes	No	0	2	2
100	R:R:E138	R:R:Y205	8.98	Yes	Yes	1	2	3
101	R:R:L141	R:R:Q140	11.98	No	No	0	5	4
102	R:R:F385	R:R:L141	3.65	No	No	0	6	5
103	R:R:F143	R:R:I147	11.3	No	No	0	4	6
104	R:R:L144	R:R:Y148	4.69	No	Yes	1	6	7
105	R:R:F385	R:R:L144	12.18	No	No	0	6	6
106	R:R:Y145	R:R:Y148	3.97	Yes	Yes	1	5	7
107	R:R:T149	R:R:Y145	8.74	No	Yes	0	7	5
108	R:R:D198	R:R:Y145	10.34	No	Yes	1	7	5
109	R:R:Y148	R:R:Y152	3.97	Yes	Yes	0	7	7
110	R:R:G151	R:R:S392	3.71	No	No	9	8	9
111	R:R:F393	R:R:G151	9.03	No	No	9	7	8
112	R:R:V194	R:R:Y152	12.62	No	Yes	0	7	7
113	R:R:S392	R:R:Y152	5.09	No	Yes	0	9	7
114	R:R:L154	R:R:L396	4.15	No	No	0	5	7
115	R:R:F156	R:R:V160	3.93	Yes	No	0	7	3
116	R:R:F156	R:R:I188	7.54	Yes	No	0	7	7
117	R:R:F156	R:R:L192	7.31	Yes	No	0	7	3
118	R:R:F184	R:R:L159	6.09	No	No	0	8	9
119	R:R:I188	R:R:L159	5.71	No	No	0	7	9
120	R:R:F404	R:R:I161	3.77	Yes	No	0	8	4
121	R:R:A162	R:R:C403	3.61	No	Yes	0	9	9
122	R:R:F184	R:R:S163	3.96	No	No	0	8	6
123	R:R:C403	R:R:I165	4.91	Yes	No	0	9	8
124	R:R:F413	R:R:I165	7.54	No	No	0	5	8
125	R:R:L166	R:R:L181	8.3	No	No	0	8	6
126	R:R:F169	R:R:L172	6.09	Yes	Yes	0	7	9
127	R:R:E412	R:R:F169	12.83	No	Yes	0	8	7
128	R:R:F169	R:R:F413	12.86	Yes	No	0	7	5
129	R:R:F169	R:R:S416	5.28	Yes	No	0	7	5
130	R:R:H173	R:R:R170	9.03	No	No	0	7	8
131	R:R:E412	R:R:H171	19.69	No	No	0	8	7
132	R:R:L172	R:R:N177	4.12	Yes	Yes	0	9	9
133	R:R:E408	R:R:L172	3.98	No	Yes	0	9	9
134	R:R:L172	R:R:V409	5.96	Yes	No	0	9	9
135	R:R:H173	R:R:Y178	11.98	No	No	0	7	6
136	R:R:C174	R:R:R176	5.57	No	Yes	6	8	9
137	R:R:C174	R:R:N177	6.3	No	Yes	6	8	9
138	R:R:T175	R:R:Y250	9.99	No	No	0	7	8
139	R:R:N177	R:R:R176	4.82	Yes	Yes	6	9	9
140	R:R:H180	R:R:R176	4.51	Yes	Yes	6	9	9
141	R:R:E408	R:R:R176	4.65	No	Yes	0	9	9
142	R:R:H180	R:R:N177	5.1	Yes	Yes	6	9	9
143	R:R:F266	R:R:Y178	7.22	No	No	0	6	6
144	R:R:E247	R:R:I179	6.83	No	No	0	9	8
145	R:R:I179	R:R:Y269	3.63	No	Yes	0	8	7
146	R:R:E247	R:R:H180	9.85	No	Yes	0	9	9
147	R:R:H180	R:R:Y402	7.62	Yes	No	0	9	8
148	R:R:N182	R:R:W243	15.82	No	Yes	11	9	9
149	R:R:N182	R:R:V270	4.43	No	No	0	9	5
150	R:R:N182	R:R:W274	5.65	No	Yes	11	9	9
151	R:R:F187	R:R:L183	6.09	Yes	No	3	8	9
152	R:R:L183	R:R:L244	6.92	No	No	3	9	9
153	R:R:F184	R:R:V398	3.93	No	No	0	8	9
154	R:R:N240	R:R:S186	7.45	No	No	0	9	9
155	R:R:S186	R:R:W243	7.41	No	Yes	0	9	9
156	R:R:F187	R:R:N240	20.54	Yes	No	0	8	9
157	R:R:F187	R:R:L244	3.65	Yes	No	3	8	9
158	R:R:F187	R:R:Q394	11.71	Yes	No	3	8	9
159	R:R:F187	R:R:G395	6.02	Yes	No	0	8	9
160	R:R:C236	R:R:L189	7.94	No	No	0	5	7
161	R:R:R190	R:R:V237	7.85	Yes	No	0	8	6
162	R:R:N240	R:R:R190	10.85	No	Yes	0	9	8
163	R:R:R190	R:R:Y241	12.35	Yes	Yes	0	8	8
164	R:R:R190	R:R:T391	5.17	Yes	No	0	8	6
165	R:R:M233	R:R:S193	7.67	Yes	No	0	6	6
166	R:R:K197	R:R:M233	4.32	No	Yes	1	6	6
167	R:R:L201	R:R:Y205	4.69	No	Yes	1	7	3
168	R:R:T207	R:R:W203	3.64	No	No	0	3	3
169	R:R:M204	R:R:Y220	3.59	No	Yes	0	3	3
170	R:R:A209	R:R:Q210	4.55	No	No	0	1	4
171	R:R:Q211	R:R:Q213	11.52	No	No	0	4	4
172	R:R:Q211	R:R:W214	8.76	No	Yes	0	4	1
173	R:R:H212	R:R:W214	7.41	No	Yes	0	3	1
174	R:R:D215	R:R:Q213	9.14	No	No	0	3	4
175	R:R:G216	R:R:S219	3.71	No	No	0	2	5
176	R:R:L217	R:R:Q221	7.99	No	Yes	0	4	4
177	R:R:S223	R:R:Y220	3.82	No	Yes	0	4	3
178	R:R:C226	R:R:Y220	14.79	No	Yes	1	9	3
179	R:R:L224	R:R:L228	4.15	No	No	0	3	4
180	R:R:L224	R:R:Y289	4.69	No	No	0	3	3
181	R:R:C226	R:R:C296	5.46	No	No	0	9	9
182	R:R:C296	R:R:R227	8.36	No	No	0	9	8
183	R:R:R227	R:R:W297	19.99	No	Yes	0	8	8
184	R:R:M233	R:R:V229	4.56	Yes	No	1	6	7
185	R:R:F230	R:R:Q234	9.37	Yes	No	1	5	7
186	R:R:F230	R:R:W284	5.01	Yes	Yes	1	5	8
187	R:R:F230	R:R:W297	4.01	Yes	Yes	1	5	8
188	R:R:L231	R:R:W297	6.83	No	Yes	0	5	8
189	R:R:Q234	R:R:W284	6.57	No	Yes	1	7	8
190	R:R:W274	R:R:Y235	6.75	Yes	No	0	9	9
191	R:R:P277	R:R:Y235	4.17	No	No	0	9	9
192	R:R:L278	R:R:Y235	8.21	No	No	0	3	9
193	R:R:I313	R:R:Y241	10.88	No	Yes	0	7	8
194	R:R:I317	R:R:Y241	4.84	No	Yes	3	7	8
195	R:R:E364	R:R:Y241	13.47	No	Yes	3	8	8
196	R:R:L245	R:R:Y242	4.69	No	Yes	5	8	6
197	R:R:V276	R:R:Y242	6.31	No	Yes	0	3	6
198	R:R:F280	R:R:Y242	7.22	Yes	Yes	5	5	6
199	R:R:P312	R:R:Y242	4.17	No	Yes	5	8	6
200	R:R:A316	R:R:Y242	4	No	Yes	5	7	6
201	R:R:V246	R:R:W243	7.36	No	Yes	0	8	9
202	R:R:G273	R:R:W243	11.26	No	Yes	0	9	9
203	R:R:W243	R:R:W274	26.24	Yes	Yes	11	9	9
204	R:R:L244	R:R:Q394	7.99	No	No	3	9	9
205	R:R:A316	R:R:L245	6.3	No	No	5	7	8
206	R:R:L245	R:R:N320	8.24	No	No	0	8	9
207	R:R:V246	R:R:Y269	5.05	No	Yes	0	8	7
208	R:R:E247	R:R:L359	9.28	No	No	0	9	9
209	R:R:G248	R:R:I323	3.53	No	No	0	8	8
210	R:R:V249	R:R:Y269	6.31	No	Yes	0	6	7
211	R:R:L254	R:R:Y250	15.24	No	No	0	8	8
212	R:R:Y250	R:R:Y269	9.93	No	Yes	0	8	7
213	R:R:L251	R:R:L255	5.54	No	No	4	9	8
214	R:R:L251	R:R:V327	5.96	No	No	4	9	9
215	R:R:A256	R:R:Y252	8.01	No	Yes	0	6	8
216	R:R:F257	R:R:Y252	6.19	No	Yes	0	5	8
217	R:R:I323	R:R:Y252	4.84	No	Yes	0	8	8
218	R:R:F257	R:R:T253	5.19	No	No	0	5	7
219	R:R:T253	R:R:Y269	4.99	No	Yes	0	7	7
220	R:R:L255	R:R:V327	4.47	No	No	4	8	9
221	R:R:I265	R:R:L260	4.28	No	No	0	5	7
222	R:R:S261	R:R:W264	7.41	No	No	0	7	5
223	R:R:Q263	R:R:R267	5.84	No	No	0	5	4
224	R:R:I265	R:R:W264	4.7	No	No	0	5	5
225	R:R:I265	R:R:Y269	9.67	No	Yes	0	5	7
226	R:R:F266	R:R:V270	5.24	No	No	0	6	5
227	R:R:I272	R:R:L268	7.14	No	No	0	6	2
228	R:R:I272	R:R:V276	4.61	No	No	0	6	3
229	R:R:P277	R:R:V276	3.53	No	No	0	9	3
230	R:R:F280	R:R:V281	3.93	Yes	No	0	5	6
231	R:R:F280	R:R:P312	18.78	Yes	No	5	5	8
232	R:R:I309	R:R:V281	6.14	No	No	0	7	6
233	R:R:P283	R:R:V282	3.53	No	No	0	5	3
234	R:R:G285	R:R:W284	7.04	No	Yes	1	5	8
235	R:R:W284	R:R:W297	4.69	Yes	Yes	1	8	8
236	R:R:I308	R:R:W284	7.05	No	Yes	0	8	8
237	R:R:I309	R:R:W284	17.62	No	Yes	0	7	8
238	R:R:G285	R:R:W297	5.63	No	Yes	1	5	8
239	R:R:V287	R:R:Y291	3.79	No	No	1	4	3
240	R:R:V287	R:R:Y305	5.05	No	Yes	1	4	4
241	R:R:I308	R:R:V287	4.61	No	No	0	8	4
242	R:R:E292	R:R:K288	4.05	No	Yes	1	6	8
243	R:R:K288	R:R:W297	11.6	Yes	Yes	1	8	8
244	R:R:K288	R:R:Y305	7.17	Yes	Yes	1	8	4
245	R:R:D293	R:R:Y289	13.79	No	No	0	7	3
246	R:R:W297	R:R:Y289	6.75	Yes	No	0	8	3
247	R:R:Y291	R:R:Y305	6.95	No	Yes	1	3	4
248	R:R:E292	R:R:S301	4.31	No	No	0	6	3
249	R:R:E292	R:R:Y305	5.61	No	Yes	1	6	4
250	R:R:E294	R:R:G295	6.55	Yes	No	1	4	4
251	R:R:E294	R:R:R299	9.3	Yes	No	0	4	4
252	R:R:N302	R:R:N304	4.09	No	No	0	5	3
253	R:R:N302	R:R:Y305	13.96	No	Yes	0	5	4
254	R:R:I313	R:R:R310	8.77	No	No	0	7	6
255	R:R:L314	R:R:R310	10.93	No	No	0	4	6
256	R:R:F315	R:R:V319	7.87	No	No	0	4	6
257	R:R:E364	R:R:I317	10.93	No	No	3	8	7
258	R:R:F321	R:R:V325	5.24	No	No	0	6	5
259	R:R:F321	R:R:V365	14.42	No	No	0	6	6
260	R:R:F324	R:R:I328	10.05	Yes	No	4	9	7
261	R:R:F324	R:R:T353	3.89	Yes	No	4	9	9
262	R:R:F324	R:R:L356	8.53	Yes	No	4	9	9
263	R:R:F324	R:R:I357	3.77	Yes	No	4	9	8
264	R:R:F324	R:R:L360	3.65	Yes	No	4	9	9
265	R:R:F324	R:R:T362	14.27	Yes	No	4	9	7
266	R:R:I330	R:R:R326	10.02	No	No	0	9	8
267	R:R:I328	R:R:T353	4.56	No	No	4	7	9
268	R:R:L349	R:R:V332	4.47	No	No	0	9	6
269	R:R:I345	R:R:L335	5.71	No	No	0	5	8
270	R:R:L335	R:R:R348	4.86	No	No	0	8	8
271	R:R:C347	W:W:?1	22.38	No	No	0	7	0
272	R:R:K351	R:R:R348	12.38	No	No	0	8	8
273	R:R:R348	R:R:S352	11.86	No	No	0	8	9
274	R:R:K351	R:R:T355	6.01	No	No	0	8	8
275	R:R:L401	R:R:T355	5.9	No	No	0	8	8
276	R:R:T355	R:R:Y402	3.75	No	No	0	8	8
277	R:R:L356	R:R:L360	6.92	No	No	4	9	9
278	R:R:I357	R:R:T362	9.12	No	No	4	8	7
279	R:R:M397	R:R:P358	5.03	No	No	0	5	9
280	R:R:L401	R:R:P358	4.93	No	No	0	8	9
281	R:R:L359	R:R:L360	4.15	No	No	0	9	9
282	R:R:L359	R:R:Y402	21.1	No	No	0	9	8
283	R:R:G361	R:R:H363	4.77	No	Yes	0	9	8
284	R:R:E364	R:R:H363	8.62	No	Yes	3	8	8
285	R:R:F367	R:R:H363	12.44	Yes	Yes	3	7	8
286	R:R:F390	R:R:H363	4.53	No	Yes	3	6	8
287	R:R:H363	R:R:Q394	11.13	Yes	No	3	8	9
288	R:R:F367	R:R:T386	3.89	Yes	No	0	7	4
289	R:R:E387	R:R:F367	9.33	No	Yes	0	8	7
290	R:R:F367	R:R:F390	5.36	Yes	No	3	7	6
291	R:R:L384	R:R:R380	3.64	No	No	0	5	5
292	R:R:F381	R:R:F385	18.22	No	No	0	4	6
293	R:R:F393	R:R:S392	6.61	No	No	9	7	9
294	R:R:I400	R:R:L396	7.14	No	No	0	6	7
295	R:R:F404	R:R:I400	6.28	Yes	No	0	8	6
296	R:R:C403	R:R:F404	5.59	Yes	Yes	0	9	8
297	R:R:E408	R:R:N406	5.26	No	No	0	9	9
298	R:R:N406	R:R:V409	7.39	No	No	0	9	9
299	R:R:Q410	R:R:R414	5.84	No	No	0	7	6
300	R:R:K415	R:R:R419	6.19	No	No	0	7	7
301	R:R:W417	R:R:W420	5.62	No	No	0	5	4
302	R:R:R421	R:R:W417	6	No	No	0	4	5
303	R:R:E418	R:R:R421	9.3	No	No	0	4	4
304	R:R:E418	R:R:L422	5.3	No	No	0	4	4
305	R:R:G275	R:R:L278	3.42	No	No	0	6	3
306	R:R:E125	R:R:G98	3.27	No	No	0	5	4
307	R:R:S352	R:R:V331	3.23	No	No	0	9	8
308	R:R:F156	R:R:F195	3.22	Yes	No	10	7	7
309	R:R:F413	R:R:R414	3.21	No	No	0	5	6
310	R:R:T29	R:R:V30	3.17	No	No	0	2	2
311	R:R:C46	R:R:L50	3.17	No	No	7	8	4
312	R:R:C71	R:R:L50	3.17	No	No	7	9	4
313	R:R:C403	R:R:L166	3.17	Yes	No	0	9	8
314	R:R:A399	R:R:L159	3.15	No	No	0	8	9
315	R:R:E76	R:R:P77	3.14	No	No	0	1	4
316	R:R:R326	R:R:Y252	3.09	No	Yes	0	8	8
317	R:R:I286	R:R:V282	3.07	No	No	0	4	3
318	R:R:I323	R:R:V319	3.07	No	No	0	8	6
319	R:R:I382	R:R:T386	3.04	No	No	0	4	4
320	R:R:F80	R:R:W120	3.01	No	No	0	4	5
321	R:R:L181	R:R:S163	3	No	No	0	6	6
322	R:R:L154	R:R:V150	2.98	No	No	0	5	5
323	R:R:L278	R:R:V282	2.98	No	No	0	3	3
324	R:R:L356	R:R:V327	2.98	No	No	4	9	9
325	R:R:L349	R:R:V331	2.98	No	No	0	9	8
326	R:R:L111	R:R:T105	2.95	No	No	0	4	4
327	R:R:I330	R:R:K334	2.91	No	No	0	9	9
328	R:R:I345	R:R:K336	2.91	No	No	0	5	6
329	R:R:I286	R:R:L290	2.85	No	No	0	4	3
330	R:R:K415	R:R:L411	2.82	No	No	0	7	4
331	R:R:H99	R:R:S84	2.79	No	No	0	4	4
332	R:R:A191	R:R:F156	2.77	No	Yes	10	7	7
333	R:R:A158	R:R:F404	2.77	No	Yes	0	7	8
334	R:R:L167	R:R:L181	2.77	No	No	0	3	6
335	R:R:A191	R:R:F195	2.77	No	No	10	7	7
336	R:R:A238	R:R:F280	2.77	No	Yes	0	6	5
337	R:R:L384	R:R:L388	2.77	No	No	0	5	7
338	R:R:E412	R:R:K415	2.7	No	No	0	8	7
339	L:L:?1	R:R:A200	2.67	Yes	No	0	0	4
340	R:R:E387	R:R:L388	2.65	No	No	0	8	7
341	R:R:F390	R:R:S389	2.64	No	No	0	6	5
342	R:R:N407	R:R:Q410	2.64	No	No	0	6	7
343	R:R:A185	R:R:W274	2.59	No	Yes	0	3	9
344	R:R:A208	R:R:W214	2.59	No	Yes	0	4	1
345	R:R:A239	R:R:W274	2.59	No	Yes	0	8	9
346	R:R:E294	R:R:E41	2.54	Yes	No	0	4	4
347	R:R:E127	R:R:E128	2.54	No	No	0	2	3
348	R:R:S155	R:R:Y152	2.54	No	Yes	0	9	7
349	R:R:S225	R:R:Y220	2.54	No	Yes	0	3	3
350	R:R:F367	R:R:I366	2.51	Yes	No	0	7	6
351	R:R:L354	W:W:?1	2.44	No	No	0	8	0
352	R:R:I309	R:R:W306	2.35	No	No	0	7	6
353	R:R:E52	R:R:R48	2.33	No	No	0	2	4
354	R:R:N82	R:R:Y101	2.33	No	Yes	0	4	5
355	R:R:M204	R:R:W203	2.33	No	No	0	3	3
356	R:R:D122	R:R:Y101	2.3	No	Yes	0	7	5
357	R:R:L189	R:R:W274	2.28	No	Yes	0	7	9
358	R:R:C85	R:R:G98	1.96	No	No	2	9	4
359	R:R:C126	R:R:G98	1.96	No	No	2	9	4
360	R:R:C104	R:R:G108	1.96	No	No	0	9	9
361	R:R:P54	R:R:P55	1.95	No	No	0	2	1
362	R:R:P55	R:R:P56	1.95	No	No	0	1	1
363	R:R:G78	R:R:S79	1.86	No	No	0	7	5
364	R:R:P96	R:R:V95	1.77	No	No	0	3	5
365	R:R:C329	R:R:V325	1.71	No	No	0	7	5
366	R:R:A57	R:R:T58	1.68	No	No	0	1	1
367	R:R:L118	R:R:P119	1.64	No	No	0	4	6
368	R:R:L311	R:R:P312	1.64	No	No	0	4	8
369	R:R:S93	R:R:S94	1.63	No	No	0	3	4
370	R:R:C236	R:R:L232	1.59	No	No	0	5	5
371	R:R:A92	R:R:L89	1.58	No	Yes	0	5	5
372	R:R:A368	R:R:L314	1.58	No	No	0	6	4
373	R:R:I272	R:R:S271	1.55	No	No	0	6	3
374	R:R:I146	R:R:V150	1.54	No	No	0	4	5
375	R:R:I317	R:R:V365	1.54	No	No	0	7	6
376	R:R:I366	R:R:V365	1.54	No	No	0	6	6
377	R:R:I400	R:R:V405	1.54	No	No	0	6	6
378	R:R:K202	R:R:S206	1.53	No	No	0	4	4
379	R:R:F321	R:R:G318	1.51	No	No	0	6	4
380	R:R:G377	R:R:R380	1.5	No	No	0	4	5
381	R:R:L109	R:R:T105	1.47	No	No	0	5	4
382	R:R:L379	R:R:T378	1.47	No	No	0	3	2
383	R:R:E107	R:R:T105	1.41	No	No	0	5	4
384	R:R:K113	R:R:L111	1.41	No	No	0	4	4
385	R:R:E262	R:R:T175	1.41	No	No	0	6	7
386	R:R:K288	R:R:N300	1.4	Yes	No	0	8	6
387	R:R:A153	R:R:F195	1.39	No	No	0	6	7
388	R:R:D114	R:R:K113	1.38	No	No	0	4	4
389	R:R:L307	R:R:L311	1.38	No	No	0	7	4
390	R:R:D222	R:R:L218	1.36	No	No	0	6	3
391	R:R:E387	R:R:K383	1.35	No	No	0	8	7
392	R:R:E139	R:R:L142	1.33	No	No	0	2	3
393	R:R:F393	R:R:I147	1.26	No	No	0	7	6
394	R:R:Q45	R:R:R44	1.17	No	No	0	5	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.64	20	1	0
2	R:R:W33	8.9775	4	1	3
3	R:R:Q37	5.2025	4	1	4
4	R:R:W39	12.755	4	0	5
5	R:R:F61	7.1925	4	8	3
6	R:R:Y69	8.5375	4	2	6
7	R:R:W72	7.49143	7	2	9
8	R:R:P86	8.058	5	2	8
9	R:R:L89	8.39	5	2	5
10	R:R:Y101	5.595	4	0	5
11	R:R:R102	9.212	5	2	8
12	R:R:W110	8.4475	4	2	9
13	R:R:R121	6.988	5	2	6
14	R:R:E138	8.33	4	1	2
15	R:R:Y145	8.7375	4	1	5
16	R:R:Y148	5.3075	4	1	7
17	R:R:Y152	6.055	4	0	7
18	R:R:F156	4.954	5	10	7
19	R:R:F169	9.265	4	0	7
20	R:R:L172	5.0375	4	0	9
21	R:R:R176	4.8875	4	6	9
22	R:R:N177	5.085	4	6	9
23	R:R:H180	6.77	4	6	9
24	R:R:F187	9.602	5	3	8
25	R:R:R190	9.055	4	0	8
26	R:R:Y205	8.5875	4	1	3
27	R:R:W214	7.66	5	0	1
28	R:R:Y220	6.138	5	1	3
29	R:R:Q221	9.795	4	1	4
30	R:R:F230	7.175	4	1	5
31	R:R:M233	5.335	4	1	6
32	R:R:Y241	10.385	4	3	8
33	R:R:Y242	5.278	5	5	6
34	R:R:W243	13.618	5	11	9
35	R:R:Y252	5.5325	4	0	8
36	R:R:Y269	6.59667	6	0	7
37	R:R:W274	7.68333	6	11	9
38	R:R:F280	8.175	4	5	5
39	R:R:W284	7.99667	6	1	8
40	R:R:K288	6.055	4	1	8
41	R:R:E294	5.5525	4	1	4
42	R:R:W297	8.5	7	1	8
43	R:R:Y305	7.748	5	1	4
44	R:R:F324	7.36	6	4	9
45	R:R:H363	8.298	5	3	8
46	R:R:F367	6.706	5	3	7
47	R:R:C403	4.32	4	0	9
48	R:R:F404	4.6025	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W33	100	7.71	Yes	Yes	1	0	3
2	R:R:Q221	R:R:W33	98.129	15.33	Yes	Yes	1	4	3
3	R:R:Q221	R:R:R40	50.4238	8.18	Yes	No	0	4	2
4	R:R:R40	R:R:V36	49.6234	6.54	No	No	0	2	2
5	R:R:V36	R:R:W214	98.1442	7.36	No	Yes	0	2	1
6	R:R:W214	R:R:W39	93.7167	12.18	Yes	Yes	0	1	5
7	R:R:W39	R:R:Y88	72.0415	16.4	Yes	No	0	5	5
8	R:R:L89	R:R:Y88	24.9595	9.38	Yes	No	2	5	5
9	R:R:L217	R:R:Q221	49.5221	7.99	No	Yes	0	4	4
10	R:R:L217	R:R:V36	49.2553	5.96	No	No	0	4	2
11	R:R:R43	R:R:W39	20.4526	16.99	No	Yes	0	4	5
12	R:R:F66	R:R:R43	19.5204	6.41	No	No	0	7	4
13	R:R:P86	R:R:Y88	46.2952	5.56	Yes	No	2	8	5
14	R:R:C46	R:R:F66	14.7771	6.98	No	No	0	8	7
15	R:R:C46	R:R:L50	12.7744	3.17	No	No	7	8	4
16	R:R:L50	R:R:R64	11.8068	4.86	No	No	0	4	4
17	R:R:D53	R:R:R64	10.8139	11.91	No	No	0	3	4
18	R:R:P86	R:R:Y69	21.6903	13.91	Yes	Yes	2	8	6
19	R:R:R121	R:R:Y69	38.487	6.17	Yes	Yes	2	6	6
20	R:R:R102	R:R:R121	23.2438	12.79	Yes	Yes	2	8	6
21	R:R:R102	R:R:W110	17.6765	9	Yes	Yes	2	8	9
22	R:R:C62	R:R:W110	13.948	15.67	No	Yes	2	9	9
23	R:R:C104	R:R:C62	12.0466	3.64	No	No	0	9	9
24	R:R:C104	R:R:G108	10.1199	1.96	No	No	0	9	9
25	R:R:L89	R:R:Y69	20.5353	4.69	Yes	Yes	2	5	6
26	R:R:R121	R:R:W72	11.5029	4	Yes	Yes	2	6	9
27	R:R:C85	R:R:P86	22.2509	3.77	No	Yes	2	9	8
28	R:R:C85	R:R:G98	18.2354	1.96	No	No	2	9	4
29	R:R:E125	R:R:G98	17.337	3.27	No	No	0	5	4
30	R:R:E125	R:R:Y101	16.3441	11.22	No	Yes	0	5	5
31	R:R:D122	R:R:Y101	12.3387	2.3	No	Yes	0	7	5
32	R:R:D122	R:R:W120	10.3158	5.58	No	No	0	7	5
33	L:L:?1	R:R:F230	97.8318	10.31	Yes	Yes	1	0	5
34	R:R:F230	R:R:W284	89.6808	5.01	Yes	Yes	1	5	8
35	R:R:I309	R:R:W284	94.8143	17.62	No	Yes	0	7	8
36	R:R:I309	R:R:V281	94.4056	6.14	No	No	0	7	6
37	R:R:F280	R:R:V281	94.1962	3.93	Yes	No	0	5	6
38	R:R:F280	R:R:Y242	92.202	7.22	Yes	Yes	5	5	6
39	R:R:V276	R:R:Y242	92.1597	6.31	No	Yes	0	3	6
40	R:R:P277	R:R:V276	91.1668	3.53	No	No	0	9	3
41	R:R:P277	R:R:Y235	90.9102	4.17	No	No	0	9	9
42	R:R:W274	R:R:Y235	89.0189	6.75	Yes	No	0	9	9
43	R:R:W243	R:R:W274	83.8821	26.24	Yes	Yes	11	9	9
44	R:R:V246	R:R:W243	70.2449	7.36	No	Yes	0	8	9
45	R:R:V246	R:R:Y269	69.7889	5.05	No	Yes	0	8	7
46	R:R:I179	R:R:Y269	59.4343	3.63	No	Yes	0	8	7
47	R:R:E247	R:R:I179	58.9041	6.83	No	No	0	9	8
48	R:R:E247	R:R:H180	42.2611	9.85	No	Yes	0	9	9
49	R:R:H180	R:R:N177	31.1364	5.1	Yes	Yes	6	9	9
50	R:R:L172	R:R:N177	29.8582	4.12	Yes	Yes	0	9	9
51	R:R:F169	R:R:L172	28.742	6.09	Yes	Yes	0	7	9
52	R:R:F169	R:R:F413	23.8349	12.86	Yes	No	0	7	5
53	R:R:F413	R:R:I165	20.9355	7.54	No	No	0	5	8
54	R:R:C403	R:R:I165	20.2026	4.91	Yes	No	0	9	8
55	R:R:C403	R:R:L166	11.9537	3.17	Yes	No	0	9	8
56	R:R:L166	R:R:L181	11.1803	8.3	No	No	0	8	6
57	R:R:H180	R:R:Y402	11.4725	7.62	Yes	No	0	9	8
58	R:R:E247	R:R:L359	17.8538	9.28	No	No	0	9	9
59	R:R:L359	R:R:Y402	10.6231	21.1	No	No	0	9	8
60	R:R:S186	R:R:W243	28.2388	7.41	No	Yes	0	9	9
61	R:R:N240	R:R:S186	27.5363	7.45	No	No	0	9	9
62	R:R:F187	R:R:N240	14.6538	20.54	Yes	No	0	8	9
63	R:R:F187	R:R:Q394	11.6396	11.71	Yes	No	3	8	9
64	R:R:N240	R:R:R190	12.3539	10.85	No	Yes	0	9	8
65	R:R:R190	R:R:Y241	10.1604	12.35	Yes	Yes	0	8	8
66	R:R:T355	R:R:Y402	18.9514	3.75	No	No	0	8	8
67	R:R:K351	R:R:T355	13.205	6.01	No	No	0	8	8
68	R:R:K351	R:R:R348	11.7511	12.38	No	No	0	8	8
69	R:R:H363	R:R:Q394	11.0115	11.13	Yes	No	3	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:W33	7.71	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:E34	4.49	1	Yes	No	0	4	0	1
L:L:?1	R:R:P137	11.12	1	Yes	No	0	3	0	1
L:L:?1	R:R:E138	10.47	1	Yes	Yes	0	2	0	1
L:L:?1	R:R:L141	7.81	1	Yes	No	0	5	0	1
L:L:?1	R:R:L144	5.47	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y145	11.9	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y148	8.6	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:K197	16.71	1	Yes	No	0	6	0	1
L:L:?1	R:R:D198	5.36	1	Yes	No	0	7	0	1
L:L:?1	R:R:L201	7.81	1	Yes	No	0	7	0	1
L:L:?1	R:R:K202	6.36	1	Yes	No	0	4	0	1
L:L:?1	R:R:Y205	6.61	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:Y220	5.95	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:C226	4.48	1	Yes	No	0	9	0	1
L:L:?1	R:R:V229	4.2	1	Yes	No	0	7	0	1
L:L:?1	R:R:F230	10.31	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M233	4.79	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:T298	9.98	1	Yes	No	0	5	0	1
R:R:E34	R:R:V30	4.28	0	No	No	4	2	1	2
R:R:E34	R:R:S31	7.19	0	No	No	4	4	1	2
R:R:P137	R:R:S31	3.56	0	No	No	3	4	1	2
R:R:L32	R:R:Y205	14.07	0	No	Yes	4	3	2	1
R:R:Q37	R:R:W33	4.38	1	Yes	Yes	4	3	2	1
R:R:Q221	R:R:W33	15.33	1	Yes	Yes	4	3	2	1
R:R:T298	R:R:W33	8.49	1	No	Yes	5	3	1	1
R:R:Q221	R:R:Q37	7.68	1	Yes	Yes	4	4	2	2
R:R:P137	R:R:S136	3.56	0	No	No	3	1	1	2
R:R:E138	R:R:S136	10.06	1	Yes	No	2	1	1	2
R:R:E138	R:R:E139	3.81	1	Yes	No	2	2	1	2
R:R:E138	R:R:Y205	8.98	1	Yes	Yes	2	3	1	1
R:R:L141	R:R:Q140	11.98	0	No	No	5	4	1	2
R:R:F385	R:R:L141	3.65	0	No	No	6	5	2	1
R:R:L144	R:R:Y148	4.69	1	No	Yes	6	7	1	1
R:R:F385	R:R:L144	12.18	0	No	No	6	6	2	1
R:R:Y145	R:R:Y148	3.97	1	Yes	Yes	5	7	1	1
R:R:T149	R:R:Y145	8.74	0	No	Yes	7	5	2	1
R:R:D198	R:R:Y145	10.34	1	No	Yes	7	5	1	1
R:R:Y148	R:R:Y152	3.97	1	Yes	Yes	7	7	1	2
R:R:M233	R:R:S193	7.67	1	Yes	No	6	6	1	2
R:R:K197	R:R:M233	4.32	1	No	Yes	6	6	1	1
R:R:L201	R:R:Y205	4.69	1	No	Yes	7	3	1	1
R:R:M204	R:R:Y220	3.59	0	No	Yes	3	3	2	1
R:R:S223	R:R:Y220	3.82	0	No	Yes	4	3	2	1
R:R:C226	R:R:Y220	14.79	1	No	Yes	9	3	1	1
R:R:C226	R:R:C296	5.46	1	No	No	9	9	1	2
R:R:M233	R:R:V229	4.56	1	Yes	No	6	7	1	1
R:R:F230	R:R:Q234	9.37	1	Yes	No	5	7	1	2
R:R:F230	R:R:W284	5.01	1	Yes	Yes	5	8	1	2
R:R:F230	R:R:W297	4.01	1	Yes	Yes	5	8	1	2
R:R:Q234	R:R:W284	6.57	1	No	Yes	7	8	2	2
R:R:W284	R:R:W297	4.69	1	Yes	Yes	8	8	2	2
L:L:?1	R:R:A200	2.67	1	Yes	No	0	4	0	1
R:R:S225	R:R:Y220	2.54	0	No	Yes	3	3	2	1
R:R:K202	R:R:S206	1.53	0	No	No	4	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:C347	W:W:?1	22.38	0	No	No	7	0	1	0
R:R:L354	W:W:?1	2.44	0	No	No	8	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7E14_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.53
Number of Linked Nodes	349
Number of Links	394
Number of Hubs	48
Number of Links mediated by Hubs	196
Number of Communities	11
Number of Nodes involved in Communities	88
Number of Links involved in Communities	118

Path Summary
Number Of Nodes in MetaPath	70
Number Of Links MetaPath	69
Number of Shortest Paths	97814
Length Of Smallest Path	3
Average Path Length	21.5609
Length of Longest Path	51
Minimum Path Strength	1.395
Average Path Strength	8.01686
Maximum Path Strength	18.75
Minimum Path Correlation	0.7
Average Path Correlation	0.950013
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.63158
Average % Of Corr. Nodes	48.9314
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.6588
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • glucagon receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • amide binding • peptide hormone binding • hormone binding • glucagon-like peptide 1 receptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • heart process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • regulation of blood pressure • positive regulation of blood pressure • response to stress • response to psychosocial stress • cell surface receptor signaling pathway • behavior • learning or memory • cognition • transport • secretion • regulation of hormone levels • export from cell • hormone secretion • establishment of localization • localization • secretion by cell • signal release • hormone transport • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • establishment of protein localization • cellular localization • nitrogen compound transport • protein targeting • protein transmembrane transport • establishment of localization in cell • post-translational protein targeting to membrane, translocation • intracellular protein localization • establishment of protein localization to endoplasmic reticulum • establishment of protein localization to membrane • intracellular protein transmembrane transport • intracellular transport • post-translational protein targeting to endoplasmic reticulum membrane • localization within membrane • protein targeting to membrane • transmembrane transport • establishment of protein localization to organelle • protein transport • macromolecule localization • intracellular protein transport • protein targeting to ER • negative regulation of blood pressure
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • FnI-like domain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • FnI-like domain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	V6G
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	V6G
Name	Orforglipron
Synonyms	1,2,4-Oxadiazol-5(2H)-one, 3-[(1S,2S)-1-[2-[[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2,3-dihydro-2-oxo-1H-imidazol-1-yl]-2,4,6,7-tetrahydro-4-methyl-5H-pyrazolo[4,3-c]pyridin-5-yl]carbonyl]-5-[(4S)-tetrahydro-2,2-dim Orforglipron 3-[(1S,2S)-1-({2-(4-fluoro-3,5-dimethylphenyl)-3-({3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl}carbonyl)-5-[(4S)-2,2-dimethyloxan-4-yl]-1H-indol-1-yl}-2-methylcyc
Identifier
Formula	C48 H48 F2 N10 O5
Molecular Weight	882.956
SMILES
PubChem	137319706
Formal Charge	0
Total Atoms	113
Total Chiral Atoms	4
Total Bonds	123
Total Aromatic Bonds	31


Code	HNO
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	HNO
Name	N-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine
Synonyms
Identifier
Formula	C12 H13 Cl2 N3
Molecular Weight	270.158
SMILES
PubChem	156022738
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	0
Total Bonds	31
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43220
Sequence	>7E14_nogp_Chain_R T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S S P E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F R H L H C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S T A A Q Q H Q W D G L L S Y Q D S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S V L S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E D E G C W T R N S N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A D I K C R L A K S T L T L I P L L G T H E V I F A G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E V Q L E F R K S W E R W R L E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	7E14	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738	Gs/β1/γ2	2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7E14 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738		2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7DUQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738	Gs/β1/γ2	2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DUQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738		2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DUR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7DUR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	5VEW	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.7	2017-05-24	doi.org/10.1038/nature22378
	6LN2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.2	2020-03-18	doi.org/10.1038/s41467-020-14934-5
	6KJV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.1	2019-11-13	doi.org/10.1107/S2052252519013496
	5VEX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	NNC0640	-	3	2017-05-17	doi.org/10.1038/nature22378
	9IVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839	chim(NtGi1-Gs)/β2/γ2	3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	9IVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839		3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	6VCB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440	Gs/β1/γ2	3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	6VCB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440		3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	9IVG	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	chim(NtGi1-Gs)/β1/γ2	3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	9IVG (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-		3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	7RTB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-	Gs/β1/γ2	2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7RTB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-		2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7KI0	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI0 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	6X18	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X18 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	7LCI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCJ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	2.82	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCK	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	3.24	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7S15	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 134611223	-	-	3.8	2022-06-08	doi.org/10.1021/acs.jmedchem.1c01856
	9J1P	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-	chim(NtGi1-Gs)/β1/γ2	2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	9J1P (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-		2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	5VAI	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-	Gs/β1/γ2	4.1	2017-05-24	doi.org/10.1038/nature22394
	5VAI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-		4.1	2017-05-24	doi.org/10.1038/nature22394
	5NX2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	-	3.7	2017-06-14	doi.org/10.1038/nature22800
	6B3J	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-	Gs/β1/γ2	3.3	2018-02-21	doi.org/10.1038/nature25773
	6B3J (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-		3.3	2018-02-21	doi.org/10.1038/nature25773
	8WG7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WG7 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	7C2E	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-	Gs/β1/γ2	4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	7C2E (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-		4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	7LLL	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLL (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-	Gs/β1/γ2	3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-		3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7FIM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-	Gs/β1/γ2	3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-		3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBH	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7VBH (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-		3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7S1M	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-	Gs/β1/γ2	2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S1M (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-		2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	6XOX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-	chim(NtGi1-Gs)/β1/γ2	3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	6XOX (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-		3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	7RG9	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RG9 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7X8R	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-	Gs/β1/γ2	2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8R (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-		2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-	Gs/β1/γ2	3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-		3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	8JIP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-	chim(NtGi1-Gs)/β1/γ2	2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-		2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-	chim(NtGi1-Gs)/β1/γ2	2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-		2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIS	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-	chim(NtGi1-Gs)/β1/γ2	2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8JIS (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-		2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8YW3	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	9EBN	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBN (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-	Gs/β1/γ2	3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-		3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	8YWF	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ2	2.74	2025-04-16	To be published
	8YWF (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.74	2025-04-16	To be published
	9BYO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-	Gs/β1/γ2	2.31	2025-06-11	To be published
	9BYO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-		2.31	2025-06-11	To be published
	9C0K	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	2.72	2025-06-11	To be published
	9C0K (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		2.72	2025-06-11	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7E14_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.