psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Y1	R:R:Q224	11.27	No	No	0	0	6
2	L:L:Y1	R:R:V227	13.88	No	No	0	0	6
3	L:L:Y1	R:R:W296	7.72	No	Yes	0	0	6
4	L:L:?2	L:L:T5	11.29	Yes	No	0	0	0
5	L:L:?2	R:R:E377	10.15	Yes	No	0	0	7
6	L:L:?2	R:R:I378	6.83	Yes	No	0	0	8
7	L:L:Q3	R:R:Y141	10.15	No	Yes	1	0	7
8	L:L:Q3	R:R:Y145	11.27	No	Yes	1	0	7
9	L:L:Q3	R:R:I187	15.1	No	No	1	0	7
10	L:L:T5	R:R:L374	4.42	No	No	0	0	6
11	L:L:F6	R:R:L134	3.65	No	No	0	0	5
12	L:L:F6	R:R:L137	3.65	No	No	0	0	6
13	L:L:T7	R:R:R190	7.76	No	Yes	0	0	6
14	L:L:T7	R:R:E288	5.64	No	No	0	0	6
15	L:L:S8	R:R:N290	11.92	No	No	0	0	6
16	L:L:?13	L:L:D9	4.76	Yes	No	0	0	0
17	L:L:L14	L:L:Y10	14.07	No	Yes	5	0	0
18	L:L:Y10	R:R:L134	8.21	Yes	No	0	0	5
19	L:L:Y10	R:R:Q138	7.89	Yes	No	0	0	5
20	L:L:Y10	R:R:R196	5.14	Yes	Yes	5	0	3
21	L:L:S11	R:R:E288	8.62	No	No	0	0	6
22	L:L:S11	R:R:R289	5.27	No	No	0	0	4
23	L:L:?13	L:L:I12	6.26	Yes	No	0	0	0
24	L:L:?13	L:L:L14	6.07	Yes	No	0	0	0
25	L:L:?13	L:L:K17	3.71	Yes	No	0	0	0
26	L:L:L14	R:R:R196	17.01	No	Yes	5	0	3
27	L:L:D15	L:L:Q19	5.22	No	No	0	0	0
28	L:L:D15	R:R:A32	4.63	No	No	0	0	4
29	L:L:D15	R:R:R289	9.53	No	No	0	0	4
30	L:L:K16	R:R:F127	3.72	No	No	0	0	2
31	L:L:K17	R:R:F127	7.44	No	No	0	0	2
32	L:L:K17	R:R:R131	12.38	No	No	0	0	3
33	L:L:?20	L:L:Q19	3.82	Yes	No	0	0	0
34	L:L:Q19	R:R:L35	6.65	No	No	0	0	5
35	R:R:A32	R:R:Y36	4	No	No	0	4	3
36	R:R:E34	R:R:Q37	8.92	No	No	0	5	4
37	R:R:R38	R:R:Y42	4.12	No	No	0	5	7
38	R:R:E40	R:R:W39	5.45	No	No	0	3	6
39	R:R:Q47	R:R:R44	7.01	No	No	0	3	5
40	R:R:L128	R:R:R131	6.07	No	No	0	3	3
41	R:R:D129	R:R:Q130	5.22	No	No	0	1	3
42	R:R:F371	R:R:Q130	4.68	No	No	0	4	3
43	R:R:E135	R:R:R131	4.65	No	No	0	3	3
44	R:R:R136	R:R:V139	3.92	No	No	0	4	3
45	R:R:D191	R:R:Q138	6.53	No	No	0	7	5
46	R:R:Y141	R:R:Y145	3.97	Yes	Yes	1	7	7
47	R:R:D191	R:R:Y141	6.9	No	Yes	0	7	7
48	R:R:L188	R:R:T142	4.42	No	No	0	7	7
49	R:R:F383	R:R:G144	9.03	No	No	0	6	8
50	R:R:I187	R:R:Y145	13.3	No	Yes	1	7	7
51	R:R:S381	R:R:Y145	3.82	No	Yes	0	5	7
52	R:R:F386	R:R:L147	4.87	Yes	No	0	5	5
53	R:R:G385	R:R:S148	3.71	No	No	0	9	9
54	R:R:L149	R:R:M181	5.65	No	No	0	6	7
55	R:R:F386	R:R:T151	7.78	Yes	No	0	5	7
56	R:R:F177	R:R:L152	8.53	No	Yes	0	9	9
57	R:R:F180	R:R:L152	3.65	Yes	Yes	0	8	9
58	R:R:L152	R:R:S389	7.51	Yes	No	0	9	8
59	R:R:L153	R:R:M181	4.24	No	No	0	3	7
60	R:R:I174	R:R:L156	4.28	No	No	0	7	6
61	R:R:L159	R:R:N170	5.49	No	Yes	0	8	9
62	R:R:I174	R:R:S160	4.64	No	No	0	7	3
63	R:R:F162	R:R:L161	4.87	No	No	0	7	3
64	R:R:E402	R:R:F162	10.49	No	No	0	8	7
65	R:R:E402	R:R:R164	10.47	No	No	0	8	7
66	R:R:R164	R:R:R405	10.66	No	Yes	0	7	8
67	R:R:L165	R:R:N170	4.12	Yes	Yes	0	9	9
68	R:R:E398	R:R:L165	5.3	No	Yes	0	9	9
69	R:R:H166	R:R:Y171	13.07	No	No	0	7	6
70	R:R:C167	R:R:R169	6.96	No	No	7	8	9
71	R:R:C167	R:R:N170	4.72	No	Yes	7	8	9
72	R:R:N170	R:R:R169	4.82	Yes	No	7	9	9
73	R:R:E398	R:R:R169	4.65	No	No	0	9	9
74	R:R:H173	R:R:N170	3.83	No	Yes	0	9	9
75	R:R:F256	R:R:Y171	9.28	No	No	0	5	6
76	R:R:I172	R:R:W233	4.7	No	Yes	0	9	9
77	R:R:E237	R:R:I172	5.47	Yes	No	0	9	9
78	R:R:I172	R:R:Y240	6.04	No	Yes	0	9	8
79	R:R:E237	R:R:H173	9.85	Yes	No	0	9	9
80	R:R:H173	R:R:Y392	4.36	No	Yes	0	9	8
81	R:R:N175	R:R:W233	13.56	No	Yes	0	9	9
82	R:R:L176	R:R:L234	5.54	No	No	0	9	9
83	R:R:E237	R:R:L176	5.3	Yes	No	0	9	9
84	R:R:S179	R:R:W264	4.94	No	Yes	0	9	9
85	R:R:F180	R:R:N230	13.29	Yes	No	0	8	9
86	R:R:F180	R:R:Q384	4.68	Yes	No	6	8	9
87	R:R:F180	R:R:G385	7.53	Yes	No	0	8	9
88	R:R:F180	R:R:V388	6.55	Yes	No	6	8	9
89	R:R:C226	R:R:L182	6.35	No	No	0	6	7
90	R:R:R183	R:R:V227	3.92	No	No	0	8	6
91	R:R:N230	R:R:R183	10.85	No	No	0	9	8
92	R:R:R183	R:R:S381	3.95	No	No	0	8	5
93	R:R:I187	R:R:T223	4.56	No	No	0	7	6
94	R:R:Q220	R:R:R190	9.35	No	Yes	0	5	6
95	R:R:R190	R:R:T223	5.17	Yes	No	0	6	6
96	R:R:D191	R:R:L194	4.07	No	No	0	7	7
97	R:R:A212	R:R:P195	3.74	No	No	0	6	3
98	R:R:C216	R:R:P195	7.53	No	No	0	9	3
99	R:R:P197	R:R:R196	5.76	No	Yes	0	4	3
100	R:R:P199	R:R:R196	4.32	No	Yes	0	3	3
101	R:R:G198	R:R:P199	4.06	No	No	0	3	3
102	R:R:A212	R:R:W209	3.89	No	No	0	6	4
103	R:R:C216	R:R:C286	7.28	No	No	0	9	9
104	R:R:N283	R:R:R217	12.05	No	No	3	6	8
105	R:R:R217	R:R:W287	23.99	No	Yes	3	8	9
106	R:R:Q220	R:R:Q224	11.52	No	No	0	5	6
107	R:R:P267	R:R:Y225	9.74	Yes	Yes	0	9	8
108	R:R:L234	R:R:N230	4.12	No	No	0	9	9
109	R:R:I303	R:R:Y231	12.09	No	No	0	7	8
110	R:R:E354	R:R:Y231	10.1	No	No	0	7	8
111	R:R:P267	R:R:T232	5.25	Yes	No	0	9	6
112	R:R:V236	R:R:W233	6.13	No	Yes	0	8	9
113	R:R:G263	R:R:W233	9.85	No	Yes	0	9	9
114	R:R:W233	R:R:W264	17.81	Yes	Yes	0	9	9
115	R:R:L262	R:R:V236	4.47	No	No	0	6	8
116	R:R:E237	R:R:L349	14.58	Yes	No	0	9	9
117	R:R:V239	R:R:Y259	3.79	No	Yes	0	7	8
118	R:R:L244	R:R:Y240	15.24	No	Yes	0	8	8
119	R:R:Y240	R:R:Y259	5.96	Yes	Yes	0	8	8
120	R:R:I317	R:R:L241	4.28	No	No	0	9	9
121	R:R:H242	R:R:V246	12.45	No	No	0	8	7
122	R:R:L247	R:R:S243	4.5	No	No	0	5	7
123	R:R:R316	R:R:V246	14.38	No	No	0	8	7
124	R:R:H255	R:R:Y259	7.62	No	Yes	0	4	8
125	R:R:F270	R:R:P302	17.34	No	No	0	5	9
126	R:R:R278	R:R:W274	8	Yes	Yes	0	8	8
127	R:R:I299	R:R:W274	8.22	No	Yes	0	7	8
128	R:R:R278	R:R:T284	9.06	Yes	No	0	8	4
129	R:R:R278	R:R:W287	13.99	Yes	Yes	0	8	9
130	R:R:N290	R:R:R278	4.82	No	Yes	0	6	8
131	R:R:I295	R:R:R278	8.77	No	Yes	0	3	8
132	R:R:L280	R:R:Y279	4.69	No	No	0	3	3
133	R:R:N283	R:R:Y279	4.65	No	No	3	6	3
134	R:R:W287	R:R:Y279	3.86	Yes	No	3	9	3
135	R:R:E282	R:R:Y281	4.49	No	No	0	5	3
136	R:R:E282	R:R:V292	5.7	No	No	0	5	6
137	R:R:E282	R:R:I295	5.47	No	No	0	5	3
138	R:R:N283	R:R:W287	9.04	No	Yes	3	6	9
139	R:R:Q285	R:R:T284	7.09	No	No	0	3	4
140	R:R:Q285	R:R:R289	15.19	No	No	0	3	4
141	R:R:C286	R:R:E288	4.56	No	No	0	9	6
142	R:R:N290	R:R:W296	5.65	No	Yes	0	6	6
143	R:R:W296	R:R:W297	3.75	Yes	No	4	6	7
144	R:R:R300	R:R:W296	16.99	Yes	Yes	4	7	6
145	R:R:R300	R:R:W297	4	Yes	No	4	7	7
146	R:R:T301	R:R:W297	4.85	No	No	0	4	7
147	R:R:P302	R:R:T301	5.25	No	No	0	9	4
148	R:R:L350	R:R:N310	6.87	Yes	No	0	9	9
149	R:R:F311	R:R:I315	3.77	No	No	0	6	5
150	R:R:F311	R:R:V352	5.24	No	No	0	6	6
151	R:R:F311	R:R:V355	3.93	No	No	0	6	5
152	R:R:F314	R:R:L318	4.87	Yes	No	2	9	7
153	R:R:F314	R:R:T343	3.89	Yes	No	2	9	9
154	R:R:F314	R:R:L346	6.09	Yes	No	2	9	9
155	R:R:F314	R:R:L350	3.65	Yes	Yes	2	9	9
156	R:R:F314	R:R:V352	7.87	Yes	No	0	9	6
157	R:R:L318	R:R:T343	4.42	No	No	2	7	9
158	R:R:L321	R:R:S342	7.51	No	No	0	9	9
159	R:R:L325	R:R:Y335	7.03	No	Yes	0	7	5
160	R:R:L325	R:R:R338	6.07	No	No	0	7	9
161	R:R:R326	R:R:Y335	10.29	No	Yes	0	7	5
162	R:R:R328	R:R:T327	6.47	No	No	0	6	6
163	R:R:L339	R:R:Y335	4.69	No	Yes	0	9	5
164	R:R:R338	R:R:R341	9.6	No	No	0	9	9
165	R:R:F345	R:R:R341	7.48	No	No	0	8	9
166	R:R:F345	R:R:Y392	7.22	No	Yes	0	8	8
167	R:R:L346	R:R:L350	4.15	No	Yes	2	9	9
168	R:R:V347	R:R:V352	4.81	No	No	0	8	6
169	R:R:H353	R:R:V347	4.15	Yes	No	0	8	8
170	R:R:P348	R:R:Y392	5.56	No	Yes	0	9	8
171	R:R:L349	R:R:L350	4.15	No	Yes	0	9	9
172	R:R:L349	R:R:Y392	19.93	No	Yes	0	9	8
173	R:R:E354	R:R:H353	7.39	No	Yes	0	7	8
174	R:R:H353	R:R:L380	9	Yes	No	0	8	7
175	R:R:H353	R:R:Q384	9.89	Yes	No	0	8	9
176	R:R:E354	R:R:E377	8.88	No	No	0	7	7
177	R:R:F357	R:R:V356	3.93	No	No	0	7	6
178	R:R:E377	R:R:F357	9.33	No	No	0	7	7
179	R:R:F357	R:R:L380	6.09	No	No	0	7	7
180	R:R:E362	R:R:V360	5.7	No	No	0	5	4
181	R:R:F371	R:R:R370	7.48	No	No	0	4	5
182	R:R:K373	R:R:L374	5.64	No	No	0	7	6
183	R:R:F376	R:R:F379	7.5	No	No	0	4	6
184	R:R:F379	R:R:F383	6.43	No	No	0	6	6
185	R:R:F383	R:R:F386	4.29	No	Yes	0	6	5
186	R:R:Q384	R:R:V388	4.3	No	No	6	9	9
187	R:R:L387	R:R:L391	4.15	No	No	0	6	7
188	R:R:V388	R:R:Y392	5.05	No	Yes	0	9	8
189	R:R:F394	R:R:V390	5.24	No	No	0	8	5
190	R:R:L391	R:R:Y392	5.86	No	Yes	0	7	8
191	R:R:C393	R:R:F394	5.59	No	No	0	9	8
192	R:R:N396	R:R:V399	4.43	No	No	0	9	9
193	R:R:H408	R:R:W407	4.23	No	No	0	4	5
194	R:R:R411	R:R:W407	15.99	No	No	0	4	5
195	R:R:A155	R:R:C393	3.61	No	No	0	9	9
196	R:R:A186	R:R:C226	3.61	No	No	0	6	6
197	R:R:L188	R:R:Y145	3.52	No	Yes	0	7	7
198	R:R:L201	R:R:Y200	3.52	No	No	0	2	4
199	R:R:L262	R:R:Y258	3.52	No	No	0	6	3
200	R:R:Q364	R:R:R370	3.5	No	No	0	5	5
201	R:R:G375	R:R:L137	3.42	No	No	0	5	6
202	R:R:A155	R:R:S389	3.42	No	No	0	9	8
203	R:R:L182	R:R:W264	3.42	No	Yes	0	7	9
204	R:R:I272	R:R:P273	3.39	No	No	0	2	4
205	R:R:H409	R:R:R405	3.39	No	Yes	0	7	8
206	R:R:Q329	R:R:Y335	3.38	No	Yes	0	7	5
207	L:L:?2	L:L:G4	3.28	Yes	No	0	0	0
208	R:R:C393	R:R:I158	3.27	No	No	0	9	8
209	R:R:I221	R:R:V275	3.07	No	No	0	5	6
210	R:R:I307	R:R:V355	3.07	No	No	0	7	5
211	L:L:?20	L:L:A21	3.02	Yes	No	0	0	0
212	R:R:L165	R:R:V399	2.98	Yes	No	0	9	9
213	R:R:L235	R:R:V239	2.98	No	No	0	8	7
214	R:R:I313	R:R:I317	2.94	No	No	0	8	9
215	R:R:I320	R:R:K324	2.91	No	No	0	8	9
216	R:R:G33	R:R:Y36	2.9	No	No	0	5	3
217	R:R:W264	R:R:Y225	2.89	Yes	Yes	0	9	8
218	R:R:I174	R:R:L159	2.85	No	No	0	7	8
219	R:R:I309	R:R:L235	2.85	No	No	0	6	8
220	R:R:I320	R:R:L245	2.85	No	No	0	8	8
221	R:R:I317	R:R:L346	2.85	No	No	0	9	9
222	R:R:L152	R:R:M181	2.83	Yes	No	0	9	7
223	L:L:L26	L:L:L27	2.77	No	No	0	0	0
224	R:R:A219	R:R:R190	2.77	No	Yes	0	6	6
225	R:R:L241	R:R:L245	2.77	No	No	0	9	8
226	R:R:L321	R:R:L325	2.77	No	No	0	9	7
227	R:R:L260	R:R:N175	2.75	No	No	0	6	9
228	R:R:E402	R:R:I403	2.73	No	No	0	8	5
229	R:R:A184	R:R:Y145	2.67	No	Yes	0	8	7
230	R:R:H242	R:R:I313	2.65	No	No	0	8	8
231	R:R:F386	R:R:S148	2.64	Yes	No	0	5	9
232	R:R:A229	R:R:W264	2.59	No	Yes	0	8	9
233	L:L:?20	L:L:E24	2.54	Yes	No	0	0	0
234	R:R:S382	R:R:Y141	2.54	No	Yes	1	9	7
235	R:R:S382	R:R:Y145	2.54	No	Yes	1	9	7
236	R:R:S243	R:R:Y259	2.54	No	Yes	0	7	8
237	R:R:V271	R:R:Y225	2.52	No	Yes	0	6	8
238	R:R:F371	R:R:I133	2.51	No	No	0	4	4
239	R:R:F345	R:R:I395	2.51	No	No	0	8	5
240	R:R:T168	R:R:Y240	2.5	No	Yes	0	8	8
241	R:R:E252	R:R:H255	2.46	No	No	0	7	4
242	L:L:F22	R:R:L201	2.44	No	No	0	0	2
243	R:R:F394	R:R:L154	2.44	No	No	0	8	5
244	R:R:F270	R:R:L269	2.44	No	No	0	5	4
245	R:R:T178	R:R:W264	2.43	No	Yes	0	3	9
246	R:R:L322	R:R:R326	2.43	No	No	0	5	7
247	R:R:M140	R:R:Y141	2.39	No	Yes	0	6	7
248	R:R:I221	R:R:W274	2.35	No	Yes	0	5	8
249	R:R:I298	R:R:W274	2.35	No	Yes	0	8	8
250	R:R:H166	R:R:R163	2.26	No	No	0	7	8
251	R:R:G249	R:R:G250	2.11	No	No	0	7	6
252	L:L:F22	R:R:Y36	2.06	No	No	0	0	3
253	R:R:G228	R:R:P267	2.03	No	Yes	0	5	9
254	R:R:G265	R:R:P267	2.03	No	Yes	0	6	9
255	L:L:A18	R:R:P197	1.87	No	No	0	0	4
256	R:R:A266	R:R:P267	1.87	No	Yes	0	4	9
257	R:R:A358	R:R:P359	1.87	No	No	0	6	5
258	R:R:G144	R:R:V143	1.84	No	No	0	8	5
259	R:R:G249	R:R:V248	1.84	No	No	0	7	7
260	R:R:G238	R:R:I313	1.76	No	No	0	9	8
261	R:R:A219	R:R:S189	1.71	No	No	0	6	5
262	R:R:C226	R:R:V222	1.71	No	No	0	6	5
263	R:R:G351	R:R:L234	1.71	No	No	0	9	9
264	R:R:G250	R:R:L247	1.71	No	No	0	6	5
265	R:R:G319	R:R:L322	1.71	No	No	0	8	5
266	R:R:A294	R:R:V292	1.7	No	No	0	3	6
267	R:R:I298	R:R:P273	1.69	No	No	0	8	4
268	R:R:A215	R:R:T218	1.68	No	No	0	3	3
269	R:R:V139	R:R:V143	1.6	No	No	0	3	5
270	R:R:A215	R:R:L193	1.58	No	No	0	3	5
271	R:R:A219	R:R:L193	1.58	No	No	0	6	5
272	R:R:A365	R:R:L369	1.58	No	No	0	6	4
273	R:R:T232	R:R:T306	1.57	No	No	0	6	7
274	R:R:I276	R:R:V275	1.54	No	No	0	3	6
275	R:R:I295	R:R:V277	1.54	No	No	0	3	5
276	R:R:I298	R:R:V277	1.54	No	No	0	8	5
277	R:R:L322	R:R:S323	1.5	No	No	0	5	7
278	R:R:G406	R:R:R405	1.5	No	Yes	0	5	8
279	R:R:L308	R:R:V355	1.49	No	No	0	3	5
280	R:R:I133	R:R:L134	1.43	No	No	0	4	5
281	R:R:E34	R:R:T31	1.41	No	No	0	5	5
282	R:R:E291	R:R:T31	1.41	No	No	0	4	5
283	R:R:L308	R:R:M305	1.41	No	No	0	3	4
284	R:R:L153	R:R:L157	1.38	No	No	0	3	1
285	L:L:?20	L:L:I23	1.37	Yes	No	0	0	0
286	R:R:K397	R:R:Q400	1.36	No	No	0	5	8
287	R:R:E135	R:R:L132	1.33	No	No	0	3	3
288	R:R:A268	R:R:Y225	1.33	No	Yes	0	3	8
289	R:R:R192	R:R:S189	1.32	No	No	0	4	5
290	R:R:N210	R:R:Q211	1.32	No	No	0	4	3
291	R:R:R300	R:R:T361	1.29	Yes	No	0	7	7
292	R:R:I403	R:R:R404	1.25	No	No	0	5	6
293	R:R:L165	R:R:R164	1.21	Yes	No	0	9	7
294	R:R:L304	R:R:R300	1.21	No	Yes	0	4	7
295	R:R:D334	R:R:R336	1.19	No	No	0	6	6
296	L:L:I23	R:R:W39	1.17	No	No	0	0	6
297	R:R:Q47	R:R:R43	1.17	No	No	0	3	4
298	L:L:L26	R:R:W39	1.14	No	No	0	0	6
299	R:R:H408	R:R:R405	1.13	No	Yes	0	4	8
300	R:R:R38	R:R:R41	1.07	No	No	0	5	5
301	R:R:F256	R:R:Y259	1.03	No	Yes	0	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?2	7.8875	4	0	0
2	L:L:Y10	8.8275	4	5	0
3	L:L:?13	5.2	4	0	0
4	L:L:?20	2.6875	4	0	0
5	R:R:Y141	5.19	5	1	7
6	R:R:Y145	5.87	7	1	7
7	R:R:L152	5.63	4	0	9
8	R:R:L165	3.4025	4	0	9
9	R:R:N170	4.596	5	7	9
10	R:R:F180	7.14	5	6	8
11	R:R:R190	6.2625	4	0	6
12	R:R:R196	8.0575	4	5	3
13	R:R:Y225	4.12	4	0	8
14	R:R:W233	10.41	5	0	9
15	R:R:E237	8.8	4	0	9
16	R:R:Y240	7.435	4	0	8
17	R:R:Y259	4.188	5	0	8
18	R:R:W264	5.68	6	0	9
19	R:R:P267	4.184	5	0	9
20	R:R:W274	5.23	4	0	8
21	R:R:R278	8.928	5	0	8
22	R:R:W287	12.72	4	3	9
23	R:R:W296	8.5275	4	4	6
24	R:R:R300	5.8725	4	4	7
25	R:R:F314	5.274	5	2	9
26	R:R:Y335	6.3475	4	0	5
27	R:R:L350	4.705	4	2	9
28	R:R:H353	7.6075	4	0	8
29	R:R:F386	4.895	4	0	5
30	R:R:Y392	7.99667	6	0	8
31	R:R:R405	4.17	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E354	R:R:H353	12.2882	7.39	No	Yes	0	7	8
2	R:R:H353	R:R:Q384	22.711	9.89	Yes	No	0	8	9
3	R:R:F180	R:R:Q384	15.7664	4.68	Yes	No	6	8	9
4	R:R:F180	R:R:N230	61.2234	13.29	Yes	No	0	8	9
5	R:R:N230	R:R:R183	100	10.85	No	No	0	9	8
6	R:R:R183	R:R:V227	60.792	3.92	No	No	0	8	6
7	L:L:Y1	R:R:V227	60.1119	13.88	No	No	0	0	6
8	R:R:S381	R:R:Y145	49.1373	3.82	No	Yes	0	5	7
9	R:R:R183	R:R:S381	49.7863	3.95	No	No	0	8	5
10	R:R:Y141	R:R:Y145	35.0653	3.97	Yes	Yes	1	7	7
11	L:L:Y1	R:R:Q224	15.3117	11.27	No	No	0	0	6
12	R:R:Q220	R:R:Q224	14.6471	11.52	No	No	0	5	6
13	R:R:Q220	R:R:R190	14.1303	9.35	No	Yes	0	5	6
14	R:R:R190	R:R:T223	22.3107	5.17	Yes	No	0	6	6
15	R:R:I187	R:R:T223	23.1152	4.56	No	No	0	7	6
16	R:R:I187	R:R:Y145	19.1629	13.3	No	Yes	1	7	7
17	L:L:Y10	R:R:L134	13.3647	8.21	Yes	No	0	0	5
18	L:L:Y10	R:R:Q138	34.3075	7.89	Yes	No	0	0	5
19	R:R:D191	R:R:Q138	35.4695	6.53	No	No	0	7	5
20	R:R:D191	R:R:Y141	37.7701	6.9	No	Yes	0	7	7
21	L:L:T7	R:R:R190	21.5374	7.76	No	Yes	0	0	6
22	L:L:T7	R:R:E288	19.7653	5.64	No	No	0	0	6
23	R:R:N290	R:R:W296	39.5655	5.65	No	Yes	0	6	6
24	L:L:Y1	R:R:W296	47.2952	7.72	No	Yes	0	0	6
25	L:L:?13	L:L:L14	13.3647	6.07	Yes	No	0	0	0
26	L:L:L14	L:L:Y10	14.445	14.07	No	Yes	5	0	0
27	R:R:N290	R:R:R278	37.8556	4.82	No	Yes	0	6	8
28	R:R:R278	R:R:T284	19.2018	9.06	Yes	No	0	8	4
29	R:R:Q285	R:R:T284	18.2652	7.09	No	No	0	3	4
30	R:R:Q285	R:R:R289	17.7444	15.19	No	No	0	3	4
31	L:L:D15	R:R:R289	21.6928	9.53	No	No	0	0	4
32	L:L:D15	L:L:Q19	13.0344	5.22	No	No	0	0	0
33	L:L:?20	L:L:Q19	10.5277	3.82	Yes	No	0	0	0
34	R:R:F180	R:R:G385	16.9711	7.53	Yes	No	0	8	9
35	R:R:G385	R:R:S148	15.5993	3.71	No	No	0	9	9
36	R:R:F386	R:R:S148	14.2196	2.64	Yes	No	0	5	9
37	R:R:F383	R:R:F386	10.0342	4.29	No	Yes	0	6	5
38	R:R:F180	R:R:L152	18.3351	3.65	Yes	Yes	0	8	9
39	R:R:L152	R:R:S389	10.0342	7.51	Yes	No	0	9	8
40	R:R:F180	R:R:V388	45.4531	6.55	Yes	No	6	8	9
41	R:R:V388	R:R:Y392	53.3227	5.05	No	Yes	0	9	8
42	R:R:H173	R:R:Y392	31.0858	4.36	No	Yes	0	9	8
43	R:R:H173	R:R:N170	38.3919	3.83	No	Yes	0	9	9
44	R:R:L234	R:R:N230	49.3471	4.12	No	No	0	9	9
45	R:R:L176	R:R:L234	48.8341	5.54	No	No	0	9	9
46	R:R:E237	R:R:L176	48.6748	5.3	Yes	No	0	9	9
47	R:R:E237	R:R:H173	29.7567	9.85	Yes	No	0	9	9
48	R:R:L165	R:R:N170	26.0415	4.12	Yes	Yes	0	9	9
49	R:R:L165	R:R:R164	19.7536	1.21	Yes	No	0	9	7
50	R:R:E237	R:R:I172	54.8072	5.47	Yes	No	0	9	9
51	R:R:I172	R:R:Y240	24.6813	6.04	No	Yes	0	9	8
52	R:R:Y240	R:R:Y259	20.7329	5.96	Yes	Yes	0	8	8
53	R:R:I172	R:R:W233	32.3605	4.7	No	Yes	0	9	9
54	R:R:W233	R:R:W264	23.3833	17.81	Yes	Yes	0	9	9
55	R:R:C286	R:R:E288	10.5005	4.56	No	No	0	9	6
56	R:R:W264	R:R:Y225	12.6574	2.89	Yes	Yes	0	9	8
57	R:R:L349	R:R:Y392	24.7552	19.93	No	Yes	0	9	8
58	R:R:E237	R:R:L349	25.7695	14.58	Yes	No	0	9	9
59	R:R:L349	R:R:L350	28.0818	4.15	No	Yes	0	9	9
60	R:R:L346	R:R:L350	17.1226	4.15	No	Yes	2	9	9
61	R:R:I317	R:R:L346	16.6097	2.85	No	No	0	9	9
62	R:R:F345	R:R:Y392	17.3208	7.22	No	Yes	0	8	8
63	R:R:F345	R:R:R341	14.9658	7.48	No	No	0	8	9
64	R:R:R338	R:R:R341	13.7572	9.6	No	No	0	9	9
65	R:R:L325	R:R:R338	12.533	6.07	No	No	0	7	9
66	R:R:A219	R:R:R190	12.704	2.77	No	Yes	0	6	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Y1	R:R:Q224	11.27	0	No	No	0	6	0	1
L:L:Y1	R:R:V227	13.88	0	No	No	0	6	0	1
L:L:Y1	R:R:W296	7.72	0	No	Yes	0	6	0	1
L:L:?2	R:R:E377	10.15	0	Yes	No	0	7	0	1
L:L:?2	R:R:I378	6.83	0	Yes	No	0	8	0	1
L:L:Q3	R:R:Y141	10.15	1	No	Yes	0	7	0	1
L:L:Q3	R:R:Y145	11.27	1	No	Yes	0	7	0	1
L:L:Q3	R:R:I187	15.1	1	No	No	0	7	0	1
L:L:T5	R:R:L374	4.42	0	No	No	0	6	0	1
L:L:F6	R:R:L134	3.65	0	No	No	0	5	0	1
L:L:F6	R:R:L137	3.65	0	No	No	0	6	0	1
L:L:T7	R:R:R190	7.76	0	No	Yes	0	6	0	1
L:L:T7	R:R:E288	5.64	0	No	No	0	6	0	1
L:L:S8	R:R:N290	11.92	0	No	No	0	6	0	1
L:L:Y10	R:R:L134	8.21	5	Yes	No	0	5	0	1
L:L:Y10	R:R:Q138	7.89	5	Yes	No	0	5	0	1
L:L:Y10	R:R:R196	5.14	5	Yes	Yes	0	3	0	1
L:L:S11	R:R:E288	8.62	0	No	No	0	6	0	1
L:L:S11	R:R:R289	5.27	0	No	No	0	4	0	1
L:L:L14	R:R:R196	17.01	5	No	Yes	0	3	0	1
L:L:D15	R:R:A32	4.63	0	No	No	0	4	0	1
L:L:D15	R:R:R289	9.53	0	No	No	0	4	0	1
L:L:K16	R:R:F127	3.72	0	No	No	0	2	0	1
L:L:K17	R:R:F127	7.44	0	No	No	0	2	0	1
L:L:K17	R:R:R131	12.38	0	No	No	0	3	0	1
L:L:Q19	R:R:L35	6.65	0	No	No	0	5	0	1
R:R:A32	R:R:Y36	4	0	No	No	4	3	1	1
R:R:E40	R:R:W39	5.45	0	No	No	3	6	2	1
R:R:L128	R:R:R131	6.07	0	No	No	3	3	2	1
R:R:E135	R:R:R131	4.65	0	No	No	3	3	2	1
R:R:D191	R:R:Q138	6.53	0	No	No	7	5	2	1
R:R:Y141	R:R:Y145	3.97	1	Yes	Yes	7	7	1	1
R:R:D191	R:R:Y141	6.9	0	No	Yes	7	7	2	1
R:R:I187	R:R:Y145	13.3	1	No	Yes	7	7	1	1
R:R:S381	R:R:Y145	3.82	0	No	Yes	5	7	2	1
R:R:R183	R:R:V227	3.92	0	No	No	8	6	2	1
R:R:R183	R:R:S381	3.95	0	No	No	8	5	2	2
R:R:I187	R:R:T223	4.56	1	No	No	7	6	1	2
R:R:Q220	R:R:R190	9.35	0	No	Yes	5	6	2	1
R:R:R190	R:R:T223	5.17	0	Yes	No	6	6	1	2
R:R:P197	R:R:R196	5.76	0	No	Yes	4	3	1	1
R:R:P199	R:R:R196	4.32	0	No	Yes	3	3	2	1
R:R:Q220	R:R:Q224	11.52	0	No	No	5	6	2	1
R:R:N290	R:R:R278	4.82	0	No	Yes	6	8	1	2
R:R:Q285	R:R:R289	15.19	0	No	No	3	4	2	1
R:R:C286	R:R:E288	4.56	0	No	No	9	6	2	1
R:R:N290	R:R:W296	5.65	0	No	Yes	6	6	1	1
R:R:W296	R:R:W297	3.75	4	Yes	No	6	7	1	2
R:R:R300	R:R:W296	16.99	4	Yes	Yes	7	6	2	1
R:R:R300	R:R:W297	4	4	Yes	No	7	7	2	2
R:R:E354	R:R:E377	8.88	0	No	No	7	7	2	1
R:R:E377	R:R:F357	9.33	0	No	No	7	7	1	2
R:R:K373	R:R:L374	5.64	0	No	No	7	6	2	1
R:R:L188	R:R:Y145	3.52	0	No	Yes	7	7	2	1
R:R:L201	R:R:Y200	3.52	0	No	No	2	4	1	2
R:R:G375	R:R:L137	3.42	0	No	No	5	6	2	1
R:R:G33	R:R:Y36	2.9	0	No	No	5	3	2	1
R:R:A219	R:R:R190	2.77	0	No	Yes	6	6	2	1
R:R:A184	R:R:Y145	2.67	0	No	Yes	8	7	2	1
R:R:S382	R:R:Y141	2.54	1	No	Yes	9	7	2	1
R:R:S382	R:R:Y145	2.54	1	No	Yes	9	7	2	1
L:L:F22	R:R:L201	2.44	0	No	No	0	2	0	1
R:R:M140	R:R:Y141	2.39	0	No	Yes	6	7	2	1
L:L:F22	R:R:Y36	2.06	0	No	No	0	3	0	1
L:L:A18	R:R:P197	1.87	0	No	No	0	4	0	1
R:R:I133	R:R:L134	1.43	0	No	No	4	5	2	1
L:L:I23	R:R:W39	1.17	0	No	No	0	6	0	1
L:L:L26	R:R:W39	1.14	0	No	No	0	6	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8YW4_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.65
Number of Linked Nodes	293
Number of Links	301
Number of Hubs	31
Number of Links mediated by Hubs	127
Number of Communities	7
Number of Nodes involved in Communities	26
Number of Links involved in Communities	30

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	49943
Length Of Smallest Path	3
Average Path Length	13.9368
Length of Longest Path	28
Minimum Path Strength	1.22667
Average Path Strength	6.67719
Maximum Path Strength	18.99
Minimum Path Correlation	0.7
Average Path Correlation	0.954663
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	61.7886
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	32.0678
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • amide binding • glucagon family peptide binding • peptide hormone binding • hormone binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • gastric inhibitory peptide receptor activity • peptide receptor activity • G protein-coupled peptide receptor activity • response to stress • response to wounding • response to axon injury • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • response to metal ion • response to calcium ion • negative adaptation of signaling pathway • negative regulation of signaling • negative regulation of biological process • desensitization of G protein-coupled receptor signaling pathway • regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • regulation of response to stimulus • adaptation of signaling pathway • regulation of cell communication • metabolic process • generation of precursor metabolites and energy • response to hexose • response to monosaccharide • response to carbohydrate • response to glucose • gastric inhibitory peptide signaling pathway • pancreas development • endocrine system development • endocrine pancreas development • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • cell surface receptor signaling pathway • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to fatty acid • response to nutrient levels • response to nutrient • positive regulation of cell communication • positive regulation of establishment of protein localization • positive regulation of insulin secretion • positive regulation of peptide hormone secretion • positive regulation of protein localization • positive regulation of biological process • positive regulation of secretion by cell • positive regulation of protein transport • positive regulation of hormone secretion • positive regulation of secretion • positive regulation of cellular process • positive regulation of peptide secretion • positive regulation of protein secretion • positive regulation of transport • positive regulation of signaling
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	AIB
PDB Residues	L:L:?2 L:L:?20
Environment Details	Open EMBL-EBI Page
Code	AIB
Name	2-aminoisobutyric acid
Synonyms	α-aminoisobutyric acid
Identifier
Formula	C4 H9 N O2
Molecular Weight	103.12
SMILES
PubChem	5245672
Formal Charge	0
Total Atoms	16
Total Chiral Atoms	0
Total Bonds	15
Total Aromatic Bonds	0


Code	2ML
PDB Residues	L:L:?13
Environment Details	Open EMBL-EBI Page
Code	2ML
Name	alpha-Methylleucine
Synonyms	alpha-Methylleucine (S)-2-Methylleucine 2-Methyl-L-leucine
Identifier
Formula	C7 H15 N O2
Molecular Weight	145.199
SMILES
PubChem	6951130
Formal Charge	0
Total Atoms	25
Total Chiral Atoms	1
Total Bonds	24
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P48546
Sequence	>8YW4_nogp_Chain_R T A G E L Y Q R W E R Y R R E C Q E F L D Q R L I L E R L Q V M Y T V G Y S L S L A T L L L A L L I L S L F R R L H C T R N Y I H I N L F T S F M L R A A A I L S R D R L L P R P G P Y L L W N Q A L A A C R T A Q I V T Q Y C V G A N Y T W L L V E G V Y L H S L L V L V G G S E E G H F R Y Y L L L G W G A P A L F V I P W V I V R Y L Y E N T Q C W E R N E V K A I W W I I R T P I L M T I L I N F L I F I R I L G I L L S K L R T R Q D Y R L R L A R S T L F L V P L L G V H E V V F A P V T E E Q A R G A L R F A K L G F E I F L S S F Q G F L V S V L Y C F I N K E V Q S E I R R G W H H C R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7RBT	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	LSN3556672	chim(NtGi1-Gs)/β1/γ2	3.08	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RBT (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	LSN3556672		3.08	2022-04-13	doi.org/10.1073/pnas.2116506119
	8WA3	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	2.86	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		2.86	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	7FIN	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-	Gs/β1/γ2	3.1	2022-02-23	doi.org/10.1038/s41467-022-28683-0
	7FIN (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-		3.1	2022-02-23	doi.org/10.1038/s41467-022-28683-0
	7FIY	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VAB	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VAB (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-		3.2	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7RA3	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	chim(NtGi1-Gs)/β1/γ2	3.24	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		3.24	2022-04-13	doi.org/10.1073/pnas.2116506119
	8ITL	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.23	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITL (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.23	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITM	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.13	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITM (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.13	2023-10-18	doi.org/10.1073/pnas.2306145120
	7DTY	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	Gs/β1/γ2	2.98	2021-08-04	doi.org/10.7554/eLife.68719
	7DTY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		2.98	2021-08-04	doi.org/10.7554/eLife.68719
	8YW4	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ2	3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW4 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-		3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0

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