psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E125	R:R:N124	2.63	No	No	0	3	1
2	R:R:A126	R:R:N124	4.69	No	No	0	1	1
3	R:R:F127	R:R:N124	12.08	No	No	0	2	1
4	R:R:A126	R:R:Q130	3.03	No	No	0	1	3
5	R:R:F127	R:R:L128	2.44	No	No	0	2	3
6	R:R:F127	R:R:R131	9.62	No	No	0	2	3
7	R:R:L128	R:R:L132	6.92	No	No	0	3	3
8	R:R:Q130	R:R:R131	5.84	No	No	0	3	3
9	R:R:Q130	R:R:R370	7.01	No	Yes	0	3	5
10	R:R:E135	R:R:L132	3.98	No	No	0	3	3
11	R:R:I133	R:R:L134	2.85	No	No	0	4	5
12	R:R:F371	R:R:I133	3.77	No	No	0	4	4
13	R:R:L134	R:R:L137	6.92	No	No	3	5	6
14	R:R:L134	R:R:L374	4.15	No	Yes	3	5	6
15	R:R:L137	R:R:L374	6.92	No	Yes	3	6	6
16	R:R:G375	R:R:L137	1.71	No	No	3	5	6
17	R:R:Q138	R:R:Y141	4.51	No	Yes	0	5	7
18	R:R:Y141	R:R:Y145	19.86	Yes	Yes	2	7	7
19	R:R:I187	R:R:Y141	3.63	No	Yes	2	7	7
20	R:R:I378	R:R:Y141	14.51	No	Yes	0	8	7
21	R:R:S381	R:R:Y141	2.54	Yes	Yes	2	5	7
22	R:R:G144	R:R:V143	1.84	No	Yes	0	8	5
23	R:R:S146	R:R:V143	3.23	No	Yes	0	7	5
24	R:R:G144	R:R:S382	3.71	No	No	0	8	9
25	R:R:I187	R:R:Y145	9.67	No	Yes	2	7	7
26	R:R:L188	R:R:Y145	5.86	No	Yes	0	7	7
27	R:R:S381	R:R:Y145	5.09	Yes	Yes	2	5	7
28	R:R:L147	R:R:T151	2.95	No	Yes	1	5	7
29	R:R:F386	R:R:L147	10.96	Yes	No	1	5	5
30	R:R:L152	R:R:S148	3	Yes	No	0	9	9
31	R:R:A184	R:R:S148	1.71	No	No	0	8	9
32	R:R:A184	R:R:L149	3.15	No	No	0	8	6
33	R:R:F386	R:R:T151	3.89	Yes	Yes	1	5	7
34	R:R:S389	R:R:T151	3.2	No	Yes	1	8	7
35	R:R:T151	R:R:V390	6.35	Yes	Yes	1	7	5
36	R:R:F177	R:R:L152	4.87	Yes	Yes	1	9	9
37	R:R:F180	R:R:L152	3.65	Yes	Yes	1	8	9
38	R:R:L152	R:R:M181	7.07	Yes	No	0	9	7
39	R:R:L152	R:R:S389	9.01	Yes	No	1	9	8
40	R:R:L153	R:R:M181	2.83	No	No	0	3	7
41	R:R:I158	R:R:L154	2.85	No	No	0	8	5
42	R:R:A155	R:R:F177	2.77	No	Yes	1	9	9
43	R:R:A155	R:R:C393	1.81	No	No	1	9	9
44	R:R:F177	R:R:L156	2.44	Yes	No	0	9	6
45	R:R:L156	R:R:M181	4.24	No	No	0	6	7
46	R:R:I158	R:R:L159	2.85	No	No	0	8	8
47	R:R:F162	R:R:I158	8.79	Yes	No	0	7	8
48	R:R:L159	R:R:N170	2.75	No	Yes	0	8	9
49	R:R:I174	R:R:L159	7.14	No	No	0	7	8
50	R:R:F162	R:R:L161	12.18	Yes	No	0	7	3
51	R:R:F162	R:R:V399	2.62	Yes	No	0	7	9
52	R:R:E402	R:R:F162	17.49	No	Yes	0	8	7
53	R:R:F162	R:R:I403	6.28	Yes	No	0	7	5
54	R:R:H166	R:R:R163	6.77	No	No	0	7	8
55	R:R:E402	R:R:R164	13.96	No	No	0	8	7
56	R:R:L165	R:R:N170	5.49	No	Yes	1	9	9
57	R:R:E398	R:R:L165	6.63	Yes	No	1	9	9
58	R:R:L165	R:R:V399	2.98	No	No	0	9	9
59	R:R:H166	R:R:Y171	10.89	No	No	0	7	6
60	R:R:C167	R:R:N170	4.72	No	Yes	0	8	9
61	R:R:T168	R:R:Y240	3.75	No	Yes	1	8	8
62	R:R:E253	R:R:T168	7.06	No	No	1	5	8
63	R:R:F256	R:R:T168	3.89	Yes	No	0	5	8
64	R:R:N170	R:R:R169	2.41	Yes	Yes	1	9	9
65	R:R:H173	R:R:R169	19.18	Yes	Yes	1	9	9
66	R:R:R169	R:R:Y240	4.12	Yes	Yes	1	9	8
67	R:R:N396	R:R:R169	10.85	No	Yes	1	9	9
68	R:R:E398	R:R:R169	3.49	Yes	Yes	1	9	9
69	R:R:E398	R:R:N170	2.63	Yes	Yes	1	9	9
70	R:R:F256	R:R:Y171	8.25	Yes	No	0	5	6
71	R:R:H173	R:R:I172	2.65	Yes	Yes	1	9	9
72	R:R:I172	R:R:W233	4.7	Yes	Yes	1	9	9
73	R:R:I172	R:R:V236	3.07	Yes	Yes	1	9	8
74	R:R:E237	R:R:I172	2.73	Yes	Yes	1	9	9
75	R:R:I172	R:R:Y240	4.84	Yes	Yes	1	9	8
76	R:R:F256	R:R:I172	2.51	Yes	Yes	0	5	9
77	R:R:I172	R:R:Y259	2.42	Yes	Yes	1	9	8
78	R:R:E237	R:R:H173	3.69	Yes	Yes	1	9	9
79	R:R:H173	R:R:Y392	25.04	Yes	No	1	9	8
80	R:R:N175	R:R:W233	13.56	Yes	Yes	1	9	9
81	R:R:F256	R:R:N175	2.42	Yes	Yes	0	5	9
82	R:R:L260	R:R:N175	4.12	No	Yes	1	6	9
83	R:R:N175	R:R:W264	3.39	Yes	Yes	1	9	9
84	R:R:F177	R:R:L176	2.44	Yes	No	0	9	9
85	R:R:F180	R:R:L176	4.87	Yes	No	0	8	9
86	R:R:L176	R:R:L234	2.77	No	No	0	9	9
87	R:R:F177	R:R:S389	2.64	Yes	No	1	9	8
88	R:R:C393	R:R:F177	4.19	No	Yes	1	9	9
89	R:R:T178	R:R:W264	2.43	No	Yes	0	3	9
90	R:R:A229	R:R:S179	3.42	No	No	1	8	9
91	R:R:N230	R:R:S179	7.45	No	No	1	9	9
92	R:R:S179	R:R:W264	4.94	No	Yes	1	9	9
93	R:R:F180	R:R:R183	5.34	Yes	Yes	1	8	8
94	R:R:F180	R:R:N230	25.37	Yes	No	1	8	9
95	R:R:F180	R:R:Q384	4.68	Yes	Yes	1	8	9
96	R:R:F180	R:R:G385	3.01	Yes	No	1	8	9
97	R:R:F180	R:R:V388	3.93	Yes	No	0	8	9
98	R:R:L182	R:R:V222	2.98	No	No	0	7	5
99	R:R:L182	R:R:Y225	2.34	No	Yes	0	7	8
100	R:R:C226	R:R:L182	4.76	No	No	0	6	7
101	R:R:C226	R:R:R183	4.18	No	Yes	1	6	8
102	R:R:R183	R:R:V227	2.62	Yes	No	1	8	6
103	R:R:N230	R:R:R183	8.44	No	Yes	1	9	8
104	R:R:Q384	R:R:R183	7.01	Yes	Yes	1	9	8
105	R:R:A186	R:R:S189	1.71	No	No	0	6	5
106	R:R:A186	R:R:V222	3.39	No	No	0	6	5
107	R:R:I187	R:R:R190	6.26	No	Yes	2	7	6
108	R:R:A219	R:R:S189	1.71	No	No	0	6	5
109	R:R:D191	R:R:R190	5.96	No	Yes	0	7	6
110	R:R:L194	R:R:R190	8.5	Yes	Yes	2	7	6
111	R:R:A219	R:R:R190	2.77	No	Yes	0	6	6
112	R:R:Q220	R:R:R190	8.18	No	Yes	2	5	6
113	R:R:R190	R:R:W287	7	Yes	Yes	2	6	9
114	R:R:A215	R:R:L193	3.15	No	No	0	3	5
115	R:R:L194	R:R:P195	3.28	Yes	No	0	7	3
116	R:R:C216	R:R:L194	3.17	No	Yes	0	9	7
117	R:R:L194	R:R:W287	6.83	Yes	Yes	2	7	9
118	R:R:C216	R:R:C286	7.28	No	No	0	9	9
119	R:R:R217	R:R:R278	10.66	No	No	0	8	8
120	R:R:N283	R:R:R217	2.41	No	No	0	6	8
121	R:R:Q220	R:R:Q224	2.56	No	No	0	5	6
122	R:R:Q220	R:R:W287	20.81	No	Yes	2	5	9
123	R:R:I221	R:R:W274	3.52	No	Yes	5	5	8
124	R:R:I221	R:R:V275	7.68	No	No	5	5	6
125	R:R:Q224	R:R:W274	7.67	No	Yes	0	6	8
126	R:R:I299	R:R:Q224	5.49	No	No	0	7	6
127	R:R:W264	R:R:Y225	7.72	Yes	Yes	0	9	8
128	R:R:P267	R:R:Y225	2.78	Yes	Yes	0	9	8
129	R:R:A268	R:R:Y225	4	No	Yes	0	3	8
130	R:R:C226	R:R:V227	1.71	No	No	1	6	6
131	R:R:G228	R:R:P267	4.06	No	Yes	0	5	9
132	R:R:G228	R:R:I303	1.76	No	No	0	5	7
133	R:R:A229	R:R:W264	3.89	No	Yes	1	8	9
134	R:R:A229	R:R:P267	3.74	No	Yes	0	8	9
135	R:R:L234	R:R:Y231	2.34	No	Yes	0	9	8
136	R:R:I303	R:R:Y231	3.63	No	Yes	0	7	8
137	R:R:G351	R:R:Y231	2.9	No	Yes	0	9	8
138	R:R:V352	R:R:Y231	7.57	Yes	Yes	6	6	8
139	R:R:V355	R:R:Y231	11.36	No	Yes	6	5	8
140	R:R:G263	R:R:T232	3.64	Yes	No	0	9	6
141	R:R:P267	R:R:T232	12.24	Yes	No	0	9	6
142	R:R:V236	R:R:W233	7.36	Yes	Yes	1	8	9
143	R:R:L260	R:R:W233	2.28	No	Yes	1	6	9
144	R:R:G263	R:R:W233	7.04	Yes	Yes	1	9	9
145	R:R:W233	R:R:W264	17.81	Yes	Yes	1	9	9
146	R:R:L234	R:R:P348	4.93	No	No	0	9	9
147	R:R:L235	R:R:V239	2.98	Yes	No	0	8	7
148	R:R:L235	R:R:T306	2.95	Yes	No	0	8	7
149	R:R:I309	R:R:L235	2.85	No	Yes	0	6	8
150	R:R:L235	R:R:N310	8.24	Yes	No	0	8	9
151	R:R:V236	R:R:Y259	3.79	Yes	Yes	1	8	8
152	R:R:G263	R:R:V236	1.84	Yes	Yes	1	9	8
153	R:R:E237	R:R:G238	4.91	Yes	No	0	9	9
154	R:R:E237	R:R:Y392	11.22	Yes	No	1	9	8
155	R:R:L244	R:R:Y240	4.69	No	Yes	0	8	8
156	R:R:E253	R:R:Y240	3.37	No	Yes	1	5	8
157	R:R:Y240	R:R:Y259	7.94	Yes	Yes	1	8	8
158	R:R:I317	R:R:L241	5.71	No	No	0	9	9
159	R:R:H242	R:R:V246	8.3	Yes	No	0	8	7
160	R:R:H242	R:R:I313	2.65	Yes	No	7	8	8
161	R:R:H242	R:R:R316	6.77	Yes	No	0	8	8
162	R:R:H242	R:R:I317	2.65	Yes	No	7	8	9
163	R:R:L247	R:R:S243	3	No	No	0	5	7
164	R:R:S243	R:R:Y259	2.54	No	Yes	0	7	8
165	R:R:I320	R:R:L245	5.71	No	No	0	8	8
166	R:R:E252	R:R:L247	5.3	No	No	0	7	5
167	R:R:G249	R:R:G250	2.11	No	No	0	7	6
168	R:R:G250	R:R:S251	1.86	No	No	0	6	7
169	R:R:H255	R:R:Y258	4.36	No	No	0	4	3
170	R:R:H255	R:R:Y259	3.27	No	Yes	0	4	8
171	R:R:R257	R:R:Y258	5.14	No	No	0	3	3
172	R:R:L260	R:R:W264	3.42	No	Yes	1	6	9
173	R:R:G263	R:R:L262	3.42	Yes	No	0	9	6
174	R:R:G265	R:R:P267	2.03	No	Yes	0	6	9
175	R:R:A266	R:R:P267	3.74	No	Yes	0	4	9
176	R:R:F270	R:R:L269	6.09	No	No	0	5	4
177	R:R:F270	R:R:P302	14.45	No	No	0	5	9
178	R:R:V271	R:R:W274	2.45	No	Yes	0	6	8
179	R:R:I272	R:R:P273	3.39	No	No	0	2	4
180	R:R:V275	R:R:W274	4.9	No	Yes	5	6	8
181	R:R:R278	R:R:W274	5	No	Yes	0	8	8
182	R:R:I298	R:R:W274	5.87	No	Yes	0	8	8
183	R:R:I276	R:R:L280	2.85	No	No	0	3	3
184	R:R:R278	R:R:T284	7.76	No	No	0	8	4
185	R:R:L280	R:R:Y279	4.69	No	No	0	3	3
186	R:R:N283	R:R:Y279	2.33	No	No	0	6	3
187	R:R:L280	R:R:Y281	5.86	No	No	0	3	3
188	R:R:E282	R:R:E291	16.49	No	No	0	5	4
189	R:R:E282	R:R:I295	9.56	No	No	0	5	3
190	R:R:C286	R:R:W287	3.92	No	Yes	0	9	9
191	R:R:I295	R:R:N290	7.08	No	No	0	3	6
192	R:R:K293	R:R:V292	3.04	No	No	0	5	6
193	R:R:A294	R:R:V292	3.39	No	No	0	3	6
194	R:R:K293	R:R:W297	10.44	No	No	0	5	7
195	R:R:W296	R:R:W297	9.37	No	No	0	6	7
196	R:R:R300	R:R:W296	24.99	No	No	0	7	6
197	R:R:L304	R:R:R300	23.08	No	No	0	4	7
198	R:R:R300	R:R:V356	9.15	No	No	0	7	6
199	R:R:P302	R:R:T301	3.5	No	No	0	9	4
200	R:R:I307	R:R:N310	2.83	No	No	0	7	9
201	R:R:I307	R:R:L349	4.28	No	No	0	7	9
202	R:R:I307	R:R:V352	16.9	No	Yes	0	7	6
203	R:R:L308	R:R:L312	4.15	No	No	0	3	4
204	R:R:I309	R:R:I313	2.94	No	No	0	6	8
205	R:R:F311	R:R:I315	12.56	No	No	0	6	5
206	R:R:F311	R:R:L349	2.44	No	No	0	6	9
207	R:R:I313	R:R:I317	2.94	No	No	7	8	9
208	R:R:F314	R:R:F345	5.36	No	No	0	9	8
209	R:R:F314	R:R:L346	8.53	No	No	0	9	9
210	R:R:L318	R:R:S342	4.5	No	No	0	7	9
211	R:R:G319	R:R:L322	1.71	No	No	0	8	5
212	R:R:L321	R:R:L325	5.54	No	Yes	0	9	7
213	R:R:L322	R:R:R338	6.07	No	No	0	5	9
214	R:R:K324	R:R:S323	3.06	No	No	0	9	7
215	R:R:D334	R:R:L325	8.14	Yes	Yes	0	6	7
216	R:R:Q329	R:R:R326	2.34	No	No	0	7	7
217	R:R:M330	R:R:R328	7.44	No	No	0	5	6
218	R:R:D334	R:R:M330	6.93	Yes	No	0	6	5
219	R:R:R331	R:R:R333	6.4	No	No	0	5	6
220	R:R:C332	R:R:R336	4.18	No	No	0	6	6
221	R:R:R336	R:R:Y335	4.12	No	No	0	6	5
222	R:R:L337	R:R:R341	6.07	No	No	0	7	9
223	R:R:L339	R:R:S342	4.5	No	No	8	9	9
224	R:R:L339	R:R:T343	4.42	No	No	8	9	9
225	R:R:A340	R:R:R341	4.15	No	No	0	8	9
226	R:R:S342	R:R:T343	3.2	No	No	8	9	9
227	R:R:L346	R:R:L349	2.77	No	No	0	9	9
228	R:R:P348	R:R:V347	3.53	No	No	0	9	8
229	R:R:Q384	R:R:V347	2.87	Yes	No	0	9	8
230	R:R:L387	R:R:V347	10.43	No	No	0	6	8
231	R:R:L350	R:R:L380	9.69	No	No	0	9	7
232	R:R:V352	R:R:V355	3.21	Yes	No	6	6	5
233	R:R:E354	R:R:E377	19.03	No	No	0	7	7
234	R:R:E354	R:R:L380	3.98	No	No	0	7	7
235	R:R:E354	R:R:S381	8.62	No	Yes	0	7	5
236	R:R:F357	R:R:K373	7.44	No	No	0	7	7
237	R:R:E377	R:R:F357	7	No	No	0	7	7
238	R:R:A358	R:R:P359	1.87	No	No	0	6	5
239	R:R:E363	R:R:L374	3.98	No	Yes	0	5	6
240	R:R:R366	R:R:R370	2.13	No	Yes	0	5	5
241	R:R:G367	R:R:R370	4.5	No	Yes	0	4	5
242	R:R:A368	R:R:F371	4.16	No	No	0	1	4
243	R:R:F371	R:R:R370	4.28	No	Yes	0	4	5
244	R:R:G375	R:R:L374	1.71	No	Yes	3	5	6
245	R:R:F376	R:R:L380	2.44	No	No	0	4	7
246	R:R:F379	R:R:F383	11.79	No	No	0	6	6
247	R:R:F383	R:R:F386	7.5	No	Yes	0	6	5
248	R:R:F383	R:R:L387	9.74	No	No	0	6	6
249	R:R:G385	R:R:Q384	6.58	No	Yes	1	9	9
250	R:R:F386	R:R:V390	9.18	Yes	Yes	1	5	5
251	R:R:L391	R:R:V390	4.47	Yes	Yes	1	7	5
252	R:R:F394	R:R:V390	5.24	Yes	Yes	1	8	5
253	R:R:F394	R:R:L391	4.87	Yes	Yes	1	8	7
254	R:R:I395	R:R:L391	5.71	No	Yes	1	5	7
255	R:R:F394	R:R:I395	10.05	Yes	No	1	8	5
256	R:R:F394	R:R:Q400	2.34	Yes	No	0	8	8
257	R:R:E398	R:R:N396	13.15	Yes	No	1	9	9
258	R:R:N396	R:R:V399	7.39	No	No	0	9	9
259	R:R:K397	R:R:Q400	5.42	No	No	0	5	8
260	R:R:R405	R:R:S401	3.95	Yes	No	0	8	4
261	R:R:I403	R:R:R404	6.26	No	No	0	5	6
262	R:R:H408	R:R:R404	2.26	No	No	0	4	6
263	R:R:H409	R:R:R405	11.28	No	Yes	0	7	8
264	R:R:H408	R:R:W407	7.41	No	No	0	4	5
265	R:R:R411	R:R:W407	2	No	No	9	4	5
266	R:R:R414	R:R:W407	2	No	No	9	5	5
267	R:R:C410	R:R:R414	4.18	No	No	0	4	5
268	R:R:R411	R:R:R414	2.13	No	No	9	4	5
269	R:R:A186	R:R:T223	1.68	No	No	0	6	6
270	R:R:E252	R:R:G250	1.64	No	No	0	7	6
271	R:R:S381	R:R:S382	1.63	Yes	No	0	5	9
272	R:R:A294	R:R:I295	1.62	No	No	0	3	3
273	R:R:V139	R:R:V143	1.6	No	Yes	4	3	5
274	R:R:V352	R:R:V356	1.6	Yes	No	0	6	6
275	R:R:T142	R:R:V139	1.59	No	No	4	7	3
276	R:R:T142	R:R:V143	1.59	No	Yes	4	7	5
277	R:R:T218	R:R:V222	1.59	No	No	0	3	5
278	R:R:A372	R:R:L369	1.58	No	No	0	5	4
279	R:R:I320	R:R:V246	1.54	No	No	0	8	7
280	R:R:I378	R:R:V360	1.54	No	No	0	8	4
281	R:R:C286	R:R:Q285	1.53	No	No	0	9	3
282	R:R:K324	R:R:T327	1.5	No	No	0	9	6
283	R:R:G406	R:R:R405	1.5	No	Yes	0	5	8
284	R:R:I272	R:R:I276	1.47	No	No	0	2	3
285	R:R:I309	R:R:M305	1.46	No	No	0	6	4
286	R:R:I320	R:R:K324	1.45	No	No	0	8	9
287	R:R:I315	R:R:L312	1.43	No	No	0	5	4
288	R:R:I378	R:R:L374	1.43	No	Yes	0	8	6
289	R:R:E288	R:R:T284	1.41	No	No	0	6	4
290	R:R:E363	R:R:T361	1.41	No	No	0	5	7
291	R:R:D129	R:R:I133	1.4	No	No	0	1	4
292	R:R:L153	R:R:L157	1.38	No	No	0	3	1
293	R:R:L318	R:R:L321	1.38	No	No	0	7	9
294	R:R:L325	R:R:L337	1.38	Yes	No	0	7	7
295	R:R:L344	R:R:L391	1.38	No	Yes	0	8	7
296	R:R:A365	R:R:R370	1.38	No	Yes	0	6	5
297	R:R:L213	R:R:N210	1.37	No	No	0	4	4
298	R:R:R411	R:R:S415	1.32	No	No	0	4	5
299	R:R:R136	R:R:V139	1.31	No	No	0	4	3
300	R:R:H353	R:R:K373	1.31	No	No	0	8	7
301	R:R:R328	R:R:T327	1.29	No	No	0	6	6
302	R:R:E362	R:R:Q364	1.27	No	No	0	5	5
303	R:R:V277	R:R:Y281	1.26	No	No	0	5	3
304	R:R:L193	R:R:R192	1.21	No	No	0	5	4
305	R:R:T301	R:R:W297	1.21	No	No	0	4	7
306	R:R:L325	R:R:R338	1.21	Yes	No	0	7	9
307	R:R:D334	R:R:R331	1.19	Yes	No	0	6	5
308	R:R:D334	R:R:Y335	1.15	Yes	No	0	6	5
309	R:R:R164	R:R:R405	1.07	No	Yes	0	7	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y141	9.01	5	2	7
2	R:R:V143	2.065	4	4	5
3	R:R:Y145	10.12	4	2	7
4	R:R:T151	4.0975	4	1	7
5	R:R:L152	5.52	5	1	9
6	R:R:F162	9.472	5	0	7
7	R:R:R169	8.01	5	1	9
8	R:R:N170	3.6	5	1	9
9	R:R:I172	3.27429	7	1	9
10	R:R:H173	12.64	4	1	9
11	R:R:N175	5.8725	4	1	9
12	R:R:F177	3.225	6	1	9
13	R:R:F180	7.26429	7	1	8
14	R:R:R183	5.518	5	1	8
15	R:R:R190	6.445	6	2	6
16	R:R:L194	5.445	4	2	7
17	R:R:Y225	4.21	4	0	8
18	R:R:Y231	5.56	5	6	8
19	R:R:W233	8.79167	6	1	9
20	R:R:L235	4.255	4	0	8
21	R:R:V236	4.015	4	1	8
22	R:R:E237	5.6375	4	1	9
23	R:R:Y240	4.785	6	1	8
24	R:R:H242	5.0925	4	7	8
25	R:R:F256	4.2675	4	0	5
26	R:R:Y259	3.992	5	1	8
27	R:R:G263	3.985	4	1	9
28	R:R:W264	6.22857	7	1	9
29	R:R:P267	4.765	6	0	9
30	R:R:W274	4.90167	6	5	8
31	R:R:W287	9.64	4	2	9
32	R:R:L325	4.0675	4	0	7
33	R:R:D334	4.3525	4	0	6
34	R:R:V352	7.32	4	6	6
35	R:R:R370	3.86	5	0	5
36	R:R:L374	3.638	5	3	6
37	R:R:S381	4.47	4	2	5
38	R:R:Q384	5.285	4	1	9
39	R:R:F386	7.8825	4	1	5
40	R:R:V390	6.31	4	1	5
41	R:R:L391	4.1075	4	1	7
42	R:R:F394	5.625	4	1	8
43	R:R:E398	6.475	4	1	9
44	R:R:R405	4.45	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F371	R:R:R370	12.4153	4.28	No	Yes	0	4	5
2	R:R:F371	R:R:I133	14.2249	3.77	No	No	0	4	4
3	R:R:I133	R:R:L134	16.0149	2.85	No	No	0	4	5
4	R:R:L134	R:R:L374	16.725	4.15	No	Yes	3	5	6
5	R:R:I378	R:R:L374	21.0347	1.43	No	Yes	0	8	6
6	R:R:I378	R:R:Y141	22.6742	14.51	No	Yes	0	8	7
7	R:R:I187	R:R:Y141	36.2937	3.63	No	Yes	2	7	7
8	R:R:S381	R:R:Y141	14.971	2.54	Yes	Yes	2	5	7
9	R:R:S381	R:R:S382	12.7327	1.63	Yes	No	0	5	9
10	R:R:G144	R:R:S382	10.9329	3.71	No	No	0	8	9
11	R:R:I187	R:R:R190	52.1941	6.26	No	Yes	2	7	6
12	R:R:A219	R:R:R190	67.5513	2.77	No	Yes	0	6	6
13	R:R:A219	R:R:S189	68.0061	1.71	No	No	0	6	5
14	R:R:A186	R:R:S189	68.4545	1.71	No	No	0	6	5
15	R:R:A186	R:R:V222	69.3315	3.39	No	No	0	6	5
16	R:R:L182	R:R:V222	70.1823	2.98	No	No	0	7	5
17	R:R:C226	R:R:L182	15.3408	4.76	No	No	0	6	7
18	R:R:C226	R:R:R183	14.3493	4.18	No	Yes	1	6	8
19	R:R:F180	R:R:R183	11.6463	5.34	Yes	Yes	1	8	8
20	R:R:F180	R:R:L152	18.5183	3.65	Yes	Yes	1	8	9
21	R:R:S389	R:R:T151	10.7006	3.2	No	Yes	1	8	7
22	R:R:L182	R:R:Y225	57.4004	2.34	No	Yes	0	7	8
23	R:R:W264	R:R:Y225	51.0553	7.72	Yes	Yes	0	9	8
24	R:R:W233	R:R:W264	75.2053	17.81	Yes	Yes	1	9	9
25	R:R:I172	R:R:W233	84.1978	4.7	Yes	Yes	1	9	9
26	R:R:H173	R:R:I172	44.4615	2.65	Yes	Yes	1	9	9
27	R:R:H173	R:R:R169	41.7847	19.18	Yes	Yes	1	9	9
28	R:R:N170	R:R:R169	23.0767	2.41	Yes	Yes	1	9	9
29	R:R:L159	R:R:N170	13.3545	2.75	No	Yes	0	8	9
30	R:R:I172	R:R:Y240	45.921	4.84	Yes	Yes	1	9	8
31	R:R:R169	R:R:Y240	50.0115	4.12	Yes	Yes	1	9	8
32	R:R:N396	R:R:R169	59.0464	10.85	No	Yes	1	9	9
33	R:R:N396	R:R:V399	55.9933	7.39	No	No	0	9	9
34	R:R:F162	R:R:V399	52.9697	2.62	Yes	No	0	7	9
35	R:R:E402	R:R:F162	20.2199	17.49	No	Yes	0	8	7
36	R:R:F162	R:R:I403	26.7646	6.28	Yes	No	0	7	5
37	R:R:E402	R:R:R164	16.8657	13.96	No	No	0	8	7
38	R:R:V236	R:R:Y259	15.223	3.79	Yes	Yes	1	8	8
39	R:R:L176	R:R:L234	10.8217	2.77	No	No	0	9	9
40	R:R:A229	R:R:W264	18.2369	3.89	No	Yes	1	8	9
41	R:R:A229	R:R:P267	19.0222	3.74	No	Yes	0	8	9
42	R:R:P267	R:R:Y225	41.9844	2.78	Yes	Yes	0	9	8
43	R:R:S179	R:R:W264	16.6858	4.94	No	Yes	1	9	9
44	R:R:Q220	R:R:R190	19.4345	8.18	No	Yes	2	5	6
45	R:R:Q220	R:R:Q224	18.96	2.56	No	No	0	5	6
46	R:R:Q224	R:R:W274	17.0752	7.67	No	Yes	0	6	8
47	R:R:R278	R:R:W274	12.2452	5	No	Yes	0	8	8
48	R:R:G228	R:R:P267	96.0601	4.06	No	Yes	0	5	9
49	R:R:G228	R:R:I303	94.9573	1.76	No	No	0	5	7
50	R:R:I303	R:R:Y231	93.9069	3.63	No	Yes	0	7	8
51	R:R:V352	R:R:Y231	100	7.57	Yes	Yes	6	6	8
52	R:R:G263	R:R:W233	17.0195	7.04	Yes	Yes	1	9	9
53	R:R:P267	R:R:T232	42.0105	12.24	Yes	No	0	9	6
54	R:R:G263	R:R:T232	41.8731	3.64	Yes	No	0	9	6
55	R:R:I307	R:R:V352	75.6177	16.9	No	Yes	0	7	6
56	R:R:I307	R:R:N310	61.9523	2.83	No	No	0	7	9
57	R:R:L235	R:R:N310	60.3881	8.24	Yes	No	0	8	9
58	R:R:I309	R:R:L235	55.6563	2.85	No	Yes	0	6	8
59	R:R:I309	R:R:I313	52.469	2.94	No	No	0	6	8
60	R:R:H242	R:R:I313	47.5245	2.65	Yes	No	7	8	8
61	R:R:H242	R:R:V246	44.4517	8.3	Yes	No	0	8	7
62	R:R:I320	R:R:V246	42.809	1.54	No	No	0	8	7
63	R:R:V352	R:R:V356	28.0081	1.6	Yes	No	0	6	6
64	R:R:R300	R:R:V356	26.3065	9.15	No	No	0	7	6
65	R:R:R300	R:R:W296	22.8836	24.99	No	No	0	7	6
66	R:R:W296	R:R:W297	21.1623	9.37	No	No	0	6	7
67	R:R:K293	R:R:W297	12.4579	10.44	No	No	0	5	7
68	R:R:K293	R:R:V292	10.6973	3.04	No	No	0	5	6
69	R:R:I307	R:R:L349	14.094	4.28	No	No	0	7	9
70	R:R:I320	R:R:K324	39.625	1.45	No	No	0	8	9
71	R:R:K324	R:R:T327	36.3068	1.5	No	No	0	9	6
72	R:R:R328	R:R:T327	34.6379	1.29	No	No	0	6	6
73	R:R:M330	R:R:R328	32.9625	7.44	No	No	0	5	6
74	R:R:D334	R:R:M330	31.2805	6.93	Yes	No	0	6	5
75	R:R:D334	R:R:L325	21.0511	8.14	Yes	Yes	0	6	7
76	R:R:E354	R:R:S381	14.526	8.62	No	Yes	0	7	5
77	R:R:R164	R:R:R405	13.505	1.07	No	Yes	0	7	8
78	R:R:I403	R:R:R404	23.5675	6.26	No	No	0	5	6
79	R:R:H408	R:R:R404	20.2199	2.26	No	No	0	4	6
80	R:R:H408	R:R:W407	16.8657	7.41	No	No	0	4	5
81	R:R:S381	R:R:Y145	13.6621	5.09	Yes	Yes	2	5	7
82	R:R:I187	R:R:Y145	15.2525	9.67	No	Yes	2	7	7
83	R:R:N230	R:R:S179	17.2061	7.45	No	No	1	9	9
84	R:R:F180	R:R:N230	14.4704	25.37	Yes	No	1	8	9
85	R:R:L234	R:R:Y231	11.5547	2.34	No	Yes	0	9	8
86	R:R:I172	R:R:V236	15.9593	3.07	Yes	Yes	1	9	8
87	R:R:G263	R:R:V236	25.9433	1.84	Yes	Yes	1	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8ITL_nogp

PDB Summary
PDB	8ITL_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.71
Number of Linked Nodes	265
Number of Links	309
Number of Hubs	44
Number of Links mediated by Hubs	164
Number of Communities	9
Number of Nodes involved in Communities	70
Number of Links involved in Communities	98

Path Summary
Number Of Nodes in MetaPath	88
Number Of Links MetaPath	87
Number of Shortest Paths	64317
Length Of Smallest Path	3
Average Path Length	18.1358
Length of Longest Path	44
Minimum Path Strength	1.17
Average Path Strength	5.7196
Maximum Path Strength	24.035
Minimum Path Correlation	0.7
Average Path Correlation	0.940133
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.85714
Average % Of Corr. Nodes	44.4954
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.4816
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P48546
Sequence	>8ITL_nogp_Chain_R N E A F L D Q R L I L E R L Q V M Y T V G Y S L S L A T L L L A L L I L S L F R R L H C T R N Y I H I N L F T S F M L R A A A I L S R D R L L P N Q A L A A C R T A Q I V T Q Y C V G A N Y T W L L V E G V Y L H S L L V L V G G S E E G H F R Y Y L L L G W G A P A L F V I P W V I V R Y L Y E N T Q C W E R N E V K A I W W I I R T P I L M T I L I N F L I F I R I L G I L L S K L R T R Q M R C R D Y R L R L A R S T L F L V P L L G V H E V V F A P V T E E Q A R G A L R F A K L G F E I F L S S F Q G F L V S V L Y C F I N K E V Q S E I R R G W H H C R L R R S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7RBT	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	LSN3556672	chim(NtGi1-Gs)/β1/γ2	3.08	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RBT (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	LSN3556672		3.08	2022-04-13	doi.org/10.1073/pnas.2116506119
	8WA3	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	2.86	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		2.86	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	7FIN	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-	Gs/β1/γ2	3.1	2022-02-23	doi.org/10.1038/s41467-022-28683-0
	7FIN (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-		3.1	2022-02-23	doi.org/10.1038/s41467-022-28683-0
	7FIY	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VAB	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VAB (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-		3.2	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7RA3	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	chim(NtGi1-Gs)/β1/γ2	3.24	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		3.24	2022-04-13	doi.org/10.1073/pnas.2116506119
	8ITL	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.23	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITL (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.23	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITM	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.13	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITM (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.13	2023-10-18	doi.org/10.1073/pnas.2306145120
	7DTY	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	Gs/β1/γ2	2.98	2021-08-04	doi.org/10.7554/eLife.68719
	7DTY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		2.98	2021-08-04	doi.org/10.7554/eLife.68719
	8YW4	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ2	3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW4 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-		3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8ITL_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.