Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:F127 4.2254172
2R:R:Q130 4.7025173
3R:R:Y141 9.41754207
4R:R:Y145 8.5965207
5R:R:L152 4.784509
6R:R:R169 10.866569
7R:R:F177 5.065409
8R:R:F180 8.28508
9R:R:M181 4.9925407
10R:R:R183 5.706508
11R:R:R190 5.8775406
12R:R:W233 10.0645139
13R:R:L235 4.94408
14R:R:Y240 6.476568
15R:R:G249 2.32407
16R:R:W264 6.836676139
17R:R:P267 5.08409
18R:R:W274 5.568508
19R:R:I295 3.6525403
20R:R:R300 6.835407
21R:R:K324 7.074149
22R:R:L349 4.7925409
23R:R:E354 4.175407
24R:R:F357 9.61254217
25R:R:T361 3.57254227
26R:R:I378 5.395408
27R:R:F386 9.16254185
28R:R:S389 4.8754188
29R:R:Y392 11.49408
30R:R:E398 7.7469
31R:R:R405 3.4675408
32A:A:Y37 7.8025414
33A:A:Q59 8.1075499
34A:A:F219 7.26508
35A:A:H220 8.82517
36A:A:M221 3.805408
37A:A:F222 8.83667617
38A:A:K233 6.34519
39A:A:W234 6.115619
40A:A:C237 4.205418
41A:A:F238 8.204519
42A:A:V247 2.74497
43A:A:F273 6.2754159
44A:A:W277 8.2556156
45A:A:W281 9.62515
46A:A:I288 6.375409
47A:A:L289 4.0475409
48A:A:F290 5.9954119
49A:A:F312 7.4654198
50A:A:E314 6.0254196
51A:A:Y318 4.4525406
52A:A:P321 4.485405
53A:A:D331 7.4054254
54A:A:V334 4.27404
55A:A:K338 5.71754105
56A:A:Y339 5.67403
57A:A:F340 9.6685197
58A:A:R342 6.9654104
59A:A:F345 7.765408
60A:A:Y360 8.905408
61A:A:F363 7.8454105
62A:A:E370 9.24754114
63A:A:F376 3.87254248
64A:A:R385 10.0765145
65A:A:Y391 6.652564
66B:B:L30 4.3625475
67B:B:V40 4.936573
68B:B:H54 9.884529
69B:B:K57 8.412519
70B:B:Y59 12.1418
71B:B:M61 4.825426
72B:B:W63 6.85333627
73B:B:Q75 8.885419
74B:B:D76 7.214519
75B:B:I80 7.16428
76B:B:W82 7.91571729
77B:B:D83 7.914238
78B:B:K89 5.56857729
79B:B:I93 7.5175407
80B:B:L95 5.055488
81B:B:W99 8.55571719
82B:B:Y105 4.445606
83B:B:C114 4.1125488
84B:B:C121 4.135458
85B:B:Y124 6.1275486
86B:B:E138 4.1825486
87B:B:L139 6.2175409
88B:B:H142 8.715459
89B:B:Y145 7.30571718
90B:B:L146 4.455457
91B:B:C149 4.25458
92B:B:R150 5.2525406
93B:B:F151 4.44667609
94B:B:L152 3.56403
95B:B:I157 4.7525457
96B:B:T159 5.82333659
97B:B:W169 8.96833658
98B:B:D170 6.13754289
99B:B:F180 6.242537
100B:B:T181 2.75754292
101B:B:H183 7.124539
102B:B:D186 5.9775419
103B:B:V187 5.4325439
104B:B:F199 7.3875439
105B:B:V200 5.5575446
106B:B:C204 3.876517
107B:B:D205 6.0925439
108B:B:K209 7.774536
109B:B:W211 9.024538
110B:B:F222 8.31448
111B:B:H225 9.9975449
112B:B:D228 7.062519
113B:B:I232 3.534548
114B:B:F234 5.395405
115B:B:F235 7.1975416
116B:B:P236 6.39417
117B:B:F241 8.0875446
118B:B:T243 5.5175448
119B:B:D247 8.6975409
120B:B:R251 9.3175408
121B:B:F253 9.3675446
122B:B:D258 6.84447
123B:B:L261 4.8425405
124B:B:Y264 5.598515
125B:B:H266 3.835414
126B:B:C271 4.22415
127B:B:F278 6.406517
128B:B:R283 7.352579
129B:B:L285 4.974516
130B:B:Y289 6.395617
131B:B:D290 7.965416
132B:B:C294 4.55405
133B:B:N295 7.635416
134B:B:W297 4.07429718
135B:B:L300 5.5875476
136B:B:R304 6.05415
137B:B:H311 8.615129
138B:B:R314 15.8825418
139B:B:W332 12.1033619
140B:B:D333 7.454129
141B:B:K337 7.08754126
142B:B:W339 7.65254129
143G:G:R27 3.782508
144G:G:Y40 8.205416
145G:G:D48 6.8875409
146G:G:L51 5.3425476
147G:G:P60 7.1854169
148G:G:F61 4.943336168
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:L134 R:R:L137 10.61676.92NoNo056
2R:R:I378 R:R:L137 11.23724.28YesNo086
3R:R:I378 R:R:Y141 16.80199.67YesYes087
4R:R:Y141 R:R:Y145 17.704719.86YesYes2077
5R:R:S381 R:R:Y145 46.66865.09NoYes057
6R:R:E354 R:R:S381 47.258510.06YesNo075
7R:R:E354 R:R:R183 50.20813.49YesYes078
8R:R:N230 R:R:R183 27.10112.05NoYes098
9R:R:F180 R:R:N230 38.067418.12YesNo089
10R:R:Q384 R:R:R183 26.67763.5NoYes098
11R:R:F180 R:R:Q384 27.23785.86YesNo089
12R:R:F180 R:R:L176 66.10084.87YesNo089
13R:R:L176 R:R:Y392 66.34284.69NoYes098
14R:R:H173 R:R:Y392 75.008527.22NoYes098
15R:R:C393 R:R:H173 87.13982.95NoNo099
16R:R:C393 R:R:L159 87.35294.76NoNo098
17R:R:I158 R:R:L159 87.98942.85NoNo088
18R:R:F162 R:R:I158 88.200711.3NoNo078
19R:R:E402 R:R:F162 88.62210.49NoNo087
20R:R:E402 R:R:R164 88.831915.12NoNo087
21B:B:K337 R:R:R164 88.75124.95YesNo067
22R:R:H173 R:R:R169 12.918915.8NoYes099
23R:R:N230 R:R:S179 11.61365.96NoNo099
24R:R:I187 R:R:R190 23.36663.76NoYes076
25R:R:Q220 R:R:R190 21.54910.51NoYes056
26R:R:Q220 R:R:Q224 15.46843.84NoNo056
27R:R:Q224 R:R:W274 14.85836.57NoYes068
28B:B:K337 B:B:W339 88.87315.8YesYes1269
29B:B:L308 B:B:W339 89.896210.25NoYes079
30B:B:C294 B:B:L308 79.25147.94YesNo057
31B:B:C294 B:B:L318 84.50323.17YesNo056
32B:B:L318 B:B:S275 87.60044.5NoNo068
33B:B:S275 B:B:T274 87.73943.2NoNo088
34B:B:R314 B:B:T274 82.45269.06YesNo188
35B:B:R314 B:B:W332 10025.99YesYes189
36B:B:K57 B:B:W332 31.517410.44YesYes199
37A:A:D240 B:B:K57 15.91058.3NoYes069
38A:A:D240 B:B:W99 15.89254.47NoYes069
39A:A:F238 B:B:W99 52.997114.03YesYes199
40A:A:F238 A:A:L44 65.846815.83YesNo099
41A:A:I244 A:A:L44 64.78234.28NoNo089
42A:A:I244 A:A:T285 64.24943.04NoNo087
43A:A:D284 A:A:T285 63.71614.34NoNo047
44A:A:D284 A:A:R356 63.18237.15NoNo042
45A:A:R356 A:A:R389 62.64814.26NoNo024
46A:A:R389 A:A:Y358 62.11344.12NoNo044
47A:A:R385 A:A:Y358 31.908711.32YesNo1454
48A:A:R385 R:R:K324 29.71666.19YesYes1459
49A:A:L394 R:R:K324 12.74614.23NoYes089
50A:A:L388 A:A:L394 11.02064.15NoNo088
51B:B:K57 B:B:Q75 16.10656.78YesYes199
52B:B:Q75 B:B:W99 31.48967.67YesYes199
53B:B:W332 B:B:Y59 68.818815.43YesYes198
54B:B:Q75 B:B:Y59 15.726618.04YesYes198
55A:A:C237 B:B:Y59 53.32315.38YesYes188
56A:A:C237 B:B:W99 15.6535.22YesYes189
57A:A:Q384 A:A:R380 16.75667.01NoNo067
58A:A:Q384 R:R:K324 17.32775.42NoYes069
59A:A:R42 A:A:Y37 15.409915.43NoYes194
60A:A:F222 A:A:R42 15.60766.41YesNo179
61A:A:Y358 R:R:R328 29.669415.43NoNo1446
62A:A:Y360 R:R:R328 29.15614.12YesNo086
63B:B:C271 B:B:D290 21.07293.11YesYes156
64B:B:D83 B:B:R68 17.186317.87YesNo085
65B:B:R68 B:B:Y85 16.972714.4NoNo054
66B:B:Y85 G:G:P60 14.975111.13NoYes1649
67B:B:M325 G:G:P60 16.17478.39NoYes059
68B:B:M325 G:G:P49 17.9648.39NoNo057
69G:G:D48 G:G:P49 19.24443.22YesNo097
70G:G:D48 G:G:L51 15.44378.14YesYes096
71B:B:V40 G:G:L51 13.45494.47YesYes736
72B:B:I43 B:B:V40 17.48613.07NoYes033
73B:B:I43 B:B:M45 18.64934.37NoNo034
74B:B:L308 B:B:M45 18.8914.24NoNo074
75A:A:N23 B:B:K89 10.06635.6NoYes079
76A:A:Y37 B:B:D76 11.86623.45YesYes149
77A:A:N292 A:A:T364 11.51087.31NoNo099
78A:A:F290 A:A:T364 18.39999.08YesNo099
79A:A:D378 A:A:I288 12.060212.59NoYes079
80A:A:D378 A:A:Y360 28.127710.34NoYes078
81A:A:D378 A:A:H362 15.505713.87NoNo079
82A:A:Q227 B:B:N119 21.16896.6NoNo099
83A:A:Q227 A:A:W234 15.19955.48NoYes199
84A:A:W234 B:B:L117 27.08593.42YesNo099
85A:A:C237 B:B:L117 38.01183.17YesNo089
86A:A:W234 B:B:Y145 18.2046.75YesYes198
87B:B:M101 B:B:Y145 11.08917.18NoYes098
88B:B:L117 B:B:M101 11.17994.24NoNo099
89A:A:K233 B:B:Y145 31.78773.58YesYes198
90A:A:R231 A:A:W234 26.32466NoYes099
91A:A:L272 A:A:R231 25.88427.29NoNo089
92A:A:K233 B:B:D228 29.68329.68YesYes199
93A:A:F246 A:A:L272 25.44346.09NoNo098
94A:A:F246 A:A:L289 24.99953.65NoYes099
95A:A:F345 A:A:L289 10.34986.09YesYes089
96A:A:P361 A:A:R342 12.11827.21NoYes1054
97A:A:L289 A:A:P361 12.62023.28YesNo095
98B:B:C148 B:B:L190 10.99013.17NoNo065
99B:B:H62 B:B:R150 17.7839.03NoYes066
100B:B:H62 B:B:Y105 17.67493.27NoYes066
101B:B:L69 B:B:Y105 18.4484.69NoYes056
102B:B:D83 B:B:L69 18.62394.07YesNo085
103B:B:D258 B:B:F222 13.14284.78YesYes478
104B:B:F222 B:B:F253 15.23538.57YesYes486
105B:B:H225 B:B:T243 15.93948.21YesYes498
106B:B:H225 B:B:S245 16.997612.55YesNo099
107B:B:D247 B:B:S245 17.34828.83YesNo099
108B:B:D247 B:B:S227 28.51655.89YesNo096
109B:B:D228 B:B:S227 28.82414.42YesNo196
110B:B:D247 B:B:T249 10.48135.78YesNo096
111B:B:W297 B:B:Y289 15.4674.82YesYes187
112B:B:C271 B:B:Y289 19.49664.03YesYes157
113B:B:L79 B:B:V71 10.83714.47NoNo078
114B:B:V71 B:B:Y105 12.60825.05NoYes086
115B:B:H142 B:B:S161 19.850516.74YesNo099
116B:B:D163 B:B:S161 19.93797.36NoNo099
117B:B:D163 B:B:T143 20.574410.12NoNo095
118B:B:G144 B:B:T143 20.68633.64NoNo085
119B:B:G144 B:B:N119 20.80265.09NoNo089
120B:B:H142 B:B:T159 12.04066.85YesYes599
121R:R:I187 R:R:Y145 23.64328.46NoYes2077
122A:A:F222 A:A:F238 10.14723.22YesYes179
123A:A:F238 A:A:W234 15.07744.01YesYes199
124B:B:D290 B:B:R314 16.402715.48YesYes168
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8ITM
Class B1
SubFamily Peptide
Type Glucagon
SubType GIP
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.13
Date 2023-10-18
D.O.I. 10.1073/pnas.2306145120
Net Summary
Imin 3.04
Number of Linked Nodes 859
Number of Links 998
Number of Hubs 148
Number of Links mediated by Hubs 536
Number of Communities 31
Number of Nodes involved in Communities 202
Number of Links involved in Communities 268
Path Summary
Number Of Nodes in MetaPath 125
Number Of Links MetaPath 124
Number of Shortest Paths 845361
Length Of Smallest Path 3
Average Path Length 29.9253
Length of Longest Path 60
Minimum Path Strength 1.235
Average Path Strength 7.46862
Maximum Path Strength 21.51
Minimum Path Correlation 0.7
Average Path Correlation 0.976339
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.7027
Average % Of Corr. Nodes 47.5301
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.314
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP48546
Sequence
>8ITM_Chain_R
NEAFLDQRL ILERLQVMY TVGYSLSLA TLLLALLIL SLFRRLHCT 
RNYIHINLF TSFMLRAAA ILSRDRLLP NQALAACRT AQIVTQYCV 
GANYTWLLV EGVYLHSLL VLVGGSEEG HFRYYLLLG WGAPALFVI 
PWVIVRYLY ENTQCWERN EVKAIWWII RTPILMTIL INFLIFIRI 
LGILLSKLR TRQMRCRDY RLRLARSTL FLVPLLGVH EVVFAPVTE 
EQARGALRF AKLGFEIFL SSFQGFLVS VLYCFINKE VQSEIRRGW 
HHCRLRRS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8ITM_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGAGESGK 
NTIVKQMSG IFETKFQVD KVNFHMFDV GAQRDERRK WIQCFNDVT 
AIIFVVASS QTNRLQAAL KLFDSIWNN KWLRDTSVI LFLNKQDLL 
AEKVLAGKS KIEDYFPEF ARYTTPEDA TPEPGEDPR VTRAKYFIR 
DEFLRISTA SGDGRHYCY PHFTCAVDT ENIRRVFND CRDIIQRMH 
LRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>8ITM_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>8ITM_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7DTYB1PeptideGlucagonGIPHomo sapiensGIP-Gs/&β;1/&γ;22.982021-08-0410.7554/eLife.68719
7FINB1PeptideGlucagonGIPHomo sapiensPeptide-20; GGL-Gs/&β;1/&γ;23.12022-02-2310.1038/s41467-022-28683-0
7FIYB1PeptideGlucagonGIPHomo sapiensTirzepatide-Gs/&β;1/&γ;23.42022-03-0210.1038/s41467-022-28683-0
7RA3B1PeptideGlucagonGIPHomo sapiensGIP-chim(NtGi1-Gs)/&β;1/&γ;23.242022-04-1310.1073/pnas.2116506119
7RBTB1PeptideGlucagonGIPHomo sapiensTirzepatidePubChem 163183774chim(NtGi1-Gs)/&β;1/&γ;23.082022-04-1310.1073/pnas.2116506119
7VABB1PeptideGlucagonGIPHomo sapiensNon-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;23.22022-03-0210.1038/s41467-022-28683-0
8ITLB1PeptideGlucagonGIPHomo sapiens--Gs/&β;1/&γ;23.232023-10-1810.1073/pnas.2306145120
8ITMB1PeptideGlucagonGIPHomo sapiens--Gs/&β;1/&γ;23.132023-10-1810.1073/pnas.2306145120
8WA3B1PeptideGlucagonGIPHomo sapiens--Gs/&β;1/&γ;22.862024-03-0610.1038/s41421-024-00649-0




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8ITM.zip



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