psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E139	R:R:S136	5.75	No	No	0	2	1
2	R:R:E138	R:R:E139	7.61	No	No	0	2	2
3	R:R:F381	R:R:Q140	28.11	No	No	0	4	4
4	R:R:Y145	R:R:Y148	9.93	No	Yes	2	5	7
5	R:R:D198	R:R:Y145	11.49	No	No	2	7	5
6	R:R:I146	R:R:I147	4.42	No	No	0	4	6
7	R:R:Y148	R:R:Y152	3.97	Yes	Yes	2	7	7
8	R:R:V194	R:R:Y148	5.05	No	Yes	2	7	7
9	R:R:D198	R:R:Y148	6.9	No	Yes	2	7	7
10	R:R:L388	R:R:Y148	14.07	No	Yes	0	7	7
11	R:R:F195	R:R:T149	7.78	No	No	0	7	7
12	R:R:F393	R:R:G151	9.03	No	No	0	7	8
13	R:R:R190	R:R:Y152	5.14	Yes	Yes	0	8	7
14	R:R:A191	R:R:Y152	4	No	Yes	0	7	7
15	R:R:V194	R:R:Y152	10.09	No	Yes	2	7	7
16	R:R:S392	R:R:Y152	5.09	No	Yes	0	9	7
17	R:R:F156	R:R:I188	7.54	No	No	0	7	7
18	R:R:F156	R:R:L192	8.53	No	No	0	7	3
19	R:R:F184	R:R:L159	10.96	Yes	No	0	8	9
20	R:R:I188	R:R:L159	9.99	No	No	0	7	9
21	R:R:A162	R:R:F184	4.16	No	Yes	0	9	8
22	R:R:F413	R:R:I165	6.28	No	No	0	5	8
23	R:R:L166	R:R:N177	5.49	Yes	No	0	8	9
24	R:R:L166	R:R:L181	6.92	Yes	No	0	8	6
25	R:R:F184	R:R:L166	4.87	Yes	Yes	5	8	8
26	R:R:C403	R:R:L166	6.35	Yes	Yes	5	9	8
27	R:R:L167	R:R:L181	5.54	No	No	0	3	6
28	R:R:F169	R:R:L172	7.31	Yes	No	1	7	9
29	R:R:E412	R:R:F169	23.32	Yes	Yes	1	8	7
30	R:R:F169	R:R:F413	9.65	Yes	No	0	7	5
31	R:R:F169	R:R:S416	7.93	Yes	No	1	7	5
32	R:R:E412	R:R:H171	11.08	Yes	No	1	8	7
33	R:R:H171	R:R:K415	7.86	No	No	1	7	7
34	R:R:L172	R:R:V409	4.47	No	No	0	9	9
35	R:R:E412	R:R:L172	10.6	Yes	No	1	8	9
36	R:R:H173	R:R:Y178	10.89	No	No	0	7	6
37	R:R:T175	R:R:Y250	7.49	No	Yes	0	7	8
38	R:R:E262	R:R:T175	9.88	No	No	0	6	7
39	R:R:F266	R:R:T175	3.89	Yes	No	0	6	7
40	R:R:N177	R:R:R176	8.44	No	No	0	9	9
41	R:R:R176	R:R:Y250	4.12	No	Yes	0	9	8
42	R:R:E408	R:R:R176	4.65	No	No	0	9	9
43	R:R:F266	R:R:Y178	8.25	Yes	No	0	6	6
44	R:R:I179	R:R:W243	4.7	No	Yes	0	8	9
45	R:R:E247	R:R:I179	5.47	Yes	No	0	9	8
46	R:R:F266	R:R:I179	5.02	Yes	No	0	6	8
47	R:R:E247	R:R:H180	12.31	Yes	No	0	9	9
48	R:R:H180	R:R:Y402	4.36	No	No	0	9	8
49	R:R:N182	R:R:W243	18.08	No	Yes	3	9	9
50	R:R:N182	R:R:V270	4.43	No	No	3	9	5
51	R:R:N182	R:R:W274	10.17	No	Yes	3	9	9
52	R:R:F187	R:R:L183	6.09	Yes	No	4	8	9
53	R:R:L183	R:R:L244	5.54	No	Yes	4	9	9
54	R:R:E247	R:R:L183	5.3	Yes	No	0	9	9
55	R:R:F184	R:R:V398	3.93	Yes	No	0	8	9
56	R:R:C403	R:R:F184	4.19	Yes	Yes	5	9	8
57	R:R:S186	R:R:W243	6.18	No	Yes	3	9	9
58	R:R:S186	R:R:W274	6.18	No	Yes	3	9	9
59	R:R:F187	R:R:N240	16.92	Yes	No	4	8	9
60	R:R:F187	R:R:L244	4.87	Yes	Yes	4	8	9
61	R:R:F187	R:R:Q394	9.37	Yes	No	0	8	9
62	R:R:C236	R:R:L189	6.35	No	No	0	5	7
63	R:R:R190	R:R:V237	3.92	Yes	No	0	8	6
64	R:R:N240	R:R:R190	12.05	No	Yes	0	9	8
65	R:R:R190	R:R:Y241	7.2	Yes	No	0	8	8
66	R:R:M233	R:R:S193	6.13	No	No	0	6	6
67	R:R:C236	R:R:S193	6.89	No	No	0	5	6
68	R:R:D198	R:R:V194	4.38	No	No	2	7	7
69	R:R:F230	R:R:K197	7.44	Yes	No	0	5	6
70	R:R:K197	R:R:M233	7.2	No	No	0	6	6
71	R:R:K202	R:R:Y205	10.75	No	No	0	4	3
72	R:R:M204	R:R:W203	4.65	No	No	0	3	3
73	R:R:T207	R:R:W203	7.28	Yes	No	0	3	3
74	R:R:M204	R:R:Y220	4.79	No	No	0	3	3
75	R:R:A208	R:R:L217	6.3	No	No	0	4	4
76	R:R:D215	R:R:Q213	11.75	No	No	0	3	4
77	R:R:D215	R:R:W214	4.47	No	No	0	3	1
78	R:R:D215	R:R:G216	5.03	No	No	0	3	2
79	R:R:L218	R:R:Q221	7.99	No	No	0	3	4
80	R:R:D222	R:R:E294	9.09	No	No	0	6	4
81	R:R:S223	R:R:S225	6.52	No	No	0	4	3
82	R:R:L224	R:R:R227	6.07	No	Yes	7	3	8
83	R:R:L224	R:R:Y289	7.03	No	No	7	3	3
84	R:R:C226	R:R:C296	7.28	No	No	0	9	9
85	R:R:R227	R:R:Y289	5.14	Yes	No	7	8	3
86	R:R:E294	R:R:R227	15.12	No	Yes	0	4	8
87	R:R:R227	R:R:W297	21.99	Yes	No	0	8	8
88	R:R:F230	R:R:Q234	9.37	Yes	Yes	6	5	7
89	R:R:F230	R:R:W284	5.01	Yes	Yes	6	5	8
90	R:R:F230	R:R:T298	10.38	Yes	No	0	5	5
91	R:R:M233	R:R:Q234	4.08	No	Yes	0	6	7
92	R:R:Q234	R:R:W284	5.48	Yes	Yes	6	7	8
93	R:R:I309	R:R:Q234	8.23	No	Yes	0	7	7
94	R:R:W274	R:R:Y235	6.75	Yes	No	0	9	9
95	R:R:L278	R:R:Y235	8.21	No	No	0	3	9
96	R:R:V281	R:R:Y235	6.31	No	No	0	6	9
97	R:R:L244	R:R:N240	5.49	Yes	No	4	9	9
98	R:R:I313	R:R:Y241	9.67	No	No	0	7	8
99	R:R:E364	R:R:Y241	11.22	No	No	0	8	8
100	R:R:L245	R:R:Y242	4.69	No	Yes	0	8	6
101	R:R:V276	R:R:Y242	7.57	No	Yes	0	3	6
102	R:R:P277	R:R:Y242	6.95	No	Yes	0	9	6
103	R:R:F280	R:R:Y242	10.32	No	Yes	8	5	6
104	R:R:P312	R:R:Y242	4.17	No	Yes	8	8	6
105	R:R:A316	R:R:Y242	5.34	No	Yes	0	7	6
106	R:R:V246	R:R:W243	8.58	No	Yes	0	8	9
107	R:R:V270	R:R:W243	4.9	No	Yes	3	5	9
108	R:R:G273	R:R:W243	8.44	No	Yes	0	9	9
109	R:R:W243	R:R:W274	24.37	Yes	Yes	3	9	9
110	R:R:G361	R:R:L244	5.13	No	Yes	0	9	9
111	R:R:L245	R:R:N320	5.49	No	No	0	8	9
112	R:R:E247	R:R:L359	11.93	Yes	No	0	9	9
113	R:R:G248	R:R:L360	5.13	No	Yes	0	8	9
114	R:R:L254	R:R:Y250	9.38	No	Yes	0	8	8
115	R:R:Y250	R:R:Y269	6.95	Yes	No	0	8	7
116	R:R:L251	R:R:V327	7.45	No	No	0	9	9
117	R:R:A256	R:R:Y252	5.34	No	No	0	6	8
118	R:R:I323	R:R:Y252	4.84	No	No	0	8	8
119	R:R:R326	R:R:Y252	7.2	No	No	0	8	8
120	R:R:F257	R:R:T253	6.49	No	No	0	5	7
121	R:R:L260	R:R:T253	5.9	No	No	0	7	7
122	R:R:L255	R:R:V327	4.47	No	No	0	8	9
123	R:R:I330	R:R:L255	5.71	No	No	0	9	8
124	R:R:A256	R:R:F257	8.32	No	No	0	6	5
125	R:R:I265	R:R:L260	5.71	No	No	0	5	7
126	R:R:S261	R:R:W264	4.94	No	No	0	7	5
127	R:R:Q263	R:R:R267	9.35	No	No	0	5	4
128	R:R:R267	R:R:W264	5	No	No	0	4	5
129	R:R:I265	R:R:Y269	10.88	No	No	0	5	7
130	R:R:F266	R:R:V270	5.24	Yes	No	0	6	5
131	R:R:I272	R:R:L268	4.28	No	No	0	6	2
132	R:R:I272	R:R:V276	4.61	No	No	0	6	3
133	R:R:G275	R:R:L278	5.13	No	No	0	6	3
134	R:R:F280	R:R:I309	6.28	No	No	0	5	7
135	R:R:F280	R:R:P312	18.78	No	No	8	5	8
136	R:R:K288	R:R:W284	13.92	No	Yes	0	8	8
137	R:R:V287	R:R:Y305	6.31	No	Yes	0	4	4
138	R:R:E292	R:R:K288	8.1	Yes	No	0	6	8
139	R:R:K288	R:R:W297	22.05	No	No	0	8	8
140	R:R:L290	R:R:Y291	5.86	No	No	0	3	3
141	R:R:Y291	R:R:Y305	9.93	No	Yes	0	3	4
142	R:R:D293	R:R:E292	5.2	No	Yes	0	7	6
143	R:R:E292	R:R:S301	4.31	Yes	No	0	6	3
144	R:R:N300	R:R:W306	18.08	No	No	0	6	6
145	R:R:N302	R:R:N304	10.9	No	No	9	5	3
146	R:R:N302	R:R:Y305	10.47	No	Yes	9	5	4
147	R:R:N304	R:R:Y305	9.3	No	Yes	9	3	4
148	R:R:R310	R:R:W306	13	Yes	No	0	6	6
149	R:R:L307	R:R:L311	6.92	No	No	0	7	4
150	R:R:L314	R:R:R310	8.5	No	Yes	0	4	6
151	R:R:F369	R:R:L314	4.87	Yes	No	0	4	4
152	R:R:F315	R:R:V319	6.55	No	No	0	4	6
153	R:R:E364	R:R:I317	6.83	No	No	0	8	7
154	R:R:L360	R:R:N320	4.12	Yes	No	0	9	9
155	R:R:F321	R:R:V365	11.8	No	No	0	6	6
156	R:R:F324	R:R:I328	6.28	Yes	No	0	9	7
157	R:R:F324	R:R:L356	7.31	Yes	No	0	9	9
158	R:R:F324	R:R:I357	6.28	Yes	No	10	9	8
159	R:R:F324	R:R:T362	7.78	Yes	No	10	9	7
160	R:R:I330	R:R:R326	10.02	No	No	0	9	8
161	R:R:I328	R:R:T353	7.6	No	No	0	7	9
162	R:R:I345	R:R:L335	4.28	No	No	0	5	8
163	R:R:D344	R:R:K346	6.91	No	No	0	7	6
164	R:R:C347	W:W:?1	36.37	No	No	0	7	0
165	R:R:K351	R:R:R348	12.38	No	No	0	8	8
166	R:R:R348	R:R:S352	11.86	No	No	0	8	9
167	R:R:A350	W:W:?1	8.33	No	No	0	8	0
168	R:R:L401	R:R:T355	7.37	No	No	0	8	8
169	R:R:T355	R:R:Y402	6.24	No	No	0	8	8
170	R:R:L356	R:R:L360	5.54	No	Yes	0	9	9
171	R:R:I357	R:R:T362	7.6	No	No	10	8	7
172	R:R:H363	R:R:I357	3.98	No	No	0	8	8
173	R:R:L359	R:R:L360	4.15	No	Yes	0	9	9
174	R:R:L359	R:R:Y402	24.62	No	No	0	9	8
175	R:R:F390	R:R:H363	15.84	No	No	0	6	8
176	R:R:H363	R:R:Q394	8.65	No	No	0	8	9
177	R:R:E364	R:R:T391	5.64	No	No	0	8	6
178	R:R:F367	R:R:I366	8.79	No	No	0	7	6
179	R:R:F367	R:R:T386	10.38	No	No	0	7	4
180	R:R:E387	R:R:F367	7	No	No	0	8	7
181	R:R:E387	R:R:K383	6.75	No	No	0	8	7
182	R:R:F385	R:R:S389	7.93	No	No	0	6	5
183	R:R:F390	R:R:T386	6.49	No	No	0	6	4
184	R:R:F393	R:R:S392	5.28	No	No	0	7	9
185	R:R:I400	R:R:L396	4.28	No	No	0	6	7
186	R:R:C403	R:R:F404	4.19	Yes	Yes	0	9	8
187	R:R:E408	R:R:N406	10.52	No	No	0	9	9
188	R:R:K415	R:R:L411	7.05	No	No	0	7	4
189	R:R:E412	R:R:K415	10.8	Yes	No	1	8	7
190	R:R:E412	R:R:S416	4.31	Yes	No	1	8	5
191	R:R:E418	R:R:R421	6.98	No	No	0	4	4
192	R:R:E423	R:R:W420	7.63	No	No	0	4	4
193	R:R:S225	R:R:Y220	3.82	No	No	0	3	3
194	R:R:V249	R:R:Y269	3.79	No	No	0	6	7
195	R:R:F404	R:R:I161	3.77	Yes	No	0	8	4
196	R:R:F381	R:R:I382	3.77	No	No	0	4	4
197	R:R:F404	R:R:I400	3.77	Yes	No	0	8	6
198	R:R:W417	R:R:W420	3.75	No	No	0	5	4
199	R:R:A239	R:R:P277	3.74	No	No	0	8	9
200	R:R:G151	R:R:V150	3.68	No	No	0	8	5
201	R:R:L335	R:R:R348	3.64	No	No	0	8	8
202	R:R:L379	R:R:R376	3.64	No	No	0	3	5
203	R:R:P137	R:R:S136	3.56	No	No	0	3	1
204	R:R:P283	R:R:V282	3.53	No	No	0	5	3
205	R:R:P358	R:R:V398	3.53	No	No	0	9	9
206	R:R:L144	R:R:Y148	3.52	No	Yes	0	6	7
207	R:R:I308	R:R:W284	3.52	No	Yes	0	8	8
208	R:R:L218	R:R:W214	3.42	No	No	0	3	1
209	R:R:G285	R:R:L231	3.42	No	No	0	5	5
210	R:R:H173	R:R:R170	3.39	No	No	0	7	8
211	R:R:M397	R:R:P358	3.35	No	No	0	5	9
212	R:R:C403	R:R:I165	3.27	Yes	No	0	9	8
213	R:R:E418	R:R:W417	3.27	No	No	0	4	5
214	R:R:A238	R:R:I313	3.25	No	No	0	6	7
215	R:R:S352	R:R:V331	3.23	No	No	0	9	8
216	R:R:S206	R:R:T207	3.2	No	Yes	0	4	3
217	R:R:I146	R:R:V150	3.07	No	No	0	4	5
218	R:R:I323	R:R:V319	3.07	No	No	0	8	6
219	R:R:I400	R:R:V405	3.07	No	No	0	6	6
220	R:R:K336	R:R:V332	3.04	No	No	0	6	6
221	R:R:F187	R:R:G395	3.01	Yes	No	0	8	9
222	R:R:L181	R:R:S163	3	No	No	0	6	6
223	R:R:L231	R:R:V281	2.98	No	No	0	5	6
224	R:R:L349	R:R:V332	2.98	No	No	0	9	6
225	R:R:L217	R:R:T207	2.95	No	Yes	0	4	3
226	R:R:L349	R:R:T353	2.95	No	No	0	9	9
227	R:R:I330	R:R:K334	2.91	No	No	0	9	9
228	R:R:I345	R:R:K336	2.91	No	No	0	5	6
229	R:R:Q410	R:R:V405	2.87	No	No	0	7	6
230	R:R:Q213	R:R:T207	2.83	No	Yes	0	4	3
231	R:R:K383	R:R:L384	2.82	No	No	0	7	5
232	R:R:L154	R:R:L396	2.77	No	No	0	5	7
233	R:R:A158	R:R:F404	2.77	No	Yes	0	7	8
234	R:R:A375	R:R:R380	2.77	No	No	0	4	5
235	R:R:D222	R:R:L218	2.71	No	No	0	6	3
236	R:R:E138	R:R:L142	2.65	No	No	0	2	3
237	R:R:E418	R:R:L422	2.65	No	No	0	4	4
238	R:R:E292	R:R:N302	2.63	Yes	No	0	6	5
239	R:R:F369	R:R:V365	2.62	Yes	No	0	4	6
240	R:R:I313	R:R:R310	2.51	No	Yes	0	7	6
241	R:R:F369	R:R:I317	2.51	Yes	No	0	4	7
242	R:R:T149	R:R:Y148	2.5	No	Yes	0	7	7
243	R:R:F385	R:R:L144	2.44	No	No	0	6	6
244	R:R:L307	R:R:R310	2.43	No	Yes	0	7	6
245	R:R:C296	R:R:G295	1.96	No	No	0	9	4
246	R:R:G395	R:R:S155	1.86	No	No	0	9	9
247	R:R:A158	R:R:A399	1.79	No	No	0	7	8
248	R:R:A162	R:R:A399	1.79	No	No	0	9	8
249	R:R:G168	R:R:L167	1.71	No	No	0	1	3
250	R:R:C226	R:R:V229	1.71	No	No	0	9	7
251	R:R:I308	R:R:P283	1.69	No	No	0	8	5
252	R:R:C296	R:R:T298	1.69	No	No	0	9	5
253	R:R:A153	R:R:T149	1.68	No	No	0	6	7
254	R:R:A200	R:R:I196	1.62	No	No	0	4	5
255	R:R:C236	R:R:L232	1.59	No	No	0	5	5
256	R:R:A368	R:R:L314	1.58	No	No	0	6	4
257	R:R:A375	R:R:L379	1.58	No	No	0	4	3
258	R:R:C174	R:R:N177	1.57	No	No	0	8	9
259	R:R:I188	R:R:V160	1.54	No	No	0	7	3
260	R:R:I196	R:R:V229	1.54	No	No	0	5	7
261	R:R:K202	R:R:S206	1.53	No	No	0	4	4
262	R:R:K334	R:R:S333	1.53	No	No	0	9	7
263	R:R:F321	R:R:G318	1.51	No	No	0	6	4
264	R:R:F369	R:R:G318	1.51	Yes	No	0	4	4
265	R:R:D344	R:R:T343	1.45	No	No	0	7	5
266	R:R:K202	R:R:L201	1.41	No	No	0	4	7
267	R:R:C329	R:R:R326	1.39	No	No	0	7	8
268	R:R:A209	R:R:Y205	1.33	No	No	0	1	3
269	R:R:N407	R:R:Q410	1.32	No	No	0	6	7
270	R:R:R419	R:R:S416	1.32	No	No	0	7	5
271	R:R:A185	R:R:W274	1.3	No	Yes	0	3	9
272	R:R:Q210	R:R:Q211	1.28	No	No	0	4	4
273	R:R:Q210	R:R:Q213	1.28	No	No	0	4	4
274	R:R:E423	R:R:H424	1.23	No	No	0	4	4
275	R:R:L384	R:R:R380	1.21	No	No	0	5	5
276	R:R:M303	R:R:W306	1.16	No	No	0	5	6
277	R:R:F381	R:R:R380	1.07	No	No	0	4	5
278	R:R:R414	R:R:W417	1	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y148	6.56286	7	2	7
2	R:R:Y152	5.658	5	2	7
3	R:R:L166	5.9075	4	5	8
4	R:R:F169	12.0525	4	1	7
5	R:R:F184	5.622	5	5	8
6	R:R:F187	8.052	5	4	8
7	R:R:R190	7.0775	4	0	8
8	R:R:T207	4.065	4	0	3
9	R:R:R227	12.08	4	7	8
10	R:R:F230	8.05	4	6	5
11	R:R:Q234	6.79	4	6	7
12	R:R:Y242	6.50667	6	8	6
13	R:R:W243	10.75	7	3	9
14	R:R:L244	5.2575	4	4	9
15	R:R:E247	8.7525	4	0	9
16	R:R:Y250	6.985	4	0	8
17	R:R:F266	5.6	4	0	6
18	R:R:W274	9.754	5	3	9
19	R:R:W284	6.9825	4	6	8
20	R:R:E292	5.06	4	0	6
21	R:R:Y305	9.0025	4	9	4
22	R:R:R310	6.61	4	0	6
23	R:R:F324	6.9125	4	10	9
24	R:R:L360	4.735	4	0	9
25	R:R:F369	2.8775	4	0	4
26	R:R:C403	4.5	4	5	9
27	R:R:F404	3.625	4	0	8
28	R:R:E412	12.022	5	1	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:K383	R:R:L384	11.1241	2.82	No	No	0	7	5
2	R:R:E387	R:R:K383	12.4716	6.75	No	No	0	8	7
3	R:R:E387	R:R:F367	13.8074	7	No	No	0	8	7
4	R:R:F367	R:R:T386	16.444	10.38	No	No	0	7	4
5	R:R:F390	R:R:T386	17.7449	6.49	No	No	0	6	4
6	R:R:F390	R:R:H363	19.034	15.84	No	No	0	6	8
7	R:R:H363	R:R:Q394	17.6574	8.65	No	No	0	8	9
8	R:R:F187	R:R:Q394	18.3107	9.37	Yes	No	0	8	9
9	R:R:F187	R:R:N240	49.1046	16.92	Yes	No	4	8	9
10	R:R:N240	R:R:R190	88.4734	12.05	No	Yes	0	9	8
11	R:R:R190	R:R:Y152	45.4763	5.14	Yes	Yes	0	8	7
12	R:R:Y148	R:R:Y152	23.0765	3.97	Yes	Yes	2	7	7
13	R:R:S392	R:R:Y152	14.204	5.09	No	Yes	0	9	7
14	R:R:F393	R:R:S392	11.8649	5.28	No	No	0	7	9
15	R:R:F184	R:R:L166	17.5757	4.87	Yes	Yes	5	8	8
16	R:R:L166	R:R:N177	57.9712	5.49	Yes	No	0	8	9
17	R:R:N177	R:R:R176	60.6545	8.44	No	No	0	9	9
18	R:R:R176	R:R:Y250	64.522	4.12	No	Yes	0	9	8
19	R:R:T175	R:R:Y250	89.1443	7.49	No	Yes	0	7	8
20	R:R:F266	R:R:T175	91.2209	3.89	Yes	No	0	6	7
21	R:R:F266	R:R:I179	87.5634	5.02	Yes	No	0	6	8
22	R:R:E247	R:R:I179	100	5.47	Yes	No	0	9	8
23	R:R:E247	R:R:L183	96.6517	5.3	Yes	No	0	9	9
24	R:R:F187	R:R:L183	53.5612	6.09	Yes	No	4	8	9
25	R:R:C403	R:R:L166	33.4772	6.35	Yes	Yes	5	9	8
26	R:R:C403	R:R:I165	18.9057	3.27	Yes	No	0	9	8
27	R:R:F413	R:R:I165	17.2315	6.28	No	No	0	5	8
28	R:R:F169	R:R:F413	15.6274	9.65	Yes	No	0	7	5
29	R:R:I179	R:R:W243	21.4023	4.7	No	Yes	0	8	9
30	R:R:H363	R:R:I357	13.0082	3.98	No	No	0	8	8
31	R:R:F324	R:R:I357	12.7807	6.28	Yes	No	10	9	8
32	R:R:F324	R:R:L356	20.7082	7.31	Yes	No	0	9	9
33	R:R:L356	R:R:L360	21.7465	5.54	No	Yes	0	9	9
34	R:R:L359	R:R:L360	84.5243	4.15	No	Yes	0	9	9
35	R:R:E247	R:R:L359	86.1518	11.93	Yes	No	0	9	9
36	R:R:F266	R:R:V270	10.0332	5.24	Yes	No	0	6	5
37	R:R:W243	R:R:W274	16.094	24.37	Yes	Yes	3	9	9
38	R:R:I309	R:R:Q234	75.5119	8.23	No	Yes	0	7	7
39	R:R:F280	R:R:I309	76.5035	6.28	No	No	0	5	7
40	R:R:F280	R:R:Y242	77.0869	10.32	No	Yes	8	5	6
41	R:R:L245	R:R:Y242	84.8801	4.69	No	Yes	0	8	6
42	R:R:L245	R:R:N320	85.7551	5.49	No	No	0	8	9
43	R:R:L360	R:R:N320	86.6184	4.12	Yes	No	0	9	9
44	R:R:R190	R:R:Y241	43.5513	7.2	Yes	No	0	8	8
45	R:R:F230	R:R:Q234	11.9991	9.37	Yes	Yes	6	5	7
46	R:R:Q234	R:R:W284	55.9587	5.48	Yes	Yes	6	7	8
47	R:R:K288	R:R:W284	53.3046	13.92	No	Yes	0	8	8
48	R:R:K288	R:R:W297	40.4713	22.05	No	No	0	8	8
49	R:R:R227	R:R:W297	39.1238	21.99	Yes	No	0	8	8
50	R:R:E294	R:R:R227	35.0114	15.12	No	Yes	0	4	8
51	R:R:D222	R:R:E294	33.6172	9.09	No	No	0	6	4
52	R:R:D222	R:R:L218	32.2114	2.71	No	No	0	6	3
53	R:R:L218	R:R:W214	29.3648	3.42	No	No	0	3	1
54	R:R:D215	R:R:W214	27.9239	4.47	No	No	0	3	1
55	R:R:D215	R:R:Q213	25.0073	11.75	No	No	0	3	4
56	R:R:Q213	R:R:T207	20.5448	2.83	No	Yes	0	4	3
57	R:R:F230	R:R:T298	11.3574	10.38	Yes	No	0	5	5
58	R:R:W274	R:R:Y235	14.659	6.75	Yes	No	0	9	9
59	R:R:I313	R:R:Y241	23.0823	9.67	No	No	0	7	8
60	R:R:E364	R:R:Y241	18.4857	11.22	No	No	0	8	8
61	R:R:Y250	R:R:Y269	31.8031	6.95	Yes	No	0	8	7
62	R:R:I265	R:R:Y269	28.6531	10.88	No	No	0	5	7
63	R:R:I265	R:R:L260	27.0606	5.71	No	No	0	5	7
64	R:R:L260	R:R:T253	25.4565	5.9	No	No	0	7	7
65	R:R:F257	R:R:T253	23.8406	6.49	No	No	0	5	7
66	R:R:A256	R:R:F257	22.2131	8.32	No	No	0	6	5
67	R:R:A256	R:R:Y252	20.574	5.34	No	No	0	6	8
68	R:R:R326	R:R:Y252	13.9007	7.2	No	No	0	8	8
69	R:R:I330	R:R:R326	10.4941	10.02	No	No	0	9	8
70	R:R:E292	R:R:K288	14.4315	8.1	Yes	No	0	6	8
71	R:R:I313	R:R:R310	18.6023	2.51	No	Yes	0	7	6
72	R:R:F369	R:R:I317	11.6432	2.51	Yes	No	0	4	7
73	R:R:E364	R:R:I317	13.8891	6.83	No	No	0	8	7
74	R:R:F324	R:R:I328	14.8165	6.28	Yes	No	0	9	7
75	R:R:I328	R:R:T353	13.5157	7.6	No	No	0	7	9
76	R:R:L349	R:R:T353	12.2732	2.95	No	No	0	9	9
77	R:R:L349	R:R:V332	10.9491	2.98	No	No	0	9	6
78	R:R:C403	R:R:F404	15.5982	4.19	Yes	Yes	0	9	8
79	R:R:F404	R:R:I400	10.5291	3.77	Yes	No	0	8	6
80	R:R:L183	R:R:L244	42.7405	5.54	No	Yes	4	9	9
81	R:R:L244	R:R:N240	41.2822	5.49	Yes	No	4	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:C347	W:W:?1	36.37	0	No	No	7	0	1	0
R:R:A350	W:W:?1	8.33	0	No	No	8	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7EVM_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.89
Number of Linked Nodes	260
Number of Links	278
Number of Hubs	28
Number of Links mediated by Hubs	113
Number of Communities	10
Number of Nodes involved in Communities	38
Number of Links involved in Communities	45

Path Summary
Number Of Nodes in MetaPath	82
Number Of Links MetaPath	81
Number of Shortest Paths	37724
Length Of Smallest Path	3
Average Path Length	16.7072
Length of Longest Path	41
Minimum Path Strength	1.14
Average Path Strength	7.12414
Maximum Path Strength	22.35
Minimum Path Correlation	0.71
Average Path Correlation	0.942838
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	53.9327
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.1065
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • cell projection membrane • synapse • cell junction • cell body • glucagon receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • amide binding • peptide hormone binding • hormone binding • glucagon-like peptide 1 receptor activity • heart process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • regulation of blood pressure • positive regulation of blood pressure • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to psychosocial stress • cell surface receptor signaling pathway • behavior • learning or memory • cognition • transport • secretion • regulation of hormone levels • cell-cell signaling • export from cell • hormone secretion • establishment of localization • localization • secretion by cell • signal release • hormone transport • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • protein localization • establishment of protein localization • cellular localization • nitrogen compound transport • protein targeting • protein transmembrane transport • cellular macromolecule localization • establishment of localization in cell • post-translational protein targeting to membrane, translocation • establishment of protein localization to endoplasmic reticulum • protein localization to endoplasmic reticulum • establishment of protein localization to membrane • intracellular protein transmembrane transport • intracellular transport • post-translational protein targeting to endoplasmic reticulum membrane • localization within membrane • protein localization to membrane • protein targeting to membrane • transmembrane transport • establishment of protein localization to organelle • protein transport • macromolecule localization • protein localization to organelle • intracellular protein transport • protein targeting to ER • negative regulation of blood pressure • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HNO
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	HNO
Name	N-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine
Synonyms
Identifier
Formula	C12 H13 Cl2 N3
Molecular Weight	270.158
SMILES
PubChem	156022738
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	0
Total Bonds	31
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43220
Sequence	>7EVM_nogp_Chain_R S P E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F R H L H C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S T A A Q Q H Q W D G L L S Y Q D S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S V L S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E D E G C W T R N S N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L T D I K C R L A K S T L T L I P L L G T H E V I F A F V A R G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E V Q L E F R K S W E R W R L E H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9IVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839	chim(NtGi1-Gs)/β2/γ2	3.22	2024-11-13	10.1016/j.apsb.2024.09.002
	9IVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839		3.22	2024-11-13	10.1016/j.apsb.2024.09.002
	8YW3	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8WG7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.54	2024-03-06	10.1038/s41421-024-00649-0
	8WG7 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.54	2024-03-06	10.1038/s41421-024-00649-0
	8JIS	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-	chim(NtGi1-Gs)/β1/γ2	2.46	2023-11-08	10.1073/pnas.2303696120
	8JIS (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-		2.46	2023-11-08	10.1073/pnas.2303696120
	8JIR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-	chim(NtGi1-Gs)/β1/γ2	2.57	2023-09-06	10.1073/pnas.2303696120
	8JIR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-		2.57	2023-09-06	10.1073/pnas.2303696120
	8JIP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-	chim(NtGi1-Gs)/β1/γ2	2.85	2023-09-06	10.1073/pnas.2303696120
	8JIP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-		2.85	2023-09-06	10.1073/pnas.2303696120
	9IVG	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	chim(NtGi1-Gs)/β1/γ2	3	2024-11-27	10.1016/j.apsb.2024.09.002
	9IVG (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-		3	2024-11-27	10.1016/j.apsb.2024.09.002
	9J1P	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-	chim(NtGi1-Gs)/β1/γ2	2.99	2025-02-26	10.1021/jacs.4c12808
	9J1P (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-		2.99	2025-02-26	10.1021/jacs.4c12808
	7X8S	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-	Gs/β1/γ2	3.09	2022-06-29	10.1073/pnas.2200155119
	7X8S (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-		3.09	2022-06-29	10.1073/pnas.2200155119
	7X8R	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-	Gs/β1/γ2	2.61	2022-06-29	10.1073/pnas.2200155119
	7X8R (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-		2.61	2022-06-29	10.1073/pnas.2200155119
	7S15	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 134611223	-	-	3.8	2022-06-08	10.1021/acs.jmedchem.1c01856
	7RGP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2022-04-13	10.1073/pnas.2116506119
	7RGP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		2.9	2022-04-13	10.1073/pnas.2116506119
	7RG9	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-04-13	10.1073/pnas.2116506119
	7RG9 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.2	2022-04-13	10.1073/pnas.2116506119
	7VBH	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3	2022-04-06	10.1038/s41467-022-28683-0
	7VBH (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-		3	2022-04-06	10.1038/s41467-022-28683-0
	7VBI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-	Gs/β1/γ2	3	2022-03-02	10.1038/s41467-022-28683-0
	7VBI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-		3	2022-03-02	10.1038/s41467-022-28683-0
	7FIM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	10.1038/s41467-022-28683-0
	7FIM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	10.1038/s41467-022-28683-0
	7LLY	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-	Gs/β1/γ2	3.3	2022-01-12	10.1038/s41467-021-27760-0
	7LLY (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-		3.3	2022-01-12	10.1038/s41467-021-27760-0
	7LLL	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	3.7	2022-01-12	10.1038/s41467-021-27760-0
	7LLL (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		3.7	2022-01-12	10.1038/s41467-021-27760-0
	7S3I	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.51	2022-01-05	10.1038/s41589-021-00945-w
	7S3I (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.51	2022-01-05	10.1038/s41589-021-00945-w
	7S1M	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-	Gs/β1/γ2	2.41	2022-01-05	10.1038/s41589-021-00945-w
	7S1M (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-		2.41	2022-01-05	10.1038/s41589-021-00945-w
	7RTB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-	Gs/β1/γ2	2.14	2021-10-06	10.1016/j.bbrc.2021.09.016
	7RTB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-		2.14	2021-10-06	10.1016/j.bbrc.2021.09.016
	7EVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	2.5	2021-08-11	10.1038/s41467-021-24058-z
	7EVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		2.5	2021-08-11	10.1038/s41467-021-24058-z
	7DUR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	3.3	2021-08-11	10.1038/s41467-021-24058-z
	7DUR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		3.3	2021-08-11	10.1038/s41467-021-24058-z
	7KI1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-	Gs/β1/γ2	2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI1 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-		2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI0	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-	Gs/β1/γ2	2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI0 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-		2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7DUQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738	Gs/β1/γ2	2.5	2021-07-14	10.1038/s41467-021-24058-z
	7DUQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738		2.5	2021-07-14	10.1038/s41467-021-24058-z
	7E14	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738	Gs/β1/γ2	2.9	2021-07-07	10.1038/s41467-021-24058-z
	7E14 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738		2.9	2021-07-07	10.1038/s41467-021-24058-z
	7LCK	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	3.24	2021-01-20	10.1016/j.str.2021.04.008
	7LCJ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	2.82	2021-01-20	10.1016/j.str.2021.04.008
	7LCI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.9	2021-01-20	10.1016/j.str.2021.04.008
	7LCI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.9	2021-01-20	10.1016/j.str.2021.04.008
	6XOX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-	chim(NtGi1-Gs)/β1/γ2	3.1	2020-11-18	10.1073/pnas.2014879117
	6XOX (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-		3.1	2020-11-18	10.1073/pnas.2014879117
	6X1A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.5	2020-09-09	10.1016/j.molcel.2020.09.020
	6X1A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.5	2020-09-09	10.1016/j.molcel.2020.09.020
	6X19	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-	Gs/β1/γ2	2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X19 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-		2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X18	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X18 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	7C2E	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-	Gs/β1/γ2	4.2	2020-08-26	10.1038/s41422-020-0384-8
	7C2E (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-		4.2	2020-08-26	10.1038/s41422-020-0384-8
	6VCB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440	Gs/β1/γ2	3.3	2020-07-22	10.1038/s41589-020-0589-7
	6VCB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440		3.3	2020-07-22	10.1038/s41589-020-0589-7
	6LN2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	3.2	2020-03-18	10.1038/s41467-020-14934-5
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	10.1038/s41586-019-1902-z
	6KK7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	3.1	2019-11-13	10.1107/S2052252519013496
	6KK1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	2.8	2019-11-13	10.1107/S2052252519013496
	6KJV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	2.8	2019-11-13	10.1107/S2052252519013496
	6B3J	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-	Gs/β1/γ2	3.3	2018-02-21	10.1038/nature25773
	6B3J (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-		3.3	2018-02-21	10.1038/nature25773
	5NX2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	-	3.7	2017-06-14	10.1038/nature22800
	5VEW	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.7	2017-05-24	10.1038/nature22378
	5VAI	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-	Gs/β1/γ2	4.1	2017-05-24	10.1038/nature22394
	5VAI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-		4.1	2017-05-24	10.1038/nature22394
	5VEX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	NNC0640	-	3	2017-05-17	10.1038/nature22378

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