psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q30	R:R:R289	5.84	No	No	0	5	4
2	R:R:E34	R:R:T31	7.06	No	Yes	0	5	5
3	R:R:Q285	R:R:T31	8.5	No	Yes	0	3	5
4	L:L:D15	R:R:T31	2.89	No	Yes	0	0	5
5	R:R:L35	R:R:P89	3.28	No	No	0	5	3
6	L:L:F22	R:R:L35	7.31	Yes	No	0	0	5
7	L:L:F22	R:R:Y36	8.25	Yes	No	0	0	3
8	R:R:R38	R:R:W86	5	No	Yes	0	5	1
9	R:R:R43	R:R:W39	5	No	Yes	2	4	6
10	R:R:F65	R:R:W39	3.01	Yes	Yes	2	7	6
11	R:R:W39	R:R:Y87	8.68	Yes	Yes	2	6	4
12	L:L:F22	R:R:W39	14.03	Yes	Yes	2	0	6
13	L:L:L26	R:R:W39	7.97	Yes	Yes	2	0	6
14	R:R:E40	R:R:Q204	12.74	No	No	0	3	4
15	R:R:R41	R:R:W86	6	No	Yes	0	5	1
16	R:R:V69	R:R:Y42	3.79	Yes	Yes	2	5	7
17	R:R:C70	R:R:Y42	4.03	No	Yes	0	9	7
18	R:R:P85	R:R:Y42	5.56	Yes	Yes	2	8	7
19	R:R:W86	R:R:Y42	8.68	Yes	Yes	0	1	7
20	R:R:Y42	R:R:Y87	8.94	Yes	Yes	2	7	4
21	R:R:F65	R:R:R43	11.76	Yes	No	2	7	4
22	R:R:E48	R:R:R44	3.49	No	No	0	3	5
23	R:R:E45	R:R:W86	5.45	No	Yes	0	4	1
24	R:R:C46	R:R:L50	3.17	No	No	0	8	4
25	R:R:C46	R:R:F65	5.59	No	Yes	0	8	7
26	R:R:C46	R:R:C70	7.28	No	No	0	8	9
27	R:R:A53	R:R:Y73	4	No	Yes	0	1	4
28	R:R:C103	R:R:C61	7.28	No	No	0	9	9
29	R:R:C61	R:R:W109	13.06	No	Yes	0	9	9
30	R:R:N62	R:R:Y73	4.65	No	Yes	0	4	4
31	R:R:G63	R:R:W109	4.22	No	Yes	0	4	9
32	R:R:D66	R:R:W71	7.82	No	Yes	2	9	9
33	R:R:D66	R:R:R101	3.57	No	No	2	9	8
34	R:R:D66	R:R:R113	7.15	No	No	2	9	6
35	L:L:L27	R:R:Y68	10.55	Yes	No	0	0	5
36	R:R:V69	R:R:W71	7.36	Yes	Yes	2	5	9
37	R:R:A82	R:R:V69	3.39	No	Yes	2	5	5
38	R:R:P85	R:R:V69	7.07	Yes	Yes	2	8	5
39	R:R:A82	R:R:W71	5.19	No	Yes	2	5	9
40	R:R:V99	R:R:W71	3.68	No	Yes	0	7	9
41	R:R:R101	R:R:W71	14.99	No	Yes	2	8	9
42	R:R:W109	R:R:W71	2.81	Yes	Yes	2	9	9
43	R:R:R113	R:R:W71	3	No	Yes	2	6	9
44	R:R:A74	R:R:C103	3.61	No	No	0	7	9
45	R:R:A74	R:R:W109	3.89	No	Yes	0	7	9
46	R:R:L100	R:R:T79	2.95	No	No	0	4	5
47	R:R:F98	R:R:R81	4.28	No	No	0	3	4
48	R:R:L100	R:R:R81	3.64	No	No	0	4	4
49	R:R:C84	R:R:H91	2.95	Yes	No	0	9	5
50	R:R:C84	R:R:V94	5.12	Yes	No	0	9	3
51	R:R:C118	R:R:C84	7.28	No	Yes	0	9	9
52	R:R:P85	R:R:Y87	8.34	Yes	Yes	2	8	4
53	R:R:L88	R:R:P85	4.93	No	Yes	0	5	8
54	L:L:L26	R:R:Y87	3.52	Yes	Yes	2	0	4
55	R:R:L88	R:R:W90	5.69	No	Yes	0	5	4
56	R:R:P89	R:R:W90	9.46	No	Yes	0	3	4
57	R:R:V94	R:R:W90	6.13	No	Yes	0	3	4
58	L:L:Q20	R:R:W90	6.57	No	Yes	0	0	4
59	L:L:V23	R:R:W90	3.68	No	Yes	0	0	4
60	R:R:A95	R:R:H91	2.93	No	No	0	5	5
61	R:R:G97	R:R:Q117	4.93	No	No	0	6	4
62	R:R:F98	R:R:Q117	3.51	No	No	0	3	4
63	R:R:D114	R:R:L100	9.5	No	No	0	8	4
64	R:R:R101	R:R:W109	20.99	No	Yes	2	8	9
65	R:R:D106	R:R:Q108	14.36	No	No	0	5	5
66	R:R:L111	R:R:W112	3.42	No	No	0	5	5
67	L:L:L27	R:R:R113	3.64	Yes	No	0	0	6
68	L:L:L27	R:R:H115	12.86	Yes	No	0	0	7
69	R:R:N120	R:R:P121	6.52	No	No	0	3	2
70	R:R:E122	R:R:N120	2.63	No	No	0	2	3
71	L:L:Q20	R:R:N120	7.92	No	No	0	0	3
72	R:R:E122	R:R:F127	7	No	Yes	0	2	2
73	R:R:F127	R:R:N124	3.62	Yes	No	0	2	1
74	R:R:F127	R:R:Q130	4.68	Yes	No	0	2	3
75	L:L:Y13	R:R:F127	8.25	Yes	Yes	0	0	2
76	L:L:R17	R:R:L128	3.64	No	No	0	0	3
77	R:R:F371	R:R:Q130	10.54	No	No	0	4	3
78	L:L:Y13	R:R:R131	8.23	Yes	No	5	0	3
79	L:L:R17	R:R:R131	11.73	No	No	5	0	3
80	R:R:L132	R:R:R136	17.01	No	No	0	3	4
81	R:R:I133	R:R:L137	2.85	No	No	0	4	6
82	L:L:F6	R:R:L134	3.65	No	No	0	0	5
83	L:L:K10	R:R:L134	2.82	Yes	No	0	0	5
84	L:L:Y13	R:R:L134	4.69	Yes	No	0	0	5
85	L:L:?31	R:R:E135	16.62	No	No	0	0	3
86	R:R:G375	R:R:L137	5.13	No	No	0	5	6
87	R:R:Q138	R:R:Y141	7.89	Yes	Yes	1	5	7
88	R:R:D191	R:R:Q138	7.83	No	Yes	0	7	5
89	L:L:K10	R:R:Q138	9.49	Yes	Yes	1	0	5
90	L:L:?31	R:R:Q138	14.31	No	Yes	1	0	5
91	R:R:F379	R:R:M140	6.22	No	No	0	6	6
92	R:R:Y141	R:R:Y145	5.96	Yes	Yes	1	7	7
93	R:R:I378	R:R:Y141	3.63	No	Yes	1	8	7
94	L:L:Q3	R:R:Y141	4.51	Yes	Yes	1	0	7
95	L:L:F6	R:R:Y141	6.19	No	Yes	1	0	7
96	R:R:F383	R:R:G144	4.52	No	No	0	6	8
97	R:R:I187	R:R:Y145	7.25	No	Yes	1	7	7
98	R:R:S382	R:R:Y145	10.17	No	Yes	0	9	7
99	L:L:Q3	R:R:Y145	10.15	Yes	Yes	1	0	7
100	R:R:L147	R:R:T151	2.95	No	No	6	5	7
101	R:R:F386	R:R:L147	6.09	Yes	No	6	5	5
102	R:R:F386	R:R:S148	3.96	Yes	No	0	5	9
103	R:R:F386	R:R:T151	7.78	Yes	No	6	5	7
104	R:R:S389	R:R:T151	4.8	No	No	0	8	7
105	R:R:F177	R:R:L152	4.87	Yes	No	0	9	9
106	R:R:L152	R:R:S389	4.5	No	No	0	9	8
107	R:R:L153	R:R:M181	5.65	No	No	0	3	7
108	R:R:I158	R:R:L154	4.28	Yes	No	0	8	5
109	R:R:A155	R:R:F177	2.77	No	Yes	0	9	9
110	R:R:I174	R:R:L156	4.28	No	No	0	7	6
111	R:R:L156	R:R:T178	2.95	No	No	0	6	3
112	R:R:L156	R:R:M181	4.24	No	No	0	6	7
113	R:R:C393	R:R:I158	3.27	No	Yes	0	9	8
114	R:R:I158	R:R:I403	2.94	Yes	No	4	8	5
115	R:R:I174	R:R:L159	5.71	No	No	0	7	8
116	R:R:E402	R:R:F162	17.49	No	No	4	8	7
117	R:R:H166	R:R:R163	5.64	No	No	0	7	8
118	R:R:E402	R:R:R164	9.3	No	No	4	8	7
119	R:R:R164	R:R:R405	9.6	No	No	4	7	8
120	R:R:E398	R:R:L165	5.3	No	No	0	9	9
121	R:R:H166	R:R:Y171	11.98	No	No	0	7	6
122	R:R:C167	R:R:N170	6.3	No	No	0	8	9
123	R:R:T168	R:R:Y240	4.99	No	Yes	0	8	8
124	R:R:N170	R:R:R169	8.44	No	No	0	9	9
125	R:R:H173	R:R:R169	4.51	No	No	0	9	9
126	R:R:E237	R:R:I172	6.83	Yes	No	0	9	9
127	R:R:I172	R:R:Y240	3.63	No	Yes	0	9	8
128	R:R:E237	R:R:H173	11.08	Yes	No	0	9	9
129	R:R:H173	R:R:Y392	9.8	No	Yes	0	9	8
130	R:R:N175	R:R:W233	14.69	No	Yes	0	9	9
131	R:R:F180	R:R:L176	6.09	No	No	0	8	9
132	R:R:L176	R:R:L234	4.15	No	No	0	9	9
133	R:R:E237	R:R:L176	5.3	Yes	No	0	9	9
134	R:R:F180	R:R:N230	16.92	No	No	0	8	9
135	R:R:F180	R:R:G385	3.01	No	No	0	8	9
136	R:R:I187	R:R:R183	5.01	No	Yes	1	7	8
137	R:R:R183	R:R:V227	6.54	Yes	No	1	8	6
138	R:R:N230	R:R:R183	9.64	No	Yes	0	9	8
139	L:L:H1	R:R:R183	5.64	Yes	Yes	1	0	8
140	R:R:A186	R:R:T223	3.36	No	No	0	6	6
141	R:R:A186	R:R:C226	3.61	No	No	0	6	6
142	L:L:Q3	R:R:I187	9.61	Yes	No	1	0	7
143	R:R:A219	R:R:R190	2.77	No	Yes	0	6	6
144	R:R:Q220	R:R:R190	8.18	No	Yes	0	5	6
145	R:R:R190	R:R:T223	7.76	Yes	No	0	6	6
146	L:L:T7	R:R:R190	11.64	No	Yes	0	0	6
147	R:R:A215	R:R:L193	4.73	No	No	0	3	5
148	R:R:L194	R:R:P195	4.93	No	No	0	7	3
149	R:R:E288	R:R:L194	10.6	Yes	No	0	6	7
150	L:L:L14	R:R:P197	9.85	No	No	0	0	4
151	R:R:G198	R:R:P199	4.06	No	Yes	0	3	3
152	L:L:A18	R:R:P199	3.74	No	Yes	0	0	3
153	R:R:L213	R:R:W209	3.42	No	No	0	4	4
154	R:R:L213	R:R:Q285	2.66	No	No	0	4	3
155	R:R:C216	R:R:C286	7.28	No	No	0	9	9
156	R:R:N283	R:R:R217	10.85	No	No	3	6	8
157	R:R:R217	R:R:W287	6	No	Yes	3	8	9
158	R:R:Q220	R:R:Q224	5.12	No	No	0	5	6
159	R:R:I221	R:R:V275	6.14	No	No	3	5	6
160	R:R:I221	R:R:W287	5.87	No	Yes	3	5	9
161	R:R:Q224	R:R:W274	6.57	No	Yes	3	6	8
162	R:R:I299	R:R:Q224	2.74	No	No	3	7	6
163	R:R:W264	R:R:Y225	4.82	Yes	No	0	9	8
164	R:R:P267	R:R:Y225	6.95	Yes	No	0	9	8
165	L:L:H1	R:R:V227	13.84	Yes	No	1	0	6
166	R:R:G228	R:R:P267	4.06	No	Yes	0	5	9
167	R:R:F270	R:R:G228	4.52	No	No	0	5	5
168	R:R:L234	R:R:N230	4.12	No	No	0	9	9
169	R:R:I303	R:R:Y231	12.09	No	Yes	0	7	8
170	R:R:I307	R:R:Y231	4.84	No	Yes	1	7	8
171	R:R:E354	R:R:Y231	5.61	Yes	Yes	1	7	8
172	R:R:G263	R:R:T232	3.64	No	No	0	9	6
173	R:R:A266	R:R:T232	5.03	No	No	0	4	6
174	R:R:P267	R:R:T232	6.99	Yes	No	0	9	6
175	R:R:V236	R:R:W233	6.13	No	Yes	0	8	9
176	R:R:L260	R:R:W233	3.42	No	Yes	7	6	9
177	R:R:G263	R:R:W233	7.04	No	Yes	0	9	9
178	R:R:W233	R:R:W264	15.93	Yes	Yes	7	9	9
179	R:R:L235	R:R:V239	2.98	Yes	No	0	8	7
180	R:R:L235	R:R:T306	7.37	Yes	No	0	8	7
181	R:R:I309	R:R:L235	2.85	No	Yes	0	6	8
182	R:R:L235	R:R:N310	9.61	Yes	No	0	8	9
183	R:R:V236	R:R:Y259	3.79	No	No	0	8	8
184	R:R:L262	R:R:V236	4.47	No	No	0	6	8
185	R:R:E237	R:R:L349	9.28	Yes	Yes	0	9	9
186	R:R:L244	R:R:Y240	12.89	No	Yes	0	8	8
187	R:R:Y240	R:R:Y259	5.96	Yes	No	0	8	8
188	R:R:L241	R:R:L245	4.15	No	No	8	9	8
189	R:R:I317	R:R:L241	4.28	No	No	8	9	9
190	R:R:H242	R:R:V246	12.45	No	No	9	8	7
191	R:R:H242	R:R:I313	3.98	No	No	0	8	8
192	R:R:H242	R:R:R316	7.9	No	No	9	8	8
193	R:R:L247	R:R:S243	4.5	No	No	0	5	7
194	R:R:E252	R:R:S243	2.87	No	No	0	7	7
195	R:R:E252	R:R:L244	5.3	No	No	0	7	8
196	R:R:I317	R:R:L245	5.71	No	No	8	9	8
197	R:R:R316	R:R:V246	11.77	No	No	9	8	7
198	R:R:E252	R:R:H255	3.69	No	No	0	7	4
199	R:R:H255	R:R:Y258	4.36	No	No	0	4	3
200	R:R:H255	R:R:Y259	8.71	No	No	0	4	8
201	R:R:R257	R:R:Y258	6.17	No	No	0	3	3
202	R:R:L260	R:R:W264	3.42	No	Yes	7	6	9
203	R:R:F270	R:R:P302	14.45	No	No	0	5	9
204	R:R:I272	R:R:P273	3.39	No	No	0	2	4
205	R:R:R278	R:R:W274	9	Yes	Yes	3	8	8
206	R:R:W274	R:R:W287	3.75	Yes	Yes	3	8	9
207	R:R:I298	R:R:W274	3.52	No	Yes	0	8	8
208	R:R:I299	R:R:W274	12.92	No	Yes	3	7	8
209	R:R:V275	R:R:W287	4.9	No	Yes	3	6	9
210	R:R:I276	R:R:L280	2.85	No	No	0	3	3
211	R:R:V277	R:R:Y281	7.57	No	No	0	5	3
212	R:R:I295	R:R:V277	7.68	No	No	0	3	5
213	R:R:E282	R:R:R278	3.49	Yes	Yes	3	5	8
214	R:R:R278	R:R:T284	5.17	Yes	No	3	8	4
215	R:R:R278	R:R:W287	25.99	Yes	Yes	3	8	9
216	R:R:I295	R:R:R278	5.01	No	Yes	0	3	8
217	R:R:L280	R:R:Y279	3.52	No	No	0	3	3
218	R:R:E282	R:R:T284	2.82	Yes	No	3	5	4
219	R:R:E282	R:R:E291	6.34	Yes	No	0	5	4
220	R:R:E282	R:R:V292	5.7	Yes	No	0	5	6
221	R:R:N283	R:R:W287	4.52	No	Yes	3	6	9
222	R:R:C286	R:R:E288	4.56	No	Yes	0	9	6
223	L:L:T7	R:R:E288	4.23	No	Yes	0	0	6
224	L:L:S11	R:R:E288	8.62	No	Yes	0	0	6
225	L:L:S11	R:R:R289	6.59	No	No	0	0	4
226	L:L:D15	R:R:R289	8.34	No	No	0	0	4
227	R:R:N290	R:R:W296	24.86	No	Yes	0	6	6
228	L:L:S8	R:R:N290	5.96	No	No	0	0	6
229	R:R:I295	R:R:V292	7.68	No	No	0	3	6
230	R:R:E362	R:R:K293	9.45	No	No	0	5	5
231	R:R:I299	R:R:W296	7.05	No	Yes	0	7	6
232	R:R:R300	R:R:W296	12	No	Yes	0	7	6
233	L:L:G4	R:R:W296	2.81	No	Yes	0	0	6
234	L:L:T5	R:R:W296	3.64	No	Yes	0	0	6
235	R:R:R300	R:R:W297	18.99	No	No	0	7	7
236	R:R:E362	R:R:R300	3.49	No	No	0	5	7
237	R:R:P302	R:R:T301	3.5	No	No	0	9	4
238	R:R:E354	R:R:I307	5.47	Yes	No	1	7	7
239	R:R:L350	R:R:N310	2.75	Yes	No	0	9	9
240	R:R:F311	R:R:I315	6.28	No	No	0	6	5
241	R:R:F311	R:R:V355	7.87	No	No	0	6	5
242	R:R:I313	R:R:I317	2.94	No	No	0	8	9
243	R:R:F314	R:R:L318	8.53	Yes	No	0	9	7
244	R:R:F314	R:R:L346	6.09	Yes	No	0	9	9
245	R:R:F314	R:R:V347	3.93	Yes	Yes	10	9	8
246	R:R:F314	R:R:L350	3.65	Yes	Yes	0	9	9
247	R:R:F314	R:R:V352	15.73	Yes	No	10	9	6
248	R:R:I320	R:R:K324	2.91	No	No	0	8	9
249	R:R:L321	R:R:S342	3	No	No	0	9	9
250	R:R:L322	R:R:L339	4.15	No	No	0	5	9
251	R:R:M330	R:R:R328	7.44	No	No	0	5	6
252	R:R:D334	R:R:R331	9.53	No	No	0	6	5
253	R:R:R336	R:R:Y335	14.4	No	No	0	6	5
254	R:R:R338	R:R:R341	12.79	No	No	0	9	9
255	R:R:L339	R:R:T343	2.95	No	No	0	9	9
256	R:R:F345	R:R:L391	4.87	No	No	0	8	7
257	R:R:F345	R:R:Y392	5.16	No	Yes	0	8	8
258	R:R:L346	R:R:L349	2.77	No	Yes	0	9	9
259	R:R:P348	R:R:V347	3.53	No	Yes	0	9	8
260	R:R:V347	R:R:V352	8.02	Yes	No	10	8	6
261	R:R:L349	R:R:L350	4.15	Yes	Yes	0	9	9
262	R:R:L349	R:R:Y392	10.55	Yes	Yes	0	9	8
263	R:R:G351	R:R:H353	3.18	No	Yes	0	9	8
264	R:R:E354	R:R:H353	11.08	Yes	Yes	0	7	8
265	R:R:H353	R:R:L380	5.14	Yes	No	0	8	7
266	R:R:H353	R:R:Q384	8.65	Yes	No	0	8	9
267	R:R:E354	R:R:S381	4.31	Yes	No	0	7	5
268	R:R:F357	R:R:K373	4.96	No	Yes	1	7	7
269	R:R:E377	R:R:F357	32.65	No	No	1	7	7
270	R:R:K373	R:R:V360	7.59	Yes	No	0	7	4
271	R:R:Q364	R:R:T361	2.83	No	No	0	5	7
272	R:R:A365	R:R:R370	6.91	No	Yes	0	6	5
273	R:R:F371	R:R:R370	6.41	No	Yes	0	4	5
274	R:R:K373	R:R:R370	3.71	Yes	Yes	0	7	5
275	R:R:L374	R:R:R370	7.29	No	Yes	0	6	5
276	L:L:D9	R:R:R370	5.96	No	Yes	0	0	5
277	R:R:E377	R:R:K373	2.7	No	Yes	1	7	7
278	L:L:?2	R:R:E377	7.61	Yes	No	1	0	7
279	L:L:F6	R:R:I378	8.79	No	No	1	0	8
280	R:R:F379	R:R:F383	9.65	No	No	0	6	6
281	R:R:F383	R:R:S382	2.64	No	No	0	6	9
282	R:R:F386	R:R:V390	7.87	Yes	No	0	5	5
283	R:R:F394	R:R:V390	5.24	No	No	0	8	5
284	R:R:I395	R:R:L391	4.28	No	No	0	5	7
285	R:R:N396	R:R:V399	5.91	No	No	0	9	9
286	R:R:I403	R:R:V399	3.07	No	No	0	5	9
287	R:R:E402	R:R:R405	11.63	No	No	4	8	8
288	R:R:H409	R:R:R405	5.64	No	No	0	7	8
289	R:R:R411	R:R:W407	13.99	No	No	0	4	5
290	L:L:?2	L:L:H1	4.92	Yes	Yes	1	0	0
291	L:L:H1	L:L:Q3	3.71	Yes	Yes	1	0	0
292	L:L:G4	L:L:H1	3.18	No	Yes	1	0	0
293	L:L:?2	L:L:G4	3.28	Yes	No	1	0	0
294	L:L:?2	L:L:T5	7.06	Yes	No	0	0	0
295	L:L:D9	L:L:T5	2.89	No	No	0	0	0
296	L:L:K10	L:L:L14	4.23	Yes	No	0	0	0
297	L:L:?31	L:L:K10	11.37	No	Yes	1	0	0
298	L:L:E16	L:L:K12	4.05	No	No	0	0	0
299	L:L:R17	L:L:Y13	7.2	No	Yes	5	0	0
300	L:L:F22	L:L:L26	8.53	Yes	Yes	2	0	0
301	L:L:L27	L:L:V23	2.98	Yes	No	0	0	0
302	L:L:L26	L:L:W25	3.42	Yes	No	0	0	0
303	R:R:F177	R:R:V388	2.62	Yes	No	0	9	9
304	R:R:F270	R:R:V271	2.62	No	No	0	5	6
305	R:R:F311	R:R:V352	2.62	No	No	0	6	6
306	R:R:D203	R:R:Q204	2.61	No	No	0	3	4
307	R:R:F256	R:R:T168	2.59	No	No	0	5	8
308	R:R:A212	R:R:W209	2.59	No	No	0	6	4
309	R:R:A229	R:R:W264	2.59	No	Yes	0	8	9
310	R:R:V227	R:R:Y231	2.52	No	Yes	1	6	8
311	R:R:V388	R:R:Y392	2.52	No	Yes	0	9	8
312	R:R:F162	R:R:I158	2.51	No	Yes	4	7	8
313	R:R:F162	R:R:I403	2.51	No	No	4	7	5
314	R:R:F65	R:R:M67	2.49	Yes	No	0	7	3
315	R:R:S179	R:R:W233	2.47	No	Yes	0	9	9
316	R:R:F177	R:R:L159	2.44	Yes	No	0	9	8
317	R:R:L325	R:R:R338	2.43	No	No	0	7	9
318	R:R:L280	R:R:Y281	2.34	No	No	0	3	3
319	L:L:E16	R:R:F127	2.33	No	Yes	0	0	2
320	R:R:D72	R:R:Y73	2.3	No	Yes	0	6	4
321	R:R:L182	R:R:W264	2.28	No	Yes	0	7	9
322	R:R:F345	R:R:R341	2.14	No	No	0	8	9
323	R:R:G249	R:R:G250	2.11	No	No	0	7	6
324	L:L:G29	L:L:G30	2.11	No	No	0	0	0
325	R:R:G265	R:R:P267	2.03	No	Yes	0	6	9
326	R:R:C61	R:R:G107	1.96	No	No	0	9	9
327	R:R:C84	R:R:G97	1.96	Yes	No	0	9	6
328	R:R:A207	R:R:G33	1.95	No	No	0	2	5
329	R:R:P197	R:R:P199	1.95	No	Yes	0	4	3
330	R:R:A75	R:R:P76	1.87	No	No	0	2	4
331	L:L:A19	R:R:P89	1.87	No	No	0	0	3
332	R:R:A358	R:R:P359	1.87	No	No	0	6	5
333	R:R:G63	R:R:S64	1.86	No	No	0	4	6
334	R:R:G249	R:R:V248	1.84	No	No	0	7	7
335	R:R:G33	R:R:T31	1.82	No	Yes	0	5	5
336	R:R:A155	R:R:C393	1.81	No	No	0	9	9
337	L:L:A18	R:R:A32	1.79	No	No	0	0	4
338	R:R:A74	R:R:A80	1.79	No	No	0	7	6
339	R:R:G238	R:R:I313	1.76	No	No	0	9	8
340	L:L:G29	R:R:M67	1.75	No	No	0	0	3
341	R:R:G198	R:R:L201	1.71	No	No	0	3	2
342	R:R:G202	R:R:L201	1.71	No	No	0	1	2
343	R:R:C226	R:R:V222	1.71	No	No	0	6	5
344	R:R:G238	R:R:L350	1.71	No	Yes	0	9	9
345	R:R:A294	R:R:V292	1.7	No	No	0	3	6
346	R:R:D106	R:R:G104	1.68	No	No	0	5	4
347	R:R:D106	R:R:G107	1.68	No	No	0	5	9
348	L:L:D28	L:L:G29	1.68	No	No	0	0	0
349	R:R:E253	R:R:G254	1.64	No	No	0	5	5
350	R:R:A268	R:R:I272	1.62	No	No	0	3	2
351	L:L:D21	R:R:P199	1.61	No	Yes	0	0	3
352	R:R:T343	R:R:V347	1.59	No	Yes	0	9	8
353	R:R:G406	R:R:H409	1.59	No	No	0	5	7
354	R:R:A184	R:R:L149	1.58	No	No	0	8	6
355	R:R:A219	R:R:L193	1.58	No	No	0	6	5
356	R:R:A358	R:R:L304	1.58	No	No	0	6	4
357	R:R:I320	R:R:V246	1.54	No	No	0	8	7
358	R:R:N77	R:R:S105	1.49	No	No	0	7	1
359	R:R:L165	R:R:V399	1.49	No	No	0	9	9
360	R:R:I272	R:R:I276	1.47	No	No	0	2	3
361	R:R:I309	R:R:M305	1.46	No	No	0	6	4
362	R:R:G63	R:R:Y73	1.45	No	Yes	0	4	4
363	R:R:D191	R:R:T142	1.45	No	No	0	7	7
364	R:R:P197	R:R:R196	1.44	No	No	0	4	3
365	R:R:E135	R:R:V139	1.43	No	No	0	3	3
366	R:R:I307	R:R:L304	1.43	No	No	0	7	4
367	R:R:I315	R:R:L312	1.43	No	No	0	5	4
368	R:R:Q364	R:R:V360	1.43	No	No	0	5	4
369	R:R:E45	R:R:T49	1.41	No	No	0	4	3
370	R:R:G110	R:R:W109	1.41	No	Yes	0	3	9
371	R:R:E119	R:R:T116	1.41	No	No	0	1	6
372	R:R:L137	R:R:M140	1.41	No	No	0	6	6
373	R:R:L149	R:R:M181	1.41	No	No	0	6	7
374	R:R:E363	R:R:T361	1.41	No	No	0	5	7
375	R:R:L149	R:R:L188	1.38	No	No	0	6	7
376	R:R:E125	R:R:K123	1.35	No	No	0	3	3
377	R:R:F98	R:R:S83	1.32	No	No	0	3	3
378	L:L:D21	L:L:Q24	1.31	No	No	0	0	0
379	L:L:D28	L:L:Q24	1.31	No	No	0	0	0
380	R:R:T168	R:R:Y171	1.25	No	No	0	8	6
381	R:R:L325	R:R:Y335	1.17	No	No	0	7	5
382	R:R:E40	R:R:R44	1.16	No	No	0	3	5
383	R:R:R413	R:R:R414	1.07	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:T31	5.0675	4	0	5
2	R:R:W39	7.738	5	2	6
3	R:R:Y42	6.2	5	2	7
4	R:R:F65	5.7125	4	2	7
5	R:R:V69	5.4025	4	2	5
6	R:R:W71	6.40714	7	2	9
7	R:R:Y73	3.1	4	0	4
8	R:R:C84	4.3275	4	0	9
9	R:R:P85	6.475	4	2	8
10	R:R:W86	6.2825	4	0	1
11	R:R:Y87	7.37	4	2	4
12	R:R:W90	6.306	5	0	4
13	R:R:W109	7.73	6	2	9
14	R:R:F127	5.176	5	0	2
15	R:R:Q138	9.88	4	1	5
16	R:R:Y141	5.636	5	1	7
17	R:R:Y145	8.3825	4	1	7
18	R:R:I158	3.25	4	4	8
19	R:R:F177	3.175	4	0	9
20	R:R:R183	6.7075	4	1	8
21	R:R:R190	7.5875	4	0	6
22	R:R:P199	2.84	4	0	3
23	R:R:Y231	6.265	4	1	8
24	R:R:W233	8.28	6	7	9
25	R:R:L235	5.7025	4	0	8
26	R:R:E237	8.1225	4	0	9
27	R:R:Y240	6.8675	4	0	8
28	R:R:W264	5.808	5	7	9
29	R:R:P267	5.0075	4	0	9
30	R:R:W274	7.152	5	3	8
31	R:R:R278	9.732	5	3	8
32	R:R:E282	4.5875	4	3	5
33	R:R:W287	8.505	6	3	9
34	R:R:E288	7.0025	4	0	6
35	R:R:W296	10.072	5	0	6
36	R:R:F314	7.586	5	10	9
37	R:R:V347	4.2675	4	10	8
38	R:R:L349	6.6875	4	0	9
39	R:R:L350	3.065	4	0	9
40	R:R:H353	7.0125	4	0	8
41	R:R:E354	6.6175	4	1	7
42	R:R:R370	6.056	5	0	5
43	R:R:K373	4.74	4	1	7
44	R:R:F386	6.425	4	6	5
45	R:R:Y392	7.0075	4	0	8
46	L:L:H1	6.258	5	1	0
47	L:L:?2	5.7175	4	1	0
48	L:L:Q3	6.995	4	1	0
49	L:L:K10	6.9775	4	1	0
50	L:L:Y13	7.0925	4	5	0
51	L:L:F22	9.53	4	2	0
52	L:L:L26	5.86	4	2	0
53	L:L:L27	7.5075	4	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Q20	R:R:W90	58.3065	6.57	No	Yes	0	0	4
2	L:L:Q20	R:R:N120	58.9475	7.92	No	No	0	0	3
3	R:R:E122	R:R:N120	60.2227	2.63	No	No	0	2	3
4	R:R:E122	R:R:F127	60.8602	7	No	Yes	0	2	2
5	R:R:I299	R:R:W296	16.7891	7.05	No	Yes	0	7	6
6	R:R:L88	R:R:W90	24.778	5.69	No	Yes	0	5	4
7	R:R:L88	R:R:P85	24.105	4.93	No	Yes	0	5	8
8	R:R:P197	R:R:P199	11.6937	1.95	No	Yes	0	4	3
9	L:L:L14	R:R:P197	12.9825	9.85	No	No	0	0	4
10	L:L:K10	L:L:L14	13.695	4.23	Yes	No	0	0	0
11	L:L:K10	R:R:Q138	14.1456	9.49	Yes	Yes	1	0	5
12	R:R:Q138	R:R:Y141	17.9814	7.89	Yes	Yes	1	5	7
13	L:L:Q3	R:R:Y141	54.5354	4.51	Yes	Yes	1	0	7
14	L:L:H1	L:L:Q3	29.1352	3.71	Yes	Yes	1	0	0
15	L:L:G4	L:L:H1	14.5648	3.18	No	Yes	1	0	0
16	L:L:G4	R:R:W296	14.6374	2.81	No	Yes	0	0	6
17	R:R:P85	R:R:V69	15.7724	7.07	Yes	Yes	2	8	5
18	R:R:W109	R:R:W71	24.647	2.81	Yes	Yes	2	9	9
19	R:R:V69	R:R:W71	15.0211	7.36	Yes	Yes	2	5	9
20	R:R:R113	R:R:W71	14.1633	3	No	Yes	2	6	9
21	L:L:L27	R:R:R113	16.2036	3.64	Yes	No	0	0	6
22	L:L:L27	L:L:V23	18.2324	2.98	Yes	No	0	0	0
23	L:L:V23	R:R:W90	18.9403	3.68	No	Yes	0	0	4
24	L:L:Y13	R:R:F127	59.2912	8.25	Yes	Yes	0	0	2
25	L:L:Y13	R:R:L134	61.6219	4.69	Yes	No	0	0	5
26	L:L:F6	R:R:L134	61.5424	3.65	No	No	0	0	5
27	L:L:F6	R:R:Y141	62.0719	6.19	No	Yes	1	0	7
28	R:R:I187	R:R:R183	54.4507	5.01	No	Yes	1	7	8
29	L:L:H1	R:R:R183	43.1202	5.64	Yes	Yes	1	0	8
30	L:L:Q3	R:R:I187	26.3608	9.61	Yes	No	1	0	7
31	R:R:F177	R:R:V388	39.7985	2.62	Yes	No	0	9	9
32	R:R:V388	R:R:Y392	40.9862	2.52	No	Yes	0	9	8
33	R:R:H173	R:R:Y392	25.4139	9.8	No	Yes	0	9	8
34	R:R:E237	R:R:H173	27.6645	11.08	Yes	No	0	9	9
35	R:R:E237	R:R:L176	98.9261	5.3	Yes	No	0	9	9
36	R:R:F180	R:R:L176	49.7453	6.09	No	No	0	8	9
37	R:R:F180	R:R:N230	50.1032	16.92	No	No	0	8	9
38	R:R:N230	R:R:R183	100	9.64	No	Yes	0	9	8
39	R:R:L349	R:R:Y392	26.3533	10.55	Yes	Yes	0	9	8
40	R:R:E237	R:R:L349	50.5332	9.28	Yes	Yes	0	9	9
41	R:R:L176	R:R:L234	49.644	4.15	No	No	0	9	9
42	R:R:L234	R:R:N230	49.823	4.12	No	No	0	9	9
43	R:R:F177	R:R:L159	10.9869	2.44	Yes	No	0	9	8
44	R:R:C393	R:R:I158	15.805	3.27	No	Yes	0	9	8
45	R:R:A155	R:R:C393	17.0156	1.81	No	No	0	9	9
46	R:R:A155	R:R:F177	18.225	2.77	No	Yes	0	9	9
47	R:R:I172	R:R:Y240	26.2338	3.63	No	Yes	0	9	8
48	R:R:E237	R:R:I172	26.8497	6.83	Yes	No	0	9	9
49	R:R:V236	R:R:W233	16.2247	6.13	No	Yes	0	8	9
50	R:R:V236	R:R:Y259	17.4919	3.79	No	No	0	8	8
51	R:R:Y240	R:R:Y259	19.9576	5.96	Yes	No	0	8	8
52	R:R:L349	R:R:L350	17.883	4.15	Yes	Yes	0	9	9
53	R:R:Y141	R:R:Y145	26.7731	5.96	Yes	Yes	1	7	7
54	R:R:I187	R:R:Y145	28.0288	7.25	No	Yes	1	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:Q30	R:R:R289	5.84	0	No	No	5	4	2	1
R:R:E34	R:R:T31	7.06	0	No	Yes	5	5	2	1
R:R:Q285	R:R:T31	8.5	0	No	Yes	3	5	2	1
L:L:D15	R:R:T31	2.89	0	No	Yes	0	5	0	1
R:R:L35	R:R:P89	3.28	0	No	No	5	3	1	1
L:L:F22	R:R:L35	7.31	2	Yes	No	0	5	0	1
L:L:F22	R:R:Y36	8.25	2	Yes	No	0	3	0	1
R:R:R43	R:R:W39	5	2	No	Yes	4	6	2	1
R:R:F65	R:R:W39	3.01	2	Yes	Yes	7	6	2	1
R:R:W39	R:R:Y87	8.68	2	Yes	Yes	6	4	1	1
L:L:F22	R:R:W39	14.03	2	Yes	Yes	0	6	0	1
L:L:L26	R:R:W39	7.97	2	Yes	Yes	0	6	0	1
R:R:P85	R:R:Y42	5.56	2	Yes	Yes	8	7	2	2
R:R:Y42	R:R:Y87	8.94	2	Yes	Yes	7	4	2	1
R:R:F65	R:R:R43	11.76	2	Yes	No	7	4	2	2
R:R:D66	R:R:W71	7.82	2	No	Yes	9	9	2	2
R:R:D66	R:R:R113	7.15	2	No	No	9	6	2	1
L:L:L27	R:R:Y68	10.55	0	Yes	No	0	5	0	1
R:R:R113	R:R:W71	3	2	No	Yes	6	9	1	2
R:R:P85	R:R:Y87	8.34	2	Yes	Yes	8	4	2	1
R:R:L88	R:R:P85	4.93	0	No	Yes	5	8	2	2
L:L:L26	R:R:Y87	3.52	2	Yes	Yes	0	4	0	1
R:R:L88	R:R:W90	5.69	0	No	Yes	5	4	2	1
R:R:P89	R:R:W90	9.46	0	No	Yes	3	4	1	1
R:R:V94	R:R:W90	6.13	0	No	Yes	3	4	2	1
L:L:Q20	R:R:W90	6.57	0	No	Yes	0	4	0	1
L:L:V23	R:R:W90	3.68	0	No	Yes	0	4	0	1
L:L:L27	R:R:R113	3.64	0	Yes	No	0	6	0	1
L:L:L27	R:R:H115	12.86	0	Yes	No	0	7	0	1
R:R:N120	R:R:P121	6.52	0	No	No	3	2	1	2
R:R:E122	R:R:N120	2.63	0	No	No	2	3	2	1
L:L:Q20	R:R:N120	7.92	0	No	No	0	3	0	1
R:R:E122	R:R:F127	7	0	No	Yes	2	2	2	1
R:R:F127	R:R:N124	3.62	0	Yes	No	2	1	1	2
R:R:F127	R:R:Q130	4.68	0	Yes	No	2	3	1	2
L:L:Y13	R:R:F127	8.25	5	Yes	Yes	0	2	0	1
L:L:R17	R:R:L128	3.64	5	No	No	0	3	0	1
R:R:F371	R:R:Q130	10.54	0	No	No	4	3	2	2
L:L:Y13	R:R:R131	8.23	5	Yes	No	0	3	0	1
L:L:R17	R:R:R131	11.73	5	No	No	0	3	0	1
L:L:F6	R:R:L134	3.65	1	No	No	0	5	0	1
L:L:K10	R:R:L134	2.82	1	Yes	No	0	5	0	1
L:L:Y13	R:R:L134	4.69	5	Yes	No	0	5	0	1
L:L:?31	R:R:E135	16.62	1	No	No	0	3	0	1
R:R:Q138	R:R:Y141	7.89	1	Yes	Yes	5	7	1	1
R:R:D191	R:R:Q138	7.83	0	No	Yes	7	5	2	1
L:L:K10	R:R:Q138	9.49	1	Yes	Yes	0	5	0	1
L:L:?31	R:R:Q138	14.31	1	No	Yes	0	5	0	1
R:R:Y141	R:R:Y145	5.96	1	Yes	Yes	7	7	1	1
R:R:I378	R:R:Y141	3.63	1	No	Yes	8	7	1	1
L:L:Q3	R:R:Y141	4.51	1	Yes	Yes	0	7	0	1
L:L:F6	R:R:Y141	6.19	1	No	Yes	0	7	0	1
R:R:I187	R:R:Y145	7.25	1	No	Yes	7	7	1	1
R:R:S382	R:R:Y145	10.17	0	No	Yes	9	7	2	1
L:L:Q3	R:R:Y145	10.15	1	Yes	Yes	0	7	0	1
R:R:I187	R:R:R183	5.01	1	No	Yes	7	8	1	1
R:R:R183	R:R:V227	6.54	1	Yes	No	8	6	1	1
R:R:N230	R:R:R183	9.64	0	No	Yes	9	8	2	1
L:L:H1	R:R:R183	5.64	1	Yes	Yes	0	8	0	1
L:L:Q3	R:R:I187	9.61	1	Yes	No	0	7	0	1
R:R:A219	R:R:R190	2.77	0	No	Yes	6	6	2	1
R:R:Q220	R:R:R190	8.18	0	No	Yes	5	6	2	1
R:R:R190	R:R:T223	7.76	0	Yes	No	6	6	1	2
L:L:T7	R:R:R190	11.64	0	No	Yes	0	6	0	1
R:R:E288	R:R:L194	10.6	0	Yes	No	6	7	1	2
L:L:L14	R:R:P197	9.85	0	No	No	0	4	0	1
R:R:G198	R:R:P199	4.06	0	No	Yes	3	3	2	1
L:L:A18	R:R:P199	3.74	0	No	Yes	0	3	0	1
L:L:H1	R:R:V227	13.84	1	Yes	No	0	6	0	1
R:R:C286	R:R:E288	4.56	0	No	Yes	9	6	2	1
L:L:T7	R:R:E288	4.23	0	No	Yes	0	6	0	1
L:L:S11	R:R:E288	8.62	0	No	Yes	0	6	0	1
L:L:S11	R:R:R289	6.59	0	No	No	0	4	0	1
L:L:D15	R:R:R289	8.34	0	No	No	0	4	0	1
R:R:N290	R:R:W296	24.86	0	No	Yes	6	6	1	1
L:L:S8	R:R:N290	5.96	0	No	No	0	6	0	1
R:R:I299	R:R:W296	7.05	3	No	Yes	7	6	2	1
R:R:R300	R:R:W296	12	0	No	Yes	7	6	2	1
L:L:G4	R:R:W296	2.81	1	No	Yes	0	6	0	1
L:L:T5	R:R:W296	3.64	0	No	Yes	0	6	0	1
R:R:F357	R:R:K373	4.96	1	No	Yes	7	7	2	2
R:R:E377	R:R:F357	32.65	1	No	No	7	7	1	2
R:R:A365	R:R:R370	6.91	0	No	Yes	6	5	2	1
R:R:F371	R:R:R370	6.41	0	No	Yes	4	5	2	1
R:R:K373	R:R:R370	3.71	1	Yes	Yes	7	5	2	1
R:R:L374	R:R:R370	7.29	0	No	Yes	6	5	2	1
L:L:D9	R:R:R370	5.96	0	No	Yes	0	5	0	1
R:R:E377	R:R:K373	2.7	1	No	Yes	7	7	1	2
L:L:?2	R:R:E377	7.61	1	Yes	No	0	7	0	1
L:L:F6	R:R:I378	8.79	1	No	No	0	8	0	1
R:R:V227	R:R:Y231	2.52	1	No	Yes	6	8	1	2
R:R:F65	R:R:M67	2.49	2	Yes	No	7	3	2	1
L:L:E16	R:R:F127	2.33	0	No	Yes	0	2	0	1
R:R:P197	R:R:P199	1.95	0	No	Yes	4	3	1	1
L:L:A19	R:R:P89	1.87	0	No	No	0	3	0	1
R:R:G33	R:R:T31	1.82	0	No	Yes	5	5	2	1
L:L:A18	R:R:A32	1.79	0	No	No	0	4	0	1
L:L:G29	R:R:M67	1.75	0	No	No	0	3	0	1
L:L:D21	R:R:P199	1.61	0	No	Yes	0	3	0	1
R:R:P197	R:R:R196	1.44	0	No	No	4	3	1	2
R:R:E135	R:R:V139	1.43	0	No	No	3	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7FIN_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.63
Number of Linked Nodes	352
Number of Links	383
Number of Hubs	53
Number of Links mediated by Hubs	197
Number of Communities	10
Number of Nodes involved in Communities	70
Number of Links involved in Communities	91

Path Summary
Number Of Nodes in MetaPath	55
Number Of Links MetaPath	54
Number of Shortest Paths	214004
Length Of Smallest Path	3
Average Path Length	21.6871
Length of Longest Path	37
Minimum Path Strength	1.31
Average Path Strength	5.96979
Maximum Path Strength	20.13
Minimum Path Correlation	0.7
Average Path Correlation	0.953489
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	48.7225
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.2326
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• response to stimulus • response to stress • response to wounding • response to axon injury • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • response to metal ion • response to chemical • response to calcium ion • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • negative adaptation of signaling pathway • negative regulation of signaling • negative regulation of biological process • desensitization of G protein-coupled receptor signaling pathway • regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • regulation of response to stimulus • adaptation of signaling pathway • regulation of cell communication • metabolic process • generation of precursor metabolites and energy • response to hexose • response to monosaccharide • response to carbohydrate • response to glucose • response to oxygen-containing compound • gastric inhibitory peptide signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • developmental process • multicellular organism development • multicellular organismal process • pancreas development • endocrine system development • anatomical structure development • animal organ development • endocrine pancreas development • system development • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • cell surface receptor signaling pathway • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to lipid • response to fatty acid • response to nutrient levels • response to nutrient • positive regulation of cell communication • positive regulation of establishment of protein localization • positive regulation of insulin secretion • positive regulation of peptide hormone secretion • positive regulation of protein localization • positive regulation of biological process • positive regulation of secretion by cell • positive regulation of protein transport • positive regulation of hormone secretion • positive regulation of secretion • positive regulation of cellular process • positive regulation of peptide secretion • positive regulation of protein secretion • positive regulation of transport • positive regulation of signaling • cellular anatomical structure • membrane • cell periphery • plasma membrane • peptide hormone receptor binding • protein binding • binding • corticotropin-releasing hormone receptor binding • signaling receptor binding • G protein-coupled receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • mu-type opioid receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • adrenergic receptor binding • D1 dopamine receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • ionotropic glutamate receptor binding • glutamate receptor binding • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • insulin-like growth factor receptor binding • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • intracellular anatomical structure • cytoplasm • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding • response to ketone • response to prostaglandin • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• FnI-like domain • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• FnI-like domain • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	AIB
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	AIB
Name	2-aminoisobutyric acid
Synonyms	α,α-dimethylglycine
Identifier
Formula	C4 H9 N O2
Molecular Weight	103.12
SMILES
PubChem	5245672
Formal Charge	0
Total Atoms	16
Total Chiral Atoms	0
Total Bonds	15
Total Aromatic Bonds	0


Code	GGL
PDB Residues	L:L:?31
Environment Details	Open EMBL-EBI Page
Code	GGL
Name	Glutamic acid
Synonyms	L-Glutamic acid
Identifier
Formula	C5 H9 N O4
Molecular Weight	147.129
SMILES
PubChem	44272391
Formal Charge	0
Total Atoms	19
Total Chiral Atoms	1
Total Bonds	18
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P48546
Sequence	>7FIN_nogp_Chain_R Q T A G E L Y Q R W E R Y R R E C Q E T L A A A A C N G S F D M Y V C W D Y A A P N A T A R A S C P W Y L P W H H H V A A G F V L R Q C G S D G Q W G L W R D H T Q C E N P E K N E A F L D Q R L I L E R L Q V M Y T V G Y S L S L A T L L L A L L I L S L F R R L H C T R N Y I H I N L F T S F M L R A A A I L S R D R L L P R P G P Y L G D Q A L A L W N Q A L A A C R T A Q I V T Q Y C V G A N Y T W L L V E G V Y L H S L L V L V G G S E E G H F R Y Y L L L G W G A P A L F V I P W V I V R Y L Y E N T Q C W E R N E V K A I W W I I R T P I L M T I L I N F L I F I R I L G I L L S K L R T R Q M R C R D Y R L R L A R S T L F L V P L L G V H E V V F A P V T E E Q A R G A L R F A K L G F E I F L S S F Q G F L V S V L Y C F I N K E V Q S E I R R G W H H C R L R R S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YW4	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ22	3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW4 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-		3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8WA3	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	2.86	2024-03-06	10.1038/s41421-024-00649-0
	8WA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		2.86	2024-03-06	10.1038/s41421-024-00649-0
	8ITM	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.13	2023-10-18	10.1073/pnas.2306145120
	8ITM (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.13	2023-10-18	10.1073/pnas.2306145120
	8ITL	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.23	2023-10-18	10.1073/pnas.2306145120
	8ITL (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.23	2023-10-18	10.1073/pnas.2306145120
	7RBT	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	PubChem 163183774	chim(NtGi1-Gs)/β1/γ2	3.08	2022-04-13	10.1073/pnas.2116506119
	7RBT (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	PubChem 163183774		3.08	2022-04-13	10.1073/pnas.2116506119
	7RA3	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	chim(NtGi1-Gs)/β1/γ2	3.24	2022-04-13	10.1073/pnas.2116506119
	7RA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		3.24	2022-04-13	10.1073/pnas.2116506119
	7VAB	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-03-02	10.1038/s41467-022-28683-0
	7VAB (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-		3.2	2022-03-02	10.1038/s41467-022-28683-0
	7FIY	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	10.1038/s41467-022-28683-0
	7FIY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	10.1038/s41467-022-28683-0
	7FIN	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-	Gs/β1/γ2	3.1	2022-02-23	10.1038/s41467-022-28683-0
	7FIN (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-		3.1	2022-02-23	10.1038/s41467-022-28683-0
	7DTY	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	Gs/β1/γ2	2.98	2021-08-04	10.7554/eLife.68719
	7DTY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		2.98	2021-08-04	10.7554/eLife.68719

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Download 7FIN_nogp.zip

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