psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A126	R:R:Q130	3.03	No	Yes	0	1	3
2	R:R:F127	R:R:Q130	5.86	No	Yes	2	2	3
3	R:R:F127	R:R:R131	7.48	No	Yes	2	2	3
4	R:R:L128	R:R:L132	5.54	No	No	0	3	3
5	R:R:Q130	R:R:R131	5.84	Yes	Yes	2	3	3
6	R:R:I133	R:R:Q130	4.12	No	Yes	0	4	3
7	R:R:Q364	R:R:R131	3.5	No	Yes	0	5	3
8	R:R:F371	R:R:I133	8.79	No	No	0	4	4
9	R:R:L134	R:R:L137	6.92	No	No	3	5	6
10	R:R:L134	R:R:Q364	11.98	No	No	0	5	5
11	R:R:L134	R:R:L374	5.54	No	No	3	5	6
12	R:R:L137	R:R:L374	5.54	No	No	3	6	6
13	R:R:I378	R:R:L137	4.28	Yes	No	0	8	6
14	R:R:Q138	R:R:Y141	4.51	No	Yes	0	5	7
15	R:R:F379	R:R:M140	13.68	No	No	0	6	6
16	R:R:Y141	R:R:Y145	19.86	Yes	Yes	4	7	7
17	R:R:I187	R:R:Y141	3.63	No	Yes	4	7	7
18	R:R:I378	R:R:Y141	9.67	Yes	Yes	0	8	7
19	R:R:S146	R:R:V143	3.23	No	No	0	7	5
20	R:R:G144	R:R:S382	3.71	No	Yes	0	8	9
21	R:R:I187	R:R:Y145	8.46	No	Yes	4	7	7
22	R:R:L188	R:R:Y145	7.03	No	Yes	0	7	7
23	R:R:S381	R:R:Y145	5.09	No	Yes	0	5	7
24	R:R:F386	R:R:L147	17.05	Yes	No	0	5	5
25	R:R:L152	R:R:S148	4.5	Yes	No	0	9	9
26	R:R:F386	R:R:T151	9.08	Yes	No	5	5	7
27	R:R:S389	R:R:T151	7.99	No	No	5	8	7
28	R:R:F177	R:R:L152	4.87	Yes	Yes	0	9	9
29	R:R:F180	R:R:L152	7.31	Yes	Yes	0	8	9
30	R:R:L152	R:R:M181	4.24	Yes	Yes	0	9	7
31	R:R:L153	R:R:M181	5.65	No	Yes	0	3	7
32	R:R:A155	R:R:F177	5.55	No	Yes	0	9	9
33	R:R:F177	R:R:L156	3.65	Yes	No	0	9	6
34	R:R:L156	R:R:M181	7.07	No	Yes	0	6	7
35	R:R:F162	R:R:I158	11.3	No	No	0	7	8
36	R:R:I174	R:R:L159	7.14	No	No	0	7	8
37	R:R:C393	R:R:L159	4.76	No	No	0	9	8
38	R:R:I174	R:R:S160	3.1	No	No	0	7	3
39	R:R:E402	R:R:F162	10.49	No	No	0	8	7
40	R:R:F162	R:R:I403	7.54	No	No	0	7	5
41	R:R:E402	R:R:R164	4.65	No	No	0	8	7
42	R:R:L165	R:R:N170	6.87	No	No	0	9	9
43	R:R:E398	R:R:L165	6.63	No	No	0	9	9
44	R:R:H166	R:R:Y171	11.98	No	No	0	7	6
45	R:R:C167	R:R:N170	4.72	No	No	0	8	9
46	R:R:I172	R:R:T168	3.04	No	Yes	8	9	8
47	R:R:T168	R:R:Y240	8.74	Yes	Yes	8	8	8
48	R:R:F256	R:R:T168	5.19	No	Yes	0	5	8
49	R:R:H173	R:R:R169	15.8	No	No	0	9	9
50	R:R:N396	R:R:R169	12.05	No	No	7	9	9
51	R:R:E398	R:R:R169	4.65	No	No	7	9	9
52	R:R:F256	R:R:Y171	7.22	No	No	0	5	6
53	R:R:I172	R:R:Y240	6.04	No	Yes	8	9	8
54	R:R:H173	R:R:Y392	27.22	No	Yes	0	9	8
55	R:R:N175	R:R:W233	14.69	No	Yes	0	9	9
56	R:R:F256	R:R:N175	3.62	No	No	0	5	9
57	R:R:F180	R:R:L176	4.87	Yes	No	0	8	9
58	R:R:L176	R:R:Y392	4.69	No	Yes	0	9	8
59	R:R:F177	R:R:Y392	6.19	Yes	Yes	0	9	8
60	R:R:M181	R:R:T178	3.01	Yes	No	0	7	3
61	R:R:A229	R:R:S179	3.42	No	No	1	8	9
62	R:R:N230	R:R:S179	5.96	No	No	0	9	9
63	R:R:S179	R:R:W264	4.94	No	Yes	1	9	9
64	R:R:F180	R:R:N230	18.12	Yes	No	0	8	9
65	R:R:F180	R:R:Q384	5.86	Yes	No	6	8	9
66	R:R:F180	R:R:G385	3.01	Yes	No	6	8	9
67	R:R:F180	R:R:V388	5.24	Yes	No	0	8	9
68	R:R:C226	R:R:R183	5.57	No	Yes	0	6	8
69	R:R:R183	R:R:V227	3.92	Yes	No	0	8	6
70	R:R:N230	R:R:R183	12.05	No	Yes	0	9	8
71	R:R:E354	R:R:R183	5.82	No	Yes	0	7	8
72	R:R:Q384	R:R:R183	3.5	No	Yes	0	9	8
73	R:R:A186	R:R:V222	3.39	No	No	0	6	5
74	R:R:I187	R:R:R190	3.76	No	Yes	0	7	6
75	R:R:Q220	R:R:R190	10.51	No	Yes	0	5	6
76	R:R:R190	R:R:T223	6.47	Yes	No	0	6	6
77	R:R:D191	R:R:R192	4.76	No	No	0	7	4
78	R:R:L194	R:R:P195	4.93	No	No	0	7	3
79	R:R:L194	R:R:W287	3.42	No	No	0	7	9
80	R:R:A212	R:R:N210	3.13	No	No	0	6	4
81	R:R:C216	R:R:C286	7.28	No	No	0	9	9
82	R:R:R217	R:R:R278	11.73	No	No	0	8	8
83	R:R:N283	R:R:R217	3.62	No	No	0	6	8
84	R:R:Q220	R:R:Q224	3.84	No	No	0	5	6
85	R:R:Q220	R:R:W287	18.62	No	No	0	5	9
86	R:R:I221	R:R:W274	3.52	No	Yes	0	5	8
87	R:R:I221	R:R:V275	4.61	No	No	0	5	6
88	R:R:Q224	R:R:W274	6.57	No	Yes	0	6	8
89	R:R:W264	R:R:Y225	8.68	Yes	No	0	9	8
90	R:R:G228	R:R:P267	4.06	No	Yes	0	5	9
91	R:R:A229	R:R:W264	3.89	No	Yes	1	8	9
92	R:R:A229	R:R:P267	3.74	No	Yes	0	8	9
93	R:R:I303	R:R:Y231	7.25	No	No	0	7	8
94	R:R:V355	R:R:Y231	10.09	No	No	0	5	8
95	R:R:G263	R:R:T232	3.64	No	No	0	9	6
96	R:R:A266	R:R:T232	3.36	No	No	0	4	6
97	R:R:P267	R:R:T232	10.49	Yes	No	0	9	6
98	R:R:V236	R:R:W233	7.36	No	Yes	0	8	9
99	R:R:L260	R:R:W233	3.42	No	Yes	1	6	9
100	R:R:G263	R:R:W233	7.04	No	Yes	0	9	9
101	R:R:W233	R:R:W264	17.81	Yes	Yes	1	9	9
102	R:R:L234	R:R:P348	6.57	No	No	0	9	9
103	R:R:L235	R:R:N310	10.98	Yes	No	0	8	9
104	R:R:E237	R:R:G238	4.91	No	No	0	9	9
105	R:R:E237	R:R:Y392	7.86	No	Yes	0	9	8
106	R:R:F314	R:R:G238	3.01	No	No	0	9	9
107	R:R:L244	R:R:Y240	4.69	No	Yes	0	8	8
108	R:R:Y240	R:R:Y259	6.95	Yes	No	0	8	8
109	R:R:I317	R:R:L241	4.28	No	No	0	9	9
110	R:R:H242	R:R:V246	11.07	Yes	No	0	8	7
111	R:R:H242	R:R:R316	3.39	Yes	No	0	8	8
112	R:R:I320	R:R:L245	5.71	No	No	0	8	8
113	R:R:E252	R:R:H255	24.62	No	No	0	7	4
114	R:R:H255	R:R:Y258	6.53	No	No	0	4	3
115	R:R:L260	R:R:W264	3.42	No	Yes	1	6	9
116	R:R:G263	R:R:L262	3.42	No	No	0	9	6
117	R:R:F270	R:R:I299	8.79	No	No	0	5	7
118	R:R:F270	R:R:P302	28.9	No	No	0	5	9
119	R:R:I299	R:R:V271	3.07	No	No	0	7	6
120	R:R:I272	R:R:P273	5.08	No	No	0	2	4
121	R:R:R278	R:R:W274	6	No	Yes	0	8	8
122	R:R:I298	R:R:W274	4.7	No	Yes	0	8	8
123	R:R:I299	R:R:W274	7.05	No	Yes	0	7	8
124	R:R:R278	R:R:T284	3.88	No	No	0	8	4
125	R:R:N283	R:R:Y279	3.49	No	No	0	6	3
126	R:R:E282	R:R:Y281	4.49	No	No	0	5	3
127	R:R:E282	R:R:I295	4.1	No	Yes	0	5	3
128	R:R:C286	R:R:W287	5.22	No	No	0	9	9
129	R:R:E288	R:R:R289	3.49	No	No	0	6	4
130	R:R:N290	R:R:W296	11.3	No	No	0	6	6
131	R:R:E291	R:R:V292	5.7	No	No	0	4	6
132	R:R:I295	R:R:V292	6.14	Yes	No	0	3	6
133	R:R:W296	R:R:W297	6.56	No	No	0	6	7
134	R:R:R300	R:R:W296	12	Yes	No	0	7	6
135	R:R:T301	R:R:W297	3.64	No	No	0	4	7
136	R:R:I303	R:R:R300	3.76	No	Yes	0	7	7
137	R:R:R300	R:R:V355	9.15	Yes	No	0	7	5
138	R:R:P302	R:R:T301	3.5	No	No	0	9	4
139	R:R:M305	R:R:T301	3.01	No	No	0	4	4
140	R:R:I307	R:R:L349	9.99	No	Yes	0	7	9
141	R:R:I307	R:R:V352	6.14	No	No	0	7	6
142	R:R:F311	R:R:I315	8.79	No	No	0	6	5
143	R:R:F311	R:R:L349	3.65	No	Yes	0	6	9
144	R:R:F314	R:R:L346	8.53	No	No	0	9	9
145	R:R:I320	R:R:R316	3.76	No	No	0	8	8
146	R:R:L318	R:R:R338	3.64	Yes	No	0	7	9
147	R:R:L318	R:R:S342	4.5	Yes	No	0	7	9
148	R:R:L321	R:R:L325	4.15	No	No	0	9	7
149	R:R:L322	R:R:R338	8.5	No	No	0	5	9
150	R:R:D334	R:R:L325	9.5	No	No	0	6	7
151	R:R:R326	R:R:Y335	13.38	No	No	0	7	5
152	R:R:M330	R:R:R328	4.96	No	No	0	5	6
153	R:R:D334	R:R:M330	4.16	No	No	0	6	5
154	R:R:R331	R:R:R333	19.19	No	No	0	5	6
155	R:R:L337	R:R:R341	4.86	No	No	0	7	9
156	R:R:L339	R:R:S342	4.5	No	No	0	9	9
157	R:R:A340	R:R:R341	4.15	No	No	0	8	9
158	R:R:S342	R:R:T343	3.2	No	No	0	9	9
159	R:R:F345	R:R:L344	3.65	No	No	0	8	8
160	R:R:L344	R:R:L391	12.46	No	No	0	8	7
161	R:R:L346	R:R:L349	4.15	No	Yes	0	9	9
162	R:R:P348	R:R:V347	3.53	No	No	0	9	8
163	R:R:L387	R:R:V347	8.94	No	No	0	6	8
164	R:R:P348	R:R:V388	3.53	No	No	0	9	9
165	R:R:H353	R:R:L350	7.71	No	No	0	8	9
166	R:R:E354	R:R:S381	10.06	No	No	0	7	5
167	R:R:F357	R:R:K373	7.44	No	No	0	7	7
168	R:R:E377	R:R:F357	13.99	No	No	0	7	7
169	R:R:A358	R:R:P359	3.74	No	No	0	6	5
170	R:R:L374	R:R:V360	5.96	No	No	0	6	4
171	R:R:E362	R:R:T361	4.23	No	No	0	5	7
172	R:R:G375	R:R:I378	3.53	No	Yes	0	5	8
173	R:R:F376	R:R:L380	3.65	No	No	0	4	7
174	R:R:E377	R:R:I378	4.1	No	Yes	0	7	8
175	R:R:G385	R:R:Q384	4.93	No	No	6	9	9
176	R:R:F386	R:R:S389	3.96	Yes	No	5	5	8
177	R:R:F386	R:R:V390	5.24	Yes	No	0	5	5
178	R:R:L391	R:R:V390	5.96	No	No	0	7	5
179	R:R:F394	R:R:V390	6.55	No	No	0	8	5
180	R:R:E398	R:R:N396	13.15	No	No	7	9	9
181	R:R:H408	R:R:R404	5.64	No	No	0	4	6
182	R:R:H409	R:R:R405	18.05	No	No	0	7	8
183	R:R:H408	R:R:W407	7.41	No	No	0	4	5
184	R:R:R411	R:R:W407	18.99	No	No	0	4	5
185	R:R:L152	R:R:S389	3	Yes	No	0	9	8
186	R:R:G406	R:R:R405	3	No	No	0	5	8
187	R:R:L165	R:R:V399	2.98	No	No	0	9	9
188	R:R:L235	R:R:V239	2.98	Yes	No	0	8	7
189	R:R:C393	R:R:H173	2.95	No	No	0	9	9
190	R:R:L235	R:R:T306	2.95	Yes	No	0	8	7
191	R:R:I309	R:R:I313	2.94	No	No	0	6	8
192	R:R:I158	R:R:L159	2.85	No	No	0	8	8
193	R:R:I309	R:R:L235	2.85	No	Yes	0	6	8
194	R:R:I395	R:R:L391	2.85	No	No	0	5	7
195	R:R:I295	R:R:N290	2.83	Yes	No	0	3	6
196	R:R:I307	R:R:N310	2.83	No	No	0	7	9
197	R:R:E253	R:R:T168	2.82	No	Yes	0	5	8
198	R:R:E288	R:R:T284	2.82	No	No	0	6	4
199	R:R:A219	R:R:R190	2.77	No	Yes	0	6	6
200	R:R:A368	R:R:F371	2.77	No	No	0	1	4
201	R:R:L213	R:R:N210	2.75	No	No	0	4	4
202	R:R:A268	R:R:Y225	2.67	No	No	0	3	8
203	R:R:E237	R:R:L241	2.65	No	No	0	9	9
204	R:R:H242	R:R:I313	2.65	Yes	No	0	8	8
205	R:R:H242	R:R:I317	2.65	Yes	No	0	8	9
206	R:R:F379	R:R:S382	2.64	No	Yes	0	6	9
207	R:R:R300	R:R:V356	2.62	Yes	No	0	7	6
208	R:R:S382	R:R:Y145	2.54	Yes	Yes	0	9	7
209	R:R:S243	R:R:Y259	2.54	No	No	0	7	8
210	R:R:L304	R:R:R300	2.43	No	Yes	0	4	7
211	R:R:L322	R:R:R326	2.43	No	No	0	5	7
212	R:R:L344	R:R:R341	2.43	No	No	0	8	9
213	R:R:L280	R:R:Y279	2.34	No	No	0	3	3
214	R:R:K293	R:R:W297	2.32	No	No	0	5	7
215	R:R:L182	R:R:W264	2.28	No	Yes	0	7	9
216	R:R:H255	R:R:Y259	2.18	No	No	0	4	8
217	R:R:R333	R:R:R336	2.13	No	No	0	6	6
218	R:R:G249	R:R:G250	2.11	No	No	0	7	6
219	R:R:G265	R:R:P267	2.03	No	Yes	0	6	9
220	R:R:G250	R:R:S251	1.86	No	No	0	6	7
221	R:R:G144	R:R:V143	1.84	No	No	0	8	5
222	R:R:G249	R:R:V248	1.84	No	No	0	7	7
223	R:R:A186	R:R:C226	1.81	No	No	0	6	6
224	R:R:A184	R:R:S148	1.71	No	No	0	8	9
225	R:R:G319	R:R:L322	1.71	No	No	0	8	5
226	R:R:A294	R:R:V292	1.7	No	No	0	3	6
227	R:R:I298	R:R:P273	1.69	No	No	0	8	4
228	R:R:E252	R:R:G254	1.64	No	No	0	7	5
229	R:R:E354	R:R:G351	1.64	No	No	0	7	9
230	R:R:V139	R:R:V143	1.6	No	No	0	3	5
231	R:R:S323	R:R:T327	1.6	No	No	0	7	6
232	R:R:T218	R:R:V222	1.59	No	No	0	3	5
233	R:R:T361	R:R:V360	1.59	No	No	0	7	4
234	R:R:A184	R:R:L149	1.58	No	No	0	8	6
235	R:R:A215	R:R:L193	1.58	No	No	0	3	5
236	R:R:A372	R:R:L369	1.58	No	No	0	5	4
237	R:R:I276	R:R:V275	1.54	No	No	0	3	6
238	R:R:I295	R:R:V277	1.54	Yes	No	0	3	5
239	R:R:I298	R:R:V277	1.54	No	No	0	8	5
240	R:R:C286	R:R:Q285	1.53	No	No	0	9	3
241	R:R:L247	R:R:S243	1.5	No	No	0	5	7
242	R:R:G367	R:R:R366	1.5	No	No	0	4	5
243	R:R:G367	R:R:R370	1.5	No	No	0	4	5
244	R:R:I320	R:R:K324	1.45	No	No	0	8	9
245	R:R:I317	R:R:L318	1.43	No	Yes	0	9	7
246	R:R:Q400	R:R:V399	1.43	No	No	0	8	9
247	R:R:E363	R:R:T361	1.41	No	No	0	5	7
248	R:R:L318	R:R:L321	1.38	Yes	No	0	7	9
249	R:R:L325	R:R:L337	1.38	No	No	0	7	7
250	R:R:A340	R:R:R336	1.38	No	No	0	8	6
251	R:R:L349	R:R:L350	1.38	Yes	No	0	9	9
252	R:R:E125	R:R:L128	1.33	No	No	0	3	3
253	R:R:L213	R:R:Q285	1.33	No	No	0	4	3
254	R:R:F383	R:R:S382	1.32	No	Yes	0	6	9
255	R:R:D129	R:R:E125	1.3	No	No	0	1	3
256	R:R:F394	R:R:L154	1.22	No	No	0	8	5
257	R:R:F127	R:R:N124	1.21	No	No	0	2	1
258	R:R:L132	R:R:R131	1.21	No	Yes	0	3	3
259	R:R:L193	R:R:R192	1.21	No	No	0	5	4
260	R:R:E135	R:R:R136	1.16	No	No	0	3	4
261	R:R:H166	R:R:R163	1.13	No	No	0	7	8
262	R:R:R411	R:R:R414	1.07	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Q130	4.7125	4	2	3
2	R:R:R131	4.5075	4	2	3
3	R:R:Y141	9.4175	4	4	7
4	R:R:Y145	8.596	5	4	7
5	R:R:L152	4.784	5	0	9
6	R:R:T168	4.9475	4	8	8
7	R:R:F177	5.065	4	0	9
8	R:R:F180	7.40167	6	6	8
9	R:R:M181	4.9925	4	0	7
10	R:R:R183	6.172	5	0	8
11	R:R:R190	5.8775	4	0	6
12	R:R:W233	10.064	5	1	9
13	R:R:L235	4.94	4	0	8
14	R:R:Y240	6.605	4	8	8
15	R:R:H242	4.94	4	0	8
16	R:R:W264	6.83667	6	1	9
17	R:R:P267	5.08	4	0	9
18	R:R:W274	5.568	5	0	8
19	R:R:I295	3.6525	4	0	3
20	R:R:R300	5.992	5	0	7
21	R:R:L318	2.7375	4	0	7
22	R:R:L349	4.7925	4	0	9
23	R:R:I378	5.395	4	0	8
24	R:R:S382	2.5525	4	0	9
25	R:R:F386	8.8325	4	5	5
26	R:R:Y392	11.49	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q364	R:R:R131	17.3862	3.5	No	Yes	0	5	3
2	R:R:L134	R:R:Q364	18.6959	11.98	No	No	0	5	5
3	R:R:L134	R:R:L137	19.7577	6.92	No	No	3	5	6
4	R:R:I378	R:R:L137	28.0088	4.28	Yes	No	0	8	6
5	R:R:I378	R:R:Y141	34.5011	9.67	Yes	Yes	0	8	7
6	R:R:Y141	R:R:Y145	30.2212	19.86	Yes	Yes	4	7	7
7	R:R:S382	R:R:Y145	11.7452	2.54	Yes	Yes	0	9	7
8	R:R:S381	R:R:Y145	98.1103	5.09	No	Yes	0	5	7
9	R:R:E354	R:R:S381	98.7605	10.06	No	No	0	7	5
10	R:R:E354	R:R:R183	100	5.82	No	Yes	0	7	8
11	R:R:N230	R:R:R183	59.4134	12.05	No	Yes	0	9	8
12	R:R:F180	R:R:N230	58.4592	18.12	Yes	No	0	8	9
13	R:R:F180	R:R:L152	31.7648	7.31	Yes	Yes	0	8	9
14	R:R:L152	R:R:S389	22.8823	3	Yes	No	0	9	8
15	R:R:F386	R:R:S389	20.0992	3.96	Yes	No	5	5	8
16	R:R:Q384	R:R:R183	44.4923	3.5	No	Yes	0	9	8
17	R:R:F180	R:R:Q384	43.9918	5.86	Yes	No	6	8	9
18	R:R:F180	R:R:L176	66.6776	4.87	Yes	No	0	8	9
19	R:R:L176	R:R:Y392	65.7281	4.69	No	Yes	0	9	8
20	R:R:H173	R:R:Y392	26.5868	27.22	No	Yes	0	9	8
21	R:R:C393	R:R:H173	13.6302	2.95	No	No	0	9	9
22	R:R:C393	R:R:L159	12.1381	4.76	No	No	0	9	8
23	R:R:H173	R:R:R169	12.1989	15.8	No	No	0	9	9
24	R:R:N230	R:R:S179	30.3662	5.96	No	No	0	9	9
25	R:R:S179	R:R:W264	24.0376	4.94	No	Yes	1	9	9
26	R:R:W233	R:R:W264	20.2021	17.81	Yes	Yes	1	9	9
27	R:R:N175	R:R:W233	17.1336	14.69	No	Yes	0	9	9
28	R:R:F256	R:R:N175	16.1981	3.62	No	No	0	5	9
29	R:R:F256	R:R:T168	12.3626	5.19	No	Yes	0	5	8
30	R:R:I187	R:R:R190	66.6682	3.76	No	Yes	0	7	6
31	R:R:Q220	R:R:R190	63.5951	10.51	No	Yes	0	5	6
32	R:R:Q220	R:R:W287	13.1718	18.62	No	No	0	5	9
33	R:R:Q220	R:R:Q224	52.7433	3.84	No	No	0	5	6
34	R:R:Q224	R:R:W274	51.6067	6.57	No	Yes	0	6	8
35	R:R:R278	R:R:W274	11.7358	6	No	Yes	0	8	8
36	R:R:I298	R:R:W274	26.3764	4.7	No	Yes	0	8	8
37	R:R:I298	R:R:V277	22.4052	1.54	No	No	0	8	5
38	R:R:I295	R:R:V277	21.0814	1.54	Yes	No	0	3	5
39	R:R:I295	R:R:N290	12.9987	2.83	Yes	No	0	3	6
40	R:R:N290	R:R:W296	11.6282	11.3	No	No	0	6	6
41	R:R:R300	R:R:W296	10.2764	12	Yes	No	0	7	6
42	R:R:E237	R:R:Y392	51.7283	7.86	No	Yes	0	9	8
43	R:R:E237	R:R:L241	36.882	2.65	No	No	0	9	9
44	R:R:I317	R:R:L241	35.6565	4.28	No	No	0	9	9
45	R:R:H242	R:R:I317	16.4835	2.65	Yes	No	0	8	9
46	R:R:E237	R:R:G238	15.7304	4.91	No	No	0	9	9
47	R:R:F314	R:R:G238	14.2991	3.01	No	No	0	9	9
48	R:R:F314	R:R:L346	12.8678	8.53	No	No	0	9	9
49	R:R:L346	R:R:L349	11.4365	4.15	No	Yes	0	9	9
50	R:R:I299	R:R:W274	11.2306	7.05	No	Yes	0	7	8
51	R:R:I317	R:R:L318	21.4603	1.43	No	Yes	0	9	7
52	R:R:F386	R:R:V390	17.5546	5.24	Yes	No	0	5	5
53	R:R:L391	R:R:V390	13.822	5.96	No	No	0	7	5
54	R:R:L344	R:R:L391	11.4177	12.46	No	No	0	8	7
55	R:R:I187	R:R:Y145	60.8681	8.46	No	Yes	4	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8ITM_nogp

PDB Summary
PDB	8ITM_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.01
Number of Linked Nodes	256
Number of Links	262
Number of Hubs	26
Number of Links mediated by Hubs	104
Number of Communities	8
Number of Nodes involved in Communities	26
Number of Links involved in Communities	27

Path Summary
Number Of Nodes in MetaPath	56
Number Of Links MetaPath	55
Number of Shortest Paths	35485
Length Of Smallest Path	3
Average Path Length	14.9901
Length of Longest Path	30
Minimum Path Strength	1.315
Average Path Strength	6.83275
Maximum Path Strength	21.51
Minimum Path Correlation	0.7
Average Path Correlation	0.940943
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	51.8068
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.2354
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• peptide hormone receptor binding • protein binding • binding • corticotropin-releasing hormone receptor binding • signaling receptor binding • G protein-coupled receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • mu-type opioid receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • adrenergic receptor binding • D1 dopamine receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • ionotropic glutamate receptor binding • glutamate receptor binding • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • insulin-like growth factor receptor binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • intracellular anatomical structure • cytoplasm • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • gastric inhibitory peptide receptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • signaling • biological regulation • cellular process • signal transduction • cell communication • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P48546
Sequence	>8ITM_nogp_Chain_R N E A F L D Q R L I L E R L Q V M Y T V G Y S L S L A T L L L A L L I L S L F R R L H C T R N Y I H I N L F T S F M L R A A A I L S R D R L L P N Q A L A A C R T A Q I V T Q Y C V G A N Y T W L L V E G V Y L H S L L V L V G G S E E G H F R Y Y L L L G W G A P A L F V I P W V I V R Y L Y E N T Q C W E R N E V K A I W W I I R T P I L M T I L I N F L I F I R I L G I L L S K L R T R Q M R C R D Y R L R L A R S T L F L V P L L G V H E V V F A P V T E E Q A R G A L R F A K L G F E I F L S S F Q G F L V S V L Y C F I N K E V Q S E I R R G W H H C R L R R S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YW4	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ22	3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW4 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-		3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8WA3	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	2.86	2024-03-06	10.1038/s41421-024-00649-0
	8WA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		2.86	2024-03-06	10.1038/s41421-024-00649-0
	8ITM	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.13	2023-10-18	10.1073/pnas.2306145120
	8ITM (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.13	2023-10-18	10.1073/pnas.2306145120
	8ITL	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.23	2023-10-18	10.1073/pnas.2306145120
	8ITL (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.23	2023-10-18	10.1073/pnas.2306145120
	7RBT	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	PubChem 163183774	chim(NtGi1-Gs)/β1/γ2	3.08	2022-04-13	10.1073/pnas.2116506119
	7RBT (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	PubChem 163183774		3.08	2022-04-13	10.1073/pnas.2116506119
	7RA3	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	chim(NtGi1-Gs)/β1/γ2	3.24	2022-04-13	10.1073/pnas.2116506119
	7RA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		3.24	2022-04-13	10.1073/pnas.2116506119
	7VAB	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-03-02	10.1038/s41467-022-28683-0
	7VAB (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-		3.2	2022-03-02	10.1038/s41467-022-28683-0
	7FIY	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	10.1038/s41467-022-28683-0
	7FIY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	10.1038/s41467-022-28683-0
	7FIN	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-	Gs/β1/γ2	3.1	2022-02-23	10.1038/s41467-022-28683-0
	7FIN (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-		3.1	2022-02-23	10.1038/s41467-022-28683-0
	7DTY	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	Gs/β1/γ2	2.98	2021-08-04	10.7554/eLife.68719
	7DTY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		2.98	2021-08-04	10.7554/eLife.68719

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8ITM_nogp.zip

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