psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?2	R:R:S31	4.38	Yes	Yes	2	0	4
2	L:L:?2	R:R:L32	8.07	Yes	No	0	0	4
3	L:L:?2	R:R:W33	11.95	Yes	Yes	2	0	3
4	L:L:?2	R:R:V36	5.21	Yes	No	0	0	2
5	L:L:?2	R:R:K197	9.87	Yes	Yes	0	0	6
6	L:L:?2	R:R:L201	4.84	Yes	No	0	0	7
7	L:L:?2	R:R:W203	17.93	Yes	Yes	2	0	3
8	L:L:?2	R:R:L217	12.11	Yes	No	0	0	4
9	L:L:?2	R:R:Q221	10.09	Yes	No	2	0	4
10	L:L:?2	R:R:F230	13.49	Yes	No	0	0	5
11	L:L:?2	R:R:C296	5.55	Yes	No	2	0	9
12	L:L:?2	R:R:R380	7.79	Yes	No	2	0	5
13	L:L:?2	R:R:F381	14.2	Yes	No	2	0	4
14	L:L:?2	R:R:L384	4.04	Yes	No	2	0	5
15	R:R:T29	R:R:V30	3.17	No	No	0	2	2
16	R:R:P137	R:R:S31	3.56	No	Yes	2	3	4
17	R:R:E138	R:R:S31	7.19	No	Yes	0	2	4
18	R:R:S31	R:R:T378	9.59	Yes	No	2	4	2
19	R:R:L32	R:R:W214	3.42	No	Yes	0	4	1
20	R:R:E34	R:R:W33	4.36	Yes	Yes	0	4	3
21	R:R:Q37	R:R:W33	12.05	No	Yes	0	4	3
22	R:R:Q221	R:R:W33	6.57	No	Yes	2	4	3
23	R:R:F381	R:R:W33	16.04	No	Yes	2	4	3
24	R:R:E34	R:R:G377	3.27	Yes	No	0	4	4
25	R:R:E34	R:R:T378	8.47	Yes	No	0	4	2
26	R:R:P90	R:R:T35	8.74	No	No	0	4	5
27	R:R:T35	R:R:W214	3.64	No	Yes	0	5	1
28	R:R:V36	R:R:W214	8.58	No	Yes	0	2	1
29	R:R:L218	R:R:V36	4.47	No	No	0	3	2
30	R:R:L218	R:R:Q37	3.99	No	No	0	3	4
31	R:R:R43	R:R:W39	10	No	Yes	1	4	5
32	R:R:F66	R:R:W39	5.01	Yes	Yes	1	7	5
33	R:R:E68	R:R:W39	7.63	No	Yes	1	4	5
34	R:R:W39	R:R:Y88	18.33	Yes	Yes	1	5	5
35	R:R:W214	R:R:W39	11.25	Yes	Yes	1	1	5
36	R:R:L218	R:R:R40	12.15	No	No	0	3	2
37	R:R:D222	R:R:R40	9.53	No	No	5	6	2
38	R:R:E294	R:R:R40	11.63	Yes	No	5	4	2
39	R:R:E41	R:R:Q45	12.74	No	No	0	4	5
40	R:R:E41	R:R:W87	5.45	No	No	0	4	3
41	R:R:C46	R:R:Y42	5.38	No	Yes	1	8	6
42	R:R:C71	R:R:Y42	5.38	No	Yes	1	9	6
43	R:R:P86	R:R:Y42	9.74	No	Yes	1	8	6
44	R:R:W87	R:R:Y42	14.47	No	Yes	0	3	6
45	R:R:Y42	R:R:Y88	9.93	Yes	Yes	1	6	5
46	R:R:F66	R:R:R43	6.41	Yes	No	1	7	4
47	R:R:D215	R:R:R43	3.57	No	No	0	3	4
48	R:R:E294	R:R:R44	3.49	Yes	No	0	4	3
49	R:R:Q45	R:R:R48	5.84	No	No	0	5	4
50	R:R:C46	R:R:C71	7.28	No	No	1	8	9
51	R:R:E52	R:R:R48	5.82	No	No	0	2	4
52	R:R:D53	R:R:S49	7.36	No	No	0	3	2
53	R:R:L50	R:R:R64	4.86	No	No	0	4	4
54	R:R:D53	R:R:P54	4.83	No	No	0	3	2
55	R:R:D53	R:R:R64	4.76	No	No	0	3	4
56	R:R:F61	R:R:P56	4.33	Yes	No	0	3	1
57	R:R:F61	R:R:N63	7.25	Yes	No	0	3	4
58	R:R:D74	R:R:F61	4.78	No	Yes	0	3	3
59	R:R:C104	R:R:C62	7.28	No	No	1	9	9
60	R:R:C62	R:R:W110	11.75	No	Yes	1	9	9
61	R:R:D74	R:R:R64	20.25	No	No	0	3	4
62	R:R:E68	R:R:F66	4.66	No	Yes	1	4	7
63	R:R:D67	R:R:W72	7.82	No	Yes	1	9	9
64	R:R:D67	R:R:L118	5.43	No	Yes	1	9	4
65	R:R:D67	R:R:R121	9.53	No	Yes	1	9	6
66	R:R:D215	R:R:E68	6.5	No	No	0	3	4
67	R:R:Y69	R:R:Y88	3.97	Yes	Yes	1	6	5
68	R:R:V100	R:R:Y69	3.79	No	Yes	1	7	6
69	R:R:R121	R:R:Y69	7.2	Yes	Yes	1	6	6
70	R:R:L123	R:R:Y69	9.38	No	Yes	1	5	6
71	R:R:Q211	R:R:Y69	5.64	No	Yes	1	4	6
72	R:R:A70	R:R:W72	7.78	No	Yes	0	5	9
73	R:R:V83	R:R:W72	7.36	No	Yes	1	5	9
74	R:R:V100	R:R:W72	7.36	No	Yes	1	7	9
75	R:R:R102	R:R:W72	25.99	Yes	Yes	1	8	9
76	R:R:E76	R:R:P77	4.72	No	No	0	1	4
77	R:R:F80	R:R:Y101	5.16	No	Yes	0	4	5
78	R:R:F103	R:R:F80	10.72	No	No	0	4	4
79	R:R:F80	R:R:W120	4.01	No	No	0	4	5
80	R:R:V81	R:R:W110	3.68	No	Yes	0	6	9
81	R:R:N82	R:R:Y101	5.81	No	Yes	0	4	5
82	R:R:V100	R:R:V83	3.21	No	No	1	7	5
83	R:R:C126	R:R:C85	7.28	No	No	1	9	9
84	R:R:P86	R:R:Y88	8.34	No	Yes	1	8	5
85	R:R:L89	R:R:Y88	8.21	No	Yes	0	5	5
86	R:R:Q211	R:R:Y88	5.64	No	Yes	1	4	5
87	R:R:W214	R:R:Y88	4.82	Yes	Yes	1	1	5
88	R:R:L89	R:R:W91	18.22	No	No	0	5	4
89	R:R:P90	R:R:W91	8.11	No	No	0	4	4
90	R:R:E128	R:R:W91	17.45	No	No	0	3	4
91	R:R:C126	R:R:V95	6.83	No	No	0	9	5
92	R:R:P96	R:R:Q97	4.74	No	No	0	3	4
93	R:R:E125	R:R:G98	3.27	No	Yes	0	5	4
94	R:R:H99	R:R:Y101	4.36	No	Yes	0	4	5
95	R:R:E125	R:R:Y101	3.37	No	Yes	0	5	5
96	R:R:R102	R:R:W110	21.99	Yes	Yes	1	8	9
97	R:R:P119	R:R:R102	11.53	Yes	Yes	1	6	8
98	R:R:C104	R:R:W110	5.22	No	Yes	1	9	9
99	R:R:E107	R:R:T105	12.7	No	No	0	5	4
100	R:R:E107	R:R:L109	6.63	No	No	0	5	5
101	R:R:P119	R:R:W110	5.4	Yes	Yes	1	6	9
102	R:R:L111	R:R:W120	6.83	No	No	0	4	5
103	R:R:P119	R:R:Q112	6.32	Yes	No	0	6	3
104	R:R:L118	R:R:P119	3.28	Yes	Yes	1	4	6
105	R:R:L118	R:R:R121	7.29	Yes	Yes	1	4	6
106	R:R:D122	R:R:W120	4.47	No	No	0	7	5
107	R:R:L123	R:R:R121	6.07	No	Yes	1	5	6
108	R:R:E127	R:R:S124	7.19	No	No	0	2	5
109	R:R:E128	R:R:R131	10.47	No	No	0	3	2
110	R:R:R131	R:R:R134	4.26	No	No	0	2	1
111	R:R:E139	R:R:S135	4.31	No	No	0	2	1
112	R:R:P137	R:R:S136	5.34	No	No	0	3	1
113	R:R:P137	R:R:T378	3.5	No	No	2	3	2
114	R:R:E138	R:R:T207	5.64	No	No	0	2	3
115	R:R:I382	R:R:Q140	8.23	No	No	0	4	4
116	R:R:I382	R:R:L141	5.71	No	No	0	4	5
117	R:R:F385	R:R:L141	6.09	No	No	0	6	5
118	R:R:L142	R:R:W203	4.56	No	Yes	0	3	3
119	R:R:L142	R:R:T207	5.9	No	No	0	3	3
120	R:R:F143	R:R:I147	7.54	No	No	0	4	6
121	R:R:F385	R:R:L144	4.87	No	No	0	6	6
122	R:R:Y145	R:R:Y148	4.96	Yes	Yes	2	5	7
123	R:R:T149	R:R:Y145	12.48	No	Yes	0	7	5
124	R:R:D198	R:R:Y145	12.64	Yes	Yes	2	7	5
125	R:R:W203	R:R:Y145	7.72	Yes	Yes	2	3	5
126	R:R:M204	R:R:Y145	17.96	No	Yes	2	3	5
127	R:R:I147	R:R:S389	9.29	No	No	0	6	5
128	R:R:V194	R:R:Y148	3.79	No	Yes	0	7	7
129	R:R:D198	R:R:Y148	9.2	Yes	Yes	2	7	7
130	R:R:F385	R:R:Y148	11.35	No	Yes	0	6	7
131	R:R:L388	R:R:Y148	3.52	No	Yes	0	7	7
132	R:R:G151	R:R:S392	3.71	No	No	6	8	9
133	R:R:F393	R:R:G151	4.52	No	No	6	7	8
134	R:R:R190	R:R:Y152	3.09	Yes	Yes	0	8	7
135	R:R:A191	R:R:Y152	5.34	No	Yes	0	7	7
136	R:R:V194	R:R:Y152	7.57	No	Yes	0	7	7
137	R:R:F195	R:R:Y152	3.09	No	Yes	0	7	7
138	R:R:L388	R:R:Y152	4.69	No	Yes	0	7	7
139	R:R:S392	R:R:Y152	5.09	No	Yes	0	9	7
140	R:R:G395	R:R:S155	3.71	No	No	0	9	9
141	R:R:F156	R:R:V160	3.93	No	No	0	7	3
142	R:R:F156	R:R:I188	5.02	No	No	0	7	7
143	R:R:F184	R:R:L159	6.09	Yes	Yes	0	8	9
144	R:R:F187	R:R:L159	3.65	Yes	Yes	0	8	9
145	R:R:I188	R:R:L159	4.28	No	Yes	0	7	9
146	R:R:G395	R:R:L159	3.42	No	Yes	0	9	9
147	R:R:A399	R:R:L159	3.15	No	Yes	0	8	9
148	R:R:F404	R:R:I161	5.02	Yes	No	0	8	4
149	R:R:A162	R:R:C403	3.61	No	No	4	9	9
150	R:R:A162	R:R:F404	4.16	No	Yes	4	9	8
151	R:R:F184	R:R:S163	3.96	Yes	No	0	8	6
152	R:R:C403	R:R:I165	4.91	No	No	4	9	8
153	R:R:I165	R:R:V409	3.07	No	No	4	8	9
154	R:R:F413	R:R:I165	5.02	No	No	4	5	8
155	R:R:L166	R:R:N177	8.24	Yes	No	0	8	9
156	R:R:L166	R:R:L181	5.54	Yes	No	0	8	6
157	R:R:F184	R:R:L166	3.65	Yes	Yes	0	8	8
158	R:R:L167	R:R:L181	4.15	No	No	0	3	6
159	R:R:F169	R:R:L172	4.87	Yes	No	0	7	9
160	R:R:E412	R:R:F169	10.49	No	Yes	0	8	7
161	R:R:F169	R:R:F413	5.36	Yes	No	0	7	5
162	R:R:F169	R:R:S416	3.96	Yes	No	0	7	5
163	R:R:E412	R:R:H171	8.62	No	No	0	8	7
164	R:R:E408	R:R:L172	5.3	No	No	0	9	9
165	R:R:H173	R:R:Y178	9.8	No	No	0	7	6
166	R:R:C174	R:R:N177	4.72	No	No	0	8	9
167	R:R:T175	R:R:Y250	6.24	No	Yes	0	7	8
168	R:R:H180	R:R:R176	3.39	Yes	No	0	9	9
169	R:R:F266	R:R:Y178	5.16	No	No	0	6	6
170	R:R:E247	R:R:I179	8.2	Yes	No	0	9	8
171	R:R:I179	R:R:Y250	8.46	No	Yes	0	8	8
172	R:R:F184	R:R:H180	3.39	Yes	Yes	0	8	9
173	R:R:E247	R:R:H180	12.31	Yes	Yes	3	9	9
174	R:R:H180	R:R:L359	3.86	Yes	No	3	9	9
175	R:R:H180	R:R:Y402	5.44	Yes	No	3	9	8
176	R:R:N182	R:R:W243	15.82	No	Yes	8	9	9
177	R:R:N182	R:R:W274	5.65	No	Yes	8	9	9
178	R:R:F187	R:R:L183	7.31	Yes	No	3	8	9
179	R:R:L183	R:R:L244	5.54	No	No	3	9	9
180	R:R:E247	R:R:L183	7.95	Yes	No	3	9	9
181	R:R:F184	R:R:V398	3.93	Yes	No	0	8	9
182	R:R:N240	R:R:S186	7.45	No	No	0	9	9
183	R:R:S186	R:R:W243	4.94	No	Yes	0	9	9
184	R:R:F187	R:R:N240	16.92	Yes	No	0	8	9
185	R:R:F187	R:R:L244	3.65	Yes	No	3	8	9
186	R:R:F187	R:R:Q394	9.37	Yes	No	3	8	9
187	R:R:F187	R:R:V398	5.24	Yes	No	0	8	9
188	R:R:R190	R:R:V237	14.38	Yes	No	3	8	6
189	R:R:N240	R:R:R190	10.85	No	Yes	0	9	8
190	R:R:R190	R:R:Y241	12.35	Yes	Yes	3	8	8
191	R:R:I196	R:R:L192	5.71	No	No	0	5	3
192	R:R:M233	R:R:S193	6.13	No	No	0	6	6
193	R:R:C236	R:R:S193	6.89	No	No	0	5	6
194	R:R:D198	R:R:K197	8.3	Yes	Yes	0	7	6
195	R:R:K197	R:R:M233	8.64	Yes	No	0	6	6
196	R:R:D198	R:R:W203	6.7	Yes	Yes	2	7	3
197	R:R:L201	R:R:Y220	7.03	No	Yes	0	7	3
198	R:R:K202	R:R:Y205	4.78	No	No	0	4	3
199	R:R:M204	R:R:W203	6.98	No	Yes	2	3	3
200	R:R:L217	R:R:S206	4.5	No	No	0	4	4
201	R:R:A209	R:R:Q213	7.58	No	No	0	1	4
202	R:R:H212	R:R:Q210	4.95	No	No	0	3	4
203	R:R:Q211	R:R:W214	14.24	No	Yes	1	4	1
204	R:R:H212	R:R:Q213	11.13	No	No	0	3	4
205	R:R:S223	R:R:Y220	3.82	No	Yes	9	4	3
206	R:R:S225	R:R:Y220	5.09	No	Yes	9	3	3
207	R:R:C226	R:R:Y220	8.06	No	Yes	0	9	3
208	R:R:C296	R:R:Q221	6.1	No	No	2	9	4
209	R:R:D222	R:R:E294	5.2	No	Yes	5	6	4
210	R:R:S223	R:R:S225	4.89	No	No	9	4	3
211	R:R:L224	R:R:L228	4.15	No	No	0	3	4
212	R:R:C226	R:R:C296	7.28	No	No	0	9	9
213	R:R:R227	R:R:W297	22.99	No	Yes	0	8	8
214	R:R:F230	R:R:Q234	16.4	No	No	0	5	7
215	R:R:L231	R:R:W297	6.83	No	Yes	0	5	8
216	R:R:C236	R:R:L232	3.17	No	No	0	5	5
217	R:R:L278	R:R:Y235	7.03	No	No	0	3	9
218	R:R:V237	R:R:Y241	3.79	No	Yes	3	6	8
219	R:R:A238	R:R:P277	3.74	No	Yes	0	6	9
220	R:R:I313	R:R:Y241	9.67	No	Yes	0	7	8
221	R:R:I317	R:R:Y241	3.63	No	Yes	0	7	8
222	R:R:E364	R:R:Y241	15.71	Yes	Yes	3	8	8
223	R:R:V276	R:R:Y242	7.57	No	Yes	11	3	6
224	R:R:P277	R:R:Y242	6.95	Yes	Yes	11	9	6
225	R:R:F280	R:R:Y242	7.22	No	Yes	0	5	6
226	R:R:A316	R:R:Y242	5.34	No	Yes	0	7	6
227	R:R:V246	R:R:W243	8.58	No	Yes	0	8	9
228	R:R:G273	R:R:W243	8.44	No	Yes	0	9	9
229	R:R:W243	R:R:W274	25.3	Yes	Yes	8	9	9
230	R:R:E364	R:R:L244	3.98	Yes	No	3	8	9
231	R:R:A316	R:R:L245	3.15	No	No	0	7	8
232	R:R:V246	R:R:Y269	3.79	No	Yes	0	8	7
233	R:R:I272	R:R:V246	3.07	Yes	No	0	6	8
234	R:R:E247	R:R:L359	14.58	Yes	No	3	9	9
235	R:R:G248	R:R:I323	3.53	No	Yes	0	8	8
236	R:R:V249	R:R:Y269	3.79	No	Yes	0	6	7
237	R:R:I323	R:R:V249	3.07	Yes	No	0	8	6
238	R:R:T253	R:R:Y250	3.75	No	Yes	7	7	8
239	R:R:L254	R:R:Y250	15.24	No	Yes	0	8	8
240	R:R:Y250	R:R:Y269	4.96	Yes	Yes	7	8	7
241	R:R:L251	R:R:L255	6.92	No	No	0	9	8
242	R:R:R326	R:R:Y252	6.17	No	No	0	8	8
243	R:R:T253	R:R:Y269	4.99	No	Yes	7	7	7
244	R:R:L255	R:R:V327	4.47	No	No	0	8	9
245	R:R:F260	R:R:I265	7.54	No	No	0	7	5
246	R:R:I265	R:R:W264	3.52	No	No	0	5	5
247	R:R:I265	R:R:Y269	6.04	No	Yes	0	5	7
248	R:R:F266	R:R:V270	3.93	No	No	0	6	5
249	R:R:G273	R:R:I272	3.53	No	Yes	0	9	6
250	R:R:I272	R:R:V276	3.07	Yes	No	0	6	3
251	R:R:G275	R:R:L278	5.13	No	No	0	6	3
252	R:R:P277	R:R:V276	3.53	Yes	No	11	9	3
253	R:R:F280	R:R:P312	23.12	No	No	0	5	8
254	R:R:I309	R:R:V281	4.61	No	No	0	7	6
255	R:R:P283	R:R:V282	5.3	No	No	0	5	3
256	R:R:G285	R:R:W284	5.63	No	Yes	0	5	8
257	R:R:K288	R:R:W284	16.24	No	Yes	10	8	8
258	R:R:W284	R:R:W297	5.62	Yes	Yes	10	8	8
259	R:R:I308	R:R:W284	4.7	No	Yes	0	8	8
260	R:R:I309	R:R:W284	14.09	No	Yes	0	7	8
261	R:R:V287	R:R:Y305	3.79	No	Yes	0	4	4
262	R:R:E292	R:R:K288	5.4	No	No	0	6	8
263	R:R:K288	R:R:W297	9.28	No	Yes	10	8	8
264	R:R:L290	R:R:Y291	8.21	No	No	0	3	3
265	R:R:Y291	R:R:Y305	5.96	No	Yes	0	3	4
266	R:R:E292	R:R:N300	7.89	No	No	0	6	6
267	R:R:D293	R:R:E294	3.9	No	Yes	0	7	4
268	R:R:R299	R:R:W306	20.99	Yes	Yes	2	4	6
269	R:R:R299	R:R:R310	3.2	Yes	Yes	2	4	6
270	R:R:E373	R:R:R299	11.63	No	Yes	2	4	4
271	R:R:R299	R:R:R376	4.26	Yes	No	0	4	5
272	R:R:R299	R:R:R380	22.39	Yes	No	2	4	5
273	R:R:N300	R:R:Y305	3.49	No	Yes	0	6	4
274	R:R:M303	R:R:Y305	11.97	No	Yes	0	5	4
275	R:R:L307	R:R:N304	5.49	No	No	0	7	3
276	R:R:L307	R:R:W306	10.25	No	Yes	0	7	6
277	R:R:R310	R:R:W306	4	Yes	Yes	2	6	6
278	R:R:E373	R:R:W306	11.99	No	Yes	2	4	6
279	R:R:L307	R:R:L311	6.92	No	No	0	7	4
280	R:R:L314	R:R:R310	9.72	No	Yes	0	4	6
281	R:R:E373	R:R:R310	17.45	No	Yes	2	4	6
282	R:R:L311	R:R:P312	3.28	No	No	0	4	8
283	R:R:F315	R:R:V319	3.93	No	No	0	4	6
284	R:R:I323	R:R:N320	4.25	Yes	No	0	8	9
285	R:R:L360	R:R:N320	8.24	No	No	0	9	9
286	R:R:F321	R:R:V325	3.93	Yes	No	0	6	5
287	R:R:F324	R:R:I328	7.54	Yes	No	0	9	7
288	R:R:F324	R:R:L356	7.31	Yes	No	12	9	9
289	R:R:F324	R:R:L360	3.65	Yes	No	12	9	9
290	R:R:F324	R:R:T362	6.49	Yes	No	0	9	7
291	R:R:S352	R:R:V331	3.23	No	No	0	9	8
292	R:R:L349	R:R:V332	4.47	No	No	0	9	6
293	R:R:K334	R:R:S333	4.59	No	No	0	9	7
294	R:R:I345	R:R:L335	5.71	No	No	0	5	8
295	R:R:D344	R:R:M340	9.7	No	No	0	7	5
296	R:R:I345	R:R:M340	7.29	No	No	0	5	5
297	R:R:K346	R:R:T343	9.01	No	No	0	6	5
298	R:R:K351	R:R:R348	8.66	No	No	0	8	8
299	R:R:L401	R:R:T355	4.42	No	No	0	8	8
300	R:R:L356	R:R:L360	4.15	No	No	12	9	9
301	R:R:I357	R:R:P358	3.39	No	No	0	8	9
302	R:R:I357	R:R:T362	7.6	No	No	0	8	7
303	R:R:M397	R:R:P358	3.35	No	No	0	5	9
304	R:R:L401	R:R:P358	3.28	No	No	0	8	9
305	R:R:L359	R:R:Y402	17.58	No	No	3	9	8
306	R:R:G361	R:R:H363	3.18	No	Yes	0	9	8
307	R:R:E364	R:R:H363	9.85	Yes	Yes	3	8	8
308	R:R:F367	R:R:H363	6.79	Yes	Yes	3	7	8
309	R:R:H363	R:R:T391	4.11	Yes	No	3	8	6
310	R:R:H363	R:R:Q394	13.6	Yes	No	3	8	9
311	R:R:E364	R:R:Q394	3.82	Yes	No	3	8	9
312	R:R:E387	R:R:F367	10.49	No	Yes	0	8	7
313	R:R:F367	R:R:F390	4.29	Yes	No	0	7	6
314	R:R:F367	R:R:T391	3.89	Yes	No	3	7	6
315	R:R:K383	R:R:M371	4.32	No	No	0	7	7
316	R:R:E387	R:R:M371	6.77	No	No	0	8	7
317	R:R:A375	R:R:D372	4.63	No	No	0	4	5
318	R:R:A375	R:R:L379	4.73	No	No	0	4	3
319	R:R:K383	R:R:L379	7.05	No	No	0	7	3
320	R:R:L384	R:R:R380	9.72	No	No	2	5	5
321	R:R:F393	R:R:S392	3.96	No	No	6	7	9
322	R:R:I400	R:R:L396	5.71	No	No	0	6	7
323	R:R:C403	R:R:F404	5.59	No	Yes	4	9	8
324	R:R:E408	R:R:N406	5.26	No	No	0	9	9
325	R:R:N406	R:R:V409	5.91	No	No	0	9	9
326	R:R:F413	R:R:V409	3.93	No	No	4	5	9
327	R:R:Q410	R:R:R414	5.84	No	No	0	7	6
328	R:R:K415	R:R:L411	7.05	No	No	0	7	4
329	R:R:W417	R:R:W420	9.37	No	No	0	5	4
330	R:R:E418	R:R:R421	3.49	No	No	0	4	4
331	R:R:E423	R:R:W420	3.27	No	No	0	4	4
332	R:R:K197	R:R:V229	3.04	Yes	No	0	6	7
333	R:R:F103	R:R:G78	3.01	No	No	0	4	7
334	R:R:F230	R:R:W284	3.01	No	Yes	0	5	8
335	R:R:L144	R:R:S389	3	No	No	0	6	5
336	R:R:L245	R:R:V319	2.98	No	No	0	8	6
337	R:R:L356	R:R:V327	2.98	No	No	0	9	9
338	R:R:L335	R:R:V331	2.98	No	No	0	8	8
339	R:R:L144	R:R:T386	2.95	No	No	0	6	4
340	R:R:I330	R:R:K334	2.91	No	No	0	9	9
341	R:R:K202	R:R:M204	2.88	No	No	0	4	3
342	R:R:E76	R:R:S79	2.87	No	No	0	1	5
343	R:R:E34	R:R:V30	2.85	Yes	No	0	4	2
344	R:R:I330	R:R:L255	2.85	No	No	0	9	8
345	R:R:I286	R:R:L290	2.85	No	No	0	4	3
346	R:R:P277	R:R:Y235	2.78	Yes	No	0	9	9
347	R:R:L154	R:R:L396	2.77	No	No	0	5	7
348	R:R:A158	R:R:F404	2.77	No	Yes	0	7	8
349	R:R:L166	R:R:L172	2.77	Yes	No	0	8	9
350	R:R:L335	R:R:L349	2.77	No	No	0	8	9
351	R:R:A239	R:R:Y235	2.67	No	No	0	8	9
352	R:R:N407	R:R:Q410	2.64	No	No	0	6	7
353	R:R:F321	R:R:V365	2.62	Yes	No	0	6	6
354	R:R:F369	R:R:V365	2.62	No	No	0	4	6
355	R:R:R48	R:R:T51	2.59	No	No	0	4	4
356	R:R:R102	R:R:T65	2.59	Yes	No	0	8	5
357	R:R:F266	R:R:T175	2.59	No	No	0	6	7
358	R:R:A209	R:R:W214	2.59	No	Yes	0	1	1
359	R:R:F324	R:R:T353	2.59	Yes	No	0	9	9
360	L:L:?2	R:R:T298	2.58	Yes	No	0	0	5
361	R:R:L224	R:R:R227	2.43	No	No	0	3	8
362	R:R:I323	R:R:Y252	2.42	Yes	No	0	8	8
363	R:R:D59	R:R:F61	2.39	No	Yes	0	3	3
364	R:R:F66	R:R:Q47	2.34	Yes	No	0	7	3
365	R:R:L290	R:R:Y289	2.34	No	No	0	3	3
366	R:R:L189	R:R:W274	2.28	No	Yes	0	7	9
367	R:R:F321	R:R:F324	2.14	Yes	Yes	0	6	9
368	R:R:R421	R:R:W417	2	No	No	0	4	5
369	R:R:C62	R:R:G75	1.96	No	No	0	9	7
370	R:R:C85	R:R:G98	1.96	No	Yes	1	9	4
371	R:R:C126	R:R:G98	1.96	No	Yes	1	9	4
372	R:R:P54	R:R:P55	1.95	No	No	0	2	1
373	R:R:P55	R:R:P56	1.95	No	No	0	1	1
374	R:R:C85	R:R:P86	1.88	No	No	1	9	8
375	R:R:G216	R:R:S219	1.86	No	No	0	2	5
376	R:R:G151	R:R:V150	1.84	No	No	0	8	5
377	R:R:P73	R:R:V83	1.77	No	No	0	5	5
378	R:R:G108	R:R:L109	1.71	No	No	0	9	5
379	R:R:A256	R:R:S258	1.71	No	No	0	6	7
380	R:R:C329	R:R:V325	1.71	No	No	0	7	5
381	R:R:I308	R:R:P283	1.69	No	No	0	8	5
382	R:R:C347	R:R:T343	1.69	No	No	0	7	5
383	R:R:D215	R:R:G216	1.68	No	No	0	3	2
384	R:R:D222	R:R:G295	1.68	No	No	0	6	4
385	R:R:G98	R:R:Q97	1.64	Yes	No	0	4	4
386	R:R:E133	R:R:G132	1.64	No	No	0	4	1
387	R:R:S352	R:R:T353	1.6	No	No	0	9	9
388	R:R:A158	R:R:L396	1.58	No	No	0	7	7
389	R:R:A368	R:R:L314	1.58	No	No	0	6	4
390	R:R:A350	R:R:L354	1.58	No	No	0	8	8
391	R:R:A337	R:R:N338	1.56	No	No	0	7	6
392	R:R:C341	R:R:D344	1.56	No	No	0	4	7
393	R:R:I272	R:R:S271	1.55	Yes	No	0	6	3
394	R:R:I196	R:R:V229	1.54	No	No	0	5	7
395	R:R:I366	R:R:V365	1.54	No	No	0	6	6
396	R:R:I366	R:R:V370	1.54	No	No	0	6	5
397	R:R:I400	R:R:V405	1.54	No	No	0	6	6
398	R:R:F321	R:R:G318	1.51	Yes	No	0	6	4
399	R:R:L268	R:R:S271	1.5	No	No	0	2	3
400	R:R:K342	R:R:T343	1.5	No	No	0	5	5
401	R:R:K351	R:R:T355	1.5	No	No	0	8	8
402	R:R:N300	R:R:S301	1.49	No	No	0	6	3
403	R:R:L111	R:R:T105	1.47	No	No	0	4	4
404	R:R:D122	R:R:S124	1.47	No	No	0	7	5
405	R:R:Q410	R:R:V405	1.43	No	No	0	7	6
406	R:R:K113	R:R:L118	1.41	No	Yes	0	4	4
407	R:R:M303	R:R:N302	1.4	No	No	0	5	5
408	R:R:M340	R:R:N338	1.4	No	No	0	5	6
409	R:R:A153	R:R:F195	1.39	No	No	0	6	7
410	R:R:D114	R:R:K113	1.38	No	No	0	4	4
411	R:R:E412	R:R:K415	1.35	No	No	0	8	7
412	R:R:L50	R:R:Q47	1.33	No	No	0	4	3
413	R:R:A200	R:R:Y220	1.33	No	Yes	0	4	3
414	R:R:A185	R:R:W274	1.3	No	Yes	0	3	9
415	R:R:D372	R:R:H374	1.26	No	No	0	5	3
416	R:R:S261	R:R:W264	1.24	No	No	0	7	5
417	R:R:I146	R:R:Y145	1.21	No	Yes	0	4	5
418	R:R:K38	R:R:Y88	1.19	No	Yes	0	4	5
419	R:R:Q263	R:R:R267	1.17	No	No	0	5	4
420	R:R:Q263	R:R:W264	1.1	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?2	8.80667	15	2	0
2	R:R:S31	6.18	4	2	4
3	R:R:W33	10.194	5	2	3
4	R:R:E34	4.7375	4	0	4
5	R:R:W39	10.444	5	1	5
6	R:R:Y42	8.98	5	1	6
7	R:R:F61	4.6875	4	0	3
8	R:R:F66	4.605	4	1	7
9	R:R:Y69	5.996	5	1	6
10	R:R:W72	11.262	5	1	9
11	R:R:Y88	7.55375	8	1	5
12	R:R:G98	2.2075	4	1	4
13	R:R:Y101	4.675	4	0	5
14	R:R:R102	15.525	4	1	8
15	R:R:W110	9.608	5	1	9
16	R:R:L118	4.3525	4	1	4
17	R:R:P119	6.6325	4	1	6
18	R:R:R121	7.5225	4	1	6
19	R:R:Y145	9.495	6	2	5
20	R:R:Y148	6.564	5	2	7
21	R:R:Y152	4.81167	6	0	7
22	R:R:L159	4.118	5	0	9
23	R:R:L166	5.05	4	0	8
24	R:R:F169	6.17	4	0	7
25	R:R:H180	5.678	5	3	9
26	R:R:F184	4.204	5	0	8
27	R:R:F187	7.69	6	3	8
28	R:R:R190	10.1675	4	3	8
29	R:R:K197	7.4625	4	0	6
30	R:R:D198	9.21	4	2	7
31	R:R:W203	8.778	5	2	3
32	R:R:W214	6.93429	7	1	1
33	R:R:Y220	5.066	5	9	3
34	R:R:Y241	9.03	5	3	8
35	R:R:Y242	6.77	4	11	6
36	R:R:W243	12.616	5	8	9
37	R:R:E247	10.76	4	3	9
38	R:R:Y250	7.73	5	7	8
39	R:R:Y269	4.714	5	7	7
40	R:R:I272	2.805	4	0	6
41	R:R:W274	8.6325	4	8	9
42	R:R:P277	4.25	4	11	9
43	R:R:W284	8.215	6	10	8
44	R:R:E294	6.055	4	5	4
45	R:R:W297	11.18	4	10	8
46	R:R:R299	12.494	5	2	4
47	R:R:Y305	6.3025	4	0	4
48	R:R:W306	11.8075	4	2	6
49	R:R:R310	8.5925	4	2	6
50	R:R:F321	2.55	4	0	6
51	R:R:I323	3.3175	4	0	8
52	R:R:F324	4.95333	6	12	9
53	R:R:H363	7.506	5	3	8
54	R:R:E364	8.34	4	3	8
55	R:R:F367	6.365	4	3	7
56	R:R:F404	4.385	4	4	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?2	R:R:L32	44.6299	8.07	Yes	No	0	0	4
2	R:R:L32	R:R:W214	44.309	3.42	No	Yes	0	4	1
3	L:L:?2	R:R:V36	47.1053	5.21	Yes	No	0	0	2
4	R:R:V36	R:R:W214	44.5851	8.58	No	Yes	0	2	1
5	R:R:W214	R:R:W39	15.6917	11.25	Yes	Yes	1	1	5
6	R:R:W214	R:R:Y88	46.3576	4.82	Yes	Yes	1	1	5
7	R:R:P86	R:R:Y88	16.8022	8.34	No	Yes	1	8	5
8	R:R:Y69	R:R:Y88	18.9408	3.97	Yes	Yes	1	6	5
9	R:R:V100	R:R:Y69	17.3254	3.79	No	Yes	1	7	6
10	R:R:V100	R:R:W72	13.0277	7.36	No	Yes	1	7	9
11	R:R:R102	R:R:W72	10.145	25.99	Yes	Yes	1	8	9
12	R:R:Q211	R:R:W214	19.2459	14.24	No	Yes	1	4	1
13	R:R:Q211	R:R:Y69	18.5322	5.64	No	Yes	1	4	6
14	R:R:R121	R:R:Y69	17.3254	7.2	Yes	Yes	1	6	6
15	R:R:L118	R:R:R121	14.4783	7.29	Yes	Yes	1	4	6
16	R:R:L118	R:R:P119	10.1434	3.28	Yes	Yes	1	4	6
17	R:R:C85	R:R:P86	16.1324	1.88	No	No	1	9	8
18	R:R:C85	R:R:G98	13.9377	1.96	No	Yes	1	9	4
19	R:R:E125	R:R:G98	11.7591	3.27	No	Yes	0	5	4
20	R:R:E125	R:R:Y101	11.0283	3.37	No	Yes	0	5	5
21	L:L:?2	R:R:W203	69.7607	17.93	Yes	Yes	2	0	3
22	L:L:?2	R:R:K197	35.2606	9.87	Yes	Yes	0	0	6
23	R:R:D198	R:R:K197	35.4351	8.3	Yes	Yes	0	7	6
24	R:R:D198	R:R:Y148	70.2952	9.2	Yes	Yes	2	7	7
25	R:R:D198	R:R:W203	34.9677	6.7	Yes	Yes	2	7	3
26	R:R:W203	R:R:Y145	35.1403	7.72	Yes	Yes	2	3	5
27	R:R:Y145	R:R:Y148	35.5627	4.96	Yes	Yes	2	5	7
28	R:R:V194	R:R:Y148	52.1755	3.79	No	Yes	0	7	7
29	R:R:L388	R:R:Y148	52.1755	3.52	No	Yes	0	7	7
30	R:R:V194	R:R:Y152	51.9615	7.57	No	Yes	0	7	7
31	R:R:L388	R:R:Y152	51.9615	4.69	No	Yes	0	7	7
32	R:R:R190	R:R:Y152	100	3.09	Yes	Yes	0	8	7
33	R:R:N240	R:R:R190	89.2481	10.85	No	Yes	0	9	8
34	R:R:F187	R:R:N240	53.9461	16.92	Yes	No	0	8	9
35	R:R:F187	R:R:L159	24.0057	3.65	Yes	Yes	0	8	9
36	R:R:F184	R:R:L159	19.9916	6.09	Yes	Yes	0	8	9
37	R:R:F187	R:R:V398	20.3676	5.24	Yes	No	0	8	9
38	R:R:F184	R:R:V398	19.7942	3.93	Yes	No	0	8	9
39	R:R:F184	R:R:L166	34.7767	3.65	Yes	Yes	0	8	8
40	R:R:L166	R:R:L172	29.0209	2.77	Yes	No	0	8	9
41	R:R:F169	R:R:L172	24.3633	4.87	Yes	No	0	7	9
42	R:R:F169	R:R:F413	17.4576	5.36	Yes	No	0	7	5
43	R:R:F413	R:R:I165	15.1962	5.02	No	No	4	5	8
44	R:R:C403	R:R:I165	14.0407	4.91	No	No	4	9	8
45	R:R:C403	R:R:F404	11.7033	5.59	No	Yes	4	9	8
46	R:R:N240	R:R:S186	37.8598	7.45	No	No	0	9	9
47	R:R:S186	R:R:W243	37.3156	4.94	No	Yes	0	9	9
48	R:R:V246	R:R:W243	33.347	8.58	No	Yes	0	8	9
49	R:R:V246	R:R:Y269	32.7764	3.79	No	Yes	0	8	7
50	R:R:R190	R:R:Y241	10.0708	12.35	Yes	Yes	3	8	8
51	L:L:?2	R:R:F230	10.9109	13.49	Yes	No	0	0	5
52	R:R:F230	R:R:W284	10.0848	3.01	No	Yes	0	5	8
53	R:R:V249	R:R:Y269	25.4859	3.79	No	Yes	0	6	7
54	R:R:I323	R:R:V249	24.9177	3.07	Yes	No	0	8	6
55	R:R:I323	R:R:N320	22.6393	4.25	Yes	No	0	8	9
56	R:R:L360	R:R:N320	22.0684	8.24	No	No	0	9	9
57	R:R:F324	R:R:L360	17.4228	3.65	Yes	No	12	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?2	R:R:S31	4.38	2	Yes	Yes	0	4	0	1
L:L:?2	R:R:L32	8.07	2	Yes	No	0	4	0	1
L:L:?2	R:R:W33	11.95	2	Yes	Yes	0	3	0	1
L:L:?2	R:R:V36	5.21	2	Yes	No	0	2	0	1
L:L:?2	R:R:K197	9.87	2	Yes	Yes	0	6	0	1
L:L:?2	R:R:L201	4.84	2	Yes	No	0	7	0	1
L:L:?2	R:R:W203	17.93	2	Yes	Yes	0	3	0	1
L:L:?2	R:R:L217	12.11	2	Yes	No	0	4	0	1
L:L:?2	R:R:Q221	10.09	2	Yes	No	0	4	0	1
L:L:?2	R:R:F230	13.49	2	Yes	No	0	5	0	1
L:L:?2	R:R:C296	5.55	2	Yes	No	0	9	0	1
L:L:?2	R:R:R380	7.79	2	Yes	No	0	5	0	1
L:L:?2	R:R:F381	14.2	2	Yes	No	0	4	0	1
L:L:?2	R:R:L384	4.04	2	Yes	No	0	5	0	1
R:R:P137	R:R:S31	3.56	2	No	Yes	3	4	2	1
R:R:E138	R:R:S31	7.19	0	No	Yes	2	4	2	1
R:R:S31	R:R:T378	9.59	2	Yes	No	4	2	1	2
R:R:L32	R:R:W214	3.42	0	No	Yes	4	1	1	2
R:R:E34	R:R:W33	4.36	0	Yes	Yes	4	3	2	1
R:R:Q37	R:R:W33	12.05	0	No	Yes	4	3	2	1
R:R:Q221	R:R:W33	6.57	2	No	Yes	4	3	1	1
R:R:F381	R:R:W33	16.04	2	No	Yes	4	3	1	1
R:R:E34	R:R:T378	8.47	0	Yes	No	4	2	2	2
R:R:V36	R:R:W214	8.58	0	No	Yes	2	1	1	2
R:R:L218	R:R:V36	4.47	0	No	No	3	2	2	1
R:R:L218	R:R:Q37	3.99	0	No	No	3	4	2	2
R:R:P137	R:R:T378	3.5	2	No	No	3	2	2	2
R:R:L142	R:R:W203	4.56	0	No	Yes	3	3	2	1
R:R:D198	R:R:Y145	12.64	2	Yes	Yes	7	5	2	2
R:R:W203	R:R:Y145	7.72	2	Yes	Yes	3	5	1	2
R:R:M204	R:R:Y145	17.96	2	No	Yes	3	5	2	2
R:R:D198	R:R:K197	8.3	2	Yes	Yes	7	6	2	1
R:R:K197	R:R:M233	8.64	0	Yes	No	6	6	1	2
R:R:D198	R:R:W203	6.7	2	Yes	Yes	7	3	2	1
R:R:L201	R:R:Y220	7.03	0	No	Yes	7	3	1	2
R:R:M204	R:R:W203	6.98	2	No	Yes	3	3	2	1
R:R:L217	R:R:S206	4.5	0	No	No	4	4	1	2
R:R:C226	R:R:Y220	8.06	0	No	Yes	9	3	2	2
R:R:C296	R:R:Q221	6.1	2	No	No	9	4	1	1
R:R:C226	R:R:C296	7.28	0	No	No	9	9	2	1
R:R:F230	R:R:Q234	16.4	0	No	No	5	7	1	2
R:R:R299	R:R:R380	22.39	2	Yes	No	4	5	2	1
R:R:L384	R:R:R380	9.72	2	No	No	5	5	1	1
R:R:K197	R:R:V229	3.04	0	Yes	No	6	7	1	2
R:R:F230	R:R:W284	3.01	0	No	Yes	5	8	1	2
L:L:?2	R:R:T298	2.58	2	Yes	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7LCI_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	368
Number of Links	420
Number of Hubs	56
Number of Links mediated by Hubs	228
Number of Communities	12
Number of Nodes involved in Communities	91
Number of Links involved in Communities	122

Path Summary
Number Of Nodes in MetaPath	58
Number Of Links MetaPath	57
Number of Shortest Paths	446199
Length Of Smallest Path	3
Average Path Length	19.9997
Length of Longest Path	40
Minimum Path Strength	1.135
Average Path Strength	7.008
Maximum Path Strength	23.99
Minimum Path Correlation	0.7
Average Path Correlation	0.949656
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	48.1845
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	55.7034
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network • glucagon receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • amide binding • peptide hormone binding • hormone binding • glucagon-like peptide 1 receptor activity • positive regulation of cytosolic calcium ion concentration • heart process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • heart contraction • blood circulation • regulation of blood pressure • positive regulation of blood pressure • response to psychosocial stress • cell surface receptor signaling pathway • behavior • learning or memory • protein targeting • protein transmembrane transport • post-translational protein targeting to membrane, translocation • establishment of protein localization to endoplasmic reticulum • establishment of protein localization to membrane • intracellular protein transmembrane transport • post-translational protein targeting to endoplasmic reticulum membrane • localization within membrane • protein targeting to membrane • transmembrane transport • establishment of protein localization to organelle • intracellular protein transport • protein targeting to ER • negative regulation of blood pressure
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • FnI-like domain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • FnI-like domain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	UK4
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	UK4
Name	PF-06882961
Synonyms	PF-06882961
Identifier
Formula	C31 H30 F N5 O4
Molecular Weight	555.599
SMILES
PubChem	134611040
Formal Charge	0
Total Atoms	71
Total Chiral Atoms	1
Total Bonds	76
Total Aromatic Bonds	22


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43220
Sequence	>7LCI_nogp_Chain_R A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D L P W R D L S E C E E S K R G E R S S P E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F R H L H C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S T A A Q Q H Q W D G L L S Y Q D S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S V F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E D E G C W T R N S N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L M C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M D E H A R G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E V Q L E F R K S W E R W R L E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	7E14	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738	Gs/β1/γ2	2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7E14 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738		2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7DUQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738	Gs/β1/γ2	2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DUQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738		2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DUR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7DUR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	5VEW	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.7	2017-05-24	doi.org/10.1038/nature22378
	6LN2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.2	2020-03-18	doi.org/10.1038/s41467-020-14934-5
	6KJV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.1	2019-11-13	doi.org/10.1107/S2052252519013496
	5VEX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	NNC0640	-	3	2017-05-17	doi.org/10.1038/nature22378
	9IVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839	chim(NtGi1-Gs)/β2/γ2	3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	9IVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839		3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	6VCB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440	Gs/β1/γ2	3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	6VCB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440		3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	9IVG	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	chim(NtGi1-Gs)/β1/γ2	3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	9IVG (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-		3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	7RTB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-	Gs/β1/γ2	2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7RTB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-		2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7KI0	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI0 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	6X18	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X18 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	7LCI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCJ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	2.82	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCK	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	3.24	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7S15	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 134611223	-	-	3.8	2022-06-08	doi.org/10.1021/acs.jmedchem.1c01856
	9J1P	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-	chim(NtGi1-Gs)/β1/γ2	2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	9J1P (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-		2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	5VAI	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-	Gs/β1/γ2	4.1	2017-05-24	doi.org/10.1038/nature22394
	5VAI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-		4.1	2017-05-24	doi.org/10.1038/nature22394
	5NX2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	-	3.7	2017-06-14	doi.org/10.1038/nature22800
	6B3J	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-	Gs/β1/γ2	3.3	2018-02-21	doi.org/10.1038/nature25773
	6B3J (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-		3.3	2018-02-21	doi.org/10.1038/nature25773
	8WG7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WG7 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	7C2E	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-	Gs/β1/γ2	4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	7C2E (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-		4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	7LLL	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLL (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-	Gs/β1/γ2	3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-		3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7FIM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-	Gs/β1/γ2	3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-		3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBH	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7VBH (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-		3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7S1M	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-	Gs/β1/γ2	2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S1M (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-		2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	6XOX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-	chim(NtGi1-Gs)/β1/γ2	3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	6XOX (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-		3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	7RG9	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RG9 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7X8R	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-	Gs/β1/γ2	2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8R (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-		2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-	Gs/β1/γ2	3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-		3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	8JIP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-	chim(NtGi1-Gs)/β1/γ2	2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-		2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-	chim(NtGi1-Gs)/β1/γ2	2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-		2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIS	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-	chim(NtGi1-Gs)/β1/γ2	2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8JIS (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-		2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8YW3	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	9EBN	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBN (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-	Gs/β1/γ2	3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-		3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	8YWF	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ2	2.74	2025-04-16	To be published
	8YWF (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.74	2025-04-16	To be published
	9BYO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-	Gs/β1/γ2	2.31	2025-06-11	To be published
	9BYO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-		2.31	2025-06-11	To be published
	9C0K	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	2.72	2025-06-11	To be published
	9C0K (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		2.72	2025-06-11	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7LCI_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.