psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P137	R:R:S136	3.56	No	No	0	3	1
2	R:R:E139	R:R:S136	10.06	No	No	0	2	1
3	R:R:E138	R:R:P137	3.14	No	No	0	2	3
4	R:R:E139	R:R:L142	3.98	No	No	0	2	3
5	R:R:F385	R:R:L144	14.61	Yes	No	0	6	6
6	R:R:T149	R:R:Y145	11.24	No	No	0	7	5
7	R:R:D198	R:R:Y145	9.2	No	No	0	7	5
8	R:R:Y148	R:R:Y152	19.86	Yes	Yes	4	7	7
9	R:R:V194	R:R:Y148	6.31	No	Yes	4	7	7
10	R:R:S392	R:R:Y148	5.09	Yes	Yes	4	9	7
11	R:R:G151	R:R:S392	3.71	No	Yes	4	8	9
12	R:R:F393	R:R:G151	9.03	No	No	4	7	8
13	R:R:R190	R:R:Y152	5.14	Yes	Yes	0	8	7
14	R:R:V194	R:R:Y152	10.09	No	Yes	4	7	7
15	R:R:S392	R:R:Y152	3.82	Yes	Yes	4	9	7
16	R:R:G395	R:R:S155	3.71	No	No	0	9	9
17	R:R:L396	R:R:S155	3	Yes	No	0	7	9
18	R:R:F156	R:R:V160	6.55	Yes	No	5	7	3
19	R:R:F156	R:R:I188	3.77	Yes	Yes	5	7	7
20	R:R:F156	R:R:L192	6.09	Yes	No	0	7	3
21	R:R:F156	R:R:F195	4.29	Yes	No	5	7	7
22	R:R:F184	R:R:L159	4.87	No	No	0	8	9
23	R:R:I188	R:R:L159	5.71	Yes	No	0	7	9
24	R:R:A399	R:R:L159	3.15	No	No	0	8	9
25	R:R:I188	R:R:V160	3.07	Yes	No	5	7	3
26	R:R:A162	R:R:C403	3.61	No	No	0	9	9
27	R:R:F169	R:R:I165	5.02	Yes	Yes	1	7	8
28	R:R:C403	R:R:I165	4.91	No	Yes	0	9	8
29	R:R:F413	R:R:I165	7.54	No	Yes	1	5	8
30	R:R:L166	R:R:N177	10.98	No	Yes	0	8	9
31	R:R:L166	R:R:L181	6.92	No	No	0	8	6
32	R:R:F184	R:R:L166	4.87	No	No	0	8	8
33	R:R:L167	R:R:L181	6.92	No	No	0	3	6
34	R:R:F169	R:R:L172	4.87	Yes	Yes	1	7	9
35	R:R:E412	R:R:F169	8.16	Yes	Yes	1	8	7
36	R:R:F169	R:R:F413	3.22	Yes	No	1	7	5
37	R:R:E412	R:R:H171	12.31	Yes	No	1	8	7
38	R:R:H171	R:R:K415	9.17	No	No	1	7	7
39	R:R:L172	R:R:N177	4.12	Yes	Yes	1	9	9
40	R:R:L172	R:R:V409	4.47	Yes	No	0	9	9
41	R:R:E412	R:R:L172	3.98	Yes	Yes	1	8	9
42	R:R:H173	R:R:Y178	8.71	No	No	0	7	6
43	R:R:C174	R:R:R176	5.57	No	Yes	1	8	9
44	R:R:C174	R:R:N177	4.72	No	Yes	1	8	9
45	R:R:T175	R:R:Y250	4.99	No	Yes	0	7	8
46	R:R:N177	R:R:R176	9.64	Yes	Yes	1	9	9
47	R:R:H180	R:R:R176	5.64	Yes	Yes	1	9	9
48	R:R:R176	R:R:Y250	4.12	Yes	Yes	0	9	8
49	R:R:H180	R:R:N177	3.83	Yes	Yes	1	9	9
50	R:R:I179	R:R:W243	4.7	No	Yes	0	8	9
51	R:R:E247	R:R:I179	5.47	No	No	0	9	8
52	R:R:I179	R:R:Y250	6.04	No	Yes	0	8	8
53	R:R:E247	R:R:H180	9.85	No	Yes	1	9	9
54	R:R:H180	R:R:Y402	25.04	Yes	Yes	1	9	8
55	R:R:N182	R:R:W243	21.47	No	Yes	8	9	9
56	R:R:N182	R:R:W274	6.78	No	Yes	8	9	9
57	R:R:F187	R:R:L183	3.65	Yes	No	6	8	9
58	R:R:L183	R:R:V398	2.98	No	No	6	9	9
59	R:R:N240	R:R:S186	7.45	No	No	0	9	9
60	R:R:F187	R:R:N240	19.33	Yes	No	0	8	9
61	R:R:F187	R:R:Q394	5.86	Yes	Yes	0	8	9
62	R:R:F187	R:R:G395	4.52	Yes	No	6	8	9
63	R:R:F187	R:R:V398	3.93	Yes	No	6	8	9
64	R:R:C236	R:R:L189	4.76	No	No	0	5	7
65	R:R:R190	R:R:V237	6.54	Yes	No	0	8	6
66	R:R:N240	R:R:R190	9.64	No	Yes	0	9	8
67	R:R:Q394	R:R:R190	4.67	Yes	Yes	0	9	8
68	R:R:L232	R:R:S193	4.5	No	No	0	5	6
69	R:R:M233	R:R:S193	6.13	No	No	0	6	6
70	R:R:M233	R:R:V194	3.04	No	No	0	6	7
71	R:R:I196	R:R:V229	4.61	No	No	0	5	7
72	R:R:K197	R:R:Y220	3.58	No	Yes	0	6	3
73	R:R:D198	R:R:L201	4.07	No	No	0	7	7
74	R:R:A200	R:R:Y220	6.67	No	Yes	0	4	3
75	R:R:K202	R:R:W203	3.48	No	No	0	4	3
76	R:R:S223	R:R:Y220	3.82	No	Yes	0	4	3
77	R:R:C226	R:R:Y220	16.13	No	Yes	0	9	3
78	R:R:V229	R:R:Y220	3.79	No	Yes	0	7	3
79	R:R:G295	R:R:Q221	3.29	No	No	0	4	4
80	R:R:C226	R:R:C296	7.28	No	No	0	9	9
81	R:R:D293	R:R:R227	19.06	No	No	0	7	8
82	R:R:G295	R:R:R227	3	No	No	0	4	8
83	R:R:F230	R:R:Q234	7.03	No	No	2	5	7
84	R:R:F230	R:R:W284	8.02	No	Yes	2	5	8
85	R:R:L231	R:R:V281	2.98	No	No	0	5	6
86	R:R:C236	R:R:L232	3.17	No	No	0	5	5
87	R:R:Q234	R:R:W284	6.57	No	Yes	2	7	8
88	R:R:I309	R:R:Q234	6.86	No	No	2	7	7
89	R:R:W274	R:R:Y235	8.68	Yes	No	0	9	9
90	R:R:V281	R:R:Y235	5.05	No	No	0	6	9
91	R:R:A238	R:R:P277	3.74	No	No	0	6	9
92	R:R:A238	R:R:F280	4.16	No	Yes	0	6	5
93	R:R:A239	R:R:W274	3.89	No	Yes	0	8	9
94	R:R:I313	R:R:Y241	8.46	No	No	0	7	8
95	R:R:I272	R:R:Y242	4.84	No	Yes	9	6	6
96	R:R:V276	R:R:Y242	5.05	No	Yes	9	3	6
97	R:R:P277	R:R:Y242	5.56	No	Yes	0	9	6
98	R:R:F280	R:R:Y242	5.16	Yes	Yes	0	5	6
99	R:R:A316	R:R:Y242	5.34	No	Yes	0	7	6
100	R:R:V246	R:R:W243	3.68	No	Yes	0	8	9
101	R:R:V270	R:R:W243	6.13	No	Yes	0	5	9
102	R:R:G273	R:R:W243	8.44	No	Yes	0	9	9
103	R:R:W243	R:R:W274	18.74	Yes	Yes	8	9	9
104	R:R:L244	R:R:N320	5.49	No	No	0	9	9
105	R:R:L245	R:R:V249	2.98	No	No	0	8	6
106	R:R:L245	R:R:V319	4.47	No	No	0	8	6
107	R:R:L245	R:R:N320	10.98	No	No	0	8	9
108	R:R:V246	R:R:Y269	10.09	No	No	0	8	7
109	R:R:E247	R:R:Y402	14.59	No	Yes	1	9	8
110	R:R:V249	R:R:Y269	3.79	No	No	0	6	7
111	R:R:L254	R:R:Y250	3.52	No	Yes	0	8	8
112	R:R:L251	R:R:V327	2.98	Yes	Yes	0	9	9
113	R:R:L251	R:R:L349	6.92	Yes	No	0	9	9
114	R:R:A350	R:R:L251	4.73	No	Yes	0	8	9
115	R:R:L251	R:R:T353	4.42	Yes	Yes	0	9	9
116	R:R:L255	R:R:V327	4.47	No	Yes	0	8	9
117	R:R:I330	R:R:L255	4.28	No	No	0	9	8
118	R:R:L255	R:R:V331	2.98	No	No	0	8	8
119	R:R:E262	R:R:W264	10.9	No	Yes	10	6	5
120	R:R:E262	R:R:I265	4.1	No	No	10	6	5
121	R:R:I265	R:R:W264	14.09	No	Yes	10	5	5
122	R:R:I265	R:R:Y269	4.84	No	No	0	5	7
123	R:R:F266	R:R:V270	7.87	No	No	0	6	5
124	R:R:L268	R:R:S271	3	No	No	0	2	3
125	R:R:I272	R:R:V276	7.68	No	No	9	6	3
126	R:R:L278	R:R:V282	2.98	No	No	0	3	3
127	R:R:F280	R:R:I309	5.02	Yes	No	0	5	7
128	R:R:F280	R:R:P312	17.34	Yes	No	0	5	8
129	R:R:P283	R:R:V282	5.3	No	No	0	5	3
130	R:R:K288	R:R:W284	16.24	Yes	Yes	2	8	8
131	R:R:N300	R:R:W284	3.39	Yes	Yes	2	6	8
132	R:R:I308	R:R:W284	4.7	No	Yes	0	8	8
133	R:R:I309	R:R:W284	10.57	No	Yes	2	7	8
134	R:R:V287	R:R:Y305	12.62	No	Yes	0	4	4
135	R:R:E292	R:R:K288	5.4	Yes	Yes	2	6	8
136	R:R:K288	R:R:W297	18.57	Yes	Yes	2	8	8
137	R:R:K288	R:R:N300	8.39	Yes	Yes	2	8	6
138	R:R:D293	R:R:Y289	3.45	No	No	0	7	3
139	R:R:L290	R:R:Y291	9.38	No	No	0	3	3
140	R:R:Y291	R:R:Y305	4.96	No	Yes	0	3	4
141	R:R:E292	R:R:W297	23.99	Yes	Yes	2	6	8
142	R:R:E292	R:R:N302	11.83	Yes	No	0	6	5
143	R:R:E292	R:R:Y305	12.35	Yes	Yes	0	6	4
144	R:R:E294	R:R:W297	7.63	No	Yes	0	4	8
145	R:R:R299	R:R:W297	5	No	Yes	0	4	8
146	R:R:N300	R:R:W297	7.91	Yes	Yes	2	6	8
147	R:R:N300	R:R:W306	16.95	Yes	No	0	6	6
148	R:R:M371	R:R:S301	6.13	No	No	0	7	3
149	R:R:M303	R:R:N302	4.21	No	No	0	5	5
150	R:R:M303	R:R:Y305	7.18	No	Yes	0	5	4
151	R:R:L307	R:R:N304	4.12	No	No	0	7	3
152	R:R:R310	R:R:W306	14.99	No	No	0	6	6
153	R:R:M371	R:R:W306	3.49	No	No	0	7	6
154	R:R:L307	R:R:L311	4.15	No	No	0	7	4
155	R:R:E364	R:R:R310	6.98	No	No	0	8	6
156	R:R:L311	R:R:P312	3.28	No	No	0	4	8
157	R:R:E364	R:R:I313	5.47	No	No	0	8	7
158	R:R:C317	R:R:C361	7.28	No	No	0	7	9
159	R:R:C317	R:R:E364	3.04	No	No	0	7	8
160	R:R:C361	R:R:N320	4.72	No	No	0	9	9
161	R:R:F321	R:R:F324	5.36	Yes	Yes	7	6	9
162	R:R:F321	R:R:I357	5.02	Yes	Yes	7	6	8
163	R:R:F321	R:R:P358	8.67	Yes	No	7	6	9
164	R:R:C361	R:R:F321	4.19	No	Yes	0	9	6
165	R:R:F324	R:R:I328	6.28	Yes	No	0	9	7
166	R:R:F324	R:R:L354	10.96	Yes	No	0	9	8
167	R:R:F324	R:R:I357	6.28	Yes	Yes	7	9	8
168	R:R:F324	R:R:P358	10.11	Yes	No	7	9	9
169	R:R:C329	R:R:R326	5.57	No	No	0	7	8
170	R:R:L354	R:R:V327	4.47	No	Yes	0	8	9
171	R:R:L335	R:R:V331	4.47	No	No	0	8	8
172	R:R:M340	R:R:V331	4.56	No	No	0	5	8
173	R:R:S333	R:R:V332	3.23	No	No	0	7	6
174	R:R:K334	R:R:L339	4.23	No	No	0	9	7
175	R:R:F347	R:R:L335	6.09	Yes	No	0	7	8
176	R:R:A337	R:R:L339	4.73	No	No	0	7	7
177	R:R:D344	R:R:M340	5.54	No	No	0	7	5
178	R:R:F347	R:R:M340	4.98	Yes	No	0	7	5
179	R:R:F347	R:R:K342	18.61	Yes	No	3	7	5
180	R:R:K342	W:W:?1	3.8	No	Yes	3	5	0
181	R:R:I345	R:R:R348	5.01	No	Yes	3	5	8
182	R:R:E408	R:R:I345	4.1	No	No	3	9	5
183	R:R:F347	R:R:K351	6.2	Yes	No	3	7	8
184	R:R:F347	W:W:?1	11.5	Yes	Yes	3	7	0
185	R:R:N407	R:R:R348	12.05	No	Yes	0	6	8
186	R:R:E408	R:R:R348	10.47	No	Yes	3	9	8
187	R:R:R348	W:W:?1	11.47	Yes	Yes	3	8	0
188	R:R:L349	R:R:Y402	3.52	No	Yes	0	9	8
189	R:R:A350	R:R:L354	3.15	No	No	0	8	8
190	R:R:K351	W:W:?1	35.19	No	Yes	3	8	0
191	R:R:L401	R:R:S352	7.51	Yes	No	0	8	9
192	R:R:S352	R:R:Y402	6.36	No	Yes	0	9	8
193	R:R:S352	W:W:?1	4.05	No	Yes	0	9	0
194	R:R:I357	R:R:T353	3.04	Yes	Yes	0	8	9
195	R:R:T353	R:R:Y402	8.74	Yes	Yes	0	9	8
196	R:R:L401	R:R:T355	4.42	Yes	No	0	8	8
197	R:R:T355	W:W:?1	3.98	No	Yes	0	8	0
198	R:R:L356	R:R:L401	4.15	No	Yes	0	9	8
199	R:R:L356	R:R:Y402	5.86	No	Yes	0	9	8
200	R:R:I357	R:R:P358	5.08	Yes	No	7	8	9
201	R:R:L359	R:R:L360	4.15	No	No	0	9	9
202	R:R:L359	R:R:M397	5.65	No	No	0	9	5
203	R:R:L360	R:R:Q394	13.31	No	Yes	0	9	9
204	R:R:I366	R:R:T362	4.56	No	No	0	6	7
205	R:R:F367	R:R:H363	14.71	No	No	0	7	8
206	R:R:E387	R:R:H363	6.15	No	No	0	8	8
207	R:R:F367	R:R:I366	15.07	No	No	0	7	6
208	R:R:L384	R:R:R380	3.64	No	No	0	5	5
209	R:R:F381	R:R:F385	9.65	No	Yes	0	4	6
210	R:R:K383	R:R:T386	3	No	No	0	7	4
211	R:R:E387	R:R:K383	18.9	No	No	0	8	7
212	R:R:Q394	R:R:T391	7.09	Yes	No	0	9	6
213	R:R:F393	R:R:S392	3.96	No	Yes	4	7	9
214	R:R:F393	R:R:L396	3.65	No	Yes	0	7	7
215	R:R:G395	R:R:V398	3.68	No	No	6	9	9
216	R:R:I400	R:R:L396	4.28	No	Yes	0	6	7
217	R:R:F404	R:R:I400	7.54	No	No	0	8	6
218	R:R:V405	W:W:?1	8.04	No	Yes	0	6	0
219	R:R:E408	R:R:N406	13.15	No	No	0	9	9
220	R:R:N406	R:R:V409	10.35	No	No	0	9	9
221	R:R:N406	W:W:?1	3.7	No	Yes	0	9	0
222	R:R:E412	R:R:K415	8.1	Yes	No	1	8	7
223	R:R:R414	R:R:W417	23.99	No	No	0	6	5
224	R:R:K415	R:R:R419	6.19	No	No	0	7	7
225	R:R:I161	R:R:I165	2.94	No	Yes	0	4	8
226	R:R:I330	R:R:K334	2.91	No	No	0	9	9
227	R:R:I318	R:R:L314	2.85	No	No	0	4	4
228	R:R:I318	R:R:L322	2.85	No	No	0	4	5
229	R:R:I400	R:R:L401	2.85	No	Yes	0	6	8
230	R:R:G285	R:R:W284	2.81	No	Yes	0	5	8
231	R:R:L154	R:R:L396	2.77	No	Yes	0	5	7
232	R:R:A191	R:R:F156	2.77	No	Yes	5	7	7
233	R:R:A158	R:R:F404	2.77	No	No	0	7	8
234	R:R:A191	R:R:F195	2.77	No	No	5	7	7
235	R:R:L224	R:R:L228	2.77	No	No	0	3	4
236	R:R:F390	R:R:S389	2.64	No	No	0	6	5
237	R:R:F321	R:R:V365	2.62	Yes	No	0	6	6
238	R:R:F367	R:R:V370	2.62	No	No	0	7	5
239	R:R:A185	R:R:W274	2.59	No	Yes	0	3	9
240	R:R:R299	R:R:T298	2.59	No	No	0	4	5
241	R:R:F143	R:R:I147	2.51	No	No	0	4	6
242	R:R:F381	R:R:I382	2.51	No	No	0	4	4
243	R:R:F369	R:R:L307	2.44	No	No	0	4	7
244	R:R:L388	R:R:Y148	2.34	No	Yes	0	7	7
245	R:R:L181	R:R:Y178	2.34	No	No	0	6	6
246	R:R:L224	R:R:Y289	2.34	No	No	0	3	3
247	R:R:L278	R:R:Y235	2.34	No	No	0	3	9
248	R:R:E418	R:R:R414	2.33	No	No	0	4	6
249	R:R:L268	R:R:W264	2.28	No	Yes	0	2	5
250	R:R:H173	R:R:R170	2.26	No	No	0	7	8
251	R:R:R326	R:R:Y252	2.06	No	No	0	8	8
252	R:R:G275	R:R:P277	2.03	No	No	0	6	9
253	R:R:R421	R:R:W420	2	No	No	0	4	4
254	R:R:G151	R:R:V150	1.84	No	No	0	8	5
255	R:R:G248	R:R:T353	1.82	No	Yes	0	8	9
256	R:R:G295	R:R:T298	1.82	No	No	0	4	5
257	R:R:G248	R:R:I323	1.76	No	No	0	8	8
258	R:R:G168	R:R:L167	1.71	No	No	0	1	3
259	R:R:C341	R:R:T343	1.69	No	No	0	4	5
260	R:R:S193	R:R:V229	1.62	No	No	0	6	7
261	R:R:A346	R:R:I345	1.62	No	No	0	6	5
262	R:R:T149	R:R:V150	1.59	No	No	0	7	5
263	R:R:A368	R:R:L314	1.58	No	No	0	6	4
264	R:R:C341	R:R:D344	1.56	No	No	0	4	7
265	R:R:I147	R:R:S389	1.55	No	No	0	6	5
266	R:R:I188	R:R:S163	1.55	Yes	No	0	7	6
267	R:R:I146	R:R:V150	1.54	No	No	0	4	5
268	R:R:I328	R:R:V332	1.54	No	No	0	7	6
269	R:R:L322	R:R:V319	1.49	No	No	0	5	6
270	R:R:I147	R:R:L144	1.43	No	No	0	6	6
271	R:R:I286	R:R:L290	1.43	No	No	0	4	3
272	R:R:Q410	R:R:V405	1.43	No	No	0	7	6
273	R:R:Q410	R:R:V409	1.43	No	No	0	7	9
274	R:R:F156	R:R:S157	1.32	Yes	No	0	7	3
275	R:R:F169	R:R:S416	1.32	Yes	No	0	7	5
276	R:R:D222	R:R:Q221	1.31	No	No	0	6	4
277	R:R:F315	R:R:V319	1.31	No	No	0	4	6
278	R:R:F324	R:R:V325	1.31	Yes	No	0	9	5
279	R:R:F321	R:R:T362	1.3	Yes	No	0	6	7
280	R:R:F385	R:R:T386	1.3	Yes	No	0	6	4
281	R:R:V327	R:R:Y252	1.26	Yes	No	0	9	8
282	R:R:T253	R:R:Y252	1.25	No	No	0	7	8
283	R:R:F143	R:R:L142	1.22	No	No	0	4	3
284	R:R:F385	R:R:Q140	1.17	Yes	No	0	6	4
285	R:R:Q263	R:R:W264	1.1	No	Yes	0	5	5
286	R:R:R421	R:R:W417	1	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y148	8.4	4	4	7
2	R:R:Y152	9.7275	4	4	7
3	R:R:F156	4.13167	6	5	7
4	R:R:I165	5.1025	4	1	8
5	R:R:F169	4.518	5	1	7
6	R:R:L172	4.36	4	1	9
7	R:R:R176	6.2425	4	1	9
8	R:R:N177	6.658	5	1	9
9	R:R:H180	11.09	4	1	9
10	R:R:F187	7.458	5	6	8
11	R:R:I188	3.525	4	5	7
12	R:R:R190	6.4975	4	0	8
13	R:R:Y220	6.798	5	0	3
14	R:R:Y242	5.19	5	9	6
15	R:R:W243	10.5267	6	8	9
16	R:R:Y250	4.6675	4	0	8
17	R:R:L251	4.7625	4	0	9
18	R:R:W264	7.0925	4	10	5
19	R:R:W274	8.136	5	8	9
20	R:R:F280	7.92	4	0	5
21	R:R:W284	7.47143	7	2	8
22	R:R:K288	12.15	4	2	8
23	R:R:E292	13.3925	4	2	6
24	R:R:W297	12.62	5	2	8
25	R:R:N300	9.16	4	2	6
26	R:R:Y305	9.2775	4	0	4
27	R:R:F321	4.52667	6	7	6
28	R:R:F324	6.71667	6	7	9
29	R:R:V327	3.295	4	0	9
30	R:R:F347	9.476	5	3	7
31	R:R:R348	9.75	4	3	8
32	R:R:T353	4.505	4	0	9
33	R:R:I357	4.855	4	7	8
34	R:R:F385	6.6825	4	0	6
35	R:R:S392	4.145	4	4	9
36	R:R:Q394	7.7325	4	0	9
37	R:R:L396	3.425	4	0	7
38	R:R:L401	4.7325	4	0	8
39	R:R:Y402	10.685	6	1	8
40	R:R:E412	8.1375	4	1	8
41	W:W:?1	10.2163	8	3	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F385	R:R:L144	10.9564	14.61	Yes	No	0	6	6
2	R:R:F385	R:R:T386	15.1054	1.3	Yes	No	0	6	4
3	R:R:K383	R:R:T386	16.1444	3	No	No	0	7	4
4	R:R:E387	R:R:K383	17.1765	18.9	No	No	0	8	7
5	R:R:E387	R:R:H363	18.117	6.15	No	No	0	8	8
6	R:R:F367	R:R:H363	19.1424	14.71	No	No	0	7	8
7	R:R:F367	R:R:I366	21.1591	15.07	No	No	0	7	6
8	R:R:I366	R:R:T362	22.1573	4.56	No	No	0	6	7
9	R:R:F321	R:R:T362	23.1487	1.3	Yes	No	0	6	7
10	R:R:F321	R:R:I357	62.8085	5.02	Yes	Yes	7	6	8
11	R:R:I357	R:R:T353	68.1357	3.04	Yes	Yes	0	8	9
12	R:R:T353	R:R:Y402	78.0701	8.74	Yes	Yes	0	9	8
13	R:R:S352	R:R:Y402	52.4599	6.36	No	Yes	0	9	8
14	R:R:L401	R:R:S352	51.336	7.51	Yes	No	0	8	9
15	R:R:I400	R:R:L401	100	2.85	No	Yes	0	6	8
16	R:R:I400	R:R:L396	95.5488	4.28	No	Yes	0	6	7
17	R:R:F393	R:R:L396	70.8077	3.65	No	Yes	0	7	7
18	R:R:F393	R:R:G151	11.8935	9.03	No	No	4	7	8
19	R:R:G151	R:R:V150	11.1058	1.84	No	No	0	8	5
20	R:R:L356	R:R:Y402	43.0007	5.86	No	Yes	0	9	8
21	R:R:L356	R:R:L401	42.5967	4.15	No	Yes	0	9	8
22	R:R:F393	R:R:S392	57.3592	3.96	No	Yes	4	7	9
23	R:R:S392	R:R:Y148	27.4064	5.09	Yes	Yes	4	9	7
24	R:R:S392	R:R:Y152	29.4367	3.82	Yes	Yes	4	9	7
25	R:R:V194	R:R:Y148	24.0349	6.31	No	Yes	4	7	7
26	R:R:V194	R:R:Y152	24.7852	10.09	No	Yes	4	7	7
27	R:R:G395	R:R:S155	20.531	3.71	No	No	0	9	9
28	R:R:L396	R:R:S155	22.3067	3	Yes	No	0	7	9
29	R:R:I188	R:R:L159	10.566	5.71	Yes	No	0	7	9
30	R:R:F184	R:R:L159	13.1667	4.87	No	No	0	8	9
31	R:R:F184	R:R:L166	14.4264	4.87	No	No	0	8	8
32	R:R:L166	R:R:N177	23.271	10.98	No	Yes	0	8	9
33	R:R:H180	R:R:N177	33.2801	3.83	Yes	Yes	1	9	9
34	R:R:H180	R:R:Y402	35.1136	25.04	Yes	Yes	1	9	8
35	R:R:F169	R:R:L172	11.7272	4.87	Yes	Yes	1	7	9
36	R:R:L172	R:R:N177	16.3651	4.12	Yes	Yes	1	9	9
37	R:R:S352	W:W:?1	18.5448	4.05	No	Yes	0	9	0
38	R:R:E247	R:R:Y402	20.0998	14.59	No	Yes	1	9	8
39	R:R:E247	R:R:I179	22.8568	5.47	No	No	0	9	8
40	R:R:I179	R:R:W243	22.979	4.7	No	Yes	0	8	9
41	R:R:W243	R:R:W274	11.279	18.74	Yes	Yes	8	9	9
42	R:R:F187	R:R:G395	15.5027	4.52	Yes	No	6	8	9
43	R:R:L232	R:R:S193	10.6746	4.5	No	No	0	5	6
44	R:R:M233	R:R:S193	42.1417	6.13	No	No	0	6	6
45	R:R:M233	R:R:V194	45.6286	3.04	No	No	0	6	7
46	R:R:S193	R:R:V229	28.1126	1.62	No	No	0	6	7
47	R:R:V229	R:R:Y220	21.0641	3.79	No	Yes	0	7	3
48	R:R:R299	R:R:T298	10.3249	2.59	No	No	0	4	5
49	R:R:R299	R:R:W297	11.4386	5	No	Yes	0	4	8
50	R:R:N300	R:R:W297	21.0301	7.91	Yes	Yes	2	6	8
51	R:R:N300	R:R:W306	50.5959	16.95	Yes	No	0	6	6
52	R:R:R310	R:R:W306	52.8978	14.99	No	No	0	6	6
53	R:R:E364	R:R:R310	53.6516	6.98	No	No	0	8	6
54	R:R:C317	R:R:E364	55.8721	3.04	No	No	0	7	8
55	R:R:C317	R:R:C361	56.5987	7.28	No	No	0	7	9
56	R:R:C361	R:R:F321	58.9685	4.19	No	Yes	0	9	6
57	R:R:N300	R:R:W284	20.8739	3.39	Yes	Yes	2	6	8
58	R:R:I309	R:R:W284	17.4278	10.57	No	Yes	2	7	8
59	R:R:F280	R:R:I309	16.4839	5.02	Yes	No	0	5	7
60	R:R:C361	R:R:N320	15.0986	4.72	No	No	0	9	9
61	R:R:L245	R:R:N320	13.3195	10.98	No	No	0	8	9
62	R:R:V246	R:R:Y269	12.5997	10.09	No	No	0	8	7
63	R:R:L251	R:R:T353	10.5286	4.42	Yes	Yes	0	9	9
64	R:R:L251	R:R:L349	10.1042	6.92	Yes	No	0	9	9
65	R:R:L349	R:R:Y402	10.678	3.52	No	Yes	0	9	8
66	R:R:L255	R:R:V327	11.9988	4.47	No	Yes	0	8	9
67	R:R:I330	R:R:L255	11.0108	4.28	No	No	0	9	8
68	R:R:E292	R:R:Y305	12.2568	12.35	Yes	Yes	0	6	4
69	R:R:F347	W:W:?1	11.9411	11.5	Yes	Yes	3	7	0
70	R:R:L401	R:R:T355	10.2502	4.42	Yes	No	0	8	8
71	R:R:V246	R:R:W243	13.1701	3.68	No	Yes	0	8	9
72	R:R:L251	R:R:V327	15.5706	2.98	Yes	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F347	R:R:L335	6.09	3	Yes	No	7	8	1	2
R:R:F347	R:R:M340	4.98	3	Yes	No	7	5	1	2
R:R:F347	R:R:K342	18.61	3	Yes	No	7	5	1	1
R:R:K342	W:W:?1	3.8	3	No	Yes	5	0	1	0
R:R:I345	R:R:R348	5.01	3	No	Yes	5	8	2	1
R:R:E408	R:R:I345	4.1	3	No	No	9	5	2	2
R:R:F347	R:R:K351	6.2	3	Yes	No	7	8	1	1
R:R:F347	W:W:?1	11.5	3	Yes	Yes	7	0	1	0
R:R:N407	R:R:R348	12.05	0	No	Yes	6	8	2	1
R:R:E408	R:R:R348	10.47	3	No	Yes	9	8	2	1
R:R:R348	W:W:?1	11.47	3	Yes	Yes	8	0	1	0
R:R:K351	W:W:?1	35.19	3	No	Yes	8	0	1	0
R:R:L401	R:R:S352	7.51	0	Yes	No	8	9	2	1
R:R:S352	R:R:Y402	6.36	0	No	Yes	9	8	1	2
R:R:S352	W:W:?1	4.05	0	No	Yes	9	0	1	0
R:R:L401	R:R:T355	4.42	0	Yes	No	8	8	2	1
R:R:T355	W:W:?1	3.98	0	No	Yes	8	0	1	0
R:R:V405	W:W:?1	8.04	0	No	Yes	6	0	1	0
R:R:E408	R:R:N406	13.15	3	No	No	9	9	2	1
R:R:N406	R:R:V409	10.35	0	No	No	9	9	1	2
R:R:N406	W:W:?1	3.7	0	No	Yes	9	0	1	0
R:R:Q410	R:R:V405	1.43	0	No	No	7	6	2	1
R:R:Q410	R:R:V409	1.43	0	No	No	7	9	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
77.78	Single	5VEX	NNC0640	5VEX-GLP-1-NNC0640
70.00	Single	6KJV	PubChem 68178630	6KJV-GLP-1-PubChem 68178630
70.00	Single	6KK1	PubChem 68178630	6KK1-GLP-1-PubChem 68178630
63.64	Single	5XEZ	NNC0640	5XEZ-Glucagon-NNC0640
58.33	Single	5XF1	NNC0640	5XF1-Glucagon-NNC0640
54.55	Single	5VEW	PF-06372222	5VEW-GLP-1-PF-06372222
53.33	Single	6LN2	PubChem 68178630	6LN2-GLP-1-PubChem 68178630
41.67	Single	8PJK	t7m	8PJK-5-HT_1A-ST171-t7m-Gi1/β1/γ1
40.00	Single	8PKM	t7m	8PKM-5-HT_1A-Befiradol-t7m-Gi1/β1/γ1
29.41	Single	8TB7	PubChem 168510218	8TB7-GPR61-PubChem 168510218
27.27	Single	7EB2	rac-BHFF	7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
23.08	Single	7CA3	rac-BHFF	7CA3-GABA_B1, GABA_B2-rac-BHFF
21.43	Single	7C7Q	PubChem 7023848	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
20.00	Single	4PXF	Octyl-Beta-D-Glucopyranoside	4PXF-Rhodopsin-Octyl-β-D-Glucopyranoside-Arrestin1 Finger Loop
20.00	Single	5X7D	PubChem 129318963	5X7D-β₂-S-Carazolol-PubChem 129318963
20.00	Single	7DUQ	PubChem 156022738	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
18.75	Single	8JPF	PubChem 118610427	8JPF-NTS₁-Neurotensin-PubChem 118610427
15.38	Single	8Y69	Cholesterol	8Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
15.00	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
14.29	Single	5T1A	PubChem 68764898; PubChem 12093170	5T1A-CCR2-PubChem 68764898; PubChem 12093170
14.29	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
14.29	Single	8Y69	Cholesterol	8Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
13.04	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
12.50	Single	7DUR	PubChem 156022738	7DUR-GLP-1-PubChem 156022738-Gs/β1/γ2
12.50	Single	8XQS	Flufenamic acid	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
11.76	Single	8JPC	PubChem 118610427; GDP; Mg	8JPC-NTS₁-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
11.11	Single	7E14	PubChem 156022738	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
11.11	Single	7EVM	PubChem 156022738	7EVM-GLP-1-PubChem 156022738-Gs/β1/γ2
11.11	Single	8GW8	KHF	8GW8-PTH1-KHF-Gs/β1/γ2
10.53	Single	8JPB	PubChem 118610427; GDP; Mg	8JPB-NTS₁-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
10.00	Single	5LWE	Vercirnon	5LWE-CCR9-Vercirnon
10.00	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
10.00	Single	8JR9	PCO371	8JR9-PTH1-PCO371-chim(NtGi1-Gs)/β1/γ2
9.09	Single	6UO8	GS39783	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
9.09	Single	8ZPM	Cholesterol	8ZPM-CXCR4-AMD070-Cholesterol
8.70	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
6.25	Single	8XQR	Flufenamic acid	8XQR-TAS2R14-Flufenamic acid-Gt3/β1/γ1
5.88	Single	8RQL	Flufenamic acid	8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
5.88	Single	8XQO	Aristolochic acid A	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
5.56	Single	8XQL	Aristolochic acid A	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.26	Single	6LFL	PubChem 153466996	6LFL-CXCR2-PubChem 153466996
4.17	Single	8FN0	PubChem 118610427	8FN0-NTS₁-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
3.45	Single	3VG9	Antibody	3VG9-A_2A-ZM-241385-Antibody
3.12	Single	3VGA	Antibody	3VGA-A_2A-ZM-241385-Antibody

PDB Summary
PDB	6KK7
Class	B1
SubFamily	Peptide
Type	Glucagon
SubType	GLP-1
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	PubChem 68178630
Protein Partners	-
PDB Resolution	3.1
Date	2019-11-13
D.O.I.	10.1107/S2052252519013496

Net Summary
I_min	2.98
Number of Linked Nodes	247
Number of Links	286
Number of Hubs	41
Number of Links mediated by Hubs	153
Number of Communities	10
Number of Nodes involved in Communities	56
Number of Links involved in Communities	73

Path Summary
Number Of Nodes in MetaPath	73
Number Of Links MetaPath	72
Number of Shortest Paths	56241
Length Of Smallest Path	3
Average Path Length	15.1396
Length of Longest Path	34
Minimum Path Strength	1.235
Average Path Strength	6.33994
Maximum Path Strength	23.33
Minimum Path Correlation	0.7
Average Path Correlation	0.928395
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	45.4021
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.298
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• glucagon receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • amide binding • binding • peptide hormone binding • hormone binding • glucagon-like peptide 1 receptor activity • hydrolase activity, acting on glycosyl bonds • peptidoglycan muralytic activity • hydrolase activity, hydrolyzing O-glycosyl compounds • lysozyme activity • hydrolase activity • catalytic activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • heart process • multicellular organismal process • system process • regulation of biological process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • heart process • multicellular organismal process • system process • regulation of biological process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • regulation of blood pressure • positive regulation of blood pressure • cellular response to stimulus • regulation of cellular process • response to stimulus • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to stress • response to psychosocial stress • cell surface receptor signaling pathway • behavior • learning or memory • nervous system process • cognition • transport • secretion • regulation of hormone levels • cell-cell signaling • export from cell • hormone secretion • establishment of localization • localization • secretion by cell • signal release • hormone transport • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • protein localization • establishment of protein localization • cellular localization • nitrogen compound transport • protein targeting • protein transmembrane transport • cellular macromolecule localization • establishment of localization in cell • post-translational protein targeting to membrane, translocation • establishment of protein localization to endoplasmic reticulum • protein localization to endoplasmic reticulum • establishment of protein localization to membrane • intracellular protein transmembrane transport • intracellular transport • post-translational protein targeting to endoplasmic reticulum membrane • localization within membrane • protein localization to membrane • protein targeting to membrane • transmembrane transport • establishment of protein localization to organelle • protein transport • macromolecule localization • protein localization to organelle • intracellular protein transport • protein targeting to ER • negative regulation of blood pressure • biological process involved in interspecies interaction between organisms • response to other organism • defense response • response to external stimulus • response to biotic stimulus • defense response to bacterium • defense response to other organism • response to bacterium • response to external biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process • carbohydrate derivative metabolic process • aminoglycan catabolic process • macromolecule catabolic process • glycosaminoglycan catabolic process • aminoglycan metabolic process • peptidoglycan metabolic process • metabolic process • macromolecule metabolic process • symbiont-mediated cytolysis of host cell • viral life cycle • disruption of cell in another organism • cytolysis • biological process involved in interaction with host • biological process involved in symbiotic interaction • viral release from host cell by cytolysis • exit from host cell • viral process • cytolysis in another organism • viral release from host cell • disruption of anatomical structure in another organism • symbiont-mediated killing of host cell • killing of cells of another organism • cell killing • cell wall organization or biogenesis • cell wall macromolecule catabolic process • cell wall macromolecule metabolic process • cellular anatomical structure • membrane • cell periphery • plasma membrane • host cellular component • host intracellular part • host cell cytoplasm • host cell part • host intracellular region
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	97Y
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	97Y
Name	N-{4-[(R)-(3,3-dimethylcyclobutyl)({6-[4-(trifluoromethyl)-1H-imidazol-1-yl]pyridin-3-yl}amino)methyl]benzene-1-carbonyl}-beta-alanine
Synonyms
Identifier
Formula	C26 H28 F3 N5 O3
Molecular Weight	515.527
SMILES
PubChem	68178630
Formal Charge	0
Total Atoms	65
Total Chiral Atoms	1
Total Bonds	68
Total Aromatic Bonds	17


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43220
Sequence	>6KK7_Chain_R S P E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F R H L H C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W S Y Q D S L A C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E D E G C W T R N S N M N Y W L I I R L P I L F A C I V N F L I F V R V I C I V V S K L K A N L M C K T D I A F R L A K S T L T L I P L L C T H E V I F A F V M R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E V Q L E F R K S W E R W R L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9IVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839	chim(NtGi1-Gs)/β2/γ2	3.22	2024-11-13	10.1016/j.apsb.2024.09.002
	9IVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839		3.22	2024-11-13	10.1016/j.apsb.2024.09.002
	8YW3	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8WG7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.54	2024-03-06	10.1038/s41421-024-00649-0
	8WG7 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.54	2024-03-06	10.1038/s41421-024-00649-0
	8JIS	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-	chim(NtGi1-Gs)/β1/γ2	2.46	2023-11-08	10.1073/pnas.2303696120
	8JIS (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-		2.46	2023-11-08	10.1073/pnas.2303696120
	8JIR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-	chim(NtGi1-Gs)/β1/γ2	2.57	2023-09-06	10.1073/pnas.2303696120
	8JIR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-		2.57	2023-09-06	10.1073/pnas.2303696120
	8JIP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-	chim(NtGi1-Gs)/β1/γ2	2.85	2023-09-06	10.1073/pnas.2303696120
	8JIP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-		2.85	2023-09-06	10.1073/pnas.2303696120
	9IVG	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	chim(NtGi1-Gs)/β1/γ2	3	2024-11-27	10.1016/j.apsb.2024.09.002
	9IVG (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-		3	2024-11-27	10.1016/j.apsb.2024.09.002
	9J1P	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-	chim(NtGi1-Gs)/β1/γ2	2.99	2025-02-26	10.1021/jacs.4c12808
	9J1P (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-		2.99	2025-02-26	10.1021/jacs.4c12808
	7X8S	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-	Gs/β1/γ2	3.09	2022-06-29	10.1073/pnas.2200155119
	7X8S (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-		3.09	2022-06-29	10.1073/pnas.2200155119
	7X8R	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-	Gs/β1/γ2	2.61	2022-06-29	10.1073/pnas.2200155119
	7X8R (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-		2.61	2022-06-29	10.1073/pnas.2200155119
	7S15	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 134611223	-	-	3.8	2022-06-08	10.1021/acs.jmedchem.1c01856
	7RGP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2022-04-13	10.1073/pnas.2116506119
	7RGP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		2.9	2022-04-13	10.1073/pnas.2116506119
	7RG9	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-04-13	10.1073/pnas.2116506119
	7RG9 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.2	2022-04-13	10.1073/pnas.2116506119
	7VBH	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3	2022-04-06	10.1038/s41467-022-28683-0
	7VBH (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-		3	2022-04-06	10.1038/s41467-022-28683-0
	7VBI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-	Gs/β1/γ2	3	2022-03-02	10.1038/s41467-022-28683-0
	7VBI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-		3	2022-03-02	10.1038/s41467-022-28683-0
	7FIM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	10.1038/s41467-022-28683-0
	7FIM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	10.1038/s41467-022-28683-0
	7LLY	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-	Gs/β1/γ2	3.3	2022-01-12	10.1038/s41467-021-27760-0
	7LLY (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-		3.3	2022-01-12	10.1038/s41467-021-27760-0
	7LLL	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	3.7	2022-01-12	10.1038/s41467-021-27760-0
	7LLL (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		3.7	2022-01-12	10.1038/s41467-021-27760-0
	7S3I	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.51	2022-01-05	10.1038/s41589-021-00945-w
	7S3I (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.51	2022-01-05	10.1038/s41589-021-00945-w
	7S1M	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-	Gs/β1/γ2	2.41	2022-01-05	10.1038/s41589-021-00945-w
	7S1M (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-		2.41	2022-01-05	10.1038/s41589-021-00945-w
	7RTB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-	Gs/β1/γ2	2.14	2021-10-06	10.1016/j.bbrc.2021.09.016
	7RTB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-		2.14	2021-10-06	10.1016/j.bbrc.2021.09.016
	7EVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	2.5	2021-08-11	10.1038/s41467-021-24058-z
	7EVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		2.5	2021-08-11	10.1038/s41467-021-24058-z
	7DUR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	3.3	2021-08-11	10.1038/s41467-021-24058-z
	7DUR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		3.3	2021-08-11	10.1038/s41467-021-24058-z
	7KI1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-	Gs/β1/γ2	2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI1 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-		2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI0	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-	Gs/β1/γ2	2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI0 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-		2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7DUQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738	Gs/β1/γ2	2.5	2021-07-14	10.1038/s41467-021-24058-z
	7DUQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738		2.5	2021-07-14	10.1038/s41467-021-24058-z
	7E14	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738	Gs/β1/γ2	2.9	2021-07-07	10.1038/s41467-021-24058-z
	7E14 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738		2.9	2021-07-07	10.1038/s41467-021-24058-z
	7LCK	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	3.24	2021-01-20	10.1016/j.str.2021.04.008
	7LCJ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	2.82	2021-01-20	10.1016/j.str.2021.04.008
	7LCI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.9	2021-01-20	10.1016/j.str.2021.04.008
	7LCI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.9	2021-01-20	10.1016/j.str.2021.04.008
	6XOX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-	chim(NtGi1-Gs)/β1/γ2	3.1	2020-11-18	10.1073/pnas.2014879117
	6XOX (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-		3.1	2020-11-18	10.1073/pnas.2014879117
	6X1A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.5	2020-09-09	10.1016/j.molcel.2020.09.020
	6X1A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.5	2020-09-09	10.1016/j.molcel.2020.09.020
	6X19	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-	Gs/β1/γ2	2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X19 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-		2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X18	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X18 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	7C2E	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-	Gs/β1/γ2	4.2	2020-08-26	10.1038/s41422-020-0384-8
	7C2E (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-		4.2	2020-08-26	10.1038/s41422-020-0384-8
	6VCB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440	Gs/β1/γ2	3.3	2020-07-22	10.1038/s41589-020-0589-7
	6VCB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440		3.3	2020-07-22	10.1038/s41589-020-0589-7
	6LN2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	3.2	2020-03-18	10.1038/s41467-020-14934-5
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	10.1038/s41586-019-1902-z
	6KK7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	3.1	2019-11-13	10.1107/S2052252519013496
	6KK1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	2.8	2019-11-13	10.1107/S2052252519013496
	6KJV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	2.8	2019-11-13	10.1107/S2052252519013496
	6B3J	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-	Gs/β1/γ2	3.3	2018-02-21	10.1038/nature25773
	6B3J (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-		3.3	2018-02-21	10.1038/nature25773
	5NX2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	-	3.7	2017-06-14	10.1038/nature22800
	5VEW	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.7	2017-05-24	10.1038/nature22378
	5VAI	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-	Gs/β1/γ2	4.1	2017-05-24	10.1038/nature22394
	5VAI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-		4.1	2017-05-24	10.1038/nature22394
	5VEX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	NNC0640	-	3	2017-05-17	10.1038/nature22378

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