psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:H1	R:R:Q234	8.65	Yes	Yes	2	0	7
2	L:L:H1	R:R:V237	17.99	Yes	No	0	0	6
3	L:L:H1	R:R:W306	9.52	Yes	Yes	2	0	6
4	L:L:H1	R:R:I313	5.3	Yes	No	0	0	7
5	L:L:A2	R:R:E387	6.03	No	Yes	0	0	8
6	L:L:E3	R:R:Y152	8.98	Yes	Yes	7	0	7
7	L:L:E3	R:R:R190	10.47	Yes	Yes	7	0	8
8	L:L:E3	R:R:V194	4.28	Yes	No	7	0	7
9	L:L:E3	R:R:L388	5.3	Yes	No	0	0	7
10	L:L:G4	L:L:T7	3.64	No	No	0	0	0
11	L:L:D9	L:L:T5	4.34	No	Yes	2	0	0
12	L:L:T5	R:R:D372	14.45	Yes	Yes	2	0	5
13	L:L:T5	R:R:R380	3.88	Yes	Yes	2	0	5
14	L:L:T5	R:R:L384	5.9	Yes	No	0	0	5
15	L:L:F6	L:L:V10	5.24	Yes	No	5	0	0
16	L:L:F6	R:R:L141	4.87	Yes	No	5	0	5
17	L:L:F6	R:R:L144	7.31	Yes	No	0	0	6
18	L:L:F6	R:R:Y148	8.25	Yes	Yes	5	0	7
19	L:L:F6	R:R:L388	6.09	Yes	No	0	0	7
20	L:L:T7	R:R:K197	12.01	No	Yes	0	0	6
21	L:L:S8	R:R:N300	7.45	No	No	0	0	6
22	L:L:D9	R:R:R380	11.91	No	Yes	2	0	5
23	L:L:V10	R:R:L141	5.96	No	No	5	0	5
24	L:L:S11	R:R:Y205	5.09	No	Yes	3	0	3
25	L:L:S11	R:R:T298	6.4	No	Yes	3	0	5
26	L:L:S11	R:R:R299	9.22	No	Yes	3	0	4
27	L:L:L14	L:L:Y13	3.52	No	Yes	0	0	0
28	L:L:Q17	L:L:Y13	11.27	No	Yes	0	0	0
29	L:L:Y13	R:R:E138	12.35	Yes	No	0	0	2
30	L:L:L14	R:R:Y205	11.72	No	Yes	0	0	3
31	L:L:E15	R:R:S31	4.31	Yes	No	0	0	4
32	L:L:E15	R:R:Y205	15.71	Yes	Yes	3	0	3
33	L:L:E15	R:R:Q221	5.1	Yes	Yes	3	0	4
34	L:L:E15	R:R:R299	13.96	Yes	Yes	3	0	4
35	L:L:K20	L:L:Q17	5.42	No	No	11	0	0
36	L:L:N45	L:L:Q17	3.96	No	No	11	0	0
37	L:L:A18	R:R:Q210	4.55	No	No	0	0	4
38	L:L:A19	R:R:P90	3.74	No	Yes	0	0	4
39	L:L:K20	L:L:N45	9.79	No	No	11	0	0
40	L:L:C21	L:L:C47	7.28	No	No	0	0	0
41	L:L:F22	L:L:I23	3.77	Yes	No	4	0	0
42	L:L:F22	L:L:L26	6.09	Yes	No	4	0	0
43	L:L:F22	R:R:L32	3.65	Yes	Yes	4	0	4
44	L:L:F22	R:R:V36	6.55	Yes	No	0	0	2
45	L:L:F22	R:R:W39	5.01	Yes	Yes	4	0	5
46	L:L:F22	R:R:W214	12.03	Yes	No	4	0	1
47	L:L:I23	R:R:P90	5.08	No	Yes	4	0	4
48	L:L:I23	R:R:W91	4.7	No	Yes	4	0	4
49	L:L:W25	R:R:W214	15.93	No	No	0	0	1
50	L:L:L26	R:R:W39	11.39	No	Yes	4	0	5
51	L:L:L26	R:R:Y88	4.69	No	Yes	4	0	5
52	L:L:I27	R:R:Y69	6.04	No	Yes	0	0	6
53	L:L:C29	L:L:C43	7.28	No	No	0	0	0
54	L:L:E32	R:R:L118	3.98	No	Yes	1	0	4
55	L:L:E32	R:R:R121	11.63	No	Yes	1	0	6
56	L:L:E32	R:R:L123	5.3	No	No	1	0	5
57	L:L:C33	L:L:C39	7.28	No	No	8	0	0
58	L:L:P35	L:L:V34	3.53	Yes	No	0	0	0
59	L:L:P35	L:L:S37	3.56	Yes	No	12	0	0
60	L:L:P35	R:R:K113	6.69	Yes	No	12	0	4
61	L:L:P35	R:R:D114	8.05	Yes	No	0	0	4
62	L:L:S37	R:R:K113	9.18	No	No	12	0	4
63	L:L:C43	L:L:P40	5.65	No	Yes	0	0	0
64	L:L:P40	R:R:E127	7.86	Yes	No	0	0	2
65	L:L:D41	R:R:E127	7.8	No	No	0	0	2
66	L:L:D41	R:R:E128	6.5	No	No	0	0	3
67	L:L:V42	R:R:W91	3.68	No	Yes	0	0	4
68	L:L:P48	R:R:T207	6.99	Yes	No	0	0	3
69	R:R:E34	R:R:V30	5.7	No	No	0	4	2
70	R:R:L32	R:R:Q213	9.32	Yes	No	0	4	4
71	R:R:L32	R:R:W214	4.56	Yes	No	4	4	1
72	R:R:Q37	R:R:W33	17.52	No	No	0	4	3
73	R:R:E34	R:R:K38	5.4	No	No	0	4	4
74	R:R:P90	R:R:T35	3.5	Yes	No	0	4	5
75	R:R:R40	R:R:V36	3.92	Yes	No	0	2	2
76	R:R:Q37	R:R:R40	3.5	No	Yes	0	4	2
77	R:R:R40	R:R:W39	4	Yes	Yes	0	2	5
78	R:R:R43	R:R:W39	12	No	Yes	0	4	5
79	R:R:W39	R:R:Y88	19.29	Yes	Yes	4	5	5
80	R:R:E41	R:R:R44	9.3	No	No	0	4	3
81	R:R:E41	R:R:Q45	11.47	No	No	13	4	5
82	R:R:E41	R:R:W87	7.63	No	Yes	13	4	3
83	R:R:F66	R:R:Y42	4.13	No	Yes	0	7	6
84	R:R:C71	R:R:Y42	6.72	No	Yes	0	9	6
85	R:R:P86	R:R:Y42	4.17	No	Yes	0	8	6
86	R:R:W87	R:R:Y42	14.47	Yes	Yes	0	3	6
87	R:R:Y42	R:R:Y88	8.94	Yes	Yes	0	6	5
88	R:R:F66	R:R:R43	5.34	No	No	0	7	4
89	R:R:Q45	R:R:W87	7.67	No	Yes	13	5	3
90	R:R:C46	R:R:F66	11.17	No	No	0	8	7
91	R:R:C46	R:R:C71	7.28	No	No	0	8	9
92	R:R:R48	R:R:S49	5.27	No	No	0	4	2
93	R:R:E52	R:R:R48	12.79	No	No	0	2	4
94	R:R:L50	R:R:R64	3.64	No	Yes	0	4	4
95	R:R:D53	R:R:R64	14.29	No	Yes	0	3	4
96	R:R:P56	R:R:R64	8.65	No	Yes	1	1	4
97	R:R:D74	R:R:P56	11.27	Yes	No	1	3	1
98	R:R:F61	R:R:T58	6.49	No	No	0	3	1
99	R:R:D59	R:R:L60	5.43	No	No	0	3	1
100	R:R:D74	R:R:F61	3.58	Yes	No	0	3	3
101	R:R:F61	R:R:P77	10.11	No	No	0	3	4
102	R:R:C62	R:R:D74	6.22	Yes	Yes	1	9	3
103	R:R:C62	R:R:G75	3.92	Yes	No	0	9	7
104	R:R:C62	R:R:P77	3.77	Yes	No	0	9	4
105	R:R:C104	R:R:C62	5.46	No	Yes	1	9	9
106	R:R:C62	R:R:G108	3.92	Yes	No	1	9	9
107	R:R:C62	R:R:W110	3.92	Yes	Yes	1	9	9
108	R:R:D74	R:R:R64	3.57	Yes	Yes	1	3	4
109	R:R:R102	R:R:T65	3.88	Yes	No	0	8	5
110	R:R:D67	R:R:W72	8.93	No	Yes	1	9	9
111	R:R:D67	R:R:R121	10.72	No	Yes	1	9	6
112	R:R:P86	R:R:Y69	5.56	No	Yes	0	8	6
113	R:R:N82	R:R:W72	14.69	No	Yes	1	4	9
114	R:R:V83	R:R:W72	6.13	No	Yes	0	5	9
115	R:R:V100	R:R:W72	8.58	No	Yes	0	7	9
116	R:R:R102	R:R:W72	21.99	Yes	Yes	1	8	9
117	R:R:R121	R:R:W72	5	Yes	Yes	1	6	9
118	R:R:P73	R:R:V83	3.53	No	No	0	5	5
119	R:R:E76	R:R:P77	4.72	No	No	0	1	4
120	R:R:F80	R:R:Y101	10.32	No	Yes	0	4	5
121	R:R:F103	R:R:F80	5.36	No	No	0	4	4
122	R:R:N82	R:R:Y101	4.65	No	Yes	0	4	5
123	R:R:N82	R:R:R102	3.62	No	Yes	1	4	8
124	R:R:H99	R:R:S84	8.37	No	No	0	4	4
125	R:R:C126	R:R:C85	7.28	No	No	0	9	9
126	R:R:L89	R:R:Y88	3.52	No	Yes	0	5	5
127	R:R:L89	R:R:W91	11.39	No	Yes	0	5	4
128	R:R:P90	R:R:W91	10.81	Yes	Yes	4	4	4
129	R:R:E128	R:R:W91	13.08	No	Yes	0	3	4
130	R:R:G98	R:R:V95	3.68	No	No	0	4	5
131	R:R:H99	R:R:Y101	10.89	No	Yes	0	4	5
132	R:R:E125	R:R:Y101	5.61	No	Yes	0	5	5
133	R:R:R102	R:R:W110	26.99	Yes	Yes	1	8	9
134	R:R:P119	R:R:R102	8.65	No	Yes	0	6	8
135	R:R:F103	R:R:L111	3.65	No	No	0	4	4
136	R:R:C104	R:R:G108	3.92	No	No	1	9	9
137	R:R:C104	R:R:W110	7.84	No	Yes	1	9	9
138	R:R:E107	R:R:T105	9.88	No	No	1	5	4
139	R:R:G108	R:R:T105	3.64	No	No	1	9	4
140	R:R:L109	R:R:T105	5.9	No	No	1	5	4
141	R:R:E107	R:R:L109	9.28	No	No	1	5	5
142	R:R:Q112	R:R:S116	8.66	No	No	0	3	5
143	R:R:K113	R:R:W120	12.76	No	No	0	4	5
144	R:R:D114	R:R:N115	4.04	No	No	0	4	4
145	R:R:L118	R:R:P119	4.93	Yes	No	0	4	6
146	R:R:L118	R:R:R121	3.64	Yes	Yes	1	4	6
147	R:R:L123	R:R:R121	8.5	No	Yes	1	5	6
148	R:R:D122	R:R:S124	8.83	No	No	0	7	5
149	R:R:D122	R:R:E125	16.89	No	No	0	7	5
150	R:R:E138	R:R:S135	5.75	No	No	0	2	1
151	R:R:P137	R:R:S136	3.56	No	No	0	3	1
152	R:R:F381	R:R:Q140	9.37	No	No	0	4	4
153	R:R:F143	R:R:I147	10.05	No	No	0	4	6
154	R:R:F381	R:R:L144	4.87	No	No	0	4	6
155	R:R:F385	R:R:L144	3.65	No	No	0	6	6
156	R:R:Y145	R:R:Y148	4.96	Yes	Yes	5	5	7
157	R:R:T149	R:R:Y145	7.49	No	Yes	0	7	5
158	R:R:D198	R:R:Y145	9.2	No	Yes	5	7	5
159	R:R:K202	R:R:Y145	3.58	No	Yes	0	4	5
160	R:R:F385	R:R:I147	3.77	No	No	0	6	6
161	R:R:K197	R:R:Y148	4.78	Yes	Yes	5	6	7
162	R:R:D198	R:R:Y148	9.2	No	Yes	5	7	7
163	R:R:S392	R:R:Y148	3.82	No	Yes	0	9	7
164	R:R:G151	R:R:V150	3.68	No	No	0	8	5
165	R:R:F393	R:R:G151	9.03	No	No	0	7	8
166	R:R:R190	R:R:Y152	10.29	Yes	Yes	7	8	7
167	R:R:A191	R:R:Y152	4	No	Yes	0	7	7
168	R:R:V194	R:R:Y152	11.36	No	Yes	7	7	7
169	R:R:S392	R:R:Y152	8.9	No	Yes	0	9	7
170	R:R:G395	R:R:S155	3.71	No	No	0	9	9
171	R:R:F156	R:R:V160	3.93	No	No	0	7	3
172	R:R:F156	R:R:I188	5.02	No	No	0	7	7
173	R:R:F156	R:R:L192	8.53	No	No	0	7	3
174	R:R:F184	R:R:L159	6.09	Yes	Yes	0	8	9
175	R:R:F187	R:R:L159	6.09	Yes	Yes	0	8	9
176	R:R:F404	R:R:I161	3.77	No	No	0	8	4
177	R:R:A162	R:R:F184	4.16	No	Yes	0	9	8
178	R:R:A162	R:R:C403	3.61	No	No	0	9	9
179	R:R:F184	R:R:S163	3.96	Yes	No	0	8	6
180	R:R:F413	R:R:I165	6.28	No	No	0	5	8
181	R:R:L166	R:R:N177	4.12	No	No	0	8	9
182	R:R:L166	R:R:L181	8.3	No	No	0	8	6
183	R:R:F184	R:R:L166	3.65	Yes	No	0	8	8
184	R:R:L167	R:R:L181	4.15	No	No	0	3	6
185	R:R:F169	R:R:L172	4.87	Yes	No	14	7	9
186	R:R:E412	R:R:F169	8.16	Yes	Yes	14	8	7
187	R:R:F169	R:R:F413	10.72	Yes	No	0	7	5
188	R:R:H173	R:R:R170	4.51	No	No	0	7	8
189	R:R:E412	R:R:H171	14.77	Yes	No	0	8	7
190	R:R:E408	R:R:L172	3.98	No	No	0	9	9
191	R:R:E412	R:R:L172	3.98	Yes	No	14	8	9
192	R:R:H173	R:R:Y178	10.89	No	No	0	7	6
193	R:R:C174	R:R:R176	4.18	No	No	0	8	9
194	R:R:C174	R:R:N177	4.72	No	No	0	8	9
195	R:R:T175	R:R:Y250	4.99	No	Yes	0	7	8
196	R:R:E262	R:R:T175	5.64	No	No	0	6	7
197	R:R:F266	R:R:T175	3.89	No	No	0	6	7
198	R:R:H180	R:R:R176	5.64	No	No	0	9	9
199	R:R:F266	R:R:Y178	7.22	No	No	0	6	6
200	R:R:E247	R:R:I179	5.47	Yes	No	0	9	8
201	R:R:I179	R:R:Y250	7.25	No	Yes	0	8	8
202	R:R:E247	R:R:H180	12.31	Yes	No	0	9	9
203	R:R:H180	R:R:Y402	6.53	No	Yes	0	9	8
204	R:R:N182	R:R:W243	16.95	No	Yes	9	9	9
205	R:R:N182	R:R:W274	5.65	No	Yes	9	9	9
206	R:R:F187	R:R:L183	6.09	Yes	No	0	8	9
207	R:R:E247	R:R:L183	7.95	Yes	No	0	9	9
208	R:R:F184	R:R:V398	3.93	Yes	No	0	8	9
209	R:R:N240	R:R:S186	5.96	No	No	0	9	9
210	R:R:S186	R:R:W243	6.18	No	Yes	9	9	9
211	R:R:S186	R:R:W274	4.94	No	Yes	9	9	9
212	R:R:F187	R:R:N240	15.71	Yes	No	0	8	9
213	R:R:F187	R:R:Q394	7.03	Yes	No	0	8	9
214	R:R:F187	R:R:G395	9.03	Yes	No	0	8	9
215	R:R:F187	R:R:V398	3.93	Yes	No	0	8	9
216	R:R:R190	R:R:V237	6.54	Yes	No	0	8	6
217	R:R:N240	R:R:R190	10.85	No	Yes	0	9	8
218	R:R:R190	R:R:Y241	8.23	Yes	Yes	0	8	8
219	R:R:R190	R:R:T391	5.17	Yes	No	0	8	6
220	R:R:M233	R:R:S193	4.6	No	No	0	6	6
221	R:R:C236	R:R:S193	6.89	No	No	0	5	6
222	R:R:I196	R:R:V229	4.61	No	No	0	5	7
223	R:R:D198	R:R:K197	6.91	No	Yes	5	7	6
224	R:R:F230	R:R:K197	4.96	Yes	Yes	0	5	6
225	R:R:K197	R:R:M233	4.32	Yes	No	0	6	6
226	R:R:A199	R:R:W203	3.89	No	No	0	3	3
227	R:R:F230	R:R:L201	3.65	Yes	No	0	5	7
228	R:R:W203	R:R:Y220	5.79	No	Yes	0	3	3
229	R:R:M204	R:R:Y205	7.18	Yes	Yes	3	3	3
230	R:R:M204	R:R:Q221	10.88	Yes	Yes	3	3	4
231	R:R:C296	R:R:M204	8.1	No	Yes	0	9	3
232	R:R:M204	R:R:T298	4.52	Yes	Yes	3	3	5
233	R:R:Q221	R:R:Y205	6.76	Yes	Yes	3	4	3
234	R:R:R299	R:R:Y205	4.12	Yes	Yes	3	4	3
235	R:R:H212	R:R:L217	7.71	No	No	0	3	4
236	R:R:Q213	R:R:S219	10.11	No	No	0	4	5
237	R:R:Q213	R:R:Q221	5.12	No	Yes	0	4	4
238	R:R:D222	R:R:L218	4.07	No	No	0	6	3
239	R:R:S223	R:R:Y220	5.09	No	Yes	0	4	3
240	R:R:S225	R:R:Y220	3.82	No	Yes	0	3	3
241	R:R:C226	R:R:Y220	5.38	No	Yes	0	9	3
242	R:R:L224	R:R:L228	4.15	No	No	0	3	4
243	R:R:C226	R:R:C296	7.28	No	No	0	9	9
244	R:R:D293	R:R:R227	10.72	No	No	15	7	8
245	R:R:R227	R:R:W297	21.99	No	Yes	15	8	8
246	R:R:F230	R:R:T298	10.38	Yes	Yes	0	5	5
247	R:R:M233	R:R:Q234	4.08	No	Yes	0	6	7
248	R:R:Q234	R:R:W284	10.95	Yes	Yes	2	7	8
249	R:R:Q234	R:R:W306	6.57	Yes	Yes	2	7	6
250	R:R:I309	R:R:Q234	6.86	Yes	Yes	2	7	7
251	R:R:W274	R:R:Y235	4.82	Yes	No	0	9	9
252	R:R:P277	R:R:Y235	5.56	No	No	0	9	9
253	R:R:L278	R:R:Y235	7.03	No	No	0	3	9
254	R:R:I313	R:R:Y241	16.92	No	Yes	0	7	8
255	R:R:I317	R:R:Y241	4.84	No	Yes	0	7	8
256	R:R:E364	R:R:Y241	12.35	Yes	Yes	0	8	8
257	R:R:V276	R:R:Y242	7.57	No	Yes	0	3	6
258	R:R:F280	R:R:Y242	7.22	No	Yes	16	5	6
259	R:R:P312	R:R:Y242	4.17	No	Yes	16	8	6
260	R:R:A316	R:R:Y242	4	No	Yes	0	7	6
261	R:R:V246	R:R:W243	7.36	No	Yes	0	8	9
262	R:R:G273	R:R:W243	8.44	No	Yes	0	9	9
263	R:R:W243	R:R:W274	24.37	Yes	Yes	9	9	9
264	R:R:L244	R:R:Q394	5.32	No	No	0	9	9
265	R:R:V246	R:R:Y269	3.79	No	Yes	0	8	7
266	R:R:E247	R:R:L359	5.3	Yes	No	0	9	9
267	R:R:G248	R:R:I323	3.53	No	No	0	8	8
268	R:R:V249	R:R:Y269	3.79	No	Yes	0	6	7
269	R:R:L254	R:R:Y250	15.24	No	Yes	0	8	8
270	R:R:Y250	R:R:Y269	8.94	Yes	Yes	0	8	7
271	R:R:L251	R:R:L255	4.15	No	No	6	9	8
272	R:R:L251	R:R:V327	4.47	No	Yes	6	9	9
273	R:R:A256	R:R:Y252	6.67	No	No	0	6	8
274	R:R:F257	R:R:T253	3.89	No	No	0	5	7
275	R:R:T253	R:R:Y269	4.99	No	Yes	0	7	7
276	R:R:L255	R:R:V327	4.47	No	Yes	6	8	9
277	R:R:I330	R:R:L255	4.28	No	No	0	9	8
278	R:R:Q263	R:R:R267	8.18	No	No	0	5	4
279	R:R:I265	R:R:Y269	8.46	No	Yes	0	5	7
280	R:R:F266	R:R:V270	5.24	No	No	0	6	5
281	R:R:G273	R:R:I272	3.53	No	No	0	9	6
282	R:R:P277	R:R:V276	3.53	No	No	0	9	3
283	R:R:F280	R:R:P312	18.78	No	No	16	5	8
284	R:R:P283	R:R:V282	3.53	No	No	0	5	3
285	R:R:G285	R:R:W284	4.22	No	Yes	0	5	8
286	R:R:K288	R:R:W284	12.76	No	Yes	0	8	8
287	R:R:I309	R:R:W284	11.74	Yes	Yes	2	7	8
288	R:R:V287	R:R:Y305	8.83	No	Yes	0	4	4
289	R:R:E292	R:R:K288	8.1	Yes	No	0	6	8
290	R:R:K288	R:R:W297	15.08	No	Yes	0	8	8
291	R:R:Y291	R:R:Y305	7.94	No	Yes	0	3	4
292	R:R:E292	R:R:E294	7.61	Yes	No	3	6	4
293	R:R:E292	R:R:S301	8.62	Yes	No	3	6	3
294	R:R:E292	R:R:N302	3.94	Yes	No	3	6	5
295	R:R:E292	R:R:Y305	7.86	Yes	Yes	3	6	4
296	R:R:D293	R:R:W297	4.47	No	Yes	15	7	8
297	R:R:E294	R:R:R299	9.3	No	Yes	3	4	4
298	R:R:E294	R:R:S301	7.19	No	No	3	4	3
299	R:R:R299	R:R:T298	5.17	Yes	Yes	3	4	5
300	R:R:N300	R:R:W306	19.21	No	Yes	0	6	6
301	R:R:N302	R:R:N304	6.81	No	No	0	5	3
302	R:R:N302	R:R:Y305	15.12	No	Yes	3	5	4
303	R:R:D372	R:R:M303	4.16	Yes	No	0	5	5
304	R:R:E373	R:R:M303	8.12	Yes	No	0	4	5
305	R:R:I309	R:R:W306	7.05	Yes	Yes	2	7	6
306	R:R:R310	R:R:W306	20.99	Yes	Yes	2	6	6
307	R:R:D372	R:R:W306	4.47	Yes	Yes	2	5	6
308	R:R:L307	R:R:R310	8.5	No	Yes	0	7	6
309	R:R:M371	R:R:R310	6.2	No	Yes	2	7	6
310	R:R:D372	R:R:R310	3.57	Yes	Yes	2	5	6
311	R:R:E373	R:R:R310	10.47	Yes	Yes	2	4	6
312	R:R:F315	R:R:V319	6.55	No	No	0	4	6
313	R:R:L360	R:R:N320	5.49	Yes	No	0	9	9
314	R:R:F321	R:R:V325	3.93	No	No	0	6	5
315	R:R:F321	R:R:V365	9.18	No	No	0	6	6
316	R:R:F324	R:R:I328	8.79	Yes	No	0	9	7
317	R:R:F324	R:R:L356	7.31	Yes	No	6	9	9
318	R:R:F324	R:R:L360	3.65	Yes	Yes	6	9	9
319	R:R:F324	R:R:T362	6.49	Yes	No	0	9	7
320	R:R:I330	R:R:R326	7.52	No	No	0	9	8
321	R:R:I328	R:R:T353	4.56	No	No	0	7	9
322	R:R:L335	R:R:R348	6.07	No	No	0	8	8
323	R:R:K351	R:R:R348	7.43	No	No	0	8	8
324	R:R:L356	R:R:L360	6.92	No	Yes	6	9	9
325	R:R:I357	R:R:T362	6.08	No	No	0	8	7
326	R:R:L359	R:R:L360	4.15	No	Yes	0	9	9
327	R:R:L359	R:R:Y402	15.24	No	Yes	0	9	8
328	R:R:E364	R:R:H363	8.62	Yes	No	0	8	8
329	R:R:F390	R:R:H363	9.05	No	No	0	6	8
330	R:R:H363	R:R:Q394	8.65	No	No	0	8	9
331	R:R:E364	R:R:E387	13.95	Yes	Yes	0	8	8
332	R:R:E364	R:R:T391	4.23	Yes	No	0	8	6
333	R:R:F367	R:R:I366	3.77	Yes	No	0	7	6
334	R:R:F367	R:R:I382	3.77	Yes	No	0	7	4
335	R:R:F367	R:R:K383	4.96	Yes	No	10	7	7
336	R:R:F367	R:R:T386	7.78	Yes	No	0	7	4
337	R:R:E387	R:R:F367	3.5	Yes	Yes	10	8	7
338	R:R:E373	R:R:M371	4.06	Yes	No	2	4	7
339	R:R:D372	R:R:R380	9.53	Yes	Yes	2	5	5
340	R:R:E373	R:R:H374	3.69	Yes	No	0	4	3
341	R:R:A375	R:R:R380	4.15	No	Yes	0	4	5
342	R:R:R376	R:R:R380	5.33	No	Yes	0	5	5
343	R:R:E387	R:R:K383	8.1	Yes	No	10	8	7
344	R:R:F385	R:R:S389	7.93	No	No	0	6	5
345	R:R:F390	R:R:S389	3.96	No	No	0	6	5
346	R:R:I400	R:R:L396	5.71	No	No	0	6	7
347	R:R:F404	R:R:I400	3.77	No	No	0	8	6
348	R:R:E408	R:R:N406	5.26	No	No	0	9	9
349	R:R:N406	R:R:V409	5.91	No	No	0	9	9
350	R:R:E412	R:R:K415	8.1	Yes	No	0	8	7
351	R:R:K415	R:R:R419	4.95	No	No	0	7	7
352	R:R:W417	R:R:W420	3.75	No	No	0	5	4
353	R:R:R421	R:R:W417	13.99	No	No	0	4	5
354	R:R:E418	R:R:R421	8.14	No	No	0	4	4
355	R:R:E408	R:R:R176	3.49	No	No	0	9	9
356	R:R:K38	R:R:W87	3.48	No	Yes	0	4	3
357	R:R:D67	R:R:Y69	3.45	No	Yes	0	9	6
358	R:R:L111	R:R:W120	3.42	No	No	0	4	5
359	R:R:L231	R:R:W297	3.42	No	Yes	0	5	8
360	L:L:A24	L:L:V42	3.39	No	No	0	0	0
361	R:R:N63	R:R:W110	3.39	No	Yes	0	4	9
362	R:R:A200	R:R:V229	3.39	No	No	0	4	7
363	R:R:I357	R:R:P358	3.39	No	No	0	8	9
364	R:R:C341	R:R:I345	3.27	No	No	0	4	5
365	R:R:A368	R:R:I317	3.25	No	No	0	6	7
366	R:R:S352	R:R:V331	3.23	No	No	0	9	8
367	L:L:S12	R:R:T29	3.2	No	No	0	0	2
368	R:R:C236	R:R:L232	3.17	No	No	0	5	5
369	R:R:P96	R:R:Q97	3.16	No	No	0	3	4
370	R:R:A399	R:R:L159	3.15	No	Yes	0	8	9
371	R:R:A316	R:R:L245	3.15	No	No	0	7	8
372	L:L:A38	R:R:D122	3.09	No	No	0	0	7
373	R:R:R326	R:R:Y252	3.09	No	No	0	8	8
374	R:R:I309	R:R:V281	3.07	Yes	No	0	7	6
375	R:R:I317	R:R:V365	3.07	No	No	0	7	6
376	R:R:F103	R:R:G78	3.01	No	No	0	4	7
377	R:R:L396	R:R:S155	3	No	No	0	7	9
378	R:R:K351	R:R:T355	3	No	No	0	8	8
379	R:R:L245	R:R:V319	2.98	No	No	0	8	6
380	R:R:L356	R:R:V327	2.98	No	Yes	6	9	9
381	R:R:L349	R:R:V332	2.98	No	No	0	9	6
382	R:R:L349	R:R:T353	2.95	No	No	0	9	9
383	L:L:N45	L:L:T44	2.92	No	No	0	0	0
384	R:R:I330	R:R:K334	2.91	No	No	0	9	9
385	R:R:Q263	R:R:S261	2.89	No	No	0	5	7
386	R:R:W297	R:R:Y289	2.89	Yes	No	0	8	3
387	R:R:D344	R:R:T343	2.89	No	No	0	7	5
388	R:R:E76	R:R:S79	2.87	No	No	0	1	5
389	R:R:I188	R:R:L159	2.85	No	Yes	0	7	9
390	R:R:I286	R:R:L290	2.85	No	No	0	4	3
391	R:R:L314	R:R:M371	2.83	No	No	0	4	7
392	R:R:L401	R:R:M397	2.83	No	No	0	8	5
393	R:R:E52	R:R:T51	2.82	No	No	0	2	4
394	R:R:M340	R:R:N338	2.8	No	No	0	5	6
395	L:L:Y13	R:R:P137	2.78	Yes	No	0	0	3
396	R:R:A200	R:R:F230	2.77	No	Yes	0	4	5
397	R:R:A238	R:R:F280	2.77	No	No	0	6	5
398	R:R:L307	R:R:L311	2.77	No	No	0	7	4
399	R:R:A70	R:R:Y69	2.67	No	Yes	0	5	6
400	L:L:S12	R:R:R299	2.64	No	Yes	0	0	4
401	R:R:F169	R:R:S416	2.64	Yes	No	0	7	5
402	R:R:D215	R:R:Q211	2.61	No	No	0	3	4
403	R:R:A239	R:R:W274	2.59	No	Yes	0	8	9
404	R:R:T355	R:R:Y402	2.5	No	Yes	0	8	8
405	R:R:S94	R:R:W91	2.47	No	Yes	0	4	4
406	R:R:S261	R:R:W264	2.47	No	No	0	7	5
407	R:R:I323	R:R:Y252	2.42	No	No	0	8	8
408	R:R:I265	R:R:W264	2.35	No	No	0	5	5
409	R:R:I308	R:R:W284	2.35	No	Yes	0	8	8
410	R:R:Q47	R:R:R43	2.34	No	No	0	3	4
411	R:R:L268	R:R:Y269	2.34	No	Yes	0	2	7
412	R:R:L290	R:R:Y291	2.34	No	No	0	3	3
413	R:R:L401	R:R:Y402	2.34	No	Yes	0	8	8
414	R:R:L189	R:R:W274	2.28	No	Yes	0	7	9
415	R:R:F195	R:R:Y152	2.06	No	Yes	0	7	7
416	R:R:G275	R:R:P277	2.03	No	No	0	6	9
417	L:L:C33	L:L:G36	1.96	No	No	8	0	0
418	L:L:C39	L:L:G36	1.96	No	No	8	0	0
419	R:R:C85	R:R:G98	1.96	No	No	0	9	4
420	R:R:C296	R:R:G295	1.96	No	No	0	9	4
421	R:R:P54	R:R:P55	1.95	No	No	0	2	1
422	R:R:P55	R:R:P56	1.95	No	No	0	1	1
423	L:L:C29	L:L:P30	1.88	No	No	0	0	0
424	L:L:C33	L:L:P40	1.88	No	Yes	8	0	0
425	L:L:C39	L:L:P40	1.88	No	Yes	8	0	0
426	L:L:C47	L:L:P48	1.88	No	Yes	0	0	0
427	R:R:C85	R:R:P86	1.88	No	No	0	9	8
428	R:R:G151	R:R:S392	1.86	No	No	0	8	9
429	L:L:G31	L:L:V34	1.84	No	No	0	0	0
430	R:R:A158	R:R:A399	1.79	No	No	0	7	8
431	R:R:P96	R:R:V95	1.77	No	No	0	3	5
432	R:R:A158	R:R:S157	1.71	No	No	0	7	3
433	R:R:A208	R:R:S206	1.71	No	No	0	4	4
434	R:R:A209	R:R:S206	1.71	No	No	0	1	4
435	R:R:G361	R:R:L244	1.71	No	No	0	9	9
436	R:R:C329	R:R:V325	1.71	No	No	0	7	5
437	R:R:G361	R:R:L360	1.71	No	Yes	0	9	9
438	R:R:A375	R:R:V370	1.7	No	No	0	4	5
439	R:R:D215	R:R:G216	1.68	No	No	0	3	2
440	L:L:E15	L:L:G16	1.64	Yes	No	0	0	0
441	L:L:L49	L:L:P48	1.64	No	Yes	0	0	0
442	L:L:N28	L:L:P30	1.63	No	No	0	0	0
443	R:R:V327	R:R:V331	1.6	Yes	No	0	9	8
444	R:R:S352	R:R:T353	1.6	No	No	0	9	9
445	L:L:A18	R:R:L32	1.58	No	Yes	0	0	4
446	L:L:P48	R:R:Q210	1.58	Yes	No	0	0	4
447	R:R:A57	R:R:D74	1.54	No	Yes	0	1	3
448	R:R:I286	R:R:V282	1.54	No	No	0	4	3
449	R:R:I400	R:R:V405	1.54	No	No	0	6	6
450	R:R:K336	R:R:V332	1.52	No	No	0	6	6
451	R:R:I382	R:R:T378	1.52	No	No	0	4	2
452	R:R:A106	R:R:E107	1.51	No	No	0	1	5
453	R:R:F321	R:R:G318	1.51	No	No	0	6	4
454	R:R:G216	R:R:R40	1.5	No	Yes	0	2	2
455	R:R:L118	R:R:S116	1.5	Yes	No	0	4	5
456	R:R:L260	R:R:S258	1.5	No	No	0	7	7
457	R:R:K342	R:R:T343	1.5	No	No	0	5	5
458	R:R:G377	R:R:R376	1.5	No	No	0	4	5
459	R:R:L379	R:R:V370	1.49	No	No	0	3	5
460	R:R:L50	R:R:T51	1.47	No	No	0	4	4
461	R:R:D222	R:R:S219	1.47	No	No	0	6	5
462	R:R:I146	R:R:L142	1.43	No	No	0	4	3
463	R:R:I345	R:R:L335	1.43	No	No	0	5	8
464	R:R:K415	R:R:L411	1.41	No	No	0	7	4
465	R:R:A153	R:R:F195	1.39	No	No	0	6	7
466	R:R:A368	R:R:F369	1.39	No	No	0	6	4
467	R:R:L228	R:R:L231	1.38	No	No	0	4	5
468	R:R:D215	R:R:L217	1.36	No	No	0	3	4
469	R:R:N407	R:R:Q410	1.32	No	No	0	6	7
470	R:R:F393	R:R:L154	1.22	No	No	0	7	5
471	R:R:I146	R:R:Y145	1.21	No	Yes	0	4	5
472	L:L:W25	R:R:E68	1.09	No	No	0	0	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:H1	10.365	4	2	0
2	L:L:E3	7.2575	4	7	0
3	L:L:T5	7.1425	4	2	0
4	L:L:F6	6.352	5	5	0
5	L:L:Y13	7.48	4	0	0
6	L:L:E15	8.144	5	3	0
7	L:L:F22	6.18333	6	4	0
8	L:L:P35	5.4575	4	12	0
9	L:L:P40	4.3175	4	8	0
10	L:L:P48	3.0225	4	0	0
11	R:R:L32	4.7775	4	4	4
12	R:R:W39	10.338	5	4	5
13	R:R:R40	3.23	4	0	2
14	R:R:Y42	7.686	5	0	6
15	R:R:C62	4.535	6	1	9
16	R:R:R64	7.5375	4	1	4
17	R:R:Y69	4.43	4	0	6
18	R:R:W72	10.8867	6	1	9
19	R:R:D74	5.236	5	1	3
20	R:R:W87	8.3125	4	13	3
21	R:R:Y88	9.11	4	4	5
22	R:R:P90	5.7825	4	4	4
23	R:R:W91	7.68833	6	4	4
24	R:R:Y101	7.8675	4	0	5
25	R:R:R102	13.026	5	1	8
26	R:R:W110	10.535	4	1	9
27	R:R:L118	3.5125	4	1	4
28	R:R:R121	7.898	5	1	6
29	R:R:Y145	5.288	5	5	5
30	R:R:Y148	6.202	5	5	7
31	R:R:Y152	7.59833	6	7	7
32	R:R:L159	4.545	4	0	9
33	R:R:F169	6.5975	4	14	7
34	R:R:F184	4.358	5	0	8
35	R:R:F187	7.98	6	0	8
36	R:R:R190	8.59167	6	7	8
37	R:R:K197	6.596	5	5	6
38	R:R:M204	7.67	4	3	3
39	R:R:Y205	8.43	6	3	3
40	R:R:Y220	5.02	4	0	3
41	R:R:Q221	6.965	4	3	4
42	R:R:F230	5.44	4	0	5
43	R:R:Q234	7.422	5	2	7
44	R:R:Y241	10.585	4	0	8
45	R:R:Y242	5.74	4	16	6
46	R:R:W243	12.66	5	9	9
47	R:R:E247	7.7575	4	0	9
48	R:R:Y250	9.105	4	0	8
49	R:R:Y269	5.385	6	0	7
50	R:R:W274	7.44167	6	9	9
51	R:R:W284	8.404	5	2	8
52	R:R:E292	7.226	5	3	6
53	R:R:W297	9.57	5	15	8
54	R:R:T298	6.6175	4	3	5
55	R:R:R299	7.40167	6	3	4
56	R:R:Y305	9.9375	4	3	4
57	R:R:W306	11.3017	6	2	6
58	R:R:I309	7.18	4	2	7
59	R:R:R310	9.946	5	2	6
60	R:R:F324	6.56	4	6	9
61	R:R:V327	3.38	4	6	9
62	R:R:L360	4.384	5	6	9
63	R:R:E364	9.7875	4	0	8
64	R:R:F367	4.756	5	10	7
65	R:R:D372	7.236	5	2	5
66	R:R:E373	6.585	4	2	4
67	R:R:R380	6.96	5	2	5
68	R:R:E387	7.895	4	10	8
69	R:R:Y402	6.6525	4	0	8
70	R:R:E412	8.7525	4	14	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E364	R:R:E387	10.577	13.95	Yes	Yes	0	8	8
2	R:R:E364	R:R:Y241	10.0774	12.35	Yes	Yes	0	8	8
3	R:R:R190	R:R:V237	11.488	6.54	Yes	No	0	8	6
4	L:L:H1	R:R:V237	11.629	17.99	Yes	No	0	0	6
5	R:R:R190	R:R:Y152	71.5627	10.29	Yes	Yes	7	8	7
6	R:R:K197	R:R:M233	18.0293	4.32	Yes	No	0	6	6
7	R:R:M233	R:R:Q234	17.7881	4.08	No	Yes	0	6	7
8	L:L:H1	R:R:Q234	15.2287	8.65	Yes	Yes	2	0	7
9	R:R:K197	R:R:Y148	78.7512	4.78	Yes	Yes	5	6	7
10	R:R:F230	R:R:K197	96.0332	4.96	Yes	Yes	0	5	6
11	R:R:F230	R:R:T298	96.0332	10.38	Yes	Yes	0	5	5
12	R:R:M204	R:R:T298	86.2541	4.52	Yes	Yes	3	3	5
13	R:R:R299	R:R:Y205	12.2428	4.12	Yes	Yes	3	4	3
14	R:R:K288	R:R:W284	10.9431	12.76	No	Yes	0	8	8
15	R:R:E292	R:R:K288	12.7176	8.1	Yes	No	0	6	8
16	R:R:E292	R:R:E294	14.7958	7.61	Yes	No	3	6	4
17	R:R:E294	R:R:R299	15.682	9.3	No	Yes	3	4	4
18	L:L:L14	R:R:Y205	13.5877	11.72	No	Yes	0	0	3
19	L:L:L14	L:L:Y13	12.2385	3.52	No	Yes	0	0	0
20	R:R:M204	R:R:Q221	81.7618	10.88	Yes	Yes	3	3	4
21	R:R:L32	R:R:Q213	99.3496	9.32	Yes	No	0	4	4
22	R:R:Q213	R:R:Q221	100	5.12	No	Yes	0	4	4
23	L:L:F22	R:R:L32	96.661	3.65	Yes	Yes	4	0	4
24	L:L:F22	L:L:L26	39.6959	6.09	Yes	No	4	0	0
25	L:L:F22	R:R:W39	45.1314	5.01	Yes	Yes	4	0	5
26	L:L:L26	R:R:Y88	39.3492	4.69	No	Yes	4	0	5
27	R:R:W39	R:R:Y88	40.4023	19.29	Yes	Yes	4	5	5
28	R:R:Y42	R:R:Y88	79.9281	8.94	Yes	Yes	0	6	5
29	R:R:P86	R:R:Y42	72.8774	4.17	No	Yes	0	8	6
30	R:R:P86	R:R:Y69	66.9552	5.56	No	Yes	0	8	6
31	R:R:D67	R:R:Y69	64.3915	3.45	No	Yes	0	9	6
32	R:R:D67	R:R:W72	57.0006	8.93	No	Yes	1	9	9
33	R:R:N82	R:R:W72	18.9069	14.69	No	Yes	1	4	9
34	R:R:N82	R:R:Y101	18.8003	4.65	No	Yes	0	4	5
35	R:R:F80	R:R:Y101	11.9639	10.32	No	Yes	0	4	5
36	R:R:F103	R:R:F80	10.9787	5.36	No	No	0	4	4
37	R:R:R102	R:R:W72	34.8559	21.99	Yes	Yes	1	8	9
38	R:R:R102	R:R:W110	33.0211	26.99	Yes	Yes	1	8	9
39	R:R:C62	R:R:W110	25.3071	3.92	Yes	Yes	1	9	9
40	R:R:C62	R:R:D74	13.7858	6.22	Yes	Yes	1	9	3
41	R:R:S392	R:R:Y152	72.2335	8.9	No	Yes	0	9	7
42	R:R:N240	R:R:R190	75.284	10.85	No	Yes	0	9	8
43	R:R:F187	R:R:N240	60.0414	15.71	Yes	No	0	8	9
44	R:R:F187	R:R:L183	35.0895	6.09	Yes	No	0	8	9
45	R:R:E247	R:R:L183	34.6728	7.95	Yes	No	0	9	9
46	R:R:E247	R:R:H180	13.6684	12.31	Yes	No	0	9	9
47	R:R:N240	R:R:S186	22.1339	5.96	No	No	0	9	9
48	R:R:S186	R:R:W243	11.5773	6.18	No	Yes	9	9	9
49	R:R:E247	R:R:L359	18.2727	5.3	Yes	No	0	9	9
50	R:R:S186	R:R:W274	10.0117	4.94	No	Yes	9	9	9
51	R:R:F187	R:R:Q394	15.0661	7.03	Yes	No	0	8	9
52	R:R:L244	R:R:Q394	15.4117	5.32	No	No	0	9	9
53	R:R:L359	R:R:L360	14.0722	4.15	No	Yes	0	9	9
54	R:R:L356	R:R:L360	14.4868	6.92	No	Yes	6	9	9
55	R:R:L356	R:R:V327	13.4434	2.98	No	Yes	6	9	9
56	R:R:G361	R:R:L244	14.8895	1.71	No	No	0	9	9
57	R:R:G361	R:R:L360	14.4222	1.71	No	Yes	0	9	9
58	R:R:F324	R:R:L360	11.1434	3.65	Yes	Yes	6	9	9
59	R:R:S392	R:R:Y148	72.9711	3.82	No	Yes	0	9	7
60	R:R:Q221	R:R:Y205	10.3789	6.76	Yes	Yes	3	4	3

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:H1	R:R:Q234	8.65	2	Yes	Yes	0	7	0	1
L:L:H1	R:R:V237	17.99	2	Yes	No	0	6	0	1
L:L:H1	R:R:W306	9.52	2	Yes	Yes	0	6	0	1
L:L:H1	R:R:I313	5.3	2	Yes	No	0	7	0	1
L:L:A2	R:R:E387	6.03	0	No	Yes	0	8	0	1
L:L:E3	R:R:Y152	8.98	7	Yes	Yes	0	7	0	1
L:L:E3	R:R:R190	10.47	7	Yes	Yes	0	8	0	1
L:L:E3	R:R:V194	4.28	7	Yes	No	0	7	0	1
L:L:E3	R:R:L388	5.3	7	Yes	No	0	7	0	1
L:L:T5	R:R:D372	14.45	2	Yes	Yes	0	5	0	1
L:L:T5	R:R:R380	3.88	2	Yes	Yes	0	5	0	1
L:L:T5	R:R:L384	5.9	2	Yes	No	0	5	0	1
L:L:F6	R:R:L141	4.87	5	Yes	No	0	5	0	1
L:L:F6	R:R:L144	7.31	5	Yes	No	0	6	0	1
L:L:F6	R:R:Y148	8.25	5	Yes	Yes	0	7	0	1
L:L:F6	R:R:L388	6.09	5	Yes	No	0	7	0	1
L:L:T7	R:R:K197	12.01	0	No	Yes	0	6	0	1
L:L:S8	R:R:N300	7.45	0	No	No	0	6	0	1
L:L:D9	R:R:R380	11.91	2	No	Yes	0	5	0	1
L:L:V10	R:R:L141	5.96	5	No	No	0	5	0	1
L:L:S11	R:R:Y205	5.09	3	No	Yes	0	3	0	1
L:L:S11	R:R:T298	6.4	3	No	Yes	0	5	0	1
L:L:S11	R:R:R299	9.22	3	No	Yes	0	4	0	1
L:L:Y13	R:R:E138	12.35	0	Yes	No	0	2	0	1
L:L:L14	R:R:Y205	11.72	0	No	Yes	0	3	0	1
L:L:E15	R:R:S31	4.31	3	Yes	No	0	4	0	1
L:L:E15	R:R:Y205	15.71	3	Yes	Yes	0	3	0	1
L:L:E15	R:R:Q221	5.1	3	Yes	Yes	0	4	0	1
L:L:E15	R:R:R299	13.96	3	Yes	Yes	0	4	0	1
L:L:A18	R:R:Q210	4.55	0	No	No	0	4	0	1
L:L:A19	R:R:P90	3.74	0	No	Yes	0	4	0	1
L:L:F22	R:R:L32	3.65	4	Yes	Yes	0	4	0	1
L:L:F22	R:R:V36	6.55	4	Yes	No	0	2	0	1
L:L:F22	R:R:W39	5.01	4	Yes	Yes	0	5	0	1
L:L:F22	R:R:W214	12.03	4	Yes	No	0	1	0	1
L:L:I23	R:R:P90	5.08	4	No	Yes	0	4	0	1
L:L:I23	R:R:W91	4.7	4	No	Yes	0	4	0	1
L:L:W25	R:R:W214	15.93	0	No	No	0	1	0	1
L:L:L26	R:R:W39	11.39	4	No	Yes	0	5	0	1
L:L:L26	R:R:Y88	4.69	4	No	Yes	0	5	0	1
L:L:I27	R:R:Y69	6.04	0	No	Yes	0	6	0	1
L:L:E32	R:R:L118	3.98	1	No	Yes	0	4	0	1
L:L:E32	R:R:R121	11.63	1	No	Yes	0	6	0	1
L:L:E32	R:R:L123	5.3	1	No	No	0	5	0	1
L:L:P35	R:R:K113	6.69	12	Yes	No	0	4	0	1
L:L:P35	R:R:D114	8.05	12	Yes	No	0	4	0	1
L:L:S37	R:R:K113	9.18	12	No	No	0	4	0	1
L:L:P40	R:R:E127	7.86	8	Yes	No	0	2	0	1
L:L:D41	R:R:E127	7.8	0	No	No	0	2	0	1
L:L:D41	R:R:E128	6.5	0	No	No	0	3	0	1
L:L:V42	R:R:W91	3.68	0	No	Yes	0	4	0	1
L:L:P48	R:R:T207	6.99	0	Yes	No	0	3	0	1
R:R:L32	R:R:Q213	9.32	4	Yes	No	4	4	1	2
R:R:L32	R:R:W214	4.56	4	Yes	No	4	1	1	1
R:R:P90	R:R:T35	3.5	4	Yes	No	4	5	1	2
R:R:R40	R:R:V36	3.92	0	Yes	No	2	2	2	1
R:R:R40	R:R:W39	4	0	Yes	Yes	2	5	2	1
R:R:R43	R:R:W39	12	0	No	Yes	4	5	2	1
R:R:W39	R:R:Y88	19.29	4	Yes	Yes	5	5	1	1
R:R:P86	R:R:Y42	4.17	0	No	Yes	8	6	2	2
R:R:Y42	R:R:Y88	8.94	0	Yes	Yes	6	5	2	1
R:R:D67	R:R:W72	8.93	1	No	Yes	9	9	2	2
R:R:D67	R:R:R121	10.72	1	No	Yes	9	6	2	1
R:R:P86	R:R:Y69	5.56	0	No	Yes	8	6	2	1
R:R:R121	R:R:W72	5	1	Yes	Yes	6	9	1	2
R:R:L89	R:R:Y88	3.52	0	No	Yes	5	5	2	1
R:R:L89	R:R:W91	11.39	0	No	Yes	5	4	2	1
R:R:P90	R:R:W91	10.81	4	Yes	Yes	4	4	1	1
R:R:E128	R:R:W91	13.08	0	No	Yes	3	4	1	1
R:R:K113	R:R:W120	12.76	12	No	No	4	5	1	2
R:R:D114	R:R:N115	4.04	0	No	No	4	4	1	2
R:R:L118	R:R:P119	4.93	1	Yes	No	4	6	1	2
R:R:L118	R:R:R121	3.64	1	Yes	Yes	4	6	1	1
R:R:L123	R:R:R121	8.5	1	No	Yes	5	6	1	1
R:R:D122	R:R:S124	8.83	0	No	No	7	5	1	2
R:R:D122	R:R:E125	16.89	0	No	No	7	5	1	2
R:R:E138	R:R:S135	5.75	0	No	No	2	1	1	2
R:R:P137	R:R:S136	3.56	0	No	No	3	1	1	2
R:R:F381	R:R:L144	4.87	0	No	No	4	6	2	1
R:R:F385	R:R:L144	3.65	0	No	No	6	6	2	1
R:R:Y145	R:R:Y148	4.96	5	Yes	Yes	5	7	2	1
R:R:D198	R:R:Y145	9.2	5	No	Yes	7	5	2	2
R:R:K197	R:R:Y148	4.78	5	Yes	Yes	6	7	1	1
R:R:D198	R:R:Y148	9.2	5	No	Yes	7	7	2	1
R:R:S392	R:R:Y148	3.82	0	No	Yes	9	7	2	1
R:R:R190	R:R:Y152	10.29	7	Yes	Yes	8	7	1	1
R:R:A191	R:R:Y152	4	0	No	Yes	7	7	2	1
R:R:V194	R:R:Y152	11.36	7	No	Yes	7	7	1	1
R:R:S392	R:R:Y152	8.9	0	No	Yes	9	7	2	1
R:R:R190	R:R:V237	6.54	7	Yes	No	8	6	1	1
R:R:N240	R:R:R190	10.85	0	No	Yes	9	8	2	1
R:R:R190	R:R:Y241	8.23	7	Yes	Yes	8	8	1	2
R:R:R190	R:R:T391	5.17	7	Yes	No	8	6	1	2
R:R:D198	R:R:K197	6.91	5	No	Yes	7	6	2	1
R:R:F230	R:R:K197	4.96	0	Yes	Yes	5	6	2	1
R:R:K197	R:R:M233	4.32	5	Yes	No	6	6	1	2
R:R:M204	R:R:Y205	7.18	3	Yes	Yes	3	3	2	1
R:R:M204	R:R:Q221	10.88	3	Yes	Yes	3	4	2	1
R:R:M204	R:R:T298	4.52	3	Yes	Yes	3	5	2	1
R:R:Q221	R:R:Y205	6.76	3	Yes	Yes	4	3	1	1
R:R:R299	R:R:Y205	4.12	3	Yes	Yes	4	3	1	1
R:R:Q213	R:R:Q221	5.12	0	No	Yes	4	4	2	1
R:R:F230	R:R:T298	10.38	0	Yes	Yes	5	5	2	1
R:R:M233	R:R:Q234	4.08	0	No	Yes	6	7	2	1
R:R:Q234	R:R:W284	10.95	2	Yes	Yes	7	8	1	2
R:R:Q234	R:R:W306	6.57	2	Yes	Yes	7	6	1	1
R:R:I309	R:R:Q234	6.86	2	Yes	Yes	7	7	2	1
R:R:I313	R:R:Y241	16.92	0	No	Yes	7	8	1	2
R:R:E364	R:R:Y241	12.35	0	Yes	Yes	8	8	2	2
R:R:I309	R:R:W284	11.74	2	Yes	Yes	7	8	2	2
R:R:E294	R:R:R299	9.3	3	No	Yes	4	4	2	1
R:R:R299	R:R:T298	5.17	3	Yes	Yes	4	5	1	1
R:R:N300	R:R:W306	19.21	0	No	Yes	6	6	1	1
R:R:D372	R:R:M303	4.16	2	Yes	No	5	5	1	2
R:R:I309	R:R:W306	7.05	2	Yes	Yes	7	6	2	1
R:R:R310	R:R:W306	20.99	2	Yes	Yes	6	6	2	1
R:R:D372	R:R:W306	4.47	2	Yes	Yes	5	6	1	1
R:R:D372	R:R:R310	3.57	2	Yes	Yes	5	6	1	2
R:R:E364	R:R:E387	13.95	0	Yes	Yes	8	8	2	1
R:R:E364	R:R:T391	4.23	0	Yes	No	8	6	2	2
R:R:F367	R:R:K383	4.96	10	Yes	No	7	7	2	2
R:R:E387	R:R:F367	3.5	10	Yes	Yes	8	7	1	2
R:R:D372	R:R:R380	9.53	2	Yes	Yes	5	5	1	1
R:R:A375	R:R:R380	4.15	0	No	Yes	4	5	2	1
R:R:R376	R:R:R380	5.33	0	No	Yes	5	5	2	1
R:R:E387	R:R:K383	8.1	10	Yes	No	8	7	1	2
R:R:D67	R:R:Y69	3.45	1	No	Yes	9	6	2	1
L:L:S12	R:R:T29	3.2	0	No	No	0	2	0	1
L:L:A38	R:R:D122	3.09	0	No	No	0	7	0	1
L:L:Y13	R:R:P137	2.78	0	Yes	No	0	3	0	1
R:R:A70	R:R:Y69	2.67	0	No	Yes	5	6	2	1
L:L:S12	R:R:R299	2.64	0	No	Yes	0	4	0	1
R:R:S94	R:R:W91	2.47	0	No	Yes	4	4	2	1
R:R:F195	R:R:Y152	2.06	0	No	Yes	7	7	2	1
L:L:A18	R:R:L32	1.58	0	No	Yes	0	4	0	1
L:L:P48	R:R:Q210	1.58	0	Yes	No	0	4	0	1
R:R:L118	R:R:S116	1.5	1	Yes	No	4	5	1	2
L:L:W25	R:R:E68	1.09	0	No	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9J1P_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.5
Number of Linked Nodes	415
Number of Links	472
Number of Hubs	70
Number of Links mediated by Hubs	269
Number of Communities	16
Number of Nodes involved in Communities	97
Number of Links involved in Communities	126

Path Summary
Number Of Nodes in MetaPath	61
Number Of Links MetaPath	60
Number of Shortest Paths	165585
Length Of Smallest Path	3
Average Path Length	18.8555
Length of Longest Path	43
Minimum Path Strength	1.32
Average Path Strength	7.25543
Maximum Path Strength	24.49
Minimum Path Correlation	0.7
Average Path Correlation	0.962774
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	59.4908
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	56.3385
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • dendrite • dendritic tree • neuron projection • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • plasma membrane region • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • glucagon receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • amide binding • peptide hormone binding • hormone binding • glucagon-like peptide 1 receptor activity • heart process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • regulation of blood pressure • positive regulation of blood pressure • response to psychosocial stress • cell surface receptor signaling pathway • behavior • learning or memory • cognition • transport • secretion • regulation of hormone levels • cell-cell signaling • export from cell • hormone secretion • establishment of localization • localization • secretion by cell • signal release • hormone transport • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • establishment of protein localization • cellular localization • nitrogen compound transport • protein targeting • protein transmembrane transport • establishment of localization in cell • post-translational protein targeting to membrane, translocation • intracellular protein localization • establishment of protein localization to endoplasmic reticulum • establishment of protein localization to membrane • intracellular protein transmembrane transport • intracellular transport • post-translational protein targeting to endoplasmic reticulum membrane • localization within membrane • protein targeting to membrane • transmembrane transport • establishment of protein localization to organelle • protein transport • macromolecule localization • intracellular protein transport • protein targeting to ER • negative regulation of blood pressure
SCOP2	Domain Identifier	• G protein-coupled receptor-like • FnI-like domain
SCOP2	Family Identifier	• G protein-coupled receptor-like • FnI-like domain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43220
Sequence	>9J1P_nogp_Chain_R T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S S P E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F R H L H C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S T A A Q Q H Q W D G L L S Y Q D S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S V L S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E D E G C W T R N S N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L M C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M D E H A R G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E V Q L E F R K S W E R W R L E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	7E14	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738	Gs/β1/γ2	2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7E14 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738		2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7DUQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738	Gs/β1/γ2	2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DUQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738		2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DUR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7DUR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	5VEW	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.7	2017-05-24	doi.org/10.1038/nature22378
	6LN2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.2	2020-03-18	doi.org/10.1038/s41467-020-14934-5
	6KJV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.1	2019-11-13	doi.org/10.1107/S2052252519013496
	5VEX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	NNC0640	-	3	2017-05-17	doi.org/10.1038/nature22378
	9IVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839	chim(NtGi1-Gs)/β2/γ2	3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	9IVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839		3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	6VCB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440	Gs/β1/γ2	3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	6VCB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440		3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	9IVG	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	chim(NtGi1-Gs)/β1/γ2	3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	9IVG (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-		3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	7RTB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-	Gs/β1/γ2	2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7RTB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-		2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7KI0	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI0 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	6X18	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X18 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	7LCI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCJ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	2.82	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCK	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	3.24	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7S15	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 134611223	-	-	3.8	2022-06-08	doi.org/10.1021/acs.jmedchem.1c01856
	9J1P	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-	chim(NtGi1-Gs)/β1/γ2	2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	9J1P (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-		2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	5VAI	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-	Gs/β1/γ2	4.1	2017-05-24	doi.org/10.1038/nature22394
	5VAI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-		4.1	2017-05-24	doi.org/10.1038/nature22394
	5NX2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	-	3.7	2017-06-14	doi.org/10.1038/nature22800
	6B3J	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-	Gs/β1/γ2	3.3	2018-02-21	doi.org/10.1038/nature25773
	6B3J (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-		3.3	2018-02-21	doi.org/10.1038/nature25773
	8WG7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WG7 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	7C2E	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-	Gs/β1/γ2	4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	7C2E (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-		4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	7LLL	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLL (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-	Gs/β1/γ2	3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-		3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7FIM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-	Gs/β1/γ2	3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-		3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBH	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7VBH (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-		3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7S1M	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-	Gs/β1/γ2	2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S1M (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-		2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	6XOX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-	chim(NtGi1-Gs)/β1/γ2	3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	6XOX (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-		3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	7RG9	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RG9 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7X8R	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-	Gs/β1/γ2	2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8R (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-		2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-	Gs/β1/γ2	3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-		3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	8JIP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-	chim(NtGi1-Gs)/β1/γ2	2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-		2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-	chim(NtGi1-Gs)/β1/γ2	2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-		2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIS	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-	chim(NtGi1-Gs)/β1/γ2	2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8JIS (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-		2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8YW3	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	9EBN	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBN (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-	Gs/β1/γ2	3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-		3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	8YWF	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ2	2.74	2025-04-16	To be published
	8YWF (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.74	2025-04-16	To be published
	9BYO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-	Gs/β1/γ2	2.31	2025-06-11	To be published
	9BYO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-		2.31	2025-06-11	To be published
	9C0K	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	2.72	2025-06-11	To be published
	9C0K (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		2.72	2025-06-11	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9J1P_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.