Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:H1 5.295400
2L:L:Q3 6.3525420
3L:L:Y13 4.984500
4L:L:R18 8.525410
5L:L:Q20 6.8775400
6L:L:F22 4.636510
7L:L:W25 4.42410
8L:L:M27 3.7625400
9R:R:F33 5.13514
10R:R:Y39 6.55667616
11R:R:R60 5.8725404
12R:R:D63 6.224519
13R:R:Y65 8.13833616
14R:R:W68 6.86429719
15R:R:Y84 5.56167615
16R:R:W87 9.7175403
17R:R:K98 8.178518
18R:R:W106 10.5186719
19R:R:R116 8.3125416
20R:R:M123 6.915403
21R:R:Y138 5.6675405
22R:R:F141 5.766506
23R:R:Y145 6.19833627
24R:R:Y149 5.15167628
25R:R:L156 4.24833668
26R:R:L163 5.155408
27R:R:F181 4.465408
28R:R:F184 7.17167668
29R:R:K187 5.93408
30R:R:D195 8.16427
31R:R:R201 12.9725414
32R:R:Y202 7.524511
33R:R:W215 11.782512
34R:R:L216 4.15402
35R:R:V221 3.36514
36R:R:Q232 7.265447
37R:R:Y233 4.265409
38R:R:I235 5.8225405
39R:R:Y239 5.3525438
40R:R:W241 6.74571779
41R:R:Y248 8.5475408
42R:R:W272 6.45479
43R:R:P275 3.88609
44R:R:W282 8.2325449
45R:R:K286 10.09408
46R:R:T296 4.6225405
47R:R:W304 12.462546
48R:R:R308 11.305406
49R:R:I321 4.7425408
50R:R:L333 3.55487
51R:R:Y343 8.3025487
52R:R:L352 5.0125408
53R:R:H361 8.1475438
54R:R:K381 4.234507
55R:R:F384 4.98434
56R:R:D385 6.6325437
57R:R:C401 4.235409
58R:R:E410 6.0725408
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:H1 R:R:V311 58.64925.54YesNo008
2R:R:V311 R:R:Y239 56.98718.83NoYes088
3L:L:H1 R:R:I235 54.1987.95YesYes005
4L:L:Q3 R:R:I235 24.75415.49YesYes005
5L:L:Q3 R:R:Y149 13.11695.64YesYes208
6R:R:I235 R:R:K187 23.23944.36YesYes058
7R:R:K187 R:R:Y149 49.30393.58YesYes088
8L:L:Q3 R:R:V191 12.704410.03YesNo207
9L:L:H1 R:R:R308 13.0474.51YesYes006
10R:R:R308 R:R:W304 13.941126.99YesYes066
11R:R:D370 R:R:W304 14.03226.7NoYes446
12L:L:T5 R:R:K381 14.76064.5NoYes007
13L:L:F6 R:R:Y145 71.86926.19NoYes007
14R:R:Y145 R:R:Y149 61.92084.96YesYes278
15R:R:V191 R:R:Y145 12.92453.79NoYes277
16L:L:F6 R:R:Y138 72.23395.16NoYes005
17R:R:D370 R:R:R378 27.366511.91NoNo044
18L:L:D9 R:R:R378 27.4654.76NoNo004
19L:L:D9 R:R:Y138 28.09674.6NoYes005
20R:R:I235 R:R:Q232 23.06265.49YesYes057
21R:R:Q232 R:R:W282 21.09218.76YesYes479
22R:R:K286 R:R:W282 22.61518.12YesYes089
23L:L:Y13 R:R:Y138 1006.95YesYes005
24L:L:L14 L:L:Y13 46.97613.52NoYes000
25L:L:R17 L:L:Y13 54.27169.26NoYes000
26L:L:L14 R:R:Y202 46.796512.89NoYes001
27R:R:K286 R:R:W295 26.477927.85YesNo089
28R:R:R225 R:R:W295 26.914427.99NoNo089
29R:R:R225 R:R:V221 27.45213.92NoYes084
30R:R:R201 R:R:V221 28.59396.54YesYes144
31L:L:Q20 L:L:R17 53.75973.5YesNo000
32L:L:R18 R:R:Y202 51.65846.17YesYes101
33R:R:R201 R:R:W215 19.312223.99YesYes142
34L:L:R18 R:R:I206 60.00643.76YesNo104
35L:L:Q20 R:R:M123 53.04148.16YesYes003
36R:R:F33 R:R:L216 12.45124.87YesYes042
37R:R:L216 R:R:W215 13.0123.42YesYes022
38L:L:W25 R:R:I206 54.85543.52YesNo104
39R:R:M123 R:R:W87 50.986213.96YesYes033
40L:L:L26 L:L:W25 55.34626.83NoYes100
41L:L:L26 R:R:Y65 54.58937.03NoYes106
42R:R:L85 R:R:W87 47.23487.97NoYes063
43R:R:L85 R:R:Y84 47.04514.69NoYes065
44R:R:Y65 R:R:Y84 50.98433.97YesYes165
45R:R:F33 R:R:W36 10.7795.01YesNo146
46R:R:W36 R:R:Y84 10.94018.68NoYes165
47R:R:D63 R:R:Y65 46.25323.45YesYes196
48R:R:D63 R:R:W68 30.57647.82YesYes199
49R:R:D70 R:R:W68 22.57372.23NoYes049
50R:R:D70 R:R:R60 20.702613.1NoYes044
51R:R:S66 R:R:Y65 31.461313.99NoYes156
52R:R:S66 R:R:W68 30.56636.18NoYes159
53R:R:P52 R:R:R60 15.07834.32NoYes014
54R:R:P52 R:R:P53 11.31951.95NoNo013
55R:R:W106 R:R:W68 28.004614.06YesYes199
56R:R:D63 R:R:K98 14.82144.15YesYes198
57R:R:K98 R:R:W106 27.916218.57YesYes189
58R:R:R116 R:R:Y65 22.185114.4YesYes166
59R:R:K98 R:R:R116 14.83896.19YesYes186
60R:R:C58 R:R:W106 14.9535.22NoYes199
61R:R:Q105 R:R:W106 26.14274.38NoYes159
62R:R:D103 R:R:Q105 22.42453.92NoNo055
63R:R:D103 R:R:P102 18.69153.22NoNo051
64R:R:N74 R:R:P102 11.22018.15NoNo071
65R:R:K187 R:R:N238 47.389511.19YesNo089
66R:R:F184 R:R:N238 31.439216.92YesNo089
67R:R:F184 R:R:L156 21.70634.87YesYes688
68R:R:F181 R:R:L156 16.50924.87YesYes088
69R:R:C401 R:R:F181 10.71824.19YesYes098
70R:R:F184 R:R:L180 10.53044.87YesNo089
71R:R:E245 R:R:L180 10.20355.3NoNo099
72R:R:N238 R:R:S183 15.74314.47NoNo099
73R:R:S183 R:R:W241 15.33523.71NoYes099
74R:R:I315 R:R:Y239 44.33153.63NoYes378
75R:R:A314 R:R:Y239 10.49081.33NoYes088
76R:R:E362 R:R:I315 50.16114.1NoNo087
77R:R:E362 R:R:F319 48.173112.83NoNo087
78R:R:F319 R:R:F322 46.18324.29NoNo079
79R:R:F322 R:R:I355 16.20532.51NoNo098
80R:R:I325 R:R:I355 12.16482.94NoNo098
81R:R:F322 R:R:L352 28.19062.44NoYes098
82R:R:L352 R:R:T351 22.20632.95YesNo089
83R:R:L329 R:R:T351 20.19154.42NoNo099
84R:R:L329 R:R:L333 18.22192.77NoYes097
85R:R:L333 R:R:Y343 10.13175.86YesYes877
86R:R:K381 R:R:V364 12.25414.55YesNo076
87R:R:C58 R:R:G104 11.22011.96NoNo099
88L:L:T5 R:R:D370 13.359115.9NoNo404
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:H1 R:R:I235 7.95 0 Yes Yes 0 5 0 1
L:L:H1 R:R:R308 4.51 0 Yes Yes 0 6 0 1
L:L:H1 R:R:V311 5.54 0 Yes No 0 8 0 1
L:L:S2 R:R:D385 7.36 0 No Yes 0 7 0 1
L:L:Q3 R:R:Y149 5.64 2 Yes Yes 0 8 0 1
L:L:Q3 R:R:V191 10.03 2 Yes No 0 7 0 1
L:L:Q3 R:R:I235 5.49 2 Yes Yes 0 5 0 1
L:L:T5 R:R:W304 4.85 4 No Yes 0 6 0 1
L:L:T5 R:R:D370 15.9 4 No No 0 4 0 1
L:L:T5 R:R:K381 4.5 4 No Yes 0 7 0 1
L:L:F6 R:R:Y138 5.16 0 No Yes 0 5 0 1
L:L:F6 R:R:F141 6.43 0 No Yes 0 6 0 1
L:L:F6 R:R:Y145 6.19 0 No Yes 0 7 0 1
L:L:S8 R:R:N298 11.92 0 No No 0 6 0 1
L:L:D9 R:R:Y138 4.6 0 No Yes 0 5 0 1
L:L:D9 R:R:R378 4.76 0 No No 0 4 0 1
L:L:Y10 R:R:Y138 5.96 0 No Yes 0 5 0 1
L:L:Y10 R:R:Q142 11.27 0 No No 0 5 0 1
L:L:S11 R:R:T296 6.4 0 No Yes 0 5 0 1
L:L:S11 R:R:S297 6.52 0 No No 0 4 0 1
L:L:Y13 R:R:Y138 6.95 0 Yes Yes 0 5 0 1
L:L:L14 R:R:Y202 12.89 0 No Yes 0 1 0 1
L:L:D15 R:R:V28 7.3 0 No No 0 3 0 1
L:L:D15 R:R:Q293 3.92 0 No No 0 4 0 1
L:L:R18 R:R:Y202 6.17 1 Yes Yes 0 1 0 1
L:L:R18 R:R:Q204 8.18 1 Yes No 0 4 0 1
L:L:R18 R:R:I206 3.76 1 Yes No 0 4 0 1
L:L:R18 R:R:W215 15.99 1 Yes Yes 0 2 0 1
L:L:Q20 R:R:M123 8.16 0 Yes Yes 0 3 0 1
L:L:Q20 R:R:Q131 11.52 0 Yes No 0 3 0 1
L:L:F22 R:R:L32 4.87 1 Yes No 0 4 0 1
L:L:F22 R:R:F33 4.29 1 Yes Yes 0 4 0 1
L:L:F22 R:R:I206 3.77 1 Yes No 0 4 0 1
L:L:F22 R:R:V212 5.24 1 Yes No 0 3 0 1
L:L:W25 R:R:I206 3.52 1 Yes No 0 4 0 1
L:L:L26 R:R:Y65 7.03 1 No Yes 0 6 0 1
L:L:L26 R:R:Y84 3.52 1 No Yes 0 5 0 1
L:L:M27 R:R:Y65 5.99 0 Yes Yes 0 6 0 1
R:R:L32 R:R:P86 4.93 0 No No 4 3 1 2
R:R:F33 R:R:W36 5.01 1 Yes No 4 6 1 2
R:R:F33 R:R:K37 6.2 1 Yes No 4 3 1 2
R:R:F33 R:R:S213 5.28 1 Yes No 4 3 1 2
R:R:F33 R:R:L216 4.87 1 Yes Yes 4 2 1 2
R:R:K37 R:R:W36 6.96 1 No No 3 6 2 2
R:R:W36 R:R:Y84 8.68 1 No Yes 6 5 2 1
R:R:P82 R:R:Y39 9.74 1 No Yes 8 6 2 2
R:R:Y39 R:R:Y84 6.95 1 Yes Yes 6 5 2 1
R:R:D63 R:R:Y65 3.45 1 Yes Yes 9 6 2 1
R:R:D63 R:R:S66 7.36 1 Yes No 9 5 2 2
R:R:D63 R:R:R116 8.34 1 Yes Yes 9 6 2 2
R:R:S66 R:R:Y65 13.99 1 No Yes 5 6 2 1
R:R:Y65 R:R:Y84 3.97 1 Yes Yes 6 5 1 1
R:R:R116 R:R:Y65 14.4 1 Yes Yes 6 6 2 1
R:R:P82 R:R:Y84 5.56 1 No Yes 8 5 2 1
R:R:L85 R:R:Y84 4.69 0 No Yes 6 5 2 1
R:R:L85 R:R:W87 7.97 0 No Yes 6 3 2 2
R:R:P86 R:R:W87 10.81 0 No Yes 3 3 2 2
R:R:M123 R:R:W87 13.96 0 Yes Yes 3 3 1 2
R:R:M123 R:R:Q122 4.08 0 Yes No 3 3 1 2
R:R:F141 R:R:M137 6.22 0 Yes No 6 4 1 2
R:R:F141 R:R:S140 3.96 0 Yes No 6 4 1 2
R:R:F141 R:R:F383 8.57 0 Yes No 6 5 1 2
R:R:F141 R:R:L386 3.65 0 Yes No 6 7 1 2
R:R:D195 R:R:Q142 11.75 2 Yes No 7 5 2 1
R:R:Q142 R:R:R199 10.51 2 No No 5 4 1 2
R:R:Y145 R:R:Y149 4.96 2 Yes Yes 7 8 1 1
R:R:V191 R:R:Y145 3.79 2 No Yes 7 7 1 1
R:R:D195 R:R:Y145 9.2 2 Yes Yes 7 7 2 1
R:R:L386 R:R:Y145 10.55 0 No Yes 7 7 2 1
R:R:K187 R:R:Y149 3.58 0 Yes Yes 8 8 2 1
R:R:A188 R:R:Y149 5.34 0 No Yes 8 8 2 1
R:R:V191 R:R:Y149 7.57 2 No Yes 7 8 1 1
R:R:S390 R:R:Y149 3.82 0 No Yes 9 8 2 1
R:R:I235 R:R:K187 4.36 0 Yes Yes 5 8 1 2
R:R:D195 R:R:R199 8.34 2 Yes No 7 4 2 2
R:R:L198 R:R:T296 7.37 0 No Yes 6 5 2 1
R:R:R201 R:R:Y202 6.17 1 Yes Yes 4 1 2 1
R:R:R201 R:R:W215 23.99 1 Yes Yes 4 2 2 1
R:R:Q293 R:R:R201 15.19 1 No Yes 4 4 1 2
R:R:W215 R:R:Y202 6.75 1 Yes Yes 2 1 1 1
R:R:Q293 R:R:Y202 5.64 1 No Yes 4 1 1 1
R:R:Q204 R:R:W215 8.76 1 No Yes 4 2 1 1
R:R:L216 R:R:W215 3.42 0 Yes Yes 2 2 2 1
R:R:I235 R:R:Q232 5.49 0 Yes Yes 5 7 1 2
R:R:L307 R:R:Q232 6.65 4 No Yes 7 7 2 2
R:R:V311 R:R:Y239 8.83 0 No Yes 8 8 1 2
R:R:H361 R:R:Y239 7.62 3 Yes Yes 8 8 2 2
R:R:S297 R:R:V292 6.46 0 No No 4 4 1 2
R:R:N298 R:R:W304 19.21 0 No Yes 6 6 1 1
R:R:M301 R:R:R308 3.72 0 No Yes 5 6 2 1
R:R:L307 R:R:W304 4.56 4 No Yes 7 6 2 1
R:R:R308 R:R:W304 26.99 0 Yes Yes 6 6 1 1
R:R:D370 R:R:W304 6.7 4 No Yes 4 6 1 1
R:R:R308 R:R:W305 10 0 Yes No 6 7 1 2
R:R:D385 R:R:H361 8.82 3 Yes Yes 7 8 1 2
R:R:K381 R:R:V364 4.55 0 Yes No 7 6 1 2
R:R:F384 R:R:V364 3.93 3 Yes No 4 6 2 2
R:R:D385 R:R:V364 4.38 3 Yes No 7 6 1 2
R:R:F365 R:R:K381 4.96 0 No Yes 7 7 2 1
R:R:D370 R:R:R378 11.91 4 No No 4 4 1 1
R:R:K381 R:R:L382 5.64 0 Yes No 7 5 1 2
R:R:D385 R:R:F384 5.97 3 Yes Yes 7 4 1 2
L:L:M27 R:R:A118 3.22 0 Yes No 0 5 0 1
R:R:I194 R:R:T296 3.04 0 No Yes 6 5 2 1
L:L:Y13 R:R:A135 2.67 0 Yes No 0 3 0 1
L:L:Y13 R:R:V134 2.52 0 Yes No 0 2 0 1
R:R:T146 R:R:Y145 2.5 0 No Yes 7 7 2 1
L:L:W25 R:R:K64 2.32 1 Yes No 0 4 0 1
L:L:A19 R:R:V28 1.7 0 No No 0 3 0 1
R:R:A228 R:R:T296 1.68 0 No Yes 5 5 2 1
R:R:S211 R:R:V212 1.62 0 No No 4 3 2 1
R:R:K381 R:R:V368 1.52 0 Yes No 7 5 1 2
R:R:I128 R:R:M123 1.46 0 No Yes 2 3 2 1
R:R:E133 R:R:V134 1.43 0 No No 2 2 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 6LMK_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.42
Number of Linked Nodes 386
Number of Links 429
Number of Hubs 58
Number of Links mediated by Hubs 220
Number of Communities 8
Number of Nodes involved in Communities 68
Number of Links involved in Communities 93
Path Summary
Number Of Nodes in MetaPath 89
Number Of Links MetaPath 88
Number of Shortest Paths 191472
Length Of Smallest Path 3
Average Path Length 19.9923
Length of Longest Path 39
Minimum Path Strength 1.125
Average Path Strength 6.9134
Maximum Path Strength 27.92
Minimum Path Correlation 0.71
Average Path Correlation 0.958994
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.84615
Average % Of Corr. Nodes 56.8559
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 52.3415
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• monosaccharide metabolic process   • regulation of cellular process   • positive regulation of biological process   • gluconeogenesis   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • small molecule metabolic process   • regulation of carbohydrate metabolic process   • regulation of glucose metabolic process   • positive regulation of cellular process   • positive regulation of gluconeogenesis   • regulation of biosynthetic process   • carbohydrate metabolic process   • regulation of biological process   • small molecule biosynthetic process   • carbohydrate biosynthetic process   • biological regulation   • hexose metabolic process   • primary metabolic process   • monosaccharide biosynthetic process   • hexose biosynthetic process   • positive regulation of glucose metabolic process   • biosynthetic process   • regulation of gluconeogenesis   • metabolic process   • cellular process   • positive regulation of carbohydrate metabolic process   • regulation of carbohydrate biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • glucose metabolic process   • cellular response to stimulus   • positive regulation of cell communication   • positive regulation of signal transduction   • response to stimulus   • signaling   • regulation of signal transduction   • intracellular signal transduction   • cell communication   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • intracellular signaling cassette   • signal transduction   • regulation of signaling   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • MAPK cascade   • regulation of cell communication   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of signaling   • negative regulation of programmed cell death   • regulation of apoptotic process   • negative regulation of biological process   • regulation of programmed cell death   • cell death   • negative regulation of apoptotic process   • negative regulation of cellular process   • apoptotic process   • programmed cell death   • cellular response to nitrogen compound   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular response to hormone stimulus   • response to activity   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • negative regulation of execution phase of apoptosis   • regulation of execution phase of apoptosis   • execution phase of apoptosis   • behavior   • multicellular organismal process   • feeding behavior   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • cell-cell signaling   • regulation of protein transport   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • positive regulation of establishment of protein localization   • carbohydrate homeostasis   • establishment of localization in cell   • positive regulation of insulin secretion involved in cellular response to glucose stimulus   • positive regulation of insulin secretion   • positive regulation of peptide hormone secretion   • intracellular glucose homeostasis   • cellular response to carbohydrate stimulus   • chemical homeostasis   • response to glucose   • glucose homeostasis   • positive regulation of protein localization   • insulin secretion involved in cellular response to glucose stimulus   • cellular localization   • homeostatic process   • positive regulation of secretion by cell   • positive regulation of protein transport   • positive regulation of hormone secretion   • response to monosaccharide   • response to carbohydrate   • positive regulation of secretion   • cellular response to hexose stimulus   • intracellular chemical homeostasis   • cellular response to monosaccharide stimulus   • positive regulation of peptide secretion   • cellular response to glucose stimulus   • positive regulation of protein secretion   • response to hexose   • cellular homeostasis   • positive regulation of transport   • regulation of cellular localization   • regulation of insulin secretion involved in cellular response to glucose stimulus   • regulation of calcium ion import   • regulation of calcium ion transport   • positive regulation of calcium ion transport   • positive regulation of calcium ion import   • regulation of monoatomic ion transport   • calcium ion transport   • metal ion transport   • positive regulation of monoatomic ion transport   • monoatomic ion transport   • calcium ion import   • monoatomic cation transport   • regulation of metal ion transport   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • membrane-bounded organelle   • intracellular anatomical structure   • membrane-enclosed lumen   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle lumen   • endoplasmic reticulum lumen   • intracellular organelle   • organelle lumen   • organelle
Gene OntologyCellular Component• cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • membrane-bounded organelle   • intracellular anatomical structure   • membrane-enclosed lumen   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle lumen   • endoplasmic reticulum lumen   • intracellular organelle   • organelle lumen   • organelle   • endoplasmic reticulum   • cytoplasm   • extracellular region   • vesicle lumen   • intracellular vesicle   • cytoplasmic vesicle lumen   • secretory granule lumen   • cytoplasmic vesicle   • secretory granule   • secretory vesicle   • vesicle   • extracellular space   • glucagon receptor activity   • peptide receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • signaling receptor activity   • transmembrane signaling receptor activity   • amide binding   • binding   • peptide hormone binding   • hormone binding   • GTPase regulator activity   • enzyme regulator activity   • guanyl-nucleotide exchange factor activity   • nucleoside-triphosphatase regulator activity   • molecular function regulator activity   • multicellular organismal process   • system process   • circulatory system process   • regulation of blood pressure   • biological regulation   • regulation of biological quality   • blood circulation   • regulation of biosynthetic process   • regulation of biological process   • regulation of cellular process   • positive regulation of biological process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • positive regulation of metabolic process   • biosynthetic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • regulation of macromolecule biosynthetic process   • metabolic process   • cellular process   • positive regulation of macromolecule metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • positive regulation of cellular process   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular response to hormone stimulus   • carbohydrate metabolic process   • energy derivation by oxidation of organic compounds   • glycogen metabolic process   • primary metabolic process   • regulation of generation of precursor metabolites and energy   • generation of precursor metabolites and energy   • regulation of polysaccharide metabolic process   • regulation of primary metabolic process   • glucan metabolic process   • polysaccharide metabolic process   • energy reserve metabolic process   • regulation of glycogen metabolic process   • regulation of carbohydrate metabolic process   • signaling   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to nutrient levels   • response to nutrient levels   • cellular response to stress   • response to stress   • response to starvation   • cellular response to starvation   • cell surface receptor signaling pathway   • response to nutrient   • chemical homeostasis   • homeostatic process   • glucose homeostasis   • carbohydrate homeostasis   • protein binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • sensory perception of smell   • skeletal system development   • bone development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • coagulation   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • regulation of protein transport   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • cellular localization   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • renal system process   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • trans-Golgi network
SCOP2Domain Identifier• G protein-coupled receptor-like   • FnI-like domain   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• G protein-coupled receptor-like   • FnI-like domain   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP47871
Sequence
>6LMK_nogp_Chain_R
QVMDFLFEK WKLYGDQCH HNLSLLPPP TELVCNRTF DKYSCWPDT 
PANTTANIS CPWYLPWHH KVQHRFVFK RCGPDGQWV RGPRGQPWR 
DASQCQMDG EEIEVQKEV AKMYSSFQV MYTVGYSLS LGALLLALA 
ILGGLSKLH CTRNAIHAN LFASFVLKA SSVLVIDGL LRTRYSQKI 
GDDLSVSTW LSDGAVAGC RVAAVFMQY GIVANYCWL LVEGLYLHN 
LLGLATLPE RSFFSLYLG IGWGAPMLF VVPWAVVKC LFENVQCWT 
SNDNMGFWW ILRFPVFLA ILINFFIFV RIVQLLVAK LRARQMHHT 
DYKFRLAKS TLTLIPLLG VHEVVFAFV TDEHAQGTL RSAKLFFDL 
FLSSFQGLL VAVLYCFLN KEVQSELRR RWHRWRLG


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6ORVB1PeptideGlucagonGLP-1Homo sapiens-TT-OAD2Gs/β1/γ232020-01-08doi.org/10.1038/s41586-019-1902-z
6ORV (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-TT-OAD232020-01-08doi.org/10.1038/s41586-019-1902-z
7E14B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 156022738Gs/β1/γ22.92021-07-07doi.org/10.1038/s41467-021-24058-z
7E14 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 1560227382.92021-07-07doi.org/10.1038/s41467-021-24058-z
7DUQB1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 156022738Gs/β1/γ22.52021-07-14doi.org/10.1038/s41467-021-24058-z
7DUQ (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 1560227382.52021-07-14doi.org/10.1038/s41467-021-24058-z
7DURB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ23.32021-08-11doi.org/10.1038/s41467-021-24058-z
7DUR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227383.32021-08-11doi.org/10.1038/s41467-021-24058-z
7EVMB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ22.52021-08-11doi.org/10.1038/s41467-021-24058-z
7EVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227382.52021-08-11doi.org/10.1038/s41467-021-24058-z
5VEWB1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.72017-05-24doi.org/10.1038/nature22378
6LN2B1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-3.22020-03-18doi.org/10.1038/s41467-020-14934-5
6KJVB1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.82019-11-13doi.org/10.1107/S2052252519013496
6KK1B1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.82019-11-13doi.org/10.1107/S2052252519013496
6KK7B1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-3.12019-11-13doi.org/10.1107/S2052252519013496
8WG8B1PeptideGlucagonGlucagonHomo sapiens-Peptidechim(NtGi1-Gs)/β1/γ22.712024-03-06doi.org/10.1038/s41421-024-00649-0
8WG8 (No Gprot) B1PeptideGlucagonGlucagonHomo sapiens-Peptide2.712024-03-06doi.org/10.1038/s41421-024-00649-0
5VEXB1PeptideGlucagonGLP-1Homo sapiens-NNC0640-32017-05-17doi.org/10.1038/nature22378
5XEZB1PeptideGlucagonGlucagonHomo sapiens-NNC0640-32017-05-24doi.org/10.1038/nature22363
5XF1B1PeptideGlucagonGlucagonHomo sapiens-NNC0640-3.192017-05-24doi.org/10.1038/nature22363
5EE7B1PeptideGlucagonGlucagonHomo sapiens-MK0893-2.52016-04-20doi.org/10.1038/nature17414
7RBTB1PeptideGlucagonGIPHomo sapiensTirzepatideLSN3556672chim(NtGi1-Gs)/β1/γ23.082022-04-13doi.org/10.1073/pnas.2116506119
7RBT (No Gprot) B1PeptideGlucagonGIPHomo sapiensTirzepatideLSN35566723.082022-04-13doi.org/10.1073/pnas.2116506119
9IVMB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN3318839chim(NtGi1-Gs)/β2/γ23.222024-11-13doi.org/10.1016/j.apsb.2024.09.002
9IVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN33188393.222024-11-13doi.org/10.1016/j.apsb.2024.09.002
6VCBB1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN3160440Gs/β1/γ23.32020-07-22doi.org/10.1038/s41589-020-0589-7
6VCB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN31604403.32020-07-22doi.org/10.1038/s41589-020-0589-7
7CZ5B1PeptideGlucagonGHRHHomo sapiensSomatoliberin-Gs/β1/γ22.62020-11-18doi.org/10.1038/s41467-020-18945-0
7CZ5 (No Gprot) B1PeptideGlucagonGHRHHomo sapiensSomatoliberin-2.62020-11-18doi.org/10.1038/s41467-020-18945-0
7V9MB1PeptideGlucagonGHRH (SV1)Homo sapiensSomatoliberin-Gs/β1/γ23.292021-10-20doi.org/10.1073/pnas.2106606118
7V9M (No Gprot) B1PeptideGlucagonGHRH (SV1)Homo sapiensSomatoliberin-3.292021-10-20doi.org/10.1073/pnas.2106606118
7V9LB1PeptideGlucagonGHRH (SV1)Homo sapiens--chim(NtGi1-Gs)/β1/γ22.62022-04-06doi.org/10.1073/pnas.2106606118
7V9L (No Gprot) B1PeptideGlucagonGHRH (SV1)Homo sapiens--2.62022-04-06doi.org/10.1073/pnas.2106606118
8WA3B1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ22.862024-03-06doi.org/10.1038/s41421-024-00649-0
8WA3 (No Gprot) B1PeptideGlucagonGIPHomo sapiens--2.862024-03-06doi.org/10.1038/s41421-024-00649-0
7FINB1PeptideGlucagonGIPHomo sapiensPeptide-20; GGL-Gs/β1/γ23.12022-02-23doi.org/10.1038/s41467-022-28683-0
7FIN (No Gprot) B1PeptideGlucagonGIPHomo sapiensPeptide-20; GGL-3.12022-02-23doi.org/10.1038/s41467-022-28683-0
7FIYB1PeptideGlucagonGIPHomo sapiensTirzepatide-Gs/β1/γ23.42022-03-02doi.org/10.1038/s41467-022-28683-0
7FIY (No Gprot) B1PeptideGlucagonGIPHomo sapiensTirzepatide-3.42022-03-02doi.org/10.1038/s41467-022-28683-0
7VABB1PeptideGlucagonGIPHomo sapiensNon-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ23.22022-03-02doi.org/10.1038/s41467-022-28683-0
7VAB (No Gprot) B1PeptideGlucagonGIPHomo sapiensNon-Acylated Tirzepatide-3.22022-03-02doi.org/10.1038/s41467-022-28683-0
7RA3B1PeptideGlucagonGIPHomo sapiensGIP-chim(NtGi1-Gs)/β1/γ23.242022-04-13doi.org/10.1073/pnas.2116506119
7RA3 (No Gprot) B1PeptideGlucagonGIPHomo sapiensGIP-3.242022-04-13doi.org/10.1073/pnas.2116506119
8ITLB1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ23.232023-10-18doi.org/10.1073/pnas.2306145120
8ITL (No Gprot) B1PeptideGlucagonGIPHomo sapiens--3.232023-10-18doi.org/10.1073/pnas.2306145120
8ITMB1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ23.132023-10-18doi.org/10.1073/pnas.2306145120
8ITM (No Gprot) B1PeptideGlucagonGIPHomo sapiens--3.132023-10-18doi.org/10.1073/pnas.2306145120
7DTYB1PeptideGlucagonGIPHomo sapiensGIP-Gs/β1/γ22.982021-08-04doi.org/10.7554/eLife.68719
7DTY (No Gprot) B1PeptideGlucagonGIPHomo sapiensGIP-2.982021-08-04doi.org/10.7554/eLife.68719
8YW4B1PeptideGlucagonGIPHomo sapiensRetatrutide-chim(NtGi1-Gs)/β1/γ23.262024-09-18doi.org/10.1038/s41421-024-00700-0
8YW4 (No Gprot) B1PeptideGlucagonGIPHomo sapiensRetatrutide-3.262024-09-18doi.org/10.1038/s41421-024-00700-0
9IVGB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ232024-11-27doi.org/10.1016/j.apsb.2024.09.002
9IVG (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-32024-11-27doi.org/10.1016/j.apsb.2024.09.002
7RTBB1PeptideGlucagonGLP-1Homo sapiensPeptide-19-Gs/β1/γ22.142021-10-06doi.org/10.1016/j.bbrc.2021.09.016
7RTB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-19-2.142021-10-06doi.org/10.1016/j.bbrc.2021.09.016
7KI0B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-Gs/β1/γ22.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7KI0 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-2.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7KI1B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-Gs/β1/γ22.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7KI1 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-2.52021-08-04doi.org/10.1016/j.celrep.2021.109374
6X18B1PeptideGlucagonGLP-1Homo sapiensGLP-1-Gs/β1/γ22.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X18 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1-2.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X19B1PeptideGlucagonGLP-1Homo sapiensCHU-128-Gs/β1/γ22.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X19 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensCHU-128-2.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X1AB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.52020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X1A (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.52020-09-09doi.org/10.1016/j.molcel.2020.09.020
7LCIB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.92021-01-20doi.org/10.1016/j.str.2021.04.008
7LCI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.92021-01-20doi.org/10.1016/j.str.2021.04.008
7LCJB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--2.822021-01-20doi.org/10.1016/j.str.2021.04.008
7LCKB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--3.242021-01-20doi.org/10.1016/j.str.2021.04.008
7S15B1PeptideGlucagonGLP-1Homo sapiensPubChem 134611223--3.82022-06-08doi.org/10.1021/acs.jmedchem.1c01856
9J1PB1PeptideGlucagonGLP-1Homo sapiensg1:Ox-chim(NtGi1-Gs)/β1/γ22.992025-02-26doi.org/10.1021/jacs.4c12808
9J1P (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensg1:Ox-2.992025-02-26doi.org/10.1021/jacs.4c12808
5VAIB1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-Gs/β1/γ24.12017-05-24doi.org/10.1038/nature22394
5VAI (No Gprot) B1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-4.12017-05-24doi.org/10.1038/nature22394
5NX2B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)--3.72017-06-14doi.org/10.1038/nature22800
6B3JB1PeptideGlucagonGLP-1Homo sapiensExendin-P5-Gs/β1/γ23.32018-02-21doi.org/10.1038/nature25773
6B3J (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-P5-3.32018-02-21doi.org/10.1038/nature25773
8WG7B1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.542024-03-06doi.org/10.1038/s41421-024-00649-0
8WG7 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.542024-03-06doi.org/10.1038/s41421-024-00649-0
7C2EB1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-Gs/β1/γ24.22020-08-26doi.org/10.1038/s41422-020-0384-8
7C2E (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-4.22020-08-26doi.org/10.1038/s41422-020-0384-8
7LLLB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/β1/γ23.72022-01-12doi.org/10.1038/s41467-021-27760-0
7LLL (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-4-3.72022-01-12doi.org/10.1038/s41467-021-27760-0
7LLYB1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-Gs/β1/γ23.32022-01-12doi.org/10.1038/s41467-021-27760-0
7LLY (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-3.32022-01-12doi.org/10.1038/s41467-021-27760-0
7FIMB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-Gs/β1/γ23.42022-03-02doi.org/10.1038/s41467-022-28683-0
7FIM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-3.42022-03-02doi.org/10.1038/s41467-022-28683-0
7VBIB1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-Gs/β1/γ232022-03-02doi.org/10.1038/s41467-022-28683-0
7VBI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-32022-03-02doi.org/10.1038/s41467-022-28683-0
7VBHB1PeptideGlucagonGLP-1Homo sapiensPeptide-20-Gs/β1/γ232022-04-06doi.org/10.1038/s41467-022-28683-0
7VBH (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-20-32022-04-06doi.org/10.1038/s41467-022-28683-0
7S1MB1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-Gs/β1/γ22.412022-01-05doi.org/10.1038/s41589-021-00945-w
7S1M (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-2.412022-01-05doi.org/10.1038/s41589-021-00945-w
7S3IB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.512022-01-05doi.org/10.1038/s41589-021-00945-w
7S3I (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.512022-01-05doi.org/10.1038/s41589-021-00945-w
6XOXB1PeptideGlucagonGLP-1Homo sapiensOrforglipron-chim(NtGi1-Gs)/β1/γ23.12020-11-18doi.org/10.1073/pnas.2014879117
6XOX (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipron-3.12020-11-18doi.org/10.1073/pnas.2014879117
7RG9B1PeptideGlucagonGLP-1Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22022-04-13doi.org/10.1073/pnas.2116506119
7RG9 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.22022-04-13doi.org/10.1073/pnas.2116506119
7RGPB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-chim(NtGi1-Gs)/β1/γ22.92022-04-13doi.org/10.1073/pnas.2116506119
7RGP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-2.92022-04-13doi.org/10.1073/pnas.2116506119
7X8RB1PeptideGlucagonGLP-1Homo sapiensBOC5-Gs/β1/γ22.612022-06-29doi.org/10.1073/pnas.2200155119
7X8R (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensBOC5-2.612022-06-29doi.org/10.1073/pnas.2200155119
7X8SB1PeptideGlucagonGLP-1Homo sapiensWB4-24-Gs/β1/γ23.092022-06-29doi.org/10.1073/pnas.2200155119
7X8S (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensWB4-24-3.092022-06-29doi.org/10.1073/pnas.2200155119
8JIPB1PeptideGlucagonGLP-1Homo sapiensMEDI0382-chim(NtGi1-Gs)/β1/γ22.852023-09-06doi.org/10.1073/pnas.2303696120
8JIP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensMEDI0382-2.852023-09-06doi.org/10.1073/pnas.2303696120
8JIRB1PeptideGlucagonGLP-1Homo sapiensSAR425899-chim(NtGi1-Gs)/β1/γ22.572023-09-06doi.org/10.1073/pnas.2303696120
8JIR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSAR425899-2.572023-09-06doi.org/10.1073/pnas.2303696120
8JISB1PeptideGlucagonGLP-1Homo sapiensPeptide-15-chim(NtGi1-Gs)/β1/γ22.462023-11-08doi.org/10.1073/pnas.2303696120
8JIS (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-15-2.462023-11-08doi.org/10.1073/pnas.2303696120
8YW3B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-Gs/β1/γ22.682024-09-18doi.org/10.1038/s41421-024-00700-0
8YW3 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-2.682024-09-18doi.org/10.1038/s41421-024-00700-0
9EBNB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ23.442025-03-26doi.org/10.1073/pnas.2407574122
9EBN (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.442025-03-26doi.org/10.1073/pnas.2407574122
9EBOB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (ACPC18)-Gs/β1/γ23.132025-03-26doi.org/10.1073/pnas.2407574122
9EBO (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (ACPC18)-3.132025-03-26doi.org/10.1073/pnas.2407574122
9EBQB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ23.162025-03-26doi.org/10.1073/pnas.2407574122
9EBQ (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.162025-03-26doi.org/10.1073/pnas.2407574122
8YWFB1PeptideGlucagonGLP-1Homo sapiensRetatrutide-chim(NtGi1-Gs)/β1/γ22.742025-04-16To be published
8YWF (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-2.742025-04-16To be published
9BYOB1PeptideGlucagonGLP-1Homo sapiensExendin-3-Gs/β1/γ22.312025-06-11To be published
9BYO (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-3-2.312025-06-11To be published
9C0KB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/β1/γ22.722025-06-11To be published
9C0K (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-4-2.722025-06-11To be published
7D68B1PeptideGlucagonGLP-2Homo sapiensGLP-2-Gs/β1/γ232020-12-16doi.org/10.1038/s41422-020-00442-0
7D68 (No Gprot) B1PeptideGlucagonGLP-2Homo sapiensGLP-2-32020-12-16doi.org/10.1038/s41422-020-00442-0
8FU6B1PeptideGlucagonGlucagonHomo sapiensGlucagon derivative ZP3780-Gs/β1/γ22.92023-04-12doi.org/10.1016/j.cell.2023.02.028
8FU6 (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlucagon derivative ZP3780-2.92023-04-12doi.org/10.1016/j.cell.2023.02.028
4L6RB1PeptideGlucagonGlucagonHomo sapiens---3.32013-07-24doi.org/10.1038/nature12393
5YQZB1PeptideGlucagonGlucagonHomo sapiensGlucagon analogue--32018-01-17doi.org/10.1038/nature25153
7V35B1PeptideGlucagonGlucagonHomo sapiensPeptide-20-Gs/β1/γ23.52022-03-02doi.org/10.1038/s41467-022-28683-0
7V35 (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensPeptide-20-3.52022-03-02doi.org/10.1038/s41467-022-28683-0
8JRUB1PeptideGlucagonGlucagonHomo sapiens--Arrestin23.52023-08-16doi.org/10.1038/s41586-023-06420-x
8JRVB1PeptideGlucagonGlucagonHomo sapiensGlucagon-Arrestin23.32023-08-16doi.org/10.1038/s41586-023-06420-x
8JITB1PeptideGlucagonGlucagonHomo sapiensMEDI0382-Gs/β1/γ22.912023-09-06doi.org/10.1073/pnas.2303696120
8JIT (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensMEDI0382-2.912023-09-06doi.org/10.1073/pnas.2303696120
8JIQB1PeptideGlucagonGlucagonHomo sapiensPeptide-15-Gs/β1/γ23.42023-09-13doi.org/10.1073/pnas.2303696120
8JIQ (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensPeptide-15-3.42023-09-13doi.org/10.1073/pnas.2303696120
8JIUB1PeptideGlucagonGlucagonHomo sapiensSAR425899-Gs/β1/γ22.762023-09-13doi.org/10.1073/pnas.2303696120
8JIU (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensSAR425899-2.762023-09-13doi.org/10.1073/pnas.2303696120
6WHCB1PeptideGlucagonGlucagonHomo sapiensGlu16 analog of GCG-Gs/β1/γ23.42020-05-27doi.org/10.1074/jbc.RA120.013793
6WHC (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlu16 analog of GCG-3.42020-05-27doi.org/10.1074/jbc.RA120.013793
6LMKB1PeptideGlucagonGlucagonHomo sapiensGlucagon-Gs/β1/γ23.72020-04-01doi.org/10.1126/science.aaz5346
6LMK (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlucagon-3.72020-04-01doi.org/10.1126/science.aaz5346
6LMLB1PeptideGlucagonGlucagonHomo sapiensGlucagon-Gi1/β1/γ13.92020-04-01doi.org/10.1126/science.aaz5346
6LML (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlucagon-3.92020-04-01doi.org/10.1126/science.aaz5346
6WPWB1PeptideGlucagonGlucagonHomo sapiensGlucagon derivative ZP3780-Gs/β1/γ23.12020-08-12doi.org/10.1126/science.aba3373
6WPW (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlucagon derivative ZP3780-3.12020-08-12doi.org/10.1126/science.aba3373
8YW5B1PeptideGlucagonGlucagonHomo sapiensRetatrutide-Gs/β1/γ22.842024-09-18doi.org/10.1038/s41421-024-00700-0
8YW5 (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensRetatrutide-2.842024-09-18doi.org/10.1038/s41421-024-00700-0
7D3SB1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/β1/γ22.92020-11-04doi.org/10.1016/j.bbrc.2020.08.042
7D3S (No Gprot) B1PeptideGlucagonSecretinHomo sapiensSecretin-2.92020-11-04doi.org/10.1016/j.bbrc.2020.08.042
6WI9B1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/β1/γ24.32020-08-12doi.org/10.1038/s41467-020-17791-4
6WI9 (No Gprot) B1PeptideGlucagonSecretinHomo sapiensSecretin-4.32020-08-12doi.org/10.1038/s41467-020-17791-4
6WZGB1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/β1/γ22.32020-08-12doi.org/10.1038/s41467-020-17791-4
6WZG (No Gprot) B1PeptideGlucagonSecretinHomo sapiensSecretin-2.32020-08-12doi.org/10.1038/s41467-020-17791-4




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