psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:E21	R:R:S31	4.31	No	No	0	0	4
2	R:R:L32	R:R:Q213	10.65	No	Yes	0	4	4
3	R:R:L32	R:R:W214	5.69	No	Yes	0	4	1
4	L:L:A24	R:R:L32	4.73	No	No	0	0	4
5	R:R:Q37	R:R:W33	17.52	No	No	0	4	3
6	R:R:P90	R:R:T35	5.25	Yes	No	0	4	5
7	L:L:F28	R:R:V36	10.49	Yes	No	0	0	2
8	R:R:Q37	R:R:R40	5.84	No	No	0	4	2
9	R:R:R43	R:R:W39	13	No	Yes	0	4	5
10	R:R:E68	R:R:W39	4.36	No	Yes	2	4	5
11	R:R:W39	R:R:Y88	20.26	Yes	Yes	2	5	5
12	L:L:F28	R:R:W39	8.02	Yes	Yes	2	0	5
13	L:L:L32	R:R:W39	12.53	No	Yes	2	0	5
14	L:L:R36	R:R:W39	11	Yes	Yes	2	0	5
15	R:R:R40	R:R:R44	7.46	No	No	0	2	3
16	R:R:C71	R:R:Y42	9.41	No	Yes	0	9	6
17	R:R:P86	R:R:Y42	5.56	Yes	Yes	2	8	6
18	R:R:W87	R:R:Y42	14.47	No	Yes	0	3	6
19	R:R:Y42	R:R:Y88	10.92	Yes	Yes	2	6	5
20	R:R:Q47	R:R:R43	5.84	No	No	0	3	4
21	R:R:F66	R:R:R43	5.34	No	No	0	7	4
22	R:R:C46	R:R:F66	9.78	No	No	0	8	7
23	R:R:C46	R:R:C71	7.28	No	No	0	8	9
24	R:R:L50	R:R:R64	4.86	No	Yes	0	4	4
25	R:R:E52	R:R:T51	5.64	No	No	0	2	4
26	R:R:D53	R:R:R64	16.68	No	Yes	0	3	4
27	R:R:F61	R:R:P55	4.33	No	No	0	3	1
28	R:R:F61	R:R:P56	5.78	No	No	6	3	1
29	R:R:D74	R:R:P56	9.66	Yes	No	6	3	1
30	R:R:D59	R:R:T58	4.34	No	No	0	3	1
31	R:R:L60	R:R:P77	4.93	No	No	0	1	4
32	R:R:D74	R:R:F61	10.75	Yes	No	6	3	3
33	R:R:C104	R:R:C62	7.28	No	No	0	9	9
34	R:R:C62	R:R:W110	9.14	No	No	0	9	9
35	R:R:P73	R:R:R64	4.32	No	Yes	0	5	4
36	R:R:D74	R:R:R64	19.06	Yes	Yes	0	3	4
37	R:R:E68	R:R:F66	4.66	No	No	0	4	7
38	R:R:D67	R:R:W72	10.05	No	Yes	7	9	9
39	R:R:D67	R:R:R102	7.15	No	Yes	7	9	8
40	R:R:D67	R:R:R121	10.72	No	No	0	9	6
41	L:L:R36	R:R:E68	12.79	Yes	No	2	0	4
42	R:R:P86	R:R:Y69	9.74	Yes	No	2	8	6
43	R:R:L89	R:R:Y69	4.69	Yes	No	2	5	6
44	R:R:L123	R:R:Y69	10.55	Yes	No	0	5	6
45	R:R:A70	R:R:W72	5.19	No	Yes	0	5	9
46	R:R:V81	R:R:W72	6.13	No	Yes	0	6	9
47	R:R:V83	R:R:W72	13.48	No	Yes	0	5	9
48	R:R:R102	R:R:W72	18.99	Yes	Yes	7	8	9
49	R:R:E76	R:R:P77	7.86	No	No	0	1	4
50	R:R:E76	R:R:S79	8.62	No	No	0	1	5
51	R:R:F80	R:R:Y101	6.19	No	Yes	0	4	5
52	R:R:F103	R:R:F80	8.57	No	No	0	4	4
53	R:R:N82	R:R:Y101	6.98	No	Yes	0	4	5
54	R:R:C85	R:R:V95	5.12	No	No	0	9	5
55	R:R:C126	R:R:C85	7.28	No	No	0	9	9
56	R:R:P86	R:R:Y88	11.13	Yes	Yes	2	8	5
57	R:R:L89	R:R:P86	4.93	Yes	Yes	2	5	8
58	L:L:L32	R:R:Y88	5.86	No	Yes	2	0	5
59	L:L:I29	R:R:L89	4.28	No	Yes	2	0	5
60	R:R:P90	R:R:W91	9.46	Yes	Yes	2	4	4
61	L:L:I29	R:R:P90	5.08	No	Yes	2	0	4
62	R:R:S94	R:R:W91	4.94	No	Yes	0	4	4
63	L:L:K26	R:R:W91	5.8	No	Yes	0	0	4
64	L:L:I29	R:R:W91	8.22	No	Yes	2	0	4
65	R:R:S129	R:R:S94	6.52	No	No	0	1	4
66	R:R:E125	R:R:G98	6.55	No	No	0	5	4
67	R:R:R102	R:R:W110	12	Yes	No	0	8	9
68	R:R:P119	R:R:R102	8.65	No	Yes	0	6	8
69	R:R:F103	R:R:L111	6.09	No	No	8	4	4
70	R:R:F103	R:R:W120	7.02	No	Yes	8	4	5
71	R:R:L109	R:R:Q112	6.65	No	No	0	5	3
72	R:R:L111	R:R:W120	10.25	No	Yes	8	4	5
73	R:R:K113	R:R:S116	6.12	No	No	0	4	5
74	R:R:L123	R:R:R121	6.07	Yes	No	0	5	6
75	R:R:D122	R:R:S124	8.83	No	No	0	7	5
76	R:R:E127	R:R:L123	6.63	No	Yes	0	2	5
77	L:L:V33	R:R:L123	4.47	No	Yes	0	0	5
78	R:R:P137	R:R:S136	5.34	No	No	0	3	1
79	L:L:Y19	R:R:E138	15.71	Yes	No	0	0	2
80	R:R:F381	R:R:Q140	18.74	Yes	No	0	4	4
81	L:L:F12	R:R:L141	4.87	Yes	No	9	0	5
82	L:L:V16	R:R:L141	7.45	No	No	9	0	5
83	R:R:F143	R:R:I147	6.28	No	No	0	4	6
84	R:R:F143	R:R:F385	4.29	No	No	0	4	6
85	R:R:F381	R:R:L144	8.53	Yes	No	0	4	6
86	L:L:F12	R:R:L144	7.31	Yes	No	0	0	6
87	R:R:T149	R:R:Y145	8.74	No	No	0	7	5
88	R:R:D198	R:R:Y145	11.49	No	No	0	7	5
89	R:R:I147	R:R:S389	4.64	No	No	0	6	5
90	R:R:Y148	R:R:Y152	7.94	Yes	Yes	1	7	7
91	R:R:V194	R:R:Y148	12.62	No	Yes	1	7	7
92	R:R:K197	R:R:Y148	7.17	Yes	Yes	1	6	7
93	R:R:L388	R:R:Y148	14.07	No	Yes	0	7	7
94	L:L:E9	R:R:Y148	11.22	Yes	Yes	1	0	7
95	R:R:F393	R:R:G151	9.03	No	No	0	7	8
96	R:R:R190	R:R:Y152	11.32	Yes	Yes	1	8	7
97	R:R:A191	R:R:Y152	5.34	No	Yes	0	7	7
98	R:R:V194	R:R:Y152	10.09	No	Yes	1	7	7
99	R:R:S392	R:R:Y152	7.63	No	Yes	0	9	7
100	L:L:E9	R:R:Y152	10.1	Yes	Yes	1	0	7
101	R:R:F156	R:R:I188	7.54	Yes	No	0	7	7
102	R:R:A191	R:R:F156	4.16	No	Yes	0	7	7
103	R:R:F156	R:R:L192	8.53	Yes	No	0	7	3
104	R:R:F184	R:R:L159	4.87	Yes	Yes	0	8	9
105	R:R:F187	R:R:L159	7.31	Yes	Yes	3	8	9
106	R:R:I188	R:R:L159	4.28	No	Yes	0	7	9
107	R:R:G395	R:R:L159	5.13	No	Yes	3	9	9
108	R:R:F404	R:R:I161	5.02	Yes	No	0	8	4
109	R:R:A162	R:R:F184	4.16	No	Yes	0	9	8
110	R:R:F169	R:R:I165	5.02	Yes	No	4	7	8
111	R:R:C403	R:R:I165	6.55	No	No	0	9	8
112	R:R:F413	R:R:I165	6.28	No	No	4	5	8
113	R:R:L166	R:R:N177	12.36	No	No	0	8	9
114	R:R:L166	R:R:L181	5.54	No	No	0	8	6
115	R:R:F184	R:R:L166	6.09	Yes	No	0	8	8
116	R:R:L167	R:R:L181	8.3	No	No	0	3	6
117	R:R:F169	R:R:L172	6.09	Yes	No	4	7	9
118	R:R:E412	R:R:F169	12.83	Yes	Yes	4	8	7
119	R:R:F169	R:R:F413	12.86	Yes	No	4	7	5
120	R:R:F169	R:R:S416	5.28	Yes	No	0	7	5
121	R:R:H173	R:R:R170	4.51	No	No	0	7	8
122	R:R:E412	R:R:H171	17.23	Yes	No	0	8	7
123	R:R:L172	R:R:V409	4.47	No	No	0	9	9
124	R:R:E412	R:R:L172	6.63	Yes	No	4	8	9
125	R:R:H173	R:R:Y178	10.89	No	No	0	7	6
126	R:R:C174	R:R:R176	5.57	No	No	0	8	9
127	R:R:T175	R:R:Y250	8.74	No	Yes	0	7	8
128	R:R:E262	R:R:T175	9.88	No	No	0	6	7
129	R:R:H180	R:R:R176	6.77	Yes	No	0	9	9
130	R:R:E408	R:R:R176	8.14	No	No	0	9	9
131	R:R:F266	R:R:Y178	4.13	No	No	0	6	6
132	R:R:E247	R:R:I179	6.83	Yes	No	0	9	8
133	R:R:I179	R:R:Y250	8.46	No	Yes	0	8	8
134	R:R:E247	R:R:H180	13.54	Yes	Yes	5	9	9
135	R:R:H180	R:R:L359	5.14	Yes	No	5	9	9
136	R:R:H180	R:R:Y402	4.36	Yes	No	5	9	8
137	R:R:N182	R:R:W243	16.95	No	Yes	10	9	9
138	R:R:N182	R:R:W274	5.65	No	Yes	10	9	9
139	R:R:F187	R:R:L183	7.31	Yes	No	0	8	9
140	R:R:L183	R:R:L244	4.15	No	No	0	9	9
141	R:R:E247	R:R:L183	15.9	Yes	No	0	9	9
142	R:R:N240	R:R:S186	7.45	No	No	0	9	9
143	R:R:S186	R:R:W243	7.41	No	Yes	0	9	9
144	R:R:F187	R:R:N240	16.92	Yes	No	0	8	9
145	R:R:F187	R:R:Q394	11.71	Yes	Yes	3	8	9
146	R:R:F187	R:R:G395	7.53	Yes	No	3	8	9
147	R:R:C236	R:R:L189	9.52	No	No	0	5	7
148	R:R:R190	R:R:V237	10.46	Yes	No	1	8	6
149	R:R:N240	R:R:R190	18.08	No	Yes	0	9	8
150	R:R:R190	R:R:Y241	7.2	Yes	Yes	1	8	8
151	L:L:E9	R:R:R190	13.96	Yes	Yes	1	0	8
152	R:R:L232	R:R:S193	4.5	No	No	0	5	6
153	R:R:C236	R:R:S193	6.89	No	No	0	5	6
154	L:L:E9	R:R:V194	5.7	Yes	No	1	0	7
155	R:R:D198	R:R:K197	9.68	No	Yes	0	7	6
156	R:R:K197	R:R:M233	7.2	Yes	Yes	1	6	6
157	L:L:T13	R:R:K197	10.51	No	Yes	1	0	6
158	R:R:A199	R:R:W203	5.19	No	No	0	3	3
159	R:R:A200	R:R:V229	5.09	No	No	0	4	7
160	R:R:F230	R:R:L201	4.87	No	No	0	5	7
161	L:L:T13	R:R:L201	4.42	No	No	0	0	7
162	R:R:W203	R:R:Y220	10.61	No	No	0	3	3
163	R:R:M204	R:R:Y205	9.58	Yes	Yes	11	3	3
164	R:R:M204	R:R:Q221	9.52	Yes	No	11	3	4
165	R:R:C296	R:R:M204	8.1	No	Yes	0	9	3
166	R:R:M204	R:R:T298	4.52	Yes	No	0	3	5
167	R:R:Q221	R:R:Y205	4.51	No	Yes	11	4	3
168	L:L:S17	R:R:Y205	6.36	No	Yes	0	0	3
169	L:L:L20	R:R:Y205	14.07	No	Yes	0	0	3
170	L:L:E21	R:R:Y205	8.98	No	Yes	0	0	3
171	R:R:Q211	R:R:T207	4.25	No	No	0	4	3
172	R:R:Q210	R:R:W214	4.38	No	Yes	2	4	1
173	L:L:A24	R:R:Q210	6.06	No	No	0	0	4
174	L:L:E27	R:R:Q210	10.19	No	No	2	0	4
175	R:R:Q213	R:R:S219	10.11	Yes	No	0	4	5
176	R:R:Q213	R:R:Q221	10.24	Yes	No	0	4	4
177	L:L:E27	R:R:W214	7.63	No	Yes	2	0	1
178	L:L:F28	R:R:W214	14.03	Yes	Yes	2	0	1
179	L:L:W31	R:R:W214	21.56	No	Yes	0	0	1
180	R:R:C226	R:R:Y220	12.1	No	No	0	9	3
181	R:R:L224	R:R:L228	4.15	No	No	0	3	4
182	R:R:C226	R:R:C296	7.28	No	No	0	9	9
183	R:R:D293	R:R:R227	7.15	No	No	0	7	8
184	R:R:R227	R:R:W297	18.99	No	Yes	0	8	8
185	R:R:F230	R:R:T298	11.67	No	No	0	5	5
186	R:R:L231	R:R:W297	6.83	No	Yes	0	5	8
187	R:R:M233	R:R:Q234	5.44	Yes	Yes	1	6	7
188	L:L:T13	R:R:M233	4.52	No	Yes	1	0	6
189	R:R:Q234	R:R:W284	13.14	Yes	Yes	1	7	8
190	R:R:Q234	R:R:W306	7.67	Yes	Yes	1	7	6
191	R:R:I309	R:R:Q234	9.61	No	Yes	1	7	7
192	L:L:H7	R:R:Q234	9.89	Yes	Yes	1	0	7
193	R:R:A239	R:R:Y235	5.34	No	Yes	0	8	9
194	R:R:W274	R:R:Y235	7.72	Yes	Yes	0	9	9
195	R:R:P277	R:R:Y235	4.17	Yes	Yes	0	9	9
196	R:R:L278	R:R:Y235	5.86	No	Yes	0	3	9
197	R:R:V281	R:R:Y235	5.05	No	Yes	0	6	9
198	L:L:H7	R:R:V237	17.99	Yes	No	1	0	6
199	L:L:E9	R:R:V237	7.13	Yes	No	1	0	6
200	R:R:I313	R:R:Y241	15.71	No	Yes	0	7	8
201	R:R:I317	R:R:Y241	6.04	Yes	Yes	1	7	8
202	R:R:E364	R:R:Y241	13.47	Yes	Yes	1	8	8
203	R:R:L245	R:R:Y242	4.69	No	Yes	0	8	6
204	R:R:V276	R:R:Y242	7.57	No	Yes	0	3	6
205	R:R:P277	R:R:Y242	5.56	Yes	Yes	0	9	6
206	R:R:F280	R:R:Y242	8.25	No	Yes	12	5	6
207	R:R:P312	R:R:Y242	4.17	No	Yes	12	8	6
208	R:R:V246	R:R:W243	9.81	No	Yes	0	8	9
209	R:R:V270	R:R:W243	4.9	No	Yes	0	5	9
210	R:R:G273	R:R:W243	8.44	No	Yes	0	9	9
211	R:R:W243	R:R:W274	25.3	Yes	Yes	10	9	9
212	R:R:L244	R:R:Q394	7.99	No	Yes	0	9	9
213	R:R:A316	R:R:L245	4.73	No	No	0	7	8
214	R:R:V246	R:R:Y269	5.05	No	Yes	0	8	7
215	R:R:E247	R:R:L359	10.6	Yes	No	5	9	9
216	R:R:L254	R:R:Y250	16.41	No	Yes	0	8	8
217	R:R:Y250	R:R:Y269	8.94	Yes	Yes	0	8	7
218	R:R:L251	R:R:L255	4.15	No	No	13	9	8
219	R:R:L251	R:R:V327	5.96	No	No	13	9	9
220	R:R:A256	R:R:Y252	6.67	No	No	0	6	8
221	R:R:T253	R:R:Y269	4.99	No	Yes	0	7	7
222	R:R:L255	R:R:V327	4.47	No	No	13	8	9
223	R:R:Q263	R:R:R267	16.35	No	No	0	5	4
224	R:R:I265	R:R:W264	4.7	No	No	0	5	5
225	R:R:I265	R:R:Y269	13.3	No	Yes	0	5	7
226	R:R:F266	R:R:V270	6.55	No	No	0	6	5
227	R:R:L268	R:R:S271	4.5	No	No	0	2	3
228	R:R:I272	R:R:L268	5.71	No	No	0	6	2
229	R:R:I272	R:R:V276	4.61	No	No	0	6	3
230	R:R:F280	R:R:P312	18.78	No	No	12	5	8
231	R:R:G285	R:R:W284	5.63	No	Yes	0	5	8
232	R:R:K288	R:R:W284	17.4	No	Yes	0	8	8
233	R:R:I309	R:R:W284	16.44	No	Yes	1	7	8
234	R:R:G285	R:R:W297	4.22	No	Yes	0	5	8
235	R:R:V287	R:R:Y305	8.83	No	No	0	4	4
236	R:R:I308	R:R:V287	4.61	No	No	0	8	4
237	R:R:E292	R:R:K288	13.5	Yes	No	0	6	8
238	R:R:K288	R:R:W297	15.08	No	Yes	0	8	8
239	R:R:L290	R:R:Y291	5.86	No	No	0	3	3
240	R:R:Y291	R:R:Y305	8.94	No	No	0	3	4
241	R:R:E292	R:R:E294	7.61	Yes	No	0	6	4
242	R:R:E292	R:R:S301	8.62	Yes	No	0	6	3
243	R:R:G295	R:R:R299	4.5	No	Yes	0	4	4
244	L:L:S17	R:R:T298	7.99	No	No	0	0	5
245	L:L:S17	R:R:R299	10.54	No	Yes	0	0	4
246	L:L:S18	R:R:R299	5.27	No	Yes	0	0	4
247	L:L:E21	R:R:R299	15.12	No	Yes	0	0	4
248	R:R:N300	R:R:W306	30.51	No	Yes	0	6	6
249	L:L:S14	R:R:N300	8.94	No	No	0	0	6
250	R:R:N302	R:R:N304	6.81	No	No	0	5	3
251	R:R:N302	R:R:Y305	18.61	No	No	0	5	4
252	R:R:M303	R:R:R310	4.96	No	Yes	1	5	6
253	R:R:D372	R:R:M303	4.16	Yes	No	1	5	5
254	R:R:E373	R:R:M303	14.89	Yes	No	1	4	5
255	R:R:R310	R:R:W306	24.99	Yes	Yes	1	6	6
256	R:R:D372	R:R:W306	8.93	Yes	Yes	1	5	6
257	L:L:H7	R:R:W306	11.64	Yes	Yes	1	0	6
258	L:L:G10	R:R:W306	4.22	No	Yes	1	0	6
259	R:R:L307	R:R:R310	9.72	No	Yes	0	7	6
260	R:R:L307	R:R:L311	8.3	No	No	0	7	4
261	R:R:M371	R:R:R310	7.44	No	Yes	1	7	6
262	R:R:D372	R:R:R310	15.48	Yes	Yes	1	5	6
263	R:R:E373	R:R:R310	13.96	Yes	Yes	1	4	6
264	L:L:H7	R:R:I313	5.3	Yes	No	0	0	7
265	R:R:F315	R:R:V319	7.87	No	No	0	4	6
266	R:R:E364	R:R:I317	6.83	Yes	Yes	1	8	7
267	R:R:L360	R:R:N320	15.1	No	No	0	9	9
268	R:R:F321	R:R:V325	6.55	No	No	0	6	5
269	R:R:F321	R:R:V365	13.11	No	No	0	6	6
270	R:R:F324	R:R:I328	6.28	No	No	0	9	7
271	R:R:F324	R:R:L356	8.53	No	No	0	9	9
272	R:R:F324	R:R:T362	14.27	No	No	0	9	7
273	R:R:I330	R:R:R326	10.02	No	No	0	9	8
274	R:R:I328	R:R:T353	4.56	No	No	0	7	9
275	R:R:S352	R:R:V331	6.46	No	No	0	9	8
276	R:R:K336	R:R:V332	4.55	No	No	0	6	6
277	R:R:L349	R:R:V332	4.47	No	No	0	9	6
278	R:R:I345	R:R:L335	5.71	No	No	0	5	8
279	R:R:C347	W:W:?1	39.17	No	Yes	0	7	0
280	R:R:K351	R:R:R348	9.9	No	No	0	8	8
281	R:R:A350	W:W:?1	13.89	No	Yes	0	8	0
282	R:R:L401	R:R:T355	5.9	No	No	0	8	8
283	R:R:L356	R:R:L360	6.92	No	No	0	9	9
284	R:R:I357	R:R:T362	6.08	No	No	0	8	7
285	R:R:L401	R:R:P358	4.93	No	No	0	8	9
286	R:R:L359	R:R:Y402	23.45	No	No	5	9	8
287	R:R:L360	R:R:T362	4.42	No	No	0	9	7
288	R:R:G361	R:R:H363	4.77	No	No	3	9	8
289	R:R:G361	R:R:Q394	4.93	No	Yes	3	9	9
290	R:R:F390	R:R:H363	10.18	No	No	0	6	8
291	R:R:H363	R:R:Q394	9.89	No	Yes	3	8	9
292	R:R:E364	R:R:E387	16.49	Yes	No	0	8	8
293	R:R:E364	R:R:T391	4.23	Yes	No	0	8	6
294	R:R:F367	R:R:I366	10.05	No	No	0	7	6
295	R:R:F367	R:R:K383	7.44	No	Yes	0	7	7
296	R:R:F367	R:R:T386	9.08	No	No	0	7	4
297	R:R:A368	R:R:F369	5.55	No	No	0	6	4
298	R:R:L379	R:R:V370	4.47	No	No	0	3	5
299	R:R:E373	R:R:M371	5.41	Yes	No	1	4	7
300	R:R:D372	R:R:E373	6.5	Yes	Yes	1	5	4
301	L:L:T11	R:R:D372	7.23	Yes	Yes	0	0	5
302	R:R:E373	R:R:H374	6.15	Yes	No	0	4	3
303	L:L:T11	R:R:R380	5.17	Yes	No	0	0	5
304	L:L:D15	R:R:R380	11.91	No	No	0	0	5
305	R:R:F381	R:R:F385	4.29	Yes	No	0	4	6
306	R:R:E387	R:R:K383	8.1	No	Yes	0	8	7
307	L:L:T11	R:R:K383	4.5	Yes	Yes	0	0	7
308	L:L:T11	R:R:L384	5.9	Yes	No	0	0	5
309	R:R:F385	R:R:S389	7.93	No	No	0	6	5
310	L:L:A8	R:R:E387	6.03	No	No	0	0	8
311	L:L:F12	R:R:L388	6.09	Yes	No	0	0	7
312	R:R:I400	R:R:L396	4.28	No	No	0	6	7
313	R:R:L401	R:R:Y402	4.69	No	No	0	8	8
314	R:R:C403	R:R:F404	6.98	No	Yes	0	9	8
315	R:R:N406	R:R:V409	5.91	No	No	0	9	9
316	R:R:E412	R:R:K415	10.8	Yes	No	0	8	7
317	R:R:W417	R:R:W420	6.56	No	No	0	5	4
318	L:L:G10	L:L:H7	4.77	No	Yes	1	0	0
319	L:L:F12	L:L:V16	7.87	Yes	No	9	0	0
320	L:L:Q23	L:L:Y19	16.91	No	Yes	0	0	0
321	L:L:F28	L:L:L32	13.4	Yes	No	2	0	0
322	L:L:R36	L:L:W31	14.99	Yes	No	0	0	0
323	R:R:D222	R:R:L218	4.07	No	No	0	6	3
324	R:R:F184	R:R:S163	3.96	Yes	No	0	8	6
325	R:R:F393	R:R:S392	3.96	No	No	0	7	9
326	R:R:R419	R:R:S416	3.95	No	No	0	7	5
327	R:R:E292	R:R:N302	3.94	Yes	No	0	6	5
328	R:R:E408	R:R:N406	3.94	No	No	0	9	9
329	R:R:F156	R:R:V160	3.93	Yes	No	0	7	3
330	R:R:F184	R:R:V398	3.93	Yes	No	0	8	9
331	R:R:F230	R:R:V229	3.93	No	No	0	5	7
332	R:R:R102	R:R:T65	3.88	Yes	No	0	8	5
333	R:R:H212	R:R:L217	3.86	No	No	0	3	4
334	L:L:Y19	R:R:S136	3.82	Yes	No	0	0	1
335	R:R:S155	R:R:Y152	3.82	No	Yes	0	9	7
336	R:R:V249	R:R:Y269	3.79	No	Yes	0	6	7
337	R:R:F381	R:R:I382	3.77	Yes	No	0	4	4
338	R:R:F404	R:R:I400	3.77	Yes	No	0	8	6
339	L:L:A25	R:R:P90	3.74	No	Yes	0	0	4
340	R:R:A238	R:R:P277	3.74	No	Yes	0	6	9
341	R:R:S261	R:R:W264	3.71	No	No	0	7	5
342	R:R:V100	R:R:W72	3.68	No	Yes	0	7	9
343	R:R:F369	R:R:L314	3.65	No	No	0	4	4
344	L:L:R36	R:R:D215	3.57	Yes	No	0	0	3
345	R:R:P90	R:R:V30	3.53	Yes	No	0	4	2
346	R:R:G248	R:R:I323	3.53	No	No	0	8	8
347	R:R:P283	R:R:V282	3.53	No	No	0	5	3
348	R:R:G318	R:R:I317	3.53	No	Yes	0	4	7
349	L:L:Y19	R:R:L141	3.52	Yes	No	0	0	5
350	L:L:L20	L:L:Y19	3.52	No	Yes	0	0	0
351	R:R:P56	R:R:T58	3.5	No	No	0	1	1
352	R:R:K113	R:R:W120	3.48	No	Yes	0	4	5
353	R:R:C126	R:R:V100	3.42	No	No	0	9	7
354	R:R:G248	R:R:N320	3.39	No	No	0	8	9
355	R:R:I357	R:R:P358	3.39	No	No	0	8	9
356	R:R:E125	R:R:Y101	3.37	No	Yes	0	5	5
357	R:R:M397	R:R:P358	3.35	No	No	0	5	9
358	R:R:Q213	R:R:W33	3.29	Yes	No	0	4	3
359	R:R:Q211	R:R:W214	3.29	No	Yes	0	4	1
360	R:R:L118	R:R:P119	3.28	No	No	0	4	6
361	R:R:H99	R:R:Y101	3.27	No	Yes	0	4	5
362	R:R:A368	R:R:I317	3.25	No	Yes	0	6	7
363	R:R:A375	R:R:K383	3.21	No	Yes	0	4	7
364	L:L:S18	R:R:T29	3.2	No	No	0	0	2
365	R:R:P119	R:R:Q112	3.16	No	No	0	6	3
366	R:R:A399	R:R:L159	3.15	No	Yes	0	8	9
367	R:R:A375	R:R:L379	3.15	No	No	0	4	3
368	R:R:F195	R:R:Y152	3.09	No	Yes	0	7	7
369	R:R:R326	R:R:Y252	3.09	No	No	0	8	8
370	R:R:M233	R:R:S193	3.07	Yes	No	0	6	6
371	R:R:I196	R:R:V229	3.07	No	No	0	5	7
372	R:R:I286	R:R:V282	3.07	No	No	0	4	3
373	R:R:I317	R:R:V365	3.07	Yes	No	0	7	6
374	R:R:I400	R:R:V405	3.07	No	No	0	6	6
375	R:R:L118	R:R:S117	3	No	No	0	4	7
376	R:R:L260	R:R:S258	3	No	No	0	7	7
377	R:R:L154	R:R:V150	2.98	No	No	0	5	5
378	R:R:L245	R:R:V319	2.98	No	No	0	8	6
379	R:R:L278	R:R:V282	2.98	No	No	0	3	3
380	R:R:L356	R:R:V327	2.98	No	No	0	9	9
381	R:R:L335	R:R:V331	2.98	No	No	0	8	8
382	R:R:L111	R:R:T105	2.95	No	No	0	4	4
383	R:R:L349	R:R:T353	2.95	No	No	0	9	9
384	R:R:I146	R:R:I147	2.94	No	No	0	4	6
385	R:R:I330	R:R:K334	2.91	No	No	0	9	9
386	R:R:W297	R:R:Y289	2.89	Yes	No	0	8	3
387	R:R:E34	R:R:S31	2.87	No	No	0	4	4
388	R:R:I146	R:R:L142	2.85	No	No	0	4	3
389	R:R:I330	R:R:L255	2.85	No	No	0	9	8
390	R:R:I265	R:R:L260	2.85	No	No	0	5	7
391	R:R:E107	R:R:T105	2.82	No	No	0	5	4
392	R:R:G216	R:R:W33	2.81	No	No	0	2	3
393	R:R:H99	R:R:S84	2.79	No	No	0	4	4
394	R:R:L154	R:R:L396	2.77	No	No	0	5	7
395	R:R:A158	R:R:F404	2.77	No	Yes	0	7	8
396	R:R:L228	R:R:L231	2.77	No	No	0	4	5
397	R:R:L335	R:R:L349	2.77	No	No	0	8	9
398	R:R:E418	R:R:K415	2.7	No	No	0	4	7
399	R:R:N407	R:R:Q410	2.64	No	No	0	6	7
400	R:R:A185	R:R:W274	2.59	No	Yes	0	3	9
401	R:R:E41	R:R:Q45	2.55	No	No	0	4	5
402	R:R:K346	W:W:?1	2.49	No	Yes	0	6	0
403	R:R:K351	W:W:?1	2.49	No	Yes	0	8	0
404	R:R:N63	R:R:R64	2.41	No	Yes	0	4	4
405	R:R:Q45	R:R:R48	2.34	No	No	0	5	4
406	R:R:Q45	R:R:W87	2.19	No	No	0	5	3
407	R:R:R376	R:R:R380	2.13	No	No	0	5	5
408	R:R:G108	R:R:P77	2.03	No	No	0	9	4
409	R:R:G275	R:R:P277	2.03	No	Yes	0	6	9
410	R:R:C85	R:R:G98	1.96	No	No	0	9	4
411	R:R:C104	R:R:G108	1.96	No	No	0	9	9
412	R:R:P54	R:R:P55	1.95	No	No	0	2	1
413	L:L:G22	R:R:T29	1.82	No	No	0	0	2
414	R:R:P73	R:R:V83	1.77	No	No	0	5	5
415	L:L:G35	L:L:K34	1.74	No	No	0	0	0
416	R:R:C226	R:R:S223	1.72	No	No	0	9	4
417	R:R:A208	R:R:S206	1.71	No	No	0	4	4
418	R:R:A209	R:R:S206	1.71	No	No	0	1	4
419	R:R:A209	R:R:S219	1.71	No	No	0	1	5
420	R:R:C329	R:R:V325	1.71	No	No	0	7	5
421	R:R:D74	R:R:G75	1.68	Yes	No	0	3	7
422	R:R:S223	R:R:S225	1.63	No	No	0	4	3
423	R:R:A92	R:R:L89	1.58	No	Yes	0	5	5
424	R:R:K38	R:R:V30	1.52	No	No	0	4	2
425	R:R:I382	R:R:T378	1.52	No	No	0	4	2
426	R:R:K351	R:R:T355	1.5	No	No	0	8	8
427	R:R:G377	R:R:R376	1.5	No	No	0	4	5
428	R:R:D222	R:R:S219	1.47	No	No	0	6	5
429	R:R:A208	R:R:H212	1.46	No	No	0	4	3
430	R:R:Q263	R:R:S261	1.44	No	No	0	5	7
431	R:R:I357	R:R:L354	1.43	No	No	0	8	8
432	R:R:Q410	R:R:V405	1.43	No	No	0	7	6
433	R:R:L411	R:R:R414	1.21	No	No	0	4	6
434	R:R:E418	R:R:R414	1.16	No	No	0	4	6
435	R:R:D122	R:R:W120	1.12	No	Yes	0	7	5
436	R:R:E423	R:R:W420	1.09	No	No	0	4	4
437	R:R:R421	R:R:W420	1	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:W39	11.5283	6	2	5
2	R:R:Y42	10.09	4	2	6
3	R:R:R64	9.466	5	0	4
4	R:R:W72	9.58667	6	7	9
5	R:R:D74	10.2875	4	6	3
6	R:R:P86	7.84	4	2	8
7	R:R:Y88	12.0425	4	2	5
8	R:R:L89	3.87	4	2	5
9	R:R:P90	5.412	5	2	4
10	R:R:W91	7.105	4	2	4
11	R:R:Y101	4.9525	4	0	5
12	R:R:R102	10.134	5	7	8
13	R:R:W120	5.4675	4	8	5
14	R:R:L123	6.93	4	0	5
15	R:R:Y148	10.604	5	1	7
16	R:R:Y152	7.41625	8	1	7
17	R:R:F156	6.04	4	0	7
18	R:R:L159	4.948	5	3	9
19	R:R:F169	8.416	5	4	7
20	R:R:H180	7.4525	4	5	9
21	R:R:F184	4.602	5	0	8
22	R:R:F187	10.156	5	3	8
23	R:R:R190	12.204	5	1	8
24	R:R:K197	8.64	4	1	6
25	R:R:M204	7.93	4	11	3
26	R:R:Y205	8.7	5	11	3
27	R:R:Q213	8.5725	4	0	4
28	R:R:W214	9.43	6	2	1
29	R:R:M233	5.0575	4	1	6
30	R:R:Q234	9.15	5	1	7
31	R:R:Y235	5.628	5	0	9
32	R:R:Y241	10.605	4	1	8
33	R:R:Y242	6.048	5	12	6
34	R:R:W243	12.135	6	10	9
35	R:R:E247	11.7175	4	5	9
36	R:R:Y250	10.6375	4	0	8
37	R:R:Y269	7.214	5	0	7
38	R:R:W274	10.315	4	10	9
39	R:R:P277	3.875	4	0	9
40	R:R:W284	13.1525	4	1	8
41	R:R:E292	8.4175	4	0	6
42	R:R:W297	9.602	5	0	8
43	R:R:R299	8.8575	4	0	4
44	R:R:W306	14.66	6	1	6
45	R:R:R310	12.7583	6	1	6
46	R:R:I317	4.544	5	1	7
47	R:R:E364	10.255	4	1	8
48	R:R:D372	8.46	5	1	5
49	R:R:E373	9.382	5	1	4
50	R:R:F381	8.8325	4	0	4
51	R:R:K383	5.8125	4	0	7
52	R:R:Q394	8.63	4	3	9
53	R:R:F404	4.635	4	0	8
54	R:R:E412	11.8725	4	4	8
55	W:W:?1	14.51	4	0	0
56	L:L:H7	9.918	5	1	0
57	L:L:E9	9.622	5	1	0
58	L:L:T11	5.7	4	0	0
59	L:L:F12	6.535	4	9	0
60	L:L:Y19	8.696	5	0	0
61	L:L:F28	11.485	4	2	0
62	L:L:R36	10.5875	4	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q221	R:R:Y205	47.184	4.51	No	Yes	11	4	3
2	R:R:Q213	R:R:Q221	100	10.24	Yes	No	0	4	4
3	R:R:L32	R:R:Q213	94.0794	10.65	No	Yes	0	4	4
4	R:R:L32	R:R:W214	92.6958	5.69	No	Yes	0	4	1
5	L:L:F28	R:R:W214	87.4668	14.03	Yes	Yes	2	0	1
6	L:L:F28	R:R:W39	45.1217	8.02	Yes	Yes	2	0	5
7	R:R:W39	R:R:Y88	41.2634	20.26	Yes	Yes	2	5	5
8	R:R:P86	R:R:Y88	74.8963	11.13	Yes	Yes	2	8	5
9	R:R:L89	R:R:P86	12.7163	4.93	Yes	Yes	2	5	8
10	L:L:I29	R:R:L89	10.8953	4.28	No	Yes	2	0	5
11	L:L:F28	L:L:L32	41.458	13.4	Yes	No	2	0	0
12	L:L:L32	R:R:Y88	40.9709	5.86	No	Yes	2	0	5
13	R:R:P86	R:R:Y69	61.4322	9.74	Yes	No	2	8	6
14	R:R:L123	R:R:Y69	60.7456	10.55	Yes	No	0	5	6
15	R:R:L123	R:R:R121	57.6385	6.07	Yes	No	0	5	6
16	R:R:D67	R:R:R121	56.5957	10.72	No	No	0	9	6
17	R:R:D67	R:R:W72	39.5355	10.05	No	Yes	7	9	9
18	R:R:V83	R:R:W72	15.2258	13.48	No	Yes	0	5	9
19	R:R:P73	R:R:V83	14.1447	1.77	No	No	0	5	5
20	R:R:P73	R:R:R64	13.0626	4.32	No	Yes	0	5	4
21	R:R:D67	R:R:R102	16.0288	7.15	No	Yes	7	9	8
22	R:R:V100	R:R:W72	21.6902	3.68	No	Yes	0	7	9
23	R:R:C126	R:R:V100	20.6165	3.42	No	No	0	9	7
24	R:R:C126	R:R:C85	19.5404	7.28	No	No	0	9	9
25	R:R:C85	R:R:G98	17.3851	1.96	No	No	0	9	4
26	R:R:E125	R:R:G98	16.306	6.55	No	No	0	5	4
27	R:R:E125	R:R:Y101	15.2258	3.37	No	Yes	0	5	5
28	R:R:F80	R:R:Y101	10.8953	6.19	No	Yes	0	4	5
29	L:L:L20	R:R:Y205	46.9969	14.07	No	Yes	0	0	3
30	L:L:L20	L:L:Y19	47.1084	3.52	No	Yes	0	0	0
31	L:L:Y19	R:R:L141	47.9268	3.52	Yes	No	0	0	5
32	L:L:F12	R:R:L141	47.9716	4.87	Yes	No	9	0	5
33	R:R:M204	R:R:T298	54.825	4.52	Yes	No	0	3	5
34	R:R:F230	R:R:T298	56.8644	11.67	No	No	0	5	5
35	R:R:F230	R:R:L201	57.4853	4.87	No	No	0	5	7
36	L:L:T13	R:R:L201	57.6405	4.42	No	No	0	0	7
37	L:L:T13	R:R:K197	48.5398	10.51	No	Yes	1	0	6
38	L:L:F12	R:R:L388	50.6403	6.09	Yes	No	0	0	7
39	R:R:L388	R:R:Y148	50.7931	14.07	No	Yes	0	7	7
40	R:R:Y148	R:R:Y152	52.0428	7.94	Yes	Yes	1	7	7
41	L:L:E9	R:R:Y148	47.9054	11.22	Yes	Yes	1	0	7
42	R:R:R190	R:R:Y152	48.4631	11.32	Yes	Yes	1	8	7
43	L:L:E9	R:R:R190	47.39	13.96	Yes	Yes	1	0	8
44	R:R:N240	R:R:R190	96.9118	18.08	No	Yes	0	9	8
45	R:R:F187	R:R:N240	75.5236	16.92	Yes	No	0	8	9
46	R:R:F187	R:R:L183	68.0488	7.31	Yes	No	0	8	9
47	R:R:E247	R:R:L183	67.4149	15.9	Yes	No	0	9	9
48	R:R:E247	R:R:H180	41.2545	13.54	Yes	Yes	5	9	9
49	R:R:H180	R:R:R176	16.0597	6.77	Yes	No	0	9	9
50	R:R:E408	R:R:R176	14.9373	8.14	No	No	0	9	9
51	R:R:E408	R:R:N406	14.3765	3.94	No	No	0	9	9
52	R:R:N406	R:R:V409	13.8128	5.91	No	No	0	9	9
53	R:R:L172	R:R:V409	13.2482	4.47	No	No	0	9	9
54	R:R:N240	R:R:S186	25.86	7.45	No	No	0	9	9
55	R:R:S186	R:R:W243	25.3117	7.41	No	Yes	0	9	9
56	R:R:E247	R:R:L359	25.862	10.6	Yes	No	5	9	9
57	R:R:H180	R:R:Y402	25.9754	4.36	Yes	No	5	9	8
58	R:R:L359	R:R:Y402	25.3346	23.45	No	No	5	9	8
59	R:R:W243	R:R:W274	14.8164	25.3	Yes	Yes	10	9	9
60	R:R:M233	R:R:Q234	10.271	5.44	Yes	Yes	1	6	7
61	R:R:W274	R:R:Y235	13.5596	7.72	Yes	Yes	0	9	9
62	R:R:L401	R:R:Y402	50.2174	4.69	No	No	0	8	8
63	R:R:L401	R:R:P358	41.4371	4.93	No	No	0	8	9
64	R:R:I357	R:R:P358	39.232	3.39	No	No	0	8	9
65	R:R:I357	R:R:T362	37.023	6.08	No	No	0	8	7
66	R:R:F324	R:R:T362	21.3454	14.27	No	No	0	9	7
67	R:R:F324	R:R:L356	10.166	8.53	No	No	0	9	9
68	R:R:L356	R:R:V327	18.018	2.98	No	No	0	9	9
69	R:R:L360	R:R:T362	14.6109	4.42	No	No	0	9	7
70	R:R:L356	R:R:L360	10.1391	6.92	No	No	0	9	9
71	R:R:L255	R:R:V327	13.5163	4.47	No	No	13	8	9
72	R:R:I330	R:R:L255	11.2685	2.85	No	No	0	9	8
73	R:R:F324	R:R:I328	10.1819	6.28	No	No	0	9	7
74	R:R:M204	R:R:Q221	53.2309	9.52	Yes	No	11	3	4
75	R:R:K197	R:R:Y148	50.8965	7.17	Yes	Yes	1	6	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:E21	R:R:S31	4.31	0	No	No	0	4	0	1
R:R:L32	R:R:Q213	10.65	0	No	Yes	4	4	1	2
R:R:L32	R:R:W214	5.69	0	No	Yes	4	1	1	1
L:L:A24	R:R:L32	4.73	0	No	No	0	4	0	1
R:R:P90	R:R:T35	5.25	2	Yes	No	4	5	1	2
L:L:F28	R:R:V36	10.49	2	Yes	No	0	2	0	1
R:R:R43	R:R:W39	13	0	No	Yes	4	5	2	1
R:R:E68	R:R:W39	4.36	2	No	Yes	4	5	1	1
R:R:W39	R:R:Y88	20.26	2	Yes	Yes	5	5	1	1
L:L:F28	R:R:W39	8.02	2	Yes	Yes	0	5	0	1
L:L:L32	R:R:W39	12.53	2	No	Yes	0	5	0	1
L:L:R36	R:R:W39	11	2	Yes	Yes	0	5	0	1
R:R:P86	R:R:Y42	5.56	2	Yes	Yes	8	6	2	2
R:R:Y42	R:R:Y88	10.92	2	Yes	Yes	6	5	2	1
R:R:F66	R:R:R43	5.34	0	No	No	7	4	2	2
R:R:E68	R:R:F66	4.66	2	No	No	4	7	1	2
L:L:R36	R:R:E68	12.79	2	Yes	No	0	4	0	1
R:R:P86	R:R:Y69	9.74	2	Yes	No	8	6	2	2
R:R:L89	R:R:Y69	4.69	2	Yes	No	5	6	1	2
R:R:L123	R:R:Y69	10.55	0	Yes	No	5	6	1	2
R:R:P86	R:R:Y88	11.13	2	Yes	Yes	8	5	2	1
R:R:L89	R:R:P86	4.93	2	Yes	Yes	5	8	1	2
L:L:L32	R:R:Y88	5.86	2	No	Yes	0	5	0	1
L:L:I29	R:R:L89	4.28	2	No	Yes	0	5	0	1
R:R:P90	R:R:W91	9.46	2	Yes	Yes	4	4	1	1
L:L:I29	R:R:P90	5.08	2	No	Yes	0	4	0	1
R:R:S94	R:R:W91	4.94	0	No	Yes	4	4	2	1
L:L:K26	R:R:W91	5.8	0	No	Yes	0	4	0	1
L:L:I29	R:R:W91	8.22	2	No	Yes	0	4	0	1
R:R:L123	R:R:R121	6.07	0	Yes	No	5	6	1	2
R:R:E127	R:R:L123	6.63	0	No	Yes	2	5	2	1
L:L:V33	R:R:L123	4.47	0	No	Yes	0	5	0	1
R:R:P137	R:R:S136	5.34	0	No	No	3	1	2	1
L:L:Y19	R:R:E138	15.71	0	Yes	No	0	2	0	1
L:L:F12	R:R:L141	4.87	9	Yes	No	0	5	0	1
L:L:V16	R:R:L141	7.45	9	No	No	0	5	0	1
R:R:F381	R:R:L144	8.53	0	Yes	No	4	6	2	1
L:L:F12	R:R:L144	7.31	9	Yes	No	0	6	0	1
R:R:Y148	R:R:Y152	7.94	1	Yes	Yes	7	7	1	1
R:R:V194	R:R:Y148	12.62	1	No	Yes	7	7	1	1
R:R:K197	R:R:Y148	7.17	1	Yes	Yes	6	7	1	1
R:R:L388	R:R:Y148	14.07	0	No	Yes	7	7	1	1
L:L:E9	R:R:Y148	11.22	1	Yes	Yes	0	7	0	1
R:R:R190	R:R:Y152	11.32	1	Yes	Yes	8	7	1	1
R:R:A191	R:R:Y152	5.34	0	No	Yes	7	7	2	1
R:R:V194	R:R:Y152	10.09	1	No	Yes	7	7	1	1
R:R:S392	R:R:Y152	7.63	0	No	Yes	9	7	2	1
L:L:E9	R:R:Y152	10.1	1	Yes	Yes	0	7	0	1
R:R:R190	R:R:V237	10.46	1	Yes	No	8	6	1	1
R:R:N240	R:R:R190	18.08	0	No	Yes	9	8	2	1
R:R:R190	R:R:Y241	7.2	1	Yes	Yes	8	8	1	2
L:L:E9	R:R:R190	13.96	1	Yes	Yes	0	8	0	1
L:L:E9	R:R:V194	5.7	1	Yes	No	0	7	0	1
R:R:D198	R:R:K197	9.68	0	No	Yes	7	6	2	1
R:R:K197	R:R:M233	7.2	1	Yes	Yes	6	6	1	1
L:L:T13	R:R:K197	10.51	1	No	Yes	0	6	0	1
R:R:F230	R:R:L201	4.87	0	No	No	5	7	2	1
L:L:T13	R:R:L201	4.42	1	No	No	0	7	0	1
R:R:M204	R:R:Y205	9.58	11	Yes	Yes	3	3	2	1
R:R:M204	R:R:Q221	9.52	11	Yes	No	3	4	2	2
R:R:M204	R:R:T298	4.52	11	Yes	No	3	5	2	1
R:R:Q221	R:R:Y205	4.51	11	No	Yes	4	3	2	1
L:L:S17	R:R:Y205	6.36	0	No	Yes	0	3	0	1
L:L:L20	R:R:Y205	14.07	0	No	Yes	0	3	0	1
L:L:E21	R:R:Y205	8.98	0	No	Yes	0	3	0	1
R:R:Q210	R:R:W214	4.38	2	No	Yes	4	1	1	1
L:L:A24	R:R:Q210	6.06	0	No	No	0	4	0	1
L:L:E27	R:R:Q210	10.19	2	No	No	0	4	0	1
R:R:Q213	R:R:Q221	10.24	0	Yes	No	4	4	2	2
L:L:E27	R:R:W214	7.63	2	No	Yes	0	1	0	1
L:L:F28	R:R:W214	14.03	2	Yes	Yes	0	1	0	1
L:L:W31	R:R:W214	21.56	0	No	Yes	0	1	0	1
R:R:F230	R:R:T298	11.67	0	No	No	5	5	2	1
R:R:M233	R:R:Q234	5.44	1	Yes	Yes	6	7	1	1
L:L:T13	R:R:M233	4.52	1	No	Yes	0	6	0	1
R:R:Q234	R:R:W284	13.14	1	Yes	Yes	7	8	1	2
R:R:Q234	R:R:W306	7.67	1	Yes	Yes	7	6	1	1
R:R:I309	R:R:Q234	9.61	1	No	Yes	7	7	2	1
L:L:H7	R:R:Q234	9.89	1	Yes	Yes	0	7	0	1
L:L:H7	R:R:V237	17.99	1	Yes	No	0	6	0	1
L:L:E9	R:R:V237	7.13	1	Yes	No	0	6	0	1
R:R:I313	R:R:Y241	15.71	0	No	Yes	7	8	1	2
R:R:E364	R:R:Y241	13.47	1	Yes	Yes	8	8	2	2
R:R:I309	R:R:W284	16.44	1	No	Yes	7	8	2	2
R:R:G295	R:R:R299	4.5	0	No	Yes	4	4	2	1
L:L:S17	R:R:T298	7.99	0	No	No	0	5	0	1
L:L:S17	R:R:R299	10.54	0	No	Yes	0	4	0	1
L:L:S18	R:R:R299	5.27	0	No	Yes	0	4	0	1
L:L:E21	R:R:R299	15.12	0	No	Yes	0	4	0	1
R:R:N300	R:R:W306	30.51	0	No	Yes	6	6	1	1
L:L:S14	R:R:N300	8.94	0	No	No	0	6	0	1
R:R:M303	R:R:R310	4.96	1	No	Yes	5	6	2	2
R:R:D372	R:R:M303	4.16	1	Yes	No	5	5	1	2
R:R:E373	R:R:M303	14.89	1	Yes	No	4	5	2	2
R:R:R310	R:R:W306	24.99	1	Yes	Yes	6	6	2	1
R:R:D372	R:R:W306	8.93	1	Yes	Yes	5	6	1	1
L:L:H7	R:R:W306	11.64	1	Yes	Yes	0	6	0	1
L:L:G10	R:R:W306	4.22	1	No	Yes	0	6	0	1
R:R:D372	R:R:R310	15.48	1	Yes	Yes	5	6	1	2
R:R:E373	R:R:R310	13.96	1	Yes	Yes	4	6	2	2
L:L:H7	R:R:I313	5.3	1	Yes	No	0	7	0	1
R:R:E364	R:R:E387	16.49	1	Yes	No	8	8	2	1
R:R:F367	R:R:K383	7.44	0	No	Yes	7	7	2	1
R:R:D372	R:R:E373	6.5	1	Yes	Yes	5	4	1	2
L:L:T11	R:R:D372	7.23	0	Yes	Yes	0	5	0	1
L:L:T11	R:R:R380	5.17	0	Yes	No	0	5	0	1
L:L:D15	R:R:R380	11.91	0	No	No	0	5	0	1
R:R:E387	R:R:K383	8.1	0	No	Yes	8	7	1	1
L:L:T11	R:R:K383	4.5	0	Yes	Yes	0	7	0	1
L:L:T11	R:R:L384	5.9	0	Yes	No	0	5	0	1
L:L:A8	R:R:E387	6.03	0	No	No	0	8	0	1
L:L:F12	R:R:L388	6.09	9	Yes	No	0	7	0	1
L:L:Y19	R:R:S136	3.82	0	Yes	No	0	1	0	1
R:R:S155	R:R:Y152	3.82	0	No	Yes	9	7	2	1
L:L:A25	R:R:P90	3.74	0	No	Yes	0	4	0	1
L:L:R36	R:R:D215	3.57	2	Yes	No	0	3	0	1
R:R:P90	R:R:V30	3.53	2	Yes	No	4	2	1	2
L:L:Y19	R:R:L141	3.52	0	Yes	No	0	5	0	1
R:R:Q211	R:R:W214	3.29	0	No	Yes	4	1	2	1
R:R:A375	R:R:K383	3.21	0	No	Yes	4	7	2	1
L:L:S18	R:R:T29	3.2	0	No	No	0	2	0	1
R:R:F195	R:R:Y152	3.09	0	No	Yes	7	7	2	1
R:R:M233	R:R:S193	3.07	1	Yes	No	6	6	1	2
R:R:E34	R:R:S31	2.87	0	No	No	4	4	2	1
R:R:R376	R:R:R380	2.13	0	No	No	5	5	2	1
L:L:G22	R:R:T29	1.82	0	No	No	0	2	0	1
R:R:A92	R:R:L89	1.58	0	No	Yes	5	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:C347	W:W:?1	39.17	No	Yes	7	0	1	0
R:R:K351	R:R:R348	9.9	No	No	8	8	1	2
R:R:A350	W:W:?1	13.89	No	Yes	8	0	1	0
R:R:K346	W:W:?1	2.49	No	Yes	6	0	1	0
R:R:K351	W:W:?1	2.49	No	Yes	8	0	1	0
R:R:K351	R:R:T355	1.5	No	No	8	8	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7DUQ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.12
Number of Linked Nodes	389
Number of Links	437
Number of Hubs	62
Number of Links mediated by Hubs	240
Number of Communities	13
Number of Nodes involved in Communities	78
Number of Links involved in Communities	102

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	285773
Length Of Smallest Path	3
Average Path Length	25.9745
Length of Longest Path	51
Minimum Path Strength	1.045
Average Path Strength	8.91274
Maximum Path Strength	27.75
Minimum Path Correlation	0.7
Average Path Correlation	0.95383
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	48.7021
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.547
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• monosaccharide metabolic process • regulation of cellular process • positive regulation of biological process • gluconeogenesis • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • small molecule metabolic process • regulation of carbohydrate metabolic process • regulation of glucose metabolic process • positive regulation of cellular process • positive regulation of gluconeogenesis • regulation of biosynthetic process • carbohydrate metabolic process • regulation of biological process • small molecule biosynthetic process • carbohydrate biosynthetic process • biological regulation • hexose metabolic process • primary metabolic process • monosaccharide biosynthetic process • hexose biosynthetic process • positive regulation of glucose metabolic process • biosynthetic process • regulation of gluconeogenesis • metabolic process • cellular process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • glucose metabolic process • cellular response to stimulus • positive regulation of cell communication • positive regulation of signal transduction • response to stimulus • signaling • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of programmed cell death • regulation of apoptotic process • negative regulation of biological process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of cellular process • apoptotic process • programmed cell death • cellular response to nitrogen compound • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular response to hormone stimulus • response to activity • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • protein kinase A signaling • negative regulation of execution phase of apoptosis • regulation of execution phase of apoptosis • execution phase of apoptosis • behavior • multicellular organismal process • feeding behavior • adenylate cyclase-activating G protein-coupled receptor signaling pathway • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of biological quality • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • positive regulation of establishment of protein localization • carbohydrate homeostasis • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • positive regulation of peptide hormone secretion • intracellular glucose homeostasis • cellular response to carbohydrate stimulus • chemical homeostasis • response to glucose • glucose homeostasis • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • homeostatic process • positive regulation of secretion by cell • positive regulation of protein transport • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • positive regulation of peptide secretion • cellular response to glucose stimulus • positive regulation of protein secretion • response to hexose • cellular homeostasis • positive regulation of transport • regulation of insulin secretion involved in cellular response to glucose stimulus • regulation of calcium ion import • regulation of calcium ion transport • positive regulation of calcium ion transport • positive regulation of calcium ion import • regulation of monoatomic ion transport • calcium ion transport • metal ion transport • positive regulation of monoatomic ion transport • monoatomic ion transport • calcium ion import • monoatomic cation transport • regulation of metal ion transport • cell periphery • cellular anatomical structure • plasma membrane • membrane • membrane-bounded organelle • intracellular anatomical structure • membrane-enclosed lumen • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle lumen • endoplasmic reticulum lumen • intracellular organelle • organelle lumen • organelle
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • plasma membrane • membrane • membrane-bounded organelle • intracellular anatomical structure • membrane-enclosed lumen • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle lumen • endoplasmic reticulum lumen • intracellular organelle • organelle lumen • organelle • endoplasmic reticulum • cytoplasm • extracellular region • vesicle lumen • intracellular vesicle • cytoplasmic vesicle lumen • secretory granule lumen • cytoplasmic vesicle • secretory granule • secretory vesicle • vesicle • extracellular space • glucagon receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • amide binding • binding • peptide hormone binding • hormone binding • glucagon-like peptide 1 receptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • heart process • multicellular organismal process • system process • regulation of biological process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • regulation of blood pressure • positive regulation of blood pressure • cellular response to stimulus • regulation of cellular process • response to stimulus • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to stress • response to psychosocial stress • cell surface receptor signaling pathway • behavior • learning or memory • nervous system process • cognition • transport • secretion • regulation of hormone levels • cell-cell signaling • export from cell • hormone secretion • establishment of localization • localization • secretion by cell • signal release • hormone transport • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • protein localization • establishment of protein localization • cellular localization • nitrogen compound transport • protein targeting • protein transmembrane transport • cellular macromolecule localization • establishment of localization in cell • post-translational protein targeting to membrane, translocation • establishment of protein localization to endoplasmic reticulum • protein localization to endoplasmic reticulum • establishment of protein localization to membrane • intracellular protein transmembrane transport • intracellular transport • post-translational protein targeting to endoplasmic reticulum membrane • localization within membrane • protein localization to membrane • protein targeting to membrane • transmembrane transport • establishment of protein localization to organelle • protein transport • macromolecule localization • protein localization to organelle • intracellular protein transport • protein targeting to ER • negative regulation of blood pressure • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of chemical stimulus • sensory perception • sensory perception of smell • cellular response to nitrogen compound • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • regulation of secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • amide transport • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • organelle membrane • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • response to hypoxia • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding
SCOP2	Domain Identifier	• G protein-coupled receptor-like • FnI-like domain • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • FnI-like domain • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HNO
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	HNO
Name	N-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine
Synonyms
Identifier
Formula	C12 H13 Cl2 N3
Molecular Weight	270.158
SMILES
PubChem	156022738
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	0
Total Bonds	31
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43220
Sequence	>7DUQ_nogp_Chain_R T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S S P E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F R H L H C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S T A A Q Q H Q W D G L L S Y Q D S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S V L S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E D E G C W T R N S N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N D I K C R L A K S T L T L I P L L G T H E V I F A F V M D E H A R G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E V Q L E F R K S W E R W R L E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9IVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839	chim(NtGi1-Gs)/β2/γ2	3.22	2024-11-13	10.1016/j.apsb.2024.09.002
	9IVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839		3.22	2024-11-13	10.1016/j.apsb.2024.09.002
	8YW3	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8WG7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.54	2024-03-06	10.1038/s41421-024-00649-0
	8WG7 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.54	2024-03-06	10.1038/s41421-024-00649-0
	8JIS	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-	chim(NtGi1-Gs)/β1/γ2	2.46	2023-11-08	10.1073/pnas.2303696120
	8JIS (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-		2.46	2023-11-08	10.1073/pnas.2303696120
	8JIR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-	chim(NtGi1-Gs)/β1/γ2	2.57	2023-09-06	10.1073/pnas.2303696120
	8JIR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-		2.57	2023-09-06	10.1073/pnas.2303696120
	8JIP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-	chim(NtGi1-Gs)/β1/γ2	2.85	2023-09-06	10.1073/pnas.2303696120
	8JIP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-		2.85	2023-09-06	10.1073/pnas.2303696120
	9IVG	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	chim(NtGi1-Gs)/β1/γ2	3	2024-11-27	10.1016/j.apsb.2024.09.002
	9IVG (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-		3	2024-11-27	10.1016/j.apsb.2024.09.002
	9J1P	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-	chim(NtGi1-Gs)/β1/γ2	2.99	2025-02-26	10.1021/jacs.4c12808
	9J1P (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-		2.99	2025-02-26	10.1021/jacs.4c12808
	7X8S	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-	Gs/β1/γ2	3.09	2022-06-29	10.1073/pnas.2200155119
	7X8S (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-		3.09	2022-06-29	10.1073/pnas.2200155119
	7X8R	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-	Gs/β1/γ2	2.61	2022-06-29	10.1073/pnas.2200155119
	7X8R (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-		2.61	2022-06-29	10.1073/pnas.2200155119
	7S15	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 134611223	-	-	3.8	2022-06-08	10.1021/acs.jmedchem.1c01856
	7RGP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2022-04-13	10.1073/pnas.2116506119
	7RGP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		2.9	2022-04-13	10.1073/pnas.2116506119
	7RG9	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-04-13	10.1073/pnas.2116506119
	7RG9 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.2	2022-04-13	10.1073/pnas.2116506119
	7VBH	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3	2022-04-06	10.1038/s41467-022-28683-0
	7VBH (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-		3	2022-04-06	10.1038/s41467-022-28683-0
	7VBI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-	Gs/β1/γ2	3	2022-03-02	10.1038/s41467-022-28683-0
	7VBI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-		3	2022-03-02	10.1038/s41467-022-28683-0
	7FIM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	10.1038/s41467-022-28683-0
	7FIM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	10.1038/s41467-022-28683-0
	7LLY	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-	Gs/β1/γ2	3.3	2022-01-12	10.1038/s41467-021-27760-0
	7LLY (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-		3.3	2022-01-12	10.1038/s41467-021-27760-0
	7LLL	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	3.7	2022-01-12	10.1038/s41467-021-27760-0
	7LLL (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		3.7	2022-01-12	10.1038/s41467-021-27760-0
	7S3I	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.51	2022-01-05	10.1038/s41589-021-00945-w
	7S3I (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.51	2022-01-05	10.1038/s41589-021-00945-w
	7S1M	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-	Gs/β1/γ2	2.41	2022-01-05	10.1038/s41589-021-00945-w
	7S1M (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-		2.41	2022-01-05	10.1038/s41589-021-00945-w
	7RTB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-	Gs/β1/γ2	2.14	2021-10-06	10.1016/j.bbrc.2021.09.016
	7RTB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-		2.14	2021-10-06	10.1016/j.bbrc.2021.09.016
	7EVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	2.5	2021-08-11	10.1038/s41467-021-24058-z
	7EVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		2.5	2021-08-11	10.1038/s41467-021-24058-z
	7DUR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	3.3	2021-08-11	10.1038/s41467-021-24058-z
	7DUR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		3.3	2021-08-11	10.1038/s41467-021-24058-z
	7KI1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-	Gs/β1/γ2	2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI1 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-		2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI0	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-	Gs/β1/γ2	2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI0 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-		2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7DUQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738	Gs/β1/γ2	2.5	2021-07-14	10.1038/s41467-021-24058-z
	7DUQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738		2.5	2021-07-14	10.1038/s41467-021-24058-z
	7E14	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738	Gs/β1/γ2	2.9	2021-07-07	10.1038/s41467-021-24058-z
	7E14 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738		2.9	2021-07-07	10.1038/s41467-021-24058-z
	7LCK	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	3.24	2021-01-20	10.1016/j.str.2021.04.008
	7LCJ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	2.82	2021-01-20	10.1016/j.str.2021.04.008
	7LCI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.9	2021-01-20	10.1016/j.str.2021.04.008
	7LCI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.9	2021-01-20	10.1016/j.str.2021.04.008
	6XOX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-	chim(NtGi1-Gs)/β1/γ2	3.1	2020-11-18	10.1073/pnas.2014879117
	6XOX (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-		3.1	2020-11-18	10.1073/pnas.2014879117
	6X1A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.5	2020-09-09	10.1016/j.molcel.2020.09.020
	6X1A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.5	2020-09-09	10.1016/j.molcel.2020.09.020
	6X19	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-	Gs/β1/γ2	2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X19 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-		2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X18	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X18 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	7C2E	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-	Gs/β1/γ2	4.2	2020-08-26	10.1038/s41422-020-0384-8
	7C2E (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-		4.2	2020-08-26	10.1038/s41422-020-0384-8
	6VCB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440	Gs/β1/γ2	3.3	2020-07-22	10.1038/s41589-020-0589-7
	6VCB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440		3.3	2020-07-22	10.1038/s41589-020-0589-7
	6LN2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	3.2	2020-03-18	10.1038/s41467-020-14934-5
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	10.1038/s41586-019-1902-z
	6KK7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	3.1	2019-11-13	10.1107/S2052252519013496
	6KK1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	2.8	2019-11-13	10.1107/S2052252519013496
	6KJV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	2.8	2019-11-13	10.1107/S2052252519013496
	6B3J	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-	Gs/β1/γ2	3.3	2018-02-21	10.1038/nature25773
	6B3J (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-		3.3	2018-02-21	10.1038/nature25773
	5NX2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	-	3.7	2017-06-14	10.1038/nature22800
	5VEW	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.7	2017-05-24	10.1038/nature22378
	5VAI	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-	Gs/β1/γ2	4.1	2017-05-24	10.1038/nature22394
	5VAI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-		4.1	2017-05-24	10.1038/nature22394
	5VEX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	NNC0640	-	3	2017-05-17	10.1038/nature22378

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7DUQ_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.