psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D129	R:R:L132	4.07	No	No	0	1	3
2	R:R:D129	R:R:I133	4.2	No	No	0	1	4
3	R:R:Q130	R:R:R131	7.01	No	Yes	4	3	3
4	R:R:Q130	R:R:Q364	7.68	No	No	4	3	5
5	R:R:E363	R:R:R131	4.65	No	Yes	0	5	3
6	R:R:Q364	R:R:R131	5.84	No	Yes	4	5	3
7	R:R:L137	R:R:Q138	3.99	No	No	0	6	5
8	R:R:L137	R:R:L374	4.15	No	No	0	6	6
9	R:R:I378	R:R:L137	4.28	No	No	0	8	6
10	R:R:Y141	R:R:Y145	17.87	Yes	Yes	5	7	7
11	R:R:P359	R:R:Y141	4.17	No	Yes	0	5	7
12	R:R:I378	R:R:Y141	3.63	No	Yes	0	8	7
13	R:R:S381	R:R:Y141	3.82	No	Yes	5	5	7
14	R:R:S146	R:R:V143	4.85	No	No	0	7	5
15	R:R:I187	R:R:Y145	4.84	No	Yes	0	7	7
16	R:R:S381	R:R:Y145	10.17	No	Yes	5	5	7
17	R:R:A184	R:R:L149	4.73	No	No	0	8	6
18	R:R:F386	R:R:T151	5.19	No	No	0	5	7
19	R:R:S389	R:R:T151	6.4	No	No	0	8	7
20	R:R:F177	R:R:L152	3.65	Yes	No	0	9	9
21	R:R:F180	R:R:L152	4.87	Yes	No	0	8	9
22	R:R:L152	R:R:M181	5.65	No	No	0	9	7
23	R:R:L153	R:R:M181	4.24	No	No	0	3	7
24	R:R:I158	R:R:L154	4.28	No	No	6	8	5
25	R:R:F394	R:R:L154	6.09	Yes	No	6	8	5
26	R:R:A155	R:R:F177	4.16	No	Yes	0	9	9
27	R:R:F177	R:R:L156	4.87	Yes	No	0	9	6
28	R:R:F394	R:R:I158	3.77	Yes	No	6	8	8
29	R:R:L159	R:R:N170	4.12	No	No	0	8	9
30	R:R:I174	R:R:L159	4.28	No	No	0	7	8
31	R:R:C393	R:R:L159	4.76	No	No	0	9	8
32	R:R:E402	R:R:F162	9.33	Yes	No	0	8	7
33	R:R:L165	R:R:R164	6.07	No	No	0	9	7
34	R:R:E402	R:R:R164	15.12	Yes	No	0	8	7
35	R:R:L165	R:R:N170	5.49	No	No	0	9	9
36	R:R:E398	R:R:L165	3.98	Yes	No	0	9	9
37	R:R:H166	R:R:Y171	10.89	No	No	0	7	6
38	R:R:C167	R:R:R169	5.57	No	Yes	0	8	9
39	R:R:C167	R:R:N170	4.72	No	No	0	8	9
40	R:R:T168	R:R:Y240	11.24	No	Yes	0	8	8
41	R:R:E253	R:R:T168	7.06	No	No	0	5	8
42	R:R:F256	R:R:T168	5.19	No	No	0	5	8
43	R:R:H173	R:R:R169	5.64	No	Yes	1	9	9
44	R:R:N396	R:R:R169	6.03	No	Yes	1	9	9
45	R:R:E398	R:R:R169	4.65	Yes	Yes	1	9	9
46	R:R:F256	R:R:Y171	6.19	No	No	0	5	6
47	R:R:I172	R:R:W233	4.7	No	Yes	0	9	9
48	R:R:E237	R:R:I172	5.47	No	No	0	9	9
49	R:R:I172	R:R:Y240	6.04	No	Yes	0	9	8
50	R:R:E237	R:R:H173	11.08	No	No	1	9	9
51	R:R:H173	R:R:Y392	9.8	No	Yes	1	9	8
52	R:R:N175	R:R:W233	16.95	No	Yes	7	9	9
53	R:R:N175	R:R:W264	9.04	No	Yes	7	9	9
54	R:R:F180	R:R:L176	6.09	Yes	No	0	8	9
55	R:R:C393	R:R:F177	5.59	No	Yes	0	9	9
56	R:R:N230	R:R:S179	8.94	No	No	0	9	9
57	R:R:F180	R:R:N230	14.5	Yes	No	0	8	9
58	R:R:F180	R:R:V388	9.18	Yes	No	0	8	9
59	R:R:C226	R:R:R183	4.18	No	Yes	0	6	8
60	R:R:R183	R:R:V227	9.15	Yes	No	0	8	6
61	R:R:N230	R:R:R183	8.44	No	Yes	0	9	8
62	R:R:R183	R:R:V355	3.92	Yes	Yes	0	8	5
63	R:R:I187	R:R:T223	6.08	No	No	0	7	6
64	R:R:L194	R:R:R190	4.86	No	Yes	3	7	6
65	R:R:Q220	R:R:R190	5.84	No	Yes	3	5	6
66	R:R:R190	R:R:W287	5	Yes	Yes	3	6	9
67	R:R:L194	R:R:P195	4.93	No	No	0	7	3
68	R:R:L194	R:R:W287	7.97	No	Yes	3	7	9
69	R:R:A212	R:R:N210	4.69	No	No	0	6	4
70	R:R:C216	R:R:C286	7.28	No	No	0	9	9
71	R:R:R217	R:R:R278	12.79	No	Yes	0	8	8
72	R:R:Q220	R:R:Q224	7.68	No	No	0	5	6
73	R:R:Q220	R:R:W287	6.57	No	Yes	3	5	9
74	R:R:I221	R:R:V275	6.14	No	No	0	5	6
75	R:R:Q224	R:R:W274	9.86	No	Yes	0	6	8
76	R:R:W264	R:R:Y225	5.79	Yes	No	0	9	8
77	R:R:P267	R:R:Y225	4.17	Yes	No	0	9	8
78	R:R:A229	R:R:P267	3.74	No	Yes	0	8	9
79	R:R:I303	R:R:Y231	8.46	No	No	0	7	8
80	R:R:V355	R:R:Y231	7.57	Yes	No	0	5	8
81	R:R:P267	R:R:T232	5.25	Yes	No	0	9	6
82	R:R:V236	R:R:W233	6.13	No	Yes	0	8	9
83	R:R:G263	R:R:W233	9.85	No	Yes	0	9	9
84	R:R:W233	R:R:W264	18.74	Yes	Yes	7	9	9
85	R:R:V236	R:R:Y259	3.79	No	Yes	0	8	8
86	R:R:L262	R:R:V236	4.47	No	No	0	6	8
87	R:R:E237	R:R:Y392	15.71	No	Yes	1	9	8
88	R:R:L244	R:R:Y240	4.69	No	Yes	0	8	8
89	R:R:Y240	R:R:Y259	6.95	Yes	Yes	0	8	8
90	R:R:I317	R:R:L241	7.14	No	No	0	9	9
91	R:R:H242	R:R:V246	12.45	Yes	No	0	8	7
92	R:R:H242	R:R:R316	9.03	Yes	No	0	8	8
93	R:R:G250	R:R:S251	3.71	No	No	0	6	7
94	R:R:E252	R:R:G250	6.55	No	No	0	7	6
95	R:R:F270	R:R:P302	11.56	No	No	0	5	9
96	R:R:V275	R:R:W274	3.68	No	Yes	0	6	8
97	R:R:R278	R:R:W274	5	Yes	Yes	0	8	8
98	R:R:I295	R:R:W274	5.87	Yes	Yes	0	3	8
99	R:R:I299	R:R:W274	11.74	No	Yes	0	7	8
100	R:R:E282	R:R:R278	11.63	Yes	Yes	0	5	8
101	R:R:R278	R:R:T284	7.76	Yes	No	0	8	4
102	R:R:R278	R:R:R289	4.26	Yes	No	0	8	4
103	R:R:N283	R:R:Y279	4.65	No	No	0	6	3
104	R:R:L280	R:R:Y281	12.89	No	No	0	3	3
105	R:R:E282	R:R:E291	6.34	Yes	No	2	5	4
106	R:R:E282	R:R:V292	8.56	Yes	No	2	5	6
107	R:R:E282	R:R:I295	9.56	Yes	Yes	2	5	3
108	R:R:E288	R:R:T284	4.23	No	No	2	6	4
109	R:R:E291	R:R:T284	5.64	No	No	2	4	4
110	R:R:C286	R:R:Q285	4.58	No	No	0	9	3
111	R:R:C286	R:R:W287	7.84	No	Yes	0	9	9
112	R:R:E288	R:R:E291	6.34	No	No	2	6	4
113	R:R:R289	R:R:W296	5	No	No	0	4	6
114	R:R:I299	R:R:R289	3.76	No	No	0	7	4
115	R:R:I295	R:R:V292	6.14	Yes	No	2	3	6
116	R:R:K293	R:R:W297	8.12	No	No	0	5	7
117	R:R:W296	R:R:W297	14.99	No	No	0	6	7
118	R:R:R300	R:R:W296	13.99	Yes	No	0	7	6
119	R:R:L304	R:R:R300	3.64	No	Yes	0	4	7
120	R:R:R300	R:R:V355	6.54	Yes	Yes	0	7	5
121	R:R:I307	R:R:V352	6.14	No	No	0	7	6
122	R:R:L349	R:R:N310	6.87	No	No	0	9	9
123	R:R:F311	R:R:I315	7.54	No	No	0	6	5
124	R:R:F314	R:R:L318	8.53	No	Yes	0	9	7
125	R:R:F314	R:R:F345	4.29	No	Yes	0	9	8
126	R:R:F314	R:R:L346	9.74	No	No	0	9	9
127	R:R:L321	R:R:L325	6.92	No	No	0	9	7
128	R:R:L322	R:R:R338	7.29	No	No	0	5	9
129	R:R:R326	R:R:Y335	9.26	No	No	0	7	5
130	R:R:M330	R:R:R328	4.96	No	No	0	5	6
131	R:R:D334	R:R:M330	13.86	No	No	0	6	5
132	R:R:R331	R:R:R333	5.33	No	No	0	5	6
133	R:R:L337	R:R:R341	3.64	No	Yes	0	7	9
134	R:R:A340	R:R:R341	4.15	No	Yes	0	8	9
135	R:R:L344	R:R:R341	3.64	No	Yes	0	8	9
136	R:R:F345	R:R:L391	4.87	Yes	No	1	8	7
137	R:R:F345	R:R:Y392	7.22	Yes	Yes	1	8	8
138	R:R:L346	R:R:L349	4.15	No	No	0	9	9
139	R:R:L387	R:R:V347	4.47	No	No	0	6	8
140	R:R:P348	R:R:Q384	4.74	No	No	0	9	9
141	R:R:G351	R:R:Q384	4.93	No	No	0	9	9
142	R:R:E354	R:R:V355	5.7	No	Yes	0	7	5
143	R:R:E354	R:R:L380	7.95	No	No	0	7	7
144	R:R:E354	R:R:S381	7.19	No	No	0	7	5
145	R:R:F357	R:R:K373	6.2	No	No	8	7	7
146	R:R:E377	R:R:F357	7	No	No	8	7	7
147	R:R:L374	R:R:T361	4.42	No	No	0	6	7
148	R:R:L369	R:R:R370	12.15	No	No	0	4	5
149	R:R:E377	R:R:K373	5.4	No	No	8	7	7
150	R:R:F376	R:R:L380	4.87	No	No	0	4	7
151	R:R:F379	R:R:L380	7.31	No	No	0	6	7
152	R:R:F379	R:R:F383	17.15	No	Yes	0	6	6
153	R:R:F383	R:R:S382	7.93	Yes	No	0	6	9
154	R:R:F383	R:R:F386	16.08	Yes	No	0	6	5
155	R:R:F383	R:R:L387	6.09	Yes	No	0	6	6
156	R:R:V388	R:R:Y392	3.79	No	Yes	0	9	8
157	R:R:F394	R:R:V390	5.24	Yes	No	0	8	5
158	R:R:L391	R:R:Y392	9.38	No	Yes	1	7	8
159	R:R:C393	R:R:F394	5.59	No	Yes	0	9	8
160	R:R:E398	R:R:N396	10.52	Yes	No	1	9	9
161	R:R:N396	R:R:V399	4.43	No	No	0	9	9
162	R:R:K397	R:R:Q400	6.78	No	No	0	5	8
163	R:R:E402	R:R:R405	10.47	Yes	No	0	8	8
164	R:R:H409	R:R:R405	12.41	No	No	0	7	8
165	R:R:H408	R:R:W407	5.29	No	No	0	4	5
166	R:R:R411	R:R:W407	8	No	No	0	4	5
167	R:R:C410	R:R:R414	11.14	No	No	0	4	5
168	R:R:R411	R:R:R414	9.6	No	No	0	4	5
169	R:R:D334	R:R:R331	3.57	No	No	0	6	5
170	R:R:P348	R:R:V347	3.53	No	No	0	9	8
171	R:R:G375	R:R:I378	3.53	No	No	0	5	8
172	R:R:L188	R:R:Y145	3.52	No	Yes	0	7	7
173	R:R:I298	R:R:W274	3.52	No	Yes	0	8	8
174	R:R:P302	R:R:T301	3.5	No	No	0	9	4
175	R:R:A186	R:R:V222	3.39	No	No	0	6	5
176	R:R:I272	R:R:P273	3.39	No	No	0	2	4
177	R:R:A186	R:R:T223	3.36	No	No	0	6	6
178	R:R:R333	R:R:R336	3.2	No	No	0	6	6
179	R:R:S342	R:R:T343	3.2	No	No	0	9	9
180	R:R:C216	R:R:L193	3.17	No	No	0	9	5
181	R:R:A215	R:R:L193	3.15	No	No	0	3	5
182	R:R:L247	R:R:S243	3	No	No	0	5	7
183	R:R:L318	R:R:S342	3	Yes	No	0	7	9
184	R:R:L339	R:R:S342	3	No	No	0	9	9
185	R:R:G367	R:R:R370	3	No	No	0	4	5
186	R:R:L235	R:R:V239	2.98	Yes	No	0	8	7
187	R:R:L235	R:R:T306	2.95	Yes	No	0	8	7
188	R:R:I133	R:R:L134	2.85	No	No	0	4	5
189	R:R:I309	R:R:L235	2.85	No	Yes	0	6	8
190	R:R:I320	R:R:L245	2.85	No	No	0	8	8
191	R:R:I307	R:R:L349	2.85	No	No	0	7	9
192	R:R:L149	R:R:M181	2.83	No	No	0	6	7
193	R:R:L325	R:R:M330	2.83	No	No	0	7	5
194	R:R:L176	R:R:L234	2.77	No	No	0	9	9
195	R:R:A219	R:R:R190	2.77	No	Yes	0	6	6
196	R:R:A266	R:R:F270	2.77	No	No	0	4	5
197	R:R:A368	R:R:F371	2.77	No	No	0	1	4
198	R:R:L235	R:R:N310	2.75	Yes	No	0	8	9
199	R:R:A268	R:R:Y225	2.67	No	No	0	3	8
200	R:R:H242	R:R:I313	2.65	Yes	No	0	8	8
201	R:R:H242	R:R:I317	2.65	Yes	No	0	8	9
202	R:R:E288	R:R:N290	2.63	No	No	0	6	6
203	R:R:R300	R:R:V356	2.62	Yes	No	0	7	6
204	R:R:S148	R:R:Y145	2.54	No	Yes	0	9	7
205	R:R:S243	R:R:Y259	2.54	No	Yes	0	7	8
206	R:R:I320	R:R:R316	2.51	No	No	0	8	8
207	R:R:M140	R:R:R136	2.48	No	No	0	6	4
208	R:R:K373	R:R:R370	2.48	No	No	0	7	5
209	R:R:V271	R:R:W274	2.45	No	Yes	0	6	8
210	R:R:V360	R:R:W287	2.45	No	Yes	0	4	9
211	R:R:F386	R:R:L147	2.44	No	No	0	5	5
212	R:R:F162	R:R:L161	2.44	No	No	0	7	3
213	R:R:L128	R:R:R131	2.43	No	Yes	0	3	3
214	R:R:L134	R:R:R131	2.43	No	Yes	0	5	3
215	R:R:T178	R:R:W264	2.43	No	Yes	0	3	9
216	R:R:T301	R:R:W297	2.43	No	No	0	4	7
217	R:R:L322	R:R:R326	2.43	No	No	0	5	7
218	R:R:Q329	R:R:R326	2.34	No	No	0	7	7
219	R:R:L260	R:R:W264	2.28	No	Yes	0	6	9
220	R:R:H255	R:R:Y259	2.18	No	Yes	0	4	8
221	R:R:F345	R:R:R341	2.14	Yes	Yes	0	8	9
222	R:R:G249	R:R:G250	2.11	No	No	0	7	6
223	R:R:G228	R:R:P267	2.03	No	Yes	0	5	9
224	R:R:G265	R:R:P267	2.03	No	Yes	0	6	9
225	R:R:A358	R:R:P359	1.87	No	No	0	6	5
226	R:R:G144	R:R:S382	1.86	No	No	0	8	9
227	R:R:G385	R:R:S148	1.86	No	No	0	9	9
228	R:R:G144	R:R:V143	1.84	No	No	0	8	5
229	R:R:G238	R:R:I313	1.76	No	No	0	9	8
230	R:R:A219	R:R:S189	1.71	No	No	0	6	5
231	R:R:G238	R:R:N310	1.7	No	No	0	9	9
232	R:R:A294	R:R:V292	1.7	No	No	0	3	6
233	R:R:S323	R:R:T327	1.6	No	No	0	7	6
234	R:R:T142	R:R:V139	1.59	No	No	0	7	3
235	R:R:C226	R:R:L182	1.59	No	No	0	6	7
236	R:R:T218	R:R:V222	1.59	No	No	0	3	5
237	R:R:G406	R:R:H409	1.59	No	No	0	5	7
238	R:R:I174	R:R:S160	1.55	No	No	0	7	3
239	R:R:I276	R:R:V277	1.54	No	No	0	3	5
240	R:R:I295	R:R:V277	1.54	Yes	No	0	3	5
241	R:R:M140	R:R:V143	1.52	No	No	0	6	5
242	R:R:M305	R:R:T301	1.51	No	No	0	4	4
243	R:R:L350	R:R:V347	1.49	No	No	0	9	8
244	R:R:I272	R:R:I276	1.47	No	No	0	2	3
245	R:R:E398	R:R:S401	1.44	Yes	No	0	9	4
246	R:R:E402	R:R:S401	1.44	Yes	No	0	8	4
247	R:R:I395	R:R:L391	1.43	No	No	0	5	7
248	R:R:Q400	R:R:V399	1.43	No	No	0	8	9
249	R:R:C410	R:R:R413	1.39	No	No	0	4	4
250	R:R:L318	R:R:L321	1.38	Yes	No	0	7	9
251	R:R:L213	R:R:N210	1.37	No	No	0	4	4
252	R:R:I403	R:R:Q400	1.37	No	No	0	5	8
253	R:R:N210	R:R:Q211	1.32	No	No	0	4	3
254	R:R:R411	R:R:S415	1.32	No	No	0	4	5
255	R:R:T142	R:R:Y141	1.25	No	Yes	0	7	7
256	R:R:I403	R:R:R404	1.25	No	No	0	5	6
257	R:R:F311	R:R:L312	1.22	No	No	0	6	4
258	R:R:F311	R:R:L346	1.22	No	No	0	6	9
259	R:R:L318	R:R:R338	1.21	Yes	No	0	7	9
260	R:R:L339	R:R:R338	1.21	No	No	0	9	9
261	R:R:E282	R:R:Y281	1.12	Yes	No	0	5	3
262	R:R:H255	R:R:Y258	1.09	No	No	0	4	3
263	R:R:R404	R:R:W407	1	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:R131	4.472	5	4	3
2	R:R:Y141	6.148	5	5	7
3	R:R:Y145	7.788	5	5	7
4	R:R:R169	5.4725	4	1	9
5	R:R:F177	4.5675	4	0	9
6	R:R:F180	8.66	4	0	8
7	R:R:R183	6.4225	4	0	8
8	R:R:R190	4.6175	4	3	6
9	R:R:W233	11.274	5	7	9
10	R:R:L235	2.8825	4	0	8
11	R:R:Y240	7.23	4	0	8
12	R:R:H242	6.695	4	0	8
13	R:R:Y259	3.865	4	0	8
14	R:R:W264	7.656	5	7	9
15	R:R:P267	3.444	5	0	9
16	R:R:W274	6.01714	7	0	8
17	R:R:R278	8.288	5	0	8
18	R:R:E282	7.442	5	2	5
19	R:R:W287	5.966	5	3	9
20	R:R:I295	5.7775	4	2	3
21	R:R:R300	6.6975	4	0	7
22	R:R:L318	3.53	4	0	7
23	R:R:R341	3.3925	4	0	9
24	R:R:F345	4.63	4	1	8
25	R:R:V355	5.9325	4	0	5
26	R:R:F383	11.8125	4	0	6
27	R:R:Y392	9.18	5	1	8
28	R:R:F394	5.1725	4	6	8
29	R:R:E398	5.1475	4	1	9
30	R:R:E402	9.09	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S381	R:R:Y141	15.5052	3.82	No	Yes	5	5	7
2	R:R:E354	R:R:S381	29.6764	7.19	No	No	0	7	5
3	R:R:E354	R:R:L380	28.5877	7.95	No	No	0	7	7
4	R:R:F379	R:R:L380	25.9436	7.31	No	No	0	6	7
5	R:R:F379	R:R:F383	24.6037	17.15	No	Yes	0	6	6
6	R:R:F180	R:R:L152	22.0614	4.87	Yes	No	0	8	9
7	R:R:F180	R:R:N230	99.9402	14.5	Yes	No	0	8	9
8	R:R:N230	R:R:R183	100	8.44	No	Yes	0	9	8
9	R:R:R183	R:R:V355	99.9342	3.92	Yes	Yes	0	8	5
10	R:R:E354	R:R:V355	54.298	5.7	No	Yes	0	7	5
11	R:R:F177	R:R:L152	15.8402	3.65	Yes	No	0	9	9
12	R:R:C393	R:R:F177	12.7355	5.59	No	Yes	0	9	9
13	R:R:E398	R:R:R169	12.8432	4.65	Yes	Yes	1	9	9
14	R:R:H173	R:R:R169	35.2276	5.64	No	Yes	1	9	9
15	R:R:H173	R:R:Y392	30.2806	9.8	No	Yes	1	9	8
16	R:R:V388	R:R:Y392	90.6263	3.79	No	Yes	0	9	8
17	R:R:F180	R:R:V388	90.9134	9.18	Yes	No	0	8	9
18	R:R:I172	R:R:Y240	17.4014	6.04	No	Yes	0	9	8
19	R:R:E237	R:R:I172	39.1877	5.47	No	No	0	9	9
20	R:R:E237	R:R:Y392	34.3184	15.71	No	Yes	1	9	8
21	R:R:N396	R:R:R169	18.1911	6.03	No	Yes	1	9	9
22	R:R:I172	R:R:W233	21.6247	4.7	No	Yes	0	9	9
23	R:R:W233	R:R:W264	15.0087	18.74	Yes	Yes	7	9	9
24	R:R:R300	R:R:V355	86.421	6.54	Yes	Yes	0	7	5
25	R:R:R300	R:R:W296	84.6982	13.99	Yes	No	0	7	6
26	R:R:R289	R:R:W296	79.482	5	No	No	0	4	6
27	R:R:R278	R:R:R289	48.4357	4.26	Yes	No	0	8	4
28	R:R:R278	R:R:W274	30.6395	5	Yes	Yes	0	8	8
29	R:R:Q224	R:R:W274	38.4519	9.86	No	Yes	0	6	8
30	R:R:Q220	R:R:Q224	36.1129	7.68	No	No	0	5	6
31	R:R:Q220	R:R:R190	12.1673	5.84	No	Yes	3	5	6
32	R:R:I299	R:R:R289	30.4241	3.76	No	No	0	7	4
33	R:R:I299	R:R:W274	29.4909	11.74	No	Yes	0	7	8
34	R:R:Q220	R:R:W287	21.7563	6.57	No	Yes	3	5	9
35	R:R:C286	R:R:W287	12.3766	7.84	No	Yes	0	9	9
36	R:R:W264	R:R:Y225	10.6718	5.79	Yes	No	0	9	8
37	R:R:H242	R:R:I313	10.4624	2.65	Yes	No	0	8	8
38	R:R:G238	R:R:I313	11.91	1.76	No	No	0	9	8
39	R:R:G238	R:R:N310	13.3457	1.7	No	No	0	9	9
40	R:R:L349	R:R:N310	20.3446	6.87	No	No	0	9	9
41	R:R:L346	R:R:L349	24.4003	4.15	No	No	0	9	9
42	R:R:F314	R:R:L346	29.6166	9.74	No	No	0	9	9
43	R:R:F314	R:R:F345	51.7198	4.29	No	Yes	0	9	8
44	R:R:F345	R:R:Y392	56.2541	7.22	Yes	Yes	1	8	8
45	R:R:W296	R:R:W297	10.5462	14.99	No	No	0	6	7
46	R:R:I295	R:R:W274	12.8372	5.87	Yes	Yes	0	3	8
47	R:R:E282	R:R:R278	13.1722	11.63	Yes	Yes	0	5	8
48	R:R:F314	R:R:L318	25.6146	8.53	No	Yes	0	9	7
49	R:R:L318	R:R:L321	11.91	1.38	Yes	No	0	7	9
50	R:R:L321	R:R:L325	10.4624	6.92	No	No	0	9	7
51	R:R:N396	R:R:V399	18.4423	4.43	No	No	0	9	9
52	R:R:Q400	R:R:V399	16.9707	1.43	No	No	0	8	9
53	R:R:R404	R:R:W407	10.9649	1	No	No	0	6	5
54	R:R:I403	R:R:R404	12.4843	1.25	No	No	0	5	6
55	R:R:I403	R:R:Q400	13.9917	1.37	No	No	0	5	8
56	R:R:I276	R:R:V277	10.8692	1.54	No	No	0	3	5
57	R:R:I295	R:R:V277	14.4703	1.54	Yes	No	0	3	5
58	R:R:S381	R:R:Y145	12.8612	10.17	No	Yes	5	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8WA3_nogp

PDB Summary
PDB	8WA3_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.63
Number of Linked Nodes	251
Number of Links	263
Number of Hubs	30
Number of Links mediated by Hubs	120
Number of Communities	8
Number of Nodes involved in Communities	33
Number of Links involved in Communities	37

Path Summary
Number Of Nodes in MetaPath	59
Number Of Links MetaPath	58
Number of Shortest Paths	31562
Length Of Smallest Path	3
Average Path Length	13.9226
Length of Longest Path	30
Minimum Path Strength	1.125
Average Path Strength	6.71517
Maximum Path Strength	16.615
Minimum Path Correlation	0.7
Average Path Correlation	0.94027
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	52.4427
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.356
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• peptide hormone receptor binding • protein binding • binding • corticotropin-releasing hormone receptor binding • signaling receptor binding • G protein-coupled receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • mu-type opioid receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • adrenergic receptor binding • D1 dopamine receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • ionotropic glutamate receptor binding • glutamate receptor binding • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • molecular function regulator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • insulin-like growth factor receptor binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • intracellular anatomical structure • cytoplasm • protein binding • binding • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body • amide binding • glucagon family peptide binding • peptide hormone binding • hormone binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • gastric inhibitory peptide receptor activity • peptide receptor activity • G protein-coupled peptide receptor activity • response to wounding • response to axon injury • response to metal ion • response to calcium ion • negative adaptation of signaling pathway • negative regulation of signaling • negative regulation of biological process • desensitization of G protein-coupled receptor signaling pathway • regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • regulation of response to stimulus • adaptation of signaling pathway • regulation of cell communication • metabolic process • generation of precursor metabolites and energy • response to hexose • response to monosaccharide • response to carbohydrate • response to glucose • gastric inhibitory peptide signaling pathway • pancreas development • endocrine system development • endocrine pancreas development • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • cell surface receptor signaling pathway • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to fatty acid • response to nutrient levels • response to nutrient • positive regulation of cell communication • positive regulation of establishment of protein localization • positive regulation of insulin secretion • positive regulation of peptide hormone secretion • positive regulation of protein localization • positive regulation of biological process • positive regulation of secretion by cell • positive regulation of protein transport • positive regulation of hormone secretion • positive regulation of secretion • positive regulation of cellular process • positive regulation of peptide secretion • positive regulation of protein secretion • positive regulation of transport • positive regulation of signaling
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P48546
Sequence	>8WA3_nogp_Chain_R L D Q R L I L E R L Q V M Y T V G Y S L S L A T L L L A L L I L S L F R R L H C T R N Y I H I N L F T S F M L R A A A I L S R D R L L P N Q A L A A C R T A Q I V T Q Y C V G A N Y T W L L V E G V Y L H S L L V L V G G S E E G H F R Y Y L L L G W G A P A L F V I P W V I V R Y L Y E N T Q C W E R N E V K A I W W I I R T P I L M T I L I N F L I F I R I L G I L L S K L R T R Q M R C R D Y R L R L A R S T L F L V P L L G V H E V V F A P V T E E Q A R G A L R F A K L G F E I F L S S F Q G F L V S V L Y C F I N K E V Q S E I R R G W H H C R L R R S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7RBT	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	LSN3556672	chim(NtGi1-Gs)/β1/γ2	3.08	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RBT (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	LSN3556672		3.08	2022-04-13	doi.org/10.1073/pnas.2116506119
	8WA3	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	2.86	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		2.86	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	7FIN	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-	Gs/β1/γ2	3.1	2022-02-23	doi.org/10.1038/s41467-022-28683-0
	7FIN (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-		3.1	2022-02-23	doi.org/10.1038/s41467-022-28683-0
	7FIY	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VAB	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VAB (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-		3.2	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7RA3	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	chim(NtGi1-Gs)/β1/γ2	3.24	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		3.24	2022-04-13	doi.org/10.1073/pnas.2116506119
	8ITL	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.23	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITL (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.23	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITM	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.13	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITM (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.13	2023-10-18	doi.org/10.1073/pnas.2306145120
	7DTY	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	Gs/β1/γ2	2.98	2021-08-04	doi.org/10.7554/eLife.68719
	7DTY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		2.98	2021-08-04	doi.org/10.7554/eLife.68719
	8YW4	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ2	3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW4 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-		3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0

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