psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E34	R:R:T31	7.06	No	No	0	5	5
2	R:R:R289	R:R:T31	6.47	Yes	No	0	4	5
3	L:L:Q19	R:R:L35	3.99	No	No	0	0	5
4	L:L:F22	R:R:L35	7.31	Yes	No	0	0	5
5	L:L:H18	R:R:Y36	5.44	Yes	No	0	0	3
6	L:L:F22	R:R:Y36	8.25	Yes	No	0	0	3
7	R:R:F65	R:R:W39	5.01	Yes	Yes	0	7	6
8	R:R:W39	R:R:Y87	8.68	Yes	Yes	3	6	4
9	R:R:Q204	R:R:W39	6.57	No	Yes	0	4	6
10	L:L:F22	R:R:W39	10.02	Yes	Yes	3	0	6
11	L:L:L26	R:R:W39	6.83	No	Yes	3	0	6
12	R:R:E40	R:R:R43	10.47	No	No	0	3	4
13	R:R:E45	R:R:R41	4.65	No	No	0	4	5
14	R:R:F65	R:R:Y42	5.16	Yes	Yes	0	7	7
15	R:R:P85	R:R:Y42	5.56	Yes	Yes	3	8	7
16	R:R:W86	R:R:Y42	5.79	No	Yes	0	1	7
17	R:R:Y42	R:R:Y87	13.9	Yes	Yes	3	7	4
18	R:R:F65	R:R:R43	6.41	Yes	No	0	7	4
19	R:R:E45	R:R:W86	7.63	No	No	0	4	1
20	R:R:C46	R:R:F65	5.59	No	Yes	0	8	7
21	R:R:C46	R:R:C70	7.28	No	No	0	8	9
22	R:R:C103	R:R:C61	7.28	No	No	0	9	9
23	R:R:N62	R:R:Y73	8.14	No	No	0	4	4
24	R:R:D66	R:R:W71	7.82	No	Yes	0	9	9
25	R:R:D66	R:R:R113	5.96	No	No	5	9	6
26	L:L:K30	R:R:D66	5.53	No	No	5	0	9
27	L:L:Q29	R:R:M67	17.67	No	No	0	0	3
28	R:R:C118	R:R:Y68	5.38	No	No	0	9	5
29	R:R:V69	R:R:W71	4.9	No	Yes	0	5	9
30	R:R:P85	R:R:V69	10.6	Yes	No	0	8	5
31	R:R:A82	R:R:W71	7.78	No	Yes	0	5	9
32	R:R:V99	R:R:W71	4.9	No	Yes	0	7	9
33	R:R:R101	R:R:W71	6	No	Yes	0	8	9
34	R:R:L100	R:R:T79	4.42	Yes	No	0	4	5
35	R:R:F98	R:R:R81	5.34	No	No	0	3	4
36	R:R:C84	R:R:V94	5.12	No	No	0	9	3
37	R:R:C118	R:R:C84	7.28	No	No	0	9	9
38	R:R:P85	R:R:Y87	6.95	Yes	Yes	3	8	4
39	R:R:L88	R:R:P85	4.93	No	Yes	0	5	8
40	R:R:H91	R:R:W86	5.29	No	No	0	5	1
41	R:R:L88	R:R:W90	6.83	No	Yes	0	5	4
42	R:R:P89	R:R:W90	9.46	No	Yes	0	3	4
43	R:R:V94	R:R:W90	6.13	No	Yes	0	3	4
44	R:R:N120	R:R:W90	22.6	No	Yes	6	3	4
45	R:R:P121	R:R:W90	4.05	No	Yes	6	2	4
46	R:R:H93	R:R:P121	4.58	No	No	0	4	2
47	R:R:G97	R:R:Q117	4.93	No	No	0	6	4
48	R:R:F98	R:R:Q117	4.68	No	No	0	3	4
49	R:R:D114	R:R:L100	8.14	No	Yes	0	8	4
50	L:L:K30	R:R:R101	8.66	No	No	0	0	8
51	R:R:Q102	R:R:W112	14.24	No	No	0	4	5
52	L:L:L27	R:R:R113	3.64	No	No	0	0	6
53	L:L:K30	R:R:R113	19.8	No	No	5	0	6
54	R:R:D114	R:R:T116	5.78	No	No	0	8	6
55	R:R:E119	R:R:H115	3.69	No	No	0	1	7
56	L:L:L27	R:R:H115	10.29	No	No	0	0	7
57	R:R:E119	R:R:T116	8.47	No	No	0	1	6
58	R:R:N120	R:R:P121	6.52	No	No	6	3	2
59	R:R:E122	R:R:N120	11.83	No	No	0	2	3
60	R:R:E125	R:R:K123	12.15	No	No	0	3	3
61	R:R:F127	R:R:N124	4.83	No	No	0	2	1
62	L:L:Q20	R:R:N124	11.88	No	No	0	0	1
63	R:R:F127	R:R:Q130	4.68	No	No	0	2	3
64	R:R:F371	R:R:Q130	8.2	No	No	0	4	3
65	R:R:E135	R:R:R131	8.14	No	No	0	3	3
66	L:L:M14	R:R:R131	9.93	No	No	0	0	3
67	L:L:I17	R:R:R131	3.76	No	No	0	0	3
68	L:L:F6	R:R:L134	6.09	Yes	No	0	0	5
69	L:L:Y10	R:R:L134	7.03	No	No	0	0	5
70	L:L:F6	R:R:L137	6.09	Yes	No	0	0	6
71	R:R:Q138	R:R:Y141	4.51	No	Yes	0	5	7
72	R:R:D191	R:R:Q138	9.14	No	No	0	7	5
73	L:L:Y10	R:R:Q138	4.51	No	No	0	0	5
74	R:R:F379	R:R:M140	3.73	No	No	0	6	6
75	R:R:Y141	R:R:Y145	3.97	Yes	Yes	0	7	7
76	R:R:I378	R:R:Y141	3.63	No	Yes	7	8	7
77	L:L:F6	R:R:Y141	8.25	Yes	Yes	7	0	7
78	R:R:R183	R:R:Y145	5.14	Yes	Yes	0	8	7
79	R:R:A184	R:R:Y145	4	No	Yes	0	8	7
80	R:R:I187	R:R:Y145	9.67	No	Yes	0	7	7
81	R:R:S382	R:R:Y145	7.63	No	Yes	0	9	7
82	R:R:F386	R:R:L147	6.09	No	No	0	5	5
83	R:R:F386	R:R:T151	7.78	No	No	0	5	7
84	R:R:S389	R:R:T151	4.8	No	No	0	8	7
85	R:R:F177	R:R:L152	4.87	No	No	0	9	9
86	R:R:L152	R:R:S389	6.01	No	No	0	9	8
87	R:R:I174	R:R:L156	4.28	No	No	0	7	6
88	R:R:L156	R:R:T178	4.42	No	No	0	6	3
89	R:R:C393	R:R:I158	4.91	No	No	0	9	8
90	R:R:L159	R:R:N170	4.12	No	No	0	8	9
91	R:R:I174	R:R:L159	5.71	No	No	0	7	8
92	R:R:F162	R:R:L165	6.09	No	No	0	7	9
93	R:R:E402	R:R:F162	17.49	No	No	0	8	7
94	R:R:E398	R:R:R164	11.63	No	No	0	9	7
95	R:R:E402	R:R:R164	19.77	No	No	0	8	7
96	R:R:E398	R:R:L165	3.98	No	No	0	9	9
97	R:R:L165	R:R:V399	7.45	No	No	0	9	9
98	R:R:H166	R:R:Y171	9.8	No	No	0	7	6
99	R:R:C167	R:R:N170	4.72	No	No	0	8	9
100	R:R:T168	R:R:Y240	7.49	No	Yes	0	8	8
101	R:R:N170	R:R:R169	12.05	No	No	0	9	9
102	R:R:H173	R:R:R169	4.51	No	No	0	9	9
103	R:R:F256	R:R:Y171	4.13	No	No	0	5	6
104	R:R:E237	R:R:I172	6.83	Yes	No	0	9	9
105	R:R:I172	R:R:Y240	3.63	No	Yes	0	9	8
106	R:R:F256	R:R:I172	3.77	No	No	0	5	9
107	R:R:E237	R:R:H173	11.08	Yes	No	0	9	9
108	R:R:H173	R:R:Y392	7.62	No	No	0	9	8
109	R:R:N175	R:R:W233	13.56	No	Yes	0	9	9
110	R:R:L260	R:R:N175	4.12	No	No	0	6	9
111	R:R:F180	R:R:L176	7.31	Yes	No	0	8	9
112	R:R:L176	R:R:L234	4.15	No	No	0	9	9
113	R:R:E237	R:R:L176	5.3	Yes	No	0	9	9
114	R:R:F177	R:R:V388	3.93	No	No	0	9	9
115	R:R:F180	R:R:N230	20.54	Yes	No	0	8	9
116	R:R:F180	R:R:Q384	9.37	Yes	No	0	8	9
117	R:R:F180	R:R:G385	4.52	Yes	No	0	8	9
118	R:R:R183	R:R:V227	9.15	Yes	No	0	8	6
119	R:R:N230	R:R:R183	9.64	No	Yes	0	9	8
120	R:R:R183	R:R:Y231	4.12	Yes	Yes	1	8	8
121	R:R:R183	R:R:S381	5.27	Yes	No	1	8	5
122	L:L:E3	R:R:R183	8.14	No	Yes	1	0	8
123	R:R:Q220	R:R:R190	8.18	No	Yes	0	5	6
124	R:R:R190	R:R:T223	10.35	Yes	No	0	6	6
125	L:L:I7	R:R:R190	11.27	No	Yes	0	0	6
126	R:R:D191	R:R:R196	4.76	No	No	0	7	3
127	R:R:L194	R:R:P195	4.93	No	No	0	7	3
128	R:R:E288	R:R:L194	3.98	Yes	No	0	6	7
129	R:R:G198	R:R:P199	4.06	No	No	0	3	3
130	L:L:H18	R:R:P199	4.58	Yes	No	0	0	3
131	R:R:D203	R:R:L201	5.43	No	No	0	3	2
132	R:R:L213	R:R:Q285	3.99	No	No	0	4	3
133	R:R:C216	R:R:C286	7.28	No	No	0	9	9
134	R:R:N283	R:R:R217	10.85	No	No	4	6	8
135	R:R:R217	R:R:W287	6	No	Yes	4	8	9
136	R:R:Q220	R:R:Q224	5.12	No	Yes	0	5	6
137	R:R:I221	R:R:V275	6.14	No	No	4	5	6
138	R:R:I221	R:R:W287	4.7	No	Yes	4	5	9
139	R:R:Q224	R:R:W274	6.57	Yes	Yes	1	6	8
140	R:R:Q224	R:R:W296	5.48	Yes	Yes	1	6	6
141	R:R:I299	R:R:Q224	4.12	No	Yes	1	7	6
142	L:L:Y1	R:R:Q224	9.02	Yes	Yes	1	0	6
143	R:R:W264	R:R:Y225	8.68	No	No	0	9	8
144	R:R:P267	R:R:Y225	5.56	Yes	No	0	9	8
145	L:L:Y1	R:R:V227	12.62	Yes	No	0	0	6
146	R:R:G228	R:R:P267	4.06	No	Yes	0	5	9
147	R:R:A229	R:R:W264	3.89	No	No	0	8	9
148	R:R:L234	R:R:N230	4.12	No	No	0	9	9
149	R:R:I303	R:R:Y231	12.09	No	Yes	0	7	8
150	R:R:I307	R:R:Y231	4.84	No	Yes	1	7	8
151	R:R:E354	R:R:Y231	5.61	Yes	Yes	1	7	8
152	R:R:G263	R:R:T232	3.64	No	No	0	9	6
153	R:R:P267	R:R:T232	12.24	Yes	No	0	9	6
154	R:R:V236	R:R:W233	4.9	No	Yes	0	8	9
155	R:R:G263	R:R:W233	7.04	No	Yes	0	9	9
156	R:R:W233	R:R:W264	16.87	Yes	No	0	9	9
157	R:R:L235	R:R:T306	7.37	Yes	No	0	8	7
158	R:R:L235	R:R:N310	6.87	Yes	No	0	8	9
159	R:R:V236	R:R:Y259	3.79	No	Yes	0	8	8
160	R:R:L262	R:R:V236	4.47	No	No	0	6	8
161	R:R:E237	R:R:L349	11.93	Yes	No	0	9	9
162	R:R:V239	R:R:Y259	3.79	No	Yes	0	7	8
163	R:R:L244	R:R:Y240	9.38	No	Yes	0	8	8
164	R:R:Y240	R:R:Y259	4.96	Yes	Yes	0	8	8
165	R:R:L241	R:R:L245	4.15	No	No	2	9	8
166	R:R:I317	R:R:L241	4.28	Yes	No	2	9	9
167	R:R:H242	R:R:V246	12.45	No	No	8	8	7
168	R:R:H242	R:R:I313	6.63	No	No	0	8	8
169	R:R:H242	R:R:R316	6.77	No	No	8	8	8
170	R:R:L247	R:R:S243	6.01	No	No	0	5	7
171	R:R:E252	R:R:L244	3.98	No	No	0	7	8
172	R:R:I317	R:R:L245	5.71	Yes	No	2	9	8
173	R:R:R316	R:R:V246	13.08	No	No	8	8	7
174	R:R:H255	R:R:Y258	4.36	No	No	0	4	3
175	R:R:H255	R:R:Y259	7.62	No	Yes	0	4	8
176	R:R:F270	R:R:P302	14.45	No	No	0	5	9
177	R:R:R278	R:R:W274	11	Yes	Yes	0	8	8
178	R:R:I299	R:R:W274	12.92	No	Yes	1	7	8
179	R:R:V275	R:R:W287	4.9	No	Yes	4	6	9
180	R:R:V277	R:R:Y281	3.79	No	No	0	5	3
181	R:R:I295	R:R:V277	7.68	No	No	0	3	5
182	R:R:R278	R:R:T284	3.88	Yes	No	0	8	4
183	R:R:R278	R:R:W287	24.99	Yes	Yes	0	8	9
184	R:R:I295	R:R:R278	3.76	No	Yes	0	3	8
185	R:R:E282	R:R:E291	5.07	No	No	0	5	4
186	R:R:E282	R:R:V292	5.7	No	No	0	5	6
187	R:R:N283	R:R:W287	5.65	No	Yes	4	6	9
188	R:R:R289	R:R:T284	3.88	Yes	No	0	4	4
189	R:R:Q285	R:R:R289	4.67	No	Yes	0	3	4
190	R:R:C286	R:R:E288	4.56	No	Yes	0	9	6
191	L:L:I7	R:R:E288	5.47	No	Yes	0	0	6
192	L:L:S11	R:R:E288	8.62	No	Yes	0	0	6
193	L:L:S11	R:R:R289	7.91	No	Yes	0	0	4
194	L:L:D15	R:R:R289	4.76	No	Yes	0	0	4
195	R:R:N290	R:R:W296	25.99	No	Yes	0	6	6
196	L:L:S8	R:R:N290	7.45	No	No	0	0	6
197	R:R:I295	R:R:V292	7.68	No	No	0	3	6
198	R:R:E362	R:R:K293	5.4	No	No	0	5	5
199	R:R:E363	R:R:K293	5.4	No	No	0	5	5
200	R:R:R300	R:R:W296	11	No	Yes	0	7	6
201	L:L:Y1	R:R:W296	4.82	Yes	Yes	1	0	6
202	R:R:R300	R:R:W297	16.99	No	No	0	7	7
203	R:R:E354	R:R:I307	5.47	Yes	No	1	7	7
204	R:R:F311	R:R:I315	6.28	No	No	0	6	5
205	R:R:F311	R:R:V355	14.42	No	No	0	6	5
206	R:R:F314	R:R:L318	8.53	Yes	No	0	9	7
207	R:R:F314	R:R:L346	7.31	Yes	No	2	9	9
208	R:R:F314	R:R:V347	3.93	Yes	No	2	9	8
209	R:R:F314	R:R:L350	3.65	Yes	No	2	9	9
210	R:R:F314	R:R:V352	17.04	Yes	No	2	9	6
211	R:R:L318	R:R:T343	7.37	No	No	0	7	9
212	R:R:L325	R:R:R338	4.86	No	No	0	7	9
213	R:R:R328	R:R:R331	6.4	No	No	0	6	5
214	R:R:D334	R:R:R331	8.34	No	No	0	6	5
215	R:R:R336	R:R:Y335	6.17	No	No	0	6	5
216	R:R:R338	R:R:R341	7.46	No	No	0	9	9
217	R:R:R338	R:R:S342	3.95	No	No	0	9	9
218	R:R:F345	R:R:R341	10.69	No	No	0	8	9
219	R:R:F345	R:R:L391	10.96	No	No	0	8	7
220	R:R:F345	R:R:I395	3.77	No	No	0	8	5
221	R:R:L346	R:R:L350	6.92	No	No	2	9	9
222	R:R:V347	R:R:V352	11.22	No	No	2	8	6
223	R:R:L387	R:R:P348	4.93	No	No	0	6	9
224	R:R:L349	R:R:Y392	16.41	No	No	0	9	8
225	R:R:E354	R:R:H353	11.08	Yes	Yes	0	7	8
226	R:R:H353	R:R:L380	10.29	Yes	No	0	8	7
227	R:R:H353	R:R:Q384	9.89	Yes	No	0	8	9
228	R:R:E354	R:R:E377	17.76	Yes	Yes	1	7	7
229	R:R:F357	R:R:V356	3.93	Yes	No	0	7	6
230	R:R:F357	R:R:K373	9.93	Yes	No	1	7	7
231	R:R:F357	R:R:F376	8.57	Yes	No	0	7	4
232	R:R:E377	R:R:F357	4.66	Yes	Yes	1	7	7
233	R:R:K373	R:R:V360	4.55	No	No	0	7	4
234	R:R:E362	R:R:R370	12.79	No	No	0	5	5
235	L:L:D9	R:R:R370	11.91	No	No	0	0	5
236	R:R:E377	R:R:K373	9.45	Yes	No	1	7	7
237	R:R:F376	R:R:L380	6.09	No	No	0	4	7
238	L:L:A2	R:R:E377	4.53	No	Yes	0	0	7
239	L:L:F6	R:R:I378	5.02	Yes	No	7	0	8
240	R:R:F379	R:R:L380	3.65	No	No	0	6	7
241	R:R:F379	R:R:F383	8.57	No	No	0	6	6
242	L:L:E3	R:R:S381	7.19	No	No	1	0	5
243	R:R:F386	R:R:V390	6.55	No	No	0	5	5
244	R:R:V388	R:R:Y392	3.79	No	No	0	9	8
245	R:R:C393	R:R:F394	4.19	No	No	0	9	8
246	R:R:N396	R:R:V399	5.91	No	No	0	9	9
247	R:R:E402	R:R:R405	10.47	No	No	0	8	8
248	R:R:H409	R:R:R405	6.77	No	No	0	7	8
249	R:R:R411	R:R:W407	13.99	No	No	0	4	5
250	L:L:E3	L:L:Y1	11.22	No	Yes	1	0	0
251	L:L:G4	L:L:Y1	5.79	No	Yes	0	0	0
252	L:L:M14	L:L:Y10	10.78	No	No	0	0	0
253	L:L:D15	L:L:Q19	6.53	No	No	0	0	0
254	L:L:D21	L:L:N24	5.39	No	No	0	0	0
255	L:L:F22	L:L:W25	4.01	Yes	No	0	0	0
256	L:L:F22	L:L:L26	10.96	Yes	No	3	0	0
257	L:L:Q29	L:L:W25	17.52	No	No	0	0	0
258	R:R:N396	R:R:R169	3.62	No	No	0	9	9
259	R:R:A74	R:R:C103	3.61	No	No	0	7	9
260	R:R:A155	R:R:C393	3.61	No	No	0	9	9
261	R:R:A186	R:R:C226	3.61	No	No	0	6	6
262	R:R:P348	R:R:V347	3.53	No	No	0	9	8
263	R:R:L201	R:R:Y200	3.52	No	No	0	2	4
264	R:R:I298	R:R:W274	3.52	No	Yes	0	8	8
265	R:R:L280	R:R:Y281	3.52	No	No	0	3	3
266	R:R:L325	R:R:Y335	3.52	No	No	0	7	5
267	R:R:P302	R:R:T301	3.5	No	No	0	9	4
268	R:R:E48	R:R:R44	3.49	No	No	0	3	5
269	R:R:A155	R:R:S389	3.42	No	No	0	9	8
270	R:R:A229	R:R:S179	3.42	No	No	0	8	9
271	R:R:I272	R:R:P273	3.39	No	No	0	2	4
272	R:R:A186	R:R:T223	3.36	No	No	0	6	6
273	R:R:G351	R:R:H353	3.18	No	Yes	0	9	8
274	R:R:C226	R:R:L182	3.17	No	No	0	6	7
275	R:R:A184	R:R:L149	3.15	No	No	0	8	6
276	R:R:A215	R:R:L193	3.15	No	No	0	3	5
277	R:R:I174	R:R:S160	3.1	No	No	0	7	3
278	R:R:I395	R:R:V390	3.07	No	No	0	5	5
279	R:R:F383	R:R:G144	3.01	No	No	0	6	8
280	R:R:F270	R:R:G228	3.01	No	No	0	5	5
281	R:R:L321	R:R:S342	3	No	No	0	9	9
282	R:R:L235	R:R:V239	2.98	Yes	No	0	8	7
283	R:R:L339	R:R:T343	2.95	No	No	0	9	9
284	L:L:T5	R:R:L374	2.95	No	No	0	0	6
285	R:R:I158	R:R:I403	2.94	No	No	0	8	5
286	R:R:I313	R:R:I317	2.94	No	Yes	0	8	9
287	L:L:H18	R:R:A32	2.93	Yes	No	0	0	4
288	R:R:A95	R:R:H91	2.93	No	No	0	5	5
289	R:R:I320	R:R:K324	2.91	No	No	0	8	9
290	L:L:D9	L:L:T5	2.89	No	No	0	0	0
291	R:R:I133	R:R:L137	2.85	No	No	0	4	6
292	R:R:I309	R:R:L235	2.85	No	Yes	0	6	8
293	R:R:I276	R:R:L280	2.85	No	No	0	3	3
294	R:R:I317	R:R:L346	2.85	Yes	No	2	9	9
295	R:R:I378	R:R:L374	2.85	No	No	0	8	6
296	R:R:L149	R:R:M181	2.83	No	No	0	6	7
297	R:R:L153	R:R:M181	2.83	No	No	0	3	7
298	R:R:L156	R:R:M181	2.83	No	No	0	6	7
299	R:R:E253	R:R:T168	2.82	No	No	0	5	8
300	R:R:G198	R:R:W209	2.81	No	No	0	3	4
301	L:L:D21	L:L:I17	2.8	No	No	0	0	0
302	R:R:C332	R:R:R333	2.79	No	No	0	6	6
303	R:R:L325	R:R:L339	2.77	No	No	0	7	9
304	R:R:A268	R:R:Y225	2.67	No	No	0	3	8
305	R:R:F270	R:R:V271	2.62	No	No	0	5	6
306	R:R:F311	R:R:V352	2.62	No	No	0	6	6
307	R:R:A212	R:R:W209	2.59	No	No	0	6	4
308	R:R:S148	R:R:Y145	2.54	No	Yes	0	9	7
309	R:R:S243	R:R:Y259	2.54	No	Yes	0	7	8
310	L:L:I12	R:R:R289	2.51	No	Yes	0	0	4
311	R:R:F394	R:R:L154	2.44	No	No	0	8	5
312	R:R:L100	R:R:R81	2.43	Yes	No	0	4	4
313	R:R:L132	R:R:R136	2.43	No	No	0	3	4
314	R:R:L280	R:R:Y279	2.34	No	No	0	3	3
315	R:R:L100	R:R:W112	2.28	Yes	No	0	4	5
316	R:R:H166	R:R:R163	2.26	No	No	0	7	8
317	L:L:Q20	R:R:W90	2.19	No	Yes	0	0	4
318	R:R:G249	R:R:G250	2.11	No	No	0	7	6
319	R:R:G265	R:R:P267	2.03	No	Yes	0	6	9
320	R:R:A75	R:R:P76	1.87	No	No	0	2	4
321	R:R:A266	R:R:P267	1.87	No	Yes	0	4	9
322	R:R:A358	R:R:P359	1.87	No	No	0	6	5
323	R:R:G63	R:R:S64	1.86	No	No	0	4	6
324	R:R:G33	R:R:T31	1.82	No	No	0	5	5
325	R:R:A74	R:R:A80	1.79	No	No	0	7	6
326	R:R:G238	R:R:I313	1.76	No	No	0	9	8
327	R:R:G375	R:R:L137	1.71	No	No	0	5	6
328	R:R:C226	R:R:V222	1.71	No	No	0	6	5
329	R:R:G319	R:R:L322	1.71	No	No	0	8	5
330	R:R:A294	R:R:V292	1.7	No	No	0	3	6
331	R:R:A365	R:R:V360	1.7	No	No	0	6	4
332	R:R:A268	R:R:I272	1.62	No	No	0	3	2
333	R:R:V139	R:R:V143	1.6	No	No	0	3	5
334	L:L:H18	R:R:G202	1.59	Yes	No	0	0	1
335	R:R:T218	R:R:V222	1.59	No	No	0	3	5
336	R:R:G406	R:R:H409	1.59	No	No	0	5	7
337	L:L:A13	R:R:L134	1.58	No	No	0	0	5
338	R:R:A219	R:R:L193	1.58	No	No	0	6	5
339	R:R:A358	R:R:L304	1.58	No	No	0	6	4
340	R:R:I320	R:R:V246	1.54	No	No	0	8	7
341	R:R:L188	R:R:S146	1.5	No	No	0	7	7
342	R:R:L369	R:R:V360	1.49	No	No	0	4	4
343	R:R:L188	R:R:T142	1.47	No	No	0	7	7
344	R:R:I309	R:R:M305	1.46	No	No	0	6	4
345	R:R:D191	R:R:T142	1.45	No	No	0	7	7
346	R:R:P197	R:R:R196	1.44	No	No	0	4	3
347	L:L:I17	R:R:L128	1.43	No	No	0	0	3
348	R:R:Q364	R:R:T361	1.42	No	No	0	5	7
349	R:R:G63	R:R:W71	1.41	No	Yes	0	4	9
350	R:R:E363	R:R:T361	1.41	No	No	0	5	7
351	R:R:A219	R:R:R190	1.38	No	Yes	0	6	6
352	R:R:L322	R:R:L339	1.38	No	No	0	5	9
353	R:R:D129	R:R:L132	1.36	No	No	0	1	3
354	L:L:K16	L:L:Q19	1.36	No	No	0	0	0
355	R:R:E135	R:R:L132	1.33	No	No	0	3	3
356	R:R:R164	R:R:S401	1.32	No	No	0	7	4
357	R:R:A80	R:R:W71	1.3	No	Yes	0	6	9
358	L:L:V23	R:R:Y68	1.26	No	No	0	0	5
359	R:R:M330	R:R:R331	1.24	No	No	0	5	5
360	R:R:Q47	R:R:R43	1.17	No	No	0	3	4
361	R:R:E40	R:R:R44	1.16	No	No	0	3	5
362	R:R:R38	R:R:Y87	1.03	No	Yes	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:W39	7.422	5	3	6
2	R:R:Y42	7.6025	4	3	7
3	R:R:F65	5.5425	4	0	7
4	R:R:W71	4.87286	7	0	9
5	R:R:P85	7.01	4	3	8
6	R:R:Y87	7.64	4	3	4
7	R:R:W90	8.54333	6	6	4
8	R:R:L100	4.3175	4	0	4
9	R:R:Y141	5.09	4	7	7
10	R:R:Y145	5.49167	6	0	7
11	R:R:F180	10.435	4	0	8
12	R:R:R183	6.91	6	1	8
13	R:R:R190	7.795	4	0	6
14	R:R:Q224	6.062	5	1	6
15	R:R:Y231	6.665	4	1	8
16	R:R:W233	10.5925	4	0	9
17	R:R:L235	5.0175	4	0	8
18	R:R:E237	8.785	4	0	9
19	R:R:Y240	6.365	4	0	8
20	R:R:Y259	4.54	5	0	8
21	R:R:P267	5.152	5	0	9
22	R:R:W274	8.5025	4	1	8
23	R:R:R278	10.9075	4	0	8
24	R:R:W287	9.248	5	4	9
25	R:R:E288	5.6575	4	0	6
26	R:R:R289	5.03333	6	0	4
27	R:R:W296	11.8225	4	1	6
28	R:R:F314	8.092	5	2	9
29	R:R:I317	3.945	4	2	9
30	R:R:H353	8.61	4	0	8
31	R:R:E354	9.98	4	1	7
32	R:R:F357	6.7725	4	1	7
33	R:R:E377	9.1	4	1	7
34	L:L:Y1	8.694	5	1	0
35	L:L:F6	6.3625	4	7	0
36	L:L:H18	3.635	4	0	0
37	L:L:F22	8.11	5	3	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:D15	L:L:Q19	66.0423	6.53	No	No	0	0	0
2	L:L:D15	R:R:R289	66.7357	4.76	No	Yes	0	0	4
3	L:L:Q19	R:R:L35	64.6503	3.99	No	No	0	0	5
4	L:L:F22	R:R:L35	63.95	7.31	Yes	No	0	0	5
5	L:L:F22	R:R:W39	54.6662	10.02	Yes	Yes	3	0	6
6	R:R:F65	R:R:W39	10.9959	5.01	Yes	Yes	0	7	6
7	R:R:W39	R:R:Y87	42.3001	8.68	Yes	Yes	3	6	4
8	R:R:P85	R:R:Y87	36.0883	6.95	Yes	Yes	3	8	4
9	R:R:V69	R:R:W71	21.9222	4.9	No	Yes	0	5	9
10	R:R:P85	R:R:V69	22.713	10.6	Yes	No	0	8	5
11	R:R:D66	R:R:W71	13.1117	7.82	No	Yes	0	9	9
12	R:R:D66	R:R:R113	11.4761	5.96	No	No	5	9	6
13	R:R:L88	R:R:W90	13.1813	6.83	No	Yes	0	5	4
14	R:R:L88	R:R:P85	13.9913	4.93	No	Yes	0	5	8
15	L:L:L27	R:R:R113	10.7131	3.64	No	No	0	0	6
16	R:R:Q138	R:R:Y141	10.547	4.51	No	Yes	0	5	7
17	R:R:Y141	R:R:Y145	20.1265	3.97	Yes	Yes	0	7	7
18	R:R:R183	R:R:Y145	24.7088	5.14	Yes	Yes	0	8	7
19	R:R:R183	R:R:V227	50.974	9.15	Yes	No	0	8	6
20	L:L:Y1	R:R:V227	50.7365	12.62	Yes	No	0	0	6
21	L:L:Y1	R:R:Q224	96.7793	9.02	Yes	Yes	1	0	6
22	R:R:Q224	R:R:W274	83.203	6.57	Yes	Yes	1	6	8
23	R:R:R278	R:R:W274	82.018	11	Yes	Yes	0	8	8
24	R:R:R278	R:R:T284	71.5781	3.88	Yes	No	0	8	4
25	R:R:R289	R:R:T284	70.9204	3.88	Yes	No	0	4	4
26	L:L:E3	R:R:R183	50.9731	8.14	No	Yes	1	0	8
27	L:L:E3	L:L:Y1	50.8591	11.22	No	Yes	1	0	0
28	R:R:N230	R:R:R183	98.0521	9.64	No	Yes	0	9	8
29	R:R:F180	R:R:N230	49.3279	20.54	Yes	No	0	8	9
30	R:R:F180	R:R:L176	51.8692	7.31	Yes	No	0	8	9
31	R:R:E237	R:R:L176	100	5.3	Yes	No	0	9	9
32	R:R:E237	R:R:H173	41.8573	11.08	Yes	No	0	9	9
33	R:R:H173	R:R:Y392	33.0364	7.62	No	No	0	9	8
34	R:R:V388	R:R:Y392	63.8177	3.79	No	No	0	9	8
35	R:R:F177	R:R:V388	62.5554	3.93	No	No	0	9	9
36	R:R:F177	R:R:L152	61.2912	4.87	No	No	0	9	9
37	R:R:L152	R:R:S389	60.0254	6.01	No	No	0	9	8
38	R:R:S389	R:R:T151	51.1419	4.8	No	No	0	8	7
39	R:R:F386	R:R:T151	49.8621	7.78	No	No	0	5	7
40	R:R:L234	R:R:N230	48.7485	4.12	No	No	0	9	9
41	R:R:L176	R:R:L234	48.5989	4.15	No	No	0	9	9
42	R:R:E237	R:R:L349	32.6649	11.93	Yes	No	0	9	9
43	R:R:L349	R:R:Y392	32.0655	16.41	No	No	0	9	8
44	R:R:H173	R:R:R169	10.192	4.51	No	No	0	9	9
45	R:R:E237	R:R:I172	35.9831	6.83	Yes	No	0	9	9
46	R:R:I172	R:R:Y240	32.6553	3.63	No	Yes	0	9	8
47	R:R:Y240	R:R:Y259	29.2841	4.96	Yes	Yes	0	8	8
48	R:R:V236	R:R:Y259	21.7142	3.79	No	Yes	0	8	8
49	R:R:V236	R:R:W233	20.3153	4.9	No	Yes	0	8	9
50	R:R:Q220	R:R:Q224	13.4093	5.12	No	Yes	0	5	6
51	R:R:Q220	R:R:R190	12.6785	8.18	No	Yes	0	5	6
52	R:R:W233	R:R:W264	10.9306	16.87	Yes	No	0	9	9
53	R:R:F386	R:R:V390	47.2974	6.55	No	No	0	5	5
54	R:R:I395	R:R:V390	46.0124	3.07	No	No	0	5	5
55	R:R:F345	R:R:I395	44.7239	3.77	No	No	0	8	5
56	R:R:F345	R:R:R341	42.1739	10.69	No	No	0	8	9
57	R:R:R338	R:R:R341	40.882	7.46	No	No	0	9	9
58	R:R:L325	R:R:R338	37.0262	4.86	No	No	0	7	9
59	R:R:L325	R:R:L339	33.1242	2.77	No	No	0	7	9
60	R:R:L339	R:R:T343	29.2067	2.95	No	No	0	9	9
61	R:R:L318	R:R:T343	27.8973	7.37	No	No	0	7	9
62	R:R:F314	R:R:L318	26.5862	8.53	Yes	No	0	9	7
63	R:R:F314	R:R:L346	14.6986	7.31	Yes	No	2	9	9
64	R:R:I317	R:R:L346	13.3797	2.85	Yes	No	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:R289	R:R:T31	6.47	0	Yes	No	4	5	1	2
L:L:Q19	R:R:L35	3.99	0	No	No	0	5	0	1
L:L:F22	R:R:L35	7.31	3	Yes	No	0	5	0	1
L:L:H18	R:R:Y36	5.44	0	Yes	No	0	3	0	1
L:L:F22	R:R:Y36	8.25	3	Yes	No	0	3	0	1
R:R:F65	R:R:W39	5.01	0	Yes	Yes	7	6	2	1
R:R:W39	R:R:Y87	8.68	3	Yes	Yes	6	4	1	2
R:R:Q204	R:R:W39	6.57	0	No	Yes	4	6	2	1
L:L:F22	R:R:W39	10.02	3	Yes	Yes	0	6	0	1
L:L:L26	R:R:W39	6.83	3	No	Yes	0	6	0	1
R:R:D66	R:R:W71	7.82	5	No	Yes	9	9	1	2
R:R:D66	R:R:R113	5.96	5	No	No	9	6	1	1
L:L:K30	R:R:D66	5.53	5	No	No	0	9	0	1
L:L:Q29	R:R:M67	17.67	0	No	No	0	3	0	1
R:R:C118	R:R:Y68	5.38	0	No	No	9	5	2	1
R:R:R101	R:R:W71	6	0	No	Yes	8	9	1	2
R:R:L88	R:R:W90	6.83	0	No	Yes	5	4	2	1
R:R:P89	R:R:W90	9.46	0	No	Yes	3	4	2	1
R:R:V94	R:R:W90	6.13	0	No	Yes	3	4	2	1
R:R:N120	R:R:W90	22.6	6	No	Yes	3	4	2	1
R:R:P121	R:R:W90	4.05	6	No	Yes	2	4	2	1
L:L:K30	R:R:R101	8.66	5	No	No	0	8	0	1
L:L:L27	R:R:R113	3.64	0	No	No	0	6	0	1
L:L:K30	R:R:R113	19.8	5	No	No	0	6	0	1
R:R:E119	R:R:H115	3.69	0	No	No	1	7	2	1
L:L:L27	R:R:H115	10.29	0	No	No	0	7	0	1
R:R:N120	R:R:P121	6.52	6	No	No	3	2	2	2
R:R:F127	R:R:N124	4.83	0	No	No	2	1	2	1
L:L:Q20	R:R:N124	11.88	0	No	No	0	1	0	1
R:R:E135	R:R:R131	8.14	0	No	No	3	3	2	1
L:L:M14	R:R:R131	9.93	0	No	No	0	3	0	1
L:L:I17	R:R:R131	3.76	0	No	No	0	3	0	1
L:L:F6	R:R:L134	6.09	7	Yes	No	0	5	0	1
L:L:Y10	R:R:L134	7.03	0	No	No	0	5	0	1
L:L:F6	R:R:L137	6.09	7	Yes	No	0	6	0	1
R:R:Q138	R:R:Y141	4.51	0	No	Yes	5	7	1	1
R:R:D191	R:R:Q138	9.14	0	No	No	7	5	2	1
L:L:Y10	R:R:Q138	4.51	0	No	No	0	5	0	1
R:R:Y141	R:R:Y145	3.97	7	Yes	Yes	7	7	1	2
R:R:I378	R:R:Y141	3.63	7	No	Yes	8	7	1	1
L:L:F6	R:R:Y141	8.25	7	Yes	Yes	0	7	0	1
R:R:R183	R:R:Y145	5.14	1	Yes	Yes	8	7	1	2
R:R:R183	R:R:V227	9.15	1	Yes	No	8	6	1	1
R:R:N230	R:R:R183	9.64	0	No	Yes	9	8	2	1
R:R:R183	R:R:Y231	4.12	1	Yes	Yes	8	8	1	2
R:R:R183	R:R:S381	5.27	1	Yes	No	8	5	1	1
L:L:E3	R:R:R183	8.14	1	No	Yes	0	8	0	1
R:R:Q220	R:R:R190	8.18	0	No	Yes	5	6	2	1
R:R:R190	R:R:T223	10.35	0	Yes	No	6	6	1	2
L:L:I7	R:R:R190	11.27	0	No	Yes	0	6	0	1
R:R:E288	R:R:L194	3.98	0	Yes	No	6	7	1	2
R:R:G198	R:R:P199	4.06	0	No	No	3	3	2	1
L:L:H18	R:R:P199	4.58	0	Yes	No	0	3	0	1
R:R:Q220	R:R:Q224	5.12	0	No	Yes	5	6	2	1
R:R:Q224	R:R:W274	6.57	1	Yes	Yes	6	8	1	2
R:R:Q224	R:R:W296	5.48	1	Yes	Yes	6	6	1	1
R:R:I299	R:R:Q224	4.12	1	No	Yes	7	6	2	1
L:L:Y1	R:R:Q224	9.02	1	Yes	Yes	0	6	0	1
L:L:Y1	R:R:V227	12.62	1	Yes	No	0	6	0	1
R:R:E354	R:R:Y231	5.61	1	Yes	Yes	7	8	2	2
R:R:I299	R:R:W274	12.92	1	No	Yes	7	8	2	2
R:R:R289	R:R:T284	3.88	0	Yes	No	4	4	1	2
R:R:Q285	R:R:R289	4.67	0	No	Yes	3	4	2	1
R:R:C286	R:R:E288	4.56	0	No	Yes	9	6	2	1
L:L:I7	R:R:E288	5.47	0	No	Yes	0	6	0	1
L:L:S11	R:R:E288	8.62	0	No	Yes	0	6	0	1
L:L:S11	R:R:R289	7.91	0	No	Yes	0	4	0	1
L:L:D15	R:R:R289	4.76	0	No	Yes	0	4	0	1
R:R:N290	R:R:W296	25.99	0	No	Yes	6	6	1	1
L:L:S8	R:R:N290	7.45	0	No	No	0	6	0	1
R:R:R300	R:R:W296	11	0	No	Yes	7	6	2	1
L:L:Y1	R:R:W296	4.82	1	Yes	Yes	0	6	0	1
R:R:E354	R:R:E377	17.76	1	Yes	Yes	7	7	2	1
R:R:F357	R:R:K373	9.93	1	Yes	No	7	7	2	2
R:R:E377	R:R:F357	4.66	1	Yes	Yes	7	7	1	2
R:R:E362	R:R:R370	12.79	0	No	No	5	5	2	1
L:L:D9	R:R:R370	11.91	0	No	No	0	5	0	1
R:R:E377	R:R:K373	9.45	1	Yes	No	7	7	1	2
L:L:A2	R:R:E377	4.53	0	No	Yes	0	7	0	1
L:L:F6	R:R:I378	5.02	7	Yes	No	0	8	0	1
L:L:E3	R:R:S381	7.19	1	No	No	0	5	0	1
L:L:T5	R:R:L374	2.95	0	No	No	0	6	0	1
L:L:H18	R:R:A32	2.93	0	Yes	No	0	4	0	1
R:R:I133	R:R:L137	2.85	0	No	No	4	6	2	1
R:R:I378	R:R:L374	2.85	7	No	No	8	6	1	1
L:L:I12	R:R:R289	2.51	0	No	Yes	0	4	0	1
L:L:Q20	R:R:W90	2.19	0	No	Yes	0	4	0	1
R:R:G375	R:R:L137	1.71	0	No	No	5	6	2	1
L:L:H18	R:R:G202	1.59	0	Yes	No	0	1	0	1
L:L:A13	R:R:L134	1.58	0	No	No	0	5	0	1
L:L:I17	R:R:L128	1.43	0	No	No	0	3	0	1
R:R:A219	R:R:R190	1.38	0	No	Yes	6	6	2	1
L:L:V23	R:R:Y68	1.26	0	No	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7DTY_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.63
Number of Linked Nodes	345
Number of Links	362
Number of Hubs	37
Number of Links mediated by Hubs	145
Number of Communities	8
Number of Nodes involved in Communities	45
Number of Links involved in Communities	53

Path Summary
Number Of Nodes in MetaPath	65
Number Of Links MetaPath	64
Number of Shortest Paths	159753
Length Of Smallest Path	3
Average Path Length	24.5968
Length of Longest Path	58
Minimum Path Strength	1.345
Average Path Strength	6.92386
Maximum Path Strength	18.63
Minimum Path Correlation	0.7
Average Path Correlation	0.955693
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.32558
Average % Of Corr. Nodes	47.1154
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.3196
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• response to stimulus • response to stress • response to wounding • response to axon injury • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • response to metal ion • response to chemical • response to calcium ion • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • negative adaptation of signaling pathway • negative regulation of signaling • negative regulation of biological process • desensitization of G protein-coupled receptor signaling pathway • regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • regulation of response to stimulus • adaptation of signaling pathway • regulation of cell communication • metabolic process • generation of precursor metabolites and energy • response to hexose • response to monosaccharide • response to carbohydrate • response to glucose • response to oxygen-containing compound • gastric inhibitory peptide signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • developmental process • multicellular organism development • multicellular organismal process • pancreas development • endocrine system development • anatomical structure development • animal organ development • endocrine pancreas development • system development • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • cell surface receptor signaling pathway • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to lipid • response to fatty acid • response to nutrient levels • response to nutrient • positive regulation of cell communication • positive regulation of establishment of protein localization • positive regulation of insulin secretion • positive regulation of peptide hormone secretion • positive regulation of protein localization • positive regulation of biological process • positive regulation of secretion by cell • positive regulation of protein transport • positive regulation of hormone secretion • positive regulation of secretion • positive regulation of cellular process • positive regulation of peptide secretion • positive regulation of protein secretion • positive regulation of transport • positive regulation of signaling • cellular anatomical structure • membrane • cell periphery • plasma membrane • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • glucagon receptor binding • gastric inhibitory polypeptide receptor binding • molecular transducer activity • molecular function activator activity • signaling receptor activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • response to acid chemical • response to amino acid • response to xenobiotic stimulus • adult locomotory behavior • behavior • adult behavior • locomotory behavior • response to hormone • response to endogenous stimulus • response to peptide hormone • response to nitrogen compound • response to selenium ion • exploration behavior • multi-multicellular organism process • reproductive process • female pregnancy • multi-organism reproductive process • chemical homeostasis • homeostatic process • triglyceride homeostasis • acylglycerol homeostasis • lipid homeostasis • system process • learning or memory • nervous system process • cognition • memory • digestive system development • oxoacid metabolic process • ketone metabolic process • regulation of lipid metabolic process • lipid biosynthetic process • organic acid biosynthetic process • organic acid metabolic process • carboxylic acid biosynthetic process • regulation of primary metabolic process • regulation of small molecule metabolic process • small molecule metabolic process • regulation of biosynthetic process • fatty acid metabolic process • monocarboxylic acid biosynthetic process • small molecule biosynthetic process • carboxylic acid metabolic process • primary metabolic process • fatty acid biosynthetic process • regulation of ketone metabolic process • biosynthetic process • regulation of fatty acid biosynthetic process • regulation of fatty acid metabolic process • regulation of lipid biosynthetic process • monocarboxylic acid metabolic process • regulation of metabolic process • lipid metabolic process • sensory perception • sensory perception of pain • positive regulation of signal transduction • intracellular signal transduction • positive regulation of cAMP/PKA signal transduction • positive regulation of response to stimulus • cAMP/PKA signal transduction • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of intracellular signal transduction • regulation of cAMP/PKA signal transduction • hexose transmembrane transport • carbohydrate transport • positive regulation of D-glucose transmembrane transport • transmembrane transport • regulation of transmembrane transport • D-glucose transmembrane transport • positive regulation of transmembrane transport • regulation of D-glucose transmembrane transport • monosaccharide transmembrane transport • carbohydrate transmembrane transport • response to pH • response to abiotic stimulus • response to acidic pH • modulation of chemical synaptic transmission • long-term synaptic potentiation • synaptic signaling • regulation of synaptic plasticity • trans-synaptic signaling • positive regulation of synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • response to starvation • membrane-bounded organelle • intracellular anatomical structure • membrane-enclosed lumen • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle lumen • endoplasmic reticulum lumen • intracellular organelle • organelle lumen • organelle • endoplasmic reticulum • cytoplasm • extracellular region • vesicle lumen • intracellular vesicle • cytoplasmic vesicle lumen • secretory granule lumen • cytoplasmic vesicle • secretory granule • secretory vesicle • vesicle • somatodendritic compartment • cell body • neuronal cell body • extracellular space • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to oxygen levels • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • photoreceptor inner segment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • response to ketone • response to prostaglandin • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • mu-type opioid receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • adrenergic receptor binding • D1 dopamine receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • ionotropic glutamate receptor binding • glutamate receptor binding • enzyme regulator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • insulin-like growth factor receptor binding • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• FnI-like domain • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• FnI-like domain • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P48546
Sequence	>7DTY_nogp_Chain_R T A G E L Y Q R W E R Y R R E C Q E T A C N G S F D M Y V C W D Y A A P N A T A R A S C P W Y L P W H H H V A A G F V L R Q C W R D H T Q C E N P E K N E A F L D Q R L I L E R L Q V M Y T V G Y S L S L A T L L L A L L I L S L F R R L H C T R N Y I H I N L F T S F M L R A A A I L S R D R L L P R P G P Y L G D Q A L A L W N Q A L A A C R T A Q I V T Q Y C V G A N Y T W L L V E G V Y L H S L L V L V G G S E E G H F R Y Y L L L G W G A P A L F V I P W V I V R Y L Y E N T Q C W E R N E V K A I W W I I R T P I L M T I L I N F L I F I R I L G I L L S K L R T R Q M R C R D Y R L R L A R S T L F L V P L L G V H E V V F A P V T E E Q A R G A L R F A K L G F E I F L S S F Q G F L V S V L Y C F I N K E V Q S E I R R G W H H C R L R R S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YW4	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ22	3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW4 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-		3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8WA3	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	2.86	2024-03-06	10.1038/s41421-024-00649-0
	8WA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		2.86	2024-03-06	10.1038/s41421-024-00649-0
	8ITM	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.13	2023-10-18	10.1073/pnas.2306145120
	8ITM (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.13	2023-10-18	10.1073/pnas.2306145120
	8ITL	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.23	2023-10-18	10.1073/pnas.2306145120
	8ITL (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.23	2023-10-18	10.1073/pnas.2306145120
	7RBT	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	PubChem 163183774	chim(NtGi1-Gs)/β1/γ2	3.08	2022-04-13	10.1073/pnas.2116506119
	7RBT (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	PubChem 163183774		3.08	2022-04-13	10.1073/pnas.2116506119
	7RA3	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	chim(NtGi1-Gs)/β1/γ2	3.24	2022-04-13	10.1073/pnas.2116506119
	7RA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		3.24	2022-04-13	10.1073/pnas.2116506119
	7VAB	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-03-02	10.1038/s41467-022-28683-0
	7VAB (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-		3.2	2022-03-02	10.1038/s41467-022-28683-0
	7FIY	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	10.1038/s41467-022-28683-0
	7FIY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	10.1038/s41467-022-28683-0
	7FIN	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-	Gs/β1/γ2	3.1	2022-02-23	10.1038/s41467-022-28683-0
	7FIN (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-		3.1	2022-02-23	10.1038/s41467-022-28683-0
	7DTY	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	Gs/β1/γ2	2.98	2021-08-04	10.7554/eLife.68719
	7DTY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		2.98	2021-08-04	10.7554/eLife.68719

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Download 7DTY_nogp.zip

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