Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:Y141 9.01527
2R:R:V143 2.065445
3R:R:Y145 10.12427
4R:R:T151 4.0975417
5R:R:L152 5.52519
6R:R:F162 9.472507
7R:R:R169 8.01519
8R:R:N170 3.6519
9R:R:I172 3.27429719
10R:R:H173 12.64419
11R:R:N175 5.8725419
12R:R:F177 3.225619
13R:R:F180 7.26429718
14R:R:R183 5.518518
15R:R:R190 6.445626
16R:R:L194 5.445427
17R:R:Y225 4.21408
18R:R:Y231 5.56568
19R:R:W233 8.79167619
20R:R:L235 4.255408
21R:R:V236 4.015418
22R:R:E237 5.6375419
23R:R:Y240 4.785618
24R:R:H242 5.0925478
25R:R:F256 4.2675405
26R:R:Y259 3.992518
27R:R:G263 3.985419
28R:R:W264 6.22857719
29R:R:P267 4.765609
30R:R:W274 4.90167658
31R:R:W287 9.64429
32R:R:L325 4.0675407
33R:R:D334 4.3525406
34R:R:V352 7.32466
35R:R:R370 3.86505
36R:R:L374 3.638536
37R:R:S381 4.47425
38R:R:Q384 5.285419
39R:R:F386 7.8825415
40R:R:V390 6.31415
41R:R:L391 4.1075417
42R:R:F394 5.625418
43R:R:E398 6.475419
44R:R:R405 4.45408
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F371 R:R:R370 12.41534.28NoYes045
2R:R:F371 R:R:I133 14.22493.77NoNo044
3R:R:I133 R:R:L134 16.01492.85NoNo045
4R:R:L134 R:R:L374 16.7254.15NoYes356
5R:R:I378 R:R:L374 21.03471.43NoYes086
6R:R:I378 R:R:Y141 22.674214.51NoYes087
7R:R:I187 R:R:Y141 36.29373.63NoYes277
8R:R:S381 R:R:Y141 14.9712.54YesYes257
9R:R:S381 R:R:S382 12.73271.63YesNo059
10R:R:G144 R:R:S382 10.93293.71NoNo089
11R:R:I187 R:R:R190 52.19416.26NoYes276
12R:R:A219 R:R:R190 67.55132.77NoYes066
13R:R:A219 R:R:S189 68.00611.71NoNo065
14R:R:A186 R:R:S189 68.45451.71NoNo065
15R:R:A186 R:R:V222 69.33153.39NoNo065
16R:R:L182 R:R:V222 70.18232.98NoNo075
17R:R:C226 R:R:L182 15.34084.76NoNo067
18R:R:C226 R:R:R183 14.34934.18NoYes168
19R:R:F180 R:R:R183 11.64635.34YesYes188
20R:R:F180 R:R:L152 18.51833.65YesYes189
21R:R:S389 R:R:T151 10.70063.2NoYes187
22R:R:L182 R:R:Y225 57.40042.34NoYes078
23R:R:W264 R:R:Y225 51.05537.72YesYes098
24R:R:W233 R:R:W264 75.205317.81YesYes199
25R:R:I172 R:R:W233 84.19784.7YesYes199
26R:R:H173 R:R:I172 44.46152.65YesYes199
27R:R:H173 R:R:R169 41.784719.18YesYes199
28R:R:N170 R:R:R169 23.07672.41YesYes199
29R:R:L159 R:R:N170 13.35452.75NoYes089
30R:R:I172 R:R:Y240 45.9214.84YesYes198
31R:R:R169 R:R:Y240 50.01154.12YesYes198
32R:R:N396 R:R:R169 59.046410.85NoYes199
33R:R:N396 R:R:V399 55.99337.39NoNo099
34R:R:F162 R:R:V399 52.96972.62YesNo079
35R:R:E402 R:R:F162 20.219917.49NoYes087
36R:R:F162 R:R:I403 26.76466.28YesNo075
37R:R:E402 R:R:R164 16.865713.96NoNo087
38R:R:V236 R:R:Y259 15.2233.79YesYes188
39R:R:L176 R:R:L234 10.82172.77NoNo099
40R:R:A229 R:R:W264 18.23693.89NoYes189
41R:R:A229 R:R:P267 19.02223.74NoYes089
42R:R:P267 R:R:Y225 41.98442.78YesYes098
43R:R:S179 R:R:W264 16.68584.94NoYes199
44R:R:Q220 R:R:R190 19.43458.18NoYes256
45R:R:Q220 R:R:Q224 18.962.56NoNo056
46R:R:Q224 R:R:W274 17.07527.67NoYes068
47R:R:R278 R:R:W274 12.24525NoYes088
48R:R:G228 R:R:P267 96.06014.06NoYes059
49R:R:G228 R:R:I303 94.95731.76NoNo057
50R:R:I303 R:R:Y231 93.90693.63NoYes078
51R:R:V352 R:R:Y231 1007.57YesYes668
52R:R:G263 R:R:W233 17.01957.04YesYes199
53R:R:P267 R:R:T232 42.010512.24YesNo096
54R:R:G263 R:R:T232 41.87313.64YesNo096
55R:R:I307 R:R:V352 75.617716.9NoYes076
56R:R:I307 R:R:N310 61.95232.83NoNo079
57R:R:L235 R:R:N310 60.38818.24YesNo089
58R:R:I309 R:R:L235 55.65632.85NoYes068
59R:R:I309 R:R:I313 52.4692.94NoNo068
60R:R:H242 R:R:I313 47.52452.65YesNo788
61R:R:H242 R:R:V246 44.45178.3YesNo087
62R:R:I320 R:R:V246 42.8091.54NoNo087
63R:R:V352 R:R:V356 28.00811.6YesNo066
64R:R:R300 R:R:V356 26.30659.15NoNo076
65R:R:R300 R:R:W296 22.883624.99NoNo076
66R:R:W296 R:R:W297 21.16239.37NoNo067
67R:R:K293 R:R:W297 12.457910.44NoNo057
68R:R:K293 R:R:V292 10.69733.04NoNo056
69R:R:I307 R:R:L349 14.0944.28NoNo079
70R:R:I320 R:R:K324 39.6251.45NoNo089
71R:R:K324 R:R:T327 36.30681.5NoNo096
72R:R:R328 R:R:T327 34.63791.29NoNo066
73R:R:M330 R:R:R328 32.96257.44NoNo056
74R:R:D334 R:R:M330 31.28056.93YesNo065
75R:R:D334 R:R:L325 21.05118.14YesYes067
76R:R:E354 R:R:S381 14.5268.62NoYes075
77R:R:R164 R:R:R405 13.5051.07NoYes078
78R:R:I403 R:R:R404 23.56756.26NoNo056
79R:R:H408 R:R:R404 20.21992.26NoNo046
80R:R:H408 R:R:W407 16.86577.41NoNo045
81R:R:S381 R:R:Y145 13.66215.09YesYes257
82R:R:I187 R:R:Y145 15.25259.67NoYes277
83R:R:N230 R:R:S179 17.20617.45NoNo199
84R:R:F180 R:R:N230 14.470425.37YesNo189
85R:R:L234 R:R:Y231 11.55472.34NoYes098
86R:R:I172 R:R:V236 15.95933.07YesYes198
87R:R:G263 R:R:V236 25.94331.84YesYes198
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8ITL_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 1.71
Number of Linked Nodes 265
Number of Links 309
Number of Hubs 44
Number of Links mediated by Hubs 164
Number of Communities 9
Number of Nodes involved in Communities 70
Number of Links involved in Communities 98
Path Summary
Number Of Nodes in MetaPath 88
Number Of Links MetaPath 87
Number of Shortest Paths 64317
Length Of Smallest Path 3
Average Path Length 18.1358
Length of Longest Path 44
Minimum Path Strength 1.17
Average Path Strength 5.7196
Maximum Path Strength 24.035
Minimum Path Correlation 0.7
Average Path Correlation 0.940229
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 2.85714
Average % Of Corr. Nodes 44.5778
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.4816
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• response to stimulus   • response to stress   • response to wounding   • response to axon injury   • positive regulation of cytosolic calcium ion concentration   • biological regulation   • regulation of biological quality   • response to metal ion   • response to chemical   • response to calcium ion   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • signaling   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • negative adaptation of signaling pathway   • negative regulation of signaling   • negative regulation of biological process   • desensitization of G protein-coupled receptor signaling pathway   • regulation of signal transduction   • negative regulation of G protein-coupled receptor signaling pathway   • negative regulation of cell communication   • negative regulation of cellular process   • regulation of G protein-coupled receptor signaling pathway   • regulation of signaling   • negative regulation of response to stimulus   • negative regulation of signal transduction   • regulation of response to stimulus   • adaptation of signaling pathway   • regulation of cell communication   • metabolic process   • generation of precursor metabolites and energy   • response to hexose   • response to monosaccharide   • response to carbohydrate   • response to glucose   • response to oxygen-containing compound   • gastric inhibitory peptide signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • developmental process   • multicellular organism development   • multicellular organismal process   • pancreas development   • endocrine system development   • anatomical structure development   • animal organ development   • endocrine pancreas development   • system development   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • cell surface receptor signaling pathway   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to lipid   • response to fatty acid   • response to nutrient levels   • response to nutrient   • positive regulation of cell communication   • positive regulation of establishment of protein localization   • positive regulation of insulin secretion   • positive regulation of peptide hormone secretion   • positive regulation of protein localization   • positive regulation of biological process   • positive regulation of secretion by cell   • positive regulation of protein transport   • positive regulation of hormone secretion   • positive regulation of secretion   • positive regulation of cellular process   • positive regulation of peptide secretion   • positive regulation of protein secretion   • positive regulation of transport   • positive regulation of signaling   • cellular anatomical structure   • membrane   • cell periphery   • plasma membrane   • peptide hormone receptor binding   • protein binding   • binding   • corticotropin-releasing hormone receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • corticotropin-releasing hormone receptor 1 binding   • hormone receptor binding   • neuropeptide receptor binding   • mu-type opioid receptor binding   • opioid receptor binding   • beta-2 adrenergic receptor binding   • adrenergic receptor binding   • D1 dopamine receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • ionotropic glutamate receptor binding   • glutamate receptor binding   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • metal ion binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • insulin-like growth factor receptor binding   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • intracellular anatomical structure   • cytoplasm   • cytoskeletal protein binding   • spectrin binding   • enzyme binding   • GTPase binding   • phosphoric ester hydrolase activity   • alkylglycerophosphoethanolamine phosphodiesterase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of taste   • sensory organ development   • eye development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • response to decreased oxygen levels   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • cellular response to stress   • response to hypoxia   • response to oxygen levels   • response to abiotic stimulus   • cell population proliferation   • phospholipase C-activating G protein-coupled receptor signaling pathway   • muscle cell apoptotic process   • striated muscle cell apoptotic process   • apoptotic process   • cell death   • programmed cell death   • cardiac muscle cell apoptotic process   • photoreceptor inner segment   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor outer segment   • photoreceptor cell cilium   • organelle   • ciliary membrane   • photoreceptor outer segment membrane   • bounding membrane of organelle   • plasma membrane region   • organelle membrane   • cell projection membrane   • synapse   • cell junction   • cell body   • G-protein beta-subunit binding   • response to ketone   • response to prostaglandin   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus
Gene OntologyCellular Component
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP48546
Sequence
>8ITL_nogp_Chain_R
NEAFLDQRL ILERLQVMY TVGYSLSLA TLLLALLIL SLFRRLHCT 
RNYIHINLF TSFMLRAAA ILSRDRLLP NQALAACRT AQIVTQYCV 
GANYTWLLV EGVYLHSLL VLVGGSEEG HFRYYLLLG WGAPALFVI 
PWVIVRYLY ENTQCWERN EVKAIWWII RTPILMTIL INFLIFIRI 
LGILLSKLR TRQMRCRDY RLRLARSTL FLVPLLGVH EVVFAPVTE 
EQARGALRF AKLGFEIFL SSFQGFLVS VLYCFINKE VQSEIRRGW 
HHCRLRRS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8YW4B1PeptideGlucagonGIPHomo sapiensRetatrutide-chim(NtGi1-Gs)/β1/γ223.262024-09-18doi.org/10.1038/s41421-024-00700-0
8YW4 (No Gprot) B1PeptideGlucagonGIPHomo sapiensRetatrutide-3.262024-09-18doi.org/10.1038/s41421-024-00700-0
8WA3B1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ22.862024-03-0610.1038/s41421-024-00649-0
8WA3 (No Gprot) B1PeptideGlucagonGIPHomo sapiens--2.862024-03-0610.1038/s41421-024-00649-0
8ITMB1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ23.132023-10-1810.1073/pnas.2306145120
8ITM (No Gprot) B1PeptideGlucagonGIPHomo sapiens--3.132023-10-1810.1073/pnas.2306145120
8ITLB1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ23.232023-10-1810.1073/pnas.2306145120
8ITL (No Gprot) B1PeptideGlucagonGIPHomo sapiens--3.232023-10-1810.1073/pnas.2306145120
7RBTB1PeptideGlucagonGIPHomo sapiensTirzepatidePubChem 163183774chim(NtGi1-Gs)/β1/γ23.082022-04-1310.1073/pnas.2116506119
7RBT (No Gprot) B1PeptideGlucagonGIPHomo sapiensTirzepatidePubChem 1631837743.082022-04-1310.1073/pnas.2116506119
7RA3B1PeptideGlucagonGIPHomo sapiensGIP-chim(NtGi1-Gs)/β1/γ23.242022-04-1310.1073/pnas.2116506119
7RA3 (No Gprot) B1PeptideGlucagonGIPHomo sapiensGIP-3.242022-04-1310.1073/pnas.2116506119
7VABB1PeptideGlucagonGIPHomo sapiensNon-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ23.22022-03-0210.1038/s41467-022-28683-0
7VAB (No Gprot) B1PeptideGlucagonGIPHomo sapiensNon-Acylated Tirzepatide-3.22022-03-0210.1038/s41467-022-28683-0
7FIYB1PeptideGlucagonGIPHomo sapiensTirzepatide-Gs/β1/γ23.42022-03-0210.1038/s41467-022-28683-0
7FIY (No Gprot) B1PeptideGlucagonGIPHomo sapiensTirzepatide-3.42022-03-0210.1038/s41467-022-28683-0
7FINB1PeptideGlucagonGIPHomo sapiensPeptide-20; GGL-Gs/β1/γ23.12022-02-2310.1038/s41467-022-28683-0
7FIN (No Gprot) B1PeptideGlucagonGIPHomo sapiensPeptide-20; GGL-3.12022-02-2310.1038/s41467-022-28683-0
7DTYB1PeptideGlucagonGIPHomo sapiensGIP-Gs/β1/γ22.982021-08-0410.7554/eLife.68719
7DTY (No Gprot) B1PeptideGlucagonGIPHomo sapiensGIP-2.982021-08-0410.7554/eLife.68719




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