psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?2	L:L:Y1	11.23	Yes	Yes	1	0	0
2	L:L:E3	L:L:Y1	3.37	Yes	Yes	1	0	0
3	L:L:G4	L:L:Y1	5.79	No	Yes	1	0	0
4	L:L:Y1	R:R:V227	16.4	Yes	No	0	0	6
5	L:L:Y1	R:R:Y231	3.97	Yes	Yes	1	0	8
6	L:L:Y1	R:R:W296	4.82	Yes	Yes	1	0	6
7	L:L:?2	L:L:E3	12.69	Yes	Yes	1	0	0
8	L:L:?2	L:L:G4	3.28	Yes	No	1	0	0
9	L:L:?2	R:R:E377	3.81	Yes	No	0	0	7
10	L:L:?2	R:R:I378	6.83	Yes	Yes	1	0	8
11	L:L:E3	R:R:Y145	8.98	Yes	Yes	1	0	7
12	L:L:E3	R:R:R183	4.65	Yes	Yes	1	0	8
13	L:L:E3	R:R:I187	8.2	Yes	No	0	0	7
14	L:L:E3	R:R:I378	4.1	Yes	Yes	1	0	8
15	L:L:E3	R:R:S381	8.62	Yes	No	1	0	5
16	L:L:D9	L:L:T5	4.34	No	No	0	0	0
17	L:L:F6	L:L:Y10	3.09	Yes	Yes	1	0	0
18	L:L:F6	R:R:L134	3.65	Yes	No	1	0	5
19	L:L:F6	R:R:L137	3.65	Yes	No	0	0	6
20	L:L:F6	R:R:Q138	4.68	Yes	No	1	0	5
21	L:L:F6	R:R:Y141	14.44	Yes	Yes	1	0	7
22	L:L:F6	R:R:L374	3.65	Yes	No	0	0	6
23	L:L:T7	R:R:R190	10.35	No	Yes	1	0	6
24	L:L:T7	R:R:D191	7.23	No	No	1	0	7
25	L:L:T7	R:R:E288	5.64	No	Yes	0	0	6
26	L:L:S8	R:R:N290	5.96	No	No	0	0	6
27	L:L:D9	R:R:R370	5.96	No	Yes	0	0	5
28	L:L:L14	L:L:Y10	8.21	No	Yes	0	0	0
29	L:L:Y10	R:R:L134	7.03	Yes	No	1	0	5
30	L:L:Y10	R:R:E135	6.73	Yes	No	0	0	3
31	L:L:S11	R:R:E288	5.75	No	Yes	0	0	6
32	L:L:S11	R:R:R289	6.59	No	No	0	0	4
33	L:L:?13	L:L:I12	6.83	No	No	0	0	0
34	L:L:I12	L:L:K16	4.36	No	No	0	0	0
35	L:L:I12	R:R:R289	8.77	No	No	0	0	4
36	L:L:?13	L:L:L14	3.98	No	No	0	0	0
37	L:L:?13	L:L:I17	4.1	No	No	0	0	0
38	L:L:D15	L:L:K16	4.15	Yes	No	0	0	0
39	L:L:D15	R:R:T31	7.23	Yes	No	0	0	5
40	L:L:D15	R:R:A32	3.09	Yes	No	0	0	4
41	L:L:D15	R:R:R289	4.76	Yes	No	0	0	4
42	L:L:I17	R:R:R131	3.76	No	No	0	0	3
43	L:L:Q19	R:R:A32	3.03	No	No	0	0	4
44	L:L:Q19	R:R:L35	10.65	No	No	0	0	5
45	L:L:K20	L:L:Q24	12.2	No	No	0	0	0
46	L:L:K20	R:R:L128	5.64	No	No	0	0	3
47	L:L:F22	L:L:V23	3.93	Yes	No	0	0	0
48	L:L:F22	L:L:L26	4.87	Yes	Yes	2	0	0
49	L:L:F22	R:R:L35	3.65	Yes	No	0	0	5
50	L:L:F22	R:R:Y36	6.19	Yes	Yes	2	0	3
51	L:L:F22	R:R:W39	5.01	Yes	Yes	2	0	6
52	L:L:F22	R:R:L201	7.31	Yes	No	2	0	2
53	L:L:S32	L:L:W25	3.71	No	No	0	0	0
54	L:L:W25	R:R:L201	4.56	No	No	0	0	2
55	L:L:L26	R:R:W39	6.83	Yes	Yes	2	0	6
56	L:L:L26	R:R:Y68	11.72	Yes	Yes	2	0	5
57	L:L:L26	R:R:Y87	5.86	Yes	Yes	2	0	4
58	L:L:I27	R:R:Y68	8.46	No	Yes	2	0	5
59	L:L:I27	R:R:R113	6.26	No	Yes	2	0	6
60	L:L:I27	R:R:H115	7.95	No	No	2	0	7
61	L:L:G30	L:L:P31	4.06	No	No	0	0	0
62	L:L:G30	R:R:M67	5.24	No	No	0	0	3
63	L:L:S32	R:R:Y200	5.09	No	No	0	0	4
64	R:R:P89	R:R:Q30	3.16	Yes	No	0	3	5
65	R:R:E34	R:R:T31	12.7	No	No	0	5	5
66	R:R:Q285	R:R:T31	5.67	No	No	0	3	5
67	R:R:E34	R:R:R38	9.3	No	No	0	5	5
68	R:R:L35	R:R:P89	9.85	No	Yes	0	5	3
69	R:R:L201	R:R:Y36	8.21	No	Yes	2	2	3
70	R:R:Q204	R:R:Y36	3.38	No	Yes	0	4	3
71	R:R:E40	R:R:Q37	12.74	No	No	0	3	4
72	R:R:Q204	R:R:Q37	7.68	No	No	0	4	4
73	R:R:R43	R:R:W39	7	Yes	Yes	0	4	6
74	R:R:M67	R:R:W39	6.98	No	Yes	0	3	6
75	R:R:W39	R:R:Y87	11.58	Yes	Yes	2	6	4
76	R:R:E40	R:R:R43	3.49	No	Yes	0	3	4
77	R:R:E40	R:R:R44	6.98	No	No	0	3	5
78	R:R:R41	R:R:R44	7.46	No	No	0	5	5
79	R:R:E45	R:R:R41	9.3	No	No	0	4	5
80	R:R:P85	R:R:Y42	5.56	No	Yes	2	8	7
81	R:R:W86	R:R:Y42	17.36	No	Yes	0	1	7
82	R:R:Y42	R:R:Y87	6.95	Yes	Yes	2	7	4
83	R:R:Q47	R:R:R43	5.84	No	Yes	0	3	4
84	R:R:F65	R:R:R43	6.41	No	Yes	0	7	4
85	R:R:C46	R:R:F65	4.19	No	No	0	8	7
86	R:R:C46	R:R:C70	7.28	No	No	0	8	9
87	R:R:C70	R:R:L50	3.17	No	No	0	9	4
88	R:R:E54	R:R:P55	3.14	No	No	0	2	2
89	R:R:A60	R:R:P56	3.74	No	No	0	4	1
90	R:R:D72	R:R:P56	4.83	No	No	0	6	1
91	R:R:G107	R:R:L59	3.42	No	No	0	9	1
92	R:R:C103	R:R:C61	7.28	No	No	2	9	9
93	R:R:C61	R:R:W109	14.37	No	Yes	2	9	9
94	R:R:G63	R:R:N62	3.39	No	No	0	4	4
95	R:R:D72	R:R:G63	5.03	No	No	0	6	4
96	R:R:S64	R:R:W71	7.41	No	Yes	2	6	9
97	R:R:S64	R:R:W109	9.88	No	Yes	2	6	9
98	R:R:D66	R:R:Y68	14.94	No	Yes	2	9	5
99	R:R:D66	R:R:V69	7.3	No	No	2	9	5
100	R:R:D66	R:R:W71	7.82	No	Yes	2	9	9
101	R:R:V69	R:R:Y68	8.83	No	Yes	2	5	5
102	R:R:Y68	R:R:Y87	6.95	Yes	Yes	2	5	4
103	R:R:R113	R:R:Y68	12.35	Yes	Yes	2	6	5
104	R:R:V69	R:R:W71	8.58	No	Yes	2	5	9
105	R:R:R101	R:R:W71	6	No	Yes	2	8	9
106	R:R:W109	R:R:W71	17.81	Yes	Yes	2	9	9
107	R:R:R113	R:R:W71	5	Yes	Yes	2	6	9
108	R:R:A74	R:R:C103	3.61	No	No	0	7	9
109	R:R:R81	R:R:T79	7.76	No	No	0	4	5
110	R:R:F98	R:R:R81	8.55	No	No	0	3	4
111	R:R:C84	R:R:G97	3.92	No	No	0	9	6
112	R:R:C118	R:R:C84	7.28	No	No	0	9	9
113	R:R:P85	R:R:Y87	8.34	No	Yes	2	8	4
114	R:R:H91	R:R:W86	5.29	No	No	0	5	1
115	R:R:L88	R:R:P89	4.93	No	Yes	4	5	3
116	R:R:L88	R:R:W90	5.69	No	Yes	4	5	4
117	R:R:P89	R:R:W90	20.27	Yes	Yes	4	3	4
118	R:R:N120	R:R:W90	15.82	No	Yes	4	3	4
119	R:R:P121	R:R:W90	4.05	Yes	Yes	4	2	4
120	R:R:H93	R:R:P121	10.68	No	Yes	0	4	2
121	R:R:P121	R:R:V94	5.3	Yes	No	0	2	3
122	R:R:G97	R:R:Q117	4.93	No	No	0	6	4
123	R:R:R101	R:R:W109	10	No	Yes	2	8	9
124	R:R:R101	R:R:R113	10.66	No	Yes	2	8	6
125	R:R:G110	R:R:Q102	4.93	No	No	0	3	4
126	R:R:Q102	R:R:W112	19.71	No	No	0	4	5
127	R:R:C103	R:R:W109	5.22	No	Yes	2	9	9
128	R:R:D106	R:R:Q108	7.83	No	No	0	5	5
129	R:R:Q108	R:R:W109	8.76	No	Yes	0	5	9
130	R:R:D114	R:R:W112	4.47	No	No	0	8	5
131	R:R:H115	R:R:R113	3.39	No	Yes	2	7	6
132	R:R:D114	R:R:T116	10.12	No	No	0	8	6
133	R:R:E119	R:R:H115	11.08	No	No	0	1	7
134	R:R:N120	R:R:P121	6.52	No	Yes	4	3	2
135	R:R:E122	R:R:N120	10.52	No	No	4	2	3
136	R:R:E122	R:R:E125	15.22	No	No	4	2	3
137	R:R:E122	R:R:F127	5.83	No	No	4	2	2
138	R:R:A126	R:R:N124	3.13	No	No	0	1	1
139	R:R:E125	R:R:F127	8.16	No	No	4	3	2
140	R:R:A126	R:R:D129	4.63	No	No	0	1	1
141	R:R:Q130	R:R:R370	9.35	No	Yes	0	3	5
142	R:R:L132	R:R:R131	3.64	No	No	0	3	3
143	R:R:E135	R:R:R131	8.14	No	No	0	3	3
144	R:R:I133	R:R:R370	3.76	No	Yes	0	4	5
145	R:R:L134	R:R:R370	3.64	No	Yes	0	5	5
146	R:R:Q138	R:R:Y141	10.15	No	Yes	1	5	7
147	R:R:I378	R:R:M140	4.37	Yes	No	0	8	6
148	R:R:F379	R:R:M140	4.98	No	No	0	6	6
149	R:R:Y141	R:R:Y145	5.96	Yes	Yes	1	7	7
150	R:R:D191	R:R:Y141	6.9	No	Yes	1	7	7
151	R:R:I378	R:R:Y141	3.63	Yes	Yes	1	8	7
152	R:R:L188	R:R:T142	5.9	No	No	0	7	7
153	R:R:F383	R:R:G144	7.53	Yes	No	0	6	8
154	R:R:R183	R:R:Y145	3.09	Yes	Yes	1	8	7
155	R:R:A184	R:R:Y145	4	No	Yes	0	8	7
156	R:R:S382	R:R:Y145	5.09	No	Yes	0	9	7
157	R:R:F386	R:R:L147	13.4	No	No	0	5	5
158	R:R:G385	R:R:S148	3.71	No	No	0	9	9
159	R:R:L149	R:R:M181	5.65	No	No	0	6	7
160	R:R:A184	R:R:L149	4.73	No	No	0	8	6
161	R:R:F386	R:R:T151	7.78	No	No	0	5	7
162	R:R:S389	R:R:T151	4.8	Yes	No	0	8	7
163	R:R:F177	R:R:L152	7.31	Yes	Yes	5	9	9
164	R:R:F180	R:R:L152	6.09	Yes	Yes	0	8	9
165	R:R:L152	R:R:M181	4.24	Yes	No	0	9	7
166	R:R:L152	R:R:S389	4.5	Yes	Yes	5	9	8
167	R:R:L153	R:R:M181	4.24	No	No	0	3	7
168	R:R:A155	R:R:F177	4.16	No	Yes	5	9	9
169	R:R:A155	R:R:S389	3.42	No	Yes	5	9	8
170	R:R:A155	R:R:C393	3.61	No	No	0	9	9
171	R:R:I174	R:R:L156	5.71	No	No	0	7	6
172	R:R:F177	R:R:L156	8.53	Yes	No	0	9	6
173	R:R:C393	R:R:I158	3.27	No	No	0	9	8
174	R:R:L159	R:R:N170	8.24	No	No	0	8	9
175	R:R:I174	R:R:L159	8.56	No	No	0	7	8
176	R:R:E402	R:R:F162	15.16	No	No	0	8	7
177	R:R:R164	R:R:R405	8.53	No	Yes	0	7	8
178	R:R:L165	R:R:N170	6.87	No	No	0	9	9
179	R:R:H166	R:R:Y171	11.98	No	No	0	7	6
180	R:R:C167	R:R:R169	4.18	No	Yes	0	8	9
181	R:R:I172	R:R:T168	3.04	Yes	Yes	3	9	8
182	R:R:T168	R:R:Y240	9.99	Yes	Yes	3	8	8
183	R:R:F256	R:R:T168	5.19	Yes	Yes	3	5	8
184	R:R:T168	R:R:Y259	3.75	Yes	Yes	3	8	8
185	R:R:N170	R:R:R169	15.67	No	Yes	0	9	9
186	R:R:H173	R:R:R169	3.39	Yes	Yes	0	9	9
187	R:R:R169	R:R:Y240	4.12	Yes	Yes	0	9	8
188	R:R:E398	R:R:R169	11.63	No	Yes	0	9	9
189	R:R:E253	R:R:Y171	6.73	No	No	3	5	6
190	R:R:F256	R:R:Y171	9.28	Yes	No	3	5	6
191	R:R:E237	R:R:I172	4.1	Yes	Yes	3	9	9
192	R:R:I172	R:R:Y240	9.67	Yes	Yes	3	9	8
193	R:R:I172	R:R:Y259	7.25	Yes	Yes	3	9	8
194	R:R:E237	R:R:H173	12.31	Yes	Yes	3	9	9
195	R:R:H173	R:R:L349	3.86	Yes	No	3	9	9
196	R:R:H173	R:R:Y392	5.44	Yes	No	3	9	8
197	R:R:N175	R:R:W233	28.25	No	Yes	6	9	9
198	R:R:N175	R:R:W264	10.17	No	Yes	6	9	9
199	R:R:F180	R:R:L176	4.87	Yes	No	0	8	9
200	R:R:L176	R:R:L234	5.54	No	No	0	9	9
201	R:R:E237	R:R:L176	5.3	Yes	No	0	9	9
202	R:R:F177	R:R:S389	3.96	Yes	Yes	5	9	8
203	R:R:T178	R:R:W264	3.64	No	Yes	0	3	9
204	R:R:N230	R:R:S179	7.45	No	No	0	9	9
205	R:R:S179	R:R:W233	6.18	No	Yes	0	9	9
206	R:R:F180	R:R:N230	14.5	Yes	No	0	8	9
207	R:R:F180	R:R:G385	4.52	Yes	No	0	8	9
208	R:R:F180	R:R:V388	10.49	Yes	No	0	8	9
209	R:R:C226	R:R:L182	11.11	No	No	0	6	7
210	R:R:R183	R:R:V227	9.15	Yes	No	0	8	6
211	R:R:N230	R:R:R183	13.26	No	Yes	0	9	8
212	R:R:R183	R:R:Y231	6.17	Yes	Yes	1	8	8
213	R:R:R183	R:R:S381	3.95	Yes	No	1	8	5
214	R:R:A186	R:R:T223	3.36	No	No	0	6	6
215	R:R:A186	R:R:C226	3.61	No	No	0	6	6
216	R:R:I187	R:R:T223	6.08	No	No	0	7	6
217	R:R:I187	R:R:V227	3.07	No	No	0	7	6
218	R:R:D191	R:R:R190	14.29	No	Yes	1	7	6
219	R:R:Q220	R:R:R190	23.36	No	Yes	0	5	6
220	R:R:R190	R:R:T223	11.64	Yes	No	0	6	6
221	R:R:L193	R:R:L194	4.15	No	Yes	0	5	7
222	R:R:L194	R:R:P195	3.28	Yes	No	7	7	3
223	R:R:C216	R:R:L194	4.76	No	Yes	7	9	7
224	R:R:A219	R:R:L194	4.73	No	Yes	0	6	7
225	R:R:C216	R:R:P195	5.65	No	No	7	9	3
226	R:R:E288	R:R:P195	9.43	Yes	No	0	6	3
227	R:R:R196	R:R:W209	5	No	No	0	3	4
228	R:R:A212	R:R:R196	5.53	No	No	0	6	3
229	R:R:G198	R:R:P199	4.06	No	No	0	3	3
230	R:R:P199	R:R:W209	4.05	No	No	0	3	4
231	R:R:L206	R:R:W209	6.83	No	No	0	1	4
232	R:R:L213	R:R:R217	12.15	No	No	0	4	8
233	R:R:C216	R:R:C286	7.28	No	No	0	9	9
234	R:R:N283	R:R:R217	7.23	No	No	1	6	8
235	R:R:R217	R:R:W287	24.99	No	Yes	1	8	9
236	R:R:E288	R:R:Q220	10.19	Yes	No	0	6	5
237	R:R:I221	R:R:V271	3.07	Yes	No	0	5	6
238	R:R:I221	R:R:W274	3.52	Yes	Yes	1	5	8
239	R:R:I221	R:R:V275	6.14	Yes	No	0	5	6
240	R:R:I221	R:R:W287	3.52	Yes	Yes	1	5	9
241	R:R:Q224	R:R:W274	23	No	Yes	1	6	8
242	R:R:Q224	R:R:W296	4.38	No	Yes	1	6	6
243	R:R:I299	R:R:Q224	8.23	Yes	No	1	7	6
244	R:R:P267	R:R:Y225	9.74	Yes	No	0	9	8
245	R:R:F270	R:R:G228	4.52	No	No	0	5	5
246	R:R:A229	R:R:P267	3.74	No	Yes	0	8	9
247	R:R:I303	R:R:Y231	12.09	No	Yes	0	7	8
248	R:R:T306	R:R:Y231	3.75	No	Yes	0	7	8
249	R:R:I307	R:R:Y231	3.63	No	Yes	1	7	8
250	R:R:E354	R:R:Y231	4.49	No	Yes	1	7	8
251	R:R:G263	R:R:T232	3.64	No	No	0	9	6
252	R:R:A266	R:R:T232	3.36	No	No	0	4	6
253	R:R:P267	R:R:T232	3.5	Yes	No	0	9	6
254	R:R:V236	R:R:W233	8.58	No	Yes	0	8	9
255	R:R:L260	R:R:W233	5.69	No	Yes	6	6	9
256	R:R:G263	R:R:W233	7.04	No	Yes	0	9	9
257	R:R:W233	R:R:W264	22.49	Yes	Yes	6	9	9
258	R:R:L235	R:R:T306	7.37	No	No	0	8	7
259	R:R:V236	R:R:Y259	3.79	No	Yes	0	8	8
260	R:R:E237	R:R:L349	11.93	Yes	No	3	9	9
261	R:R:G238	R:R:N310	5.09	No	No	0	9	9
262	R:R:L244	R:R:Y240	8.21	No	Yes	3	8	8
263	R:R:Y240	R:R:Y259	6.95	Yes	Yes	3	8	8
264	R:R:L241	R:R:L245	4.15	No	No	3	9	8
265	R:R:I317	R:R:L241	7.14	No	No	0	9	9
266	R:R:H242	R:R:V246	13.84	No	No	0	8	7
267	R:R:H242	R:R:I313	7.95	No	No	0	8	8
268	R:R:I320	R:R:L245	5.71	No	No	0	8	8
269	R:R:E252	R:R:H255	14.77	No	No	0	7	4
270	R:R:E253	R:R:F256	11.66	No	Yes	3	5	5
271	R:R:H255	R:R:Y258	3.27	No	No	0	4	3
272	R:R:F256	R:R:Y259	3.09	Yes	Yes	3	5	8
273	R:R:L262	R:R:Y258	4.69	No	No	0	6	3
274	R:R:L260	R:R:W264	3.42	No	Yes	6	6	9
275	R:R:F270	R:R:I299	5.02	No	Yes	0	5	7
276	R:R:F270	R:R:P302	20.23	No	No	0	5	9
277	R:R:I272	R:R:P273	3.39	No	No	0	2	4
278	R:R:R278	R:R:W274	12	Yes	Yes	1	8	8
279	R:R:W274	R:R:W287	3.75	Yes	Yes	1	8	9
280	R:R:I298	R:R:W274	4.7	No	Yes	0	8	8
281	R:R:I299	R:R:W274	5.87	Yes	Yes	1	7	8
282	R:R:V277	R:R:Y281	5.05	No	No	0	5	3
283	R:R:I295	R:R:V277	7.68	No	No	0	3	5
284	R:R:E282	R:R:R278	5.82	No	Yes	1	5	8
285	R:R:R278	R:R:T284	5.17	Yes	No	1	8	4
286	R:R:R278	R:R:W287	18.99	Yes	Yes	1	8	9
287	R:R:L280	R:R:Y281	9.38	No	No	0	3	3
288	R:R:E282	R:R:T284	5.64	No	No	1	5	4
289	R:R:E282	R:R:V292	5.7	No	Yes	0	5	6
290	R:R:N283	R:R:W287	9.04	No	Yes	1	6	9
291	R:R:C286	R:R:E288	6.08	No	Yes	0	9	6
292	R:R:N290	R:R:W296	9.04	No	Yes	0	6	6
293	R:R:E291	R:R:V292	4.28	No	Yes	0	4	6
294	R:R:I295	R:R:V292	7.68	No	Yes	0	3	6
295	R:R:I299	R:R:W296	3.52	Yes	Yes	1	7	6
296	R:R:R300	R:R:W296	15.99	No	Yes	0	7	6
297	R:R:R300	R:R:W297	8	No	No	0	7	7
298	R:R:I303	R:R:R300	5.01	No	No	0	7	7
299	R:R:P302	R:R:T301	3.5	No	No	0	9	4
300	R:R:E354	R:R:I307	4.1	No	No	1	7	7
301	R:R:I307	R:R:V355	3.07	No	No	0	7	5
302	R:R:L350	R:R:N310	15.1	No	No	0	9	9
303	R:R:F311	R:R:I315	5.02	No	No	0	6	5
304	R:R:F311	R:R:V352	5.24	No	No	0	6	6
305	R:R:F311	R:R:V355	9.18	No	No	0	6	5
306	R:R:F314	R:R:L346	6.09	Yes	No	8	9	9
307	R:R:F314	R:R:L350	3.65	Yes	No	8	9	9
308	R:R:F314	R:R:V352	14.42	Yes	No	0	9	6
309	R:R:L318	R:R:T343	5.9	No	Yes	0	7	9
310	R:R:L321	R:R:L325	4.15	No	No	0	9	7
311	R:R:L321	R:R:S342	4.5	No	No	0	9	9
312	R:R:L322	R:R:R326	6.07	Yes	No	9	5	7
313	R:R:L322	R:R:Y335	7.03	Yes	Yes	9	5	5
314	R:R:L322	R:R:L339	4.15	Yes	No	0	5	9
315	R:R:L325	R:R:R338	6.07	No	No	0	7	9
316	R:R:R326	R:R:Y335	10.29	No	Yes	9	7	5
317	R:R:R338	R:R:R341	9.6	No	No	0	9	9
318	R:R:S342	R:R:T343	3.2	No	Yes	0	9	9
319	R:R:L346	R:R:L350	5.54	No	No	8	9	9
320	R:R:P348	R:R:V347	5.3	Yes	No	1	9	8
321	R:R:V347	R:R:V352	3.21	No	No	0	8	6
322	R:R:V347	W:W:?1	17.7	No	Yes	1	8	0
323	R:R:L387	R:R:P348	8.21	No	Yes	1	6	9
324	R:R:P348	R:R:V388	3.53	Yes	No	0	9	9
325	R:R:P348	W:W:?1	9.76	Yes	Yes	1	9	0
326	R:R:L349	R:R:Y392	15.24	No	No	3	9	8
327	R:R:G351	R:R:H353	3.18	No	Yes	1	9	8
328	R:R:G351	R:R:Q384	3.29	No	No	1	9	9
329	R:R:E354	R:R:H353	3.69	No	Yes	1	7	8
330	R:R:H353	R:R:L380	9	Yes	No	1	8	7
331	R:R:H353	R:R:Q384	14.84	Yes	No	1	8	9
332	R:R:H353	W:W:?1	17.19	Yes	Yes	1	8	0
333	R:R:F357	R:R:V356	9.18	No	No	0	7	6
334	R:R:V356	W:W:?1	5.53	No	Yes	0	6	0
335	R:R:E377	R:R:F357	15.16	No	No	0	7	7
336	R:R:K373	R:R:V360	7.59	No	No	0	7	4
337	R:R:Q364	R:R:R366	5.84	No	No	0	5	5
338	R:R:L369	R:R:R366	4.86	No	No	0	4	5
339	R:R:L369	R:R:R370	6.07	No	Yes	0	4	5
340	R:R:F371	R:R:F376	4.29	No	No	0	4	4
341	R:R:F379	R:R:F383	12.86	No	Yes	0	6	6
342	R:R:L380	W:W:?1	15.42	No	Yes	1	7	0
343	R:R:F383	R:R:S382	6.61	Yes	No	0	6	9
344	R:R:F383	W:W:?1	3.62	Yes	Yes	0	6	0
345	R:R:Q384	W:W:?1	6.92	No	Yes	1	9	0
346	R:R:F386	R:R:V390	6.55	No	No	0	5	5
347	R:R:L387	R:R:L391	6.92	No	No	0	6	7
348	R:R:L387	W:W:?1	14.39	No	Yes	1	6	0
349	R:R:F394	R:R:V390	3.93	No	No	0	8	5
350	R:R:C393	R:R:F394	5.59	No	No	0	9	8
351	R:R:E398	R:R:N396	10.52	No	No	0	9	9
352	R:R:N396	R:R:V399	4.43	No	No	0	9	9
353	R:R:E402	R:R:R405	5.82	No	Yes	0	8	8
354	R:R:R404	R:R:W407	7	No	No	10	6	5
355	R:R:H408	R:R:R404	3.39	No	No	10	4	6
356	R:R:G406	R:R:R405	9.01	No	Yes	0	5	8
357	R:R:H409	R:R:R405	3.39	No	Yes	0	7	8
358	R:R:H408	R:R:W407	6.35	No	No	10	4	5
359	R:R:F371	R:R:G375	3.01	No	No	0	4	5
360	R:R:L100	R:R:T116	2.95	No	No	0	4	6
361	R:R:L391	R:R:T345	2.95	No	No	0	7	8
362	R:R:I313	R:R:I317	2.94	No	No	0	8	9
363	L:L:I17	L:L:K20	2.91	No	No	0	0	0
364	R:R:G33	R:R:Y36	2.9	No	Yes	0	5	3
365	R:R:I309	R:R:L235	2.85	No	No	0	6	8
366	R:R:I315	R:R:L312	2.85	No	No	0	5	4
367	R:R:K373	R:R:L369	2.82	No	No	0	7	4
368	R:R:L153	R:R:L157	2.77	No	No	0	3	1
369	R:R:L241	R:R:L244	2.77	No	No	3	9	8
370	R:R:L244	R:R:L245	2.77	No	No	3	8	8
371	R:R:L308	R:R:L312	2.77	No	No	0	3	4
372	R:R:L318	R:R:L339	2.77	No	No	0	7	9
373	R:R:L208	R:R:N210	2.75	No	No	0	4	4
374	R:R:E402	R:R:I403	2.73	No	No	0	8	5
375	R:R:K397	R:R:Q400	2.71	No	No	0	5	8
376	R:R:A268	R:R:Y225	2.67	No	No	0	3	8
377	R:R:A82	R:R:W71	2.59	No	Yes	0	5	9
378	R:R:F314	R:R:T343	2.59	Yes	Yes	0	9	9
379	R:R:R341	R:R:T345	2.59	No	No	0	9	8
380	R:R:S251	R:R:Y259	2.54	No	Yes	0	7	8
381	R:R:I315	R:R:R316	2.51	No	No	0	5	8
382	R:R:V99	R:R:W71	2.45	No	Yes	0	7	9
383	R:R:F162	R:R:L161	2.44	No	No	0	7	3
384	R:R:H92	R:R:H93	2.39	No	No	0	5	4
385	L:L:G29	L:L:G30	2.11	No	No	0	0	0
386	R:R:G249	R:R:G250	2.11	No	No	0	7	6
387	R:R:G265	R:R:P267	2.03	No	Yes	0	6	9
388	R:R:P55	R:R:P56	1.95	No	No	0	2	1
389	R:R:C84	R:R:P85	1.88	No	No	0	9	8
390	R:R:A75	R:R:P76	1.87	No	No	0	2	4
391	R:R:A358	R:R:P359	1.87	No	No	0	6	5
392	R:R:G144	R:R:V143	1.84	No	No	0	8	5
393	L:L:A18	R:R:A32	1.79	No	No	0	0	4
394	R:R:A74	R:R:A80	1.79	No	No	0	7	6
395	R:R:A75	R:R:A78	1.79	No	No	0	2	5
396	R:R:A368	R:R:A372	1.79	No	No	0	1	5
397	R:R:G375	R:R:L137	1.71	No	No	0	5	6
398	R:R:C226	R:R:V222	1.71	No	No	0	6	5
399	R:R:G263	R:R:L262	1.71	No	No	0	9	6
400	R:R:G319	R:R:L322	1.71	No	Yes	0	8	5
401	R:R:G375	R:R:L374	1.71	No	No	0	5	6
402	R:R:A294	R:R:V292	1.7	No	Yes	0	3	6
403	R:R:D106	R:R:G104	1.68	No	No	0	5	4
404	R:R:D106	R:R:G107	1.68	No	No	0	5	9
405	L:L:L14	R:R:P197	1.64	No	No	0	0	4
406	R:R:E34	R:R:G29	1.64	No	No	0	5	4
407	R:R:S243	R:R:S251	1.63	No	No	0	7	7
408	R:R:A215	R:R:L194	1.58	No	Yes	0	3	7
409	R:R:A358	R:R:L304	1.58	No	No	0	6	4
410	R:R:I174	R:R:S160	1.55	No	No	0	7	3
411	R:R:I276	R:R:V277	1.54	No	No	0	3	5
412	R:R:F98	R:R:G97	1.51	No	No	0	3	6
413	R:R:M305	R:R:T301	1.51	No	No	0	4	4
414	R:R:L161	R:R:S160	1.5	No	No	0	3	3
415	R:R:L247	R:R:S243	1.5	No	No	0	5	7
416	R:R:G367	R:R:R366	1.5	No	No	0	4	5
417	R:R:N77	R:R:S105	1.49	No	No	0	7	1
418	R:R:L235	R:R:V239	1.49	No	No	0	8	7
419	R:R:L50	R:R:T49	1.47	No	No	0	4	3
420	R:R:I272	R:R:I276	1.47	No	No	0	2	3
421	R:R:L344	R:R:T343	1.47	No	Yes	0	8	9
422	R:R:I320	R:R:K324	1.45	No	No	0	8	9
423	R:R:P197	R:R:R196	1.44	No	No	0	4	3
424	R:R:E398	R:R:S401	1.44	No	No	0	9	4
425	R:R:Q102	R:R:T79	1.42	No	No	0	4	5
426	R:R:Q364	R:R:T361	1.42	No	No	0	5	7
427	R:R:G63	R:R:W109	1.41	No	Yes	0	4	9
428	R:R:L304	R:R:M305	1.41	No	No	0	4	4
429	R:R:L149	R:R:L188	1.38	No	No	0	6	7
430	R:R:L261	R:R:L262	1.38	No	No	0	3	6
431	R:R:D334	R:R:L337	1.36	No	No	0	6	7
432	R:R:R190	R:R:S189	1.32	Yes	No	0	6	5
433	R:R:D129	R:R:Q130	1.31	No	No	0	1	3
434	R:R:R326	R:R:T327	1.29	No	No	0	7	6
435	R:R:S83	R:R:Y42	1.27	No	Yes	0	3	7
436	R:R:I395	R:R:R341	1.25	No	No	0	5	9
437	R:R:L193	R:R:R192	1.21	No	No	0	5	4
438	R:R:N283	R:R:Y279	1.16	No	No	0	6	3
439	R:R:D334	R:R:Y335	1.15	No	Yes	0	6	5
440	R:R:L111	R:R:W112	1.14	No	No	0	5	5
441	R:R:H166	R:R:R163	1.13	No	No	0	7	8
442	R:R:R336	R:R:Y335	1.03	No	Yes	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Y1	7.59667	6	1	0
2	L:L:?2	7.568	5	1	0
3	L:L:E3	7.23	7	1	0
4	L:L:F6	5.52667	6	1	0
5	L:L:Y10	6.265	4	1	0
6	L:L:D15	4.8075	4	0	0
7	L:L:F22	5.16	6	2	0
8	L:L:L26	7.32	4	2	0
9	R:R:Y36	5.17	4	2	3
10	R:R:W39	7.48	5	2	6
11	R:R:Y42	7.785	4	2	7
12	R:R:R43	5.685	4	0	4
13	R:R:Y68	10.5417	6	2	5
14	R:R:W71	7.2075	8	2	9
15	R:R:Y87	7.936	5	2	4
16	R:R:P89	9.5525	4	4	3
17	R:R:W90	11.4575	4	4	4
18	R:R:W109	9.63571	7	2	9
19	R:R:R113	7.532	5	2	6
20	R:R:P121	6.6375	4	4	2
21	R:R:Y141	8.216	5	1	7
22	R:R:Y145	5.424	5	1	7
23	R:R:L152	5.535	4	5	9
24	R:R:T168	5.4925	4	3	8
25	R:R:R169	7.798	5	0	9
26	R:R:I172	6.015	4	3	9
27	R:R:H173	6.25	4	3	9
28	R:R:F177	5.99	4	5	9
29	R:R:F180	8.094	5	0	8
30	R:R:R183	6.71167	6	1	8
31	R:R:R190	12.192	5	1	6
32	R:R:L194	3.7	5	7	7
33	R:R:I221	4.0625	4	1	5
34	R:R:Y231	5.68333	6	1	8
35	R:R:W233	13.0383	6	6	9
36	R:R:E237	8.41	4	3	9
37	R:R:Y240	7.788	5	3	8
38	R:R:F256	7.305	4	3	5
39	R:R:Y259	4.56167	6	3	8
40	R:R:W264	9.93	4	6	9
41	R:R:P267	4.7525	4	0	9
42	R:R:W274	8.80667	6	1	8
43	R:R:R278	10.495	4	1	8
44	R:R:W287	12.058	5	1	9
45	R:R:E288	7.418	5	0	6
46	R:R:V292	4.84	4	0	6
47	R:R:W296	7.55	5	1	6
48	R:R:I299	5.66	4	1	7
49	R:R:F314	6.6875	4	8	9
50	R:R:L322	4.74	4	9	5
51	R:R:Y335	4.875	4	9	5
52	R:R:T343	3.29	4	0	9
53	R:R:P348	6.7	4	1	9
54	R:R:H353	9.58	5	1	8
55	R:R:R370	5.756	5	0	5
56	R:R:I378	4.7325	4	1	8
57	R:R:F383	7.655	4	0	6
58	R:R:S389	4.17	4	5	8
59	R:R:R405	6.6875	4	0	8
60	W:W:?1	11.3162	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?2	L:L:Y1	11.62	11.23	Yes	Yes	1	0	0
2	L:L:Y1	R:R:V227	22.9538	16.4	Yes	No	0	0	6
3	L:L:Y1	R:R:W296	85.2823	4.82	Yes	Yes	1	0	6
4	L:L:E3	R:R:Y145	12.473	8.98	Yes	Yes	1	0	7
5	L:L:E3	R:R:I187	20.1012	8.2	Yes	No	0	0	7
6	L:L:?2	R:R:I378	12.3173	6.83	Yes	Yes	1	0	8
7	R:R:I378	R:R:Y141	24.3246	3.63	Yes	Yes	1	8	7
8	L:L:F6	R:R:Y141	14.7065	14.44	Yes	Yes	1	0	7
9	R:R:D191	R:R:Y141	57.6423	6.9	No	Yes	1	7	7
10	L:L:T7	R:R:D191	56.7349	7.23	No	No	1	0	7
11	R:R:I187	R:R:T223	39.4216	6.08	No	No	0	7	6
12	R:R:R190	R:R:T223	39.1049	11.64	Yes	No	0	6	6
13	L:L:T7	R:R:E288	75.8184	5.64	No	Yes	0	0	6
14	L:L:L14	L:L:Y10	12.3352	8.21	No	Yes	0	0	0
15	L:L:S11	R:R:E288	91.5419	5.75	No	Yes	0	0	6
16	L:L:S11	R:R:R289	91.1805	6.59	No	No	0	0	4
17	L:L:?13	L:L:L14	12.0014	3.98	No	No	0	0	0
18	L:L:?13	L:L:I12	12.6242	6.83	No	No	0	0	0
19	L:L:D15	R:R:R289	96.5588	4.76	Yes	No	0	0	4
20	L:L:D15	R:R:A32	100	3.09	Yes	No	0	0	4
21	L:L:Q19	R:R:A32	99.0985	3.03	No	No	0	0	4
22	L:L:Q19	R:R:L35	98.6456	10.65	No	No	0	0	5
23	L:L:F22	R:R:L35	92.6214	3.65	Yes	No	0	0	5
24	L:L:F22	L:L:L26	66.2942	4.87	Yes	Yes	2	0	0
25	L:L:F22	R:R:W39	21.4631	5.01	Yes	Yes	2	0	6
26	L:L:L26	R:R:Y68	54.9648	11.72	Yes	Yes	2	0	5
27	L:L:L26	R:R:Y87	11.9463	5.86	Yes	Yes	2	0	4
28	R:R:W39	R:R:Y87	13.3231	11.58	Yes	Yes	2	6	4
29	R:R:R113	R:R:Y68	26.8391	12.35	Yes	Yes	2	6	5
30	R:R:P85	R:R:Y87	19.12	8.34	No	Yes	2	8	4
31	R:R:D66	R:R:Y68	14.0599	14.94	No	Yes	2	9	5
32	R:R:D66	R:R:W71	13.4326	7.82	No	Yes	2	9	9
33	R:R:W109	R:R:W71	32.7135	17.81	Yes	Yes	2	9	9
34	R:R:G63	R:R:W109	18.0278	1.41	No	Yes	0	4	9
35	R:R:D72	R:R:G63	12.8842	5.03	No	No	0	6	4
36	R:R:D72	R:R:P56	10.3102	4.83	No	No	0	6	1
37	R:R:V69	R:R:Y68	14.0628	8.83	No	Yes	2	5	5
38	R:R:V69	R:R:W71	13.4378	8.58	No	Yes	2	5	9
39	R:R:R113	R:R:W71	13.4788	5	Yes	Yes	2	6	9
40	R:R:R101	R:R:R113	11.5589	10.66	No	Yes	2	8	6
41	R:R:R101	R:R:W109	10.9301	10	No	Yes	2	8	9
42	R:R:Q108	R:R:W109	12.8842	8.76	No	Yes	0	5	9
43	R:R:D106	R:R:Q108	10.3102	7.83	No	No	0	5	5
44	R:R:C84	R:R:P85	17.8974	1.88	No	No	0	9	8
45	R:R:C84	R:R:G97	15.3584	3.92	No	No	0	9	6
46	R:R:F98	R:R:G97	12.8135	1.51	No	No	0	3	6
47	R:R:F98	R:R:R81	11.5387	8.55	No	No	0	3	4
48	R:R:R81	R:R:T79	10.2625	7.76	No	No	0	4	5
49	R:R:N230	R:R:R183	35.064	13.26	No	Yes	0	9	8
50	R:R:F180	R:R:N230	21.4645	14.5	Yes	No	0	8	9
51	R:R:F180	R:R:L152	11.7518	6.09	Yes	Yes	0	8	9
52	R:R:F177	R:R:L152	10.2126	7.31	Yes	Yes	5	9	9
53	R:R:F180	R:R:L176	11.6363	4.87	Yes	No	0	8	9
54	R:R:E237	R:R:L176	10.8429	5.3	Yes	No	0	9	9
55	R:R:N230	R:R:S179	15.4441	7.45	No	No	0	9	9
56	R:R:S179	R:R:W233	15.0589	6.18	No	Yes	0	9	9
57	R:R:Q220	R:R:R190	19.7369	23.36	No	Yes	0	5	6
58	R:R:Q224	R:R:W296	33.8645	4.38	No	Yes	1	6	6
59	R:R:Q224	R:R:W274	32.4706	23	No	Yes	1	6	8
60	R:R:W274	R:R:W287	14.1545	3.75	Yes	Yes	1	8	9
61	R:R:I299	R:R:W296	45.153	3.52	Yes	Yes	1	7	6
62	R:R:I299	R:R:W274	32.6077	5.87	Yes	Yes	1	7	8
63	R:R:F270	R:R:I299	11.4367	5.02	No	Yes	0	5	7
64	R:R:R278	R:R:W274	36.8319	12	Yes	Yes	1	8	8
65	R:R:E282	R:R:R278	31.2391	5.82	No	Yes	1	5	8
66	R:R:E282	R:R:V292	28.414	5.7	No	Yes	0	5	6
67	R:R:I295	R:R:V292	19.9052	7.68	No	Yes	0	3	6
68	R:R:I295	R:R:V277	17.066	7.68	No	No	0	3	5
69	L:L:E3	L:L:Y1	46.1617	3.37	Yes	Yes	1	0	0
70	L:L:E3	R:R:I378	12.0148	4.1	Yes	Yes	1	0	8
71	R:R:I187	R:R:V227	19.4992	3.07	No	No	0	7	6
72	R:R:Y141	R:R:Y145	47.2047	5.96	Yes	Yes	1	7	7
73	L:L:T7	R:R:R190	19.3569	10.35	No	Yes	1	0	6
74	R:R:E288	R:R:Q220	19.412	10.19	Yes	No	0	6	5
75	R:R:R183	R:R:Y145	22.337	3.09	Yes	Yes	1	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Y1	R:R:V227	16.4	1	Yes	No	0	6	0	1
L:L:Y1	R:R:Y231	3.97	1	Yes	Yes	0	8	0	1
L:L:Y1	R:R:W296	4.82	1	Yes	Yes	0	6	0	1
L:L:?2	R:R:E377	3.81	1	Yes	No	0	7	0	1
L:L:?2	R:R:I378	6.83	1	Yes	Yes	0	8	0	1
L:L:E3	R:R:Y145	8.98	1	Yes	Yes	0	7	0	1
L:L:E3	R:R:R183	4.65	1	Yes	Yes	0	8	0	1
L:L:E3	R:R:I187	8.2	1	Yes	No	0	7	0	1
L:L:E3	R:R:I378	4.1	1	Yes	Yes	0	8	0	1
L:L:E3	R:R:S381	8.62	1	Yes	No	0	5	0	1
L:L:F6	R:R:L134	3.65	1	Yes	No	0	5	0	1
L:L:F6	R:R:L137	3.65	1	Yes	No	0	6	0	1
L:L:F6	R:R:Q138	4.68	1	Yes	No	0	5	0	1
L:L:F6	R:R:Y141	14.44	1	Yes	Yes	0	7	0	1
L:L:F6	R:R:L374	3.65	1	Yes	No	0	6	0	1
L:L:T7	R:R:R190	10.35	1	No	Yes	0	6	0	1
L:L:T7	R:R:D191	7.23	1	No	No	0	7	0	1
L:L:T7	R:R:E288	5.64	1	No	Yes	0	6	0	1
L:L:S8	R:R:N290	5.96	0	No	No	0	6	0	1
L:L:D9	R:R:R370	5.96	0	No	Yes	0	5	0	1
L:L:Y10	R:R:L134	7.03	1	Yes	No	0	5	0	1
L:L:Y10	R:R:E135	6.73	1	Yes	No	0	3	0	1
L:L:S11	R:R:E288	5.75	0	No	Yes	0	6	0	1
L:L:S11	R:R:R289	6.59	0	No	No	0	4	0	1
L:L:I12	R:R:R289	8.77	0	No	No	0	4	0	1
L:L:D15	R:R:T31	7.23	0	Yes	No	0	5	0	1
L:L:D15	R:R:A32	3.09	0	Yes	No	0	4	0	1
L:L:D15	R:R:R289	4.76	0	Yes	No	0	4	0	1
L:L:I17	R:R:R131	3.76	0	No	No	0	3	0	1
L:L:Q19	R:R:A32	3.03	0	No	No	0	4	0	1
L:L:Q19	R:R:L35	10.65	0	No	No	0	5	0	1
L:L:K20	R:R:L128	5.64	0	No	No	0	3	0	1
L:L:F22	R:R:L35	3.65	2	Yes	No	0	5	0	1
L:L:F22	R:R:Y36	6.19	2	Yes	Yes	0	3	0	1
L:L:F22	R:R:W39	5.01	2	Yes	Yes	0	6	0	1
L:L:F22	R:R:L201	7.31	2	Yes	No	0	2	0	1
L:L:W25	R:R:L201	4.56	0	No	No	0	2	0	1
L:L:L26	R:R:W39	6.83	2	Yes	Yes	0	6	0	1
L:L:L26	R:R:Y68	11.72	2	Yes	Yes	0	5	0	1
L:L:L26	R:R:Y87	5.86	2	Yes	Yes	0	4	0	1
L:L:I27	R:R:Y68	8.46	2	No	Yes	0	5	0	1
L:L:I27	R:R:R113	6.26	2	No	Yes	0	6	0	1
L:L:I27	R:R:H115	7.95	2	No	No	0	7	0	1
L:L:G30	R:R:M67	5.24	0	No	No	0	3	0	1
L:L:S32	R:R:Y200	5.09	0	No	No	0	4	0	1
R:R:E34	R:R:T31	12.7	0	No	No	5	5	2	1
R:R:Q285	R:R:T31	5.67	0	No	No	3	5	2	1
R:R:L35	R:R:P89	9.85	0	No	Yes	5	3	1	2
R:R:L201	R:R:Y36	8.21	2	No	Yes	2	3	1	1
R:R:Q204	R:R:Y36	3.38	0	No	Yes	4	3	2	1
R:R:R43	R:R:W39	7	0	Yes	Yes	4	6	2	1
R:R:M67	R:R:W39	6.98	0	No	Yes	3	6	1	1
R:R:W39	R:R:Y87	11.58	2	Yes	Yes	6	4	1	1
R:R:P85	R:R:Y42	5.56	2	No	Yes	8	7	2	2
R:R:Y42	R:R:Y87	6.95	2	Yes	Yes	7	4	2	1
R:R:D66	R:R:Y68	14.94	2	No	Yes	9	5	2	1
R:R:D66	R:R:V69	7.3	2	No	No	9	5	2	2
R:R:D66	R:R:W71	7.82	2	No	Yes	9	9	2	2
R:R:V69	R:R:Y68	8.83	2	No	Yes	5	5	2	1
R:R:Y68	R:R:Y87	6.95	2	Yes	Yes	5	4	1	1
R:R:R113	R:R:Y68	12.35	2	Yes	Yes	6	5	1	1
R:R:V69	R:R:W71	8.58	2	No	Yes	5	9	2	2
R:R:R101	R:R:W71	6	2	No	Yes	8	9	2	2
R:R:R113	R:R:W71	5	2	Yes	Yes	6	9	1	2
R:R:P85	R:R:Y87	8.34	2	No	Yes	8	4	2	1
R:R:R101	R:R:R113	10.66	2	No	Yes	8	6	2	1
R:R:H115	R:R:R113	3.39	2	No	Yes	7	6	1	1
R:R:E119	R:R:H115	11.08	0	No	No	1	7	2	1
R:R:Q130	R:R:R370	9.35	0	No	Yes	3	5	2	1
R:R:L132	R:R:R131	3.64	0	No	No	3	3	2	1
R:R:E135	R:R:R131	8.14	0	No	No	3	3	1	1
R:R:I133	R:R:R370	3.76	0	No	Yes	4	5	2	1
R:R:L134	R:R:R370	3.64	1	No	Yes	5	5	1	1
R:R:Q138	R:R:Y141	10.15	1	No	Yes	5	7	1	1
R:R:I378	R:R:M140	4.37	1	Yes	No	8	6	1	2
R:R:Y141	R:R:Y145	5.96	1	Yes	Yes	7	7	1	1
R:R:D191	R:R:Y141	6.9	1	No	Yes	7	7	1	1
R:R:I378	R:R:Y141	3.63	1	Yes	Yes	8	7	1	1
R:R:R183	R:R:Y145	3.09	1	Yes	Yes	8	7	1	1
R:R:A184	R:R:Y145	4	0	No	Yes	8	7	2	1
R:R:S382	R:R:Y145	5.09	0	No	Yes	9	7	2	1
R:R:R183	R:R:V227	9.15	1	Yes	No	8	6	1	1
R:R:N230	R:R:R183	13.26	0	No	Yes	9	8	2	1
R:R:R183	R:R:Y231	6.17	1	Yes	Yes	8	8	1	1
R:R:R183	R:R:S381	3.95	1	Yes	No	8	5	1	1
R:R:I187	R:R:T223	6.08	0	No	No	7	6	1	2
R:R:I187	R:R:V227	3.07	0	No	No	7	6	1	1
R:R:D191	R:R:R190	14.29	1	No	Yes	7	6	1	1
R:R:Q220	R:R:R190	23.36	0	No	Yes	5	6	2	1
R:R:R190	R:R:T223	11.64	1	Yes	No	6	6	1	2
R:R:E288	R:R:P195	9.43	0	Yes	No	6	3	1	2
R:R:E288	R:R:Q220	10.19	0	Yes	No	6	5	1	2
R:R:Q224	R:R:W296	4.38	1	No	Yes	6	6	2	1
R:R:I299	R:R:Q224	8.23	1	Yes	No	7	6	2	2
R:R:I303	R:R:Y231	12.09	0	No	Yes	7	8	2	1
R:R:T306	R:R:Y231	3.75	0	No	Yes	7	8	2	1
R:R:I307	R:R:Y231	3.63	1	No	Yes	7	8	2	1
R:R:E354	R:R:Y231	4.49	1	No	Yes	7	8	2	1
R:R:C286	R:R:E288	6.08	0	No	Yes	9	6	2	1
R:R:N290	R:R:W296	9.04	0	No	Yes	6	6	1	1
R:R:I299	R:R:W296	3.52	1	Yes	Yes	7	6	2	1
R:R:R300	R:R:W296	15.99	0	No	Yes	7	6	2	1
R:R:I303	R:R:R300	5.01	0	No	No	7	7	2	2
R:R:E354	R:R:I307	4.1	1	No	No	7	7	2	2
R:R:E377	R:R:F357	15.16	0	No	No	7	7	1	2
R:R:L369	R:R:R370	6.07	0	No	Yes	4	5	2	1
R:R:G33	R:R:Y36	2.9	0	No	Yes	5	3	2	1
L:L:A18	R:R:A32	1.79	0	No	No	0	4	0	1
R:R:G375	R:R:L137	1.71	0	No	No	5	6	2	1
R:R:G375	R:R:L374	1.71	0	No	No	5	6	2	1
L:L:L14	R:R:P197	1.64	0	No	No	0	4	0	1
R:R:P197	R:R:R196	1.44	0	No	No	4	3	1	2
R:R:R190	R:R:S189	1.32	1	Yes	No	6	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F383	R:R:G144	7.53	0	Yes	No	6	8	1	2
R:R:P348	R:R:V347	5.3	1	Yes	No	9	8	1	1
R:R:V347	R:R:V352	3.21	1	No	No	8	6	1	2
R:R:V347	W:W:?1	17.7	1	No	Yes	8	0	1	0
R:R:L387	R:R:P348	8.21	1	No	Yes	6	9	1	1
R:R:P348	R:R:V388	3.53	1	Yes	No	9	9	1	2
R:R:P348	W:W:?1	9.76	1	Yes	Yes	9	0	1	0
R:R:G351	R:R:H353	3.18	1	No	Yes	9	8	2	1
R:R:G351	R:R:Q384	3.29	1	No	No	9	9	2	1
R:R:E354	R:R:H353	3.69	1	No	Yes	7	8	2	1
R:R:H353	R:R:L380	9	1	Yes	No	8	7	1	1
R:R:H353	R:R:Q384	14.84	1	Yes	No	8	9	1	1
R:R:H353	W:W:?1	17.19	1	Yes	Yes	8	0	1	0
R:R:F357	R:R:V356	9.18	0	No	No	7	6	2	1
R:R:V356	W:W:?1	5.53	0	No	Yes	6	0	1	0
R:R:F379	R:R:F383	12.86	0	No	Yes	6	6	2	1
R:R:L380	W:W:?1	15.42	1	No	Yes	7	0	1	0
R:R:F383	R:R:S382	6.61	0	Yes	No	6	9	1	2
R:R:F383	W:W:?1	3.62	0	Yes	Yes	6	0	1	0
R:R:Q384	W:W:?1	6.92	1	No	Yes	9	0	1	0
R:R:L387	R:R:L391	6.92	1	No	No	6	7	1	2
R:R:L387	W:W:?1	14.39	1	No	Yes	6	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7RBT_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.03
Number of Linked Nodes	373
Number of Links	442
Number of Hubs	60
Number of Links mediated by Hubs	229
Number of Communities	10
Number of Nodes involved in Communities	100
Number of Links involved in Communities	145

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	223685
Length Of Smallest Path	3
Average Path Length	19.3113
Length of Longest Path	38
Minimum Path Strength	1.09
Average Path Strength	6.88701
Maximum Path Strength	21.99
Minimum Path Correlation	0.7
Average Path Correlation	0.969644
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	69.8404
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.0783
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • amide binding • glucagon family peptide binding • peptide hormone binding • hormone binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • gastric inhibitory peptide receptor activity • peptide receptor activity • G protein-coupled peptide receptor activity • response to stress • response to wounding • response to axon injury • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • response to metal ion • response to calcium ion • negative adaptation of signaling pathway • negative regulation of signaling • negative regulation of biological process • desensitization of G protein-coupled receptor signaling pathway • regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • regulation of response to stimulus • adaptation of signaling pathway • regulation of cell communication • metabolic process • generation of precursor metabolites and energy • response to hexose • response to monosaccharide • response to carbohydrate • response to glucose • gastric inhibitory peptide signaling pathway • pancreas development • endocrine system development • endocrine pancreas development • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • cell surface receptor signaling pathway • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to fatty acid • response to nutrient levels • response to nutrient • positive regulation of cell communication • positive regulation of establishment of protein localization • positive regulation of insulin secretion • positive regulation of peptide hormone secretion • positive regulation of protein localization • positive regulation of biological process • positive regulation of secretion by cell • positive regulation of protein transport • positive regulation of hormone secretion • positive regulation of secretion • positive regulation of cellular process • positive regulation of peptide secretion • positive regulation of protein secretion • positive regulation of transport • positive regulation of signaling
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • FnI-like domain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • FnI-like domain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	AIB
PDB Residues	L:L:?2 L:L:?13
Environment Details	Open EMBL-EBI Page
Code	AIB
Name	2-aminoisobutyric acid
Synonyms	α,α-dimethylglycine
Identifier
Formula	C4 H9 N O2
Molecular Weight	103.12
SMILES
PubChem	5245672
Formal Charge	0
Total Atoms	16
Total Chiral Atoms	0
Total Bonds	15
Total Aromatic Bonds	0


Code	41Y
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	41Y
Name	2-fluoro-4-[(1R)-6-methoxy-1-methyl-2-{(1S)-1-[4-(propan-2-yl)phenyl]ethyl}-1,2,3,4-tetrahydroisoquinolin-5-yl]-6-[(2-methylpropyl)amino]phenol
Synonyms
Identifier
Formula	C32 H41 F N2 O2
Molecular Weight	504.679
SMILES
PubChem	163183774
Formal Charge	0
Total Atoms	78
Total Chiral Atoms	2
Total Bonds	81
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P48546
Sequence	>7RBT_nogp_Chain_R G Q T A G E L Y Q R W E R Y R R E C Q E T L A A A E P P S G L A C N G S F D M Y V C W D Y A A P N A T A R A S C P W Y L P W H H H V A A G F V L R Q C G S D G Q W G L W R D H T Q C E N P E K N E A F L D Q R L I L E R L Q V M Y T V G Y S L S L A T L L L A L L I L S L F R R L H C T R N Y I H I N L F T S F M L R A A A I L S R D R L L P R P G P Y L G D Q A L A L W N Q A L A A C R T A Q I V T Q Y C V G A N Y T W L L V E G V Y L H S L L V L V G G S E E G H F R Y Y L L L G W G A P A L F V I P W V I V R Y L Y E N T Q C W E R N E V K A I W W I I R T P I L M T I L I N F L I F I R I L G I L L S K L R T R D Y R L R L A R S T L T L V P L L G V H E V V F A P V T E E Q A R G A L R F A K L G F E I F L S S F Q G F L V S V L Y C F I N K E V Q S E I R R G W H H C R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YW4	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ22	3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW4 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-		3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8WA3	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	2.86	2024-03-06	10.1038/s41421-024-00649-0
	8WA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		2.86	2024-03-06	10.1038/s41421-024-00649-0
	8ITM	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.13	2023-10-18	10.1073/pnas.2306145120
	8ITM (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.13	2023-10-18	10.1073/pnas.2306145120
	8ITL	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.23	2023-10-18	10.1073/pnas.2306145120
	8ITL (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.23	2023-10-18	10.1073/pnas.2306145120
	7RBT	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	PubChem 163183774	chim(NtGi1-Gs)/β1/γ2	3.08	2022-04-13	10.1073/pnas.2116506119
	7RBT (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	PubChem 163183774		3.08	2022-04-13	10.1073/pnas.2116506119
	7RA3	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	chim(NtGi1-Gs)/β1/γ2	3.24	2022-04-13	10.1073/pnas.2116506119
	7RA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		3.24	2022-04-13	10.1073/pnas.2116506119
	7VAB	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-03-02	10.1038/s41467-022-28683-0
	7VAB (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-		3.2	2022-03-02	10.1038/s41467-022-28683-0
	7FIY	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	10.1038/s41467-022-28683-0
	7FIY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	10.1038/s41467-022-28683-0
	7FIN	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-	Gs/β1/γ2	3.1	2022-02-23	10.1038/s41467-022-28683-0
	7FIN (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-		3.1	2022-02-23	10.1038/s41467-022-28683-0
	7DTY	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	Gs/β1/γ2	2.98	2021-08-04	10.7554/eLife.68719
	7DTY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		2.98	2021-08-04	10.7554/eLife.68719

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