psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L379	R:R:S31	7.51	No	No	0	3	4
2	L:L:?1	R:R:L32	5.41	Yes	No	0	0	4
3	R:R:E34	R:R:W33	3.27	No	Yes	0	4	3
4	R:R:Q37	R:R:W33	3.29	No	Yes	0	4	3
5	R:R:F381	R:R:W33	19.04	No	Yes	2	4	3
6	L:L:?1	R:R:W33	11.88	Yes	Yes	2	0	3
7	R:R:E34	R:R:T378	7.06	No	No	0	4	2
8	R:R:P90	R:R:T35	8.74	No	No	0	4	5
9	R:R:D215	R:R:V36	4.38	Yes	No	0	3	2
10	L:L:?1	R:R:V36	8.74	Yes	No	0	0	2
11	R:R:K38	R:R:W87	10.44	No	Yes	0	4	3
12	R:R:E68	R:R:W39	5.45	No	Yes	0	4	5
13	R:R:W39	R:R:Y88	15.43	Yes	Yes	0	5	5
14	R:R:D215	R:R:W39	24.57	Yes	Yes	0	3	5
15	R:R:R40	R:R:S219	7.91	No	No	0	2	5
16	R:R:E294	R:R:R40	16.28	No	No	0	4	2
17	R:R:E41	R:R:R44	11.63	No	No	0	4	3
18	R:R:E41	R:R:W87	3.27	No	Yes	0	4	3
19	R:R:C71	R:R:Y42	4.03	No	Yes	0	9	6
20	R:R:P86	R:R:Y42	16.69	No	Yes	1	8	6
21	R:R:Y42	R:R:Y88	4.96	Yes	Yes	1	6	5
22	R:R:Q47	R:R:R43	7.01	No	No	0	3	4
23	R:R:Q45	R:R:W87	7.67	No	Yes	0	5	3
24	R:R:C46	R:R:L50	3.17	No	No	0	8	4
25	R:R:C46	R:R:F66	6.98	No	No	0	8	7
26	R:R:C46	R:R:C71	7.28	No	No	0	8	9
27	R:R:D53	R:R:L50	5.43	No	No	4	3	4
28	R:R:L50	R:R:R64	3.64	No	No	4	4	4
29	R:R:E52	R:R:P54	4.72	No	No	0	2	2
30	R:R:D53	R:R:R64	17.87	No	No	4	3	4
31	R:R:F61	R:R:P55	5.78	No	Yes	5	3	1
32	R:R:D74	R:R:P55	8.05	No	Yes	5	3	1
33	R:R:F61	R:R:N63	7.25	No	No	0	3	4
34	R:R:D74	R:R:F61	8.36	No	No	5	3	3
35	R:R:C104	R:R:C62	7.28	No	No	1	9	9
36	R:R:C62	R:R:W110	20.89	No	Yes	1	9	9
37	R:R:T65	R:R:W110	3.64	No	Yes	0	5	9
38	R:R:E68	R:R:F66	11.66	No	No	0	4	7
39	R:R:D67	R:R:W72	6.7	No	Yes	1	9	9
40	R:R:D67	R:R:R102	11.91	No	Yes	1	9	8
41	R:R:D67	R:R:R121	10.72	No	Yes	1	9	6
42	R:R:Y69	R:R:Y88	4.96	Yes	Yes	1	6	5
43	R:R:L89	R:R:Y69	4.69	Yes	Yes	1	5	6
44	R:R:R121	R:R:Y69	12.35	Yes	Yes	1	6	6
45	R:R:H212	R:R:Y69	7.62	No	Yes	0	3	6
46	R:R:A70	R:R:W72	3.89	No	Yes	0	5	9
47	R:R:V81	R:R:W72	4.9	No	Yes	0	6	9
48	R:R:V83	R:R:W72	3.68	No	Yes	0	5	9
49	R:R:V100	R:R:W72	3.68	No	Yes	0	7	9
50	R:R:R102	R:R:W72	20.99	Yes	Yes	1	8	9
51	R:R:R121	R:R:W72	5	Yes	Yes	1	6	9
52	R:R:E76	R:R:P77	3.14	No	No	0	1	4
53	R:R:E76	R:R:S79	8.62	No	No	0	1	5
54	R:R:C104	R:R:P77	5.65	No	No	0	9	4
55	R:R:F103	R:R:G78	3.01	No	No	0	4	7
56	R:R:F103	R:R:F80	4.29	No	No	0	4	4
57	R:R:N82	R:R:Y101	4.65	No	Yes	0	4	5
58	R:R:H99	R:R:S84	8.37	No	No	0	4	4
59	R:R:C126	R:R:C85	7.28	No	No	0	9	9
60	R:R:P86	R:R:Y88	6.95	No	Yes	1	8	5
61	R:R:L89	R:R:Y88	8.21	Yes	Yes	1	5	5
62	R:R:L89	R:R:P90	3.28	Yes	No	1	5	4
63	R:R:L89	R:R:W91	14.81	Yes	No	1	5	4
64	R:R:A92	R:R:L89	3.15	No	Yes	0	5	5
65	R:R:P90	R:R:W91	6.76	No	No	1	4	4
66	R:R:E125	R:R:G98	3.27	No	No	0	5	4
67	R:R:D122	R:R:Y101	3.45	No	Yes	0	7	5
68	R:R:E125	R:R:Y101	4.49	No	Yes	0	5	5
69	R:R:R102	R:R:W110	13.99	Yes	Yes	1	8	9
70	R:R:R102	R:R:R121	12.79	Yes	Yes	1	8	6
71	R:R:F103	R:R:L111	10.96	No	No	0	4	4
72	R:R:C104	R:R:W110	5.22	No	Yes	1	9	9
73	R:R:E107	R:R:T105	4.23	No	No	0	5	4
74	R:R:L111	R:R:W120	3.42	No	No	0	4	5
75	R:R:P119	R:R:Q112	6.32	No	No	0	6	3
76	R:R:D114	R:R:S117	8.83	No	No	0	4	7
77	R:R:L118	R:R:P119	3.28	No	No	0	4	6
78	R:R:L123	R:R:R121	6.07	No	Yes	0	5	6
79	R:R:D122	R:R:S124	5.89	No	No	0	7	5
80	R:R:E138	R:R:L141	3.98	No	No	0	2	5
81	R:R:F143	R:R:I147	7.54	No	No	0	4	6
82	R:R:Y145	R:R:Y148	7.94	Yes	Yes	0	5	7
83	R:R:T149	R:R:Y145	7.49	No	Yes	0	7	5
84	R:R:D198	R:R:Y145	13.79	No	Yes	0	7	5
85	R:R:L201	R:R:Y145	9.38	No	Yes	0	7	5
86	R:R:K202	R:R:Y145	3.58	No	Yes	0	4	5
87	R:R:I147	R:R:S389	4.64	No	No	0	6	5
88	R:R:Y148	R:R:Y152	3.97	Yes	Yes	2	7	7
89	R:R:F385	R:R:Y148	9.28	Yes	Yes	2	6	7
90	R:R:L388	R:R:Y148	8.21	No	Yes	2	7	7
91	R:R:F393	R:R:G151	3.01	No	No	0	7	8
92	R:R:R190	R:R:Y152	13.38	No	Yes	0	8	7
93	R:R:V194	R:R:Y152	7.57	No	Yes	0	7	7
94	R:R:L388	R:R:Y152	7.03	No	Yes	2	7	7
95	R:R:S392	R:R:Y152	19.08	No	Yes	0	9	7
96	R:R:L154	R:R:L396	5.54	No	No	0	5	7
97	R:R:G395	R:R:S155	3.71	No	No	0	9	9
98	R:R:F156	R:R:V160	3.93	Yes	No	6	7	3
99	R:R:F156	R:R:I188	6.28	Yes	No	6	7	7
100	R:R:A191	R:R:F156	4.16	No	Yes	0	7	7
101	R:R:F156	R:R:L192	3.65	Yes	No	0	7	3
102	R:R:F184	R:R:L159	8.53	Yes	Yes	0	8	9
103	R:R:F187	R:R:L159	3.65	Yes	Yes	0	8	9
104	R:R:A399	R:R:L159	3.15	No	Yes	0	8	9
105	R:R:I188	R:R:V160	3.07	No	No	6	7	3
106	R:R:F169	R:R:I165	7.54	Yes	No	7	7	8
107	R:R:F413	R:R:I165	5.02	No	No	7	5	8
108	R:R:L166	R:R:L172	4.15	No	Yes	0	8	9
109	R:R:L166	R:R:L181	4.15	No	No	0	8	6
110	R:R:E412	R:R:F169	10.49	No	Yes	0	8	7
111	R:R:F169	R:R:F413	6.43	Yes	No	7	7	5
112	R:R:F169	R:R:S416	3.96	Yes	No	0	7	5
113	R:R:E412	R:R:H171	16	No	No	0	8	7
114	R:R:L172	R:R:N177	4.12	Yes	No	0	9	9
115	R:R:E408	R:R:L172	3.98	No	Yes	0	9	9
116	R:R:L172	R:R:V409	5.96	Yes	No	0	9	9
117	R:R:H173	R:R:Y178	15.24	No	No	0	7	6
118	R:R:C174	R:R:N177	6.3	No	No	0	8	9
119	R:R:T175	R:R:Y250	6.24	No	Yes	0	7	8
120	R:R:R176	R:R:Y250	3.09	No	Yes	0	9	8
121	R:R:E408	R:R:R176	5.82	No	No	0	9	9
122	R:R:F266	R:R:Y178	6.19	No	No	0	6	6
123	R:R:E247	R:R:H180	9.85	Yes	No	0	9	9
124	R:R:H180	R:R:Y402	16.33	No	No	0	9	8
125	R:R:N182	R:R:W243	7.91	No	Yes	8	9	9
126	R:R:N182	R:R:W274	3.39	No	No	8	9	9
127	R:R:F187	R:R:L183	6.09	Yes	No	0	8	9
128	R:R:L183	R:R:L244	4.15	No	No	0	9	9
129	R:R:E247	R:R:L183	3.98	Yes	No	0	9	9
130	R:R:F184	R:R:V398	5.24	Yes	No	0	8	9
131	R:R:F184	R:R:Y402	3.09	Yes	No	0	8	8
132	R:R:N240	R:R:S186	7.45	No	No	0	9	9
133	R:R:S186	R:R:W243	6.18	No	Yes	0	9	9
134	R:R:F187	R:R:N240	19.33	Yes	No	0	8	9
135	R:R:F187	R:R:G395	3.01	Yes	No	0	8	9
136	R:R:R190	R:R:V237	11.77	No	No	0	8	6
137	R:R:N240	R:R:R190	9.64	No	No	0	9	8
138	R:R:M233	R:R:S193	3.07	No	No	0	6	6
139	R:R:C236	R:R:S193	5.16	No	No	0	5	6
140	R:R:M233	R:R:V194	3.04	No	No	0	6	7
141	R:R:K197	R:R:V229	3.04	No	No	0	6	7
142	R:R:K197	R:R:M233	8.64	No	No	0	6	6
143	L:L:?1	R:R:L201	7.22	Yes	No	0	0	7
144	R:R:K202	R:R:W203	5.8	No	No	0	4	3
145	R:R:M204	R:R:T207	4.52	No	No	0	3	3
146	R:R:M204	R:R:W214	8.14	No	No	0	3	1
147	R:R:S206	R:R:Y205	8.9	No	No	0	4	3
148	R:R:Q210	R:R:S206	4.33	No	No	0	4	4
149	R:R:A208	R:R:D215	6.18	No	Yes	0	4	3
150	R:R:Q211	R:R:W214	4.38	No	No	0	4	1
151	R:R:D215	R:R:H212	6.3	Yes	No	0	3	3
152	R:R:L217	R:R:Y220	3.52	No	No	0	4	3
153	L:L:?1	R:R:L218	13.53	Yes	No	0	0	3
154	R:R:C296	R:R:D222	3.11	No	No	2	9	6
155	L:L:?1	R:R:D222	3.54	Yes	No	2	0	6
156	R:R:C226	R:R:C296	7.28	No	No	0	9	9
157	R:R:K288	R:R:R227	8.66	Yes	No	3	8	8
158	R:R:E292	R:R:R227	16.28	Yes	No	3	6	8
159	R:R:F230	R:R:W284	3.01	No	Yes	0	5	8
160	L:L:?1	R:R:F230	11.12	Yes	No	0	0	5
161	R:R:L231	R:R:W284	5.69	No	Yes	0	5	8
162	R:R:Q234	R:R:W284	15.33	No	Yes	3	7	8
163	R:R:I309	R:R:Q234	8.23	No	No	3	7	7
164	R:R:P277	R:R:Y235	5.56	Yes	No	0	9	9
165	R:R:L278	R:R:Y235	4.69	No	No	0	3	9
166	R:R:V281	R:R:Y235	10.09	No	No	0	6	9
167	R:R:A239	R:R:P277	3.74	No	Yes	0	8	9
168	R:R:I313	R:R:Y241	7.25	Yes	No	0	7	8
169	R:R:I317	R:R:Y241	4.84	No	No	0	7	8
170	R:R:E364	R:R:Y241	10.1	Yes	No	0	8	8
171	R:R:V276	R:R:Y242	8.83	Yes	Yes	9	3	6
172	R:R:P277	R:R:Y242	8.34	Yes	Yes	9	9	6
173	R:R:F280	R:R:Y242	5.16	No	Yes	0	5	6
174	R:R:I313	R:R:Y242	4.84	Yes	Yes	0	7	6
175	R:R:V246	R:R:W243	3.68	No	Yes	0	8	9
176	R:R:G273	R:R:W243	7.04	No	Yes	0	9	9
177	R:R:W243	R:R:W274	13.12	Yes	No	8	9	9
178	R:R:V246	R:R:Y269	3.79	No	Yes	0	8	7
179	R:R:E247	R:R:L359	5.3	Yes	No	0	9	9
180	R:R:G248	R:R:L360	5.13	No	No	0	8	9
181	R:R:L254	R:R:Y250	11.72	No	Yes	0	8	8
182	R:R:Y250	R:R:Y269	5.96	Yes	Yes	0	8	7
183	R:R:A256	R:R:Y252	6.67	No	No	0	6	8
184	R:R:F257	R:R:Y252	9.28	No	No	0	5	8
185	R:R:F257	R:R:T253	9.08	No	No	0	5	7
186	R:R:E262	R:R:F260	5.83	No	No	0	6	7
187	R:R:I265	R:R:W264	3.52	No	No	0	5	5
188	R:R:I265	R:R:Y269	4.84	No	Yes	0	5	7
189	R:R:F266	R:R:V270	6.55	No	No	0	6	5
190	R:R:V270	R:R:W274	6.13	No	No	0	5	9
191	R:R:G273	R:R:I272	3.53	No	No	0	9	6
192	R:R:I272	R:R:V276	4.61	No	Yes	0	6	3
193	R:R:P277	R:R:V276	3.53	Yes	Yes	9	9	3
194	R:R:F280	R:R:P312	11.56	No	No	0	5	8
195	R:R:P283	R:R:V282	3.53	No	No	0	5	3
196	R:R:W284	R:R:W297	17.81	Yes	Yes	3	8	8
197	R:R:I309	R:R:W284	19.97	No	Yes	3	7	8
198	R:R:G285	R:R:K288	3.49	No	Yes	0	5	8
199	R:R:V287	R:R:Y291	3.79	No	No	0	4	3
200	R:R:E292	R:R:K288	4.05	Yes	Yes	3	6	8
201	R:R:K288	R:R:W297	15.08	Yes	Yes	3	8	8
202	R:R:L290	R:R:Y291	3.52	No	No	0	3	3
203	R:R:Y291	R:R:Y305	5.96	No	Yes	0	3	4
204	R:R:E292	R:R:W297	13.08	Yes	Yes	3	6	8
205	L:L:?1	R:R:C296	5.17	Yes	No	2	0	9
206	R:R:W297	R:R:Y305	16.4	Yes	Yes	0	8	4
207	R:R:R299	R:R:T298	3.88	No	No	0	4	5
208	L:L:?1	R:R:T298	10.57	Yes	No	0	0	5
209	R:R:G377	R:R:R299	6	No	No	0	4	4
210	R:R:N300	R:R:S301	7.45	No	No	0	6	3
211	R:R:N302	R:R:N304	8.17	No	No	0	5	3
212	R:R:N302	R:R:Y305	17.44	No	Yes	0	5	4
213	R:R:M303	R:R:W306	12.8	No	No	0	5	6
214	R:R:I308	R:R:N304	8.5	No	No	0	8	3
215	R:R:E373	R:R:W306	13.08	No	No	0	4	6
216	R:R:L307	R:R:L311	8.3	No	No	0	7	4
217	R:R:L314	R:R:R310	4.86	No	No	0	4	6
218	R:R:F315	R:R:V319	5.24	No	No	0	4	6
219	R:R:I317	R:R:V365	3.07	No	No	0	7	6
220	R:R:A368	R:R:I317	3.25	No	No	0	6	7
221	R:R:I323	R:R:V319	3.07	No	No	0	8	6
222	R:R:L360	R:R:N320	12.36	No	No	0	9	9
223	R:R:F321	R:R:V325	5.24	Yes	No	0	6	5
224	R:R:F321	R:R:V365	10.49	Yes	No	0	6	6
225	R:R:F324	R:R:I328	10.05	No	No	0	9	7
226	R:R:F324	R:R:L356	6.09	No	No	0	9	9
227	R:R:F324	R:R:T362	7.78	No	No	0	9	7
228	R:R:S352	R:R:V331	3.23	No	No	0	9	8
229	R:R:D344	R:R:I345	4.2	No	No	0	7	5
230	R:R:K351	R:R:R348	3.71	No	No	0	8	8
231	R:R:I357	R:R:T353	3.04	No	No	0	8	9
232	R:R:L401	R:R:T355	4.42	No	No	0	8	8
233	R:R:I357	R:R:P358	3.39	No	No	0	8	9
234	R:R:I357	R:R:T362	3.04	No	No	0	8	7
235	R:R:M397	R:R:P358	3.35	No	No	0	5	9
236	R:R:L401	R:R:P358	3.28	No	No	0	8	9
237	R:R:L359	R:R:Y402	10.55	No	No	0	9	8
238	R:R:G361	R:R:H363	3.18	No	No	0	9	8
239	R:R:E364	R:R:H363	11.08	Yes	No	0	8	8
240	R:R:H363	R:R:Q394	7.42	No	No	0	8	9
241	R:R:E364	R:R:E387	3.81	Yes	Yes	10	8	8
242	R:R:E364	R:R:T391	4.23	Yes	No	10	8	6
243	R:R:F369	R:R:V365	3.93	No	No	0	4	6
244	R:R:E387	R:R:F367	5.83	Yes	No	0	8	7
245	R:R:F367	R:R:F390	6.43	No	No	0	7	6
246	R:R:E373	R:R:R380	9.3	No	Yes	0	4	5
247	R:R:G377	R:R:R380	4.5	No	Yes	0	4	5
248	R:R:L384	R:R:R380	6.07	No	Yes	2	5	5
249	L:L:?1	R:R:R380	6.34	Yes	Yes	2	0	5
250	L:L:?1	R:R:F381	18.26	Yes	No	2	0	4
251	R:R:F385	R:R:L384	4.87	Yes	No	2	6	5
252	L:L:?1	R:R:L384	11.73	Yes	No	2	0	5
253	R:R:F385	R:R:L388	3.65	Yes	No	2	6	7
254	L:L:?1	R:R:F385	3.97	Yes	Yes	2	0	6
255	R:R:E387	R:R:T391	7.06	Yes	No	10	8	6
256	R:R:F390	R:R:S389	3.96	No	No	0	6	5
257	R:R:L401	R:R:V405	4.47	No	No	0	8	6
258	R:R:N406	R:R:N407	4.09	No	No	0	9	6
259	R:R:E408	R:R:N406	11.83	No	No	0	9	9
260	R:R:N406	R:R:V409	8.87	No	No	0	9	9
261	R:R:R421	R:R:W417	5	No	No	0	4	5
262	R:R:E418	R:R:L422	5.3	No	No	0	4	4
263	R:R:L144	R:R:S389	3	No	No	0	6	5
264	R:R:L181	R:R:S163	3	No	No	0	6	6
265	R:R:L245	R:R:V249	2.98	No	No	0	8	6
266	R:R:L245	R:R:V319	2.98	No	No	0	8	6
267	R:R:L251	R:R:V327	2.98	No	No	0	9	9
268	R:R:L255	R:R:V327	2.98	No	No	0	8	9
269	R:R:L278	R:R:V282	2.98	No	No	0	3	3
270	R:R:L356	R:R:V327	2.98	No	No	0	9	9
271	R:R:L111	R:R:T105	2.95	No	No	0	4	4
272	R:R:I146	R:R:K202	2.91	No	No	0	4	4
273	R:R:K383	R:R:M371	2.88	No	No	0	7	7
274	R:R:E34	R:R:V30	2.85	No	No	0	4	2
275	R:R:I382	R:R:L141	2.85	No	No	0	4	5
276	R:R:I188	R:R:L159	2.85	No	Yes	0	7	9
277	R:R:I330	R:R:L255	2.85	No	No	0	9	8
278	R:R:I345	R:R:L335	2.85	No	No	0	5	8
279	R:R:I400	R:R:L396	2.85	No	No	0	6	7
280	R:R:G216	R:R:W39	2.81	No	Yes	0	2	5
281	R:R:G75	R:R:W110	2.81	No	Yes	0	7	9
282	R:R:A162	R:R:F184	2.77	No	Yes	0	9	8
283	R:R:L167	R:R:L181	2.77	No	No	0	3	6
284	R:R:L356	R:R:L360	2.77	No	No	0	9	9
285	R:R:L307	R:R:N304	2.75	No	No	0	7	3
286	R:R:E247	R:R:I179	2.73	Yes	No	0	9	8
287	R:R:E387	R:R:M371	2.71	Yes	No	0	8	7
288	R:R:E138	R:R:L142	2.65	No	No	0	2	3
289	R:R:R348	R:R:S352	2.64	No	No	0	8	9
290	R:R:F413	R:R:V409	2.62	No	No	0	5	9
291	R:R:C126	R:R:W91	2.61	No	No	0	9	4
292	R:R:F321	R:R:T362	2.59	Yes	No	0	6	7
293	R:R:S301	R:R:Y305	2.54	No	Yes	0	3	4
294	R:R:D372	R:R:H374	2.52	No	No	0	5	3
295	R:R:I309	R:R:R310	2.51	No	No	0	7	6
296	R:R:I313	R:R:R310	2.51	Yes	No	0	7	6
297	R:R:I330	R:R:R326	2.51	No	No	0	9	8
298	R:R:T253	R:R:Y269	2.5	No	Yes	0	7	7
299	R:R:S219	R:R:W39	2.47	No	Yes	0	5	5
300	R:R:H99	R:R:Q97	2.47	No	No	0	4	4
301	R:R:F385	R:R:L141	2.44	Yes	No	0	6	5
302	R:R:F260	R:R:L254	2.44	No	No	0	7	8
303	R:R:L268	R:R:W264	2.28	No	No	0	2	5
304	R:R:F156	R:R:F195	2.14	Yes	No	0	7	7
305	R:R:F80	R:R:Y101	2.06	No	Yes	0	4	5
306	R:R:G275	R:R:P277	2.03	No	Yes	0	6	9
307	R:R:C126	R:R:G98	1.96	No	No	0	9	4
308	R:R:P54	R:R:P55	1.95	No	Yes	0	2	1
309	R:R:P55	R:R:P56	1.95	Yes	No	0	1	1
310	R:R:W87	R:R:Y42	1.93	Yes	Yes	0	3	6
311	R:R:A162	R:R:C403	1.81	No	No	0	9	9
312	R:R:A158	R:R:A399	1.79	No	No	0	7	8
313	R:R:P96	R:R:V95	1.77	No	No	0	3	5
314	R:R:G248	R:R:I323	1.76	No	No	0	8	8
315	R:R:C71	R:R:S49	1.72	No	No	0	9	2
316	R:R:G108	R:R:L60	1.71	No	No	0	9	1
317	R:R:C329	R:R:V325	1.71	No	No	0	7	5
318	R:R:L60	R:R:P77	1.64	No	No	0	1	4
319	R:R:E292	R:R:G295	1.64	Yes	No	0	6	4
320	R:R:E294	R:R:G295	1.64	No	No	0	4	4
321	R:R:S93	R:R:S94	1.63	No	No	0	3	4
322	R:R:S225	R:R:V229	1.62	No	No	0	3	7
323	R:R:A238	R:R:I313	1.62	No	Yes	0	6	7
324	R:R:D53	R:R:P54	1.61	No	No	0	3	2
325	R:R:A200	R:R:M204	1.61	No	No	0	4	3
326	R:R:A375	R:R:M303	1.61	No	No	0	4	5
327	R:R:C236	R:R:L189	1.59	No	No	0	5	7
328	R:R:A158	R:R:L396	1.58	No	No	0	7	7
329	R:R:A316	R:R:L245	1.58	No	No	0	7	8
330	R:R:I146	R:R:V150	1.54	No	No	0	4	5
331	R:R:I196	R:R:V229	1.54	No	No	0	5	7
332	R:R:I328	R:R:V332	1.54	No	No	0	7	6
333	R:R:I366	R:R:V370	1.54	No	No	0	6	5
334	R:R:K336	R:R:V332	1.52	No	No	0	6	6
335	R:R:I382	R:R:T386	1.52	No	No	0	4	4
336	R:R:A106	R:R:E107	1.51	No	No	0	1	5
337	R:R:F321	R:R:G318	1.51	Yes	No	0	6	4
338	R:R:L32	R:R:S206	1.5	No	No	0	4	4
339	R:R:L232	R:R:S193	1.5	No	No	0	5	6
340	R:R:L224	R:R:S223	1.5	No	No	0	3	4
341	R:R:K351	R:R:T355	1.5	No	No	0	8	8
342	R:R:L279	R:R:V276	1.49	No	Yes	0	4	3
343	R:R:L349	R:R:V332	1.49	No	No	0	9	6
344	R:R:L109	R:R:T105	1.47	No	No	0	5	4
345	R:R:D114	R:R:S116	1.47	No	No	0	4	5
346	R:R:I330	R:R:K334	1.45	No	No	0	9	9
347	R:R:I382	R:R:L379	1.43	No	No	0	4	3
348	R:R:A153	R:R:F195	1.39	No	No	0	6	7
349	R:R:L224	R:R:L228	1.38	No	No	0	3	4
350	R:R:P73	R:R:W72	1.35	No	Yes	0	5	9
351	R:R:P119	R:R:W110	1.35	No	Yes	0	6	9
352	R:R:E412	R:R:K415	1.35	No	No	0	8	7
353	R:R:L218	R:R:Q221	1.33	No	No	0	3	4
354	R:R:R267	R:R:S271	1.32	No	No	0	4	3
355	R:R:F257	R:R:V259	1.31	No	No	0	5	6
356	R:R:F404	R:R:V405	1.31	No	No	0	8	6
357	R:R:H99	R:R:N82	1.28	No	No	0	4	4
358	R:R:E127	R:R:E128	1.27	No	No	0	2	3
359	R:R:K415	R:R:R419	1.24	No	No	0	7	7
360	R:R:L224	R:R:R227	1.21	No	No	0	3	8
361	R:R:L335	R:R:R348	1.21	No	No	0	8	8
362	R:R:K288	R:R:Y289	1.19	Yes	No	0	8	3
363	R:R:F266	R:R:Q263	1.17	No	No	0	6	5
364	R:R:E68	R:R:R43	1.16	No	No	0	4	4
365	R:R:K113	R:R:W120	1.16	No	No	0	4	5
366	R:R:L217	R:R:W214	1.14	No	No	0	4	1
367	R:R:E423	R:R:W420	1.09	No	No	0	4	4
368	R:R:R44	R:R:R48	1.07	No	No	0	3	4
369	R:R:W417	R:R:W420	0.94	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:W33	9.37	4	2	3
2	R:R:W39	10.146	5	0	5
3	R:R:Y42	6.9025	4	1	6
4	R:R:P55	4.4325	4	5	1
5	R:R:Y69	7.405	4	1	6
6	R:R:W72	6.27375	8	1	9
7	R:R:W87	5.8275	4	0	3
8	R:R:Y88	8.102	5	1	5
9	R:R:L89	6.828	5	1	5
10	R:R:Y101	3.6625	4	0	5
11	R:R:R102	14.92	4	1	8
12	R:R:W110	7.98333	6	1	9
13	R:R:R121	9.386	5	1	6
14	R:R:Y145	8.436	5	0	5
15	R:R:Y148	7.35	4	2	7
16	R:R:Y152	10.206	5	2	7
17	R:R:F156	4.032	5	6	7
18	R:R:L159	4.545	4	0	9
19	R:R:F169	7.105	4	7	7
20	R:R:L172	4.5525	4	0	9
21	R:R:F184	4.9075	4	0	8
22	R:R:F187	8.02	4	0	8
23	R:R:D215	10.3575	4	0	3
24	R:R:Y242	6.7925	4	9	6
25	R:R:W243	7.586	5	8	9
26	R:R:E247	5.465	4	0	9
27	R:R:Y250	6.7525	4	0	8
28	R:R:Y269	4.2725	4	0	7
29	R:R:V276	4.615	4	9	3
30	R:R:P277	4.64	5	9	9
31	R:R:W284	12.362	5	3	8
32	R:R:K288	6.494	5	3	8
33	R:R:E292	8.7625	4	3	6
34	R:R:W297	15.5925	4	3	8
35	R:R:Y305	10.585	4	0	4
36	R:R:I313	4.055	4	0	7
37	R:R:F321	4.9575	4	0	6
38	R:R:E364	7.305	4	10	8
39	R:R:R380	6.5525	4	2	5
40	R:R:F385	4.842	5	2	6
41	R:R:E387	4.8525	4	10	8
42	L:L:?1	9.03692	13	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F385	89.3639	3.97	Yes	Yes	2	0	6
2	L:L:?1	R:R:V36	100	8.74	Yes	No	0	0	2
3	R:R:D215	R:R:V36	99.3625	4.38	Yes	No	0	3	2
4	R:R:D215	R:R:W39	51.3944	24.57	Yes	Yes	0	3	5
5	R:R:W39	R:R:Y88	38.0437	15.43	Yes	Yes	0	5	5
6	R:R:L89	R:R:Y88	27.501	8.21	Yes	Yes	1	5	5
7	R:R:D215	R:R:H212	46.8498	6.3	Yes	No	0	3	3
8	R:R:H212	R:R:Y69	46.0283	7.62	No	Yes	0	3	6
9	R:R:L89	R:R:Y69	25.553	4.69	Yes	Yes	1	5	6
10	R:R:Y42	R:R:Y88	11.7736	4.96	Yes	Yes	1	6	5
11	R:R:E68	R:R:W39	15.4444	5.45	No	Yes	0	4	5
12	R:R:W284	R:R:W297	23.2779	17.81	Yes	Yes	3	8	8
13	R:R:F230	R:R:W284	52.7463	3.01	No	Yes	0	5	8
14	L:L:?1	R:R:F230	53.3865	11.12	Yes	No	0	0	5
15	R:R:C46	R:R:F66	11.0262	6.98	No	No	0	8	7
16	R:R:E68	R:R:F66	12.1088	11.66	No	No	0	4	7
17	R:R:C46	R:R:L50	11.7296	3.17	No	No	0	8	4
18	R:R:R102	R:R:W110	14.7218	13.99	Yes	Yes	1	8	9
19	R:R:R102	R:R:R121	15.5626	12.79	Yes	Yes	1	8	6
20	R:R:R121	R:R:Y69	25.3441	12.35	Yes	Yes	1	6	6
21	R:R:F103	R:R:F80	18.791	4.29	No	No	0	4	4
22	R:R:F80	R:R:Y101	20.8518	2.06	No	Yes	0	4	5
23	R:R:E125	R:R:Y101	35.123	4.49	No	Yes	0	5	5
24	R:R:E125	R:R:G98	37.1397	3.27	No	No	0	5	4
25	R:R:C126	R:R:G98	39.151	1.96	No	No	0	9	4
26	R:R:C126	R:R:W91	43.157	2.61	No	No	0	9	4
27	R:R:L89	R:R:W91	45.0309	14.81	Yes	No	1	5	4
28	R:R:F103	R:R:L111	14.6531	10.96	No	No	0	4	4
29	R:R:E364	R:R:Y241	13.7299	10.1	Yes	No	0	8	8
30	R:R:I313	R:R:Y241	51.2131	7.25	Yes	No	0	7	8
31	R:R:I313	R:R:R310	47.8747	2.51	Yes	No	0	7	6
32	R:R:I309	R:R:R310	48.1769	2.51	No	No	0	7	6
33	R:R:I309	R:R:W284	48.1852	19.97	No	Yes	3	7	8
34	R:R:F385	R:R:Y148	46.1932	9.28	Yes	Yes	2	6	7
35	R:R:Y148	R:R:Y152	47.7813	3.97	Yes	Yes	2	7	7
36	R:R:F385	R:R:L388	46.0228	3.65	Yes	No	2	6	7
37	R:R:L388	R:R:Y152	45.6107	7.03	No	Yes	2	7	7
38	R:R:R190	R:R:Y152	80.1401	13.38	No	Yes	0	8	7
39	R:R:V194	R:R:Y152	16.483	7.57	No	Yes	0	7	7
40	R:R:F187	R:R:L159	25.9404	3.65	Yes	Yes	0	8	9
41	R:R:F187	R:R:N240	38.4393	19.33	Yes	No	0	8	9
42	R:R:N240	R:R:R190	78.8762	9.64	No	No	0	9	8
43	R:R:I188	R:R:L159	10.3641	2.85	No	Yes	0	7	9
44	R:R:F169	R:R:F413	16.2357	6.43	Yes	No	7	7	5
45	R:R:F413	R:R:V409	21.6266	2.62	No	No	0	5	9
46	R:R:L172	R:R:V409	12.2517	5.96	Yes	No	0	9	9
47	R:R:E408	R:R:L172	21.4453	3.98	No	Yes	0	9	9
48	R:R:E408	R:R:R176	37.354	5.82	No	No	0	9	9
49	R:R:R176	R:R:Y250	38.6097	3.09	No	Yes	0	9	8
50	R:R:Y250	R:R:Y269	44.7726	5.96	Yes	Yes	0	8	7
51	R:R:V246	R:R:Y269	55.5791	3.79	No	Yes	0	8	7
52	R:R:V246	R:R:W243	56.7523	3.68	No	Yes	0	8	9
53	R:R:S186	R:R:W243	58.607	6.18	No	Yes	0	9	9
54	R:R:N240	R:R:S186	59.3735	7.45	No	No	0	9	9
55	R:R:N406	R:R:V409	12.128	8.87	No	No	0	9	9
56	R:R:E408	R:R:N406	14.7548	11.83	No	No	0	9	9
57	R:R:E412	R:R:F169	10.8559	10.49	No	Yes	0	8	7
58	R:R:M233	R:R:V194	14.8592	3.04	No	No	0	6	7
59	R:R:I313	R:R:Y242	28.6358	4.84	Yes	Yes	0	7	6
60	R:R:I317	R:R:Y241	40.25	4.84	No	No	0	7	8
61	R:R:V276	R:R:Y242	21.9261	8.83	Yes	Yes	9	3	6
62	R:R:G273	R:R:W243	23.778	7.04	No	Yes	0	9	9
63	R:R:F324	R:R:L356	15.6038	6.09	No	No	0	9	9
64	R:R:F324	R:R:T362	20.1704	7.78	No	No	0	9	7
65	R:R:F321	R:R:T362	33.8975	2.59	Yes	No	0	6	7
66	R:R:F321	R:R:V365	37.1177	10.49	Yes	No	0	6	6
67	R:R:I317	R:R:V365	38.6949	3.07	No	No	0	7	6
68	R:R:G273	R:R:I272	22.9784	3.53	No	No	0	9	6
69	R:R:W297	R:R:Y305	13.4167	16.4	Yes	Yes	0	8	4
70	R:R:I357	R:R:T362	14.6311	3.04	No	No	0	8	7
71	R:R:I357	R:R:P358	12.7463	3.39	No	No	0	8	9
72	R:R:L401	R:R:P358	10.8339	3.28	No	No	0	8	9
73	R:R:I272	R:R:V276	23.3109	4.61	No	Yes	0	6	3

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L32	5.41	2	Yes	No	0	4	0	1
R:R:E34	R:R:W33	3.27	0	No	Yes	4	3	2	1
R:R:Q37	R:R:W33	3.29	0	No	Yes	4	3	2	1
R:R:F381	R:R:W33	19.04	2	No	Yes	4	3	1	1
L:L:?1	R:R:W33	11.88	2	Yes	Yes	0	3	0	1
R:R:D215	R:R:V36	4.38	0	Yes	No	3	2	2	1
L:L:?1	R:R:V36	8.74	2	Yes	No	0	2	0	1
R:R:Y145	R:R:Y148	7.94	0	Yes	Yes	5	7	2	2
R:R:L201	R:R:Y145	9.38	0	No	Yes	7	5	1	2
R:R:F385	R:R:Y148	9.28	2	Yes	Yes	6	7	1	2
R:R:L388	R:R:Y148	8.21	2	No	Yes	7	7	2	2
L:L:?1	R:R:L201	7.22	2	Yes	No	0	7	0	1
L:L:?1	R:R:L218	13.53	2	Yes	No	0	3	0	1
R:R:C296	R:R:D222	3.11	2	No	No	9	6	1	1
L:L:?1	R:R:D222	3.54	2	Yes	No	0	6	0	1
R:R:C226	R:R:C296	7.28	0	No	No	9	9	2	1
R:R:F230	R:R:W284	3.01	0	No	Yes	5	8	1	2
L:L:?1	R:R:F230	11.12	2	Yes	No	0	5	0	1
L:L:?1	R:R:C296	5.17	2	Yes	No	0	9	0	1
R:R:R299	R:R:T298	3.88	0	No	No	4	5	2	1
L:L:?1	R:R:T298	10.57	2	Yes	No	0	5	0	1
R:R:G377	R:R:R299	6	0	No	No	4	4	2	2
R:R:E373	R:R:R380	9.3	0	No	Yes	4	5	2	1
R:R:G377	R:R:R380	4.5	0	No	Yes	4	5	2	1
R:R:L384	R:R:R380	6.07	2	No	Yes	5	5	1	1
L:L:?1	R:R:R380	6.34	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:F381	18.26	2	Yes	No	0	4	0	1
R:R:F385	R:R:L384	4.87	2	Yes	No	6	5	1	1
L:L:?1	R:R:L384	11.73	2	Yes	No	0	5	0	1
R:R:F385	R:R:L388	3.65	2	Yes	No	6	7	1	2
L:L:?1	R:R:F385	3.97	2	Yes	Yes	0	6	0	1
R:R:F385	R:R:L141	2.44	2	Yes	No	6	5	1	2
R:R:L32	R:R:S206	1.5	0	No	No	4	4	1	2
R:R:L218	R:R:Q221	1.33	0	No	No	3	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7C2E_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.01
Number of Linked Nodes	349
Number of Links	369
Number of Hubs	42
Number of Links mediated by Hubs	164
Number of Communities	10
Number of Nodes involved in Communities	53
Number of Links involved in Communities	66

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	78231
Length Of Smallest Path	3
Average Path Length	16.1355
Length of Longest Path	36
Minimum Path Strength	1.015
Average Path Strength	7.01984
Maximum Path Strength	20
Minimum Path Correlation	0.7
Average Path Correlation	0.954472
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	56.2233
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.2156
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • heart process • multicellular organismal process • system process • regulation of biological process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • regulation of blood pressure • positive regulation of blood pressure • cellular response to stimulus • regulation of cellular process • response to stimulus • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to stress • response to psychosocial stress • cell surface receptor signaling pathway • behavior • learning or memory • nervous system process • cognition • transport • secretion • regulation of hormone levels • cell-cell signaling • export from cell • hormone secretion • establishment of localization • localization • secretion by cell • signal release • hormone transport • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • establishment of protein localization • cellular localization • nitrogen compound transport • protein targeting • protein transmembrane transport • establishment of localization in cell • post-translational protein targeting to membrane, translocation • intracellular protein localization • establishment of protein localization to endoplasmic reticulum • establishment of protein localization to membrane • intracellular protein transmembrane transport • intracellular transport • post-translational protein targeting to endoplasmic reticulum membrane • localization within membrane • protein targeting to membrane • transmembrane transport • establishment of protein localization to organelle • protein transport • macromolecule localization • intracellular protein transport • protein targeting to ER • negative regulation of blood pressure • cellular anatomical structure • membrane • cell periphery • plasma membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • amide transport • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • regulation of protein transport • protein secretion • regulation of protein secretion • regulation of secretion • peptide transport • regulation of insulin secretion • peptide hormone secretion • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• FnI-like domain • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• FnI-like domain • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	FFR
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	FFR
Name	2-[[4-[6-[(4-cyano-2-fluoranyl-phenyl)methoxy]pyridin-2-yl]-3,6-dihydro-2~{H}-pyridin-1-yl]methyl]-3-[[(2~{S})-oxetan-2-yl]methyl]imidazo[4,5-b]pyridine-5-carboxylic acid
Synonyms
Identifier
Formula	C30 H27 F N6 O4
Molecular Weight	554.572
SMILES
PubChem	149050799
Formal Charge	0
Total Atoms	68
Total Chiral Atoms	1
Total Bonds	73
Total Aromatic Bonds	22


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43220
Sequence	>7C2E_nogp_Chain_R V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E P E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F R H L H C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S T A A Q Q H Q W D G L L S Y Q D S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S V F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E D E G C W T R N S N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A D I K C R L A K S T L T L I P L L G T H E V I F A F V M D E H A R G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E V Q L E F R K S W E R W R L E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	7E14	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738	Gs/β1/γ2	2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7E14 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738		2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7DUQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738	Gs/β1/γ2	2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DUQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738		2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DUR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7DUR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	5VEW	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.7	2017-05-24	doi.org/10.1038/nature22378
	6LN2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.2	2020-03-18	doi.org/10.1038/s41467-020-14934-5
	6KJV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.1	2019-11-13	doi.org/10.1107/S2052252519013496
	5VEX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	NNC0640	-	3	2017-05-17	doi.org/10.1038/nature22378
	9IVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839	chim(NtGi1-Gs)/β2/γ2	3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	9IVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839		3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	6VCB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440	Gs/β1/γ2	3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	6VCB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440		3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	9IVG	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	chim(NtGi1-Gs)/β1/γ2	3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	9IVG (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-		3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	7RTB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-	Gs/β1/γ2	2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7RTB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-		2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7KI0	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI0 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	6X18	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X18 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	7LCI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCJ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	2.82	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCK	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	3.24	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7S15	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 134611223	-	-	3.8	2022-06-08	doi.org/10.1021/acs.jmedchem.1c01856
	9J1P	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-	chim(NtGi1-Gs)/β1/γ2	2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	9J1P (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-		2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	5VAI	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-	Gs/β1/γ2	4.1	2017-05-24	doi.org/10.1038/nature22394
	5VAI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-		4.1	2017-05-24	doi.org/10.1038/nature22394
	5NX2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	-	3.7	2017-06-14	doi.org/10.1038/nature22800
	6B3J	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-	Gs/β1/γ2	3.3	2018-02-21	doi.org/10.1038/nature25773
	6B3J (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-		3.3	2018-02-21	doi.org/10.1038/nature25773
	8WG7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WG7 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	7C2E	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-	Gs/β1/γ2	4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	7C2E (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-		4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	7LLL	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLL (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-	Gs/β1/γ2	3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-		3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7FIM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-	Gs/β1/γ2	3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-		3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBH	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7VBH (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-		3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7S1M	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-	Gs/β1/γ2	2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S1M (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-		2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	6XOX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-	chim(NtGi1-Gs)/β1/γ2	3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	6XOX (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-		3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	7RG9	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RG9 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7X8R	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-	Gs/β1/γ2	2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8R (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-		2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-	Gs/β1/γ2	3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-		3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	8JIP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-	chim(NtGi1-Gs)/β1/γ2	2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-		2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-	chim(NtGi1-Gs)/β1/γ2	2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-		2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIS	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-	chim(NtGi1-Gs)/β1/γ2	2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8JIS (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-		2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8YW3	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	9EBN	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBN (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-	Gs/β1/γ2	3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-		3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	8YWF	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ2	2.74	2025-04-16	To be published
	8YWF (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.74	2025-04-16	To be published
	9BYO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-	Gs/β1/γ2	2.31	2025-06-11	To be published
	9BYO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-		2.31	2025-06-11	To be published
	9C0K	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	2.72	2025-06-11	To be published
	9C0K (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		2.72	2025-06-11	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7C2E_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.