Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:Y141 6.1485157
2R:R:Y145 7.7885157
3R:R:T168 6.6325458
4R:R:R169 6.642559
5R:R:I172 4.8125459
6R:R:F177 4.5675409
7R:R:F180 8.66408
8R:R:R183 6.4225408
9R:R:R190 4.61754136
10R:R:W233 11.274559
11R:R:L235 2.8825408
12R:R:Y240 7.23458
13R:R:H242 6.695408
14R:R:Y259 3.865408
15R:R:W264 7.656559
16R:R:P267 3.444509
17R:R:W274 5.705888
18R:R:R278 8.288508
19R:R:E282 7.442585
20R:R:W287 5.9665139
21R:R:I295 5.7775483
22R:R:R300 6.6975407
23R:R:R341 3.3925409
24R:R:F345 4.434558
25R:R:V355 5.9325405
26R:R:F383 10.105406
27R:R:Y392 9.18558
28R:R:F394 5.17254168
29R:R:E398 5.1475459
30R:R:E402 9.09408
31R:R:H409 6.125407
32A:A:Y37 8.0225423
33A:A:K53 5.4754209
34A:A:F219 7.1285198
35A:A:H220 8.9925417
36A:A:M221 3.815408
37A:A:F222 9.28516
38A:A:Q227 5.175419
39A:A:E230 6.02419
40A:A:K233 6.77519
41A:A:W234 7.52419
42A:A:F246 4.3525109
43A:A:V247 4.105407
44A:A:Q267 5.22404
45A:A:F273 5.143336109
46A:A:W277 11.25254106
47A:A:W281 13.0925415
48A:A:L289 4.4454109
49A:A:F290 6.485229
50A:A:K293 4.56254219
51A:A:Q294 6.92436
52A:A:K307 6.3175405
53A:A:I308 4.442537
54A:A:F312 5.356538
55A:A:E314 4.694535
56A:A:F315 10.34536
57A:A:Y318 7.006537
58A:A:P321 4.8075434
59A:A:Y339 6.1275433
60A:A:F340 9.19167636
61A:A:R342 5.61635
62A:A:F345 7.84108
63A:A:Y360 10.436598
64A:A:F363 7.806535
65A:A:R373 4.784116
66A:A:R374 7.545404
67A:A:F376 4.48254119
68A:A:R385 5.618596
69A:A:H387 7.14178
70B:B:L4 5.5225404
71B:B:E12 8.0325404
72B:B:H54 9.12167629
73B:B:K57 9.84519
74B:B:Y59 10.486518
75B:B:W63 6.562507
76B:B:D76 6.642529
77B:B:K78 4.744528
78B:B:L79 3.744147
79B:B:W82 9.84143729
80B:B:D83 9.215428
81B:B:K89 6.89833629
82B:B:L95 4.9585148
83B:B:W99 9.728519
84B:B:M101 4.78419
85B:B:Y111 7.6854254
86B:B:C114 4.2154148
87B:B:E138 4.97406
88B:B:H142 8.295469
89B:B:Y145 6.58714718
90B:B:F151 4.382509
91B:B:I157 3.6875467
92B:B:T159 4.962569
93B:B:D163 7.02469
94B:B:W169 8.92833668
95B:B:Q176 7.538564
96B:B:F180 7.14577
97B:B:H183 8.08167679
98B:B:D186 5.5525419
99B:B:M188 6.635418
100B:B:F199 7.002579
101B:B:C204 4.93667617
102B:B:D205 8.1075479
103B:B:K209 11.5725476
104B:B:W211 10.166578
105B:B:Q220 6.21667647
106B:B:F222 7.5375448
107B:B:H225 8.48649
108B:B:I232 5.0975448
109B:B:F235 7.656126
110B:B:P236 5.66754127
111B:B:F241 6.726546
112B:B:T243 5.8425448
113B:B:D247 8.135449
114B:B:R251 10.35408
115B:B:F253 10.2525446
116B:B:D254 4.8175409
117B:B:R256 6.64409
118B:B:D258 7.092547
119B:B:Q259 4.2075406
120B:B:M262 5.435404
121B:B:Y264 6.328505
122B:B:C271 4.61415
123B:B:F278 5.5765127
124B:B:R283 7.8475409
125B:B:Y289 5.54714717
126B:B:D290 5.995416
127B:B:W297 6.7475418
128B:B:H311 8.8945269
129B:B:R314 13.194518
130B:B:T321 6.6854247
131B:B:V327 4.1975406
132B:B:W332 11.01619
133B:B:D333 9.34254269
134B:B:W339 7.3625409
135B:B:N340 4.6354239
136G:G:R27 5.98408
137G:G:Y40 8.80254126
138G:G:D48 5.504509
139G:G:F61 5.595238
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:E354 R:R:S381 13.6767.19NoNo075
2R:R:F180 R:R:L152 29.66854.87YesNo089
3R:R:F180 R:R:N230 60.398614.5YesNo089
4R:R:N230 R:R:R183 59.6238.44NoYes098
5R:R:R183 R:R:V355 58.06943.92YesYes085
6R:R:E354 R:R:V355 21.8585.7NoYes075
7R:R:F177 R:R:L152 30.47373.65YesNo099
8R:R:C393 R:R:F177 30.97235.59NoYes099
9R:R:C393 R:R:L159 31.8584.76NoNo098
10R:R:L159 R:R:N170 32.44344.12NoNo089
11R:R:F180 R:R:V388 32.31569.18YesNo089
12R:R:V388 R:R:Y392 32.50853.79NoYes098
13R:R:H173 R:R:Y392 36.98989.8NoYes598
14R:R:H173 R:R:R169 59.62995.64NoYes599
15R:R:E398 R:R:R169 60.52174.65YesYes599
16B:B:D312 B:B:D333 98.87676.65NoYes059
17B:B:D312 R:R:R164 96.46684.76NoNo057
18R:R:L165 R:R:R164 95.58546.07NoNo097
19R:R:L165 R:R:N170 32.68325.49NoNo099
20R:R:E398 R:R:L165 62.79813.98YesNo099
21R:R:E237 R:R:I172 24.61995.47NoYes599
22R:R:I172 R:R:Y240 20.20916.04YesYes598
23R:R:R300 R:R:V355 35.98276.54YesYes075
24R:R:R300 R:R:W296 32.374213.99YesNo076
25R:R:R289 R:R:W296 29.15295NoNo046
26R:R:R278 R:R:R289 17.66134.26YesNo084
27R:R:R278 R:R:W274 10.70195YesYes088
28R:R:Q224 R:R:W274 13.1869.86NoYes068
29R:R:Q220 R:R:Q224 12.36337.68NoNo056
30R:R:I299 R:R:R289 11.093.76NoNo074
31R:R:I299 R:R:W274 10.682511.74NoYes078
32R:R:L244 R:R:Y240 19.02524.69NoYes088
33A:A:H387 R:R:L244 18.815114.14YesNo088
34A:A:H387 A:A:I383 17.33935.3YesNo088
35G:G:D48 G:G:L50 11.66795.43YesNo099
36B:B:V327 G:G:L50 11.84754.47YesNo069
37B:B:M45 B:B:V327 99.98743.04NoYes046
38B:B:L308 B:B:M45 1009.9NoNo074
39B:B:L308 B:B:W339 99.73026.83NoYes079
40B:B:T329 B:B:W339 49.64099.7NoYes089
41B:B:H311 B:B:T329 49.59946.85YesNo098
42B:B:D333 B:B:H311 99.08147.56YesYes2699
43B:B:K337 B:B:W339 50.11359.28NoYes069
44B:B:H311 B:B:K337 49.65259.17YesNo096
45B:B:R314 B:B:W332 87.500432.99YesYes189
46B:B:R314 B:B:T274 81.56265.17YesNo188
47B:B:S275 B:B:T274 90.08544.8NoNo088
48B:B:L318 B:B:S275 90.1073NoNo068
49B:B:L318 B:B:S277 90.13093NoNo065
50B:B:S277 B:B:V320 90.15954.85NoNo057
51B:B:V320 B:B:V327 90.18984.81NoYes076
52B:B:W332 B:B:Y59 87.06098.68YesYes198
53A:A:F246 A:A:L272 54.35966.09YesNo099
54A:A:L272 A:A:R231 54.61398.5NoNo099
55A:A:R231 A:A:W234 54.74139NoYes099
56A:A:W234 B:B:Y145 51.53585.79YesYes198
57B:B:M101 B:B:Y145 86.77277.18YesYes198
58B:B:M101 B:B:Y59 86.82083.59YesYes198
59A:A:Q227 B:B:N119 17.85365.28YesNo099
60A:A:Q227 B:B:Y145 14.72035.64YesYes198
61A:A:K233 B:B:Y145 30.72173.58YesYes198
62A:A:K233 B:B:N230 30.83065.6YesNo099
63A:A:F246 A:A:V248 17.60323.93YesNo097
64A:A:F246 A:A:F273 18.74273.22YesYes1099
65A:A:F246 A:A:L289 17.76323.65YesYes1099
66A:A:F345 A:A:V248 17.14617.87YesNo087
67A:A:F273 A:A:F345 17.21887.5YesYes1098
68A:A:F345 A:A:L289 17.15366.09YesYes1089
69A:A:F363 A:A:Q294 14.877110.54YesYes356
70A:A:F363 A:A:Y339 10.41396.19YesYes353
71A:A:P321 A:A:Y339 12.38878.34YesYes343
72A:A:P321 A:A:Y318 13.36894.17YesYes347
73A:A:F340 A:A:Y318 27.673312.38YesYes367
74A:A:F312 A:A:F340 34.0236.43YesYes386
75A:A:F312 A:A:Q267 44.69413.51YesYes084
76A:A:L270 A:A:Q267 50.54983.99NoYes064
77A:A:F345 A:A:L270 51.03019.74YesNo086
78A:A:F363 A:A:R342 10.40977.48YesYes355
79A:A:D343 A:A:R342 12.38375.96NoYes335
80A:A:D343 A:A:Y318 12.87519.2NoYes337
81A:A:Q294 A:A:S250 11.91015.78YesNo067
82A:A:L297 A:A:S250 10.91877.51NoNo097
83B:B:L14 B:B:Q17 10.21253.99NoNo084
84B:B:Q17 G:G:A23 10.57441.52NoNo048
85B:B:I18 G:G:A23 10.9363.25NoNo078
86B:B:I18 B:B:R22 11.29745.01NoNo076
87B:B:D258 B:B:R22 12.722210.72YesNo076
88B:B:D258 B:B:F222 15.9515.97YesYes478
89B:B:F222 B:B:F253 18.39129.65YesYes486
90B:B:F253 B:B:T243 19.43089.08YesYes468
91B:B:H225 B:B:T243 26.25988.21YesYes498
92B:B:H225 B:B:S245 14.911111.16YesNo499
93B:B:S227 B:B:S245 15.08233.26NoNo469
94B:B:D246 B:B:S227 30.50662.94NoNo096
95B:B:D246 B:B:N230 30.66895.39NoNo099
96B:B:D247 B:B:H225 14.91946.3YesYes499
97B:B:D247 B:B:S227 15.26185.89YesNo496
98B:B:W297 B:B:Y264 11.02618.68YesYes085
99B:B:W297 B:B:Y289 11.3835.79YesYes187
100B:B:C271 B:B:Y289 13.46984.03YesYes157
101B:B:C271 B:B:D290 14.03244.67YesYes156
102B:B:H142 B:B:T159 10.14535.48YesYes699
103B:B:H142 B:B:S161 16.128115.34YesNo699
104B:B:D163 B:B:S161 16.25938.83YesNo699
105B:B:D163 B:B:G144 16.96693.35YesNo698
106B:B:G144 B:B:N119 17.32763.39NoNo089
107R:R:E237 R:R:H173 22.476111.08NoNo599
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8WA3
Class B1
SubFamily Peptide
Type Glucagon
SubType GIP
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 2.86
Date 2024-03-06
D.O.I. 10.1038/s41421-024-00649-0
Net Summary
Imin 3.04
Number of Linked Nodes 859
Number of Links 993
Number of Hubs 139
Number of Links mediated by Hubs 527
Number of Communities 27
Number of Nodes involved in Communities 203
Number of Links involved in Communities 277
Path Summary
Number Of Nodes in MetaPath 108
Number Of Links MetaPath 107
Number of Shortest Paths 1409652
Length Of Smallest Path 3
Average Path Length 36.0121
Length of Longest Path 69
Minimum Path Strength 1.125
Average Path Strength 6.82698
Maximum Path Strength 24.49
Minimum Path Correlation 0.7
Average Path Correlation 0.983165
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.7027
Average % Of Corr. Nodes 41.5592
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.977
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP48546
Sequence
>8WA3_Chain_R
LDQRLILER LQVMYTVGY SLSLATLLL ALLILSLFR RLHCTRNYI 
HINLFTSFM LRAAAILSR DRLLPNQAL AACRTAQIV TQYCVGANY 
TWLLVEGVY LHSLLVLVG GSEEGHFRY YLLLGWGAP ALFVIPWVI 
VRYLYENTQ CWERNEVKA IWWIIRTPI LMTILINFL IFIRILGIL 
LSKLRTRQM RCRDYRLRL ARSTLFLVP LLGVHEVVF APVTEEQAR 
GALRFAKLG FEIFLSSFQ GFLVSVLYC FINKEVQSE IRRGWHHCR 
LRRS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP04896
Sequence
>8WA3_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGAGESGK 
NTIVKQMSG IFETKFQVD KVNFHMFDV GAQRDERRK WIQCFNDVT 
AIIFVVASS QTNRLQAAL KLFDSIWNN KWLRDTSVI LFLNKQDLL 
AEKVLAGKS KIEDYFPEF ARYTTPEDA TPEPGEDPR VTRAKYFIR 
DEFLRISTA SGDGRHYCY PHFTCSVDT ENIRRVFND CRDIIQRMH 
LRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>8WA3_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>8WA3_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7DTYB1PeptideGlucagonGIPHomo sapiensGIP-Gs/&β;1/&γ;22.982021-08-0410.7554/eLife.68719
7FINB1PeptideGlucagonGIPHomo sapiensPeptide-20; GGL-Gs/&β;1/&γ;23.12022-02-2310.1038/s41467-022-28683-0
7FIYB1PeptideGlucagonGIPHomo sapiensTirzepatide-Gs/&β;1/&γ;23.42022-03-0210.1038/s41467-022-28683-0
7RA3B1PeptideGlucagonGIPHomo sapiensGIP-chim(NtGi1-Gs)/&β;1/&γ;23.242022-04-1310.1073/pnas.2116506119
7RBTB1PeptideGlucagonGIPHomo sapiensTirzepatidePubChem 163183774chim(NtGi1-Gs)/&β;1/&γ;23.082022-04-1310.1073/pnas.2116506119
7VABB1PeptideGlucagonGIPHomo sapiensNon-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;23.22022-03-0210.1038/s41467-022-28683-0
8ITLB1PeptideGlucagonGIPHomo sapiens--Gs/&β;1/&γ;23.232023-10-1810.1073/pnas.2306145120
8ITMB1PeptideGlucagonGIPHomo sapiens--Gs/&β;1/&γ;23.132023-10-1810.1073/pnas.2306145120
8WA3B1PeptideGlucagonGIPHomo sapiens--Gs/&β;1/&γ;22.862024-03-0610.1038/s41421-024-00649-0




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