psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	H:H:?7	H:H:?8	36.53	Yes	No	2	0	0
2	H:H:?7	R:R:Y39	7.34	Yes	Yes	2	0	6
3	H:H:?7	R:R:Q42	15.47	Yes	No	2	0	5
4	H:H:?7	R:R:N46	31.93	Yes	No	0	0	5
5	H:H:?7	R:R:C67	2.84	Yes	Yes	2	0	9
6	H:H:?8	R:R:Q42	5.95	No	No	2	0	5
7	H:H:?10	H:H:?9	43.17	No	No	0	0	0
8	H:H:?9	R:R:N78	25.79	No	No	7	0	4
9	H:H:?9	R:R:F97	6.54	No	Yes	7	0	5
10	H:H:?12	R:R:P53	2.94	No	Yes	0	0	3
11	H:H:?12	R:R:N59	25.79	No	No	0	0	4
12	H:H:?13	R:R:N74	22.1	No	No	0	0	7
13	R:R:F31	R:R:Q27	8.2	No	No	0	4	5
14	R:R:V28	R:R:Y202	7.57	No	Yes	0	3	1
15	R:R:L32	R:R:M29	4.24	No	No	2	4	5
16	R:R:M29	R:R:Y202	2.39	No	Yes	2	5	1
17	R:R:L32	R:R:P86	3.28	No	Yes	2	4	3
18	R:R:L32	R:R:Y202	3.52	No	Yes	2	4	1
19	R:R:E34	R:R:F33	3.5	No	No	0	2	4
20	R:R:F33	R:R:W36	4.01	No	Yes	0	4	6
21	R:R:F62	R:R:W36	5.01	Yes	Yes	0	7	6
22	R:R:K64	R:R:W36	2.32	No	Yes	0	4	6
23	R:R:W36	R:R:Y84	9.65	Yes	Yes	0	6	5
24	R:R:D41	R:R:K37	11.06	No	No	0	4	3
25	R:R:L38	R:R:W83	2.28	No	Yes	0	3	2
26	R:R:F62	R:R:Y39	4.13	Yes	Yes	0	7	6
27	R:R:S66	R:R:Y39	2.54	Yes	Yes	2	5	6
28	R:R:C67	R:R:Y39	4.03	Yes	Yes	2	9	6
29	R:R:P82	R:R:Y39	5.56	Yes	Yes	2	8	6
30	R:R:W83	R:R:Y39	16.4	Yes	Yes	0	2	6
31	R:R:Y39	R:R:Y84	8.94	Yes	Yes	2	6	5
32	R:R:F62	R:R:G40	6.02	Yes	No	0	7	4
33	R:R:Q42	R:R:W83	6.57	No	Yes	0	5	2
34	R:R:C43	R:R:L47	3.17	No	No	2	9	5
35	R:R:C43	R:R:F62	8.38	No	Yes	0	9	7
36	R:R:C43	R:R:C67	7.28	No	Yes	2	9	9
37	R:R:F62	R:R:H44	3.39	Yes	No	0	7	2
38	R:R:L47	R:R:R60	8.5	No	Yes	2	5	4
39	R:R:C67	R:R:L47	4.76	Yes	No	2	9	5
40	R:R:L50	R:R:P51	4.93	No	No	0	3	2
41	R:R:L50	R:R:R60	2.43	No	Yes	0	3	4
42	R:R:P53	R:R:V57	3.53	Yes	No	2	3	3
43	R:R:P53	R:R:R60	2.88	Yes	Yes	2	3	4
44	R:R:D70	R:R:P53	8.05	No	Yes	2	4	3
45	R:R:E55	R:R:V57	5.7	No	No	0	4	3
46	R:R:E55	R:R:P72	4.72	No	No	0	4	1
47	R:R:D70	R:R:V57	5.84	No	No	2	4	3
48	R:R:C100	R:R:C58	7.28	No	No	2	9	9
49	R:R:C58	R:R:W106	15.67	No	Yes	2	9	9
50	R:R:D70	R:R:R60	17.87	No	Yes	2	4	4
51	R:R:T61	R:R:W106	3.64	No	Yes	0	6	9
52	R:R:D63	R:R:Y65	2.3	Yes	Yes	2	9	6
53	R:R:D63	R:R:W68	10.05	Yes	Yes	2	9	9
54	R:R:D63	R:R:K98	9.68	Yes	Yes	2	9	8
55	R:R:D63	R:R:P114	6.44	Yes	No	0	9	5
56	R:R:D63	R:R:R116	10.72	Yes	Yes	2	9	6
57	R:R:S66	R:R:Y65	6.36	Yes	Yes	2	5	6
58	R:R:P82	R:R:Y65	9.74	Yes	Yes	2	8	6
59	R:R:Y65	R:R:Y84	3.97	Yes	Yes	2	6	5
60	R:R:L85	R:R:Y65	2.34	Yes	Yes	2	6	6
61	R:R:V96	R:R:Y65	3.79	Yes	Yes	2	7	6
62	R:R:R116	R:R:Y65	12.35	Yes	Yes	2	6	6
63	R:R:A118	R:R:Y65	5.34	No	Yes	2	5	6
64	R:R:C121	R:R:Y65	4.03	No	Yes	2	9	6
65	R:R:S66	R:R:W68	3.71	Yes	Yes	2	5	9
66	R:R:I79	R:R:S66	3.1	No	Yes	2	4	5
67	R:R:P82	R:R:S66	5.34	Yes	Yes	2	8	5
68	R:R:S66	R:R:V96	3.23	Yes	Yes	2	5	7
69	R:R:P69	R:R:W68	2.7	No	Yes	0	6	9
70	R:R:A77	R:R:W68	2.59	No	Yes	2	7	9
71	R:R:I79	R:R:W68	8.22	No	Yes	2	4	9
72	R:R:V96	R:R:W68	4.9	Yes	Yes	2	7	9
73	R:R:K98	R:R:W68	19.73	Yes	Yes	2	8	9
74	R:R:W106	R:R:W68	2.81	Yes	Yes	2	9	9
75	R:R:P72	R:R:T71	5.25	No	Yes	2	1	7
76	R:R:T71	R:R:T75	3.14	Yes	No	2	7	5
77	R:R:A77	R:R:T71	5.03	No	Yes	2	7	7
78	R:R:C100	R:R:T71	5.07	No	Yes	2	9	7
79	R:R:T71	R:R:W106	7.28	Yes	Yes	2	7	9
80	R:R:P72	R:R:T75	6.99	No	No	2	1	5
81	R:R:N74	R:R:P102	4.89	No	No	0	7	1
82	R:R:F97	R:R:T76	3.89	Yes	No	0	5	5
83	R:R:R99	R:R:T76	10.35	No	No	0	3	5
84	R:R:A77	R:R:W106	2.59	No	Yes	2	7	9
85	R:R:F97	R:R:N78	4.83	Yes	No	7	5	4
86	R:R:F95	R:R:S80	5.28	No	No	0	1	3
87	R:R:C81	R:R:V91	5.12	No	Yes	0	9	6
88	R:R:C121	R:R:C81	7.28	No	No	0	9	9
89	R:R:P82	R:R:Y84	9.74	Yes	Yes	2	8	5
90	R:R:L85	R:R:P82	4.93	Yes	Yes	2	6	8
91	R:R:H88	R:R:W83	5.29	No	Yes	0	4	2
92	R:R:L85	R:R:Y84	4.69	Yes	Yes	2	6	5
93	R:R:L85	R:R:P86	3.28	Yes	Yes	2	6	3
94	R:R:L85	R:R:W87	5.69	Yes	Yes	2	6	3
95	R:R:P86	R:R:W87	10.81	Yes	Yes	2	3	3
96	R:R:P86	R:R:Y202	11.13	Yes	Yes	2	3	1
97	R:R:V91	R:R:W87	4.9	Yes	Yes	0	6	3
98	R:R:M123	R:R:W87	12.8	Yes	Yes	2	3	3
99	R:R:W215	R:R:W87	13.12	No	Yes	2	2	3
100	R:R:H88	R:R:H89	5.97	No	No	8	4	5
101	R:R:H88	R:R:Q92	7.42	No	No	8	4	1
102	R:R:H89	R:R:Q92	3.71	No	No	8	5	1
103	R:R:D218	R:R:K90	5.53	No	No	0	4	4
104	R:R:R94	R:R:V91	2.62	No	Yes	0	5	6
105	R:R:H93	R:R:R94	9.03	No	No	0	4	5
106	R:R:Q120	R:R:R94	22.2	No	No	0	5	5
107	R:R:F95	R:R:F97	2.14	No	Yes	0	1	5
108	R:R:R116	R:R:V96	3.92	Yes	Yes	2	6	7
109	R:R:A118	R:R:V96	3.39	No	Yes	2	5	7
110	R:R:D117	R:R:F97	2.39	No	Yes	0	7	5
111	R:R:F97	R:R:Q120	3.51	Yes	No	0	5	5
112	R:R:K98	R:R:W106	22.05	Yes	Yes	2	8	9
113	R:R:K98	R:R:R116	2.48	Yes	Yes	2	8	6
114	R:R:R99	R:R:V107	3.92	No	No	0	3	5
115	R:R:C100	R:R:W106	2.61	No	Yes	2	9	9
116	R:R:G101	R:R:P102	4.06	No	No	0	5	1
117	R:R:D103	R:R:P102	4.83	No	No	0	5	1
118	R:R:G112	R:R:R108	6	No	No	0	6	1
119	R:R:G109	R:R:P110	4.06	No	No	9	4	3
120	R:R:G109	R:R:Q113	3.29	No	Yes	9	4	4
121	R:R:G109	R:R:W115	2.81	No	No	0	4	4
122	R:R:P110	R:R:Q113	4.74	No	Yes	9	3	4
123	R:R:Q113	R:R:R111	4.67	Yes	No	0	4	4
124	R:R:P114	R:R:Q113	3.16	No	Yes	0	5	4
125	R:R:D117	R:R:S119	8.83	No	No	0	7	5
126	R:R:A118	R:R:C121	3.61	No	No	2	5	9
127	R:R:M123	R:R:S213	3.07	Yes	No	0	3	3
128	R:R:M123	R:R:W215	2.33	Yes	No	2	3	2
129	R:R:D124	R:R:W215	2.23	No	No	0	2	2
130	R:R:G125	R:R:T214	3.64	No	Yes	0	2	1
131	R:R:E126	R:R:T214	2.82	No	Yes	0	3	1
132	R:R:E127	R:R:Q204	5.1	No	No	5	1	4
133	R:R:E127	R:R:I206	2.73	No	Yes	5	1	4
134	R:R:E127	R:R:S211	8.62	No	No	5	1	4
135	R:R:I128	R:R:T214	3.04	No	Yes	0	2	1
136	R:R:E129	R:R:I206	4.1	No	Yes	0	1	4
137	R:R:D209	R:R:E129	9.09	No	No	0	4	1
138	R:R:Q131	R:R:V134	4.3	No	No	0	3	2
139	R:R:D209	R:R:Q131	3.92	No	No	0	4	3
140	R:R:K132	R:R:K136	7.18	No	No	0	2	2
141	R:R:V134	R:R:Y138	2.52	No	No	0	2	5
142	R:R:A135	R:R:L210	3.15	No	No	0	3	4
143	R:R:F141	R:R:M137	6.22	No	No	10	6	4
144	R:R:F383	R:R:M137	2.49	No	No	10	5	4
145	R:R:F383	R:R:Y138	2.06	No	No	0	5	5
146	R:R:F141	R:R:M144	6.22	No	No	0	6	6
147	R:R:F141	R:R:F383	25.72	No	No	10	6	5
148	R:R:D195	R:R:Q142	5.22	No	No	0	7	5
149	R:R:Q142	R:R:R199	4.67	No	No	0	5	4
150	R:R:F387	R:R:M144	17.42	No	No	0	5	6
151	R:R:Y145	R:R:Y149	5.96	No	Yes	3	7	8
152	R:R:V191	R:R:Y145	5.05	No	No	3	7	7
153	R:R:L386	R:R:Y145	8.21	No	No	0	7	7
154	R:R:G148	R:R:S390	3.71	No	Yes	3	7	9
155	R:R:F391	R:R:G148	7.53	No	No	3	7	7
156	R:R:K187	R:R:Y149	10.75	Yes	Yes	0	8	8
157	R:R:A188	R:R:Y149	5.34	No	Yes	0	8	8
158	R:R:V191	R:R:Y149	5.05	No	Yes	3	7	8
159	R:R:S390	R:R:Y149	5.09	Yes	Yes	3	9	8
160	R:R:L192	R:R:S150	4.5	No	No	0	7	7
161	R:R:G393	R:R:S152	3.71	No	No	0	9	9
162	R:R:L394	R:R:S152	3	Yes	No	0	5	9
163	R:R:A155	R:R:L394	4.73	No	Yes	0	6	5
164	R:R:F181	R:R:L156	4.87	Yes	Yes	0	8	8
165	R:R:F184	R:R:L156	2.44	Yes	Yes	0	8	8
166	R:R:L156	R:R:V185	5.96	Yes	No	0	8	8
167	R:R:A397	R:R:L156	3.15	No	Yes	0	8	8
168	R:R:I162	R:R:L158	4.28	No	No	1	8	5
169	R:R:F402	R:R:L158	6.09	Yes	No	1	9	5
170	R:R:A159	R:R:F181	2.77	No	Yes	1	9	8
171	R:R:A159	R:R:C401	3.61	No	Yes	1	9	9
172	R:R:A159	R:R:F402	2.77	No	Yes	1	9	9
173	R:R:F181	R:R:L160	2.44	Yes	No	0	8	6
174	R:R:C401	R:R:I162	3.27	Yes	No	1	9	8
175	R:R:F402	R:R:I162	3.77	Yes	No	1	9	8
176	R:R:L163	R:R:N174	5.49	No	No	0	8	9
177	R:R:C401	R:R:L163	3.17	Yes	No	0	9	8
178	R:R:G164	R:R:G165	2.11	No	No	0	3	3
179	R:R:E410	R:R:S167	2.87	No	No	0	8	8
180	R:R:K168	R:R:N174	8.39	No	No	0	8	9
181	R:R:E406	R:R:K168	9.45	No	No	0	9	8
182	R:R:H170	R:R:L169	10.29	No	No	0	7	9
183	R:R:C171	R:R:N174	9.45	No	No	0	7	9
184	R:R:R261	R:R:T172	7.76	No	No	0	5	7
185	R:R:R173	R:R:Y248	8.23	Yes	Yes	1	9	8
186	R:R:R173	R:R:Y343	5.14	Yes	Yes	1	9	7
187	R:R:L347	R:R:R173	4.86	Yes	Yes	1	9	9
188	R:R:N404	R:R:R173	6.03	No	Yes	0	9	9
189	R:R:I176	R:R:W241	2.35	Yes	Yes	1	9	9
190	R:R:I176	R:R:V244	4.61	Yes	Yes	1	9	8
191	R:R:E245	R:R:I176	8.2	Yes	Yes	1	9	9
192	R:R:I176	R:R:Y248	8.46	Yes	Yes	1	9	8
193	R:R:I176	R:R:L268	5.71	Yes	Yes	1	9	5
194	R:R:F181	R:R:H177	2.26	Yes	Yes	1	8	9
195	R:R:E245	R:R:H177	12.31	Yes	Yes	1	9	9
196	R:R:H177	R:R:L347	2.57	Yes	Yes	1	9	9
197	R:R:H177	R:R:Y400	20.69	Yes	Yes	1	9	8
198	R:R:N179	R:R:W241	12.43	No	Yes	1	8	9
199	R:R:N179	R:R:W272	9.04	No	Yes	1	8	9
200	R:R:F181	R:R:L180	4.87	Yes	Yes	1	8	9
201	R:R:F184	R:R:L180	3.65	Yes	Yes	1	8	9
202	R:R:L180	R:R:W241	2.28	Yes	Yes	1	9	9
203	R:R:L180	R:R:L242	2.77	Yes	No	0	9	9
204	R:R:E245	R:R:L180	3.98	Yes	Yes	1	9	9
205	R:R:L180	R:R:V396	2.98	Yes	Yes	1	9	9
206	R:R:L180	R:R:Y400	2.34	Yes	Yes	1	9	8
207	R:R:F181	R:R:V396	3.93	Yes	Yes	1	8	9
208	R:R:F181	R:R:Y400	3.09	Yes	Yes	1	8	8
209	R:R:C401	R:R:F181	2.79	Yes	Yes	1	9	8
210	R:R:A182	R:R:W272	2.59	No	Yes	0	4	9
211	R:R:F184	R:R:S183	3.96	Yes	No	1	8	9
212	R:R:N238	R:R:S183	7.45	Yes	No	1	9	9
213	R:R:S183	R:R:W272	2.47	No	Yes	1	9	9
214	R:R:F184	R:R:N238	22.96	Yes	Yes	1	8	9
215	R:R:F184	R:R:Q392	2.34	Yes	Yes	1	8	9
216	R:R:F184	R:R:G393	4.52	Yes	No	0	8	9
217	R:R:F184	R:R:V396	2.62	Yes	Yes	1	8	9
218	R:R:F230	R:R:L186	2.44	No	No	0	4	7
219	R:R:I235	R:R:K187	4.36	No	Yes	0	5	8
220	R:R:K187	R:R:N238	5.6	Yes	Yes	0	8	9
221	R:R:K187	R:R:Q392	2.71	Yes	Yes	0	8	9
222	R:R:F230	R:R:S190	2.64	No	No	0	4	5
223	R:R:M231	R:R:S190	4.6	No	No	0	6	5
224	R:R:L197	R:R:V193	2.98	No	No	0	4	5
225	R:R:A227	R:R:V193	3.39	No	No	0	6	5
226	R:R:A227	R:R:I194	3.25	No	No	0	6	6
227	R:R:G196	R:R:R199	3	No	No	0	3	4
228	R:R:C224	R:R:L197	3.17	No	No	0	9	4
229	R:R:L198	R:R:R201	10.93	No	No	0	6	4
230	R:R:C294	R:R:L198	3.17	No	No	0	9	6
231	R:R:R201	R:R:V212	5.23	No	No	0	4	3
232	R:R:L216	R:R:R201	3.64	Yes	No	0	2	4
233	R:R:S213	R:R:Y202	5.09	No	Yes	0	3	1
234	R:R:S203	R:R:V212	4.85	No	No	0	4	3
235	R:R:I206	R:R:Q204	8.23	Yes	No	5	4	4
236	R:R:K205	R:R:L210	4.23	No	No	0	4	4
237	R:R:I206	R:R:S211	6.19	Yes	No	5	4	4
238	R:R:Q293	R:R:T214	4.25	No	Yes	0	4	1
239	R:R:A220	R:R:L216	4.73	No	Yes	0	6	2
240	R:R:R225	R:R:V221	3.92	Yes	No	0	8	4
241	R:R:C224	R:R:C294	7.28	No	No	0	9	9
242	R:R:C287	R:R:R225	4.18	No	Yes	6	3	8
243	R:R:N291	R:R:R225	12.05	No	Yes	6	6	8
244	R:R:R225	R:R:W295	15.99	Yes	Yes	6	8	9
245	R:R:F230	R:R:V226	2.62	No	No	0	4	4
246	R:R:Q232	R:R:V229	8.6	Yes	No	0	7	6
247	R:R:V229	R:R:W295	2.45	No	Yes	0	6	9
248	R:R:I235	R:R:M231	2.92	No	No	0	5	6
249	R:R:Q232	R:R:V279	11.46	Yes	No	11	7	6
250	R:R:A283	R:R:Q232	4.55	No	Yes	0	5	7
251	R:R:L307	R:R:Q232	9.32	No	Yes	11	7	7
252	R:R:W272	R:R:Y233	4.82	Yes	No	0	9	9
253	R:R:P275	R:R:Y233	2.78	Yes	No	0	9	9
254	R:R:M276	R:R:Y233	8.38	No	No	0	3	9
255	R:R:P275	R:R:V236	7.07	Yes	No	0	9	6
256	R:R:V236	R:R:V279	3.21	No	No	0	6	6
257	R:R:A237	R:R:W272	2.59	No	Yes	0	7	9
258	R:R:N238	R:R:Y239	2.33	Yes	Yes	0	9	8
259	R:R:V311	R:R:Y239	7.57	No	Yes	0	8	8
260	R:R:I315	R:R:Y239	4.84	Yes	Yes	0	7	8
261	R:R:L358	R:R:Y239	10.55	No	Yes	0	9	8
262	R:R:E362	R:R:Y239	6.73	No	Yes	0	8	8
263	R:R:C240	R:R:P275	7.53	No	Yes	0	6	9
264	R:R:V244	R:R:W241	7.36	Yes	Yes	1	8	9
265	R:R:L268	R:R:W241	5.69	Yes	Yes	1	5	9
266	R:R:G271	R:R:W241	8.44	No	Yes	0	9	9
267	R:R:W241	R:R:W272	21.56	Yes	Yes	1	9	9
268	R:R:L242	R:R:L354	5.54	No	Yes	0	9	9
269	R:R:I355	R:R:L242	4.28	No	No	0	8	9
270	R:R:I317	R:R:L243	2.85	No	No	0	6	8
271	R:R:L243	R:R:N318	10.98	No	No	0	8	9
272	R:R:F264	R:R:V244	6.55	Yes	Yes	1	6	8
273	R:R:L268	R:R:V244	5.96	Yes	Yes	1	5	8
274	R:R:E245	R:R:T351	2.82	Yes	Yes	1	9	9
275	R:R:E245	R:R:Y400	17.96	Yes	Yes	1	9	8
276	R:R:I321	R:R:L247	2.85	No	No	0	8	7
277	R:R:L252	R:R:Y248	7.03	Yes	Yes	1	8	8
278	R:R:E260	R:R:Y248	7.86	No	Yes	1	6	8
279	R:R:F264	R:R:Y248	7.22	Yes	Yes	1	6	8
280	R:R:L347	R:R:Y248	2.34	Yes	Yes	1	9	8
281	R:R:L249	R:R:L347	4.15	No	Yes	0	9	9
282	R:R:L249	R:R:T351	5.9	No	Yes	0	9	9
283	R:R:H250	R:R:R324	18.05	No	No	12	7	8
284	R:R:H250	R:R:I325	2.65	No	No	0	7	9
285	R:R:H250	R:R:L328	2.57	No	No	12	7	8
286	R:R:L252	R:R:N251	2.75	Yes	No	1	8	7
287	R:R:F263	R:R:N251	7.25	Yes	No	1	5	7
288	R:R:E260	R:R:L252	11.93	No	Yes	1	6	8
289	R:R:F263	R:R:L252	2.44	Yes	Yes	1	5	8
290	R:R:F264	R:R:L252	3.65	Yes	Yes	1	6	8
291	R:R:K332	R:R:L253	5.64	No	No	0	9	8
292	R:R:G254	R:R:L328	5.13	No	No	0	6	8
293	R:R:F263	R:R:F264	5.36	Yes	Yes	1	5	6
294	R:R:F263	R:R:Y267	7.22	Yes	No	0	5	7
295	R:R:F264	R:R:L268	13.4	Yes	Yes	1	6	5
296	R:R:L268	R:R:S265	3	Yes	No	0	5	3
297	R:R:L266	R:R:Y267	5.86	No	No	0	3	7
298	R:R:A274	R:R:I270	3.25	No	No	0	4	7
299	R:R:M276	R:R:V280	6.09	No	No	0	3	2
300	R:R:F278	R:R:W282	4.01	No	No	0	5	9
301	R:R:F278	R:R:P310	15.89	No	No	0	5	9
302	R:R:L307	R:R:V279	4.47	No	No	11	7	6
303	R:R:P281	R:R:V280	3.53	No	No	0	4	2
304	R:R:I306	R:R:W282	25.84	No	No	0	8	9
305	R:R:L288	R:R:V284	2.98	No	No	0	1	4
306	R:R:K286	R:R:M301	8.64	No	No	0	8	5
307	R:R:G302	R:R:K286	3.49	No	No	0	2	8
308	R:R:C287	R:R:L288	3.17	No	No	0	3	1
309	R:R:C287	R:R:W295	11.75	No	Yes	6	3	9
310	R:R:E290	R:R:S297	7.19	No	No	0	6	4
311	R:R:D299	R:R:E290	9.09	No	No	0	4	6
312	R:R:N291	R:R:W295	5.65	No	Yes	6	6	9
313	R:R:V292	R:R:W295	3.68	No	Yes	0	4	9
314	R:R:S297	R:R:V292	3.23	No	No	0	4	4
315	R:R:H372	R:R:N298	14.03	No	No	0	4	6
316	R:R:D370	R:R:N300	4.04	No	No	0	4	5
317	R:R:G302	R:R:I306	3.53	No	No	0	2	8
318	R:R:W304	R:R:W305	3.75	Yes	No	4	6	7
319	R:R:R308	R:R:W304	33.99	Yes	Yes	4	6	6
320	R:R:F309	R:R:W304	8.02	Yes	Yes	4	4	6
321	R:R:F312	R:R:W304	3.01	Yes	Yes	4	5	6
322	R:R:F367	R:R:W304	7.02	Yes	Yes	4	5	6
323	R:R:F309	R:R:W305	4.01	Yes	No	4	4	7
324	R:R:I306	R:R:L307	4.28	No	No	0	8	7
325	R:R:F309	R:R:R308	3.21	Yes	Yes	4	4	6
326	R:R:F312	R:R:R308	17.1	Yes	Yes	4	5	6
327	R:R:A366	R:R:R308	4.15	No	Yes	0	7	6
328	R:R:F367	R:R:R308	2.14	Yes	Yes	4	5	6
329	R:R:F309	R:R:P310	2.89	Yes	No	0	4	9
330	R:R:F312	R:R:V363	3.93	Yes	No	0	5	6
331	R:R:F312	R:R:F367	2.14	Yes	Yes	4	5	5
332	R:R:F319	R:R:I315	2.51	No	Yes	0	7	7
333	R:R:G359	R:R:I315	5.29	No	Yes	0	9	7
334	R:R:I315	R:R:V363	3.07	Yes	No	0	7	6
335	R:R:I317	R:R:I321	2.94	No	No	0	6	8
336	R:R:I355	R:R:N318	8.5	No	No	0	8	9
337	R:R:I321	R:R:I325	2.94	No	No	0	8	9
338	R:R:F322	R:R:L352	3.65	No	No	0	9	8
339	R:R:F322	R:R:P356	7.22	No	No	0	9	9
340	R:R:L328	R:R:R324	7.29	No	No	12	8	8
341	R:R:I325	R:R:L352	4.28	No	No	0	9	8
342	R:R:F345	R:R:L329	8.53	Yes	No	0	7	9
343	R:R:K332	R:R:Q337	8.14	No	No	0	9	7
344	R:R:K332	R:R:M338	5.76	No	No	0	9	5
345	R:R:L333	R:R:M338	4.24	Yes	No	1	7	5
346	R:R:F345	R:R:L333	3.65	Yes	Yes	1	7	7
347	R:R:Q337	R:R:R336	5.84	No	No	0	7	5
348	R:R:F345	R:R:M338	3.73	Yes	No	1	7	5
349	R:R:H339	R:R:H340	4.78	No	No	0	4	5
350	R:R:D342	R:R:Y343	4.6	No	Yes	1	7	7
351	R:R:D342	R:R:K344	6.91	No	No	1	7	6
352	R:R:K344	R:R:Y343	10.75	No	Yes	1	6	7
353	R:R:R346	R:R:Y343	4.12	No	Yes	0	8	7
354	R:R:F345	W:W:?3	7.46	Yes	Yes	1	7	0
355	R:R:K405	R:R:R346	16.09	No	No	0	6	8
356	R:R:R346	W:W:?3	3.31	No	Yes	0	8	0
357	R:R:L347	R:R:Y400	2.34	Yes	Yes	1	9	8
358	R:R:A348	R:R:L352	3.15	No	No	0	7	8
359	R:R:K349	W:W:?3	25.91	No	Yes	0	9	0
360	R:R:L399	R:R:S350	3	No	No	1	8	9
361	R:R:S350	R:R:Y400	7.63	No	Yes	1	9	8
362	R:R:S350	W:W:?3	11.24	No	Yes	1	9	0
363	R:R:T351	R:R:Y400	7.49	Yes	Yes	1	9	8
364	R:R:T353	W:W:?3	20.06	No	Yes	0	8	0
365	R:R:L354	R:R:L358	2.77	Yes	No	0	9	9
366	R:R:L354	R:R:V396	4.47	Yes	Yes	0	9	9
367	R:R:L354	R:R:Y400	4.69	Yes	Yes	0	9	8
368	R:R:I355	R:R:P356	3.39	No	No	0	8	9
369	R:R:L357	W:W:?3	2.83	No	Yes	0	9	0
370	R:R:L358	R:R:Q392	7.99	No	Yes	0	9	9
371	R:R:V360	R:R:V364	3.21	No	No	0	6	6
372	R:R:E362	R:R:H361	3.69	No	Yes	0	8	8
373	R:R:D385	R:R:H361	10.08	No	Yes	0	7	8
374	R:R:H361	R:R:L388	7.71	Yes	No	0	8	6
375	R:R:H361	R:R:S389	5.58	Yes	No	1	8	6
376	R:R:H361	R:R:Q392	2.47	Yes	Yes	1	8	9
377	R:R:F365	R:R:T369	3.89	No	No	0	7	7
378	R:R:D385	R:R:F365	16.72	No	No	0	7	7
379	R:R:F367	R:R:V368	3.93	Yes	No	0	5	5
380	R:R:K381	R:R:T369	7.51	No	No	0	7	7
381	R:R:E371	R:R:Q374	15.29	No	Yes	0	5	4
382	R:R:H372	R:R:R378	4.51	No	No	0	4	4
383	R:R:L377	R:R:Q374	11.98	No	Yes	0	3	4
384	R:R:Q374	R:R:R378	2.34	Yes	No	0	4	4
385	R:R:L382	R:R:R378	4.86	No	No	0	5	4
386	R:R:D385	R:R:K381	12.44	No	No	0	7	7
387	R:R:L382	R:R:L386	2.77	No	No	0	5	7
388	R:R:F384	R:R:L388	3.65	No	No	0	4	6
389	R:R:F387	R:R:S390	3.96	No	Yes	3	5	9
390	R:R:F387	R:R:F391	5.36	No	No	3	5	7
391	R:R:Q392	R:R:S389	2.89	Yes	No	1	9	6
392	R:R:F391	R:R:S390	3.96	No	Yes	3	7	9
393	R:R:L394	R:R:V398	2.98	Yes	No	0	5	6
394	R:R:A397	R:R:F402	2.77	No	Yes	0	8	9
395	R:R:L403	R:R:V398	2.98	No	No	0	5	6
396	R:R:L399	R:R:L403	4.15	No	No	1	8	5
397	R:R:L399	W:W:?3	9.42	No	Yes	1	8	0
398	R:R:L403	W:W:?3	2.83	No	Yes	1	5	0
399	R:R:N404	R:R:V407	5.91	No	No	0	9	9
400	R:R:N404	W:W:?3	9.34	No	Yes	0	9	0
401	R:R:Q408	R:R:R412	5.84	No	No	0	7	5
402	R:R:R413	R:R:S409	2.64	No	No	0	7	4
403	R:R:E410	R:R:R413	10.47	No	No	0	8	7
404	R:R:L411	R:R:R414	2.43	No	No	0	5	5
405	R:R:W415	R:R:W418	4.69	No	No	0	5	3
406	R:R:H416	R:R:R417	6.77	No	No	0	3	7
407	R:R:G273	R:R:P275	2.03	No	Yes	0	6	9
408	R:R:R414	R:R:W415	2	No	No	0	5	5
409	R:R:C58	R:R:G104	1.96	No	No	0	9	9
410	R:R:A25	R:R:G24	1.95	No	No	0	4	5
411	R:R:P51	R:R:P52	1.95	No	No	0	2	1
412	R:R:P52	R:R:P53	1.95	No	Yes	0	1	3
413	R:R:A73	R:R:G104	1.95	No	No	0	6	9
414	R:R:A222	R:R:G223	1.95	No	No	0	4	3
415	R:R:A237	R:R:G234	1.95	No	No	0	7	5
416	R:R:L395	W:W:?3	1.88	No	Yes	0	6	0
417	R:R:A25	R:R:P26	1.87	No	No	0	4	6
418	R:R:A274	R:R:P275	1.87	No	Yes	0	4	9
419	R:R:G101	R:R:V107	1.84	No	No	0	5	5
420	R:R:G246	R:R:T351	1.82	No	Yes	0	9	9
421	R:R:G375	R:R:T376	1.82	No	No	0	2	2
422	R:R:G125	R:R:M123	1.75	No	Yes	0	2	3
423	R:R:G104	R:R:L56	1.71	No	No	0	9	2
424	R:R:G154	R:R:L153	1.71	No	No	0	4	6
425	R:R:G164	R:R:L163	1.71	No	No	0	3	8
426	R:R:G223	R:R:L197	1.71	No	No	0	3	4
427	R:R:A220	R:R:S217	1.71	No	No	0	6	4
428	R:R:A135	R:R:V130	1.7	No	No	0	3	1
429	R:R:G112	R:R:Q113	1.64	No	Yes	0	6	4
430	R:R:G375	R:R:Q374	1.64	No	Yes	0	2	4
431	R:R:A228	R:R:I194	1.62	No	No	0	5	6
432	R:R:V130	R:R:V134	1.6	No	No	0	1	2
433	R:R:V363	R:R:V364	1.6	No	No	0	6	6
434	R:R:A188	R:R:L153	1.58	No	No	0	8	6
435	R:R:A178	R:R:L160	1.58	No	No	0	7	6
436	R:R:I128	R:R:V130	1.54	No	No	0	2	1
437	R:R:K90	R:R:V91	1.52	No	Yes	0	4	6
438	R:R:A335	R:R:Q337	1.52	No	No	0	7	7
439	R:R:K405	R:R:T341	1.5	No	No	0	6	6
440	R:R:L157	R:R:V185	1.49	No	No	0	3	8
441	R:R:L210	R:R:V212	1.49	No	No	0	4	3
442	R:R:L216	R:R:V221	1.49	Yes	No	0	2	4
443	R:R:L216	R:R:T200	1.47	Yes	No	0	2	3
444	R:R:D195	R:R:V191	1.46	No	No	0	7	7
445	R:R:D195	R:R:T146	1.45	No	No	0	7	7
446	R:R:K132	R:R:K205	1.44	No	No	0	2	4
447	R:R:E55	R:R:T54	1.41	No	No	0	4	1
448	R:R:L49	R:R:L50	1.38	No	No	0	2	3
449	R:R:L151	R:R:L394	1.38	No	Yes	0	5	5
450	R:R:L313	R:R:L316	1.38	No	No	0	3	3
451	R:R:L255	R:R:N251	1.37	No	No	0	5	7
452	R:R:E133	R:R:K132	1.35	No	No	0	2	2
453	R:R:E410	R:R:K168	1.35	No	No	0	8	8
454	R:R:A314	R:R:Y239	1.33	No	Yes	0	8	8
455	R:R:R261	R:R:S262	1.32	No	No	0	5	5
456	R:R:D103	R:R:Q105	1.31	No	No	0	5	5
457	R:R:H340	R:R:L333	1.29	No	Yes	0	5	7
458	R:R:D370	R:R:H372	1.26	No	No	0	4	4
459	R:R:F289	R:R:L288	1.22	No	No	0	3	1
460	R:R:L333	R:R:R334	1.21	Yes	No	0	7	7
461	R:R:K35	R:R:Y84	1.19	No	Yes	0	4	5
462	R:R:L192	R:R:Y149	1.17	No	Yes	0	7	8
463	R:R:Q327	R:R:R324	1.17	No	No	0	8	8
464	R:R:K37	R:R:W36	1.16	No	Yes	0	3	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	H:H:?7	18.822	5	2	0
2	R:R:W36	4.43	5	0	6
3	R:R:Y39	6.99143	7	2	6
4	R:R:P53	3.87	5	2	3
5	R:R:R60	7.92	4	2	4
6	R:R:F62	5.386	5	0	7
7	R:R:D63	7.838	5	2	9
8	R:R:Y65	5.58	9	2	6
9	R:R:S66	4.04667	6	2	5
10	R:R:C67	4.7275	4	2	9
11	R:R:W68	6.83875	8	2	9
12	R:R:T71	5.154	5	2	7
13	R:R:P82	7.062	5	2	8
14	R:R:W83	7.635	4	0	2
15	R:R:Y84	6.36333	6	2	5
16	R:R:L85	4.186	5	2	6
17	R:R:P86	7.125	4	2	3
18	R:R:W87	9.464	5	2	3
19	R:R:V91	3.54	4	0	6
20	R:R:V96	3.846	5	2	7
21	R:R:F97	3.88333	6	7	5
22	R:R:K98	13.485	4	2	8
23	R:R:W106	8.09286	7	2	9
24	R:R:Q113	3.5	5	9	4
25	R:R:R116	7.3675	4	2	6
26	R:R:M123	4.9875	4	2	3
27	R:R:Y149	5.56	6	3	8
28	R:R:L156	4.105	4	0	8
29	R:R:R173	6.065	4	1	9
30	R:R:I176	5.866	5	1	9
31	R:R:H177	9.4575	4	1	9
32	R:R:L180	3.26714	7	1	9
33	R:R:F181	3.3775	8	1	8
34	R:R:F184	6.07	7	1	8
35	R:R:K187	5.855	4	0	8
36	R:R:Y202	5.94	5	2	1
37	R:R:I206	5.3125	4	5	4
38	R:R:T214	3.4375	4	0	1
39	R:R:L216	2.8325	4	0	2
40	R:R:R225	9.035	4	6	8
41	R:R:Q232	8.4825	4	11	7
42	R:R:N238	9.585	4	1	9
43	R:R:Y239	5.55833	6	0	8
44	R:R:W241	8.58714	7	1	9
45	R:R:V244	6.12	4	1	8
46	R:R:E245	9.054	5	1	9
47	R:R:Y248	6.85667	6	1	8
48	R:R:L252	5.56	5	1	8
49	R:R:F263	5.5675	4	1	5
50	R:R:F264	7.236	5	1	6
51	R:R:L268	6.752	5	1	5
52	R:R:W272	7.17833	6	1	9
53	R:R:P275	4.256	5	0	9
54	R:R:W295	7.904	5	6	9
55	R:R:W304	11.158	5	4	6
56	R:R:R308	12.118	5	4	6
57	R:R:F309	4.5325	4	4	4
58	R:R:F312	6.545	4	4	5
59	R:R:I315	3.9275	4	0	7
60	R:R:L333	2.5975	4	1	7
61	R:R:Y343	6.1525	4	1	7
62	R:R:F345	5.8425	4	1	7
63	R:R:L347	3.252	5	1	9
64	R:R:T351	4.5075	4	1	9
65	R:R:L354	4.3675	4	0	9
66	R:R:H361	5.906	5	1	8
67	R:R:F367	3.8075	4	4	5
68	R:R:Q374	7.8125	4	0	4
69	R:R:S390	4.18	4	3	9
70	R:R:Q392	3.68	5	1	9
71	R:R:L394	3.0225	4	0	5
72	R:R:V396	3.5	4	1	9
73	R:R:Y400	8.27875	8	1	8
74	R:R:C401	3.21	4	1	9
75	R:R:F402	3.85	4	1	9
76	W:W:?3	9.428	10	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F97	R:R:Q120	11.2193	3.51	Yes	No	0	5	5
2	R:R:Q120	R:R:R94	11.8692	22.2	No	No	0	5	5
3	R:R:R94	R:R:V91	13.1647	2.62	No	Yes	0	5	6
4	R:R:V91	R:R:W87	13.9117	4.9	Yes	Yes	0	6	3
5	R:R:L85	R:R:W87	86.5506	5.69	Yes	Yes	2	6	3
6	R:R:L85	R:R:P82	23.2669	4.93	Yes	Yes	2	6	8
7	R:R:P82	R:R:Y39	13.2618	5.56	Yes	Yes	2	8	6
8	R:R:L85	R:R:Y84	18.3538	4.69	Yes	Yes	2	6	5
9	R:R:Y39	R:R:Y84	13.4631	8.94	Yes	Yes	2	6	5
10	R:R:L47	R:R:R60	10.5357	8.5	No	Yes	2	5	4
11	R:R:C67	R:R:L47	11.3653	4.76	Yes	No	2	9	5
12	R:R:S66	R:R:W68	19.1209	3.71	Yes	Yes	2	5	9
13	R:R:A77	R:R:W68	11.5292	2.59	No	Yes	2	7	9
14	R:R:P72	R:R:T71	14.5558	5.25	No	Yes	2	1	7
15	R:R:W106	R:R:W68	23.062	2.81	Yes	Yes	2	9	9
16	R:R:T71	R:R:W106	14.4767	7.28	Yes	Yes	2	7	9
17	R:R:C58	R:R:W106	11.5709	15.67	No	Yes	2	9	9
18	R:R:S66	R:R:Y65	10.6485	6.36	Yes	Yes	2	5	6
19	R:R:D63	R:R:Y65	20.3848	2.3	Yes	Yes	2	9	6
20	R:R:M123	R:R:W87	94.7706	12.8	Yes	Yes	2	3	3
21	R:R:G125	R:R:M123	97.826	1.75	No	Yes	0	2	3
22	R:R:G125	R:R:T214	98.0805	3.64	No	Yes	0	2	1
23	R:R:I128	R:R:T214	98.8354	3.04	No	Yes	0	2	1
24	R:R:I128	R:R:V130	99.0841	1.54	No	No	0	2	1
25	R:R:V130	R:R:V134	92.8547	1.6	No	No	0	1	2
26	R:R:A135	R:R:V130	12.0015	1.7	No	No	0	3	1
27	R:R:A135	R:R:L210	11.5004	3.15	No	No	0	3	4
28	R:R:V134	R:R:Y138	94.235	2.52	No	No	0	2	5
29	R:R:F383	R:R:Y138	94.4047	2.06	No	No	0	5	5
30	R:R:F141	R:R:F383	94.3752	25.72	No	No	10	6	5
31	R:R:F141	R:R:M144	94.9417	6.22	No	No	0	6	6
32	R:R:F387	R:R:M144	95.1222	17.42	No	No	0	5	6
33	R:R:F387	R:R:S390	94.9144	3.96	No	Yes	3	5	9
34	R:R:S390	R:R:Y149	95.6865	5.09	Yes	Yes	3	9	8
35	R:R:K187	R:R:Y149	100	10.75	Yes	Yes	0	8	8
36	R:R:K187	R:R:N238	49.3526	5.6	Yes	Yes	0	8	9
37	R:R:F184	R:R:N238	37.556	22.96	Yes	Yes	1	8	9
38	R:R:K187	R:R:Q392	51.748	2.71	Yes	Yes	0	8	9
39	R:R:F184	R:R:Q392	37.8083	2.34	Yes	Yes	1	8	9
40	R:R:F184	R:R:L156	11.6112	2.44	Yes	Yes	0	8	8
41	R:R:F184	R:R:L180	52.3131	3.65	Yes	Yes	1	8	9
42	R:R:C401	R:R:F181	19.7988	2.79	Yes	Yes	1	9	8
43	R:R:C401	R:R:L163	16.7327	3.17	Yes	No	0	9	8
44	R:R:L163	R:R:N174	12.1863	5.49	No	No	0	8	9
45	R:R:L180	R:R:Y400	20.9168	2.34	Yes	Yes	1	9	8
46	R:R:L358	R:R:Q392	13.7866	7.99	No	Yes	0	9	9
47	R:R:L354	R:R:L358	15.3107	2.77	Yes	No	0	9	9
48	R:R:L354	R:R:Y400	11.4436	4.69	Yes	Yes	0	9	8
49	R:R:S183	R:R:W272	10.3991	2.47	No	Yes	1	9	9
50	R:R:W241	R:R:W272	11.1482	21.56	Yes	Yes	1	9	9
51	R:R:L180	R:R:W241	16.4609	2.28	Yes	Yes	1	9	9
52	R:R:S350	R:R:Y400	19.8585	7.63	No	Yes	1	9	8
53	R:R:S350	W:W:?3	17.5062	11.24	No	Yes	1	9	0
54	R:R:I355	R:R:L242	13.2503	4.28	No	No	0	8	9
55	R:R:C67	R:R:Y39	13.2136	4.03	Yes	Yes	2	9	6
56	R:R:L85	R:R:Y65	45.6006	2.34	Yes	Yes	2	6	6
57	R:R:K98	R:R:W106	11.4667	22.05	Yes	Yes	2	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:R173	R:R:Y343	5.14	1	Yes	Yes	9	7	2	2
R:R:N404	R:R:R173	6.03	0	No	Yes	9	9	1	2
R:R:F345	R:R:L329	8.53	1	Yes	No	7	9	1	2
R:R:L333	R:R:M338	4.24	1	Yes	No	7	5	2	2
R:R:F345	R:R:L333	3.65	1	Yes	Yes	7	7	1	2
R:R:F345	R:R:M338	3.73	1	Yes	No	7	5	1	2
R:R:R346	R:R:Y343	4.12	0	No	Yes	8	7	1	2
R:R:F345	W:W:?3	7.46	1	Yes	Yes	7	0	1	0
R:R:K405	R:R:R346	16.09	0	No	No	6	8	2	1
R:R:R346	W:W:?3	3.31	0	No	Yes	8	0	1	0
R:R:K349	W:W:?3	25.91	0	No	Yes	9	0	1	0
R:R:L399	R:R:S350	3	1	No	No	8	9	1	1
R:R:S350	R:R:Y400	7.63	1	No	Yes	9	8	1	2
R:R:S350	W:W:?3	11.24	1	No	Yes	9	0	1	0
R:R:T353	W:W:?3	20.06	0	No	Yes	8	0	1	0
R:R:L357	W:W:?3	2.83	0	No	Yes	9	0	1	0
R:R:L403	R:R:V398	2.98	1	No	No	5	6	1	2
R:R:L399	R:R:L403	4.15	1	No	No	8	5	1	1
R:R:L399	W:W:?3	9.42	1	No	Yes	8	0	1	0
R:R:L403	W:W:?3	2.83	1	No	Yes	5	0	1	0
R:R:N404	R:R:V407	5.91	0	No	No	9	9	1	2
R:R:N404	W:W:?3	9.34	0	No	Yes	9	0	1	0
R:R:L395	W:W:?3	1.88	0	No	Yes	6	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
63.64	Single	5VEX	NNC0640	5VEX-GLP-1-NNC0640
63.64	Single	6KK7	PubChem 68178630	6KK7-GLP-1-PubChem 68178630
61.54	Single	5XF1	NNC0640	5XF1-Glucagon-NNC0640
58.33	Single	5VEW	PF-06372222	5VEW-GLP-1-PF-06372222
58.33	Single	6KJV	PubChem 68178630	6KJV-GLP-1-PubChem 68178630
58.33	Single	6KK1	PubChem 68178630	6KK1-GLP-1-PubChem 68178630
47.06	Single	6LN2	PubChem 68178630	6LN2-GLP-1-PubChem 68178630
35.71	Single	8PJK	t7m	8PJK-5-HT_1A-ST171-t7m-Gi1/β1/γ1
33.33	Single	8PKM	t7m	8PKM-5-HT_1A-Befiradol-t7m-Gi1/β1/γ1
31.58	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
28.57	Single	7CA3	rac-BHFF	7CA3-GABA_B1, GABA_B2-rac-BHFF
27.27	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
26.67	Single	7C7Q	PubChem 7023848	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
26.32	Single	8TB7	PubChem 168510218	8TB7-GPR61-PubChem 168510218
23.08	Single	7EB2	rac-BHFF	7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
22.73	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
22.22	Single	8GW8	KHF	8GW8-PTH1-KHF-Gs/β1/γ2
20.00	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
20.00	Single	8JR9	PCO371	8JR9-PTH1-PCO371-chim(NtGi1-Gs)/β1/γ2
18.18	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
17.65	Single	5X7D	PubChem 129318963	5X7D-β₂-S-Carazolol-PubChem 129318963
16.67	Single	4PXF	Octyl-Beta-D-Glucopyranoside	4PXF-Rhodopsin-Octyl-β-D-Glucopyranoside-Arrestin1 Finger Loop
16.67	Single	6UO8	GS39783	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
16.67	Single	7DUQ	PubChem 156022738	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
16.67	Single	8JPF	PubChem 118610427	8JPF-NTS₁-Neurotensin-PubChem 118610427
13.33	Single	8Y69	Cholesterol	8Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
12.50	Single	5T1A	PubChem 68764898; PubChem 12093170	5T1A-CCR2-PubChem 68764898; PubChem 12093170
12.50	Single	8Y69	Cholesterol	8Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
11.11	Single	8XQS	Flufenamic acid	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
10.53	Single	8JPC	PubChem 118610427; GDP; Mg	8JPC-NTS₁-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
10.00	Single	7DUR	PubChem 156022738	7DUR-GLP-1-PubChem 156022738-Gs/β1/γ2
9.52	Single	8JPB	PubChem 118610427; GDP; Mg	8JPB-NTS₁-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
9.09	Single	5LWE	Vercirnon	5LWE-CCR9-Vercirnon
9.09	Single	7E14	PubChem 156022738	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
9.09	Single	7EVM	PubChem 156022738	7EVM-GLP-1-PubChem 156022738-Gs/β1/γ2
7.69	Single	8ZPM	Cholesterol	8ZPM-CXCR4-AMD070-Cholesterol
5.88	Single	7LD3	PubChem 25263603	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/β1/γ2
5.56	Single	8XQR	Flufenamic acid	8XQR-TAS2R14-Flufenamic acid-Gt3/β1/γ1
5.26	Single	8RQL	Flufenamic acid	8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
5.26	Single	8XQO	Aristolochic acid A	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
5.00	Single	7RBT	PubChem 163183774	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
5.00	Single	8XQL	Aristolochic acid A	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.76	Single	6LFL	PubChem 153466996	6LFL-CXCR2-PubChem 153466996
4.55	Single	8J20	AR420626	8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
4.00	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
3.85	Single	8FN0	PubChem 118610427	8FN0-NTS₁-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
3.85	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
3.85	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
3.85	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
3.85	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
3.70	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
3.45	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
3.45	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2

PDB Summary
PDB	5XEZ
Class	B1
SubFamily	Peptide
Type	Glucagon
SubType	Glucagon
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	NNC0640
Protein Partners	-
PDB Resolution	3
Date	2017-05-24
D.O.I.	10.1038/nature22363

Net Summary
I_min	2.06
Number of Linked Nodes	370
Number of Links	464
Number of Hubs	76
Number of Links mediated by Hubs	278
Number of Communities	12
Number of Nodes involved in Communities	119
Number of Links involved in Communities	187

Path Summary
Number Of Nodes in MetaPath	58
Number Of Links MetaPath	57
Number of Shortest Paths	213628
Length Of Smallest Path	3
Average Path Length	21.1619
Length of Longest Path	38
Minimum Path Strength	1.25
Average Path Strength	6.16173
Maximum Path Strength	34.48
Minimum Path Correlation	0.7
Average Path Correlation	0.96417
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	63.5449
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.9676
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• glucagon receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • amide binding • binding • peptide hormone binding • hormone binding • enzyme regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • hydrolase activity • guanyl ribonucleotide binding • GDP binding • purine ribonucleotide binding • ion binding • ribonucleoside triphosphate phosphatase activity • anion binding • molecular function regulator activity • heterocyclic compound binding • carbohydrate derivative binding • hydrolase activity, acting on acid anhydrides • catalytic activity • ribonucleotide binding • pyrophosphatase activity • GTPase activity • nucleoside-triphosphatase regulator activity • GTPase regulator activity • purine ribonucleoside triphosphate binding • guanyl-nucleotide exchange factor activity • nucleoside phosphate binding • purine nucleotide binding • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • small molecule binding • hydrolase activity, acting on glycosyl bonds • peptidoglycan muralytic activity • hydrolase activity, hydrolyzing O-glycosyl compounds • lysozyme activity • multicellular organismal process • system process • circulatory system process • regulation of blood pressure • biological regulation • regulation of biological quality • blood circulation • regulation of biosynthetic process • regulation of biological process • regulation of cellular process • positive regulation of biological process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process
Gene Ontology	Biological Process	• multicellular organismal process • system process • circulatory system process • regulation of blood pressure • biological regulation • regulation of biological quality • blood circulation • regulation of biosynthetic process • regulation of biological process • regulation of cellular process • positive regulation of biological process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • cellular process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • cellular response to stimulus • response to stimulus • signaling • response to endogenous stimulus • hormone-mediated signaling pathway • cell communication • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • signal transduction • cellular response to hormone stimulus • cellular response to nitrogen compound • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • carbohydrate metabolic process • energy derivation by oxidation of organic compounds • glycogen metabolic process • primary metabolic process • regulation of generation of precursor metabolites and energy • generation of precursor metabolites and energy • regulation of polysaccharide metabolic process • regulation of primary metabolic process • glucan metabolic process • polysaccharide metabolic process • energy reserve metabolic process • regulation of glycogen metabolic process • regulation of carbohydrate metabolic process • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to nutrient levels • response to nutrient levels • cellular response to stress • response to stress • response to starvation • cellular response to starvation • cell surface receptor signaling pathway • response to nutrient • localization • secretion by cell • exocytosis • transport • secretion • export from cell • establishment of localization • vesicle-mediated transport • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • biological process involved in interspecies interaction between organisms • response to other organism • defense response • response to external stimulus • response to biotic stimulus • defense response to bacterium • defense response to other organism • response to bacterium • response to external biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process • carbohydrate derivative metabolic process • aminoglycan catabolic process • macromolecule catabolic process • glycosaminoglycan catabolic process • aminoglycan metabolic process • peptidoglycan metabolic process • symbiont-mediated cytolysis of host cell • viral life cycle • disruption of cell in another organism • cytolysis • biological process involved in interaction with host • biological process involved in symbiotic interaction • viral release from host cell by cytolysis • exit from host cell • viral process • cytolysis in another organism • viral release from host cell • disruption of anatomical structure in another organism • symbiont-mediated killing of host cell • killing of cells of another organism • cell killing • cell wall organization or biogenesis • cell wall macromolecule catabolic process • cell wall macromolecule metabolic process • cellular anatomical structure • membrane • cell periphery • plasma membrane • membrane-bounded organelle • intracellular anatomical structure • endosome • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • cytoplasm
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • cell periphery • plasma membrane • membrane-bounded organelle • intracellular anatomical structure • endosome • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • cytoplasm • vesicle • host cellular component • host intracellular part • host cell cytoplasm • host cell part • host intracellular region
SCOP2	Domain Identifier	• FnI-like domain • G protein-coupled receptor-like
SCOP2	Family Identifier	• FnI-like domain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NAG
PDB Residues	H:H:?7 H:H:?8 H:H:?9 H:H:?10 H:H:?12 H:H:?13
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetyl-D-glucosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


Code	97V
PDB Residues	W:W:?3
Environment Details	Open EMBL-EBI Page
Code	97V
Name	4-{[(4-cyclohexylphenyl){[3-(methylsulfonyl)phenyl]carbamoyl}amino]methyl}-N-(1H-tetrazol-5-yl)benzamide
Synonyms
Identifier
Formula	C29 H31 N7 O4 S
Molecular Weight	573.666
SMILES
PubChem	23549991
Formal Charge	0
Total Atoms	72
Total Chiral Atoms	0
Total Bonds	76
Total Aromatic Bonds	23


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P47871
Sequence	>5XEZ_Chain_R G A P Q V M D F L F E K W K L Y G D Q C H H N L S L L P P P T E L V C N R T F D K Y S C W P D T P A N T T A N I S C P W Y L P W H H K V Q H R F V F K R C G P D G Q W V R G P R G Q P W R D A S Q C Q M D G E E I E V Q K E V A K M Y S S F Q V M Y T V G Y S L S L G A L L L A L A I L G G L S K L H C T R N A I H A N L F A S F V L K A S S V L V I D G L L R T R Y S Q K I G D D L S V S T W L S D G A V A G C R V A A V F M Q Y G I V A N Y C W L L V E G L Y L H N L L G L A E R S F F S L Y L G I G W G A P M L F V V P W A V V K C L F E N V Q C W T S N D N M G F W W I L R F P V F L A I L I N F F I F V R I V Q L L V A K L R A R Q M H H T D Y K F R L A K S T L T L I P L L G V H E V V F A F V T D E H A Q G T L R S A K L F F D L F L S S F Q G L L V A V L Y C F L N K E V Q S E L R R R W H R W R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9IVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839	chim(NtGi1-Gs)/β2/γ2	3.22	2024-11-13	10.1016/j.apsb.2024.09.002
	9IVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839		3.22	2024-11-13	10.1016/j.apsb.2024.09.002
	8YW4	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ22	3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW4 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-		3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW5	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.84	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW5 (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Retatrutide	-		2.84	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8WG8	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	Peptide	chim(NtGi1-Gs)/β1/γ2	2.71	2024-03-06	10.1038/s41421-024-00649-0
	8WG8 (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	Peptide		2.71	2024-03-06	10.1038/s41421-024-00649-0
	8WA3	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	2.86	2024-03-06	10.1038/s41421-024-00649-0
	8WA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		2.86	2024-03-06	10.1038/s41421-024-00649-0
	8WG7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.54	2024-03-06	10.1038/s41421-024-00649-0
	8WG7 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.54	2024-03-06	10.1038/s41421-024-00649-0
	8JIS	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-	chim(NtGi1-Gs)/β1/γ2	2.46	2023-11-08	10.1073/pnas.2303696120
	8JIS (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-		2.46	2023-11-08	10.1073/pnas.2303696120
	8ITM	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.13	2023-10-18	10.1073/pnas.2306145120
	8ITM (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.13	2023-10-18	10.1073/pnas.2306145120
	8ITL	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.23	2023-10-18	10.1073/pnas.2306145120
	8ITL (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.23	2023-10-18	10.1073/pnas.2306145120
	8JIR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-	chim(NtGi1-Gs)/β1/γ2	2.57	2023-09-06	10.1073/pnas.2303696120
	8JIR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-		2.57	2023-09-06	10.1073/pnas.2303696120
	8JIP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-	chim(NtGi1-Gs)/β1/γ2	2.85	2023-09-06	10.1073/pnas.2303696120
	8JIP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-		2.85	2023-09-06	10.1073/pnas.2303696120
	8JIT	B1	Peptide	Glucagon	Glucagon	Homo sapiens	MEDI0382	-	Gs/β1/γ2	2.91	2023-09-06	10.1073/pnas.2303696120
	8JIT (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	MEDI0382	-		2.91	2023-09-06	10.1073/pnas.2303696120
	8JRV	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-	Arrestin2	3.3	2023-08-16	10.1038/s41586-023-06420-x
	8JRU	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	-	Arrestin2	3.5	2023-08-16	10.1038/s41586-023-06420-x
	8FU6	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon derivative ZP3780	-	Gs/β1/γ2	2.9	2023-04-12	10.1016/j.cell.2023.02.028
	8FU6 (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon derivative ZP3780	-		2.9	2023-04-12	10.1016/j.cell.2023.02.028
	9IVG	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	chim(NtGi1-Gs)/β1/γ2	3	2024-11-27	10.1016/j.apsb.2024.09.002
	9IVG (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-		3	2024-11-27	10.1016/j.apsb.2024.09.002
	9J1P	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-	chim(NtGi1-Gs)/β1/γ2	2.99	2025-02-26	10.1021/jacs.4c12808
	9J1P (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-		2.99	2025-02-26	10.1021/jacs.4c12808
	8JIU	B1	Peptide	Glucagon	Glucagon	Homo sapiens	SAR425899	-	Gs/β1/γ2	2.76	2023-09-13	10.1073/pnas.2303696120
	8JIU (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	SAR425899	-		2.76	2023-09-13	10.1073/pnas.2303696120
	8JIQ	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-15	-	Gs/β1/γ2	3.4	2023-09-13	10.1073/pnas.2303696120
	8JIQ (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-15	-		3.4	2023-09-13	10.1073/pnas.2303696120
	7X8S	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-	Gs/β1/γ2	3.09	2022-06-29	10.1073/pnas.2200155119
	7X8S (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-		3.09	2022-06-29	10.1073/pnas.2200155119
	7X8R	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-	Gs/β1/γ2	2.61	2022-06-29	10.1073/pnas.2200155119
	7X8R (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-		2.61	2022-06-29	10.1073/pnas.2200155119
	7S15	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 134611223	-	-	3.8	2022-06-08	10.1021/acs.jmedchem.1c01856
	7RBT	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	PubChem 163183774	chim(NtGi1-Gs)/β1/γ2	3.08	2022-04-13	10.1073/pnas.2116506119
	7RBT (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	PubChem 163183774		3.08	2022-04-13	10.1073/pnas.2116506119
	7RA3	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	chim(NtGi1-Gs)/β1/γ2	3.24	2022-04-13	10.1073/pnas.2116506119
	7RA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		3.24	2022-04-13	10.1073/pnas.2116506119
	7RGP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2022-04-13	10.1073/pnas.2116506119
	7RGP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		2.9	2022-04-13	10.1073/pnas.2116506119
	7RG9	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-04-13	10.1073/pnas.2116506119
	7RG9 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.2	2022-04-13	10.1073/pnas.2116506119
	7V9L	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2022-04-06	10.1073/pnas.2106606118
	7V9L (No Gprot)	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	-	-		2.6	2022-04-06	10.1073/pnas.2106606118
	7VBH	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3	2022-04-06	10.1038/s41467-022-28683-0
	7VBH (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-		3	2022-04-06	10.1038/s41467-022-28683-0
	7VAB	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-03-02	10.1038/s41467-022-28683-0
	7VAB (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-		3.2	2022-03-02	10.1038/s41467-022-28683-0
	7FIY	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	10.1038/s41467-022-28683-0
	7FIY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	10.1038/s41467-022-28683-0
	7VBI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-	Gs/β1/γ2	3	2022-03-02	10.1038/s41467-022-28683-0
	7VBI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-		3	2022-03-02	10.1038/s41467-022-28683-0
	7FIM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	10.1038/s41467-022-28683-0
	7FIM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	10.1038/s41467-022-28683-0
	7V35	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3.5	2022-03-02	10.1038/s41467-022-28683-0
	7V35 (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-20	-		3.5	2022-03-02	10.1038/s41467-022-28683-0
	7FIN	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-	Gs/β1/γ2	3.1	2022-02-23	10.1038/s41467-022-28683-0
	7FIN (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-		3.1	2022-02-23	10.1038/s41467-022-28683-0
	7LLY	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-	Gs/β1/γ2	3.3	2022-01-12	10.1038/s41467-021-27760-0
	7LLY (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-		3.3	2022-01-12	10.1038/s41467-021-27760-0
	7LLL	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	3.7	2022-01-12	10.1038/s41467-021-27760-0
	7LLL (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		3.7	2022-01-12	10.1038/s41467-021-27760-0
	7S3I	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.51	2022-01-05	10.1038/s41589-021-00945-w
	7S3I (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.51	2022-01-05	10.1038/s41589-021-00945-w
	7S1M	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-	Gs/β1/γ2	2.41	2022-01-05	10.1038/s41589-021-00945-w
	7S1M (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-		2.41	2022-01-05	10.1038/s41589-021-00945-w
	7V9M	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	Somatoliberin	-	Gs/β1/γ2	3.29	2021-10-20	10.1073/pnas.2106606118
	7V9M (No Gprot)	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	Somatoliberin	-		3.29	2021-10-20	10.1073/pnas.2106606118
	7RTB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-	Gs/β1/γ2	2.14	2021-10-06	10.1016/j.bbrc.2021.09.016
	7RTB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-		2.14	2021-10-06	10.1016/j.bbrc.2021.09.016
	7EVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	2.5	2021-08-11	10.1038/s41467-021-24058-z
	7EVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		2.5	2021-08-11	10.1038/s41467-021-24058-z
	7DUR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	3.3	2021-08-11	10.1038/s41467-021-24058-z
	7DUR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		3.3	2021-08-11	10.1038/s41467-021-24058-z
	7DTY	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	Gs/β1/γ2	2.98	2021-08-04	10.7554/eLife.68719
	7DTY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		2.98	2021-08-04	10.7554/eLife.68719
	7KI1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-	Gs/β1/γ2	2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI1 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-		2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI0	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-	Gs/β1/γ2	2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI0 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-		2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7DUQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738	Gs/β1/γ2	2.5	2021-07-14	10.1038/s41467-021-24058-z
	7DUQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738		2.5	2021-07-14	10.1038/s41467-021-24058-z
	7E14	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738	Gs/β1/γ2	2.9	2021-07-07	10.1038/s41467-021-24058-z
	7E14 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738		2.9	2021-07-07	10.1038/s41467-021-24058-z
	7LCK	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	3.24	2021-01-20	10.1016/j.str.2021.04.008
	7LCJ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	2.82	2021-01-20	10.1016/j.str.2021.04.008
	7LCI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.9	2021-01-20	10.1016/j.str.2021.04.008
	7LCI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.9	2021-01-20	10.1016/j.str.2021.04.008
	7D68	B1	Peptide	Glucagon	GLP-2	Homo sapiens	GLP-2	-	Gs/β1/γ2	3	2020-12-16	10.1038/s41422-020-00442-0
	7D68 (No Gprot)	B1	Peptide	Glucagon	GLP-2	Homo sapiens	GLP-2	-		3	2020-12-16	10.1038/s41422-020-00442-0
	6XOX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-	chim(NtGi1-Gs)/β1/γ2	3.1	2020-11-18	10.1073/pnas.2014879117
	6XOX (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-		3.1	2020-11-18	10.1073/pnas.2014879117
	7CZ5	B1	Peptide	Glucagon	GHRH	Homo sapiens	Somatoliberin	-	Gs/β1/γ2	2.6	2020-11-18	10.1038/s41467-020-18945-0
	7CZ5 (No Gprot)	B1	Peptide	Glucagon	GHRH	Homo sapiens	Somatoliberin	-		2.6	2020-11-18	10.1038/s41467-020-18945-0
	7D3S	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	2.9	2020-11-04	10.1016/j.bbrc.2020.08.042
	7D3S (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		2.9	2020-11-04	10.1016/j.bbrc.2020.08.042
	6X1A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.5	2020-09-09	10.1016/j.molcel.2020.09.020
	6X1A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.5	2020-09-09	10.1016/j.molcel.2020.09.020
	6X19	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-	Gs/β1/γ2	2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X19 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-		2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X18	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X18 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	7C2E	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-	Gs/β1/γ2	4.2	2020-08-26	10.1038/s41422-020-0384-8
	7C2E (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-		4.2	2020-08-26	10.1038/s41422-020-0384-8
	6WPW	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon derivative ZP3780	-	Gs/β1/γ2	3.1	2020-08-12	10.1126/science.aba3373
	6WPW (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon derivative ZP3780	-		3.1	2020-08-12	10.1126/science.aba3373
	6WZG	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	2.3	2020-08-12	10.1038/s41467-020-17791-4
	6WZG (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		2.3	2020-08-12	10.1038/s41467-020-17791-4
	6WI9	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	4.3	2020-08-12	10.1038/s41467-020-17791-4
	6WI9 (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		4.3	2020-08-12	10.1038/s41467-020-17791-4
	6VCB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440	Gs/β1/γ2	3.3	2020-07-22	10.1038/s41589-020-0589-7
	6VCB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440		3.3	2020-07-22	10.1038/s41589-020-0589-7
	6WHC	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glu16 analog of GCG	-	Gs/β1/γ2	3.4	2020-05-27	10.1074/jbc.RA120.013793
	6WHC (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glu16 analog of GCG	-		3.4	2020-05-27	10.1074/jbc.RA120.013793
	6LML	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-	Gi1/β1/γ1	3.9	2020-04-01	10.1126/science.aaz5346
	6LML (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-		3.9	2020-04-01	10.1126/science.aaz5346
	6LMK	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-	Gs/β1/γ2	3.7	2020-04-01	10.1126/science.aaz5346
	6LMK (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-		3.7	2020-04-01	10.1126/science.aaz5346
	6LN2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	3.2	2020-03-18	10.1038/s41467-020-14934-5
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	10.1038/s41586-019-1902-z
	6KK7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	3.1	2019-11-13	10.1107/S2052252519013496
	6KK1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	2.8	2019-11-13	10.1107/S2052252519013496
	6KJV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	2.8	2019-11-13	10.1107/S2052252519013496
	6B3J	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-	Gs/β1/γ2	3.3	2018-02-21	10.1038/nature25773
	6B3J (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-		3.3	2018-02-21	10.1038/nature25773
	5YQZ	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon analogue	-	-	3	2018-01-17	10.1038/nature25153
	5NX2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	-	3.7	2017-06-14	10.1038/nature22800
	5VEW	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.7	2017-05-24	10.1038/nature22378
	5XF1	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	NNC0640	-	3.19	2017-05-24	10.1038/nature22363
	5XEZ	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	NNC0640	-	3	2017-05-24	10.1038/nature22363
	5VAI	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-	Gs/β1/γ2	4.1	2017-05-24	10.1038/nature22394
	5VAI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-		4.1	2017-05-24	10.1038/nature22394
	5VEX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	NNC0640	-	3	2017-05-17	10.1038/nature22378
	5EE7	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	MK0893	-	2.5	2016-04-20	10.1038/nature17414
	4L6R	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	-	-	3.3	2013-07-24	10.1038/nature12393

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 5XEZ.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.