Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:F127 8.644172
2R:R:Y141 10.6275497
3R:R:V143 2.0654185
4R:R:Y145 10.12497
5R:R:L152 5.52509
6R:R:R169 10.575659
7R:R:F180 7.97333668
8R:R:R183 5.518568
9R:R:R190 6.034596
10R:R:W233 10.094569
11R:R:L235 4.255408
12R:R:E237 6.3575459
13R:R:Y240 5.09429758
14R:R:H242 5.09254198
15R:R:G250 1.89406
16R:R:Y259 4.385408
17R:R:W264 6.22857769
18R:R:P267 5.162509
19R:R:W274 4.901676118
20R:R:R278 6.72754118
21R:R:W287 8.5025499
22R:R:K324 5.74254149
23R:R:R370 4.2925405
24R:R:F386 6.81254105
25R:R:V390 6.314105
26R:R:L391 4.10754107
27R:R:F394 5.6254108
28R:R:R405 7.755408
29R:R:R411 1.6654214
30A:A:Y37 9.08754224
31A:A:R42 8.16409
32A:A:D215 6.05754205
33A:A:F219 6.8325238
34A:A:F222 9.14537
35A:A:D223 4.0925409
36A:A:K233 7.058529
37A:A:W234 5.63409
38A:A:F238 6.45167639
39A:A:D240 7.5825436
40A:A:V247 3.5854247
41A:A:L270 5.83406
42A:A:F273 5.3925259
43A:A:W277 9.2145256
44A:A:W281 8.74535
45A:A:L289 5.57409
46A:A:N292 4.0885249
47A:A:Q294 4.462576
48A:A:P321 5.9425405
49A:A:E327 5.42714774
50A:A:D331 10.045404
51A:A:V334 5.425404
52A:A:K338 6.595475
53A:A:Y339 6.78573
54A:A:F340 9.3365157
55A:A:R342 6.7475474
56A:A:E344 8.3725155
57A:A:F345 8.7125408
58A:A:C359 3.9225405
59A:A:F363 8.5025475
60A:A:R373 3.78754205
61A:A:F376 6.54754208
62A:A:R385 65145
63A:A:Y391 9.284554
64B:B:I37 3.45754122
65B:B:V40 5.0125123
66B:B:R48 4.51417
67B:B:H54 9.046519
68B:B:K57 8.274539
69B:B:Y59 13.235438
70B:B:M61 4.492516
71B:B:W63 7.37617
72B:B:L70 7.185415
73B:B:V71 3.61408
74B:B:D76 7.515229
75B:B:K78 4.9725408
76B:B:W82 8.57719
77B:B:D83 7.196508
78B:B:K89 6.21833619
79B:B:I93 5.79407
80B:B:L95 4.954288
81B:B:W99 7.885839
82B:B:Y105 4.178506
83B:B:Y124 6.1375406
84B:B:E138 6.0575406
85B:B:L139 5.9325409
86B:B:H142 7.6654169
87B:B:Y145 6.14333628
88B:B:R150 4.0175406
89B:B:F151 4.392509
90B:B:C166 4.0475488
91B:B:W169 6.661437168
92B:B:Q176 7.61254164
93B:B:F180 6.844587
94B:B:H183 7.624509
95B:B:F199 6.884589
96B:B:V200 5.8725426
97B:B:K209 7.094586
98B:B:W211 9.164588
99B:B:F222 7.8225428
100B:B:H225 8.19333629
101B:B:D228 8.196529
102B:B:I232 4.0775428
103B:B:F235 5.83571746
104B:B:P236 6.39447
105B:B:N237 5.075405
106B:B:F241 6.51333626
107B:B:D247 8.264529
108B:B:R251 9.6025408
109B:B:F253 8.424526
110B:B:D254 3.455409
111B:B:R256 5.455409
112B:B:L261 4.1575405
113B:B:Y264 6.08167645
114B:B:H266 6.405444
115B:B:F278 4.966547
116B:B:R283 5.9356129
117B:B:L285 4.792546
118B:B:Y289 6.38833647
119B:B:C294 4.15254295
120B:B:N295 5.72446
121B:B:W297 5.29833648
122B:B:K301 4.8554125
123B:B:H311 8.6525139
124B:B:R314 12.368538
125B:B:T321 8.0325417
126B:B:D323 8.7525417
127B:B:V327 4.1775406
128B:B:W332 10.29639
129B:B:D333 7.15254139
130B:B:L336 4.232517
131B:B:K337 6.324136
132B:B:W339 6.2925139
133G:G:I9 7.84254262
134G:G:R27 5.248508
135G:G:Y40 9.005446
136G:G:D48 7.5375409
137G:G:L51 5.44754126
138G:G:N59 6.3675419
139G:G:F61 6.80167618
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:I187 R:R:R190 12.99986.26NoYes976
2R:R:A219 R:R:R190 21.3512.77NoYes066
3R:R:A219 R:R:S189 21.59281.71NoNo065
4R:R:A186 R:R:S189 22.55791.71NoNo065
5R:R:A186 R:R:V222 23.03913.39NoNo065
6R:R:L182 R:R:V222 23.51942.98NoNo075
7R:R:C226 R:R:L182 23.75934.76NoNo067
8R:R:C226 R:R:R183 23.99894.18NoYes068
9R:R:N230 R:R:R183 24.58298.44NoYes698
10R:R:N230 R:R:S179 33.66287.45NoNo699
11R:R:S179 R:R:W264 33.80324.94NoYes699
12R:R:W233 R:R:W264 36.155617.81YesYes699
13R:R:I172 R:R:W233 38.44414.7NoYes099
14R:R:I172 R:R:Y240 38.67054.84NoYes098
15R:R:T168 R:R:Y240 77.28153.75NoYes588
16R:R:F256 R:R:T168 77.69033.89NoNo058
17R:R:F256 R:R:Y171 77.87548.25NoNo056
18R:R:H166 R:R:Y171 78.060410.89NoNo076
19R:R:H166 R:R:R163 78.24516.77NoNo078
20B:B:R52 R:R:R163 78.42968.53NoNo078
21R:R:L244 R:R:Y240 30.27114.69NoYes088
22A:A:H387 R:R:L244 30.036815.43NoNo088
23A:A:H387 A:A:M386 22.672810.51NoNo083
24A:A:M386 A:A:R356 22.4324.96NoNo032
25A:A:R356 A:A:R389 22.19214.93NoNo024
26A:A:R389 A:A:Y358 21.95346.17NoNo044
27A:A:R385 A:A:Y358 20.71487.2YesNo1454
28A:A:D381 A:A:R385 13.76739.53NoYes1485
29B:B:F335 B:B:R52 78.10565.34NoNo047
30B:B:D333 B:B:F335 78.471810.75YesNo094
31B:B:D312 B:B:D333 85.30823.99NoYes059
32B:B:D312 R:R:R405 85.485614.29NoYes058
33R:R:H409 R:R:R405 86.016611.28NoYes078
34B:B:A309 R:R:H409 86.36954.39NoNo037
35B:B:N88 B:B:T86 26.09227.31NoNo076
36A:A:N23 B:B:N88 51.6759.54NoNo077
37A:A:N23 B:B:K89 51.88028.39NoYes079
38B:B:K89 B:B:W82 27.425512.76YesYes199
39B:B:L70 B:B:M61 19.1035.65YesYes156
40B:B:C317 B:B:M61 60.8344.86NoYes076
41B:B:C317 B:B:S316 60.97283.44NoNo079
42B:B:S316 B:B:W332 61.11374.94NoYes099
43B:B:R314 B:B:W332 10026.99YesYes389
44B:B:D290 B:B:R314 98.171813.1NoYes368
45B:B:C271 B:B:D290 98.32543.11NoNo056
46B:B:C271 B:B:D291 98.01186.22NoNo058
47B:B:D291 B:B:N293 86.721513.46NoNo085
48B:B:A309 B:B:N293 86.54563.13NoNo035
49A:A:Q19 B:B:N88 25.38259.24NoNo047
50B:B:D83 B:B:R68 42.268216.68YesNo085
51B:B:R68 B:B:Y85 43.485121.61NoNo054
52B:B:Y85 G:G:F61 43.946810.32NoYes148
53B:B:S84 G:G:F61 36.34765.28NoYes158
54B:B:S84 B:B:W63 18.28957.41NoYes157
55B:B:M61 B:B:W63 41.26066.98YesYes167
56B:B:I338 G:G:F61 18.14866.28NoYes058
57B:B:I338 B:B:W63 18.71794.7NoYes057
58B:B:L70 B:B:S84 18.476.01YesNo155
59A:A:Y37 B:B:D76 55.23023.45YesYes2249
60A:A:R42 A:A:Y37 55.785116.46YesYes094
61A:A:D240 A:A:N239 21.74394.04YesNo368
62A:A:N239 B:B:W332 21.82586.78NoYes389
63A:A:D240 B:B:K57 21.747412.44YesYes369
64B:B:K57 B:B:W332 42.3775.8YesYes399
65A:A:F222 A:A:R42 28.60046.41YesYes079
66A:A:D240 B:B:W99 46.17516.7YesYes369
67B:B:Q75 B:B:W99 40.96597.67NoYes399
68B:B:K57 B:B:Q75 20.5826.78YesNo399
69A:A:C237 B:B:W99 20.49935.22NoYes089
70A:A:C237 B:B:Y59 20.58068.06NoYes088
71B:B:W332 B:B:Y59 41.216511.58YesYes398
72B:B:Q75 B:B:Y59 20.580222.55NoYes398
73A:A:F238 B:B:W99 56.885913.03YesYes399
74A:A:N292 A:A:T364 10.25045.85YesNo099
75A:A:F290 A:A:T364 11.27079.08NoNo099
76A:A:D378 A:A:Y360 13.04436.9NoNo078
77A:A:D381 A:A:Y360 13.79410.34NoNo088
78A:A:Q227 B:B:N119 27.752310.56NoNo099
79A:A:Q227 A:A:W234 37.80594.38NoYes099
80A:A:F238 A:A:W234 87.59354.01YesYes099
81B:B:M101 B:B:Y145 55.6455.99NoYes098
82B:B:L117 B:B:M101 58.09234.24NoNo099
83B:B:L117 B:B:W99 49.14823.42NoYes399
84A:A:K233 B:B:D228 53.22598.3YesYes299
85A:A:K233 B:B:Y145 59.12623.58YesYes298
86A:A:R231 A:A:W234 51.94828NoYes099
87A:A:L272 A:A:R231 51.47888.5NoNo089
88A:A:F246 A:A:L272 51.06617.31NoNo098
89A:A:F246 A:A:L289 50.59586.09NoYes099
90A:A:F345 A:A:L289 20.27729.74YesYes089
91A:A:F363 A:A:R342 10.1978.55YesYes754
92A:A:P361 A:A:R342 17.8544.32NoYes754
93A:A:L289 A:A:P361 18.82233.28YesNo095
94A:A:F345 A:A:L270 13.15149.74YesYes086
95A:A:C359 A:A:L289 11.09913.17YesYes059
96G:G:E22 G:G:L19 14.57512.65NoNo099
97B:B:T221 G:G:E22 19.86875.64NoNo079
98B:B:K209 B:B:T221 23.830410.51YesNo067
99B:B:K209 B:B:W211 26.46446.96YesYes868
100B:B:F199 B:B:W211 30.395412.03YesYes898
101B:B:F199 B:B:L190 23.12196.09YesNo095
102B:B:L190 B:B:R150 30.38292.43NoYes056
103B:B:H62 B:B:R150 55.46295.64NoYes066
104B:B:H62 B:B:Y105 56.11392.18NoYes066
105B:B:L126 B:B:Y105 72.94863.52NoYes056
106B:B:I81 B:B:L126 89.35194.28NoNo075
107B:B:H91 B:B:I81 89.9943.98NoNo057
108B:B:H91 B:B:V90 90.63586.92NoNo055
109B:B:D83 B:B:V90 91.27742.92YesNo085
110B:B:F199 B:B:L192 23.12234.87YesNo095
111B:B:L192 B:B:R150 23.77792.43NoYes056
112B:B:D258 B:B:F222 10.89744.78NoYes278
113B:B:F222 B:B:F253 13.84658.57YesYes286
114B:B:F253 B:B:H225 28.65253.39YesYes269
115B:B:D247 B:B:H225 39.48633.78YesYes299
116B:B:D247 B:B:S227 49.33775.89YesNo296
117B:B:D228 B:B:S227 50.30775.89YesNo296
118B:B:W297 B:B:Y289 15.95535.79YesYes487
119B:B:D291 B:B:Y289 19.43194.6NoYes087
120B:B:H54 B:B:W82 27.73023.17YesYes199
121B:B:D76 B:B:S74 54.580310.31YesNo099
122B:B:L79 B:B:V71 25.16294.47NoYes078
123B:B:V71 B:B:Y105 15.34395.05YesYes086
124B:B:V112 B:B:V71 15.12553.21NoYes088
125B:B:L126 B:B:V112 15.78014.47NoNo058
126B:B:I93 B:B:L79 18.54325.71YesNo077
127B:B:I93 B:B:Y124 14.57374.84YesYes076
128B:B:H142 B:B:S161 22.934816.74YesNo099
129B:B:D163 B:B:S161 23.41757.36NoNo099
130B:B:D163 B:B:T143 25.346310.12NoNo095
131B:B:G144 B:B:T143 25.82793.64NoNo085
132B:B:G144 B:B:N119 26.30945.09NoNo089
133B:B:H142 B:B:W169 17.57146.35YesYes1698
134B:B:I171 B:B:L139 10.7814.28NoYes069
135B:B:L139 B:B:W169 14.177211.39YesYes098
136B:B:F180 B:B:T178 10.61056.49YesNo074
137B:B:F180 B:B:F199 13.21487.5YesYes879
138B:B:F241 B:B:F253 11.868710.72YesYes266
139A:A:R42 A:A:V241 21.78652.62YesNo099
140B:B:D83 B:B:T86 25.25115.78YesNo086
141A:A:Q19 B:B:D83 25.17226.53NoYes048
142B:B:I80 B:B:K89 26.30674.36NoYes189
143B:B:H54 B:B:I80 26.362813.26YesNo198
144B:B:H54 B:B:S74 54.459712.55YesNo099
145A:A:F222 A:A:F238 21.86963.22YesYes379
146A:A:F238 A:A:V241 21.63162.62YesNo099
147A:A:Q227 B:B:Y145 10.47165.64NoYes098
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8ITL
Class B1
SubFamily Peptide
Type Glucagon
SubType GIP
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.23
Date 2023-10-18
D.O.I. 10.1073/pnas.2306145120
Net Summary
Imin 3.11
Number of Linked Nodes 862
Number of Links 994
Number of Hubs 139
Number of Links mediated by Hubs 535
Number of Communities 29
Number of Nodes involved in Communities 192
Number of Links involved in Communities 253
Path Summary
Number Of Nodes in MetaPath 148
Number Of Links MetaPath 147
Number of Shortest Paths 1925942
Length Of Smallest Path 3
Average Path Length 33.8175
Length of Longest Path 75
Minimum Path Strength 1.265
Average Path Strength 7.15801
Maximum Path Strength 22.11
Minimum Path Correlation 0.71
Average Path Correlation 0.982251
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.38095
Average % Of Corr. Nodes 42.0216
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.0059
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP48546
Sequence
>8ITL_Chain_R
NEAFLDQRL ILERLQVMY TVGYSLSLA TLLLALLIL SLFRRLHCT 
RNYIHINLF TSFMLRAAA ILSRDRLLP NQALAACRT AQIVTQYCV 
GANYTWLLV EGVYLHSLL VLVGGSEEG HFRYYLLLG WGAPALFVI 
PWVIVRYLY ENTQCWERN EVKAIWWII RTPILMTIL INFLIFIRI 
LGILLSKLR TRQMRCRDY RLRLARSTL FLVPLLGVH EVVFAPVTE 
EQARGALRF AKLGFEIFL SSFQGFLVS VLYCFINKE VQSEIRRGW 
HHCRLRRS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8ITL_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGAGESGK 
NTIVKQMSG IFETKFQVD KVNFHMFDV GAQRDERRK WIQCFNDVT 
AIIFVVASS QTNRLQAAL KLFDSIWNN KWLRDTSVI LFLNKQDLL 
AEKVLAGKS KIEDYFPEF ARYTTPEDA TPEPGEDPR VTRAKYFIR 
DEFLRISTA SGDGRHYCY PHFTCAVDT ENIRRVFND CRDIIQRMH 
LRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>8ITL_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>8ITL_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7DTYB1PeptideGlucagonGIPHomo sapiensGIP-Gs/&β;1/&γ;22.982021-08-0410.7554/eLife.68719
7FINB1PeptideGlucagonGIPHomo sapiensPeptide-20; GGL-Gs/&β;1/&γ;23.12022-02-2310.1038/s41467-022-28683-0
7FIYB1PeptideGlucagonGIPHomo sapiensTirzepatide-Gs/&β;1/&γ;23.42022-03-0210.1038/s41467-022-28683-0
7RA3B1PeptideGlucagonGIPHomo sapiensGIP-chim(NtGi1-Gs)/&β;1/&γ;23.242022-04-1310.1073/pnas.2116506119
7RBTB1PeptideGlucagonGIPHomo sapiensTirzepatidePubChem 163183774chim(NtGi1-Gs)/&β;1/&γ;23.082022-04-1310.1073/pnas.2116506119
7VABB1PeptideGlucagonGIPHomo sapiensNon-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;23.22022-03-0210.1038/s41467-022-28683-0
8ITLB1PeptideGlucagonGIPHomo sapiens--Gs/&β;1/&γ;23.232023-10-1810.1073/pnas.2306145120
8ITMB1PeptideGlucagonGIPHomo sapiens--Gs/&β;1/&γ;23.132023-10-1810.1073/pnas.2306145120
8WA3B1PeptideGlucagonGIPHomo sapiens--Gs/&β;1/&γ;22.862024-03-0610.1038/s41421-024-00649-0




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8ITL.zip



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