psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A126	R:R:Q130	3.03	No	Yes	0	1	3
2	R:R:F127	R:R:Q130	5.86	No	Yes	2	2	3
3	R:R:F127	R:R:R131	7.48	No	Yes	2	2	3
4	R:R:L128	R:R:L132	5.54	No	No	0	3	3
5	R:R:Q130	R:R:R131	5.84	Yes	Yes	2	3	3
6	R:R:I133	R:R:Q130	4.12	No	Yes	0	4	3
7	R:R:Q364	R:R:R131	3.5	No	Yes	0	5	3
8	R:R:F371	R:R:I133	8.79	No	No	0	4	4
9	R:R:L134	R:R:L137	6.92	No	No	3	5	6
10	R:R:L134	R:R:Q364	11.98	No	No	0	5	5
11	R:R:L134	R:R:L374	5.54	No	No	3	5	6
12	R:R:L137	R:R:L374	5.54	No	No	3	6	6
13	R:R:I378	R:R:L137	4.28	Yes	No	0	8	6
14	R:R:Q138	R:R:Y141	4.51	No	Yes	0	5	7
15	R:R:F379	R:R:M140	13.68	No	No	0	6	6
16	R:R:Y141	R:R:Y145	19.86	Yes	Yes	4	7	7
17	R:R:I187	R:R:Y141	3.63	No	Yes	4	7	7
18	R:R:I378	R:R:Y141	9.67	Yes	Yes	0	8	7
19	R:R:S146	R:R:V143	3.23	No	No	0	7	5
20	R:R:G144	R:R:S382	3.71	No	Yes	0	8	9
21	R:R:I187	R:R:Y145	8.46	No	Yes	4	7	7
22	R:R:L188	R:R:Y145	7.03	No	Yes	0	7	7
23	R:R:S381	R:R:Y145	5.09	No	Yes	0	5	7
24	R:R:F386	R:R:L147	17.05	Yes	No	0	5	5
25	R:R:L152	R:R:S148	4.5	Yes	No	0	9	9
26	R:R:F386	R:R:T151	9.08	Yes	No	5	5	7
27	R:R:S389	R:R:T151	7.99	No	No	5	8	7
28	R:R:F177	R:R:L152	4.87	Yes	Yes	0	9	9
29	R:R:F180	R:R:L152	7.31	Yes	Yes	0	8	9
30	R:R:L152	R:R:M181	4.24	Yes	Yes	0	9	7
31	R:R:L153	R:R:M181	5.65	No	Yes	0	3	7
32	R:R:A155	R:R:F177	5.55	No	Yes	0	9	9
33	R:R:F177	R:R:L156	3.65	Yes	No	0	9	6
34	R:R:L156	R:R:M181	7.07	No	Yes	0	6	7
35	R:R:F162	R:R:I158	11.3	No	No	0	7	8
36	R:R:I174	R:R:L159	7.14	No	No	0	7	8
37	R:R:C393	R:R:L159	4.76	No	No	0	9	8
38	R:R:I174	R:R:S160	3.1	No	No	0	7	3
39	R:R:E402	R:R:F162	10.49	No	No	0	8	7
40	R:R:F162	R:R:I403	7.54	No	No	0	7	5
41	R:R:E402	R:R:R164	4.65	No	No	0	8	7
42	R:R:L165	R:R:N170	6.87	No	No	0	9	9
43	R:R:E398	R:R:L165	6.63	No	No	0	9	9
44	R:R:H166	R:R:Y171	11.98	No	No	0	7	6
45	R:R:C167	R:R:N170	4.72	No	No	0	8	9
46	R:R:I172	R:R:T168	3.04	No	Yes	8	9	8
47	R:R:T168	R:R:Y240	8.74	Yes	Yes	8	8	8
48	R:R:F256	R:R:T168	5.19	No	Yes	0	5	8
49	R:R:H173	R:R:R169	15.8	No	No	0	9	9
50	R:R:N396	R:R:R169	12.05	No	No	7	9	9
51	R:R:E398	R:R:R169	4.65	No	No	7	9	9
52	R:R:F256	R:R:Y171	7.22	No	No	0	5	6
53	R:R:I172	R:R:Y240	6.04	No	Yes	8	9	8
54	R:R:H173	R:R:Y392	27.22	No	Yes	0	9	8
55	R:R:N175	R:R:W233	14.69	No	Yes	0	9	9
56	R:R:F256	R:R:N175	3.62	No	No	0	5	9
57	R:R:F180	R:R:L176	4.87	Yes	No	0	8	9
58	R:R:L176	R:R:Y392	4.69	No	Yes	0	9	8
59	R:R:F177	R:R:Y392	6.19	Yes	Yes	0	9	8
60	R:R:M181	R:R:T178	3.01	Yes	No	0	7	3
61	R:R:A229	R:R:S179	3.42	No	No	1	8	9
62	R:R:N230	R:R:S179	5.96	No	No	0	9	9
63	R:R:S179	R:R:W264	4.94	No	Yes	1	9	9
64	R:R:F180	R:R:N230	18.12	Yes	No	0	8	9
65	R:R:F180	R:R:Q384	5.86	Yes	No	6	8	9
66	R:R:F180	R:R:G385	3.01	Yes	No	6	8	9
67	R:R:F180	R:R:V388	5.24	Yes	No	0	8	9
68	R:R:C226	R:R:R183	5.57	No	Yes	0	6	8
69	R:R:R183	R:R:V227	3.92	Yes	No	0	8	6
70	R:R:N230	R:R:R183	12.05	No	Yes	0	9	8
71	R:R:E354	R:R:R183	5.82	No	Yes	0	7	8
72	R:R:Q384	R:R:R183	3.5	No	Yes	0	9	8
73	R:R:A186	R:R:V222	3.39	No	No	0	6	5
74	R:R:I187	R:R:R190	3.76	No	Yes	0	7	6
75	R:R:Q220	R:R:R190	10.51	No	Yes	0	5	6
76	R:R:R190	R:R:T223	6.47	Yes	No	0	6	6
77	R:R:D191	R:R:R192	4.76	No	No	0	7	4
78	R:R:L194	R:R:P195	4.93	No	No	0	7	3
79	R:R:L194	R:R:W287	3.42	No	No	0	7	9
80	R:R:A212	R:R:N210	3.13	No	No	0	6	4
81	R:R:C216	R:R:C286	7.28	No	No	0	9	9
82	R:R:R217	R:R:R278	11.73	No	No	0	8	8
83	R:R:N283	R:R:R217	3.62	No	No	0	6	8
84	R:R:Q220	R:R:Q224	3.84	No	No	0	5	6
85	R:R:Q220	R:R:W287	18.62	No	No	0	5	9
86	R:R:I221	R:R:W274	3.52	No	Yes	0	5	8
87	R:R:I221	R:R:V275	4.61	No	No	0	5	6
88	R:R:Q224	R:R:W274	6.57	No	Yes	0	6	8
89	R:R:W264	R:R:Y225	8.68	Yes	No	0	9	8
90	R:R:G228	R:R:P267	4.06	No	Yes	0	5	9
91	R:R:A229	R:R:W264	3.89	No	Yes	1	8	9
92	R:R:A229	R:R:P267	3.74	No	Yes	0	8	9
93	R:R:I303	R:R:Y231	7.25	No	No	0	7	8
94	R:R:V355	R:R:Y231	10.09	No	No	0	5	8
95	R:R:G263	R:R:T232	3.64	No	No	0	9	6
96	R:R:A266	R:R:T232	3.36	No	No	0	4	6
97	R:R:P267	R:R:T232	10.49	Yes	No	0	9	6
98	R:R:V236	R:R:W233	7.36	No	Yes	0	8	9
99	R:R:L260	R:R:W233	3.42	No	Yes	1	6	9
100	R:R:G263	R:R:W233	7.04	No	Yes	0	9	9
101	R:R:W233	R:R:W264	17.81	Yes	Yes	1	9	9
102	R:R:L234	R:R:P348	6.57	No	No	0	9	9
103	R:R:L235	R:R:N310	10.98	Yes	No	0	8	9
104	R:R:E237	R:R:G238	4.91	No	No	0	9	9
105	R:R:E237	R:R:Y392	7.86	No	Yes	0	9	8
106	R:R:F314	R:R:G238	3.01	No	No	0	9	9
107	R:R:L244	R:R:Y240	4.69	No	Yes	0	8	8
108	R:R:Y240	R:R:Y259	6.95	Yes	No	0	8	8
109	R:R:I317	R:R:L241	4.28	No	No	0	9	9
110	R:R:H242	R:R:V246	11.07	Yes	No	0	8	7
111	R:R:H242	R:R:R316	3.39	Yes	No	0	8	8
112	R:R:I320	R:R:L245	5.71	No	No	0	8	8
113	R:R:E252	R:R:H255	24.62	No	No	0	7	4
114	R:R:H255	R:R:Y258	6.53	No	No	0	4	3
115	R:R:L260	R:R:W264	3.42	No	Yes	1	6	9
116	R:R:G263	R:R:L262	3.42	No	No	0	9	6
117	R:R:F270	R:R:I299	8.79	No	No	0	5	7
118	R:R:F270	R:R:P302	28.9	No	No	0	5	9
119	R:R:I299	R:R:V271	3.07	No	No	0	7	6
120	R:R:I272	R:R:P273	5.08	No	No	0	2	4
121	R:R:R278	R:R:W274	6	No	Yes	0	8	8
122	R:R:I298	R:R:W274	4.7	No	Yes	0	8	8
123	R:R:I299	R:R:W274	7.05	No	Yes	0	7	8
124	R:R:R278	R:R:T284	3.88	No	No	0	8	4
125	R:R:N283	R:R:Y279	3.49	No	No	0	6	3
126	R:R:E282	R:R:Y281	4.49	No	No	0	5	3
127	R:R:E282	R:R:I295	4.1	No	Yes	0	5	3
128	R:R:C286	R:R:W287	5.22	No	No	0	9	9
129	R:R:E288	R:R:R289	3.49	No	No	0	6	4
130	R:R:N290	R:R:W296	11.3	No	No	0	6	6
131	R:R:E291	R:R:V292	5.7	No	No	0	4	6
132	R:R:I295	R:R:V292	6.14	Yes	No	0	3	6
133	R:R:W296	R:R:W297	6.56	No	No	0	6	7
134	R:R:R300	R:R:W296	12	Yes	No	0	7	6
135	R:R:T301	R:R:W297	3.64	No	No	0	4	7
136	R:R:I303	R:R:R300	3.76	No	Yes	0	7	7
137	R:R:R300	R:R:V355	9.15	Yes	No	0	7	5
138	R:R:P302	R:R:T301	3.5	No	No	0	9	4
139	R:R:M305	R:R:T301	3.01	No	No	0	4	4
140	R:R:I307	R:R:L349	9.99	No	Yes	0	7	9
141	R:R:I307	R:R:V352	6.14	No	No	0	7	6
142	R:R:F311	R:R:I315	8.79	No	No	0	6	5
143	R:R:F311	R:R:L349	3.65	No	Yes	0	6	9
144	R:R:F314	R:R:L346	8.53	No	No	0	9	9
145	R:R:I320	R:R:R316	3.76	No	No	0	8	8
146	R:R:L318	R:R:R338	3.64	Yes	No	0	7	9
147	R:R:L318	R:R:S342	4.5	Yes	No	0	7	9
148	R:R:L321	R:R:L325	4.15	No	No	0	9	7
149	R:R:L322	R:R:R338	8.5	No	No	0	5	9
150	R:R:D334	R:R:L325	9.5	No	No	0	6	7
151	R:R:R326	R:R:Y335	13.38	No	No	0	7	5
152	R:R:M330	R:R:R328	4.96	No	No	0	5	6
153	R:R:D334	R:R:M330	4.16	No	No	0	6	5
154	R:R:R331	R:R:R333	19.19	No	No	0	5	6
155	R:R:L337	R:R:R341	4.86	No	No	0	7	9
156	R:R:L339	R:R:S342	4.5	No	No	0	9	9
157	R:R:A340	R:R:R341	4.15	No	No	0	8	9
158	R:R:S342	R:R:T343	3.2	No	No	0	9	9
159	R:R:F345	R:R:L344	3.65	No	No	0	8	8
160	R:R:L344	R:R:L391	12.46	No	No	0	8	7
161	R:R:L346	R:R:L349	4.15	No	Yes	0	9	9
162	R:R:P348	R:R:V347	3.53	No	No	0	9	8
163	R:R:L387	R:R:V347	8.94	No	No	0	6	8
164	R:R:P348	R:R:V388	3.53	No	No	0	9	9
165	R:R:H353	R:R:L350	7.71	No	No	0	8	9
166	R:R:E354	R:R:S381	10.06	No	No	0	7	5
167	R:R:F357	R:R:K373	7.44	No	No	0	7	7
168	R:R:E377	R:R:F357	13.99	No	No	0	7	7
169	R:R:A358	R:R:P359	3.74	No	No	0	6	5
170	R:R:L374	R:R:V360	5.96	No	No	0	6	4
171	R:R:E362	R:R:T361	4.23	No	No	0	5	7
172	R:R:G375	R:R:I378	3.53	No	Yes	0	5	8
173	R:R:F376	R:R:L380	3.65	No	No	0	4	7
174	R:R:E377	R:R:I378	4.1	No	Yes	0	7	8
175	R:R:G385	R:R:Q384	4.93	No	No	6	9	9
176	R:R:F386	R:R:S389	3.96	Yes	No	5	5	8
177	R:R:F386	R:R:V390	5.24	Yes	No	0	5	5
178	R:R:L391	R:R:V390	5.96	No	No	0	7	5
179	R:R:F394	R:R:V390	6.55	No	No	0	8	5
180	R:R:E398	R:R:N396	13.15	No	No	7	9	9
181	R:R:H408	R:R:R404	5.64	No	No	0	4	6
182	R:R:H409	R:R:R405	18.05	No	No	0	7	8
183	R:R:H408	R:R:W407	7.41	No	No	0	4	5
184	R:R:R411	R:R:W407	18.99	No	No	0	4	5
185	R:R:L152	R:R:S389	3	Yes	No	0	9	8
186	R:R:G406	R:R:R405	3	No	No	0	5	8
187	R:R:L165	R:R:V399	2.98	No	No	0	9	9
188	R:R:L235	R:R:V239	2.98	Yes	No	0	8	7
189	R:R:C393	R:R:H173	2.95	No	No	0	9	9
190	R:R:L235	R:R:T306	2.95	Yes	No	0	8	7
191	R:R:I309	R:R:I313	2.94	No	No	0	6	8
192	R:R:I158	R:R:L159	2.85	No	No	0	8	8
193	R:R:I309	R:R:L235	2.85	No	Yes	0	6	8
194	R:R:I395	R:R:L391	2.85	No	No	0	5	7
195	R:R:I295	R:R:N290	2.83	Yes	No	0	3	6
196	R:R:I307	R:R:N310	2.83	No	No	0	7	9
197	R:R:E253	R:R:T168	2.82	No	Yes	0	5	8
198	R:R:E288	R:R:T284	2.82	No	No	0	6	4
199	R:R:A219	R:R:R190	2.77	No	Yes	0	6	6
200	R:R:A368	R:R:F371	2.77	No	No	0	1	4
201	R:R:L213	R:R:N210	2.75	No	No	0	4	4
202	R:R:A268	R:R:Y225	2.67	No	No	0	3	8
203	R:R:E237	R:R:L241	2.65	No	No	0	9	9
204	R:R:H242	R:R:I313	2.65	Yes	No	0	8	8
205	R:R:H242	R:R:I317	2.65	Yes	No	0	8	9
206	R:R:F379	R:R:S382	2.64	No	Yes	0	6	9
207	R:R:R300	R:R:V356	2.62	Yes	No	0	7	6
208	R:R:S382	R:R:Y145	2.54	Yes	Yes	0	9	7
209	R:R:S243	R:R:Y259	2.54	No	No	0	7	8
210	R:R:L304	R:R:R300	2.43	No	Yes	0	4	7
211	R:R:L322	R:R:R326	2.43	No	No	0	5	7
212	R:R:L344	R:R:R341	2.43	No	No	0	8	9
213	R:R:L280	R:R:Y279	2.34	No	No	0	3	3
214	R:R:K293	R:R:W297	2.32	No	No	0	5	7
215	R:R:L182	R:R:W264	2.28	No	Yes	0	7	9
216	R:R:H255	R:R:Y259	2.18	No	No	0	4	8
217	R:R:R333	R:R:R336	2.13	No	No	0	6	6
218	R:R:G249	R:R:G250	2.11	No	No	0	7	6
219	R:R:G265	R:R:P267	2.03	No	Yes	0	6	9
220	R:R:G250	R:R:S251	1.86	No	No	0	6	7
221	R:R:G144	R:R:V143	1.84	No	No	0	8	5
222	R:R:G249	R:R:V248	1.84	No	No	0	7	7
223	R:R:A186	R:R:C226	1.81	No	No	0	6	6
224	R:R:A184	R:R:S148	1.71	No	No	0	8	9
225	R:R:G319	R:R:L322	1.71	No	No	0	8	5
226	R:R:A294	R:R:V292	1.7	No	No	0	3	6
227	R:R:I298	R:R:P273	1.69	No	No	0	8	4
228	R:R:E252	R:R:G254	1.64	No	No	0	7	5
229	R:R:E354	R:R:G351	1.64	No	No	0	7	9
230	R:R:V139	R:R:V143	1.6	No	No	0	3	5
231	R:R:S323	R:R:T327	1.6	No	No	0	7	6
232	R:R:T218	R:R:V222	1.59	No	No	0	3	5
233	R:R:T361	R:R:V360	1.59	No	No	0	7	4
234	R:R:A184	R:R:L149	1.58	No	No	0	8	6
235	R:R:A215	R:R:L193	1.58	No	No	0	3	5
236	R:R:A372	R:R:L369	1.58	No	No	0	5	4
237	R:R:I276	R:R:V275	1.54	No	No	0	3	6
238	R:R:I295	R:R:V277	1.54	Yes	No	0	3	5
239	R:R:I298	R:R:V277	1.54	No	No	0	8	5
240	R:R:C286	R:R:Q285	1.53	No	No	0	9	3
241	R:R:L247	R:R:S243	1.5	No	No	0	5	7
242	R:R:G367	R:R:R366	1.5	No	No	0	4	5
243	R:R:G367	R:R:R370	1.5	No	No	0	4	5
244	R:R:I320	R:R:K324	1.45	No	No	0	8	9
245	R:R:I317	R:R:L318	1.43	No	Yes	0	9	7
246	R:R:Q400	R:R:V399	1.43	No	No	0	8	9
247	R:R:E363	R:R:T361	1.41	No	No	0	5	7
248	R:R:L318	R:R:L321	1.38	Yes	No	0	7	9
249	R:R:L325	R:R:L337	1.38	No	No	0	7	7
250	R:R:A340	R:R:R336	1.38	No	No	0	8	6
251	R:R:L349	R:R:L350	1.38	Yes	No	0	9	9
252	R:R:E125	R:R:L128	1.33	No	No	0	3	3
253	R:R:L213	R:R:Q285	1.33	No	No	0	4	3
254	R:R:F383	R:R:S382	1.32	No	Yes	0	6	9
255	R:R:D129	R:R:E125	1.3	No	No	0	1	3
256	R:R:F394	R:R:L154	1.22	No	No	0	8	5
257	R:R:F127	R:R:N124	1.21	No	No	0	2	1
258	R:R:L132	R:R:R131	1.21	No	Yes	0	3	3
259	R:R:L193	R:R:R192	1.21	No	No	0	5	4
260	R:R:E135	R:R:R136	1.16	No	No	0	3	4
261	R:R:H166	R:R:R163	1.13	No	No	0	7	8
262	R:R:R411	R:R:R414	1.07	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Q130	4.7125	4	2	3
2	R:R:R131	4.5075	4	2	3
3	R:R:Y141	9.4175	4	4	7
4	R:R:Y145	8.596	5	4	7
5	R:R:L152	4.784	5	0	9
6	R:R:T168	4.9475	4	8	8
7	R:R:F177	5.065	4	0	9
8	R:R:F180	7.40167	6	6	8
9	R:R:M181	4.9925	4	0	7
10	R:R:R183	6.172	5	0	8
11	R:R:R190	5.8775	4	0	6
12	R:R:W233	10.064	5	1	9
13	R:R:L235	4.94	4	0	8
14	R:R:Y240	6.605	4	8	8
15	R:R:H242	4.94	4	0	8
16	R:R:W264	6.83667	6	1	9
17	R:R:P267	5.08	4	0	9
18	R:R:W274	5.568	5	0	8
19	R:R:I295	3.6525	4	0	3
20	R:R:R300	5.992	5	0	7
21	R:R:L318	2.7375	4	0	7
22	R:R:L349	4.7925	4	0	9
23	R:R:I378	5.395	4	0	8
24	R:R:S382	2.5525	4	0	9
25	R:R:F386	8.8325	4	5	5
26	R:R:Y392	11.49	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q364	R:R:R131	17.3862	3.5	No	Yes	0	5	3
2	R:R:L134	R:R:Q364	18.6959	11.98	No	No	0	5	5
3	R:R:L134	R:R:L137	19.7577	6.92	No	No	3	5	6
4	R:R:I378	R:R:L137	28.0088	4.28	Yes	No	0	8	6
5	R:R:I378	R:R:Y141	34.5011	9.67	Yes	Yes	0	8	7
6	R:R:Y141	R:R:Y145	30.2212	19.86	Yes	Yes	4	7	7
7	R:R:S382	R:R:Y145	11.7452	2.54	Yes	Yes	0	9	7
8	R:R:S381	R:R:Y145	98.1103	5.09	No	Yes	0	5	7
9	R:R:E354	R:R:S381	98.7605	10.06	No	No	0	7	5
10	R:R:E354	R:R:R183	100	5.82	No	Yes	0	7	8
11	R:R:N230	R:R:R183	59.4134	12.05	No	Yes	0	9	8
12	R:R:F180	R:R:N230	58.4592	18.12	Yes	No	0	8	9
13	R:R:F180	R:R:L152	31.7648	7.31	Yes	Yes	0	8	9
14	R:R:L152	R:R:S389	22.8823	3	Yes	No	0	9	8
15	R:R:F386	R:R:S389	20.0992	3.96	Yes	No	5	5	8
16	R:R:Q384	R:R:R183	44.4923	3.5	No	Yes	0	9	8
17	R:R:F180	R:R:Q384	43.9918	5.86	Yes	No	6	8	9
18	R:R:F180	R:R:L176	66.6776	4.87	Yes	No	0	8	9
19	R:R:L176	R:R:Y392	65.7281	4.69	No	Yes	0	9	8
20	R:R:H173	R:R:Y392	26.5868	27.22	No	Yes	0	9	8
21	R:R:C393	R:R:H173	13.6302	2.95	No	No	0	9	9
22	R:R:C393	R:R:L159	12.1381	4.76	No	No	0	9	8
23	R:R:H173	R:R:R169	12.1989	15.8	No	No	0	9	9
24	R:R:N230	R:R:S179	30.3662	5.96	No	No	0	9	9
25	R:R:S179	R:R:W264	24.0376	4.94	No	Yes	1	9	9
26	R:R:W233	R:R:W264	20.2021	17.81	Yes	Yes	1	9	9
27	R:R:N175	R:R:W233	17.1336	14.69	No	Yes	0	9	9
28	R:R:F256	R:R:N175	16.1981	3.62	No	No	0	5	9
29	R:R:F256	R:R:T168	12.3626	5.19	No	Yes	0	5	8
30	R:R:I187	R:R:R190	66.6682	3.76	No	Yes	0	7	6
31	R:R:Q220	R:R:R190	63.5951	10.51	No	Yes	0	5	6
32	R:R:Q220	R:R:W287	13.1718	18.62	No	No	0	5	9
33	R:R:Q220	R:R:Q224	52.7433	3.84	No	No	0	5	6
34	R:R:Q224	R:R:W274	51.6067	6.57	No	Yes	0	6	8
35	R:R:R278	R:R:W274	11.7358	6	No	Yes	0	8	8
36	R:R:I298	R:R:W274	26.3764	4.7	No	Yes	0	8	8
37	R:R:I298	R:R:V277	22.4052	1.54	No	No	0	8	5
38	R:R:I295	R:R:V277	21.0814	1.54	Yes	No	0	3	5
39	R:R:I295	R:R:N290	12.9987	2.83	Yes	No	0	3	6
40	R:R:N290	R:R:W296	11.6282	11.3	No	No	0	6	6
41	R:R:R300	R:R:W296	10.2764	12	Yes	No	0	7	6
42	R:R:E237	R:R:Y392	51.7283	7.86	No	Yes	0	9	8
43	R:R:E237	R:R:L241	36.882	2.65	No	No	0	9	9
44	R:R:I317	R:R:L241	35.6565	4.28	No	No	0	9	9
45	R:R:H242	R:R:I317	16.4835	2.65	Yes	No	0	8	9
46	R:R:E237	R:R:G238	15.7304	4.91	No	No	0	9	9
47	R:R:F314	R:R:G238	14.2991	3.01	No	No	0	9	9
48	R:R:F314	R:R:L346	12.8678	8.53	No	No	0	9	9
49	R:R:L346	R:R:L349	11.4365	4.15	No	Yes	0	9	9
50	R:R:I299	R:R:W274	11.2306	7.05	No	Yes	0	7	8
51	R:R:I317	R:R:L318	21.4603	1.43	No	Yes	0	9	7
52	R:R:F386	R:R:V390	17.5546	5.24	Yes	No	0	5	5
53	R:R:L391	R:R:V390	13.822	5.96	No	No	0	7	5
54	R:R:L344	R:R:L391	11.4177	12.46	No	No	0	8	7
55	R:R:I187	R:R:Y145	60.8681	8.46	No	Yes	4	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8ITM_nogp

PDB Summary
PDB	8ITM_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.01
Number of Linked Nodes	256
Number of Links	262
Number of Hubs	26
Number of Links mediated by Hubs	104
Number of Communities	8
Number of Nodes involved in Communities	26
Number of Links involved in Communities	27

Path Summary
Number Of Nodes in MetaPath	56
Number Of Links MetaPath	55
Number of Shortest Paths	35485
Length Of Smallest Path	3
Average Path Length	14.9901
Length of Longest Path	30
Minimum Path Strength	1.315
Average Path Strength	6.83275
Maximum Path Strength	21.51
Minimum Path Correlation	0.7
Average Path Correlation	0.940869
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	51.7608
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.2354
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• response to stimulus • response to stress • response to wounding • response to axon injury • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • response to metal ion • response to chemical • response to calcium ion • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • negative adaptation of signaling pathway • negative regulation of signaling • negative regulation of biological process • desensitization of G protein-coupled receptor signaling pathway • regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • regulation of response to stimulus • adaptation of signaling pathway • regulation of cell communication • metabolic process • generation of precursor metabolites and energy • response to hexose • response to monosaccharide • response to carbohydrate • response to glucose • response to oxygen-containing compound • gastric inhibitory peptide signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • developmental process • multicellular organism development • multicellular organismal process • pancreas development • endocrine system development • anatomical structure development • animal organ development • endocrine pancreas development • system development • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • cell surface receptor signaling pathway • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to lipid • response to fatty acid • response to nutrient levels • response to nutrient • positive regulation of cell communication • positive regulation of establishment of protein localization • positive regulation of insulin secretion • positive regulation of peptide hormone secretion • positive regulation of protein localization • positive regulation of biological process • positive regulation of secretion by cell • positive regulation of protein transport • positive regulation of hormone secretion • positive regulation of secretion • positive regulation of cellular process • positive regulation of peptide secretion • positive regulation of protein secretion • positive regulation of transport • positive regulation of signaling • cellular anatomical structure • membrane • cell periphery • plasma membrane • peptide hormone receptor binding • protein binding • binding • corticotropin-releasing hormone receptor binding • signaling receptor binding • G protein-coupled receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • mu-type opioid receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • adrenergic receptor binding • D1 dopamine receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • ionotropic glutamate receptor binding • glutamate receptor binding • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • molecular function regulator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • insulin-like growth factor receptor binding • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • intracellular anatomical structure • cytoplasm • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding • response to ketone • response to prostaglandin • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P48546
Sequence	>8ITM_nogp_Chain_R N E A F L D Q R L I L E R L Q V M Y T V G Y S L S L A T L L L A L L I L S L F R R L H C T R N Y I H I N L F T S F M L R A A A I L S R D R L L P N Q A L A A C R T A Q I V T Q Y C V G A N Y T W L L V E G V Y L H S L L V L V G G S E E G H F R Y Y L L L G W G A P A L F V I P W V I V R Y L Y E N T Q C W E R N E V K A I W W I I R T P I L M T I L I N F L I F I R I L G I L L S K L R T R Q M R C R D Y R L R L A R S T L F L V P L L G V H E V V F A P V T E E Q A R G A L R F A K L G F E I F L S S F Q G F L V S V L Y C F I N K E V Q S E I R R G W H H C R L R R S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7DTY	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	Gs/β1/γ2	2.98	2021-08-04	doi.org/10.7554/eLife.68719
	7DTY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		2.98	2021-08-04	doi.org/10.7554/eLife.68719
	7FIN	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-	Gs/β1/γ2	3.1	2022-02-23	doi.org/10.1038/s41467-022-28683-0
	7FIN (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-		3.1	2022-02-23	doi.org/10.1038/s41467-022-28683-0
	7FIY	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VAB	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide (non-acylated)	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VAB (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide (non-acylated)	-		3.2	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7RA3	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	chim(NtGi1-Gs)/β1/γ2	3.24	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		3.24	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RBT	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	LSN3556672	chim(NtGi1-Gs)/β1/γ2	3.08	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RBT (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	LSN3556672		3.08	2022-04-13	doi.org/10.1073/pnas.2116506119
	8ITL	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.23	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITL (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.23	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITM	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.13	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITM (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.13	2023-10-18	doi.org/10.1073/pnas.2306145120
	8YW4	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ2	3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW4 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-		3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8WA3	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	2.86	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		2.86	2024-03-06	doi.org/10.1038/s41421-024-00649-0

there is no ligand in network 8ITM_nogp

Data downloads are temporarily suspended for technical reasons. We apologize for the inconvenience.

Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.