psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E34	R:R:T31	7.06	No	No	0	5	5
2	R:R:R289	R:R:T31	6.47	Yes	No	0	4	5
3	L:L:Q19	R:R:L35	3.99	No	No	0	0	5
4	L:L:F22	R:R:L35	7.31	Yes	No	0	0	5
5	L:L:H18	R:R:Y36	5.44	Yes	No	0	0	3
6	L:L:F22	R:R:Y36	8.25	Yes	No	0	0	3
7	R:R:F65	R:R:W39	5.01	Yes	Yes	0	7	6
8	R:R:W39	R:R:Y87	8.68	Yes	Yes	3	6	4
9	R:R:Q204	R:R:W39	6.57	No	Yes	0	4	6
10	L:L:F22	R:R:W39	10.02	Yes	Yes	3	0	6
11	L:L:L26	R:R:W39	6.83	No	Yes	3	0	6
12	R:R:E40	R:R:R43	10.47	No	No	0	3	4
13	R:R:E45	R:R:R41	4.65	No	No	0	4	5
14	R:R:F65	R:R:Y42	5.16	Yes	Yes	0	7	7
15	R:R:P85	R:R:Y42	5.56	Yes	Yes	3	8	7
16	R:R:W86	R:R:Y42	5.79	No	Yes	0	1	7
17	R:R:Y42	R:R:Y87	13.9	Yes	Yes	3	7	4
18	R:R:F65	R:R:R43	6.41	Yes	No	0	7	4
19	R:R:E45	R:R:W86	7.63	No	No	0	4	1
20	R:R:C46	R:R:F65	5.59	No	Yes	0	8	7
21	R:R:C46	R:R:C70	7.28	No	No	0	8	9
22	R:R:C103	R:R:C61	7.28	No	No	0	9	9
23	R:R:N62	R:R:Y73	8.14	No	No	0	4	4
24	R:R:D66	R:R:W71	7.82	No	Yes	0	9	9
25	R:R:D66	R:R:R113	5.96	No	No	5	9	6
26	L:L:K30	R:R:D66	5.53	No	No	5	0	9
27	L:L:Q29	R:R:M67	17.67	No	No	0	0	3
28	R:R:C118	R:R:Y68	5.38	No	No	0	9	5
29	R:R:V69	R:R:W71	4.9	No	Yes	0	5	9
30	R:R:P85	R:R:V69	10.6	Yes	No	0	8	5
31	R:R:A82	R:R:W71	7.78	No	Yes	0	5	9
32	R:R:V99	R:R:W71	4.9	No	Yes	0	7	9
33	R:R:R101	R:R:W71	6	No	Yes	0	8	9
34	R:R:L100	R:R:T79	4.42	Yes	No	0	4	5
35	R:R:F98	R:R:R81	5.34	No	No	0	3	4
36	R:R:C84	R:R:V94	5.12	No	No	0	9	3
37	R:R:C118	R:R:C84	7.28	No	No	0	9	9
38	R:R:P85	R:R:Y87	6.95	Yes	Yes	3	8	4
39	R:R:L88	R:R:P85	4.93	No	Yes	0	5	8
40	R:R:H91	R:R:W86	5.29	No	No	0	5	1
41	R:R:L88	R:R:W90	6.83	No	Yes	0	5	4
42	R:R:P89	R:R:W90	9.46	No	Yes	0	3	4
43	R:R:V94	R:R:W90	6.13	No	Yes	0	3	4
44	R:R:N120	R:R:W90	22.6	No	Yes	6	3	4
45	R:R:P121	R:R:W90	4.05	No	Yes	6	2	4
46	R:R:H93	R:R:P121	4.58	No	No	0	4	2
47	R:R:G97	R:R:Q117	4.93	No	No	0	6	4
48	R:R:F98	R:R:Q117	4.68	No	No	0	3	4
49	R:R:D114	R:R:L100	8.14	No	Yes	0	8	4
50	L:L:K30	R:R:R101	8.66	No	No	0	0	8
51	R:R:Q102	R:R:W112	14.24	No	No	0	4	5
52	L:L:L27	R:R:R113	3.64	No	No	0	0	6
53	L:L:K30	R:R:R113	19.8	No	No	5	0	6
54	R:R:D114	R:R:T116	5.78	No	No	0	8	6
55	R:R:E119	R:R:H115	3.69	No	No	0	1	7
56	L:L:L27	R:R:H115	10.29	No	No	0	0	7
57	R:R:E119	R:R:T116	8.47	No	No	0	1	6
58	R:R:N120	R:R:P121	6.52	No	No	6	3	2
59	R:R:E122	R:R:N120	11.83	No	No	0	2	3
60	R:R:E125	R:R:K123	12.15	No	No	0	3	3
61	R:R:F127	R:R:N124	4.83	No	No	0	2	1
62	L:L:Q20	R:R:N124	11.88	No	No	0	0	1
63	R:R:F127	R:R:Q130	4.68	No	No	0	2	3
64	R:R:F371	R:R:Q130	8.2	No	No	0	4	3
65	R:R:E135	R:R:R131	8.14	No	No	0	3	3
66	L:L:M14	R:R:R131	9.93	No	No	0	0	3
67	L:L:I17	R:R:R131	3.76	No	No	0	0	3
68	L:L:F6	R:R:L134	6.09	Yes	No	0	0	5
69	L:L:Y10	R:R:L134	7.03	No	No	0	0	5
70	L:L:F6	R:R:L137	6.09	Yes	No	0	0	6
71	R:R:Q138	R:R:Y141	4.51	No	Yes	0	5	7
72	R:R:D191	R:R:Q138	9.14	No	No	0	7	5
73	L:L:Y10	R:R:Q138	4.51	No	No	0	0	5
74	R:R:F379	R:R:M140	3.73	No	No	0	6	6
75	R:R:Y141	R:R:Y145	3.97	Yes	Yes	0	7	7
76	R:R:I378	R:R:Y141	3.63	No	Yes	7	8	7
77	L:L:F6	R:R:Y141	8.25	Yes	Yes	7	0	7
78	R:R:R183	R:R:Y145	5.14	Yes	Yes	0	8	7
79	R:R:A184	R:R:Y145	4	No	Yes	0	8	7
80	R:R:I187	R:R:Y145	9.67	No	Yes	0	7	7
81	R:R:S382	R:R:Y145	7.63	No	Yes	0	9	7
82	R:R:F386	R:R:L147	6.09	No	No	0	5	5
83	R:R:F386	R:R:T151	7.78	No	No	0	5	7
84	R:R:S389	R:R:T151	4.8	No	No	0	8	7
85	R:R:F177	R:R:L152	4.87	No	No	0	9	9
86	R:R:L152	R:R:S389	6.01	No	No	0	9	8
87	R:R:I174	R:R:L156	4.28	No	No	0	7	6
88	R:R:L156	R:R:T178	4.42	No	No	0	6	3
89	R:R:C393	R:R:I158	4.91	No	No	0	9	8
90	R:R:L159	R:R:N170	4.12	No	No	0	8	9
91	R:R:I174	R:R:L159	5.71	No	No	0	7	8
92	R:R:F162	R:R:L165	6.09	No	No	0	7	9
93	R:R:E402	R:R:F162	17.49	No	No	0	8	7
94	R:R:E398	R:R:R164	11.63	No	No	0	9	7
95	R:R:E402	R:R:R164	19.77	No	No	0	8	7
96	R:R:E398	R:R:L165	3.98	No	No	0	9	9
97	R:R:L165	R:R:V399	7.45	No	No	0	9	9
98	R:R:H166	R:R:Y171	9.8	No	No	0	7	6
99	R:R:C167	R:R:N170	4.72	No	No	0	8	9
100	R:R:T168	R:R:Y240	7.49	No	Yes	0	8	8
101	R:R:N170	R:R:R169	12.05	No	No	0	9	9
102	R:R:H173	R:R:R169	4.51	No	No	0	9	9
103	R:R:F256	R:R:Y171	4.13	No	No	0	5	6
104	R:R:E237	R:R:I172	6.83	Yes	No	0	9	9
105	R:R:I172	R:R:Y240	3.63	No	Yes	0	9	8
106	R:R:F256	R:R:I172	3.77	No	No	0	5	9
107	R:R:E237	R:R:H173	11.08	Yes	No	0	9	9
108	R:R:H173	R:R:Y392	7.62	No	No	0	9	8
109	R:R:N175	R:R:W233	13.56	No	Yes	0	9	9
110	R:R:L260	R:R:N175	4.12	No	No	0	6	9
111	R:R:F180	R:R:L176	7.31	Yes	No	0	8	9
112	R:R:L176	R:R:L234	4.15	No	No	0	9	9
113	R:R:E237	R:R:L176	5.3	Yes	No	0	9	9
114	R:R:F177	R:R:V388	3.93	No	No	0	9	9
115	R:R:F180	R:R:N230	20.54	Yes	No	0	8	9
116	R:R:F180	R:R:Q384	9.37	Yes	No	0	8	9
117	R:R:F180	R:R:G385	4.52	Yes	No	0	8	9
118	R:R:R183	R:R:V227	9.15	Yes	No	0	8	6
119	R:R:N230	R:R:R183	9.64	No	Yes	0	9	8
120	R:R:R183	R:R:Y231	4.12	Yes	Yes	1	8	8
121	R:R:R183	R:R:S381	5.27	Yes	No	1	8	5
122	L:L:E3	R:R:R183	8.14	No	Yes	1	0	8
123	R:R:Q220	R:R:R190	8.18	No	Yes	0	5	6
124	R:R:R190	R:R:T223	10.35	Yes	No	0	6	6
125	L:L:I7	R:R:R190	11.27	No	Yes	0	0	6
126	R:R:D191	R:R:R196	4.76	No	No	0	7	3
127	R:R:L194	R:R:P195	4.93	No	No	0	7	3
128	R:R:E288	R:R:L194	3.98	Yes	No	0	6	7
129	R:R:G198	R:R:P199	4.06	No	No	0	3	3
130	L:L:H18	R:R:P199	4.58	Yes	No	0	0	3
131	R:R:D203	R:R:L201	5.43	No	No	0	3	2
132	R:R:L213	R:R:Q285	3.99	No	No	0	4	3
133	R:R:C216	R:R:C286	7.28	No	No	0	9	9
134	R:R:N283	R:R:R217	10.85	No	No	4	6	8
135	R:R:R217	R:R:W287	6	No	Yes	4	8	9
136	R:R:Q220	R:R:Q224	5.12	No	Yes	0	5	6
137	R:R:I221	R:R:V275	6.14	No	No	4	5	6
138	R:R:I221	R:R:W287	4.7	No	Yes	4	5	9
139	R:R:Q224	R:R:W274	6.57	Yes	Yes	1	6	8
140	R:R:Q224	R:R:W296	5.48	Yes	Yes	1	6	6
141	R:R:I299	R:R:Q224	4.12	No	Yes	1	7	6
142	L:L:Y1	R:R:Q224	9.02	Yes	Yes	1	0	6
143	R:R:W264	R:R:Y225	8.68	No	No	0	9	8
144	R:R:P267	R:R:Y225	5.56	Yes	No	0	9	8
145	L:L:Y1	R:R:V227	12.62	Yes	No	0	0	6
146	R:R:G228	R:R:P267	4.06	No	Yes	0	5	9
147	R:R:A229	R:R:W264	3.89	No	No	0	8	9
148	R:R:L234	R:R:N230	4.12	No	No	0	9	9
149	R:R:I303	R:R:Y231	12.09	No	Yes	0	7	8
150	R:R:I307	R:R:Y231	4.84	No	Yes	1	7	8
151	R:R:E354	R:R:Y231	5.61	Yes	Yes	1	7	8
152	R:R:G263	R:R:T232	3.64	No	No	0	9	6
153	R:R:P267	R:R:T232	12.24	Yes	No	0	9	6
154	R:R:V236	R:R:W233	4.9	No	Yes	0	8	9
155	R:R:G263	R:R:W233	7.04	No	Yes	0	9	9
156	R:R:W233	R:R:W264	16.87	Yes	No	0	9	9
157	R:R:L235	R:R:T306	7.37	Yes	No	0	8	7
158	R:R:L235	R:R:N310	6.87	Yes	No	0	8	9
159	R:R:V236	R:R:Y259	3.79	No	Yes	0	8	8
160	R:R:L262	R:R:V236	4.47	No	No	0	6	8
161	R:R:E237	R:R:L349	11.93	Yes	No	0	9	9
162	R:R:V239	R:R:Y259	3.79	No	Yes	0	7	8
163	R:R:L244	R:R:Y240	9.38	No	Yes	0	8	8
164	R:R:Y240	R:R:Y259	4.96	Yes	Yes	0	8	8
165	R:R:L241	R:R:L245	4.15	No	No	2	9	8
166	R:R:I317	R:R:L241	4.28	Yes	No	2	9	9
167	R:R:H242	R:R:V246	12.45	No	No	8	8	7
168	R:R:H242	R:R:I313	6.63	No	No	0	8	8
169	R:R:H242	R:R:R316	6.77	No	No	8	8	8
170	R:R:L247	R:R:S243	6.01	No	No	0	5	7
171	R:R:E252	R:R:L244	3.98	No	No	0	7	8
172	R:R:I317	R:R:L245	5.71	Yes	No	2	9	8
173	R:R:R316	R:R:V246	13.08	No	No	8	8	7
174	R:R:H255	R:R:Y258	4.36	No	No	0	4	3
175	R:R:H255	R:R:Y259	7.62	No	Yes	0	4	8
176	R:R:F270	R:R:P302	14.45	No	No	0	5	9
177	R:R:R278	R:R:W274	11	Yes	Yes	0	8	8
178	R:R:I299	R:R:W274	12.92	No	Yes	1	7	8
179	R:R:V275	R:R:W287	4.9	No	Yes	4	6	9
180	R:R:V277	R:R:Y281	3.79	No	No	0	5	3
181	R:R:I295	R:R:V277	7.68	No	No	0	3	5
182	R:R:R278	R:R:T284	3.88	Yes	No	0	8	4
183	R:R:R278	R:R:W287	24.99	Yes	Yes	0	8	9
184	R:R:I295	R:R:R278	3.76	No	Yes	0	3	8
185	R:R:E282	R:R:E291	5.07	No	No	0	5	4
186	R:R:E282	R:R:V292	5.7	No	No	0	5	6
187	R:R:N283	R:R:W287	5.65	No	Yes	4	6	9
188	R:R:R289	R:R:T284	3.88	Yes	No	0	4	4
189	R:R:Q285	R:R:R289	4.67	No	Yes	0	3	4
190	R:R:C286	R:R:E288	4.56	No	Yes	0	9	6
191	L:L:I7	R:R:E288	5.47	No	Yes	0	0	6
192	L:L:S11	R:R:E288	8.62	No	Yes	0	0	6
193	L:L:S11	R:R:R289	7.91	No	Yes	0	0	4
194	L:L:D15	R:R:R289	4.76	No	Yes	0	0	4
195	R:R:N290	R:R:W296	25.99	No	Yes	0	6	6
196	L:L:S8	R:R:N290	7.45	No	No	0	0	6
197	R:R:I295	R:R:V292	7.68	No	No	0	3	6
198	R:R:E362	R:R:K293	5.4	No	No	0	5	5
199	R:R:E363	R:R:K293	5.4	No	No	0	5	5
200	R:R:R300	R:R:W296	11	No	Yes	0	7	6
201	L:L:Y1	R:R:W296	4.82	Yes	Yes	1	0	6
202	R:R:R300	R:R:W297	16.99	No	No	0	7	7
203	R:R:E354	R:R:I307	5.47	Yes	No	1	7	7
204	R:R:F311	R:R:I315	6.28	No	No	0	6	5
205	R:R:F311	R:R:V355	14.42	No	No	0	6	5
206	R:R:F314	R:R:L318	8.53	Yes	No	0	9	7
207	R:R:F314	R:R:L346	7.31	Yes	No	2	9	9
208	R:R:F314	R:R:V347	3.93	Yes	No	2	9	8
209	R:R:F314	R:R:L350	3.65	Yes	No	2	9	9
210	R:R:F314	R:R:V352	17.04	Yes	No	2	9	6
211	R:R:L318	R:R:T343	7.37	No	No	0	7	9
212	R:R:L325	R:R:R338	4.86	No	No	0	7	9
213	R:R:R328	R:R:R331	6.4	No	No	0	6	5
214	R:R:D334	R:R:R331	8.34	No	No	0	6	5
215	R:R:R336	R:R:Y335	6.17	No	No	0	6	5
216	R:R:R338	R:R:R341	7.46	No	No	0	9	9
217	R:R:R338	R:R:S342	3.95	No	No	0	9	9
218	R:R:F345	R:R:R341	10.69	No	No	0	8	9
219	R:R:F345	R:R:L391	10.96	No	No	0	8	7
220	R:R:F345	R:R:I395	3.77	No	No	0	8	5
221	R:R:L346	R:R:L350	6.92	No	No	2	9	9
222	R:R:V347	R:R:V352	11.22	No	No	2	8	6
223	R:R:L387	R:R:P348	4.93	No	No	0	6	9
224	R:R:L349	R:R:Y392	16.41	No	No	0	9	8
225	R:R:E354	R:R:H353	11.08	Yes	Yes	0	7	8
226	R:R:H353	R:R:L380	10.29	Yes	No	0	8	7
227	R:R:H353	R:R:Q384	9.89	Yes	No	0	8	9
228	R:R:E354	R:R:E377	17.76	Yes	Yes	1	7	7
229	R:R:F357	R:R:V356	3.93	Yes	No	0	7	6
230	R:R:F357	R:R:K373	9.93	Yes	No	1	7	7
231	R:R:F357	R:R:F376	8.57	Yes	No	0	7	4
232	R:R:E377	R:R:F357	4.66	Yes	Yes	1	7	7
233	R:R:K373	R:R:V360	4.55	No	No	0	7	4
234	R:R:E362	R:R:R370	12.79	No	No	0	5	5
235	L:L:D9	R:R:R370	11.91	No	No	0	0	5
236	R:R:E377	R:R:K373	9.45	Yes	No	1	7	7
237	R:R:F376	R:R:L380	6.09	No	No	0	4	7
238	L:L:A2	R:R:E377	4.53	No	Yes	0	0	7
239	L:L:F6	R:R:I378	5.02	Yes	No	7	0	8
240	R:R:F379	R:R:L380	3.65	No	No	0	6	7
241	R:R:F379	R:R:F383	8.57	No	No	0	6	6
242	L:L:E3	R:R:S381	7.19	No	No	1	0	5
243	R:R:F386	R:R:V390	6.55	No	No	0	5	5
244	R:R:V388	R:R:Y392	3.79	No	No	0	9	8
245	R:R:C393	R:R:F394	4.19	No	No	0	9	8
246	R:R:N396	R:R:V399	5.91	No	No	0	9	9
247	R:R:E402	R:R:R405	10.47	No	No	0	8	8
248	R:R:H409	R:R:R405	6.77	No	No	0	7	8
249	R:R:R411	R:R:W407	13.99	No	No	0	4	5
250	L:L:E3	L:L:Y1	11.22	No	Yes	1	0	0
251	L:L:G4	L:L:Y1	5.79	No	Yes	0	0	0
252	L:L:M14	L:L:Y10	10.78	No	No	0	0	0
253	L:L:D15	L:L:Q19	6.53	No	No	0	0	0
254	L:L:D21	L:L:N24	5.39	No	No	0	0	0
255	L:L:F22	L:L:W25	4.01	Yes	No	0	0	0
256	L:L:F22	L:L:L26	10.96	Yes	No	3	0	0
257	L:L:Q29	L:L:W25	17.52	No	No	0	0	0
258	R:R:N396	R:R:R169	3.62	No	No	0	9	9
259	R:R:A74	R:R:C103	3.61	No	No	0	7	9
260	R:R:A155	R:R:C393	3.61	No	No	0	9	9
261	R:R:A186	R:R:C226	3.61	No	No	0	6	6
262	R:R:P348	R:R:V347	3.53	No	No	0	9	8
263	R:R:L201	R:R:Y200	3.52	No	No	0	2	4
264	R:R:I298	R:R:W274	3.52	No	Yes	0	8	8
265	R:R:L280	R:R:Y281	3.52	No	No	0	3	3
266	R:R:L325	R:R:Y335	3.52	No	No	0	7	5
267	R:R:P302	R:R:T301	3.5	No	No	0	9	4
268	R:R:E48	R:R:R44	3.49	No	No	0	3	5
269	R:R:A155	R:R:S389	3.42	No	No	0	9	8
270	R:R:A229	R:R:S179	3.42	No	No	0	8	9
271	R:R:I272	R:R:P273	3.39	No	No	0	2	4
272	R:R:A186	R:R:T223	3.36	No	No	0	6	6
273	R:R:G351	R:R:H353	3.18	No	Yes	0	9	8
274	R:R:C226	R:R:L182	3.17	No	No	0	6	7
275	R:R:A184	R:R:L149	3.15	No	No	0	8	6
276	R:R:A215	R:R:L193	3.15	No	No	0	3	5
277	R:R:I174	R:R:S160	3.1	No	No	0	7	3
278	R:R:I395	R:R:V390	3.07	No	No	0	5	5
279	R:R:F383	R:R:G144	3.01	No	No	0	6	8
280	R:R:F270	R:R:G228	3.01	No	No	0	5	5
281	R:R:L321	R:R:S342	3	No	No	0	9	9
282	R:R:L235	R:R:V239	2.98	Yes	No	0	8	7
283	R:R:L339	R:R:T343	2.95	No	No	0	9	9
284	L:L:T5	R:R:L374	2.95	No	No	0	0	6
285	R:R:I158	R:R:I403	2.94	No	No	0	8	5
286	R:R:I313	R:R:I317	2.94	No	Yes	0	8	9
287	L:L:H18	R:R:A32	2.93	Yes	No	0	0	4
288	R:R:A95	R:R:H91	2.93	No	No	0	5	5
289	R:R:I320	R:R:K324	2.91	No	No	0	8	9
290	L:L:D9	L:L:T5	2.89	No	No	0	0	0
291	R:R:I133	R:R:L137	2.85	No	No	0	4	6
292	R:R:I309	R:R:L235	2.85	No	Yes	0	6	8
293	R:R:I276	R:R:L280	2.85	No	No	0	3	3
294	R:R:I317	R:R:L346	2.85	Yes	No	2	9	9
295	R:R:I378	R:R:L374	2.85	No	No	0	8	6
296	R:R:L149	R:R:M181	2.83	No	No	0	6	7
297	R:R:L153	R:R:M181	2.83	No	No	0	3	7
298	R:R:L156	R:R:M181	2.83	No	No	0	6	7
299	R:R:E253	R:R:T168	2.82	No	No	0	5	8
300	R:R:G198	R:R:W209	2.81	No	No	0	3	4
301	L:L:D21	L:L:I17	2.8	No	No	0	0	0
302	R:R:C332	R:R:R333	2.79	No	No	0	6	6
303	R:R:L325	R:R:L339	2.77	No	No	0	7	9
304	R:R:A268	R:R:Y225	2.67	No	No	0	3	8
305	R:R:F270	R:R:V271	2.62	No	No	0	5	6
306	R:R:F311	R:R:V352	2.62	No	No	0	6	6
307	R:R:A212	R:R:W209	2.59	No	No	0	6	4
308	R:R:S148	R:R:Y145	2.54	No	Yes	0	9	7
309	R:R:S243	R:R:Y259	2.54	No	Yes	0	7	8
310	L:L:I12	R:R:R289	2.51	No	Yes	0	0	4
311	R:R:F394	R:R:L154	2.44	No	No	0	8	5
312	R:R:L100	R:R:R81	2.43	Yes	No	0	4	4
313	R:R:L132	R:R:R136	2.43	No	No	0	3	4
314	R:R:L280	R:R:Y279	2.34	No	No	0	3	3
315	R:R:L100	R:R:W112	2.28	Yes	No	0	4	5
316	R:R:H166	R:R:R163	2.26	No	No	0	7	8
317	L:L:Q20	R:R:W90	2.19	No	Yes	0	0	4
318	R:R:G249	R:R:G250	2.11	No	No	0	7	6
319	R:R:G265	R:R:P267	2.03	No	Yes	0	6	9
320	R:R:A75	R:R:P76	1.87	No	No	0	2	4
321	R:R:A266	R:R:P267	1.87	No	Yes	0	4	9
322	R:R:A358	R:R:P359	1.87	No	No	0	6	5
323	R:R:G63	R:R:S64	1.86	No	No	0	4	6
324	R:R:G33	R:R:T31	1.82	No	No	0	5	5
325	R:R:A74	R:R:A80	1.79	No	No	0	7	6
326	R:R:G238	R:R:I313	1.76	No	No	0	9	8
327	R:R:G375	R:R:L137	1.71	No	No	0	5	6
328	R:R:C226	R:R:V222	1.71	No	No	0	6	5
329	R:R:G319	R:R:L322	1.71	No	No	0	8	5
330	R:R:A294	R:R:V292	1.7	No	No	0	3	6
331	R:R:A365	R:R:V360	1.7	No	No	0	6	4
332	R:R:A268	R:R:I272	1.62	No	No	0	3	2
333	R:R:V139	R:R:V143	1.6	No	No	0	3	5
334	L:L:H18	R:R:G202	1.59	Yes	No	0	0	1
335	R:R:T218	R:R:V222	1.59	No	No	0	3	5
336	R:R:G406	R:R:H409	1.59	No	No	0	5	7
337	L:L:A13	R:R:L134	1.58	No	No	0	0	5
338	R:R:A219	R:R:L193	1.58	No	No	0	6	5
339	R:R:A358	R:R:L304	1.58	No	No	0	6	4
340	R:R:I320	R:R:V246	1.54	No	No	0	8	7
341	R:R:L188	R:R:S146	1.5	No	No	0	7	7
342	R:R:L369	R:R:V360	1.49	No	No	0	4	4
343	R:R:L188	R:R:T142	1.47	No	No	0	7	7
344	R:R:I309	R:R:M305	1.46	No	No	0	6	4
345	R:R:D191	R:R:T142	1.45	No	No	0	7	7
346	R:R:P197	R:R:R196	1.44	No	No	0	4	3
347	L:L:I17	R:R:L128	1.43	No	No	0	0	3
348	R:R:Q364	R:R:T361	1.42	No	No	0	5	7
349	R:R:G63	R:R:W71	1.41	No	Yes	0	4	9
350	R:R:E363	R:R:T361	1.41	No	No	0	5	7
351	R:R:A219	R:R:R190	1.38	No	Yes	0	6	6
352	R:R:L322	R:R:L339	1.38	No	No	0	5	9
353	R:R:D129	R:R:L132	1.36	No	No	0	1	3
354	L:L:K16	L:L:Q19	1.36	No	No	0	0	0
355	R:R:E135	R:R:L132	1.33	No	No	0	3	3
356	R:R:R164	R:R:S401	1.32	No	No	0	7	4
357	R:R:A80	R:R:W71	1.3	No	Yes	0	6	9
358	L:L:V23	R:R:Y68	1.26	No	No	0	0	5
359	R:R:M330	R:R:R331	1.24	No	No	0	5	5
360	R:R:Q47	R:R:R43	1.17	No	No	0	3	4
361	R:R:E40	R:R:R44	1.16	No	No	0	3	5
362	R:R:R38	R:R:Y87	1.03	No	Yes	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:W39	7.422	5	3	6
2	R:R:Y42	7.6025	4	3	7
3	R:R:F65	5.5425	4	0	7
4	R:R:W71	4.87286	7	0	9
5	R:R:P85	7.01	4	3	8
6	R:R:Y87	7.64	4	3	4
7	R:R:W90	8.54333	6	6	4
8	R:R:L100	4.3175	4	0	4
9	R:R:Y141	5.09	4	7	7
10	R:R:Y145	5.49167	6	0	7
11	R:R:F180	10.435	4	0	8
12	R:R:R183	6.91	6	1	8
13	R:R:R190	7.795	4	0	6
14	R:R:Q224	6.062	5	1	6
15	R:R:Y231	6.665	4	1	8
16	R:R:W233	10.5925	4	0	9
17	R:R:L235	5.0175	4	0	8
18	R:R:E237	8.785	4	0	9
19	R:R:Y240	6.365	4	0	8
20	R:R:Y259	4.54	5	0	8
21	R:R:P267	5.152	5	0	9
22	R:R:W274	8.5025	4	1	8
23	R:R:R278	10.9075	4	0	8
24	R:R:W287	9.248	5	4	9
25	R:R:E288	5.6575	4	0	6
26	R:R:R289	5.03333	6	0	4
27	R:R:W296	11.8225	4	1	6
28	R:R:F314	8.092	5	2	9
29	R:R:I317	3.945	4	2	9
30	R:R:H353	8.61	4	0	8
31	R:R:E354	9.98	4	1	7
32	R:R:F357	6.7725	4	1	7
33	R:R:E377	9.1	4	1	7
34	L:L:Y1	8.694	5	1	0
35	L:L:F6	6.3625	4	7	0
36	L:L:H18	3.635	4	0	0
37	L:L:F22	8.11	5	3	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:D15	L:L:Q19	66.0423	6.53	No	No	0	0	0
2	L:L:D15	R:R:R289	66.7357	4.76	No	Yes	0	0	4
3	L:L:Q19	R:R:L35	64.6503	3.99	No	No	0	0	5
4	L:L:F22	R:R:L35	63.95	7.31	Yes	No	0	0	5
5	L:L:F22	R:R:W39	54.6662	10.02	Yes	Yes	3	0	6
6	R:R:F65	R:R:W39	10.9959	5.01	Yes	Yes	0	7	6
7	R:R:W39	R:R:Y87	42.3001	8.68	Yes	Yes	3	6	4
8	R:R:P85	R:R:Y87	36.0883	6.95	Yes	Yes	3	8	4
9	R:R:V69	R:R:W71	21.9222	4.9	No	Yes	0	5	9
10	R:R:P85	R:R:V69	22.713	10.6	Yes	No	0	8	5
11	R:R:D66	R:R:W71	13.1117	7.82	No	Yes	0	9	9
12	R:R:D66	R:R:R113	11.4761	5.96	No	No	5	9	6
13	R:R:L88	R:R:W90	13.1813	6.83	No	Yes	0	5	4
14	R:R:L88	R:R:P85	13.9913	4.93	No	Yes	0	5	8
15	L:L:L27	R:R:R113	10.7131	3.64	No	No	0	0	6
16	R:R:Q138	R:R:Y141	10.547	4.51	No	Yes	0	5	7
17	R:R:Y141	R:R:Y145	20.1265	3.97	Yes	Yes	0	7	7
18	R:R:R183	R:R:Y145	24.7088	5.14	Yes	Yes	0	8	7
19	R:R:R183	R:R:V227	50.974	9.15	Yes	No	0	8	6
20	L:L:Y1	R:R:V227	50.7365	12.62	Yes	No	0	0	6
21	L:L:Y1	R:R:Q224	96.7793	9.02	Yes	Yes	1	0	6
22	R:R:Q224	R:R:W274	83.203	6.57	Yes	Yes	1	6	8
23	R:R:R278	R:R:W274	82.018	11	Yes	Yes	0	8	8
24	R:R:R278	R:R:T284	71.5781	3.88	Yes	No	0	8	4
25	R:R:R289	R:R:T284	70.9204	3.88	Yes	No	0	4	4
26	L:L:E3	R:R:R183	50.9731	8.14	No	Yes	1	0	8
27	L:L:E3	L:L:Y1	50.8591	11.22	No	Yes	1	0	0
28	R:R:N230	R:R:R183	98.0521	9.64	No	Yes	0	9	8
29	R:R:F180	R:R:N230	49.3279	20.54	Yes	No	0	8	9
30	R:R:F180	R:R:L176	51.8692	7.31	Yes	No	0	8	9
31	R:R:E237	R:R:L176	100	5.3	Yes	No	0	9	9
32	R:R:E237	R:R:H173	41.8573	11.08	Yes	No	0	9	9
33	R:R:H173	R:R:Y392	33.0364	7.62	No	No	0	9	8
34	R:R:V388	R:R:Y392	63.8177	3.79	No	No	0	9	8
35	R:R:F177	R:R:V388	62.5554	3.93	No	No	0	9	9
36	R:R:F177	R:R:L152	61.2912	4.87	No	No	0	9	9
37	R:R:L152	R:R:S389	60.0254	6.01	No	No	0	9	8
38	R:R:S389	R:R:T151	51.1419	4.8	No	No	0	8	7
39	R:R:F386	R:R:T151	49.8621	7.78	No	No	0	5	7
40	R:R:L234	R:R:N230	48.7485	4.12	No	No	0	9	9
41	R:R:L176	R:R:L234	48.5989	4.15	No	No	0	9	9
42	R:R:E237	R:R:L349	32.6649	11.93	Yes	No	0	9	9
43	R:R:L349	R:R:Y392	32.0655	16.41	No	No	0	9	8
44	R:R:H173	R:R:R169	10.192	4.51	No	No	0	9	9
45	R:R:E237	R:R:I172	35.9831	6.83	Yes	No	0	9	9
46	R:R:I172	R:R:Y240	32.6553	3.63	No	Yes	0	9	8
47	R:R:Y240	R:R:Y259	29.2841	4.96	Yes	Yes	0	8	8
48	R:R:V236	R:R:Y259	21.7142	3.79	No	Yes	0	8	8
49	R:R:V236	R:R:W233	20.3153	4.9	No	Yes	0	8	9
50	R:R:Q220	R:R:Q224	13.4093	5.12	No	Yes	0	5	6
51	R:R:Q220	R:R:R190	12.6785	8.18	No	Yes	0	5	6
52	R:R:W233	R:R:W264	10.9306	16.87	Yes	No	0	9	9
53	R:R:F386	R:R:V390	47.2974	6.55	No	No	0	5	5
54	R:R:I395	R:R:V390	46.0124	3.07	No	No	0	5	5
55	R:R:F345	R:R:I395	44.7239	3.77	No	No	0	8	5
56	R:R:F345	R:R:R341	42.1739	10.69	No	No	0	8	9
57	R:R:R338	R:R:R341	40.882	7.46	No	No	0	9	9
58	R:R:L325	R:R:R338	37.0262	4.86	No	No	0	7	9
59	R:R:L325	R:R:L339	33.1242	2.77	No	No	0	7	9
60	R:R:L339	R:R:T343	29.2067	2.95	No	No	0	9	9
61	R:R:L318	R:R:T343	27.8973	7.37	No	No	0	7	9
62	R:R:F314	R:R:L318	26.5862	8.53	Yes	No	0	9	7
63	R:R:F314	R:R:L346	14.6986	7.31	Yes	No	2	9	9
64	R:R:I317	R:R:L346	13.3797	2.85	Yes	No	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:R289	R:R:T31	6.47	0	Yes	No	4	5	1	2
L:L:Q19	R:R:L35	3.99	0	No	No	0	5	0	1
L:L:F22	R:R:L35	7.31	3	Yes	No	0	5	0	1
L:L:H18	R:R:Y36	5.44	0	Yes	No	0	3	0	1
L:L:F22	R:R:Y36	8.25	3	Yes	No	0	3	0	1
R:R:F65	R:R:W39	5.01	0	Yes	Yes	7	6	2	1
R:R:W39	R:R:Y87	8.68	3	Yes	Yes	6	4	1	2
R:R:Q204	R:R:W39	6.57	0	No	Yes	4	6	2	1
L:L:F22	R:R:W39	10.02	3	Yes	Yes	0	6	0	1
L:L:L26	R:R:W39	6.83	3	No	Yes	0	6	0	1
R:R:D66	R:R:W71	7.82	5	No	Yes	9	9	1	2
R:R:D66	R:R:R113	5.96	5	No	No	9	6	1	1
L:L:K30	R:R:D66	5.53	5	No	No	0	9	0	1
L:L:Q29	R:R:M67	17.67	0	No	No	0	3	0	1
R:R:C118	R:R:Y68	5.38	0	No	No	9	5	2	1
R:R:R101	R:R:W71	6	0	No	Yes	8	9	1	2
R:R:L88	R:R:W90	6.83	0	No	Yes	5	4	2	1
R:R:P89	R:R:W90	9.46	0	No	Yes	3	4	2	1
R:R:V94	R:R:W90	6.13	0	No	Yes	3	4	2	1
R:R:N120	R:R:W90	22.6	6	No	Yes	3	4	2	1
R:R:P121	R:R:W90	4.05	6	No	Yes	2	4	2	1
L:L:K30	R:R:R101	8.66	5	No	No	0	8	0	1
L:L:L27	R:R:R113	3.64	0	No	No	0	6	0	1
L:L:K30	R:R:R113	19.8	5	No	No	0	6	0	1
R:R:E119	R:R:H115	3.69	0	No	No	1	7	2	1
L:L:L27	R:R:H115	10.29	0	No	No	0	7	0	1
R:R:N120	R:R:P121	6.52	6	No	No	3	2	2	2
R:R:F127	R:R:N124	4.83	0	No	No	2	1	2	1
L:L:Q20	R:R:N124	11.88	0	No	No	0	1	0	1
R:R:E135	R:R:R131	8.14	0	No	No	3	3	2	1
L:L:M14	R:R:R131	9.93	0	No	No	0	3	0	1
L:L:I17	R:R:R131	3.76	0	No	No	0	3	0	1
L:L:F6	R:R:L134	6.09	7	Yes	No	0	5	0	1
L:L:Y10	R:R:L134	7.03	0	No	No	0	5	0	1
L:L:F6	R:R:L137	6.09	7	Yes	No	0	6	0	1
R:R:Q138	R:R:Y141	4.51	0	No	Yes	5	7	1	1
R:R:D191	R:R:Q138	9.14	0	No	No	7	5	2	1
L:L:Y10	R:R:Q138	4.51	0	No	No	0	5	0	1
R:R:Y141	R:R:Y145	3.97	7	Yes	Yes	7	7	1	2
R:R:I378	R:R:Y141	3.63	7	No	Yes	8	7	1	1
L:L:F6	R:R:Y141	8.25	7	Yes	Yes	0	7	0	1
R:R:R183	R:R:Y145	5.14	1	Yes	Yes	8	7	1	2
R:R:R183	R:R:V227	9.15	1	Yes	No	8	6	1	1
R:R:N230	R:R:R183	9.64	0	No	Yes	9	8	2	1
R:R:R183	R:R:Y231	4.12	1	Yes	Yes	8	8	1	2
R:R:R183	R:R:S381	5.27	1	Yes	No	8	5	1	1
L:L:E3	R:R:R183	8.14	1	No	Yes	0	8	0	1
R:R:Q220	R:R:R190	8.18	0	No	Yes	5	6	2	1
R:R:R190	R:R:T223	10.35	0	Yes	No	6	6	1	2
L:L:I7	R:R:R190	11.27	0	No	Yes	0	6	0	1
R:R:E288	R:R:L194	3.98	0	Yes	No	6	7	1	2
R:R:G198	R:R:P199	4.06	0	No	No	3	3	2	1
L:L:H18	R:R:P199	4.58	0	Yes	No	0	3	0	1
R:R:Q220	R:R:Q224	5.12	0	No	Yes	5	6	2	1
R:R:Q224	R:R:W274	6.57	1	Yes	Yes	6	8	1	2
R:R:Q224	R:R:W296	5.48	1	Yes	Yes	6	6	1	1
R:R:I299	R:R:Q224	4.12	1	No	Yes	7	6	2	1
L:L:Y1	R:R:Q224	9.02	1	Yes	Yes	0	6	0	1
L:L:Y1	R:R:V227	12.62	1	Yes	No	0	6	0	1
R:R:E354	R:R:Y231	5.61	1	Yes	Yes	7	8	2	2
R:R:I299	R:R:W274	12.92	1	No	Yes	7	8	2	2
R:R:R289	R:R:T284	3.88	0	Yes	No	4	4	1	2
R:R:Q285	R:R:R289	4.67	0	No	Yes	3	4	2	1
R:R:C286	R:R:E288	4.56	0	No	Yes	9	6	2	1
L:L:I7	R:R:E288	5.47	0	No	Yes	0	6	0	1
L:L:S11	R:R:E288	8.62	0	No	Yes	0	6	0	1
L:L:S11	R:R:R289	7.91	0	No	Yes	0	4	0	1
L:L:D15	R:R:R289	4.76	0	No	Yes	0	4	0	1
R:R:N290	R:R:W296	25.99	0	No	Yes	6	6	1	1
L:L:S8	R:R:N290	7.45	0	No	No	0	6	0	1
R:R:R300	R:R:W296	11	0	No	Yes	7	6	2	1
L:L:Y1	R:R:W296	4.82	1	Yes	Yes	0	6	0	1
R:R:E354	R:R:E377	17.76	1	Yes	Yes	7	7	2	1
R:R:F357	R:R:K373	9.93	1	Yes	No	7	7	2	2
R:R:E377	R:R:F357	4.66	1	Yes	Yes	7	7	1	2
R:R:E362	R:R:R370	12.79	0	No	No	5	5	2	1
L:L:D9	R:R:R370	11.91	0	No	No	0	5	0	1
R:R:E377	R:R:K373	9.45	1	Yes	No	7	7	1	2
L:L:A2	R:R:E377	4.53	0	No	Yes	0	7	0	1
L:L:F6	R:R:I378	5.02	7	Yes	No	0	8	0	1
L:L:E3	R:R:S381	7.19	1	No	No	0	5	0	1
L:L:T5	R:R:L374	2.95	0	No	No	0	6	0	1
L:L:H18	R:R:A32	2.93	0	Yes	No	0	4	0	1
R:R:I133	R:R:L137	2.85	0	No	No	4	6	2	1
R:R:I378	R:R:L374	2.85	7	No	No	8	6	1	1
L:L:I12	R:R:R289	2.51	0	No	Yes	0	4	0	1
L:L:Q20	R:R:W90	2.19	0	No	Yes	0	4	0	1
R:R:G375	R:R:L137	1.71	0	No	No	5	6	2	1
L:L:H18	R:R:G202	1.59	0	Yes	No	0	1	0	1
L:L:A13	R:R:L134	1.58	0	No	No	0	5	0	1
L:L:I17	R:R:L128	1.43	0	No	No	0	3	0	1
R:R:A219	R:R:R190	1.38	0	No	Yes	6	6	2	1
L:L:V23	R:R:Y68	1.26	0	No	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7DTY_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.63
Number of Linked Nodes	345
Number of Links	362
Number of Hubs	37
Number of Links mediated by Hubs	145
Number of Communities	8
Number of Nodes involved in Communities	45
Number of Links involved in Communities	53

Path Summary
Number Of Nodes in MetaPath	65
Number Of Links MetaPath	64
Number of Shortest Paths	159753
Length Of Smallest Path	3
Average Path Length	24.5968
Length of Longest Path	58
Minimum Path Strength	1.345
Average Path Strength	6.92386
Maximum Path Strength	18.63
Minimum Path Correlation	0.7
Average Path Correlation	0.955698
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.32558
Average % Of Corr. Nodes	47.0511
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.3196
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• peptide hormone receptor binding • protein binding • binding • corticotropin-releasing hormone receptor binding • signaling receptor binding • G protein-coupled receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • mu-type opioid receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • adrenergic receptor binding • D1 dopamine receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • ionotropic glutamate receptor binding • glutamate receptor binding • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • molecular function regulator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • insulin-like growth factor receptor binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • intracellular anatomical structure • cytoplasm • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • signaling receptor binding • G protein-coupled receptor binding • gastric inhibitory polypeptide receptor binding • hormone activity • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • glucagon receptor binding • pancreas development • endocrine system development • endocrine pancreas development • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adult locomotory behavior • behavior • adult behavior • locomotory behavior • exploration behavior • oxoacid metabolic process • ketone metabolic process • regulation of lipid metabolic process • lipid biosynthetic process • organic acid biosynthetic process • organic acid metabolic process • carboxylic acid biosynthetic process • regulation of primary metabolic process • regulation of small molecule metabolic process • small molecule metabolic process • regulation of biosynthetic process • fatty acid metabolic process • monocarboxylic acid biosynthetic process • small molecule biosynthetic process • carboxylic acid metabolic process • primary metabolic process • fatty acid biosynthetic process • regulation of ketone metabolic process • biosynthetic process • regulation of fatty acid biosynthetic process • regulation of fatty acid metabolic process • metabolic process • regulation of lipid biosynthetic process • monocarboxylic acid metabolic process • regulation of metabolic process • lipid metabolic process • sensory perception of pain • learning or memory • cognition • memory • positive regulation of cell communication • positive regulation of establishment of protein localization • positive regulation of insulin secretion • positive regulation of peptide hormone secretion • positive regulation of protein localization • positive regulation of biological process • positive regulation of secretion by cell • positive regulation of protein transport • positive regulation of hormone secretion • positive regulation of secretion • positive regulation of cellular process • positive regulation of peptide secretion • positive regulation of protein secretion • positive regulation of transport • positive regulation of signaling • response to hexose • response to monosaccharide • response to carbohydrate • response to glucose • gastric inhibitory peptide signaling pathway • response to nutrient levels • response to starvation • membrane-enclosed lumen • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle lumen • endoplasmic reticulum lumen • intracellular organelle • organelle lumen • endoplasmic reticulum • extracellular region • vesicle lumen • intracellular vesicle • cytoplasmic vesicle lumen • secretory granule lumen • cytoplasmic vesicle • secretory granule • secretory vesicle • vesicle • extracellular space • amide binding • glucagon family peptide binding • peptide hormone binding • hormone binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • gastric inhibitory peptide receptor activity • peptide receptor activity • G protein-coupled peptide receptor activity • response to wounding • response to axon injury • response to metal ion • response to calcium ion • negative adaptation of signaling pathway • negative regulation of signaling • negative regulation of biological process • desensitization of G protein-coupled receptor signaling pathway • regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • negative regulation of response to stimulus • negative regulation of signal transduction • regulation of response to stimulus • adaptation of signaling pathway • generation of precursor metabolites and energy • cell surface receptor signaling pathway • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to fatty acid • response to nutrient
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • FnI-like domain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • FnI-like domain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P48546
Sequence	>7DTY_nogp_Chain_R T A G E L Y Q R W E R Y R R E C Q E T A C N G S F D M Y V C W D Y A A P N A T A R A S C P W Y L P W H H H V A A G F V L R Q C W R D H T Q C E N P E K N E A F L D Q R L I L E R L Q V M Y T V G Y S L S L A T L L L A L L I L S L F R R L H C T R N Y I H I N L F T S F M L R A A A I L S R D R L L P R P G P Y L G D Q A L A L W N Q A L A A C R T A Q I V T Q Y C V G A N Y T W L L V E G V Y L H S L L V L V G G S E E G H F R Y Y L L L G W G A P A L F V I P W V I V R Y L Y E N T Q C W E R N E V K A I W W I I R T P I L M T I L I N F L I F I R I L G I L L S K L R T R Q M R C R D Y R L R L A R S T L F L V P L L G V H E V V F A P V T E E Q A R G A L R F A K L G F E I F L S S F Q G F L V S V L Y C F I N K E V Q S E I R R G W H H C R L R R S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7RBT	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	LSN3556672	chim(NtGi1-Gs)/β1/γ2	3.08	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RBT (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	LSN3556672		3.08	2022-04-13	doi.org/10.1073/pnas.2116506119
	8WA3	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	2.86	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		2.86	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	7FIN	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-	Gs/β1/γ2	3.1	2022-02-23	doi.org/10.1038/s41467-022-28683-0
	7FIN (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-		3.1	2022-02-23	doi.org/10.1038/s41467-022-28683-0
	7FIY	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VAB	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VAB (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-		3.2	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7RA3	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	chim(NtGi1-Gs)/β1/γ2	3.24	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		3.24	2022-04-13	doi.org/10.1073/pnas.2116506119
	8ITL	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.23	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITL (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.23	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITM	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.13	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITM (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.13	2023-10-18	doi.org/10.1073/pnas.2306145120
	7DTY	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	Gs/β1/γ2	2.98	2021-08-04	doi.org/10.7554/eLife.68719
	7DTY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		2.98	2021-08-04	doi.org/10.7554/eLife.68719
	8YW4	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ2	3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW4 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-		3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0

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