Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 7.8025414
2A:A:H41 5.014196
3A:A:Q59 7.0285109
4A:A:D215 5.0854205
5A:A:F219 7.265198
6A:A:H220 8.82517
7A:A:M221 3.805408
8A:A:F222 8.83667617
9A:A:K233 6.34519
10A:A:W234 6.115619
11A:A:C237 4.205418
12A:A:F238 8.204519
13A:A:V247 2.744107
14A:A:F273 6.2754129
15A:A:W277 8.2556126
16A:A:W281 9.62515
17A:A:I288 6.375409
18A:A:L289 4.0475409
19A:A:F290 5.9954219
20A:A:Q294 6.3325466
21A:A:F312 7.4654168
22A:A:E314 6.0254166
23A:A:Y318 4.4525406
24A:A:V334 5.412564
25A:A:K338 5.654565
26A:A:Y339 5.67403
27A:A:F340 9.6685167
28A:A:R342 6.965464
29A:A:F345 7.765408
30A:A:S349 4.475407
31A:A:Y358 5.6354134
32A:A:Y360 8.62408
33A:A:F363 7.845465
34A:A:F376 3.87254208
35A:A:R385 7.5185135
36A:A:Y391 6.652574
37B:B:L30 4.3625485
38B:B:T34 4.8275485
39B:B:V40 4.61683
40B:B:H54 9.884539
41B:B:K57 8.412519
42B:B:Y59 12.1418
43B:B:M61 4.825436
44B:B:W63 6.85333637
45B:B:L70 5.795435
46B:B:Q75 8.885419
47B:B:D76 7.214519
48B:B:L79 4.8375407
49B:B:I80 7.16438
50B:B:W82 7.91571739
51B:B:D83 7.914188
52B:B:K89 5.56857739
53B:B:I93 7.5175407
54B:B:L95 5.055498
55B:B:W99 8.55571719
56B:B:Y105 4.445606
57B:B:C114 4.1125498
58B:B:C121 4.135458
59B:B:Y124 6.1275496
60B:B:E138 4.1825496
61B:B:L139 6.2175409
62B:B:H142 7.558559
63B:B:Y145 7.79857718
64B:B:L146 4.455457
65B:B:C149 4.25458
66B:B:R150 5.2525406
67B:B:F151 4.44667609
68B:B:L152 3.56403
69B:B:I157 4.7525457
70B:B:T159 5.82333659
71B:B:W169 8.96833658
72B:B:D170 6.1375429
73B:B:F180 6.242527
74B:B:H183 7.124529
75B:B:D186 7.156519
76B:B:V187 5.4325429
77B:B:F199 7.3875429
78B:B:V200 5.5575446
79B:B:C204 4.188517
80B:B:D205 6.0925429
81B:B:K209 6.96526
82B:B:W211 9.024528
83B:B:F222 8.31448
84B:B:H225 9.9975449
85B:B:D228 7.062519
86B:B:I232 3.534548
87B:B:F234 5.395405
88B:B:F235 6.36516
89B:B:P236 6.39417
90B:B:F241 8.0875446
91B:B:T243 5.5175448
92B:B:D247 8.6975409
93B:B:R251 9.3175408
94B:B:F253 8.096546
95B:B:R256 7.94754259
96B:B:D258 6.84447
97B:B:L261 5.86405
98B:B:Y264 5.598515
99B:B:H266 3.835414
100B:B:C271 4.22415
101B:B:F278 6.406517
102B:B:R283 7.352589
103B:B:L285 4.974516
104B:B:Y289 6.395617
105B:B:D290 7.965416
106B:B:C294 4.55405
107B:B:N295 7.635416
108B:B:W297 4.07429718
109B:B:L300 5.5875486
110B:B:R304 6.05415
111B:B:H311 8.615119
112B:B:R314 15.8825418
113B:B:L318 4.5325406
114B:B:D323 5.0675437
115B:B:M325 7.7275405
116B:B:W332 12.1033619
117B:B:D333 6.7854119
118B:B:F335 7.89404
119B:B:L336 4.19437
120B:B:K337 6.64116
121B:B:W339 7.65254119
122G:G:R27 4.43408
123G:G:Y40 8.205416
124G:G:D48 6.8875409
125G:G:L51 5.3425486
126G:G:P60 7.1854149
127G:G:F61 4.943336148
128R:R:Q130 4.71254273
129R:R:R131 4.50754273
130R:R:Y141 9.41754297
131R:R:Y145 8.5965297
132R:R:L152 4.784509
133R:R:R169 10.866579
134R:R:F177 5.065409
135R:R:F180 7.401676308
136R:R:M181 4.9925407
137R:R:R183 6.172508
138R:R:R190 5.8775406
139R:R:W233 10.0645159
140R:R:L235 4.94408
141R:R:Y240 6.476578
142R:R:W264 6.836676159
143R:R:P267 5.08409
144R:R:W274 5.568508
145R:R:I295 3.6525403
146R:R:R300 5.992507
147R:R:K324 7.074139
148R:R:R341 3.4675409
149R:R:L349 4.7925409
150R:R:I378 5.395408
151R:R:S382 2.5525409
152R:R:F386 8.83254175
153R:R:Y392 11.49408
154R:R:N396 8.025479
155R:R:E398 7.7479
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D83 B:B:R68 54.382417.87YesNo085
2B:B:R68 B:B:Y85 55.089514.4NoNo054
3B:B:Y85 G:G:P60 55.286811.13NoYes1449
4B:B:M325 G:G:P60 63.76898.39YesYes059
5B:B:M325 G:G:P49 65.6448.39YesNo057
6G:G:D48 G:G:P49 68.55553.22YesNo097
7B:B:S279 G:G:D48 42.00228.83NoYes099
8B:B:L284 B:B:S279 16.97253NoNo059
9B:B:L284 B:B:V296 17.55065.96NoNo055
10B:B:L286 B:B:V296 17.87822.98NoNo075
11B:B:C294 B:B:L286 35.0793.17YesNo057
12B:B:C294 B:B:G288 17.23273.92YesNo057
13B:B:G288 B:B:V315 17.17773.68NoNo077
14B:B:H311 B:B:V315 17.17984.15YesNo097
15B:B:D333 B:B:H311 90.67125.04YesYes1199
16B:B:D333 B:B:F335 90.412110.75YesYes094
17B:B:F335 R:R:R164 10011.76YesNo047
18R:R:E402 R:R:R164 99.82474.65NoNo087
19R:R:E402 R:R:F162 99.648610.49NoNo087
20R:R:F162 R:R:I158 99.295711.3NoNo078
21R:R:I158 R:R:L159 99.1192.85NoNo088
22R:R:C393 R:R:L159 98.58754.76NoNo098
23R:R:C393 R:R:H173 98.412.95NoNo099
24R:R:H173 R:R:R169 33.039615.8NoYes099
25A:A:Y391 R:R:R169 30.463111.32YesYes749
26A:A:Y391 R:R:Y240 30.02245.96YesYes748
27R:R:L244 R:R:Y240 25.80184.69NoYes088
28A:A:H387 R:R:L244 25.559216.71NoNo088
29A:A:H387 A:A:M386 25.31679.19NoNo083
30A:A:M386 A:A:R356 25.07463.72NoNo032
31A:A:R356 A:A:R389 24.83339.6NoNo024
32A:A:R389 A:A:Y358 24.59264.12NoYes044
33B:B:S279 G:G:L50 25.39066.01NoNo099
34B:B:V327 G:G:L50 25.57294.47NoNo069
35B:B:L286 B:B:V327 17.12665.96NoNo076
36B:B:C294 B:B:L318 18.7993.17YesYes056
37B:B:L318 B:B:T329 54.68062.95YesNo068
38B:B:H311 B:B:T329 64.18098.21YesNo098
39G:G:D48 G:G:L51 27.17678.14YesYes096
40B:B:V40 G:G:L51 25.85564.47YesYes836
41B:B:I43 B:B:V40 29.60733.07NoYes033
42B:B:I43 B:B:M45 29.96224.37NoNo034
43B:B:L308 B:B:M45 30.11624.24NoNo074
44B:B:L308 B:B:W339 29.666610.25NoYes079
45B:B:T329 B:B:W339 10.271210.92NoYes089
46B:B:K337 B:B:W339 20.05395.8YesYes1169
47B:B:H311 B:B:K337 10.230913.1YesYes1196
48B:B:K337 B:B:T50 10.32723YesNo063
49B:B:R52 B:B:T50 10.23599.06NoNo073
50B:B:F335 B:B:R52 10.16796.41YesNo047
51A:A:Y358 A:A:Y360 14.75652.98YesYes048
52A:A:D378 A:A:Y360 14.249510.34NoYes078
53A:A:R231 A:A:W234 12.48286NoYes099
54A:A:L272 A:A:R231 12.27087.29NoNo089
55A:A:F246 A:A:L272 12.05886.09NoNo098
56A:A:F246 A:A:L289 11.84523.65NoYes099
57B:B:D83 B:B:L69 53.87534.07YesNo085
58B:B:L69 B:B:Y105 53.47834.69NoYes056
59B:B:H62 B:B:Y105 39.0323.27NoYes066
60B:B:H62 B:B:R150 38.70379.03NoYes066
61B:B:C148 B:B:R150 28.28865.57NoYes066
62B:B:H142 B:B:S161 10.454716.74YesNo099
63B:B:D163 B:B:S161 10.4927.36NoNo099
64B:B:D163 B:B:T143 10.74510.12NoNo095
65B:B:G144 B:B:T143 10.80243.64NoNo085
66B:B:G144 B:B:N119 10.86395.09NoNo089
67A:A:Q227 B:B:N119 11.06096.6NoNo099
68A:A:K233 B:B:Y145 14.16983.58YesYes198
69A:A:K233 B:B:D228 12.67329.68YesYes199
70B:B:W332 B:B:Y59 27.624815.43YesYes198
71A:A:C237 B:B:Y59 25.72545.38YesYes188
72A:A:C237 B:B:L117 23.94843.17YesNo089
73B:B:R314 B:B:W332 32.292825.99YesYes189
74R:R:H173 R:R:Y392 65.782927.22NoYes098
75R:R:F177 R:R:Y392 11.22386.19YesYes098
76R:R:L152 R:R:S389 10.82543YesNo098
77R:R:F386 R:R:S389 10.08833.96YesNo1758
78B:B:C148 B:B:L190 28.20563.17NoNo065
79B:B:F199 B:B:L190 23.43076.09YesNo095
80B:B:F199 B:B:W211 13.963912.03YesYes298
81B:B:K209 B:B:W211 12.729410.44YesYes268
82B:B:K209 B:B:T221 11.43216.01YesNo067
83B:B:T221 G:G:E22 10.9958.47NoNo079
84G:G:E22 G:G:L19 10.55761.33NoNo099
85B:B:D228 B:B:S227 12.17754.42YesNo196
86B:B:D247 B:B:S227 12.00655.89YesNo096
87B:B:V71 B:B:Y105 16.71865.05NoYes086
88B:B:L79 B:B:V71 14.33754.47YesNo078
89B:B:I93 B:B:L79 10.52257.14YesYes077
90B:B:R314 B:B:T274 27.31529.06YesNo188
91B:B:S275 B:B:T274 31.02153.2NoNo088
92R:R:L176 R:R:Y392 53.15134.69NoYes098
93R:R:F180 R:R:L176 52.94624.87YesNo089
94R:R:F180 R:R:N230 29.005618.12YesNo089
95R:R:N230 R:R:R183 25.035712.05NoYes098
96R:R:E354 R:R:R183 46.90965.82NoYes078
97R:R:E354 R:R:S381 45.931610.06NoNo075
98R:R:S381 R:R:Y145 45.44165.09NoYes057
99R:R:Y141 R:R:Y145 13.510119.86YesYes2977
100R:R:I378 R:R:Y141 12.65199.67YesYes087
101R:R:I378 R:R:L137 10.13164.28YesNo086
102R:R:F180 R:R:Q384 25.03925.86YesNo3089
103R:R:Q384 R:R:R183 24.81153.5NoYes098
104R:R:I187 R:R:Y145 27.02038.46NoYes2977
105R:R:I187 R:R:R190 26.6713.76NoYes076
106R:R:Q220 R:R:R190 25.176610.51NoYes056
107R:R:Q220 R:R:Q224 20.18193.84NoNo056
108R:R:Q224 R:R:W274 19.68146.57NoYes068
109B:B:L318 B:B:S275 31.04014.5YesNo068
110A:A:W234 B:B:L117 18.12553.42YesNo099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8ITM
Class B1
SubFamily Peptide
Type Glucagon
SubType GIP
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.13
Date 2023-10-18
D.O.I. 10.1073/pnas.2306145120
Net Summary
Imin 2.89
Number of Linked Nodes 851
Number of Links 1016
Number of Hubs 155
Number of Links mediated by Hubs 556
Number of Communities 31
Number of Nodes involved in Communities 213
Number of Links involved in Communities 287
Path Summary
Number Of Nodes in MetaPath 111
Number Of Links MetaPath 110
Number of Shortest Paths 1361169
Length Of Smallest Path 3
Average Path Length 34.821
Length of Longest Path 67
Minimum Path Strength 1.235
Average Path Strength 7.23641
Maximum Path Strength 21.51
Minimum Path Correlation 0.71
Average Path Correlation 0.981964
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.77778
Average % Of Corr. Nodes 42.8554
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.056
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8ITM_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGAGESGK 
NTIVKQMSG IFETKFQVD KVNFHMFDV GAQRDERRK WIQCFNDVT 
AIIFVVASS QTNRLQAAL KLFDSIWNN KWLRDTSVI LFLNKQDLL 
AEKVLAGKS KIEDYFPEF ARYTTPEDA TPEPGEDPR VTRAKYFIR 
DEFLRISTA SGDGRHYCY PHFTCAVDT ENIRRVFND CRDIIQRMH 
LRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>8ITM_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>8ITM_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP48546
Sequence
>8ITM_Chain_R
NEAFLDQRL ILERLQVMY TVGYSLSLA TLLLALLIL SLFRRLHCT 
RNYIHINLF TSFMLRAAA ILSRDRLLP NQALAACRT AQIVTQYCV 
GANYTWLLV EGVYLHSLL VLVGGSEEG HFRYYLLLG WGAPALFVI 
PWVIVRYLY ENTQCWERN EVKAIWWII RTPILMTIL INFLIFIRI 
LGILLSKLR TRQMRCRDY RLRLARSTL FLVPLLGVH EVVFAPVTE 
EQARGALRF AKLGFEIFL SSFQGFLVS VLYCFINKE VQSEIRRGW 
HHCRLRRS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8YW4B1PeptideGlucagonGIPHomo sapiensRetatrutide-chim(NtGi1-Gs)/β1/γ223.262024-09-18doi.org/10.1038/s41421-024-00700-0
8YW4 (No Gprot) B1PeptideGlucagonGIPHomo sapiensRetatrutide-3.262024-09-18doi.org/10.1038/s41421-024-00700-0
8WA3B1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ22.862024-03-0610.1038/s41421-024-00649-0
8WA3 (No Gprot) B1PeptideGlucagonGIPHomo sapiens--2.862024-03-0610.1038/s41421-024-00649-0
8ITMB1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ23.132023-10-1810.1073/pnas.2306145120
8ITM (No Gprot) B1PeptideGlucagonGIPHomo sapiens--3.132023-10-1810.1073/pnas.2306145120
8ITLB1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ23.232023-10-1810.1073/pnas.2306145120
8ITL (No Gprot) B1PeptideGlucagonGIPHomo sapiens--3.232023-10-1810.1073/pnas.2306145120
7RBTB1PeptideGlucagonGIPHomo sapiensTirzepatidePubChem 163183774chim(NtGi1-Gs)/β1/γ23.082022-04-1310.1073/pnas.2116506119
7RBT (No Gprot) B1PeptideGlucagonGIPHomo sapiensTirzepatidePubChem 1631837743.082022-04-1310.1073/pnas.2116506119
7RA3B1PeptideGlucagonGIPHomo sapiensGIP-chim(NtGi1-Gs)/β1/γ23.242022-04-1310.1073/pnas.2116506119
7RA3 (No Gprot) B1PeptideGlucagonGIPHomo sapiensGIP-3.242022-04-1310.1073/pnas.2116506119
7VABB1PeptideGlucagonGIPHomo sapiensNon-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ23.22022-03-0210.1038/s41467-022-28683-0
7VAB (No Gprot) B1PeptideGlucagonGIPHomo sapiensNon-Acylated Tirzepatide-3.22022-03-0210.1038/s41467-022-28683-0
7FIYB1PeptideGlucagonGIPHomo sapiensTirzepatide-Gs/β1/γ23.42022-03-0210.1038/s41467-022-28683-0
7FIY (No Gprot) B1PeptideGlucagonGIPHomo sapiensTirzepatide-3.42022-03-0210.1038/s41467-022-28683-0
7FINB1PeptideGlucagonGIPHomo sapiensPeptide-20; GGL-Gs/β1/γ23.12022-02-2310.1038/s41467-022-28683-0
7FIN (No Gprot) B1PeptideGlucagonGIPHomo sapiensPeptide-20; GGL-3.12022-02-2310.1038/s41467-022-28683-0
7DTYB1PeptideGlucagonGIPHomo sapiensGIP-Gs/β1/γ22.982021-08-0410.7554/eLife.68719
7DTY (No Gprot) B1PeptideGlucagonGIPHomo sapiensGIP-2.982021-08-0410.7554/eLife.68719




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8ITM.zip



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