psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P89	R:R:Q30	6.32	Yes	No	0	3	5
2	R:R:E34	R:R:T31	2.82	No	No	0	5	5
3	R:R:R289	R:R:T31	5.17	Yes	No	0	4	5
4	R:R:E34	R:R:R38	16.28	No	No	0	5	5
5	R:R:L35	R:R:P89	3.28	No	Yes	0	5	3
6	L:L:F22	R:R:L35	7.31	Yes	No	0	0	5
7	L:L:F22	R:R:Y36	9.28	Yes	No	0	0	3
8	R:R:F65	R:R:W39	7.02	No	Yes	0	7	6
9	R:R:W39	R:R:Y87	13.5	Yes	Yes	2	6	4
10	L:L:F22	R:R:W39	6.01	Yes	Yes	2	0	6
11	L:L:L26	R:R:W39	12.53	Yes	Yes	2	0	6
12	R:R:E40	R:R:R43	10.47	No	No	0	3	4
13	R:R:R41	R:R:W86	7	No	Yes	0	5	1
14	R:R:V69	R:R:Y42	3.79	Yes	Yes	2	5	7
15	R:R:C70	R:R:Y42	4.03	No	Yes	0	9	7
16	R:R:P85	R:R:Y42	9.74	Yes	Yes	2	8	7
17	R:R:W86	R:R:Y42	5.79	Yes	Yes	0	1	7
18	R:R:Y42	R:R:Y87	7.94	Yes	Yes	2	7	4
19	R:R:F65	R:R:R43	10.69	No	No	0	7	4
20	R:R:E45	R:R:W86	10.9	No	Yes	0	4	1
21	R:R:C46	R:R:F65	5.59	No	No	0	8	7
22	R:R:C46	R:R:C70	7.28	No	No	0	8	9
23	R:R:A60	R:R:Y73	4	No	No	0	4	4
24	R:R:A60	R:R:P76	3.74	No	No	0	4	4
25	R:R:C103	R:R:C61	7.28	No	No	0	9	9
26	R:R:D66	R:R:W71	7.82	No	Yes	2	9	9
27	R:R:D66	R:R:R101	3.57	No	No	2	9	8
28	R:R:D66	R:R:R113	8.34	No	No	0	9	6
29	R:R:V69	R:R:Y68	3.79	Yes	Yes	2	5	5
30	R:R:Y68	R:R:Y87	2.98	Yes	Yes	2	5	4
31	R:R:R113	R:R:Y68	3.09	No	Yes	0	6	5
32	R:R:H115	R:R:Y68	8.71	No	Yes	2	7	5
33	L:L:I27	R:R:Y68	3.63	No	Yes	2	0	5
34	R:R:V69	R:R:W71	6.13	Yes	Yes	2	5	9
35	R:R:A82	R:R:V69	3.39	No	Yes	2	5	5
36	R:R:P85	R:R:V69	5.3	Yes	Yes	2	8	5
37	R:R:A82	R:R:W71	6.48	No	Yes	2	5	9
38	R:R:V99	R:R:W71	4.9	No	Yes	0	7	9
39	R:R:R101	R:R:W71	13	No	Yes	2	8	9
40	R:R:A74	R:R:C103	3.61	No	No	0	7	9
41	R:R:L100	R:R:T79	2.95	No	No	0	4	5
42	R:R:F98	R:R:R81	13.9	No	No	0	3	4
43	R:R:C84	R:R:H91	2.95	Yes	No	0	9	5
44	R:R:C84	R:R:V94	3.42	Yes	No	0	9	3
45	R:R:C118	R:R:C84	7.28	No	Yes	0	9	9
46	R:R:P85	R:R:Y87	8.34	Yes	Yes	2	8	4
47	R:R:L88	R:R:P85	4.93	No	Yes	0	5	8
48	R:R:H91	R:R:W86	4.23	No	Yes	0	5	1
49	L:L:L26	R:R:Y87	3.52	Yes	Yes	2	0	4
50	R:R:L88	R:R:P89	3.28	No	Yes	0	5	3
51	R:R:P89	R:R:W90	10.81	Yes	Yes	0	3	4
52	L:L:Q19	R:R:P89	3.16	No	Yes	0	0	3
53	R:R:V94	R:R:W90	3.68	No	Yes	0	3	4
54	R:R:N120	R:R:W90	29.38	Yes	Yes	0	3	4
55	R:R:G97	R:R:Q117	4.93	No	No	0	6	4
56	R:R:F98	R:R:Q117	3.51	No	No	0	3	4
57	R:R:Q102	R:R:W112	14.24	No	No	0	4	5
58	R:R:D114	R:R:T116	7.23	No	No	0	8	6
59	L:L:I27	R:R:H115	10.61	No	No	2	0	7
60	R:R:N120	R:R:P121	6.52	Yes	No	0	3	2
61	R:R:E122	R:R:N120	3.94	No	Yes	0	2	3
62	R:R:N120	R:R:N124	6.81	Yes	No	0	3	1
63	R:R:E125	R:R:K123	4.05	No	No	0	3	3
64	R:R:F127	R:R:N124	6.04	No	No	0	2	1
65	L:L:K20	R:R:N124	5.6	No	No	0	0	1
66	R:R:F127	R:R:Q130	5.86	No	No	0	2	3
67	L:L:K20	R:R:L128	4.23	No	No	0	0	3
68	R:R:F371	R:R:Q130	8.2	No	No	0	4	3
69	L:L:D9	R:R:Q130	3.92	No	No	0	0	3
70	L:L:F6	R:R:L134	3.65	Yes	No	0	0	5
71	R:R:E135	R:R:Q138	5.1	No	No	0	3	5
72	R:R:G375	R:R:L137	3.42	No	No	0	5	6
73	R:R:Q138	R:R:Y141	4.51	No	Yes	0	5	7
74	L:L:Y10	R:R:Q138	12.4	No	No	0	0	5
75	R:R:I378	R:R:M140	2.92	No	No	0	8	6
76	R:R:T142	R:R:Y141	3.75	No	Yes	0	7	7
77	R:R:Y141	R:R:Y145	5.96	Yes	Yes	0	7	7
78	R:R:D191	R:R:Y141	8.05	No	Yes	0	7	7
79	R:R:I378	R:R:Y141	3.63	No	Yes	6	8	7
80	L:L:F6	R:R:Y141	7.22	Yes	Yes	6	0	7
81	R:R:L188	R:R:T142	4.42	No	No	0	7	7
82	R:R:F383	R:R:G144	4.52	No	No	0	6	8
83	R:R:A184	R:R:Y145	4	No	Yes	0	8	7
84	R:R:I187	R:R:Y145	8.46	No	Yes	0	7	7
85	R:R:L188	R:R:Y145	5.86	No	Yes	0	7	7
86	R:R:S382	R:R:Y145	8.9	No	Yes	0	9	7
87	L:L:E3	R:R:Y145	3.37	Yes	Yes	0	0	7
88	R:R:F386	R:R:L147	6.09	No	No	0	5	5
89	R:R:L152	R:R:S148	3	No	No	0	9	9
90	R:R:F386	R:R:T151	7.78	No	No	0	5	7
91	R:R:S389	R:R:T151	4.8	No	No	0	8	7
92	R:R:F180	R:R:L152	6.09	Yes	No	0	8	9
93	R:R:L152	R:R:S389	3	No	No	0	9	8
94	R:R:L153	R:R:M181	2.83	No	No	0	3	7
95	R:R:F394	R:R:L154	3.65	No	No	0	8	5
96	R:R:A155	R:R:S389	3.42	No	No	0	9	8
97	R:R:A155	R:R:C393	3.61	No	No	0	9	9
98	R:R:L156	R:R:T178	2.95	No	No	0	6	3
99	R:R:C393	R:R:I158	4.91	No	No	0	9	8
100	R:R:I174	R:R:L159	2.85	No	No	0	7	8
101	R:R:F162	R:R:L161	3.65	Yes	No	0	7	3
102	R:R:F162	R:R:L165	3.65	Yes	No	0	7	9
103	R:R:E402	R:R:F162	5.83	No	Yes	0	8	7
104	R:R:H166	R:R:R163	4.51	No	No	0	7	8
105	R:R:E402	R:R:R164	12.79	No	No	0	8	7
106	R:R:R164	R:R:R405	10.66	No	No	0	7	8
107	R:R:E398	R:R:L165	3.98	No	No	0	9	9
108	R:R:L165	R:R:V399	5.96	No	No	0	9	9
109	R:R:H166	R:R:Y171	3.27	No	No	0	7	6
110	R:R:C167	R:R:N170	4.72	No	No	0	8	9
111	R:R:T168	R:R:Y240	3.75	No	No	0	8	8
112	R:R:E253	R:R:T168	12.7	No	No	0	5	8
113	R:R:N170	R:R:R169	7.23	No	No	0	9	9
114	R:R:H173	R:R:R169	3.39	Yes	No	0	9	9
115	R:R:F256	R:R:Y171	5.16	No	No	0	5	6
116	R:R:H173	R:R:I172	3.98	Yes	Yes	3	9	9
117	R:R:E237	R:R:I172	6.83	Yes	Yes	3	9	9
118	R:R:F177	R:R:H173	3.39	No	Yes	0	9	9
119	R:R:E237	R:R:H173	11.08	Yes	Yes	3	9	9
120	R:R:H173	R:R:Y392	5.44	Yes	Yes	0	9	8
121	R:R:N175	R:R:W233	16.95	No	Yes	3	9	9
122	R:R:L260	R:R:N175	4.12	No	No	3	6	9
123	R:R:N175	R:R:W264	3.39	No	Yes	3	9	9
124	R:R:F180	R:R:L176	9.74	Yes	No	0	8	9
125	R:R:E237	R:R:L176	3.98	Yes	No	0	9	9
126	R:R:F180	R:R:N230	7.25	Yes	No	0	8	9
127	R:R:F180	R:R:G385	3.01	Yes	No	0	8	9
128	R:R:F180	R:R:V388	10.49	Yes	No	0	8	9
129	R:R:C226	R:R:L182	3.17	No	No	0	6	7
130	R:R:R183	R:R:V227	5.23	Yes	No	1	8	6
131	R:R:N230	R:R:R183	9.64	No	Yes	0	9	8
132	R:R:R183	R:R:Y231	5.14	Yes	Yes	1	8	8
133	R:R:R183	R:R:S381	5.27	Yes	No	1	8	5
134	L:L:Y1	R:R:R183	3.09	Yes	Yes	1	0	8
135	L:L:E3	R:R:R183	9.3	Yes	Yes	1	0	8
136	R:R:A186	R:R:T223	3.36	No	No	0	6	6
137	R:R:A186	R:R:C226	3.61	No	No	0	6	6
138	R:R:Q220	R:R:R190	8.18	No	No	0	5	6
139	R:R:R190	R:R:T223	9.06	No	No	0	6	6
140	L:L:T7	R:R:R190	14.23	No	No	0	0	6
141	R:R:A215	R:R:L193	3.15	No	No	0	3	5
142	R:R:E288	R:R:L194	9.28	Yes	No	0	6	7
143	R:R:P197	R:R:R196	2.88	Yes	No	4	4	3
144	L:L:Y10	R:R:R196	3.09	No	No	4	0	3
145	L:L:L14	R:R:R196	8.5	Yes	No	4	0	3
146	L:L:L14	R:R:P197	3.28	Yes	Yes	4	0	4
147	L:L:A18	R:R:P197	3.74	No	Yes	0	0	4
148	L:L:W25	R:R:Y200	15.43	No	No	0	0	4
149	R:R:L208	R:R:W209	4.56	No	No	0	4	4
150	R:R:C216	R:R:C286	3.64	No	No	7	9	9
151	R:R:N283	R:R:R217	10.85	No	No	1	6	8
152	R:R:R217	R:R:W287	5	No	Yes	1	8	9
153	R:R:Q220	R:R:Q224	3.84	No	Yes	1	5	6
154	R:R:Q220	R:R:W274	3.29	No	Yes	1	5	8
155	R:R:I221	R:R:V275	6.14	No	No	0	5	6
156	R:R:I221	R:R:W287	5.87	No	Yes	0	5	9
157	R:R:Q224	R:R:W274	6.57	Yes	Yes	1	6	8
158	R:R:I299	R:R:Q224	6.86	No	Yes	1	7	6
159	L:L:Y1	R:R:Q224	5.64	Yes	Yes	1	0	6
160	R:R:W264	R:R:Y225	8.68	Yes	Yes	0	9	8
161	L:L:Y1	R:R:V227	16.4	Yes	No	1	0	6
162	R:R:G228	R:R:P267	4.06	No	Yes	0	5	9
163	R:R:A229	R:R:W264	3.89	No	Yes	0	8	9
164	R:R:L234	R:R:N230	4.12	No	No	0	9	9
165	R:R:I303	R:R:Y231	7.25	No	Yes	0	7	8
166	R:R:I307	R:R:Y231	7.25	No	Yes	1	7	8
167	R:R:E354	R:R:Y231	4.49	No	Yes	1	7	8
168	R:R:P267	R:R:T232	12.24	Yes	No	0	9	6
169	R:R:V236	R:R:W233	6.13	No	Yes	0	8	9
170	R:R:G263	R:R:W233	9.85	No	Yes	0	9	9
171	R:R:W233	R:R:W264	14.99	Yes	Yes	3	9	9
172	R:R:L235	R:R:V239	2.98	Yes	No	0	8	7
173	R:R:L235	R:R:T306	7.37	Yes	No	0	8	7
174	R:R:I309	R:R:L235	2.85	No	Yes	0	6	8
175	R:R:L235	R:R:N310	9.61	Yes	No	0	8	9
176	R:R:V236	R:R:Y259	3.79	No	Yes	0	8	8
177	R:R:L262	R:R:V236	2.98	No	No	0	6	8
178	R:R:E237	R:R:L349	13.25	Yes	No	0	9	9
179	R:R:V239	R:R:Y259	3.79	No	Yes	0	7	8
180	R:R:L244	R:R:Y240	10.55	No	No	0	8	8
181	R:R:I317	R:R:L241	4.28	No	No	0	9	9
182	R:R:H242	R:R:V246	12.45	No	No	0	8	7
183	R:R:H242	R:R:I313	3.98	No	No	0	8	8
184	R:R:L247	R:R:S243	4.5	No	No	0	5	7
185	R:R:S243	R:R:S251	3.26	No	No	0	7	7
186	R:R:L244	R:R:S251	3	No	No	0	8	7
187	R:R:G250	R:R:L247	3.42	No	No	0	6	5
188	R:R:E252	R:R:H255	7.39	No	No	0	7	4
189	R:R:H255	R:R:Y259	5.44	No	Yes	0	4	8
190	R:R:R257	R:R:Y258	13.38	No	No	0	3	3
191	R:R:L260	R:R:W264	3.42	No	Yes	3	6	9
192	R:R:F270	R:R:P302	23.12	No	No	0	5	9
193	R:R:I272	R:R:P273	3.39	No	No	0	2	4
194	R:R:R278	R:R:W274	3	Yes	Yes	1	8	8
195	R:R:W274	R:R:W287	3.75	Yes	Yes	1	8	9
196	R:R:I298	R:R:W274	3.52	No	Yes	0	8	8
197	R:R:I299	R:R:W274	15.27	No	Yes	1	7	8
198	R:R:I295	R:R:V277	6.14	Yes	No	0	3	5
199	R:R:E282	R:R:R278	10.47	No	Yes	1	5	8
200	R:R:R278	R:R:W287	25.99	Yes	Yes	1	8	9
201	R:R:E282	R:R:T284	7.06	No	No	1	5	4
202	R:R:E282	R:R:E291	12.69	No	No	1	5	4
203	R:R:N283	R:R:W287	5.65	No	Yes	1	6	9
204	R:R:E291	R:R:T284	4.23	No	No	1	4	4
205	R:R:C286	R:R:E288	4.56	No	Yes	0	9	6
206	L:L:T7	R:R:E288	4.23	No	Yes	0	0	6
207	L:L:S11	R:R:E288	11.5	No	Yes	0	0	6
208	R:R:E291	R:R:R289	3.49	No	Yes	0	4	4
209	L:L:S11	R:R:R289	6.59	No	Yes	0	0	4
210	L:L:D15	R:R:R289	3.57	No	Yes	0	0	4
211	R:R:N290	R:R:W296	21.47	No	Yes	0	6	6
212	L:L:S8	R:R:N290	8.94	No	No	0	0	6
213	R:R:I295	R:R:V292	7.68	Yes	No	0	3	6
214	R:R:I299	R:R:W296	3.52	No	Yes	0	7	6
215	R:R:R300	R:R:W296	13	Yes	Yes	0	7	6
216	L:L:Y1	R:R:W296	2.89	Yes	Yes	0	0	6
217	R:R:E362	R:R:W297	6.54	No	No	0	5	7
218	R:R:L304	R:R:R300	7.29	No	Yes	8	4	7
219	R:R:E362	R:R:R300	10.47	No	Yes	8	5	7
220	L:L:T5	R:R:R300	5.17	No	Yes	0	0	7
221	R:R:P302	R:R:T301	3.5	No	No	0	9	4
222	R:R:E362	R:R:L304	7.95	No	No	8	5	4
223	R:R:E354	R:R:I307	4.1	No	No	1	7	7
224	R:R:I307	R:R:V355	3.07	No	No	0	7	5
225	R:R:F311	R:R:I315	5.02	No	No	0	6	5
226	R:R:F311	R:R:V355	14.42	No	No	0	6	5
227	R:R:I313	R:R:I317	2.94	No	No	0	8	9
228	R:R:F314	R:R:L318	7.31	Yes	No	0	9	7
229	R:R:F314	R:R:L346	6.09	Yes	No	9	9	9
230	R:R:F314	R:R:L350	3.65	Yes	No	9	9	9
231	R:R:F314	R:R:V352	14.42	Yes	No	0	9	6
232	R:R:I317	R:R:L346	2.85	No	No	0	9	9
233	R:R:L318	R:R:T343	4.42	No	No	0	7	9
234	R:R:I320	R:R:K324	2.91	No	No	0	8	9
235	R:R:L321	R:R:S342	3	No	No	0	9	9
236	R:R:L322	R:R:R326	8.5	No	No	0	5	7
237	R:R:L325	R:R:Y335	5.86	No	No	0	7	5
238	R:R:L325	R:R:L339	4.15	No	No	0	7	9
239	R:R:R336	R:R:Y335	9.26	No	No	0	6	5
240	R:R:L339	R:R:T343	2.95	No	No	0	9	9
241	R:R:F345	R:R:L391	10.96	No	No	0	8	7
242	R:R:F345	R:R:Y392	15.47	No	Yes	0	8	8
243	R:R:L346	R:R:L350	6.92	No	No	9	9	9
244	R:R:P348	R:R:V347	3.53	No	No	0	9	8
245	R:R:V347	R:R:V352	9.62	No	No	0	8	6
246	R:R:L349	R:R:Y392	19.93	No	Yes	0	9	8
247	R:R:G351	R:R:H353	3.18	No	Yes	0	9	8
248	R:R:E354	R:R:H353	11.08	No	Yes	0	7	8
249	R:R:H353	R:R:L380	6.43	Yes	No	0	8	7
250	R:R:H353	R:R:Q384	7.42	Yes	No	0	8	9
251	R:R:F357	R:R:V360	7.87	Yes	No	0	7	4
252	R:R:F357	R:R:T361	3.89	Yes	No	5	7	7
253	R:R:F357	R:R:L369	7.31	Yes	No	0	7	4
254	R:R:F357	R:R:K373	6.2	Yes	No	5	7	7
255	R:R:E377	R:R:F357	9.33	No	Yes	5	7	7
256	R:R:K373	R:R:T361	9.01	No	No	5	7	7
257	R:R:A365	R:R:E363	3.02	No	No	0	6	5
258	R:R:L369	R:R:R366	6.07	No	No	0	4	5
259	R:R:F371	R:R:R370	3.21	No	No	0	4	5
260	L:L:D9	R:R:R370	8.34	No	No	0	0	5
261	R:R:E377	R:R:K373	4.05	No	No	5	7	7
262	L:L:F6	R:R:L374	7.31	Yes	No	0	0	6
263	R:R:E377	R:R:F376	5.83	No	No	0	7	4
264	R:R:F376	R:R:L380	4.87	No	No	0	4	7
265	L:L:F6	R:R:I378	6.28	Yes	No	6	0	8
266	R:R:F379	R:R:F383	6.43	No	No	0	6	6
267	L:L:E3	R:R:S381	7.19	Yes	No	1	0	5
268	R:R:F386	R:R:V390	6.55	No	No	0	5	5
269	R:R:V388	R:R:Y392	5.05	No	Yes	0	9	8
270	R:R:I395	R:R:V390	3.07	No	No	0	5	5
271	R:R:I395	R:R:L391	2.85	No	No	0	5	7
272	R:R:C393	R:R:F394	4.19	No	No	0	9	8
273	R:R:N396	R:R:V399	5.91	No	No	0	9	9
274	R:R:I403	R:R:V399	3.07	No	No	0	5	9
275	R:R:H409	R:R:R405	6.77	No	No	0	7	8
276	R:R:R411	R:R:W407	5	No	No	0	4	5
277	L:L:?2	L:L:Y1	3.37	Yes	Yes	1	0	0
278	L:L:E3	L:L:Y1	7.86	Yes	Yes	1	0	0
279	L:L:G4	L:L:Y1	5.79	No	Yes	1	0	0
280	L:L:?2	L:L:E3	12.69	Yes	Yes	1	0	0
281	L:L:?2	L:L:G4	3.28	Yes	No	1	0	0
282	L:L:?2	L:L:T5	8.47	Yes	No	0	0	0
283	L:L:G4	L:L:T7	3.64	No	No	0	0	0
284	L:L:L14	L:L:Y10	4.69	Yes	No	4	0	0
285	L:L:?13	L:L:I12	5.47	Yes	No	0	0	0
286	L:L:?13	L:L:K16	5.4	Yes	No	0	0	0
287	L:L:?13	L:L:I17	5.47	Yes	No	0	0	0
288	L:L:D15	L:L:Q19	6.53	No	No	0	0	0
289	L:L:K20	L:L:Q24	4.07	No	No	0	0	0
290	L:L:F22	L:L:L26	9.74	Yes	Yes	2	0	0
291	R:R:C332	R:R:R333	2.79	No	No	0	6	6
292	R:R:C410	R:R:R413	2.79	No	No	0	4	4
293	R:R:P267	R:R:Y225	2.78	Yes	Yes	0	9	8
294	R:R:L241	R:R:L245	2.77	No	No	0	9	8
295	R:R:H353	R:R:V347	2.77	Yes	No	0	8	8
296	R:R:L159	R:R:N170	2.75	No	No	0	8	9
297	R:R:K397	R:R:Q400	2.71	No	No	0	5	8
298	R:R:A268	R:R:Y225	2.67	No	Yes	0	3	8
299	L:L:?13	L:L:L14	2.65	Yes	Yes	0	0	0
300	R:R:F98	R:R:S83	2.64	No	No	0	3	3
301	R:R:R338	R:R:S342	2.64	No	No	0	9	9
302	R:R:S243	R:R:Y259	2.54	No	Yes	0	7	8
303	R:R:V271	R:R:Y225	2.52	No	Yes	0	6	8
304	L:L:I17	R:R:R131	2.51	No	No	0	0	3
305	R:R:F371	R:R:I133	2.51	No	No	0	4	4
306	R:R:F162	R:R:I158	2.51	Yes	No	0	7	8
307	R:R:I295	R:R:R278	2.51	Yes	Yes	0	3	8
308	R:R:F379	R:R:M140	2.49	No	No	0	6	6
309	R:R:S179	R:R:W233	2.47	No	Yes	0	9	9
310	L:L:F6	R:R:L137	2.44	Yes	No	0	0	6
311	R:R:I295	R:R:Y281	2.42	Yes	No	0	3	3
312	R:R:I172	R:R:W233	2.35	Yes	Yes	3	9	9
313	R:R:E48	R:R:R44	2.33	No	No	0	3	5
314	R:R:K293	R:R:W297	2.32	No	No	0	5	7
315	R:R:H255	R:R:Y258	2.18	No	No	0	4	3
316	R:R:R411	R:R:R414	2.13	No	No	0	4	5
317	R:R:G249	R:R:G250	2.11	No	No	0	7	6
318	L:L:G29	L:L:G30	2.11	No	No	2	0	0
319	R:R:G198	R:R:P199	2.03	No	No	0	3	3
320	R:R:C84	R:R:G97	1.96	Yes	No	0	9	6
321	R:R:A32	R:R:G33	1.95	No	No	0	4	5
322	L:L:A28	L:L:G29	1.95	No	No	0	0	0
323	R:R:C216	R:R:P195	1.88	No	No	7	9	3
324	R:R:C286	R:R:P195	1.88	No	No	7	9	3
325	R:R:A32	R:R:P197	1.87	No	Yes	0	4	4
326	R:R:A75	R:R:P76	1.87	No	No	0	2	4
327	R:R:A266	R:R:P267	1.87	No	Yes	0	4	9
328	R:R:A358	R:R:P359	1.87	No	No	0	6	5
329	R:R:G63	R:R:S64	1.86	No	No	0	4	6
330	R:R:A74	R:R:A80	1.79	No	No	0	7	6
331	R:R:G238	R:R:I313	1.76	No	No	0	9	8
332	L:L:G29	R:R:M67	1.75	No	No	2	0	3
333	L:L:G30	R:R:M67	1.75	No	No	2	0	3
334	R:R:P302	R:R:T306	1.75	No	No	0	9	7
335	R:R:C226	R:R:V222	1.71	No	No	0	6	5
336	R:R:A294	R:R:V292	1.7	No	No	0	3	6
337	R:R:I298	R:R:P273	1.69	No	No	0	8	4
338	R:R:E252	R:R:G254	1.64	No	No	0	7	5
339	R:R:L387	R:R:P348	1.64	No	No	0	6	9
340	R:R:V139	R:R:V143	1.6	No	No	0	3	5
341	R:R:C216	R:R:L193	1.59	No	No	0	9	5
342	R:R:A219	R:R:L193	1.58	No	No	0	6	5
343	R:R:A358	R:R:L304	1.58	No	No	0	6	4
344	R:R:A372	R:R:L369	1.58	No	No	0	5	4
345	R:R:I320	R:R:V246	1.54	No	No	0	8	7
346	L:L:I27	L:L:V23	1.54	No	No	0	0	0
347	R:R:K397	R:R:S401	1.53	No	No	0	5	4
348	R:R:I174	R:R:T178	1.52	No	No	0	7	3
349	R:R:L188	R:R:S146	1.5	No	No	0	7	7
350	R:R:G367	R:R:R370	1.5	No	No	0	4	5
351	R:R:G406	R:R:R405	1.5	No	No	0	5	8
352	R:R:I272	R:R:I276	1.47	No	No	0	2	3
353	R:R:E135	R:R:V139	1.43	No	No	0	3	3
354	R:R:I315	R:R:L312	1.43	No	No	0	5	4
355	R:R:Q285	R:R:T284	1.42	No	No	0	3	4
356	R:R:G63	R:R:W71	1.41	No	Yes	0	4	9
357	L:L:L26	R:R:M67	1.41	Yes	No	2	0	3
358	R:R:E119	R:R:T116	1.41	No	No	0	1	6
359	R:R:L149	R:R:M181	1.41	No	No	0	6	7
360	R:R:L156	R:R:M181	1.41	No	No	0	6	7
361	L:L:G30	L:L:W25	1.41	No	No	0	0	0
362	R:R:L318	R:R:L321	1.38	No	No	0	7	9
363	R:R:L322	R:R:L339	1.38	No	No	0	5	9
364	R:R:A365	R:R:R366	1.38	No	No	0	6	5
365	R:R:D114	R:R:L100	1.36	No	No	0	8	4
366	R:R:D129	R:R:L132	1.36	No	No	0	1	3
367	R:R:L213	R:R:Q285	1.33	No	No	0	4	3
368	R:R:R326	R:R:S323	1.32	No	No	0	7	7
369	R:R:A80	R:R:W71	1.3	No	Yes	0	6	9
370	R:R:H409	R:R:L412	1.29	No	No	0	7	4
371	R:R:F256	R:R:I172	1.26	No	Yes	0	5	9
372	R:R:L100	R:R:R81	1.21	No	No	0	4	4
373	R:R:D72	R:R:Y73	1.15	No	No	0	6	4
374	R:R:L213	R:R:W209	1.14	No	No	0	4	4
375	R:R:H242	R:R:R316	1.13	No	No	0	8	8
376	R:R:R328	R:R:R338	1.07	No	No	0	6	9
377	R:R:R338	R:R:R341	1.07	No	No	0	9	9
378	R:R:H93	R:R:W90	1.06	No	Yes	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:W39	9.765	4	2	6
2	R:R:Y42	6.258	5	2	7
3	R:R:Y68	4.44	5	2	5
4	R:R:V69	4.48	5	2	5
5	R:R:W71	5.86286	7	2	9
6	R:R:C84	3.9025	4	0	9
7	R:R:P85	7.0775	4	2	8
8	R:R:W86	6.98	4	0	1
9	R:R:Y87	7.256	5	2	4
10	R:R:P89	5.37	5	0	3
11	R:R:W90	11.2325	4	0	4
12	R:R:N120	11.6625	4	0	3
13	R:R:Y141	5.52	6	6	7
14	R:R:Y145	6.09167	6	0	7
15	R:R:F162	3.91	4	0	7
16	R:R:I172	3.605	4	3	9
17	R:R:H173	5.456	5	3	9
18	R:R:F180	7.316	5	0	8
19	R:R:R183	6.27833	6	1	8
20	R:R:P197	2.9425	4	4	4
21	R:R:Q224	5.7275	4	1	6
22	R:R:Y225	4.1625	4	0	8
23	R:R:Y231	6.0325	4	1	8
24	R:R:W233	8.79	6	3	9
25	R:R:L235	5.7025	4	0	8
26	R:R:E237	8.785	4	3	9
27	R:R:Y259	3.89	4	0	8
28	R:R:W264	6.874	5	3	9
29	R:R:P267	5.2375	4	0	9
30	R:R:W274	5.9	6	1	8
31	R:R:R278	10.4925	4	1	8
32	R:R:W287	9.252	5	1	9
33	R:R:E288	7.3925	4	0	6
34	R:R:R289	4.705	4	0	4
35	R:R:I295	4.6875	4	0	3
36	R:R:W296	10.22	4	0	6
37	R:R:R300	8.9825	4	8	7
38	R:R:F314	7.8675	4	9	9
39	R:R:H353	6.176	5	0	8
40	R:R:F357	6.92	5	5	7
41	R:R:Y392	11.4725	4	0	8
42	L:L:Y1	6.43429	7	1	0
43	L:L:?2	6.9525	4	1	0
44	L:L:E3	8.082	5	1	0
45	L:L:F6	5.38	5	6	0
46	L:L:?13	4.7475	4	0	0
47	L:L:L14	4.78	4	4	0
48	L:L:F22	8.085	4	2	0
49	L:L:L26	6.8	4	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:D15	R:R:R289	97.225	3.57	No	Yes	0	0	4
2	L:L:D15	L:L:Q19	96.3327	6.53	No	No	0	0	0
3	L:L:Q19	R:R:P89	95.4041	3.16	No	Yes	0	0	3
4	L:L:F22	R:R:L35	17.9846	7.31	Yes	No	0	0	5
5	R:R:L35	R:R:P89	19.2397	3.28	No	Yes	0	5	3
6	R:R:L88	R:R:P89	39.1759	3.28	No	Yes	0	5	3
7	R:R:L88	R:R:P85	38.0042	4.93	No	Yes	0	5	8
8	R:R:P85	R:R:V69	22.3375	5.3	Yes	Yes	2	8	5
9	R:R:V69	R:R:W71	15.3185	6.13	Yes	Yes	2	5	9
10	R:R:F98	R:R:Q117	11.6911	3.51	No	No	0	3	4
11	R:R:G97	R:R:Q117	13.1203	4.93	No	No	0	6	4
12	R:R:C84	R:R:G97	14.5422	1.96	Yes	No	0	9	6
13	R:R:C84	R:R:V94	16.9726	3.42	Yes	No	0	9	3
14	R:R:V94	R:R:W90	18.2277	3.68	No	Yes	0	3	4
15	R:R:P89	R:R:W90	41.5083	10.81	Yes	Yes	0	3	4
16	R:R:N120	R:R:W90	22.7619	29.38	Yes	Yes	0	3	4
17	R:R:N120	R:R:N124	18.6267	6.81	Yes	No	0	3	1
18	R:R:F127	R:R:N124	13.055	6.04	No	No	0	2	1
19	R:R:F127	R:R:Q130	11.6331	5.86	No	No	0	2	3
20	R:R:Y141	R:R:Y145	51.7012	5.96	Yes	Yes	0	7	7
21	L:L:E3	R:R:Y145	61.8072	3.37	Yes	Yes	0	0	7
22	L:L:E3	L:L:Y1	22.5406	7.86	Yes	Yes	1	0	0
23	L:L:G4	L:L:Y1	81.6127	5.79	No	Yes	1	0	0
24	L:L:G4	L:L:T7	100	3.64	No	No	0	0	0
25	L:L:T7	R:R:E288	96.5141	4.23	No	Yes	0	0	6
26	L:L:S11	R:R:E288	90.7102	11.5	No	Yes	0	0	6
27	L:L:S11	R:R:R289	90.0319	6.59	No	Yes	0	0	4
28	L:L:?2	L:L:E3	18.2422	12.69	Yes	Yes	1	0	0
29	L:L:?2	L:L:G4	19.0583	3.28	Yes	No	1	0	0
30	R:R:Q138	R:R:Y141	32.4253	4.51	No	Yes	0	5	7
31	L:L:Y10	R:R:Q138	26.1716	12.4	No	No	0	0	5
32	R:R:L152	R:R:S389	27.2236	3	No	No	0	9	8
33	R:R:F180	R:R:L152	29.4508	6.09	Yes	No	0	8	9
34	R:R:F180	R:R:N230	95.9409	7.25	Yes	No	0	8	9
35	R:R:N230	R:R:R183	96.9929	9.64	No	Yes	0	9	8
36	L:L:Y1	R:R:R183	88.5918	3.09	Yes	Yes	1	0	8
37	R:R:I174	R:R:T178	11.1687	1.52	No	No	0	7	3
38	R:R:I174	R:R:L159	13.3815	2.85	No	No	0	7	8
39	R:R:L159	R:R:N170	15.5869	2.75	No	No	0	8	9
40	R:R:N170	R:R:R169	19.9761	7.23	No	No	0	9	9
41	R:R:H173	R:R:R169	22.1597	3.39	Yes	No	0	9	9
42	R:R:E237	R:R:H173	12.1772	11.08	Yes	Yes	3	9	9
43	R:R:E237	R:R:L176	59.6199	3.98	Yes	No	0	9	9
44	R:R:F180	R:R:L176	60.4142	9.74	Yes	No	0	8	9
45	R:R:H173	R:R:Y392	13.7442	5.44	Yes	Yes	0	9	8
46	R:R:V388	R:R:Y392	17.0923	5.05	No	Yes	0	9	8
47	R:R:F180	R:R:V388	17.8722	10.49	Yes	No	0	8	9
48	R:R:A155	R:R:C393	20.9627	3.61	No	No	0	9	9
49	R:R:A155	R:R:S389	22.1307	3.42	No	No	0	9	8
50	R:R:C393	R:R:I158	17.4151	4.91	No	No	0	9	8
51	R:R:F162	R:R:I158	16.2181	2.51	Yes	No	0	7	8
52	R:R:E237	R:R:I172	45.8648	6.83	Yes	Yes	3	9	9
53	R:R:I172	R:R:W233	44.3957	2.35	Yes	Yes	3	9	9
54	R:R:V236	R:R:W233	29.1062	6.13	No	Yes	0	8	9
55	R:R:V236	R:R:Y259	26.9443	3.79	No	Yes	0	8	8
56	R:R:S243	R:R:Y259	10.9983	2.54	No	Yes	0	7	8
57	R:R:W233	R:R:W264	12.1119	14.99	Yes	Yes	3	9	9
58	R:R:R190	R:R:T223	11.4771	9.06	No	No	0	6	6
59	R:R:R183	R:R:Y231	60.2474	5.14	Yes	Yes	1	8	8
60	R:R:E291	R:R:R289	11.7673	3.49	No	Yes	0	4	4
61	R:R:E282	R:R:E291	10.5231	12.69	No	No	1	5	4
62	R:R:E282	R:R:R278	15.5506	10.47	No	Yes	1	5	8
63	R:R:R278	R:R:W274	16.9581	3	Yes	Yes	1	8	8
64	L:L:L14	L:L:Y10	16.3922	4.69	Yes	No	4	0	0
65	R:R:Q224	R:R:W274	17.9919	6.57	Yes	Yes	1	6	8
66	R:R:E354	R:R:Y231	52.9273	4.49	No	Yes	1	7	8
67	R:R:I317	R:R:L346	12.5834	2.85	No	No	0	9	9
68	R:R:F314	R:R:L346	13.7623	6.09	Yes	No	9	9	9
69	R:R:F314	R:R:V352	32.3165	14.42	Yes	No	0	9	6
70	R:R:V347	R:R:V352	33.4119	9.62	No	No	0	8	6
71	R:R:H353	R:R:V347	36.6548	2.77	Yes	No	0	8	8
72	R:R:E354	R:R:H353	52.8475	11.08	No	Yes	0	7	8
73	L:L:Y1	R:R:W296	12.3767	2.89	Yes	Yes	0	0	6
74	R:R:R300	R:R:W296	11.4444	13	Yes	Yes	0	7	6
75	R:R:F314	R:R:L318	17.4151	7.31	Yes	No	0	9	7
76	R:R:L318	R:R:T343	10.1241	4.42	No	No	0	7	9
77	R:R:H353	R:R:L380	16.2181	6.43	Yes	No	0	8	7
78	R:R:E377	R:R:F357	10.066	9.33	No	Yes	5	7	7
79	R:R:E377	R:R:F376	13.8022	5.83	No	No	0	7	4
80	R:R:F376	R:R:L380	15.0138	4.87	No	No	0	4	7
81	L:L:E3	R:R:R183	25.5695	9.3	Yes	Yes	1	0	8
82	L:L:Y1	R:R:Q224	24.7787	5.64	Yes	Yes	1	0	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:P89	R:R:Q30	6.32	0	Yes	No	3	5	1	2
R:R:R289	R:R:T31	5.17	0	Yes	No	4	5	1	2
R:R:L35	R:R:P89	3.28	0	No	Yes	5	3	1	1
L:L:F22	R:R:L35	7.31	2	Yes	No	0	5	0	1
L:L:F22	R:R:Y36	9.28	2	Yes	No	0	3	0	1
R:R:F65	R:R:W39	7.02	0	No	Yes	7	6	2	1
R:R:W39	R:R:Y87	13.5	2	Yes	Yes	6	4	1	1
L:L:F22	R:R:W39	6.01	2	Yes	Yes	0	6	0	1
L:L:L26	R:R:W39	12.53	2	Yes	Yes	0	6	0	1
R:R:V69	R:R:Y42	3.79	2	Yes	Yes	5	7	2	2
R:R:P85	R:R:Y42	9.74	2	Yes	Yes	8	7	2	2
R:R:Y42	R:R:Y87	7.94	2	Yes	Yes	7	4	2	1
R:R:V69	R:R:Y68	3.79	2	Yes	Yes	5	5	2	1
R:R:Y68	R:R:Y87	2.98	2	Yes	Yes	5	4	1	1
R:R:R113	R:R:Y68	3.09	0	No	Yes	6	5	2	1
R:R:H115	R:R:Y68	8.71	2	No	Yes	7	5	1	1
L:L:I27	R:R:Y68	3.63	2	No	Yes	0	5	0	1
R:R:P85	R:R:V69	5.3	2	Yes	Yes	8	5	2	2
R:R:P85	R:R:Y87	8.34	2	Yes	Yes	8	4	2	1
R:R:L88	R:R:P85	4.93	0	No	Yes	5	8	2	2
L:L:L26	R:R:Y87	3.52	2	Yes	Yes	0	4	0	1
R:R:L88	R:R:P89	3.28	0	No	Yes	5	3	2	1
R:R:P89	R:R:W90	10.81	0	Yes	Yes	3	4	1	2
L:L:Q19	R:R:P89	3.16	0	No	Yes	0	3	0	1
R:R:N120	R:R:W90	29.38	0	Yes	Yes	3	4	2	2
L:L:I27	R:R:H115	10.61	2	No	No	0	7	0	1
R:R:N120	R:R:N124	6.81	0	Yes	No	3	1	2	1
R:R:F127	R:R:N124	6.04	0	No	No	2	1	2	1
L:L:K20	R:R:N124	5.6	0	No	No	0	1	0	1
R:R:F127	R:R:Q130	5.86	0	No	No	2	3	2	1
L:L:K20	R:R:L128	4.23	0	No	No	0	3	0	1
R:R:F371	R:R:Q130	8.2	0	No	No	4	3	2	1
L:L:D9	R:R:Q130	3.92	0	No	No	0	3	0	1
L:L:F6	R:R:L134	3.65	6	Yes	No	0	5	0	1
R:R:E135	R:R:Q138	5.1	0	No	No	3	5	2	1
R:R:G375	R:R:L137	3.42	0	No	No	5	6	2	1
R:R:Q138	R:R:Y141	4.51	0	No	Yes	5	7	1	1
L:L:Y10	R:R:Q138	12.4	4	No	No	0	5	0	1
R:R:I378	R:R:M140	2.92	6	No	No	8	6	1	2
R:R:T142	R:R:Y141	3.75	0	No	Yes	7	7	2	1
R:R:Y141	R:R:Y145	5.96	6	Yes	Yes	7	7	1	1
R:R:D191	R:R:Y141	8.05	0	No	Yes	7	7	2	1
R:R:I378	R:R:Y141	3.63	6	No	Yes	8	7	1	1
L:L:F6	R:R:Y141	7.22	6	Yes	Yes	0	7	0	1
R:R:L188	R:R:T142	4.42	0	No	No	7	7	2	2
R:R:A184	R:R:Y145	4	0	No	Yes	8	7	2	1
R:R:I187	R:R:Y145	8.46	0	No	Yes	7	7	2	1
R:R:L188	R:R:Y145	5.86	0	No	Yes	7	7	2	1
R:R:S382	R:R:Y145	8.9	0	No	Yes	9	7	2	1
L:L:E3	R:R:Y145	3.37	1	Yes	Yes	0	7	0	1
R:R:R183	R:R:V227	5.23	1	Yes	No	8	6	1	1
R:R:N230	R:R:R183	9.64	0	No	Yes	9	8	2	1
R:R:R183	R:R:Y231	5.14	1	Yes	Yes	8	8	1	2
R:R:R183	R:R:S381	5.27	1	Yes	No	8	5	1	1
L:L:Y1	R:R:R183	3.09	1	Yes	Yes	0	8	0	1
L:L:E3	R:R:R183	9.3	1	Yes	Yes	0	8	0	1
R:R:Q220	R:R:R190	8.18	1	No	No	5	6	2	1
R:R:R190	R:R:T223	9.06	0	No	No	6	6	1	2
L:L:T7	R:R:R190	14.23	0	No	No	0	6	0	1
R:R:E288	R:R:L194	9.28	0	Yes	No	6	7	1	2
R:R:P197	R:R:R196	2.88	4	Yes	No	4	3	1	1
L:L:Y10	R:R:R196	3.09	4	No	No	0	3	0	1
L:L:L14	R:R:R196	8.5	4	Yes	No	0	3	0	1
L:L:L14	R:R:P197	3.28	4	Yes	Yes	0	4	0	1
L:L:A18	R:R:P197	3.74	0	No	Yes	0	4	0	1
L:L:W25	R:R:Y200	15.43	0	No	No	0	4	0	1
R:R:Q220	R:R:Q224	3.84	1	No	Yes	5	6	2	1
R:R:Q220	R:R:W274	3.29	1	No	Yes	5	8	2	2
R:R:Q224	R:R:W274	6.57	1	Yes	Yes	6	8	1	2
R:R:I299	R:R:Q224	6.86	1	No	Yes	7	6	2	1
L:L:Y1	R:R:Q224	5.64	1	Yes	Yes	0	6	0	1
L:L:Y1	R:R:V227	16.4	1	Yes	No	0	6	0	1
R:R:I299	R:R:W274	15.27	1	No	Yes	7	8	2	2
R:R:C286	R:R:E288	4.56	7	No	Yes	9	6	2	1
L:L:T7	R:R:E288	4.23	0	No	Yes	0	6	0	1
L:L:S11	R:R:E288	11.5	0	No	Yes	0	6	0	1
R:R:E291	R:R:R289	3.49	1	No	Yes	4	4	2	1
L:L:S11	R:R:R289	6.59	0	No	Yes	0	4	0	1
L:L:D15	R:R:R289	3.57	0	No	Yes	0	4	0	1
R:R:N290	R:R:W296	21.47	0	No	Yes	6	6	1	1
L:L:S8	R:R:N290	8.94	0	No	No	0	6	0	1
R:R:I299	R:R:W296	3.52	1	No	Yes	7	6	2	1
R:R:R300	R:R:W296	13	8	Yes	Yes	7	6	1	1
L:L:Y1	R:R:W296	2.89	1	Yes	Yes	0	6	0	1
R:R:L304	R:R:R300	7.29	8	No	Yes	4	7	2	1
R:R:E362	R:R:R300	10.47	8	No	Yes	5	7	2	1
L:L:T5	R:R:R300	5.17	0	No	Yes	0	7	0	1
R:R:E362	R:R:L304	7.95	8	No	No	5	4	2	2
R:R:F371	R:R:R370	3.21	0	No	No	4	5	2	1
L:L:D9	R:R:R370	8.34	0	No	No	0	5	0	1
L:L:F6	R:R:L374	7.31	6	Yes	No	0	6	0	1
L:L:F6	R:R:I378	6.28	6	Yes	No	0	8	0	1
L:L:E3	R:R:S381	7.19	1	Yes	No	0	5	0	1
L:L:I17	R:R:R131	2.51	0	No	No	0	3	0	1
L:L:F6	R:R:L137	2.44	6	Yes	No	0	6	0	1
R:R:A32	R:R:P197	1.87	0	No	Yes	4	4	2	1
L:L:G29	R:R:M67	1.75	2	No	No	0	3	0	1
L:L:G30	R:R:M67	1.75	2	No	No	0	3	0	1
R:R:G367	R:R:R370	1.5	0	No	No	4	5	2	1
L:L:L26	R:R:M67	1.41	2	Yes	No	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7FIY_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.82
Number of Linked Nodes	345
Number of Links	378
Number of Hubs	49
Number of Links mediated by Hubs	182
Number of Communities	9
Number of Nodes involved in Communities	65
Number of Links involved in Communities	87

Path Summary
Number Of Nodes in MetaPath	83
Number Of Links MetaPath	82
Number of Shortest Paths	67989
Length Of Smallest Path	3
Average Path Length	15.4987
Length of Longest Path	35
Minimum Path Strength	1.07
Average Path Strength	6.00126
Maximum Path Strength	20.095
Minimum Path Correlation	0.7
Average Path Correlation	0.958815
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	65.8524
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.3388
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• response to stimulus • response to stress • response to wounding • response to axon injury • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • response to metal ion • response to chemical • response to calcium ion • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • negative adaptation of signaling pathway • negative regulation of signaling • negative regulation of biological process • desensitization of G protein-coupled receptor signaling pathway • regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • regulation of response to stimulus • adaptation of signaling pathway • regulation of cell communication • metabolic process • generation of precursor metabolites and energy • response to hexose • response to monosaccharide • response to carbohydrate • response to glucose • response to oxygen-containing compound • gastric inhibitory peptide signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • developmental process • multicellular organism development • multicellular organismal process • pancreas development • endocrine system development • anatomical structure development • animal organ development • endocrine pancreas development • system development • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • cell surface receptor signaling pathway • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to lipid • response to fatty acid • response to nutrient levels • response to nutrient • positive regulation of cell communication • positive regulation of establishment of protein localization • positive regulation of insulin secretion • positive regulation of peptide hormone secretion • positive regulation of protein localization • positive regulation of biological process • positive regulation of secretion by cell • positive regulation of protein transport • positive regulation of hormone secretion • positive regulation of secretion • positive regulation of cellular process • positive regulation of peptide secretion • positive regulation of protein secretion • positive regulation of transport • positive regulation of signaling • cellular anatomical structure • membrane • cell periphery • plasma membrane • peptide hormone receptor binding • protein binding • binding • corticotropin-releasing hormone receptor binding • signaling receptor binding • G protein-coupled receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • mu-type opioid receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • adrenergic receptor binding • D1 dopamine receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • ionotropic glutamate receptor binding • glutamate receptor binding • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • molecular function regulator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • insulin-like growth factor receptor binding • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • intracellular anatomical structure • cytoplasm • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding • response to ketone • response to prostaglandin • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• FnI-like domain • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• FnI-like domain • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	AIB
PDB Residues	L:L:?2 L:L:?13
Environment Details	Open EMBL-EBI Page
Code	AIB
Name	2-aminoisobutyric acid
Synonyms	α-aminoisobutyric acid
Identifier
Formula	C4 H9 N O2
Molecular Weight	103.12
SMILES
PubChem	5245672
Formal Charge	0
Total Atoms	16
Total Chiral Atoms	0
Total Bonds	15
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P48546
Sequence	>7FIY_nogp_Chain_R Q T A G E L Y Q R W E R Y R R E C Q E T A C N G S F D M Y V C W D Y A A P N A T A R A S C P W Y L P W H H H V A A G F V L R Q C G W R D H T Q C E N P E K N E A F L D Q R L I L E R L Q V M Y T V G Y S L S L A T L L L A L L I L S L F R R L H C T R N Y I H I N L F T S F M L R A A A I L S R D R L L P R P G P Y L L W N Q A L A A C R T A Q I V T Q Y C V G A N Y T W L L V E G V Y L H S L L V L V G G S E E G H F R Y Y L L L G W G A P A L F V I P W V I V R Y L Y E N T Q C W E R N E V K A I W W I I R T P I L M T I L I N F L I F I R I L G I L L S K L R T R C R D Y R L R L A R S T L F L V P L L G V H E V V F A P V T E E Q A R G A L R F A K L G F E I F L S S F Q G F L V S V L Y C F I N K E V Q S E I R R G W H H C R L R R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7RBT	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	LSN3556672	chim(NtGi1-Gs)/β1/γ2	3.08	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RBT (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	LSN3556672		3.08	2022-04-13	doi.org/10.1073/pnas.2116506119
	8WA3	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	2.86	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		2.86	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	7FIN	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-	Gs/β1/γ2	3.1	2022-02-23	doi.org/10.1038/s41467-022-28683-0
	7FIN (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-		3.1	2022-02-23	doi.org/10.1038/s41467-022-28683-0
	7FIY	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VAB	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VAB (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-		3.2	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7RA3	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	chim(NtGi1-Gs)/β1/γ2	3.24	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		3.24	2022-04-13	doi.org/10.1073/pnas.2116506119
	8ITL	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.23	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITL (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.23	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITM	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.13	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITM (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.13	2023-10-18	doi.org/10.1073/pnas.2306145120
	7DTY	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	Gs/β1/γ2	2.98	2021-08-04	doi.org/10.7554/eLife.68719
	7DTY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		2.98	2021-08-04	doi.org/10.7554/eLife.68719
	8YW4	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ2	3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW4 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-		3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0

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