Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:H1 2.58400
2L:L:E3 3.59400
3L:L:F6 3.752500
4L:L:I23 3.88510
5R:R:L32 8.165424
6R:R:E34 4.7625404
7R:R:W39 5.365425
8R:R:F61 7.9325473
9R:R:R64 10.138504
10R:R:Y69 4.4325416
11R:R:W72 11.312519
12R:R:C85 4.1075409
13R:R:Y88 6.24515
14R:R:L89 5.46415
15R:R:V100 3.2825417
16R:R:R102 16.004518
17R:R:W110 9.815419
18R:R:P119 10.9975416
19R:R:W120 10.078505
20R:R:L123 4.28415
21R:R:E125 7.415415
22R:R:Y148 4.002567
23R:R:Y152 3.92567
24R:R:H171 5.6325437
25R:R:N177 4.4975409
26R:R:I179 3.0425488
27R:R:R190 6.66667658
28R:R:Y205 4.6425403
29R:R:F230 3.586545
30R:R:M233 3.656546
31R:R:Y235 6.7454119
32R:R:Y241 4.8025458
33R:R:W243 9.3425409
34R:R:E247 5.935489
35R:R:F266 5.4725406
36R:R:Y269 3.4454127
37R:R:F280 5.6175405
38R:R:W284 5.3085108
39R:R:T298 4.7225405
40R:R:W306 5.596506
41R:R:F324 4.35254149
42R:R:R348 4.06754168
43R:R:T353 2.7245159
44R:R:L360 5.51254149
45R:R:E408 6.192539
46R:R:E412 6.092538
47R:R:K415 5.425437
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:E3 L:L:H1 18.86122.46YesYes000
2L:L:E3 R:R:R190 80.83385.82YesYes008
3L:L:E3 R:R:Y148 25.0193.37YesYes007
4L:L:F6 R:R:Y148 12.57374.13YesYes007
5L:L:E3 R:R:M233 99.08362.71YesYes006
6L:L:T7 R:R:M233 49.61153.01NoYes406
7L:L:T7 R:R:T298 49.74953.14NoYes005
8R:R:F230 R:R:M233 51.44973.73YesYes456
9R:R:F230 R:R:T298 51.08272.59YesYes055
10R:R:L217 R:R:V36 12.14312.98NoNo242
11R:R:V36 R:R:W39 12.85522.45NoYes225
12R:R:R43 R:R:W39 17.94768NoYes245
13R:R:E68 R:R:R43 18.51626.98NoNo244
14L:L:L26 R:R:E68 22.18162.65NoNo004
15L:L:I23 L:L:L26 22.87852.85YesNo000
16L:L:I23 R:R:Y88 53.16654.84YesYes105
17R:R:K38 R:R:Y88 94.09342.39NoYes045
18R:R:E34 R:R:K38 94.53095.4YesNo044
19R:R:E34 R:R:S31 98.75798.62YesNo044
20R:R:R299 R:R:S31 99.17472.64NoNo044
21R:R:R299 R:R:T298 1005.17NoYes045
22L:L:I23 R:R:Y69 33.97972.42YesYes106
23R:R:P86 R:R:Y88 39.77315.56NoYes185
24R:R:D67 R:R:Y69 29.87953.45NoYes096
25R:R:D67 R:R:W72 29.2538.93NoYes099
26R:R:R102 R:R:W72 50.43435.99YesYes189
27R:R:R102 R:R:W120 34.50138YesYes085
28R:R:F103 R:R:W120 27.903322.05NoYes045
29R:R:F103 R:R:F80 26.53432.14NoNo044
30R:R:F80 R:R:S79 25.16255.28NoNo045
31R:R:E76 R:R:S79 23.7882.87NoNo015
32R:R:E76 R:R:P77 22.410712.58NoNo014
33R:R:F61 R:R:P77 21.030610.11YesNo034
34R:R:C85 R:R:P86 39.24323.77YesNo098
35R:R:C85 R:R:V100 30.35983.42YesYes097
36R:R:V100 R:R:W72 27.89782.45YesYes179
37R:R:R102 R:R:W110 12.65516YesYes189
38R:R:N240 R:R:R190 67.52187.23NoYes098
39R:R:F187 R:R:N240 33.23869.67NoNo089
40R:R:F187 R:R:L159 27.88123.65NoNo089
41R:R:F184 R:R:L159 21.63376.09NoNo089
42R:R:F184 R:R:L166 20.2152.44NoNo088
43R:R:L166 R:R:N177 16.624.12NoYes089
44R:R:L172 R:R:N177 14.42982.75NoYes099
45R:R:N240 R:R:S186 42.05025.96NoNo099
46R:R:S186 R:R:W243 41.4432.47NoYes099
47R:R:W243 R:R:W274 39.622719.68YesNo099
48R:R:V270 R:R:W274 39.0322.45NoNo059
49R:R:F266 R:R:V270 38.45932.62YesNo065
50R:R:F266 R:R:I179 36.15192.51YesYes068
51R:R:V246 R:R:Y269 12.50192.52NoYes087
52R:R:R190 R:R:Y241 21.38947.2YesYes588
53R:R:I313 R:R:Y241 19.32357.25NoYes078
54R:R:A238 R:R:I313 18.78531.62NoNo067
55R:R:A238 R:R:F280 18.25124.16NoYes065
56R:R:F280 R:R:Y242 10.52294.13YesNo056
57R:R:E247 R:R:I179 30.13215.47YesYes898
58L:L:H1 R:R:W306 22.24512.12YesYes006
59R:R:I309 R:R:W306 17.27693.52NoYes076
60R:R:I309 R:R:W284 15.57395.87NoYes1078
61R:R:K288 R:R:W284 12.20936.96NoYes088
62R:R:E247 R:R:L359 28.12826.63YesNo099
63R:R:L359 R:R:Y402 27.45485.86NoNo098
64R:R:L401 R:R:Y402 26.77722.34NoNo088
65R:R:L401 R:R:P358 25.38193.28NoNo089
66R:R:I357 R:R:P358 23.97843.39NoNo089
67R:R:F324 R:R:I357 14.57753.77YesNo098
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:H1 R:R:V237 4.15 0 Yes No 0 6 0 1
L:L:G2 R:R:L388 3.42 0 No No 0 7 0 1
L:L:E3 R:R:Y148 3.37 0 Yes Yes 0 7 0 1
L:L:E3 R:R:R190 5.82 0 Yes Yes 0 8 0 1
L:L:E3 R:R:M233 2.71 0 Yes Yes 0 6 0 1
L:L:F6 R:R:L144 2.44 0 Yes No 0 6 0 1
L:L:F6 R:R:Y148 4.13 0 Yes Yes 0 7 0 1
L:L:F6 R:R:L384 2.44 0 Yes No 0 5 0 1
L:L:T7 R:R:K197 4.5 4 No No 0 6 0 1
L:L:T7 R:R:M233 3.01 4 No Yes 0 6 0 1
L:L:T7 R:R:T298 3.14 4 No Yes 0 5 0 1
L:L:S11 R:R:T298 7.99 0 No Yes 0 5 0 1
L:L:M14 R:R:Y205 3.59 0 No Yes 0 3 0 1
L:L:E15 R:R:L32 5.3 0 No Yes 0 4 0 1
L:L:E15 R:R:Y205 6.73 0 No Yes 0 3 0 1
L:L:F22 R:R:W39 5.01 0 No Yes 0 5 0 1
L:L:F22 R:R:W214 3.01 0 No No 0 1 0 1
L:L:I23 R:R:Y69 2.42 1 Yes Yes 0 6 0 1
L:L:I23 R:R:Y88 4.84 1 Yes Yes 0 5 0 1
L:L:I23 R:R:L89 4.28 1 Yes Yes 0 5 0 1
L:L:W25 R:R:W214 12.18 0 No No 0 1 0 1
L:L:L26 R:R:E68 2.65 0 No No 0 4 0 1
L:L:K27 R:R:Y69 7.17 1 No Yes 0 6 0 1
L:L:K27 R:R:L123 2.82 1 No Yes 0 5 0 1
R:R:L32 R:R:T35 4.42 2 Yes No 4 5 1 2
R:R:L217 R:R:L32 8.3 2 No Yes 4 4 2 1
R:R:L32 R:R:Q221 14.64 2 Yes No 4 4 1 2
R:R:V36 R:R:W39 2.45 2 No Yes 2 5 2 1
R:R:R40 R:R:V36 6.54 2 No No 2 2 2 2
R:R:L217 R:R:V36 2.98 2 No No 4 2 2 2
R:R:K38 R:R:Y88 2.39 0 No Yes 4 5 2 1
R:R:R40 R:R:W39 6 2 No Yes 2 5 2 1
R:R:R43 R:R:W39 8 2 No Yes 4 5 2 1
R:R:P86 R:R:Y42 6.95 1 No No 8 6 2 2
R:R:Y42 R:R:Y88 14.89 1 No Yes 6 5 2 1
R:R:F66 R:R:R43 24.59 2 No No 7 4 2 2
R:R:E68 R:R:R43 6.98 2 No No 4 4 1 2
R:R:E68 R:R:F66 11.66 2 No No 4 7 1 2
R:R:D67 R:R:Y69 3.45 0 No Yes 9 6 2 1
R:R:L123 R:R:Y69 4.69 1 Yes Yes 5 6 1 1
R:R:P86 R:R:Y88 5.56 1 No Yes 8 5 2 1
R:R:L89 R:R:Y88 3.52 1 Yes Yes 5 5 1 1
R:R:L89 R:R:P90 4.93 1 Yes No 5 4 1 2
R:R:L89 R:R:W91 9.11 1 Yes No 5 4 1 2
R:R:L123 R:R:V100 2.98 1 Yes Yes 5 7 1 2
R:R:E125 R:R:V100 4.28 1 Yes Yes 5 7 2 2
R:R:E125 R:R:L123 6.63 1 Yes Yes 5 5 2 1
R:R:T149 R:R:Y148 2.5 0 No Yes 7 7 2 1
R:R:Y148 R:R:Y152 4.96 6 Yes Yes 7 7 1 2
R:R:V194 R:R:Y148 5.05 6 No Yes 7 7 2 1
R:R:V194 R:R:Y152 2.52 6 No Yes 7 7 2 2
R:R:C236 R:R:R190 2.79 0 No Yes 5 8 2 1
R:R:R190 R:R:V237 13.08 5 Yes No 8 6 1 1
R:R:N240 R:R:R190 7.23 0 No Yes 9 8 2 1
R:R:R190 R:R:Y241 7.2 5 Yes Yes 8 8 1 2
R:R:R190 R:R:T391 3.88 5 Yes No 8 6 1 2
R:R:M233 R:R:S193 3.07 4 Yes No 6 6 1 2
R:R:C236 R:R:S193 6.89 0 No No 5 6 2 2
R:R:F230 R:R:K197 6.2 4 Yes No 5 6 2 1
R:R:K197 R:R:M233 5.76 4 No Yes 6 6 1 1
R:R:L201 R:R:Y205 5.86 0 No Yes 7 3 2 1
R:R:M204 R:R:Y205 2.39 0 No Yes 3 3 2 1
R:R:M204 R:R:Q221 4.08 0 No No 3 4 2 2
R:R:L217 R:R:Q221 5.32 2 No No 4 4 2 2
R:R:F230 R:R:M233 3.73 4 Yes Yes 5 6 2 1
R:R:F230 R:R:T298 2.59 4 Yes Yes 5 5 2 1
R:R:V237 R:R:Y241 2.52 5 No Yes 6 8 1 2
R:R:R299 R:R:T298 5.17 0 No Yes 4 5 2 1
R:R:N300 R:R:W306 4.52 0 No Yes 6 6 1 1
R:R:M303 R:R:W306 5.82 0 No Yes 5 6 2 1
R:R:I309 R:R:W306 3.52 10 No Yes 7 6 2 1
R:R:R310 R:R:W306 12 0 No Yes 6 6 2 1
R:R:K383 R:R:L384 4.23 0 No No 7 5 2 1
R:R:E387 R:R:K383 9.45 0 No No 8 7 2 2
R:R:L384 R:R:L388 11.07 0 No No 5 7 1 1
R:R:E387 R:R:L388 5.3 0 No No 8 7 2 1
L:L:H1 R:R:W306 2.12 0 Yes Yes 0 6 0 1
L:L:S8 R:R:N300 1.49 0 No No 0 6 0 1
L:L:F6 R:R:L141 1.22 0 Yes No 0 5 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7LLL_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.34
Number of Linked Nodes 348
Number of Links 376
Number of Hubs 47
Number of Links mediated by Hubs 172
Number of Communities 17
Number of Nodes involved in Communities 75
Number of Links involved in Communities 88
Path Summary
Number Of Nodes in MetaPath 68
Number Of Links MetaPath 67
Number of Shortest Paths 107072
Length Of Smallest Path 3
Average Path Length 21.1375
Length of Longest Path 47
Minimum Path Strength 1.25
Average Path Strength 5.50318
Maximum Path Strength 24.48
Minimum Path Correlation 0.7
Average Path Correlation 0.961125
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.33333
Average % Of Corr. Nodes 55.7437
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.7617
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • molecular transducer activity   • molecular function activator activity   • signaling receptor binding   • signaling receptor activity   • signaling receptor activator activity   • hormone activity   • molecular function regulator activity   • signaling receptor regulator activity   • receptor ligand activity   • toxin activity   • circulatory system process   • regulation of blood pressure   • regulation of biological quality   • blood circulation   • glucagon receptor activity   • peptide receptor activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • transmembrane signaling receptor activity   • amide binding   • peptide hormone binding   • hormone binding   • glucagon-like peptide 1 receptor activity   • positive regulation of cytosolic calcium ion concentration   • heart process   • regulation of heart contraction   • regulation of system process   • regulation of blood circulation   • regulation of multicellular organismal process   • heart contraction   • positive regulation of blood pressure   • response to stress   • response to psychosocial stress   • cell surface receptor signaling pathway   • behavior   • learning or memory   • cognition   • transport   • secretion   • regulation of hormone levels   • export from cell   • hormone secretion   • establishment of localization   • localization   • secretion by cell   • signal release   • hormone transport   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • protein localization   • establishment of protein localization   • cellular localization   • nitrogen compound transport   • protein targeting   • protein transmembrane transport   • cellular macromolecule localization   • establishment of localization in cell   • post-translational protein targeting to membrane, translocation   • establishment of protein localization to endoplasmic reticulum   • protein localization to endoplasmic reticulum   • establishment of protein localization to membrane   • intracellular protein transmembrane transport   • intracellular transport   • post-translational protein targeting to endoplasmic reticulum membrane   • localization within membrane   • protein localization to membrane   • protein targeting to membrane   • transmembrane transport   • establishment of protein localization to organelle   • protein transport   • macromolecule localization   • protein localization to organelle   • intracellular protein transport   • protein targeting to ER   • negative regulation of blood pressure
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • FnI-like domain   • G protein-coupled receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • FnI-like domain   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP43220
Sequence
>7LLL_nogp_Chain_R
TVSLWETVQ KWREYRRQC QRSLTEDPP PATDLFCNR TFDEYACWP 
DGEPGSFVN VSCPWYLPW ASSVPQGHV YRFCTAEGL WLQKDNSSL 
PWRDLSECE EQLLFLYII YTVGYALSF SALVIASAI LLGFRHLHC 
TRNYIHLNL FASFILRAL SVFIKDAAL KWMYSWDGL LSYQDSLSC 
RLVFLLMQY CVAANYYWL LVEGVYLYT LLAFSVFSE QWIFRLYVS 
IGWGVPLLF VVPWGIVKY LYEDEGCWT RNSNMNYWL IIRLPILFA 
IGVNFLIFV RVICIVVSK LKANDIKCR LAKSTLTLI PLLGTHEVI 
FAFVMDGTL RFIKLFTEL SFTSFQGLM VAILYCFVN NEVQLEFRK 
SWERWR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9IVMB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN3318839chim(NtGi1-Gs)/β2/γ23.222024-11-1310.1016/j.apsb.2024.09.002
9IVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN33188393.222024-11-1310.1016/j.apsb.2024.09.002
8YW3B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-Gs/β1/γ22.682024-09-18doi.org/10.1038/s41421-024-00700-0
8YW3 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-2.682024-09-18doi.org/10.1038/s41421-024-00700-0
8WG7B1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.542024-03-0610.1038/s41421-024-00649-0
8WG7 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.542024-03-0610.1038/s41421-024-00649-0
8JISB1PeptideGlucagonGLP-1Homo sapiensPeptide-15-chim(NtGi1-Gs)/β1/γ22.462023-11-0810.1073/pnas.2303696120
8JIS (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-15-2.462023-11-0810.1073/pnas.2303696120
8JIRB1PeptideGlucagonGLP-1Homo sapiensSAR425899-chim(NtGi1-Gs)/β1/γ22.572023-09-0610.1073/pnas.2303696120
8JIR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSAR425899-2.572023-09-0610.1073/pnas.2303696120
8JIPB1PeptideGlucagonGLP-1Homo sapiensMEDI0382-chim(NtGi1-Gs)/β1/γ22.852023-09-0610.1073/pnas.2303696120
8JIP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensMEDI0382-2.852023-09-0610.1073/pnas.2303696120
9IVGB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ232024-11-2710.1016/j.apsb.2024.09.002
9IVG (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-32024-11-2710.1016/j.apsb.2024.09.002
9J1PB1PeptideGlucagonGLP-1Homo sapiensg1:Ox-chim(NtGi1-Gs)/β1/γ22.992025-02-2610.1021/jacs.4c12808
9J1P (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensg1:Ox-2.992025-02-2610.1021/jacs.4c12808
7X8SB1PeptideGlucagonGLP-1Homo sapiensWB4-24-Gs/β1/γ23.092022-06-2910.1073/pnas.2200155119
7X8S (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensWB4-24-3.092022-06-2910.1073/pnas.2200155119
7X8RB1PeptideGlucagonGLP-1Homo sapiensBOC5-Gs/β1/γ22.612022-06-2910.1073/pnas.2200155119
7X8R (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensBOC5-2.612022-06-2910.1073/pnas.2200155119
7S15B1PeptideGlucagonGLP-1Homo sapiensPubChem 134611223--3.82022-06-0810.1021/acs.jmedchem.1c01856
7RGPB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-chim(NtGi1-Gs)/β1/γ22.92022-04-1310.1073/pnas.2116506119
7RGP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-2.92022-04-1310.1073/pnas.2116506119
7RG9B1PeptideGlucagonGLP-1Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22022-04-1310.1073/pnas.2116506119
7RG9 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.22022-04-1310.1073/pnas.2116506119
7VBHB1PeptideGlucagonGLP-1Homo sapiensPeptide-20-Gs/β1/γ232022-04-0610.1038/s41467-022-28683-0
7VBH (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-20-32022-04-0610.1038/s41467-022-28683-0
7VBIB1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-Gs/β1/γ232022-03-0210.1038/s41467-022-28683-0
7VBI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-32022-03-0210.1038/s41467-022-28683-0
7FIMB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-Gs/β1/γ23.42022-03-0210.1038/s41467-022-28683-0
7FIM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-3.42022-03-0210.1038/s41467-022-28683-0
7LLYB1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-Gs/β1/γ23.32022-01-1210.1038/s41467-021-27760-0
7LLY (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-3.32022-01-1210.1038/s41467-021-27760-0
7LLLB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/β1/γ23.72022-01-1210.1038/s41467-021-27760-0
7LLL (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-4-3.72022-01-1210.1038/s41467-021-27760-0
7S3IB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.512022-01-0510.1038/s41589-021-00945-w
7S3I (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.512022-01-0510.1038/s41589-021-00945-w
7S1MB1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-Gs/β1/γ22.412022-01-0510.1038/s41589-021-00945-w
7S1M (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-2.412022-01-0510.1038/s41589-021-00945-w
7RTBB1PeptideGlucagonGLP-1Homo sapiensPeptide-19-Gs/β1/γ22.142021-10-0610.1016/j.bbrc.2021.09.016
7RTB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-19-2.142021-10-0610.1016/j.bbrc.2021.09.016
7EVMB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ22.52021-08-1110.1038/s41467-021-24058-z
7EVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227382.52021-08-1110.1038/s41467-021-24058-z
7DURB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ23.32021-08-1110.1038/s41467-021-24058-z
7DUR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227383.32021-08-1110.1038/s41467-021-24058-z
7KI1B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-Gs/β1/γ22.52021-08-0410.1016/j.celrep.2021.109374
7KI1 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-2.52021-08-0410.1016/j.celrep.2021.109374
7KI0B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-Gs/β1/γ22.52021-08-0410.1016/j.celrep.2021.109374
7KI0 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-2.52021-08-0410.1016/j.celrep.2021.109374
7DUQB1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 156022738Gs/β1/γ22.52021-07-1410.1038/s41467-021-24058-z
7DUQ (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 1560227382.52021-07-1410.1038/s41467-021-24058-z
7E14B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 156022738Gs/β1/γ22.92021-07-0710.1038/s41467-021-24058-z
7E14 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 1560227382.92021-07-0710.1038/s41467-021-24058-z
7LCKB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--3.242021-01-2010.1016/j.str.2021.04.008
7LCJB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--2.822021-01-2010.1016/j.str.2021.04.008
7LCIB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.92021-01-2010.1016/j.str.2021.04.008
7LCI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.92021-01-2010.1016/j.str.2021.04.008
6XOXB1PeptideGlucagonGLP-1Homo sapiensOrforglipron-chim(NtGi1-Gs)/β1/γ23.12020-11-1810.1073/pnas.2014879117
6XOX (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipron-3.12020-11-1810.1073/pnas.2014879117
6X1AB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.52020-09-0910.1016/j.molcel.2020.09.020
6X1A (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.52020-09-0910.1016/j.molcel.2020.09.020
6X19B1PeptideGlucagonGLP-1Homo sapiensCHU-128-Gs/β1/γ22.12020-09-0910.1016/j.molcel.2020.09.020
6X19 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensCHU-128-2.12020-09-0910.1016/j.molcel.2020.09.020
6X18B1PeptideGlucagonGLP-1Homo sapiensGLP-1-Gs/β1/γ22.12020-09-0910.1016/j.molcel.2020.09.020
6X18 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1-2.12020-09-0910.1016/j.molcel.2020.09.020
7C2EB1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-Gs/β1/γ24.22020-08-2610.1038/s41422-020-0384-8
7C2E (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-4.22020-08-2610.1038/s41422-020-0384-8
6VCBB1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN3160440Gs/β1/γ23.32020-07-2210.1038/s41589-020-0589-7
6VCB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN31604403.32020-07-2210.1038/s41589-020-0589-7
6LN2B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-3.22020-03-1810.1038/s41467-020-14934-5
6ORVB1PeptideGlucagonGLP-1Homo sapiens-TT-OAD2Gs/β1/γ232020-01-0810.1038/s41586-019-1902-z
6ORV (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-TT-OAD232020-01-0810.1038/s41586-019-1902-z
6KK7B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-3.12019-11-1310.1107/S2052252519013496
6KK1B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-2.82019-11-1310.1107/S2052252519013496
6KJVB1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-2.82019-11-1310.1107/S2052252519013496
6B3JB1PeptideGlucagonGLP-1Homo sapiensExendin-P5-Gs/β1/γ23.32018-02-2110.1038/nature25773
6B3J (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-P5-3.32018-02-2110.1038/nature25773
5NX2B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)--3.72017-06-1410.1038/nature22800
5VEWB1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.72017-05-2410.1038/nature22378
5VAIB1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-Gs/β1/γ24.12017-05-2410.1038/nature22394
5VAI (No Gprot) B1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-4.12017-05-2410.1038/nature22394
5VEXB1PeptideGlucagonGLP-1Homo sapiens-NNC0640-32017-05-1710.1038/nature22378




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Download 7LLL_nogp.zip



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