psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W33	19.82	Yes	Yes	1	0	3
2	L:L:?1	R:R:Q140	5.15	Yes	Yes	1	0	4
3	L:L:?1	R:R:L141	17.84	Yes	No	0	0	5
4	L:L:?1	R:R:L144	8.92	Yes	No	0	0	6
5	L:L:?1	R:R:K197	10	Yes	No	0	0	6
6	L:L:?1	R:R:L201	6.24	Yes	No	1	0	7
7	L:L:?1	R:R:K202	3.63	Yes	No	1	0	4
8	L:L:?1	R:R:C226	5.11	Yes	No	0	0	9
9	L:L:?1	R:R:T298	7.6	Yes	No	1	0	5
10	L:L:?1	R:R:R299	3.91	Yes	No	0	0	4
11	L:L:?1	R:R:F381	7.85	Yes	No	1	0	4
12	L:L:?1	R:R:L384	5.35	Yes	No	0	0	5
13	L:L:?1	R:R:L388	4.46	Yes	No	0	0	7
14	R:R:L32	R:R:S31	6.01	No	No	0	4	4
15	R:R:L32	R:R:Y205	14.07	No	Yes	0	4	3
16	R:R:L201	R:R:W33	4.56	No	Yes	1	7	3
17	R:R:W33	R:R:Y205	11.58	Yes	Yes	1	3	3
18	R:R:Q221	R:R:W33	6.57	No	Yes	0	4	3
19	R:R:T298	R:R:W33	7.28	No	Yes	1	5	3
20	R:R:Q221	R:R:V36	5.73	No	No	0	4	2
21	R:R:Q37	R:R:R40	5.84	No	No	0	4	2
22	R:R:Q37	R:R:R299	9.35	No	No	0	4	4
23	R:R:R43	R:R:W39	8	Yes	No	0	4	5
24	R:R:W214	R:R:W39	8.43	No	No	0	1	5
25	R:R:R40	R:R:R43	3.2	No	Yes	0	2	4
26	R:R:C46	R:R:Y42	9.41	No	No	0	8	6
27	R:R:L218	R:R:R43	6.07	No	Yes	0	3	4
28	R:R:R44	R:R:R48	8.53	No	No	0	3	4
29	R:R:Q45	R:R:R48	9.35	No	No	0	5	4
30	R:R:E52	R:R:R48	11.63	No	No	0	2	4
31	R:R:D53	R:R:P54	6.44	No	No	0	3	2
32	R:R:E138	R:R:Q140	7.65	No	Yes	0	2	4
33	R:R:E139	R:R:Q140	8.92	No	Yes	0	2	4
34	R:R:F381	R:R:Q140	4.68	No	Yes	1	4	4
35	R:R:F143	R:R:I147	3.77	No	No	0	4	6
36	R:R:I146	R:R:Y145	3.63	No	Yes	0	4	5
37	R:R:Y145	R:R:Y148	9.93	Yes	Yes	1	5	7
38	R:R:T149	R:R:Y145	12.48	No	Yes	1	7	5
39	R:R:D198	R:R:Y145	13.79	No	Yes	1	7	5
40	R:R:K202	R:R:Y145	8.36	No	Yes	1	4	5
41	R:R:T149	R:R:Y148	4.99	No	Yes	1	7	7
42	R:R:D198	R:R:Y148	3.45	No	Yes	1	7	7
43	R:R:L388	R:R:Y148	5.86	No	Yes	0	7	7
44	R:R:G151	R:R:S392	3.71	No	No	0	8	9
45	R:R:F393	R:R:G151	6.02	No	No	0	7	8
46	R:R:A191	R:R:Y152	5.34	No	Yes	0	7	7
47	R:R:V194	R:R:Y152	8.83	No	Yes	0	7	7
48	R:R:T391	R:R:Y152	3.75	No	Yes	0	6	7
49	R:R:S392	R:R:Y152	16.53	No	Yes	0	9	7
50	R:R:G395	R:R:S155	3.71	No	No	0	9	9
51	R:R:F156	R:R:I188	5.02	No	No	0	7	7
52	R:R:F156	R:R:L192	4.87	No	No	0	7	3
53	R:R:F184	R:R:L159	6.09	No	Yes	0	8	9
54	R:R:F187	R:R:L159	3.65	Yes	Yes	0	8	9
55	R:R:I188	R:R:L159	4.28	No	Yes	0	7	9
56	R:R:A162	R:R:C403	3.61	No	Yes	0	9	9
57	R:R:F184	R:R:S163	3.96	No	No	0	8	6
58	R:R:F169	R:R:I165	3.77	Yes	No	2	7	8
59	R:R:C403	R:R:I165	4.91	Yes	No	0	9	8
60	R:R:F413	R:R:I165	3.77	No	No	2	5	8
61	R:R:L166	R:R:N177	4.12	No	No	0	8	9
62	R:R:F184	R:R:L166	4.87	No	No	0	8	8
63	R:R:C403	R:R:L166	3.17	Yes	No	0	9	8
64	R:R:L167	R:R:L181	5.54	No	No	0	3	6
65	R:R:F169	R:R:L172	4.87	Yes	No	2	7	9
66	R:R:E412	R:R:F169	20.99	Yes	Yes	2	8	7
67	R:R:F169	R:R:F413	4.29	Yes	No	2	7	5
68	R:R:H173	R:R:R170	6.77	No	No	0	7	8
69	R:R:E412	R:R:H171	11.08	Yes	No	0	8	7
70	R:R:E412	R:R:L172	6.63	Yes	No	2	8	9
71	R:R:H173	R:R:Y178	8.71	No	No	0	7	6
72	R:R:C174	R:R:R176	5.57	No	No	0	8	9
73	R:R:C174	R:R:N177	4.72	No	No	0	8	9
74	R:R:T175	R:R:Y250	6.24	No	Yes	0	7	8
75	R:R:E262	R:R:T175	4.23	No	No	0	6	7
76	R:R:R176	R:R:Y250	4.12	No	Yes	0	9	8
77	R:R:F266	R:R:Y178	7.22	No	No	0	6	6
78	R:R:E247	R:R:I179	5.47	Yes	No	0	9	8
79	R:R:I179	R:R:Y250	7.25	No	Yes	0	8	8
80	R:R:E247	R:R:H180	13.54	Yes	No	0	9	9
81	R:R:H180	R:R:Y402	8.71	No	No	0	9	8
82	R:R:N182	R:R:W243	18.08	No	Yes	6	9	9
83	R:R:N182	R:R:W274	5.65	No	No	6	9	9
84	R:R:E247	R:R:L183	6.63	Yes	No	0	9	9
85	R:R:N240	R:R:S186	5.96	No	No	0	9	9
86	R:R:S186	R:R:W243	3.71	No	Yes	0	9	9
87	R:R:F187	R:R:N240	15.71	Yes	No	0	8	9
88	R:R:F187	R:R:G395	4.52	Yes	No	0	8	9
89	R:R:F187	R:R:V398	5.24	Yes	No	0	8	9
90	R:R:C236	R:R:L189	4.76	No	No	0	5	7
91	R:R:R190	R:R:V237	9.15	Yes	No	0	8	6
92	R:R:N240	R:R:R190	13.26	No	Yes	0	9	8
93	R:R:R190	R:R:Y241	11.32	Yes	No	0	8	8
94	R:R:R190	R:R:T391	3.88	Yes	No	0	8	6
95	R:R:I196	R:R:L192	4.28	No	No	0	5	3
96	R:R:M233	R:R:S193	6.13	No	No	0	6	6
97	R:R:C236	R:R:S193	6.89	No	No	0	5	6
98	R:R:K197	R:R:M233	4.32	No	No	0	6	6
99	R:R:D198	R:R:K202	6.91	No	No	1	7	4
100	R:R:L201	R:R:Y205	7.03	No	Yes	1	7	3
101	R:R:T207	R:R:W203	7.28	No	No	0	3	3
102	R:R:S206	R:R:T207	3.2	No	No	0	4	3
103	R:R:H212	R:R:Q210	13.6	No	No	0	3	4
104	R:R:Q210	R:R:Q213	17.92	No	No	0	4	4
105	R:R:Q211	R:R:W214	13.14	No	No	0	4	1
106	R:R:G216	R:R:S219	3.71	No	No	0	2	5
107	R:R:L218	R:R:Q221	3.99	No	No	0	3	4
108	R:R:S223	R:R:S225	3.26	No	No	0	4	3
109	R:R:L224	R:R:R227	4.86	No	Yes	0	3	8
110	R:R:C226	R:R:C296	7.28	No	No	0	9	9
111	R:R:D293	R:R:R227	11.91	No	Yes	4	7	8
112	R:R:C296	R:R:R227	4.18	No	Yes	0	9	8
113	R:R:R227	R:R:W297	28.99	Yes	Yes	4	8	8
114	R:R:F230	R:R:Q234	5.86	No	No	5	5	7
115	R:R:F230	R:R:W284	6.01	No	Yes	5	5	8
116	R:R:L231	R:R:W284	5.69	No	Yes	0	5	8
117	R:R:L231	R:R:W297	3.42	No	Yes	0	5	8
118	R:R:Q234	R:R:W284	3.29	No	Yes	5	7	8
119	R:R:I309	R:R:Q234	8.23	Yes	No	5	7	7
120	R:R:W274	R:R:Y235	4.82	No	No	0	9	9
121	R:R:A238	R:R:P277	3.74	No	Yes	0	6	9
122	R:R:A239	R:R:P277	3.74	No	Yes	0	8	9
123	R:R:I313	R:R:Y241	7.25	No	No	0	7	8
124	R:R:E364	R:R:Y241	8.98	Yes	No	0	8	8
125	R:R:L245	R:R:Y242	3.52	No	Yes	0	8	6
126	R:R:P277	R:R:Y242	4.17	Yes	Yes	0	9	6
127	R:R:A316	R:R:Y242	4	No	Yes	0	7	6
128	R:R:V246	R:R:W243	7.36	No	Yes	0	8	9
129	R:R:G273	R:R:W243	8.44	No	Yes	0	9	9
130	R:R:W243	R:R:W274	24.37	Yes	No	6	9	9
131	R:R:V246	R:R:Y269	3.79	No	Yes	0	8	7
132	R:R:E247	R:R:L359	9.28	Yes	No	0	9	9
133	R:R:G248	R:R:I323	3.53	No	No	0	8	8
134	R:R:V249	R:R:Y269	3.79	No	Yes	0	6	7
135	R:R:L254	R:R:Y250	12.89	No	Yes	0	8	8
136	R:R:Y250	R:R:Y269	6.95	Yes	Yes	0	8	7
137	R:R:L251	R:R:L255	4.15	No	No	0	9	8
138	R:R:L251	R:R:V327	4.47	No	No	0	9	9
139	R:R:A256	R:R:Y252	6.67	No	No	0	6	8
140	R:R:R326	R:R:Y252	8.23	No	No	0	8	8
141	R:R:S258	R:R:T253	6.4	No	No	0	7	7
142	R:R:T253	R:R:Y269	3.75	No	Yes	0	7	7
143	R:R:I330	R:R:L255	4.28	No	No	0	9	8
144	R:R:Q263	R:R:R267	7.01	No	No	0	5	4
145	R:R:I265	R:R:Y269	3.63	No	Yes	0	5	7
146	R:R:F266	R:R:V270	5.24	No	No	0	6	5
147	R:R:G273	R:R:I272	3.53	No	No	0	9	6
148	R:R:P277	R:R:V276	3.53	Yes	No	0	9	3
149	R:R:L278	R:R:V282	4.47	No	No	0	3	3
150	R:R:F280	R:R:P312	15.89	No	No	0	5	8
151	R:R:I309	R:R:V281	4.61	Yes	No	0	7	6
152	R:R:P283	R:R:V282	5.3	No	No	0	5	3
153	R:R:I308	R:R:W284	7.05	No	Yes	0	8	8
154	R:R:I309	R:R:W284	7.05	Yes	Yes	5	7	8
155	R:R:V287	R:R:Y305	8.83	No	Yes	0	4	4
156	R:R:K288	R:R:W297	19.73	No	Yes	0	8	8
157	R:R:L290	R:R:Y289	4.69	No	No	0	3	3
158	R:R:D293	R:R:Y289	4.6	No	No	4	7	3
159	R:R:W297	R:R:Y289	6.75	Yes	No	4	8	3
160	R:R:E292	R:R:Y291	6.73	Yes	No	3	6	3
161	R:R:Y291	R:R:Y305	6.95	No	Yes	3	3	4
162	R:R:E292	R:R:E294	6.34	Yes	No	3	6	4
163	R:R:E292	R:R:S301	5.75	Yes	No	3	6	3
164	R:R:E292	R:R:Y305	6.73	Yes	Yes	3	6	4
165	R:R:D293	R:R:W297	12.28	No	Yes	4	7	8
166	R:R:E294	R:R:S301	4.31	No	No	3	4	3
167	R:R:C296	R:R:T298	5.07	No	No	0	9	5
168	R:R:N300	R:R:W306	20.34	No	No	0	6	6
169	R:R:N302	R:R:Y305	10.47	No	Yes	0	5	4
170	R:R:I309	R:R:W306	3.52	Yes	No	0	7	6
171	R:R:R310	R:R:W306	8	No	No	0	6	6
172	R:R:I313	R:R:R310	6.26	No	No	0	7	6
173	R:R:L311	R:R:P312	3.28	No	No	0	4	8
174	R:R:F315	R:R:V319	6.55	No	No	0	4	6
175	R:R:E364	R:R:I317	4.1	Yes	Yes	0	8	7
176	R:R:F321	R:R:V325	5.24	No	No	0	6	5
177	R:R:F321	R:R:T362	3.89	No	No	0	6	7
178	R:R:F321	R:R:V365	7.87	No	No	0	6	6
179	R:R:F324	R:R:I328	6.28	No	No	0	9	7
180	R:R:F324	R:R:L356	6.09	No	No	0	9	9
181	R:R:F324	R:R:T362	10.38	No	No	0	9	7
182	R:R:I328	R:R:T353	6.08	No	No	0	7	9
183	R:R:L349	R:R:V332	4.47	No	No	0	9	6
184	R:R:L335	R:R:N338	6.87	No	No	0	8	6
185	R:R:L335	R:R:R348	3.64	No	No	0	8	8
186	R:R:K351	R:R:R348	8.66	No	No	0	8	8
187	R:R:R348	R:R:S352	6.59	No	No	0	8	9
188	R:R:K351	R:R:T355	6.01	No	No	0	8	8
189	R:R:L356	R:R:L360	6.92	No	No	0	9	9
190	R:R:I357	R:R:P358	3.39	No	No	0	8	9
191	R:R:L359	R:R:Y402	16.41	No	No	0	9	8
192	R:R:G361	R:R:H363	3.18	No	Yes	0	9	8
193	R:R:E364	R:R:H363	13.54	Yes	Yes	0	8	8
194	R:R:H363	R:R:Q394	19.78	Yes	No	0	8	9
195	R:R:E364	R:R:E387	3.81	Yes	No	0	8	8
196	R:R:F367	R:R:V370	10.49	No	No	0	7	5
197	R:R:F367	R:R:K383	12.41	No	No	0	7	7
198	R:R:E387	R:R:F367	9.33	No	No	0	8	7
199	R:R:G377	R:R:R380	9.01	No	No	0	4	5
200	R:R:L379	R:R:T378	5.9	No	No	0	3	2
201	R:R:K383	R:R:L379	5.64	No	No	0	7	3
202	R:R:F381	R:R:I382	5.02	No	No	0	4	4
203	R:R:K383	R:R:L384	8.46	No	No	0	7	5
204	R:R:I400	R:R:L396	5.71	No	No	0	6	7
205	R:R:L401	R:R:Y402	3.52	No	No	0	8	8
206	R:R:C403	R:R:F404	5.59	Yes	No	0	9	8
207	R:R:E408	R:R:N406	5.26	No	No	0	9	9
208	R:R:Q410	R:R:R414	4.67	No	No	0	7	6
209	R:R:E412	R:R:K415	4.05	Yes	No	0	8	7
210	R:R:E418	R:R:W417	9.81	No	No	7	4	5
211	R:R:R421	R:R:W417	13	No	No	7	4	5
212	R:R:E418	R:R:R421	4.65	No	No	7	4	4
213	R:R:P358	R:R:Q394	3.16	No	No	0	9	9
214	R:R:A399	R:R:L159	3.15	No	Yes	0	8	9
215	R:R:A208	R:R:L217	3.15	No	No	0	4	4
216	L:L:?1	R:R:R380	3.13	Yes	No	0	0	5
217	R:R:I272	R:R:S271	3.1	No	No	0	6	3
218	R:R:F280	R:R:Y242	3.09	No	Yes	0	5	6
219	R:R:I323	R:R:V249	3.07	No	No	0	8	6
220	R:R:I366	R:R:V365	3.07	No	No	0	6	6
221	R:R:I357	R:R:T353	3.04	No	No	0	8	9
222	R:R:I382	R:R:T386	3.04	No	No	0	4	4
223	R:R:A208	R:R:Q213	3.03	No	No	0	4	4
224	R:R:F260	R:R:W264	3.01	No	No	0	7	5
225	R:R:L268	R:R:S271	3	No	No	0	2	3
226	R:R:L245	R:R:V249	2.98	No	No	0	8	6
227	R:R:L245	R:R:V319	2.98	No	No	0	8	6
228	R:R:L356	R:R:V327	2.98	No	No	0	9	9
229	R:R:L401	R:R:T355	2.95	No	No	0	8	8
230	R:R:I345	R:R:K336	2.91	No	No	0	5	6
231	L:L:?1	R:R:V229	2.88	Yes	No	0	0	7
232	R:R:I317	R:R:N320	2.83	Yes	No	0	7	9
233	R:R:W417	R:R:W420	2.81	No	No	0	5	4
234	R:R:L183	R:R:L244	2.77	No	No	0	9	9
235	R:R:M397	R:R:Q394	2.72	No	No	0	5	9
236	R:R:D222	R:R:L218	2.71	No	No	0	6	3
237	R:R:E294	R:R:K288	2.7	No	No	0	4	8
238	R:R:E423	R:R:L422	2.65	No	No	0	4	4
239	R:R:F390	R:R:S389	2.64	No	No	0	6	5
240	R:R:F413	R:R:V409	2.62	No	No	0	5	9
241	R:R:S219	R:R:Y220	2.54	No	No	0	5	3
242	R:R:S223	R:R:Y220	2.54	No	No	0	4	3
243	R:R:F385	R:R:I147	2.51	No	No	0	6	6
244	R:R:F404	R:R:I161	2.51	No	No	0	8	4
245	R:R:F260	R:R:I265	2.51	No	No	0	7	5
246	R:R:S261	R:R:W264	2.47	No	No	0	7	5
247	R:R:I323	R:R:Y252	2.42	No	No	0	8	8
248	R:R:Q47	R:R:R44	2.34	No	No	0	3	3
249	R:R:L217	R:R:Y205	2.34	No	Yes	0	4	3
250	R:R:L278	R:R:Y235	2.34	No	No	0	3	9
251	R:R:E41	R:R:R44	2.33	No	No	0	4	3
252	R:R:N304	R:R:Y305	2.33	No	Yes	0	3	4
253	R:R:F390	R:R:H363	2.26	No	Yes	0	6	8
254	R:R:F195	R:R:Y152	2.06	No	Yes	0	7	7
255	R:R:G275	R:R:P277	2.03	No	Yes	0	6	9
256	R:R:W39	R:R:Y42	1.93	No	No	0	5	6
257	R:R:A158	R:R:A399	1.79	No	No	0	7	8
258	R:R:G318	R:R:I317	1.76	No	Yes	0	4	7
259	R:R:G285	R:R:L231	1.71	No	No	0	5	5
260	R:R:C329	R:R:V325	1.71	No	No	0	7	5
261	R:R:D215	R:R:G216	1.68	No	No	0	3	2
262	R:R:D222	R:R:G295	1.68	No	No	0	6	4
263	R:R:A368	R:R:I317	1.62	No	Yes	0	6	7
264	R:R:S352	R:R:V331	1.62	No	No	0	9	8
265	R:R:T149	R:R:V150	1.59	No	No	0	7	5
266	R:R:A158	R:R:L396	1.58	No	No	0	7	7
267	R:R:A368	R:R:L314	1.58	No	No	0	6	4
268	R:R:I161	R:R:S157	1.55	No	No	0	4	3
269	R:R:I328	R:R:V332	1.54	No	No	0	7	6
270	R:R:I400	R:R:V405	1.54	No	No	0	6	6
271	R:R:K336	R:R:V332	1.52	No	No	0	6	6
272	R:R:F369	R:R:G318	1.51	No	No	0	4	4
273	R:R:N182	R:R:V270	1.48	No	No	0	9	5
274	R:R:N406	R:R:V409	1.48	No	No	0	9	9
275	R:R:I330	R:R:K334	1.45	No	No	0	9	9
276	R:R:I345	R:R:K346	1.45	No	No	0	5	6
277	R:R:E412	R:R:S416	1.44	Yes	No	0	8	5
278	R:R:I146	R:R:L142	1.43	No	No	0	4	3
279	R:R:E34	R:R:T35	1.41	No	No	0	4	5
280	R:R:E52	R:R:T51	1.41	No	No	0	2	4
281	R:R:D344	R:R:I345	1.4	No	No	0	7	5
282	R:R:A153	R:R:F195	1.39	No	No	0	6	7
283	R:R:L278	R:R:L279	1.38	No	No	0	3	4
284	R:R:K38	R:R:Q37	1.36	No	No	0	4	4
285	R:R:E408	R:R:N407	1.31	No	No	0	9	6
286	R:R:D53	R:R:E52	1.3	No	No	0	3	2
287	R:R:H173	R:R:L167	1.29	No	No	0	7	3
288	R:R:K415	R:R:R419	1.24	No	No	0	7	7
289	R:R:F393	R:R:L154	1.22	No	No	0	7	5
290	R:R:M204	R:R:Y220	1.2	No	No	0	3	3
291	R:R:Q47	R:R:R43	1.17	No	Yes	0	3	4
292	R:R:F266	R:R:R267	1.07	No	No	0	6	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.45933	15	1	0
2	R:R:W33	9.962	5	1	3
3	R:R:R43	4.61	4	0	4
4	R:R:Q140	6.6	4	1	4
5	R:R:Y145	9.638	5	1	5
6	R:R:Y148	6.0575	4	1	7
7	R:R:Y152	7.302	5	0	7
8	R:R:L159	4.2925	4	0	9
9	R:R:F169	8.48	4	2	7
10	R:R:F187	7.28	4	0	8
11	R:R:R190	9.4025	4	0	8
12	R:R:Y205	8.755	4	1	3
13	R:R:R227	12.485	4	4	8
14	R:R:Y242	3.695	4	0	6
15	R:R:W243	12.392	5	6	9
16	R:R:E247	8.73	4	0	9
17	R:R:Y250	7.49	5	0	8
18	R:R:Y269	4.382	5	0	7
19	R:R:P277	3.442	5	0	9
20	R:R:W284	5.818	5	5	8
21	R:R:E292	6.3875	4	3	6
22	R:R:W297	14.234	5	4	8
23	R:R:Y305	7.062	5	3	4
24	R:R:I309	5.8525	4	5	7
25	R:R:I317	2.5775	4	0	7
26	R:R:H363	9.69	4	0	8
27	R:R:E364	7.6075	4	0	8
28	R:R:C403	4.32	4	0	9
29	R:R:E412	8.838	5	2	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W33	28.7267	19.82	Yes	Yes	1	0	3
2	R:R:W33	R:R:Y205	10.0849	11.58	Yes	Yes	1	3	3
3	R:R:Q221	R:R:W33	23.5411	6.57	No	Yes	0	4	3
4	L:L:?1	R:R:R299	20.0388	3.91	Yes	No	0	0	4
5	R:R:Q37	R:R:R299	18.8892	9.35	No	No	0	4	4
6	R:R:Q37	R:R:R40	16.4831	5.84	No	No	0	4	2
7	R:R:L218	R:R:Q221	21.4892	3.99	No	No	0	3	4
8	R:R:L218	R:R:R43	18.1664	6.07	No	Yes	0	3	4
9	R:R:R40	R:R:R43	15.2559	3.2	No	Yes	0	2	4
10	R:R:R43	R:R:W39	11.3219	8	Yes	No	0	4	5
11	R:R:Q47	R:R:R43	20.2086	1.17	No	Yes	0	3	4
12	R:R:Q47	R:R:R44	18.0015	2.34	No	No	0	3	3
13	R:R:R44	R:R:R48	13.5581	8.53	No	No	0	3	4
14	L:L:?1	R:R:K202	10.2159	3.63	Yes	No	1	0	4
15	L:L:?1	R:R:L384	77.3175	5.35	Yes	No	0	0	5
16	R:R:K383	R:R:L384	77.5746	8.46	No	No	0	7	5
17	R:R:F367	R:R:K383	78.1567	12.41	No	No	0	7	7
18	R:R:E387	R:R:F367	78.6757	9.33	No	No	0	8	7
19	R:R:E364	R:R:E387	78.9183	3.81	Yes	No	0	8	8
20	R:R:E364	R:R:Y241	88.4308	8.98	Yes	No	0	8	8
21	R:R:R190	R:R:Y241	100	11.32	Yes	No	0	8	8
22	R:R:R190	R:R:T391	13.5775	3.88	Yes	No	0	8	6
23	R:R:T391	R:R:Y152	12.2629	3.75	No	Yes	0	6	7
24	R:R:N240	R:R:R190	97.3223	13.26	No	Yes	0	9	8
25	R:R:F187	R:R:N240	37.3854	15.71	Yes	No	0	8	9
26	R:R:F187	R:R:L159	33.1555	3.65	Yes	Yes	0	8	9
27	R:R:F184	R:R:L159	24.618	6.09	No	Yes	0	8	9
28	R:R:F184	R:R:L166	23.284	4.87	No	No	0	8	8
29	R:R:C403	R:R:L166	23.5702	3.17	Yes	No	0	9	8
30	R:R:C403	R:R:I165	17.2884	4.91	Yes	No	0	9	8
31	R:R:N240	R:R:S186	71.8991	5.96	No	No	0	9	9
32	R:R:S186	R:R:W243	71.2539	3.71	No	Yes	0	9	9
33	R:R:N182	R:R:W243	13.2864	18.08	No	Yes	6	9	9
34	R:R:N182	R:R:V270	12.2629	1.48	No	No	0	9	5
35	R:R:F266	R:R:V270	10.9386	5.24	No	No	0	6	5
36	R:R:V246	R:R:W243	55.6682	7.36	No	Yes	0	8	9
37	R:R:V246	R:R:Y269	55.0036	3.79	No	Yes	0	8	7
38	R:R:Y250	R:R:Y269	34.8727	6.95	Yes	Yes	0	8	7
39	R:R:I179	R:R:Y250	30.6039	7.25	No	Yes	0	8	8
40	R:R:E247	R:R:I179	29.4349	5.47	Yes	No	0	9	8
41	R:R:E247	R:R:H180	12.9226	13.54	Yes	No	0	9	9
42	R:R:H180	R:R:Y402	11.6566	8.71	No	No	0	9	8
43	R:R:E247	R:R:L359	12.9226	9.28	Yes	No	0	9	9
44	R:R:L359	R:R:Y402	11.6566	16.41	No	No	0	9	8
45	R:R:L217	R:R:Y205	11.4431	2.34	No	Yes	0	4	3
46	R:R:C296	R:R:R227	15.6439	4.18	No	Yes	0	9	8
47	R:R:C296	R:R:T298	10.9386	5.07	No	No	0	9	5
48	R:R:R227	R:R:W297	13.3107	28.99	Yes	Yes	4	8	8
49	R:R:L231	R:R:W297	17.8414	3.42	No	Yes	0	5	8
50	R:R:L231	R:R:W284	18.3362	5.69	No	Yes	0	5	8
51	R:R:I309	R:R:W284	18.4768	7.05	Yes	Yes	5	7	8
52	R:R:V249	R:R:Y269	24.9673	3.79	No	Yes	0	6	7
53	R:R:L245	R:R:V249	17.463	2.98	No	No	0	8	6
54	R:R:L245	R:R:Y242	13.5775	3.52	No	Yes	0	8	6
55	R:R:I313	R:R:Y241	23.3083	7.25	No	No	0	7	8
56	R:R:E364	R:R:H363	38.4138	13.54	Yes	Yes	0	8	8
57	R:R:H363	R:R:Q394	33.7958	19.78	Yes	No	0	8	9
58	R:R:P358	R:R:Q394	31.4286	3.16	No	No	0	9	9
59	R:R:I357	R:R:P358	30.2304	3.39	No	No	0	8	9
60	R:R:I357	R:R:T353	29.0226	3.04	No	No	0	8	9
61	R:R:I328	R:R:T353	27.805	6.08	No	No	0	7	9
62	R:R:F324	R:R:I328	19.0104	6.28	No	No	0	9	7
63	R:R:K288	R:R:W297	12.9614	19.73	No	Yes	0	8	8
64	R:R:E294	R:R:K288	11.5595	2.7	No	No	0	4	8
65	R:R:I309	R:R:W306	20.7034	3.52	Yes	No	0	7	6
66	R:R:I313	R:R:R310	22.1829	6.26	No	No	0	7	6
67	R:R:L401	R:R:Y402	20.7179	3.52	No	No	0	8	8
68	R:R:L401	R:R:T355	18.1082	2.95	No	No	0	8	8
69	R:R:K351	R:R:T355	15.6148	6.01	No	No	0	8	8
70	R:R:K351	R:R:R348	12.9954	8.66	No	No	0	8	8
71	R:R:R310	R:R:W306	21.2079	8	No	No	0	6	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:W33	19.82	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:Q140	5.15	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L141	17.84	1	Yes	No	0	5	0	1
L:L:?1	R:R:L144	8.92	1	Yes	No	0	6	0	1
L:L:?1	R:R:K197	10	1	Yes	No	0	6	0	1
L:L:?1	R:R:L201	6.24	1	Yes	No	0	7	0	1
L:L:?1	R:R:K202	3.63	1	Yes	No	0	4	0	1
L:L:?1	R:R:C226	5.11	1	Yes	No	0	9	0	1
L:L:?1	R:R:T298	7.6	1	Yes	No	0	5	0	1
L:L:?1	R:R:R299	3.91	1	Yes	No	0	4	0	1
L:L:?1	R:R:F381	7.85	1	Yes	No	0	4	0	1
L:L:?1	R:R:L384	5.35	1	Yes	No	0	5	0	1
L:L:?1	R:R:L388	4.46	1	Yes	No	0	7	0	1
R:R:L201	R:R:W33	4.56	1	No	Yes	7	3	1	1
R:R:W33	R:R:Y205	11.58	1	Yes	Yes	3	3	1	2
R:R:Q221	R:R:W33	6.57	0	No	Yes	4	3	2	1
R:R:T298	R:R:W33	7.28	1	No	Yes	5	3	1	1
R:R:Q37	R:R:R299	9.35	0	No	No	4	4	2	1
R:R:E138	R:R:Q140	7.65	0	No	Yes	2	4	2	1
R:R:E139	R:R:Q140	8.92	0	No	Yes	2	4	2	1
R:R:F381	R:R:Q140	4.68	1	No	Yes	4	4	1	1
R:R:Y145	R:R:Y148	9.93	1	Yes	Yes	5	7	2	2
R:R:D198	R:R:Y145	13.79	1	No	Yes	7	5	2	2
R:R:K202	R:R:Y145	8.36	1	No	Yes	4	5	1	2
R:R:D198	R:R:Y148	3.45	1	No	Yes	7	7	2	2
R:R:L388	R:R:Y148	5.86	0	No	Yes	7	7	1	2
R:R:K197	R:R:M233	4.32	0	No	No	6	6	1	2
R:R:D198	R:R:K202	6.91	1	No	No	7	4	2	1
R:R:L201	R:R:Y205	7.03	1	No	Yes	7	3	1	2
R:R:C226	R:R:C296	7.28	0	No	No	9	9	1	2
R:R:C296	R:R:T298	5.07	0	No	No	9	5	2	1
R:R:G377	R:R:R380	9.01	0	No	No	4	5	2	1
R:R:F381	R:R:I382	5.02	1	No	No	4	4	1	2
R:R:K383	R:R:L384	8.46	0	No	No	7	5	2	1
L:L:?1	R:R:R380	3.13	1	Yes	No	0	5	0	1
L:L:?1	R:R:V229	2.88	1	Yes	No	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7X8S_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.17
Number of Linked Nodes	277
Number of Links	292
Number of Hubs	29
Number of Links mediated by Hubs	125
Number of Communities	7
Number of Nodes involved in Communities	36
Number of Links involved in Communities	46

Path Summary
Number Of Nodes in MetaPath	72
Number Of Links MetaPath	71
Number of Shortest Paths	40797
Length Of Smallest Path	3
Average Path Length	14.8687
Length of Longest Path	34
Minimum Path Strength	1.355
Average Path Strength	7.17119
Maximum Path Strength	24.36
Minimum Path Correlation	0.7
Average Path Correlation	0.949012
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	55.815
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	31.6408
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • heart process • multicellular organismal process • system process • regulation of biological process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • regulation of blood pressure • positive regulation of blood pressure • cellular response to stimulus • regulation of cellular process • response to stimulus • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to stress • response to psychosocial stress • cell surface receptor signaling pathway • behavior • learning or memory • nervous system process • cognition • transport • secretion • regulation of hormone levels • cell-cell signaling • export from cell • hormone secretion • establishment of localization • localization • secretion by cell • signal release • hormone transport • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • establishment of protein localization • cellular localization • protein targeting • protein transmembrane transport • establishment of localization in cell • post-translational protein targeting to membrane, translocation • intracellular protein localization • establishment of protein localization to endoplasmic reticulum • establishment of protein localization to membrane • intracellular protein transmembrane transport • intracellular transport • post-translational protein targeting to endoplasmic reticulum membrane • localization within membrane • protein targeting to membrane • transmembrane transport • establishment of protein localization to organelle • protein transport • macromolecule localization • intracellular protein transport • protein targeting to ER • negative regulation of blood pressure • cellular anatomical structure • membrane • cell periphery • plasma membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to oxygen levels • response to abiotic stimulus • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • cell body • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • signaling receptor binding • G protein-coupled receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • mu-type opioid receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • adrenergic receptor binding • D1 dopamine receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • ionotropic glutamate receptor binding • glutamate receptor binding • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • molecular function regulator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • insulin-like growth factor receptor binding • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	WB2
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	WB2
Name	2,4-bis(3-methoxy-4-thiophen-2-ylcarbonyloxy-phenyl)-1,3-bis[[4-(2-methylpropanoylamino)phenyl]carbonylamino]cyclobutane-1,3-dicarboxylic acid
Synonyms
Identifier
Formula	C52 H48 N4 O14 S2
Molecular Weight	1,017.086
SMILES
PubChem
Formal Charge	0
Total Atoms	120
Total Chiral Atoms	2
Total Bonds	126
Total Aromatic Bonds	34


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43220
Sequence	>7X8S_nogp_Chain_R S L W E T V Q K W R E Y R R Q C Q R S L T E D P E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F R H L H C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S T A A Q Q H Q W D G L L S Y Q D S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S V F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E D E G C W T R N S N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N D I K C R L A K S T L T L I P L L G T H E V I F A F V G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E V Q L E F R K S W E R W R L E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5VEX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	NNC0640	-	3	2017-05-17	doi.org/10.1038/nature22378
	5VAI	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-	Gs/β1/γ2	4.1	2017-05-24	doi.org/10.1038/nature22394
	5VAI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-		4.1	2017-05-24	doi.org/10.1038/nature22394
	5VEW	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.7	2017-05-24	doi.org/10.1038/nature22378
	5NX2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	-	3.7	2017-06-14	doi.org/10.1038/nature22800
	6B3J	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-	Gs/β1/γ2	3.3	2018-02-21	doi.org/10.1038/nature25773
	6B3J (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-		3.3	2018-02-21	doi.org/10.1038/nature25773
	6KJV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.1	2019-11-13	doi.org/10.1107/S2052252519013496
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	6LN2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.2	2020-03-18	doi.org/10.1038/s41467-020-14934-5
	6VCB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440	Gs/β1/γ2	3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	6VCB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440		3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	7C2E	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-	Gs/β1/γ2	4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	7C2E (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-		4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	6X18	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X18 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6XOX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-	chim(NtGi1-Gs)/β1/γ2	3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	6XOX (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-		3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	7LCI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCJ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	2.82	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCK	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	3.24	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7E14	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738	Gs/β1/γ2	2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7E14 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738		2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7DUQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738	Gs/β1/γ2	2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DUQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738		2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7KI0	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI0 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7DUR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7DUR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7RTB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-	Gs/β1/γ2	2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7RTB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-		2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7S1M	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4-D-Ala	-	Gs/β1/γ2	2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S1M (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4-D-Ala	-		2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7LLL	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLL (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-	Gs/β1/γ2	3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-		3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7FIM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide (non-acylated)	-	Gs/β1/γ2	3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide (non-acylated)	-		3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBH	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7VBH (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-		3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7RG9	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RG9 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7S15	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 134611223	-	-	3.8	2022-06-08	doi.org/10.1021/acs.jmedchem.1c01856
	7X8R	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-	Gs/β1/γ2	2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8R (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-		2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-	Gs/β1/γ2	3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-		3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	8JIP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-	chim(NtGi1-Gs)/β1/γ2	2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-		2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-	chim(NtGi1-Gs)/β1/γ2	2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-		2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIS	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-	chim(NtGi1-Gs)/β1/γ2	2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8JIS (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-		2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8YW3	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	9J1P	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-	chim(NtGi1-Gs)/β1/γ2	2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	9J1P (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-		2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	8WG7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WG7 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	9IVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839	chim(NtGi1-Gs)/β2/γ2	3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	9IVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839		3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	9IVG	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	chim(NtGi1-Gs)/β1/γ2	3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	9IVG (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-		3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	9EBN	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBN (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-	Gs/β1/γ2	3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-		3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	8YWF	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ2	2.74	2025-04-16	To be published
	8YWF (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.74	2025-04-16	To be published
	9BYO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-	Gs/β1/γ2	2.31	2025-06-11	To be published
	9BYO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-		2.31	2025-06-11	To be published
	9C0K	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	2.72	2025-06-11	To be published
	9C0K (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		2.72	2025-06-11	To be published
	9E2A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	3.3	2025-10-29	To be published
	9E2A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		3.3	2025-10-29	To be published

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.