psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:G5	L:L:H2	3.18	No	Yes	1	0	0
2	L:L:H2	R:R:Q234	8.65	Yes	Yes	1	0	7
3	L:L:H2	R:R:V237	13.84	Yes	No	1	0	6
4	L:L:H2	R:R:Y241	5.44	Yes	Yes	1	0	8
5	L:L:H2	R:R:W306	10.58	Yes	Yes	1	0	6
6	L:L:E4	R:R:Y152	6.73	Yes	Yes	1	0	7
7	L:L:E4	R:R:R190	11.63	Yes	Yes	1	0	8
8	L:L:E4	R:R:L388	7.95	Yes	No	1	0	7
9	L:L:E4	R:R:T391	2.82	Yes	Yes	1	0	6
10	L:L:G5	L:L:T8	3.64	No	Yes	1	0	0
11	L:L:G5	R:R:W306	4.22	No	Yes	1	0	6
12	L:L:T6	R:R:D372	13.01	No	No	1	0	5
13	L:L:T6	R:R:R380	3.88	No	Yes	1	0	5
14	L:L:T6	R:R:L384	2.95	No	No	1	0	5
15	L:L:F7	L:L:V11	6.55	Yes	No	1	0	0
16	L:L:F7	R:R:L141	4.87	Yes	No	1	0	5
17	L:L:F7	R:R:L144	7.31	Yes	No	1	0	6
18	L:L:F7	R:R:Y145	3.09	Yes	Yes	1	0	5
19	L:L:F7	R:R:Y148	7.22	Yes	Yes	1	0	7
20	L:L:F7	R:R:L384	3.65	Yes	No	1	0	5
21	L:L:F7	R:R:L388	4.87	Yes	No	1	0	7
22	L:L:T8	R:R:K197	13.51	Yes	Yes	1	0	6
23	L:L:T8	R:R:M233	9.03	Yes	No	1	0	6
24	L:L:T8	R:R:T298	4.71	Yes	No	0	0	5
25	L:L:S9	R:R:N300	8.94	No	No	0	0	6
26	L:L:D10	R:R:R380	13.1	No	Yes	0	0	5
27	L:L:V11	R:R:L141	4.47	No	No	1	0	5
28	L:L:V11	W:W:?1	5.49	No	Yes	1	0	0
29	L:L:S12	R:R:Y205	5.09	No	Yes	0	0	3
30	L:L:S12	R:R:T298	9.59	No	No	0	0	5
31	L:L:S13	R:R:R299	6.59	No	No	0	0	4
32	L:L:Y14	R:R:P137	11.13	No	Yes	0	0	3
33	L:L:Y14	R:R:E138	10.1	No	No	0	0	2
34	L:L:L15	R:R:Y205	7.03	No	Yes	0	0	3
35	L:L:L15	W:W:?1	12.24	No	Yes	0	0	0
36	L:L:E16	R:R:L32	3.98	Yes	No	0	0	4
37	L:L:E16	R:R:Y205	7.86	Yes	Yes	0	0	3
38	L:L:E16	R:R:R299	11.63	Yes	No	0	0	4
39	L:L:K21	L:L:Q18	8.14	No	No	0	0	0
40	L:L:K21	R:R:E128	17.55	No	No	0	0	3
41	L:L:E22	R:R:A209	4.53	No	No	0	0	1
42	L:L:F23	L:L:W26	3.01	Yes	Yes	2	0	0
43	L:L:F23	L:L:L27	8.53	Yes	No	2	0	0
44	L:L:F23	R:R:V36	3.93	Yes	No	0	0	2
45	L:L:F23	R:R:W214	18.04	Yes	No	2	0	1
46	L:L:I24	R:R:L89	7.14	No	No	2	0	5
47	L:L:I24	R:R:W91	3.52	No	Yes	2	0	4
48	L:L:K29	L:L:W26	4.64	No	Yes	0	0	0
49	L:L:G32	L:L:W26	8.44	No	Yes	0	0	0
50	L:L:W26	R:R:H212	7.41	Yes	No	2	0	3
51	L:L:W26	R:R:W214	18.74	Yes	No	2	0	1
52	L:L:L27	R:R:W39	9.11	No	Yes	2	0	5
53	L:L:L27	R:R:Y88	3.52	No	Yes	2	0	5
54	L:L:V28	R:R:R121	5.23	No	Yes	2	0	6
55	L:L:V28	R:R:L123	4.47	No	No	2	0	5
56	R:R:E34	R:R:V30	2.85	Yes	No	0	4	2
57	R:R:P90	R:R:V30	3.53	No	No	0	4	2
58	R:R:E34	R:R:S31	2.87	Yes	No	0	4	4
59	R:R:L218	R:R:W33	5.69	No	No	0	3	3
60	R:R:D222	R:R:W33	6.7	No	No	3	6	3
61	R:R:E294	R:R:W33	21.81	No	No	3	4	3
62	R:R:E34	R:R:Q37	3.82	Yes	No	0	4	4
63	R:R:E34	R:R:K38	4.05	Yes	No	0	4	4
64	R:R:L218	R:R:V36	4.47	No	No	0	3	2
65	R:R:K38	R:R:W87	6.96	No	No	0	4	3
66	R:R:K38	R:R:Y88	3.58	No	Yes	0	4	5
67	R:R:R43	R:R:W39	9	No	Yes	0	4	5
68	R:R:E68	R:R:W39	4.36	No	Yes	0	4	5
69	R:R:W39	R:R:Y88	15.43	Yes	Yes	2	5	5
70	R:R:R40	R:R:R43	4.26	No	No	0	2	4
71	R:R:E41	R:R:Q45	12.74	No	No	0	4	5
72	R:R:C71	R:R:Y42	5.38	No	Yes	2	9	6
73	R:R:P86	R:R:Y42	6.95	No	Yes	2	8	6
74	R:R:W87	R:R:Y42	7.72	No	Yes	0	3	6
75	R:R:Y42	R:R:Y88	5.96	Yes	Yes	2	6	5
76	R:R:Q47	R:R:R44	5.84	No	No	0	3	3
77	R:R:Q45	R:R:R48	4.67	No	No	0	5	4
78	R:R:C46	R:R:S49	3.44	Yes	No	0	8	2
79	R:R:C46	R:R:L50	3.17	Yes	No	0	8	4
80	R:R:C46	R:R:F66	4.19	Yes	No	2	8	7
81	R:R:C46	R:R:C71	7.28	Yes	No	2	8	9
82	R:R:R64	R:R:S49	3.95	Yes	No	0	4	2
83	R:R:L50	R:R:R64	14.58	No	Yes	0	4	4
84	R:R:E52	R:R:T51	5.64	No	No	0	2	4
85	R:R:D53	R:R:R64	19.06	No	Yes	0	3	4
86	R:R:D74	R:R:P56	9.66	No	No	0	3	1
87	R:R:C62	R:R:F61	12.57	Yes	Yes	7	9	3
88	R:R:D74	R:R:F61	8.36	No	Yes	0	3	3
89	R:R:F61	R:R:G75	9.03	Yes	No	0	3	7
90	R:R:F61	R:R:P77	10.11	Yes	No	0	3	4
91	R:R:C104	R:R:F61	8.38	No	Yes	7	9	3
92	R:R:C62	R:R:R102	4.18	Yes	No	0	9	8
93	R:R:C104	R:R:C62	7.28	No	Yes	7	9	9
94	R:R:C62	R:R:G108	3.92	Yes	No	0	9	9
95	R:R:N63	R:R:T65	8.77	No	No	0	4	5
96	R:R:P73	R:R:R64	14.41	No	Yes	0	5	4
97	R:R:D74	R:R:R64	3.57	No	Yes	0	3	4
98	R:R:D67	R:R:T65	5.78	No	No	0	9	5
99	R:R:E68	R:R:F66	5.83	No	No	0	4	7
100	R:R:C71	R:R:F66	4.19	No	No	2	9	7
101	R:R:D67	R:R:W72	7.82	No	Yes	0	9	9
102	R:R:P86	R:R:Y69	5.56	No	Yes	2	8	6
103	R:R:Y69	R:R:Y88	4.96	Yes	Yes	2	6	5
104	R:R:L89	R:R:Y69	4.69	No	Yes	2	5	6
105	R:R:R121	R:R:Y69	5.14	Yes	Yes	2	6	6
106	R:R:L123	R:R:Y69	4.69	No	Yes	2	5	6
107	R:R:A70	R:R:W72	5.19	No	Yes	0	5	9
108	R:R:V83	R:R:W72	7.36	No	Yes	0	5	9
109	R:R:V100	R:R:W72	7.36	No	Yes	0	7	9
110	R:R:R102	R:R:W72	20.99	No	Yes	0	8	9
111	R:R:E76	R:R:P77	4.72	No	No	0	1	4
112	R:R:F103	R:R:G78	3.01	No	No	0	4	7
113	R:R:F80	R:R:Y101	8.25	No	No	0	4	5
114	R:R:F103	R:R:F80	4.29	No	No	0	4	4
115	R:R:C104	R:R:V81	5.12	No	No	0	9	6
116	R:R:H99	R:R:N82	3.83	Yes	No	8	4	4
117	R:R:N82	R:R:Y101	13.96	No	No	8	4	5
118	R:R:H99	R:R:S84	4.18	Yes	No	0	4	4
119	R:R:C126	R:R:C85	7.28	No	No	0	9	9
120	R:R:P86	R:R:Y88	5.56	No	Yes	2	8	5
121	R:R:L89	R:R:W91	26.19	No	Yes	2	5	4
122	R:R:P90	R:R:W91	8.11	No	Yes	0	4	4
123	R:R:S94	R:R:W91	4.94	No	Yes	0	4	4
124	R:R:E128	R:R:W91	8.72	No	Yes	0	3	4
125	R:R:S94	R:R:V95	4.85	No	No	0	4	5
126	R:R:G98	R:R:H99	3.18	No	Yes	0	4	4
127	R:R:E125	R:R:G98	4.91	No	No	0	5	4
128	R:R:H99	R:R:Y101	8.71	Yes	No	8	4	5
129	R:R:C126	R:R:V100	5.12	No	No	0	9	7
130	R:R:P119	R:R:R102	5.76	No	No	0	6	8
131	R:R:F103	R:R:W110	23.05	No	Yes	0	4	9
132	R:R:E107	R:R:T105	2.82	No	No	0	5	4
133	R:R:T105	R:R:W110	9.7	No	Yes	0	4	9
134	R:R:L111	R:R:W110	26.19	No	Yes	9	4	9
135	R:R:W110	R:R:W120	9.37	Yes	No	9	9	5
136	R:R:L111	R:R:W120	7.97	No	No	9	4	5
137	R:R:K113	R:R:Q112	12.2	No	No	0	4	3
138	R:R:Q112	R:R:S116	7.22	No	No	10	3	5
139	R:R:L118	R:R:Q112	14.64	No	No	10	4	3
140	R:R:D114	R:R:K113	5.53	No	No	0	4	4
141	R:R:L118	R:R:S116	3	No	No	10	4	5
142	R:R:P119	R:R:R121	2.88	No	Yes	0	6	6
143	R:R:D122	R:R:W120	3.35	No	No	0	7	5
144	R:R:L123	R:R:R121	9.72	No	Yes	2	5	6
145	R:R:D122	R:R:S124	4.42	No	No	0	7	5
146	R:R:P137	R:R:Q140	3.16	Yes	No	0	3	4
147	R:R:L141	R:R:P137	4.93	No	Yes	0	5	3
148	R:R:F381	R:R:Q140	12.88	Yes	No	0	4	4
149	R:R:L142	W:W:?1	21.42	No	Yes	0	3	0
150	R:R:F143	R:R:I147	7.54	No	No	0	4	6
151	R:R:L144	R:R:L384	4.15	No	No	1	6	5
152	R:R:Y145	R:R:Y148	8.94	Yes	Yes	1	5	7
153	R:R:T149	R:R:Y145	13.73	No	Yes	0	7	5
154	R:R:D198	R:R:Y145	14.94	No	Yes	1	7	5
155	R:R:Y145	W:W:?1	32.83	Yes	Yes	1	5	0
156	R:R:I147	R:R:S389	3.1	No	No	0	6	5
157	R:R:Y148	R:R:Y152	3.97	Yes	Yes	1	7	7
158	R:R:V194	R:R:Y148	5.05	No	Yes	1	7	7
159	R:R:K197	R:R:Y148	4.78	Yes	Yes	1	6	7
160	R:R:D198	R:R:Y148	8.05	No	Yes	1	7	7
161	R:R:L388	R:R:Y148	9.38	No	Yes	1	7	7
162	R:R:G151	R:R:S392	3.71	No	No	1	8	9
163	R:R:F393	R:R:G151	9.03	No	No	1	7	8
164	R:R:R190	R:R:Y152	7.2	Yes	Yes	1	8	7
165	R:R:A191	R:R:Y152	4	No	Yes	0	7	7
166	R:R:V194	R:R:Y152	7.57	No	Yes	1	7	7
167	R:R:S392	R:R:Y152	7.63	No	Yes	1	9	7
168	R:R:L154	R:R:L396	4.15	No	No	0	5	7
169	R:R:G395	R:R:S155	3.71	No	No	0	9	9
170	R:R:F184	R:R:L159	6.09	Yes	No	0	8	9
171	R:R:I188	R:R:L159	2.85	Yes	No	0	7	9
172	R:R:A399	R:R:L159	3.15	No	No	0	8	9
173	R:R:F404	R:R:I161	3.77	No	No	0	8	4
174	R:R:A162	R:R:C403	3.61	No	Yes	0	9	9
175	R:R:L181	R:R:S163	3	No	No	0	6	6
176	R:R:F184	R:R:S163	3.96	Yes	No	0	8	6
177	R:R:I188	R:R:S163	3.1	Yes	No	0	7	6
178	R:R:F169	R:R:I165	5.02	No	No	11	7	8
179	R:R:F413	R:R:I165	6.28	No	No	11	5	8
180	R:R:L166	R:R:N177	10.98	No	Yes	0	8	9
181	R:R:C403	R:R:L166	4.76	Yes	No	0	9	8
182	R:R:L167	R:R:L181	4.15	No	No	0	3	6
183	R:R:E412	R:R:F169	24.49	No	No	0	8	7
184	R:R:F169	R:R:F413	8.57	No	No	11	7	5
185	R:R:H173	R:R:R170	5.64	No	No	0	7	8
186	R:R:L172	R:R:N177	5.49	No	Yes	0	9	9
187	R:R:E408	R:R:L172	3.98	No	No	0	9	9
188	R:R:L172	R:R:V409	2.98	No	No	0	9	9
189	R:R:H173	R:R:Y178	8.71	No	No	0	7	6
190	R:R:C174	R:R:R176	4.18	No	Yes	4	8	9
191	R:R:C174	R:R:N177	4.72	No	Yes	4	8	9
192	R:R:T175	R:R:Y250	7.49	No	Yes	4	7	8
193	R:R:E262	R:R:T175	9.88	No	No	4	6	7
194	R:R:F266	R:R:T175	3.89	Yes	No	0	6	7
195	R:R:N177	R:R:R176	4.82	Yes	Yes	4	9	9
196	R:R:H180	R:R:R176	6.77	No	Yes	0	9	9
197	R:R:R176	R:R:Y250	3.09	Yes	Yes	4	9	8
198	R:R:F266	R:R:Y178	7.22	Yes	No	0	6	6
199	R:R:I179	R:R:Y250	13.3	No	Yes	0	8	8
200	R:R:F266	R:R:I179	5.02	Yes	No	0	6	8
201	R:R:E247	R:R:H180	3.69	No	No	0	9	9
202	R:R:N182	R:R:W243	11.3	No	Yes	0	9	9
203	R:R:L183	R:R:S186	4.5	No	No	0	9	9
204	R:R:F187	R:R:L183	7.31	Yes	No	0	8	9
205	R:R:E247	R:R:L183	15.9	No	No	0	9	9
206	R:R:F184	R:R:V398	3.93	Yes	No	0	8	9
207	R:R:C403	R:R:F184	4.19	Yes	Yes	0	9	8
208	R:R:N240	R:R:S186	7.45	No	No	0	9	9
209	R:R:S186	R:R:W243	7.41	No	Yes	0	9	9
210	R:R:F187	R:R:N240	21.75	Yes	No	0	8	9
211	R:R:F187	R:R:Q394	10.54	Yes	Yes	0	8	9
212	R:R:F187	R:R:G395	6.02	Yes	No	0	8	9
213	R:R:F187	R:R:V398	3.93	Yes	No	0	8	9
214	R:R:C236	R:R:L189	4.76	No	No	0	5	7
215	R:R:R190	R:R:V237	11.77	Yes	No	1	8	6
216	R:R:N240	R:R:R190	13.26	No	Yes	0	9	8
217	R:R:R190	R:R:Y241	13.38	Yes	Yes	1	8	8
218	R:R:R190	R:R:T391	5.17	Yes	Yes	1	8	6
219	R:R:I196	R:R:L192	2.85	No	No	0	5	3
220	R:R:L232	R:R:S193	7.51	No	No	12	5	6
221	R:R:C236	R:R:S193	6.89	No	No	12	5	6
222	R:R:I196	R:R:V229	4.61	No	No	0	5	7
223	R:R:D198	R:R:K197	9.68	No	Yes	1	7	6
224	R:R:K197	R:R:L201	2.82	Yes	No	1	6	7
225	R:R:F230	R:R:K197	4.96	No	Yes	1	5	6
226	R:R:K197	R:R:M233	7.2	Yes	No	1	6	6
227	R:R:F230	R:R:L201	3.65	No	No	1	5	7
228	R:R:L201	W:W:?1	3.06	No	Yes	1	7	0
229	R:R:K202	R:R:S206	3.06	No	No	1	4	4
230	R:R:K202	W:W:?1	18.71	No	Yes	1	4	0
231	R:R:W203	R:R:Y220	15.43	No	Yes	0	3	3
232	R:R:M204	R:R:Y205	8.38	Yes	Yes	0	3	3
233	R:R:L217	R:R:M204	2.83	No	Yes	0	4	3
234	R:R:M204	R:R:Y220	4.79	Yes	Yes	0	3	3
235	R:R:M204	R:R:Q221	4.08	Yes	No	3	3	4
236	R:R:C296	R:R:M204	4.86	Yes	Yes	3	9	3
237	R:R:S206	W:W:?1	8.85	No	Yes	1	4	0
238	R:R:Q210	R:R:T207	2.83	No	No	13	4	3
239	R:R:Q211	R:R:T207	5.67	No	No	13	4	3
240	R:R:A208	R:R:L217	4.73	No	No	0	4	4
241	R:R:Q210	R:R:Q211	7.68	No	No	13	4	4
242	R:R:Q211	R:R:Q213	10.24	No	No	0	4	4
243	R:R:H212	R:R:W214	9.52	No	No	2	3	1
244	R:R:S223	R:R:Y220	6.36	No	Yes	0	4	3
245	R:R:S225	R:R:Y220	5.09	No	Yes	0	3	3
246	R:R:C226	R:R:Y220	6.72	No	Yes	0	9	3
247	R:R:C296	R:R:Q221	3.05	Yes	No	3	9	4
248	R:R:D222	R:R:E294	5.2	No	No	3	6	4
249	R:R:C226	R:R:C296	7.28	No	Yes	0	9	9
250	R:R:D293	R:R:R227	15.48	No	No	6	7	8
251	R:R:R227	R:R:W297	30.99	No	Yes	6	8	8
252	R:R:F230	R:R:T298	12.97	No	No	0	5	5
253	R:R:L231	R:R:V281	4.47	No	No	0	5	6
254	R:R:L231	R:R:W297	3.42	No	Yes	0	5	8
255	R:R:C236	R:R:L232	3.17	No	No	12	5	5
256	R:R:Q234	R:R:W284	8.76	Yes	Yes	1	7	8
257	R:R:Q234	R:R:W306	7.67	Yes	Yes	1	7	6
258	R:R:I309	R:R:Q234	4.12	Yes	Yes	1	7	7
259	R:R:W274	R:R:Y235	7.72	Yes	No	0	9	9
260	R:R:V237	R:R:Y241	3.79	No	Yes	1	6	8
261	R:R:A238	R:R:F280	4.16	No	Yes	0	6	5
262	R:R:A239	R:R:W274	3.89	No	Yes	0	8	9
263	R:R:A239	R:R:P277	3.74	No	No	0	8	9
264	R:R:I313	R:R:Y241	9.67	No	Yes	0	7	8
265	R:R:E364	R:R:Y241	10.1	Yes	Yes	1	8	8
266	R:R:T391	R:R:Y241	3.75	Yes	Yes	1	6	8
267	R:R:V276	R:R:Y242	5.05	No	No	0	3	6
268	R:R:P277	R:R:Y242	11.13	No	No	0	9	6
269	R:R:F280	R:R:Y242	11.35	Yes	No	0	5	6
270	R:R:V246	R:R:W243	7.36	No	Yes	0	8	9
271	R:R:G273	R:R:W243	8.44	No	Yes	0	9	9
272	R:R:W243	R:R:W274	18.74	Yes	Yes	0	9	9
273	R:R:L244	R:R:Q394	7.99	No	Yes	0	9	9
274	R:R:A316	R:R:L245	3.15	No	No	0	7	8
275	R:R:L245	R:R:V319	2.98	No	No	0	8	6
276	R:R:L245	R:R:N320	12.36	No	No	0	8	9
277	R:R:V246	R:R:Y269	3.79	No	Yes	0	8	7
278	R:R:I272	R:R:V246	3.07	No	No	0	6	8
279	R:R:E247	R:R:L359	13.25	No	No	0	9	9
280	R:R:G248	R:R:L360	3.42	No	Yes	0	8	9
281	R:R:V249	R:R:Y269	6.31	No	Yes	0	6	7
282	R:R:I323	R:R:V249	3.07	No	No	0	8	6
283	R:R:L254	R:R:Y250	9.38	No	Yes	0	8	8
284	R:R:E262	R:R:Y250	3.37	No	Yes	4	6	8
285	R:R:Y250	R:R:Y269	5.96	Yes	Yes	0	8	7
286	R:R:L251	R:R:V327	2.98	No	No	0	9	9
287	R:R:A256	R:R:Y252	9.34	No	No	0	6	8
288	R:R:I323	R:R:Y252	3.63	No	No	0	8	8
289	R:R:R326	R:R:Y252	5.14	No	No	0	8	8
290	R:R:F257	R:R:T253	6.49	No	No	0	5	7
291	R:R:T253	R:R:Y269	6.24	No	Yes	0	7	7
292	R:R:F260	R:R:L254	3.65	No	No	0	7	8
293	R:R:L255	R:R:V327	2.98	No	No	0	8	9
294	R:R:I330	R:R:L255	7.14	No	No	0	9	8
295	R:R:E262	R:R:F260	5.83	No	No	0	6	7
296	R:R:F260	R:R:I265	5.02	No	No	0	7	5
297	R:R:Q263	R:R:R267	10.51	No	No	0	5	4
298	R:R:L268	R:R:W264	3.42	No	No	0	2	5
299	R:R:I265	R:R:Y269	4.84	No	Yes	0	5	7
300	R:R:F266	R:R:V270	6.55	Yes	No	0	6	5
301	R:R:I272	R:R:L268	2.85	No	No	0	6	2
302	R:R:I272	R:R:V276	3.07	No	No	0	6	3
303	R:R:L278	R:R:V282	2.98	No	No	0	3	3
304	R:R:F280	R:R:I309	5.02	Yes	Yes	0	5	7
305	R:R:F280	R:R:P312	21.67	Yes	No	0	5	8
306	R:R:I309	R:R:V281	3.07	Yes	No	0	7	6
307	R:R:P283	R:R:V282	3.53	No	No	0	5	3
308	R:R:G285	R:R:W284	2.81	No	Yes	0	5	8
309	R:R:K288	R:R:W284	11.6	No	Yes	0	8	8
310	R:R:I308	R:R:W284	3.52	No	Yes	0	8	8
311	R:R:I309	R:R:W284	5.87	Yes	Yes	1	7	8
312	R:R:G285	R:R:W297	2.81	No	Yes	0	5	8
313	R:R:V287	R:R:Y291	3.79	No	No	0	4	3
314	R:R:K288	R:R:W297	17.4	No	Yes	0	8	8
315	R:R:D293	R:R:Y289	4.6	No	No	6	7	3
316	R:R:W297	R:R:Y289	3.86	Yes	No	6	8	3
317	R:R:L290	R:R:Y291	3.52	No	No	0	3	3
318	R:R:Y291	R:R:Y305	8.94	No	No	0	3	4
319	R:R:E292	R:R:S301	2.87	No	No	0	6	3
320	R:R:E292	R:R:Y305	7.86	No	No	0	6	4
321	R:R:D293	R:R:W297	6.7	No	Yes	6	7	8
322	R:R:N300	R:R:W306	12.43	No	Yes	0	6	6
323	R:R:N302	R:R:Y305	16.28	No	No	0	5	4
324	R:R:E373	R:R:M303	13.53	Yes	No	0	4	5
325	R:R:I309	R:R:W306	7.05	Yes	Yes	1	7	6
326	R:R:R310	R:R:W306	9	Yes	Yes	0	6	6
327	R:R:L307	R:R:R310	6.07	No	Yes	0	7	6
328	R:R:L307	R:R:L311	5.54	No	No	0	7	4
329	R:R:M371	R:R:R310	14.89	No	Yes	0	7	6
330	R:R:E373	R:R:R310	9.3	Yes	Yes	0	4	6
331	R:R:E364	R:R:I317	6.83	Yes	No	0	8	7
332	R:R:I317	R:R:V365	3.07	No	No	0	7	6
333	R:R:L360	R:R:N320	4.12	Yes	No	0	9	9
334	R:R:F321	R:R:V325	3.93	No	No	0	6	5
335	R:R:F321	R:R:T362	5.19	No	Yes	5	6	7
336	R:R:F321	R:R:V365	14.42	No	No	5	6	6
337	R:R:I323	R:R:L360	2.85	No	Yes	0	8	9
338	R:R:F324	R:R:I328	3.77	No	No	0	9	7
339	R:R:F324	R:R:I357	5.02	No	No	5	9	8
340	R:R:F324	R:R:T362	14.27	No	Yes	5	9	7
341	R:R:L356	R:R:V327	5.96	No	No	0	9	9
342	R:R:I328	R:R:T353	4.56	No	No	0	7	9
343	R:R:I330	R:R:K334	2.91	No	No	0	9	9
344	R:R:L349	R:R:V331	2.98	No	No	0	9	8
345	R:R:S352	R:R:V331	6.46	No	No	0	9	8
346	R:R:K336	R:R:V332	3.04	No	No	0	6	6
347	R:R:L349	R:R:V332	4.47	No	No	0	9	6
348	R:R:I345	R:R:L335	4.28	No	No	0	5	8
349	R:R:L335	R:R:R348	4.86	No	No	0	8	8
350	R:R:D344	R:R:K346	8.3	No	No	0	7	6
351	R:R:K351	R:R:R348	11.14	No	No	0	8	8
352	R:R:L354	R:R:T353	2.95	No	No	0	8	9
353	R:R:T355	R:R:Y402	6.24	No	No	0	8	8
354	R:R:L356	R:R:L360	5.54	No	Yes	0	9	9
355	R:R:I357	R:R:P358	3.39	No	Yes	0	8	9
356	R:R:I357	R:R:T362	6.08	No	Yes	5	8	7
357	R:R:M397	R:R:P358	8.39	No	Yes	0	5	9
358	R:R:P358	R:R:V398	3.53	Yes	No	0	9	9
359	R:R:L401	R:R:P358	3.28	No	Yes	0	8	9
360	R:R:L359	R:R:Y402	9.38	No	No	0	9	8
361	R:R:G361	R:R:H363	3.18	No	Yes	1	9	8
362	R:R:G361	R:R:Q394	3.29	No	Yes	1	9	9
363	R:R:T362	R:R:V365	4.76	Yes	No	5	7	6
364	R:R:E364	R:R:H363	9.85	Yes	Yes	1	8	8
365	R:R:F390	R:R:H363	4.53	No	Yes	0	6	8
366	R:R:H363	R:R:T391	5.48	Yes	Yes	1	8	6
367	R:R:H363	R:R:Q394	6.18	Yes	Yes	1	8	9
368	R:R:E364	R:R:E387	8.88	Yes	No	0	8	8
369	R:R:E364	R:R:T391	7.06	Yes	Yes	1	8	6
370	R:R:F367	R:R:I366	8.79	Yes	No	0	7	6
371	R:R:F367	R:R:V370	5.24	Yes	No	0	7	5
372	R:R:F367	R:R:T386	7.78	Yes	No	0	7	4
373	R:R:E387	R:R:F367	8.16	No	Yes	0	8	7
374	R:R:L379	R:R:V370	2.98	No	No	0	3	5
375	R:R:D372	R:R:E373	5.2	No	Yes	0	5	4
376	R:R:D372	R:R:R380	10.72	No	Yes	1	5	5
377	R:R:F381	R:R:T378	3.89	Yes	No	0	4	2
378	R:R:F385	R:R:S389	7.93	No	No	0	6	5
379	R:R:Q394	R:R:T391	4.25	Yes	Yes	1	9	6
380	R:R:F393	R:R:S392	3.96	No	No	1	7	9
381	R:R:I400	R:R:L396	2.85	No	No	0	6	7
382	R:R:I400	R:R:V405	3.07	No	No	0	6	6
383	R:R:L401	R:R:Y402	3.52	No	No	0	8	8
384	R:R:N406	R:R:V409	5.91	No	No	0	9	9
385	R:R:E412	R:R:S416	4.31	No	No	0	8	5
386	R:R:K415	R:R:R419	4.95	No	No	0	7	7
387	R:R:E418	R:R:W417	10.9	No	No	14	4	5
388	R:R:R421	R:R:W417	11	No	No	14	4	5
389	R:R:E418	R:R:R421	5.82	No	No	14	4	4
390	R:R:R421	R:R:W420	7	No	No	0	4	4
391	R:R:C403	R:R:F404	2.79	Yes	No	0	9	8
392	R:R:A375	R:R:R380	2.77	No	Yes	0	4	5
393	R:R:L307	R:R:N304	2.75	No	No	0	7	3
394	R:R:E292	R:R:K288	2.7	No	No	0	6	8
395	R:R:D114	R:R:N115	2.69	No	No	0	4	4
396	R:R:F315	R:R:V319	2.62	No	No	0	4	6
397	R:R:F413	R:R:V409	2.62	No	No	0	5	9
398	L:L:F23	R:R:T35	2.59	Yes	No	0	0	5
399	R:R:F195	R:R:T149	2.59	No	No	0	7	7
400	R:R:E294	R:R:Q221	2.55	No	No	3	4	4
401	R:R:F156	R:R:I188	2.51	No	Yes	0	7	7
402	R:R:F367	R:R:I382	2.51	Yes	No	0	7	4
403	R:R:F381	R:R:I382	2.51	Yes	No	0	4	4
404	R:R:F367	R:R:K383	2.48	Yes	No	0	7	7
405	R:R:S261	R:R:W264	2.47	No	No	0	7	5
406	R:R:E408	R:R:H171	2.46	No	No	0	9	7
407	R:R:T207	R:R:W203	2.43	No	No	0	3	3
408	R:R:L224	R:R:R227	2.43	No	No	0	3	8
409	R:R:I146	R:R:Y145	2.42	No	Yes	0	4	5
410	R:R:Q47	R:R:R43	2.34	No	No	0	3	4
411	R:R:Q45	R:R:R44	2.34	No	No	0	5	3
412	R:R:E52	R:R:R48	2.33	No	No	0	2	4
413	R:R:E373	R:R:R376	2.33	Yes	No	0	4	5
414	R:R:L189	R:R:W274	2.28	No	Yes	0	7	9
415	R:R:F381	R:R:F385	2.14	Yes	No	0	4	6
416	R:R:C85	R:R:G98	1.96	No	No	0	9	4
417	R:R:C296	R:R:G295	1.96	Yes	No	0	9	4
418	R:R:P54	R:R:P55	1.95	No	No	0	2	1
419	R:R:P55	R:R:P56	1.95	No	No	0	1	1
420	L:L:A20	R:R:P90	1.87	No	No	0	0	4
421	R:R:A106	R:R:P77	1.87	No	No	0	1	4
422	R:R:G216	R:R:S219	1.86	No	No	0	2	5
423	R:R:G151	R:R:V150	1.84	No	No	0	8	5
424	R:R:A158	R:R:A399	1.79	No	No	0	7	8
425	R:R:P137	R:R:S136	1.78	Yes	No	0	3	1
426	R:R:P96	R:R:V95	1.77	No	No	0	3	5
427	R:R:G168	R:R:L167	1.71	No	No	0	1	3
428	R:R:G275	R:R:L278	1.71	No	No	0	6	3
429	R:R:A200	R:R:V229	1.7	No	No	0	4	7
430	L:L:E16	L:L:G17	1.64	Yes	No	0	0	0
431	R:R:L118	R:R:P119	1.64	No	No	0	4	6
432	L:L:A3	R:R:K383	1.61	No	No	0	0	7
433	L:L:A19	R:R:L32	1.58	No	No	0	0	4
434	R:R:A368	R:R:L314	1.58	No	No	0	6	4
435	R:R:C347	R:R:D344	1.56	No	No	0	7	7
436	R:R:I328	R:R:S352	1.55	No	No	0	7	9
437	R:R:I188	R:R:V160	1.54	Yes	No	0	7	3
438	R:R:I286	R:R:V282	1.54	No	No	0	4	3
439	R:R:I286	R:R:V287	1.54	No	No	0	4	4
440	R:R:K334	R:R:S333	1.53	No	No	0	9	7
441	R:R:L396	R:R:S155	1.5	No	No	0	7	9
442	R:R:K351	R:R:T355	1.5	No	No	0	8	8
443	R:R:I196	R:R:L232	1.43	No	No	0	5	5
444	R:R:K415	R:R:L411	1.41	No	No	0	7	4
445	R:R:A153	R:R:F195	1.39	No	No	0	6	7
446	R:R:C329	R:R:R326	1.39	No	No	0	7	8
447	R:R:L311	R:R:L314	1.38	No	No	0	4	4
448	R:R:L411	R:R:N407	1.37	No	No	0	4	6
449	R:R:A185	R:R:W274	1.3	No	Yes	0	3	9
450	L:L:E22	R:R:Q210	1.27	No	No	0	0	4
451	R:R:E373	R:R:H374	1.23	Yes	No	0	4	3
452	R:R:L411	R:R:R414	1.21	No	No	0	4	6
453	R:R:F266	R:R:Q263	1.17	Yes	No	0	6	5
454	L:L:R31	L:L:W26	1	No	Yes	0	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:H2	8.338	5	1	0
2	L:L:E4	7.2825	4	1	0
3	L:L:F7	5.36571	7	1	0
4	L:L:T8	7.7225	4	1	0
5	L:L:E16	6.2775	4	0	0
6	L:L:F23	7.22	5	2	0
7	L:L:W26	7.20667	6	2	0
8	R:R:E34	3.3975	4	0	4
9	R:R:W39	9.475	4	2	5
10	R:R:Y42	6.5025	4	2	6
11	R:R:C46	4.52	4	2	8
12	R:R:F61	9.69	5	7	3
13	R:R:C62	6.9875	4	7	9
14	R:R:R64	11.114	5	0	4
15	R:R:Y69	5.008	5	2	6
16	R:R:W72	9.744	5	0	9
17	R:R:Y88	6.50167	6	2	5
18	R:R:W91	10.296	5	2	4
19	R:R:H99	4.975	4	8	4
20	R:R:W110	17.0775	4	9	9
21	R:R:R121	5.7425	4	2	6
22	R:R:P137	5.25	4	0	3
23	R:R:Y145	12.6583	6	1	5
24	R:R:Y148	6.77	7	1	7
25	R:R:Y152	6.18333	6	1	7
26	R:R:R176	4.715	4	4	9
27	R:R:N177	6.5025	4	4	9
28	R:R:F184	4.5425	4	0	8
29	R:R:F187	9.91	5	0	8
30	R:R:I188	2.5	4	0	7
31	R:R:R190	10.4017	6	1	8
32	R:R:K197	7.15833	6	1	6
33	R:R:M204	4.988	5	3	3
34	R:R:Y205	7.09	4	0	3
35	R:R:Y220	7.678	5	0	3
36	R:R:Q234	7.3	4	1	7
37	R:R:Y241	7.68833	6	1	8
38	R:R:W243	10.65	5	0	9
39	R:R:Y250	7.09833	6	4	8
40	R:R:F266	4.77	5	0	6
41	R:R:Y269	5.428	5	0	7
42	R:R:W274	6.786	5	0	9
43	R:R:F280	10.55	4	0	5
44	R:R:W284	6.512	5	1	8
45	R:R:C296	4.2875	4	3	9
46	R:R:W297	10.8633	6	6	8
47	R:R:W306	8.49167	6	1	6
48	R:R:I309	5.026	5	1	7
49	R:R:R310	9.815	4	0	6
50	R:R:P358	4.6475	4	0	9
51	R:R:L360	3.9825	4	0	9
52	R:R:T362	7.575	4	5	7
53	R:R:H363	5.844	5	1	8
54	R:R:E364	8.544	5	1	8
55	R:R:F367	5.82667	6	0	7
56	R:R:E373	6.318	5	0	4
57	R:R:R380	7.6175	4	1	5
58	R:R:F381	5.355	4	0	4
59	R:R:T391	4.755	6	1	6
60	R:R:Q394	6.45	5	1	9
61	R:R:C403	3.8375	4	0	9
62	W:W:?1	14.6571	7	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:G5	L:L:H2	20.6178	3.18	No	Yes	1	0	0
2	L:L:H2	R:R:Q234	22.7226	8.65	Yes	Yes	1	0	7
3	L:L:G5	R:R:W306	26.2037	4.22	No	Yes	1	0	6
4	L:L:H2	R:R:Y241	27.9482	5.44	Yes	Yes	1	0	8
5	R:R:R190	R:R:Y241	12.3742	13.38	Yes	Yes	1	8	8
6	L:L:E4	R:R:T391	12.3758	2.82	Yes	Yes	1	0	6
7	R:R:R190	R:R:Y152	55.9611	7.2	Yes	Yes	1	8	7
8	L:L:G5	L:L:T8	46.1721	3.64	No	Yes	1	0	0
9	R:R:Y148	R:R:Y152	56.7986	3.97	Yes	Yes	1	7	7
10	R:R:R310	R:R:W306	13.1737	9	Yes	Yes	0	6	6
11	L:L:V11	W:W:?1	10.1746	5.49	No	Yes	1	0	0
12	R:R:Y145	R:R:Y148	52.4342	8.94	Yes	Yes	1	5	7
13	L:L:T8	R:R:T298	41.3131	4.71	Yes	No	0	0	5
14	L:L:S12	R:R:T298	40.8643	9.59	No	No	0	0	5
15	L:L:S12	R:R:Y205	39.6745	5.09	No	Yes	0	0	3
16	R:R:L141	R:R:P137	10.7055	4.93	No	Yes	0	5	3
17	L:L:L15	W:W:?1	64.0626	12.24	No	Yes	0	0	0
18	L:L:L15	R:R:Y205	63.7165	7.03	No	Yes	0	0	3
19	R:R:M204	R:R:Y205	100	8.38	Yes	Yes	0	3	3
20	R:R:M204	R:R:Q221	91.3961	4.08	Yes	No	3	3	4
21	R:R:E294	R:R:Q221	91.543	2.55	No	No	3	4	4
22	R:R:E294	R:R:W33	90.3611	21.81	No	No	3	4	3
23	R:R:L218	R:R:W33	90.0735	5.69	No	No	0	3	3
24	R:R:L218	R:R:V36	89.5773	4.47	No	No	0	3	2
25	L:L:F23	R:R:V36	89.078	3.93	Yes	No	0	0	2
26	L:L:F23	L:L:L27	84.4418	8.53	Yes	No	2	0	0
27	L:L:L27	R:R:Y88	63.1034	3.52	No	Yes	2	0	5
28	R:R:Y69	R:R:Y88	43.7292	4.96	Yes	Yes	2	6	5
29	L:L:L27	R:R:W39	20.8011	9.11	No	Yes	2	0	5
30	R:R:R121	R:R:Y69	34.3762	5.14	Yes	Yes	2	6	6
31	R:R:Y42	R:R:Y88	15.1442	5.96	Yes	Yes	2	6	5
32	R:R:E68	R:R:W39	14.2893	4.36	No	Yes	0	4	5
33	R:R:C71	R:R:Y42	14.1708	5.38	No	Yes	2	9	6
34	R:R:E68	R:R:F66	13.5214	5.83	No	No	0	4	7
35	R:R:C46	R:R:F66	12.8135	4.19	Yes	No	2	8	7
36	R:R:C46	R:R:C71	13.1469	7.28	Yes	No	2	8	9
37	R:R:C46	R:R:S49	12.2715	3.44	Yes	No	0	8	2
38	R:R:C46	R:R:L50	12.2715	3.17	Yes	No	0	8	4
39	R:R:R64	R:R:S49	10.813	3.95	Yes	No	0	4	2
40	R:R:L50	R:R:R64	10.813	14.58	No	Yes	0	4	4
41	R:R:D74	R:R:R64	12.6886	3.57	No	Yes	0	3	4
42	R:R:P119	R:R:R121	33.0426	2.88	No	Yes	0	6	6
43	R:R:P119	R:R:R102	27.9987	5.76	No	No	0	6	8
44	R:R:R102	R:R:W72	20.8359	20.99	No	Yes	0	8	9
45	R:R:V100	R:R:W72	16.0259	7.36	No	Yes	0	7	9
46	R:R:C126	R:R:V100	15.2153	5.12	No	No	0	9	7
47	R:R:C126	R:R:C85	14.3968	7.28	No	No	0	9	9
48	R:R:C85	R:R:G98	13.5751	1.96	No	No	0	9	4
49	R:R:G98	R:R:H99	11.9223	3.18	No	Yes	0	4	4
50	R:R:E364	R:R:Y241	13.4171	10.1	Yes	Yes	1	8	8
51	R:R:E364	R:R:E387	13.2986	8.88	Yes	No	0	8	8
52	R:R:E387	R:R:F367	12.2478	8.16	No	Yes	0	8	7
53	R:R:N240	R:R:R190	73.1153	13.26	No	Yes	0	9	8
54	R:R:F187	R:R:N240	37.9332	21.75	Yes	No	0	8	9
55	R:R:Q394	R:R:T391	15.0083	4.25	Yes	Yes	1	9	6
56	R:R:F187	R:R:Q394	13.7758	10.54	Yes	Yes	0	8	9
57	R:R:F187	R:R:V398	32.8324	3.93	Yes	No	0	8	9
58	R:R:F184	R:R:V398	23.2836	3.93	Yes	No	0	8	9
59	R:R:C403	R:R:F184	12.5986	4.19	Yes	Yes	0	9	8
60	R:R:N240	R:R:S186	40.5689	7.45	No	No	0	9	9
61	R:R:L183	R:R:S186	14.0223	4.5	No	No	0	9	9
62	R:R:E247	R:R:L183	26.4865	15.9	No	No	0	9	9
63	R:R:E247	R:R:H180	17.6013	3.69	No	No	0	9	9
64	R:R:H180	R:R:R176	16.3957	6.77	No	Yes	0	9	9
65	R:R:N177	R:R:R176	15.2074	4.82	Yes	Yes	4	9	9
66	R:R:L172	R:R:N177	18.0912	5.49	No	Yes	0	9	9
67	R:R:L172	R:R:V409	12.6965	2.98	No	No	0	9	9
68	R:R:F187	R:R:L183	19.477	7.31	Yes	No	0	8	9
69	R:R:S186	R:R:W243	32.7297	7.41	No	Yes	0	9	9
70	R:R:V246	R:R:W243	25.0438	7.36	No	Yes	0	8	9
71	R:R:V246	R:R:Y269	28.6735	3.79	No	Yes	0	8	7
72	R:R:Y250	R:R:Y269	14.5896	5.96	Yes	Yes	0	8	7
73	R:R:I309	R:R:W306	19.3253	7.05	Yes	Yes	1	7	6
74	R:R:F280	R:R:I309	12.4374	5.02	Yes	Yes	0	5	7
75	R:R:F280	R:R:Y242	10.271	11.35	Yes	No	0	5	6
76	R:R:Q234	R:R:W284	28.5929	8.76	Yes	Yes	1	7	8
77	R:R:I309	R:R:W284	12.3931	5.87	Yes	Yes	1	7	8
78	R:R:K288	R:R:W284	28.457	11.6	No	Yes	0	8	8
79	R:R:V249	R:R:Y269	15.1995	6.31	No	Yes	0	6	7
80	R:R:I323	R:R:V249	14.4695	3.07	No	No	0	8	6
81	R:R:I323	R:R:L360	10.7719	2.85	No	Yes	0	8	9
82	R:R:E247	R:R:L359	10.369	13.25	No	No	0	9	9
83	R:R:E292	R:R:K288	19.1499	2.7	No	No	0	6	8
84	R:R:E292	R:R:Y305	15.9896	7.86	No	No	0	6	4
85	R:R:Y291	R:R:Y305	12.8166	8.94	No	No	0	3	4
86	R:R:T355	R:R:Y402	10.8177	6.24	No	No	0	8	8
87	R:R:P358	R:R:V398	12.0155	3.53	Yes	No	0	9	9
88	L:L:E4	R:R:L388	15.1173	7.95	Yes	No	1	0	7
89	L:L:F7	R:R:L388	12.3205	4.87	Yes	No	1	0	7
90	R:R:Y145	W:W:?1	54.8534	32.83	Yes	Yes	1	5	0

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:H2	R:R:Q234	8.65	1	Yes	Yes	0	7	0	1
L:L:H2	R:R:V237	13.84	1	Yes	No	0	6	0	1
L:L:H2	R:R:Y241	5.44	1	Yes	Yes	0	8	0	1
L:L:H2	R:R:W306	10.58	1	Yes	Yes	0	6	0	1
L:L:E4	R:R:Y152	6.73	1	Yes	Yes	0	7	0	1
L:L:E4	R:R:R190	11.63	1	Yes	Yes	0	8	0	1
L:L:E4	R:R:L388	7.95	1	Yes	No	0	7	0	1
L:L:E4	R:R:T391	2.82	1	Yes	Yes	0	6	0	1
L:L:G5	R:R:W306	4.22	1	No	Yes	0	6	0	1
L:L:T6	R:R:D372	13.01	1	No	No	0	5	0	1
L:L:T6	R:R:R380	3.88	1	No	Yes	0	5	0	1
L:L:T6	R:R:L384	2.95	1	No	No	0	5	0	1
L:L:F7	R:R:L141	4.87	1	Yes	No	0	5	0	1
L:L:F7	R:R:L144	7.31	1	Yes	No	0	6	0	1
L:L:F7	R:R:Y145	3.09	1	Yes	Yes	0	5	0	1
L:L:F7	R:R:Y148	7.22	1	Yes	Yes	0	7	0	1
L:L:F7	R:R:L384	3.65	1	Yes	No	0	5	0	1
L:L:F7	R:R:L388	4.87	1	Yes	No	0	7	0	1
L:L:T8	R:R:K197	13.51	1	Yes	Yes	0	6	0	1
L:L:T8	R:R:M233	9.03	1	Yes	No	0	6	0	1
L:L:T8	R:R:T298	4.71	1	Yes	No	0	5	0	1
L:L:S9	R:R:N300	8.94	0	No	No	0	6	0	1
L:L:D10	R:R:R380	13.1	0	No	Yes	0	5	0	1
L:L:V11	R:R:L141	4.47	1	No	No	0	5	0	1
L:L:V11	W:W:?1	5.49	1	No	Yes	0	0	0	1
L:L:S12	R:R:Y205	5.09	0	No	Yes	0	3	0	1
L:L:S12	R:R:T298	9.59	0	No	No	0	5	0	1
L:L:S13	R:R:R299	6.59	0	No	No	0	4	0	1
L:L:Y14	R:R:P137	11.13	0	No	Yes	0	3	0	1
L:L:Y14	R:R:E138	10.1	0	No	No	0	2	0	1
L:L:L15	R:R:Y205	7.03	0	No	Yes	0	3	0	1
L:L:L15	W:W:?1	12.24	0	No	Yes	0	0	0	1
L:L:E16	R:R:L32	3.98	0	Yes	No	0	4	0	1
L:L:E16	R:R:Y205	7.86	0	Yes	Yes	0	3	0	1
L:L:E16	R:R:R299	11.63	0	Yes	No	0	4	0	1
L:L:K21	R:R:E128	17.55	0	No	No	0	3	0	1
L:L:E22	R:R:A209	4.53	0	No	No	0	1	0	1
L:L:F23	R:R:V36	3.93	2	Yes	No	0	2	0	1
L:L:F23	R:R:W214	18.04	2	Yes	No	0	1	0	1
L:L:I24	R:R:L89	7.14	2	No	No	0	5	0	1
L:L:I24	R:R:W91	3.52	2	No	Yes	0	4	0	1
L:L:W26	R:R:H212	7.41	2	Yes	No	0	3	0	1
L:L:W26	R:R:W214	18.74	2	Yes	No	0	1	0	1
L:L:L27	R:R:W39	9.11	2	No	Yes	0	5	0	1
L:L:L27	R:R:Y88	3.52	2	No	Yes	0	5	0	1
L:L:V28	R:R:R121	5.23	2	No	Yes	0	6	0	1
L:L:V28	R:R:L123	4.47	2	No	No	0	5	0	1
R:R:P90	R:R:V30	3.53	0	No	No	4	2	1	2
R:R:L218	R:R:V36	4.47	0	No	No	3	2	2	1
R:R:K38	R:R:Y88	3.58	0	No	Yes	4	5	2	1
R:R:R43	R:R:W39	9	0	No	Yes	4	5	2	1
R:R:E68	R:R:W39	4.36	0	No	Yes	4	5	2	1
R:R:W39	R:R:Y88	15.43	2	Yes	Yes	5	5	1	1
R:R:P86	R:R:Y42	6.95	2	No	Yes	8	6	2	2
R:R:Y42	R:R:Y88	5.96	2	Yes	Yes	6	5	2	1
R:R:P86	R:R:Y69	5.56	2	No	Yes	8	6	2	2
R:R:Y69	R:R:Y88	4.96	2	Yes	Yes	6	5	2	1
R:R:L89	R:R:Y69	4.69	2	No	Yes	5	6	1	2
R:R:R121	R:R:Y69	5.14	2	Yes	Yes	6	6	1	2
R:R:L123	R:R:Y69	4.69	2	No	Yes	5	6	1	2
R:R:P86	R:R:Y88	5.56	2	No	Yes	8	5	2	1
R:R:L89	R:R:W91	26.19	2	No	Yes	5	4	1	1
R:R:P90	R:R:W91	8.11	0	No	Yes	4	4	1	1
R:R:S94	R:R:W91	4.94	0	No	Yes	4	4	2	1
R:R:E128	R:R:W91	8.72	0	No	Yes	3	4	1	1
R:R:P119	R:R:R121	2.88	0	No	Yes	6	6	2	1
R:R:L123	R:R:R121	9.72	2	No	Yes	5	6	1	1
R:R:P137	R:R:Q140	3.16	0	Yes	No	3	4	1	2
R:R:L141	R:R:P137	4.93	1	No	Yes	5	3	1	1
R:R:L142	W:W:?1	21.42	0	No	Yes	3	0	2	1
R:R:L144	R:R:L384	4.15	1	No	No	6	5	1	1
R:R:Y145	R:R:Y148	8.94	1	Yes	Yes	5	7	1	1
R:R:T149	R:R:Y145	13.73	0	No	Yes	7	5	2	1
R:R:D198	R:R:Y145	14.94	1	No	Yes	7	5	2	1
R:R:Y145	W:W:?1	32.83	1	Yes	Yes	5	0	1	1
R:R:Y148	R:R:Y152	3.97	1	Yes	Yes	7	7	1	1
R:R:V194	R:R:Y148	5.05	1	No	Yes	7	7	2	1
R:R:K197	R:R:Y148	4.78	1	Yes	Yes	6	7	1	1
R:R:D198	R:R:Y148	8.05	1	No	Yes	7	7	2	1
R:R:L388	R:R:Y148	9.38	1	No	Yes	7	7	1	1
R:R:R190	R:R:Y152	7.2	1	Yes	Yes	8	7	1	1
R:R:A191	R:R:Y152	4	0	No	Yes	7	7	2	1
R:R:V194	R:R:Y152	7.57	1	No	Yes	7	7	2	1
R:R:S392	R:R:Y152	7.63	1	No	Yes	9	7	2	1
R:R:R190	R:R:V237	11.77	1	Yes	No	8	6	1	1
R:R:N240	R:R:R190	13.26	0	No	Yes	9	8	2	1
R:R:R190	R:R:Y241	13.38	1	Yes	Yes	8	8	1	1
R:R:R190	R:R:T391	5.17	1	Yes	Yes	8	6	1	1
R:R:D198	R:R:K197	9.68	1	No	Yes	7	6	2	1
R:R:K197	R:R:L201	2.82	1	Yes	No	6	7	1	2
R:R:F230	R:R:K197	4.96	1	No	Yes	5	6	2	1
R:R:K197	R:R:M233	7.2	1	Yes	No	6	6	1	1
R:R:F230	R:R:L201	3.65	1	No	No	5	7	2	2
R:R:L201	W:W:?1	3.06	1	No	Yes	7	0	2	1
R:R:K202	R:R:S206	3.06	1	No	No	4	4	2	2
R:R:K202	W:W:?1	18.71	1	No	Yes	4	0	2	1
R:R:M204	R:R:Y205	8.38	3	Yes	Yes	3	3	2	1
R:R:S206	W:W:?1	8.85	1	No	Yes	4	0	2	1
R:R:Q210	R:R:T207	2.83	13	No	No	4	3	1	2
R:R:Q211	R:R:T207	5.67	13	No	No	4	3	2	2
R:R:Q210	R:R:Q211	7.68	13	No	No	4	4	1	2
R:R:H212	R:R:W214	9.52	2	No	No	3	1	1	1
R:R:F230	R:R:T298	12.97	1	No	No	5	5	2	1
R:R:Q234	R:R:W284	8.76	1	Yes	Yes	7	8	1	2
R:R:Q234	R:R:W306	7.67	1	Yes	Yes	7	6	1	1
R:R:I309	R:R:Q234	4.12	1	Yes	Yes	7	7	2	1
R:R:V237	R:R:Y241	3.79	1	No	Yes	6	8	1	1
R:R:I313	R:R:Y241	9.67	0	No	Yes	7	8	2	1
R:R:E364	R:R:Y241	10.1	1	Yes	Yes	8	8	2	1
R:R:T391	R:R:Y241	3.75	1	Yes	Yes	6	8	1	1
R:R:I309	R:R:W284	5.87	1	Yes	Yes	7	8	2	2
R:R:N300	R:R:W306	12.43	0	No	Yes	6	6	1	1
R:R:I309	R:R:W306	7.05	1	Yes	Yes	7	6	2	1
R:R:R310	R:R:W306	9	0	Yes	Yes	6	6	2	1
R:R:E373	R:R:R310	9.3	0	Yes	Yes	4	6	2	2
R:R:E364	R:R:H363	9.85	1	Yes	Yes	8	8	2	2
R:R:H363	R:R:T391	5.48	1	Yes	Yes	8	6	2	1
R:R:H363	R:R:Q394	6.18	1	Yes	Yes	8	9	2	2
R:R:E364	R:R:T391	7.06	1	Yes	Yes	8	6	2	1
R:R:D372	R:R:E373	5.2	1	No	Yes	5	4	1	2
R:R:D372	R:R:R380	10.72	1	No	Yes	5	5	1	1
R:R:Q394	R:R:T391	4.25	1	Yes	Yes	9	6	2	1
R:R:A375	R:R:R380	2.77	0	No	Yes	4	5	2	1
L:L:F23	R:R:T35	2.59	2	Yes	No	0	5	0	1
R:R:F367	R:R:K383	2.48	0	Yes	No	7	7	2	1
R:R:I146	R:R:Y145	2.42	0	No	Yes	4	5	2	1
L:L:A20	R:R:P90	1.87	0	No	No	0	4	0	1
R:R:P137	R:R:S136	1.78	0	Yes	No	3	1	1	2
L:L:A3	R:R:K383	1.61	0	No	No	0	7	0	1
L:L:A19	R:R:L32	1.58	0	No	No	0	4	0	1
L:L:E22	R:R:Q210	1.27	0	No	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:F7	L:L:V11	6.55	1	Yes	No	0	0	2	1
L:L:F7	R:R:L141	4.87	1	Yes	No	0	5	2	2
L:L:F7	R:R:Y145	3.09	1	Yes	Yes	0	5	2	1
L:L:F7	R:R:Y148	7.22	1	Yes	Yes	0	7	2	2
L:L:V11	R:R:L141	4.47	1	No	No	0	5	1	2
L:L:V11	W:W:?1	5.49	1	No	Yes	0	0	1	0
L:L:L15	R:R:Y205	7.03	0	No	Yes	0	3	1	2
L:L:L15	W:W:?1	12.24	0	No	Yes	0	0	1	0
R:R:L142	W:W:?1	21.42	0	No	Yes	3	0	1	0
R:R:Y145	R:R:Y148	8.94	1	Yes	Yes	5	7	1	2
R:R:T149	R:R:Y145	13.73	0	No	Yes	7	5	2	1
R:R:D198	R:R:Y145	14.94	1	No	Yes	7	5	2	1
R:R:Y145	W:W:?1	32.83	1	Yes	Yes	5	0	1	0
R:R:K197	R:R:Y148	4.78	1	Yes	Yes	6	7	2	2
R:R:D198	R:R:Y148	8.05	1	No	Yes	7	7	2	2
R:R:D198	R:R:K197	9.68	1	No	Yes	7	6	2	2
R:R:K197	R:R:L201	2.82	1	Yes	No	6	7	2	1
R:R:F230	R:R:K197	4.96	1	No	Yes	5	6	2	2
R:R:F230	R:R:L201	3.65	1	No	No	5	7	2	1
R:R:L201	W:W:?1	3.06	1	No	Yes	7	0	1	0
R:R:K202	R:R:S206	3.06	1	No	No	4	4	1	1
R:R:K202	W:W:?1	18.71	1	No	Yes	4	0	1	0
R:R:S206	W:W:?1	8.85	1	No	Yes	4	0	1	0
R:R:I146	R:R:Y145	2.42	0	No	Yes	4	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6VCB_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.81
Number of Linked Nodes	381
Number of Links	454
Number of Hubs	62
Number of Links mediated by Hubs	254
Number of Communities	14
Number of Nodes involved in Communities	104
Number of Links involved in Communities	144

Path Summary
Number Of Nodes in MetaPath	91
Number Of Links MetaPath	90
Number of Shortest Paths	140249
Length Of Smallest Path	3
Average Path Length	17.5157
Length of Longest Path	47
Minimum Path Strength	1.29
Average Path Strength	7.35143
Maximum Path Strength	27.125
Minimum Path Correlation	0.7
Average Path Correlation	0.961055
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	64.7458
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.5735
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • heart process • multicellular organismal process • system process • regulation of biological process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • regulation of blood pressure • positive regulation of blood pressure • cellular response to stimulus • regulation of cellular process • response to stimulus • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to stress • response to psychosocial stress • cell surface receptor signaling pathway • behavior • learning or memory • nervous system process • cognition • transport • secretion • regulation of hormone levels • cell-cell signaling • export from cell • hormone secretion • establishment of localization • localization • secretion by cell • signal release • hormone transport • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • protein localization • establishment of protein localization • cellular localization • nitrogen compound transport • protein targeting • protein transmembrane transport • cellular macromolecule localization • establishment of localization in cell • post-translational protein targeting to membrane, translocation • establishment of protein localization to endoplasmic reticulum • protein localization to endoplasmic reticulum • establishment of protein localization to membrane • intracellular protein transmembrane transport • intracellular transport • post-translational protein targeting to endoplasmic reticulum membrane • localization within membrane • protein localization to membrane • protein targeting to membrane • transmembrane transport • establishment of protein localization to organelle • protein transport • macromolecule localization • protein localization to organelle • intracellular protein transport • protein targeting to ER • negative regulation of blood pressure • cellular anatomical structure • membrane • cell periphery • plasma membrane • protein binding • binding • signaling receptor binding • molecular transducer activity • molecular function activator activity • signaling receptor activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • G protein-coupled receptor binding • glucagon receptor binding • hormone activity • identical protein binding • monosaccharide metabolic process • positive regulation of biological process • gluconeogenesis • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • small molecule metabolic process • regulation of carbohydrate metabolic process • regulation of glucose metabolic process • positive regulation of cellular process • positive regulation of gluconeogenesis • regulation of biosynthetic process • carbohydrate metabolic process • small molecule biosynthetic process • carbohydrate biosynthetic process • hexose metabolic process • primary metabolic process • monosaccharide biosynthetic process • hexose biosynthetic process • positive regulation of glucose metabolic process • biosynthetic process • regulation of gluconeogenesis • metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • glucose metabolic process • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of programmed cell death • regulation of apoptotic process • negative regulation of biological process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of cellular process • apoptotic process • programmed cell death • cellular response to nitrogen compound • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular response to hormone stimulus • response to activity • protein kinase A signaling • negative regulation of execution phase of apoptosis • regulation of execution phase of apoptosis • execution phase of apoptosis • feeding behavior • regulation of localization • regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • regulation of secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • amide transport • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • insulin secretion • positive regulation of establishment of protein localization • carbohydrate homeostasis • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • positive regulation of peptide hormone secretion • intracellular glucose homeostasis • cellular response to carbohydrate stimulus • chemical homeostasis • response to glucose • glucose homeostasis • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • homeostatic process • positive regulation of secretion by cell • positive regulation of protein transport • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • positive regulation of peptide secretion • cellular response to glucose stimulus • positive regulation of protein secretion • response to hexose • cellular homeostasis • positive regulation of transport • regulation of insulin secretion involved in cellular response to glucose stimulus • regulation of calcium ion import • regulation of calcium ion transport • positive regulation of calcium ion transport • positive regulation of calcium ion import • regulation of monoatomic ion transport • calcium ion transport • metal ion transport • positive regulation of monoatomic ion transport • monoatomic ion transport • calcium ion import • monoatomic cation transport • regulation of metal ion transport • membrane-bounded organelle • intracellular anatomical structure • membrane-enclosed lumen • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle lumen • endoplasmic reticulum lumen • intracellular organelle • organelle lumen • organelle • endoplasmic reticulum • cytoplasm • extracellular region • vesicle lumen • intracellular vesicle • cytoplasmic vesicle lumen • secretory granule lumen • cytoplasmic vesicle • secretory granule • secretory vesicle • vesicle • extracellular space • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of chemical stimulus • sensory perception • sensory perception of smell • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • organelle membrane • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• FnI-like domain • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• FnI-like domain • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	QW7
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	QW7
Name	1-[(1R)-1-(2,6-dichloro-3-methoxyphenyl)ethyl]-6-{2-[(2R)-piperidin-2-yl]phenyl}-1H-benzimidazole
Synonyms
Identifier
Formula	C27 H27 Cl2 N3 O
Molecular Weight	480.429
SMILES
PubChem	146155955
Formal Charge	0
Total Atoms	60
Total Chiral Atoms	2
Total Bonds	64
Total Aromatic Bonds	22


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43220
Sequence	>6VCB_nogp_Chain_R T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S P E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F R H L H C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S T A A Q Q H Q W D G L L S Y Q D S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S V F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E D E G C W T R N S N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L D I K C R L A K S T L T L I P L L G T H E V I F A F V M D E H A R G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E V Q L E F R K S W E R W R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9IVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839	chim(NtGi1-Gs)/β2/γ2	3.22	2024-11-13	10.1016/j.apsb.2024.09.002
	9IVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839		3.22	2024-11-13	10.1016/j.apsb.2024.09.002
	8YW3	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8WG7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.54	2024-03-06	10.1038/s41421-024-00649-0
	8WG7 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.54	2024-03-06	10.1038/s41421-024-00649-0
	8JIS	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-	chim(NtGi1-Gs)/β1/γ2	2.46	2023-11-08	10.1073/pnas.2303696120
	8JIS (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-		2.46	2023-11-08	10.1073/pnas.2303696120
	8JIR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-	chim(NtGi1-Gs)/β1/γ2	2.57	2023-09-06	10.1073/pnas.2303696120
	8JIR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-		2.57	2023-09-06	10.1073/pnas.2303696120
	8JIP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-	chim(NtGi1-Gs)/β1/γ2	2.85	2023-09-06	10.1073/pnas.2303696120
	8JIP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-		2.85	2023-09-06	10.1073/pnas.2303696120
	9IVG	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	chim(NtGi1-Gs)/β1/γ2	3	2024-11-27	10.1016/j.apsb.2024.09.002
	9IVG (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-		3	2024-11-27	10.1016/j.apsb.2024.09.002
	9J1P	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-	chim(NtGi1-Gs)/β1/γ2	2.99	2025-02-26	10.1021/jacs.4c12808
	9J1P (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-		2.99	2025-02-26	10.1021/jacs.4c12808
	7X8S	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-	Gs/β1/γ2	3.09	2022-06-29	10.1073/pnas.2200155119
	7X8S (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-		3.09	2022-06-29	10.1073/pnas.2200155119
	7X8R	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-	Gs/β1/γ2	2.61	2022-06-29	10.1073/pnas.2200155119
	7X8R (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-		2.61	2022-06-29	10.1073/pnas.2200155119
	7S15	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 134611223	-	-	3.8	2022-06-08	10.1021/acs.jmedchem.1c01856
	7RGP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2022-04-13	10.1073/pnas.2116506119
	7RGP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		2.9	2022-04-13	10.1073/pnas.2116506119
	7RG9	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-04-13	10.1073/pnas.2116506119
	7RG9 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.2	2022-04-13	10.1073/pnas.2116506119
	7VBH	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3	2022-04-06	10.1038/s41467-022-28683-0
	7VBH (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-		3	2022-04-06	10.1038/s41467-022-28683-0
	7VBI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-	Gs/β1/γ2	3	2022-03-02	10.1038/s41467-022-28683-0
	7VBI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-		3	2022-03-02	10.1038/s41467-022-28683-0
	7FIM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	10.1038/s41467-022-28683-0
	7FIM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	10.1038/s41467-022-28683-0
	7LLY	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-	Gs/β1/γ2	3.3	2022-01-12	10.1038/s41467-021-27760-0
	7LLY (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-		3.3	2022-01-12	10.1038/s41467-021-27760-0
	7LLL	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	3.7	2022-01-12	10.1038/s41467-021-27760-0
	7LLL (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		3.7	2022-01-12	10.1038/s41467-021-27760-0
	7S3I	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.51	2022-01-05	10.1038/s41589-021-00945-w
	7S3I (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.51	2022-01-05	10.1038/s41589-021-00945-w
	7S1M	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-	Gs/β1/γ2	2.41	2022-01-05	10.1038/s41589-021-00945-w
	7S1M (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-		2.41	2022-01-05	10.1038/s41589-021-00945-w
	7RTB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-	Gs/β1/γ2	2.14	2021-10-06	10.1016/j.bbrc.2021.09.016
	7RTB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-		2.14	2021-10-06	10.1016/j.bbrc.2021.09.016
	7EVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	2.5	2021-08-11	10.1038/s41467-021-24058-z
	7EVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		2.5	2021-08-11	10.1038/s41467-021-24058-z
	7DUR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	3.3	2021-08-11	10.1038/s41467-021-24058-z
	7DUR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		3.3	2021-08-11	10.1038/s41467-021-24058-z
	7KI1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-	Gs/β1/γ2	2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI1 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-		2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI0	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-	Gs/β1/γ2	2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI0 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-		2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7DUQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738	Gs/β1/γ2	2.5	2021-07-14	10.1038/s41467-021-24058-z
	7DUQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738		2.5	2021-07-14	10.1038/s41467-021-24058-z
	7E14	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738	Gs/β1/γ2	2.9	2021-07-07	10.1038/s41467-021-24058-z
	7E14 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738		2.9	2021-07-07	10.1038/s41467-021-24058-z
	7LCK	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	3.24	2021-01-20	10.1016/j.str.2021.04.008
	7LCJ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	2.82	2021-01-20	10.1016/j.str.2021.04.008
	7LCI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.9	2021-01-20	10.1016/j.str.2021.04.008
	7LCI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.9	2021-01-20	10.1016/j.str.2021.04.008
	6XOX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-	chim(NtGi1-Gs)/β1/γ2	3.1	2020-11-18	10.1073/pnas.2014879117
	6XOX (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-		3.1	2020-11-18	10.1073/pnas.2014879117
	6X1A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.5	2020-09-09	10.1016/j.molcel.2020.09.020
	6X1A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.5	2020-09-09	10.1016/j.molcel.2020.09.020
	6X19	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-	Gs/β1/γ2	2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X19 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-		2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X18	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X18 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	7C2E	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-	Gs/β1/γ2	4.2	2020-08-26	10.1038/s41422-020-0384-8
	7C2E (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-		4.2	2020-08-26	10.1038/s41422-020-0384-8
	6VCB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440	Gs/β1/γ2	3.3	2020-07-22	10.1038/s41589-020-0589-7
	6VCB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440		3.3	2020-07-22	10.1038/s41589-020-0589-7
	6LN2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	3.2	2020-03-18	10.1038/s41467-020-14934-5
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	10.1038/s41586-019-1902-z
	6KK7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	3.1	2019-11-13	10.1107/S2052252519013496
	6KK1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	2.8	2019-11-13	10.1107/S2052252519013496
	6KJV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	2.8	2019-11-13	10.1107/S2052252519013496
	6B3J	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-	Gs/β1/γ2	3.3	2018-02-21	10.1038/nature25773
	6B3J (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-		3.3	2018-02-21	10.1038/nature25773
	5NX2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	-	3.7	2017-06-14	10.1038/nature22800
	5VEW	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.7	2017-05-24	10.1038/nature22378
	5VAI	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-	Gs/β1/γ2	4.1	2017-05-24	10.1038/nature22394
	5VAI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-		4.1	2017-05-24	10.1038/nature22394
	5VEX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	NNC0640	-	3	2017-05-17	10.1038/nature22378

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6VCB_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.