psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E34	R:R:T31	7.06	No	No	0	5	5
2	R:R:R289	R:R:T31	3.88	No	No	0	4	5
3	R:R:G33	R:R:Y36	2.9	No	No	0	5	3
4	L:L:F22	R:R:L35	9.74	Yes	No	0	0	5
5	R:R:E40	R:R:W39	6.54	No	No	0	3	6
6	L:L:F22	R:R:W39	4.01	Yes	No	0	0	6
7	R:R:E48	R:R:R44	4.65	No	No	0	3	5
8	R:R:F127	R:R:Q130	4.68	No	No	0	2	3
9	L:L:K16	R:R:F127	9.93	No	No	0	0	2
10	R:R:F371	R:R:Q130	5.86	No	No	0	4	3
11	R:R:L132	R:R:R136	8.5	No	No	0	3	4
12	R:R:I133	R:R:L137	2.85	No	No	0	4	6
13	R:R:F371	R:R:I133	6.28	No	No	0	4	4
14	L:L:F6	R:R:L134	6.09	Yes	No	0	0	5
15	L:L:Y10	R:R:L134	5.86	No	No	0	0	5
16	R:R:E135	R:R:Q138	3.82	No	Yes	1	3	5
17	L:L:Y10	R:R:E135	3.37	No	No	1	0	3
18	R:R:L137	R:R:L374	2.77	No	No	1	6	6
19	L:L:F6	R:R:L137	3.65	Yes	No	1	0	6
20	R:R:Q138	R:R:Y141	4.51	Yes	Yes	1	5	7
21	R:R:D191	R:R:Q138	7.83	No	Yes	0	7	5
22	L:L:Y10	R:R:Q138	4.51	No	Yes	1	0	5
23	R:R:F379	R:R:M140	7.46	No	No	0	6	6
24	R:R:Y141	R:R:Y145	4.96	Yes	Yes	1	7	7
25	R:R:I378	R:R:Y141	3.63	Yes	Yes	1	8	7
26	L:L:F6	R:R:Y141	7.22	Yes	Yes	1	0	7
27	R:R:F383	R:R:G144	6.02	No	No	0	6	8
28	R:R:R183	R:R:Y145	8.23	Yes	Yes	1	8	7
29	R:R:I187	R:R:Y145	8.46	No	Yes	1	7	7
30	R:R:L188	R:R:Y145	3.52	No	Yes	0	7	7
31	R:R:S382	R:R:Y145	10.17	No	Yes	0	9	7
32	L:L:E3	R:R:Y145	3.37	No	Yes	1	0	7
33	R:R:L147	R:R:T151	2.95	No	No	3	5	7
34	R:R:F386	R:R:L147	6.09	No	No	3	5	5
35	R:R:F386	R:R:T151	7.78	No	No	3	5	7
36	R:R:S389	R:R:T151	4.8	No	No	0	8	7
37	R:R:F177	R:R:L152	4.87	Yes	No	0	9	9
38	R:R:G385	R:R:L152	3.42	No	No	0	9	9
39	R:R:L152	R:R:S389	4.5	No	No	0	9	8
40	R:R:L153	R:R:M181	2.83	No	No	0	3	7
41	R:R:I158	R:R:L154	2.85	No	No	0	8	5
42	R:R:A155	R:R:F177	2.77	No	Yes	4	9	9
43	R:R:A155	R:R:S389	3.42	No	No	0	9	8
44	R:R:A155	R:R:C393	3.61	No	No	4	9	9
45	R:R:L156	R:R:S160	3	Yes	No	0	6	3
46	R:R:I174	R:R:L156	4.28	No	Yes	0	7	6
47	R:R:L156	R:R:T178	2.95	Yes	No	0	6	3
48	R:R:L156	R:R:M181	4.24	Yes	No	0	6	7
49	R:R:I158	R:R:I403	5.89	No	No	0	8	5
50	R:R:I174	R:R:L159	4.28	No	No	0	7	8
51	R:R:C393	R:R:L159	3.17	No	No	0	9	8
52	R:R:F162	R:R:L165	6.09	No	No	5	7	9
53	R:R:E402	R:R:F162	15.16	No	No	5	8	7
54	R:R:H166	R:R:R163	3.39	No	No	0	7	8
55	R:R:E402	R:R:R164	9.3	No	No	0	8	7
56	R:R:E398	R:R:L165	3.98	No	No	0	9	9
57	R:R:E402	R:R:L165	5.3	No	No	5	8	9
58	R:R:H166	R:R:Y171	11.98	No	No	0	7	6
59	R:R:C167	R:R:N170	4.72	No	No	0	8	9
60	R:R:T168	R:R:Y240	4.99	No	Yes	0	8	8
61	R:R:N170	R:R:R169	9.64	No	No	0	9	9
62	R:R:H173	R:R:R169	10.16	No	No	0	9	9
63	R:R:F256	R:R:Y171	6.19	No	No	0	5	6
64	R:R:E237	R:R:I172	2.73	Yes	No	0	9	9
65	R:R:I172	R:R:Y240	8.46	No	Yes	0	9	8
66	R:R:E237	R:R:H173	7.39	Yes	No	0	9	9
67	R:R:H173	R:R:Y392	4.36	No	Yes	0	9	8
68	R:R:N175	R:R:W233	13.56	No	Yes	0	9	9
69	R:R:L260	R:R:N175	4.12	No	No	0	6	9
70	R:R:F180	R:R:L176	6.09	Yes	No	0	8	9
71	R:R:L176	R:R:L234	4.15	No	No	0	9	9
72	R:R:E237	R:R:L176	3.98	Yes	No	0	9	9
73	R:R:F177	R:R:V388	2.62	Yes	No	0	9	9
74	R:R:C393	R:R:F177	2.79	No	Yes	4	9	9
75	R:R:N230	R:R:S179	2.98	Yes	No	0	9	9
76	R:R:F180	R:R:R183	6.41	Yes	Yes	1	8	8
77	R:R:F180	R:R:N230	21.75	Yes	Yes	1	8	9
78	R:R:F180	R:R:Q384	9.37	Yes	No	1	8	9
79	R:R:F180	R:R:G385	4.52	Yes	No	0	8	9
80	R:R:C226	R:R:L182	3.17	No	No	0	6	7
81	R:R:R183	R:R:V227	2.62	Yes	No	0	8	6
82	R:R:N230	R:R:R183	12.05	Yes	Yes	1	9	8
83	R:R:A186	R:R:T223	3.36	No	No	0	6	6
84	R:R:A186	R:R:C226	3.61	No	No	0	6	6
85	L:L:E3	R:R:I187	2.73	No	No	1	0	7
86	R:R:A219	R:R:R190	2.77	No	Yes	0	6	6
87	R:R:Q220	R:R:R190	3.5	No	Yes	0	5	6
88	L:L:T7	R:R:R190	11.64	No	Yes	0	0	6
89	R:R:D191	R:R:R192	3.57	No	No	0	7	4
90	R:R:L194	R:R:P195	4.93	No	No	0	7	3
91	R:R:E288	R:R:L194	3.98	Yes	No	0	6	7
92	R:R:C286	R:R:P195	3.77	No	No	0	9	3
93	L:L:A18	R:R:P197	3.74	No	No	0	0	4
94	R:R:L208	R:R:N210	5.49	No	No	0	4	4
95	R:R:L208	R:R:Q211	2.66	No	No	0	4	3
96	R:R:C216	R:R:C286	7.28	No	No	0	9	9
97	R:R:N283	R:R:R217	12.05	No	No	0	6	8
98	R:R:R217	R:R:W287	5	No	Yes	0	8	9
99	R:R:Q220	R:R:Q224	5.12	No	Yes	0	5	6
100	R:R:I221	R:R:V275	7.68	No	No	2	5	6
101	R:R:I221	R:R:W287	5.87	No	Yes	2	5	9
102	R:R:Q224	R:R:W274	5.48	Yes	Yes	2	6	8
103	R:R:I299	R:R:Q224	5.49	No	Yes	2	7	6
104	L:L:Y1	R:R:Q224	13.53	Yes	Yes	0	0	6
105	R:R:W264	R:R:Y225	7.72	No	No	0	9	8
106	R:R:P267	R:R:Y225	2.78	Yes	No	0	9	8
107	R:R:A268	R:R:Y225	2.67	No	No	0	3	8
108	L:L:Y1	R:R:V227	6.31	Yes	No	0	0	6
109	R:R:G228	R:R:P267	4.06	No	Yes	0	5	9
110	R:R:L234	R:R:N230	2.75	No	Yes	0	9	9
111	R:R:I303	R:R:Y231	7.25	No	No	0	7	8
112	R:R:I307	R:R:Y231	4.84	No	No	7	7	8
113	R:R:E354	R:R:Y231	11.22	No	No	7	7	8
114	R:R:G263	R:R:T232	3.64	No	No	0	9	6
115	R:R:P267	R:R:T232	12.24	Yes	No	0	9	6
116	R:R:V236	R:R:W233	6.13	No	Yes	0	8	9
117	R:R:G263	R:R:W233	4.22	No	Yes	0	9	9
118	R:R:W233	R:R:W264	12.18	Yes	No	0	9	9
119	R:R:L235	R:R:V239	2.98	Yes	No	0	8	7
120	R:R:L235	R:R:T306	7.37	Yes	No	0	8	7
121	R:R:I309	R:R:L235	2.85	No	Yes	0	6	8
122	R:R:L235	R:R:N310	9.61	Yes	No	0	8	9
123	R:R:V236	R:R:Y259	3.79	No	Yes	0	8	8
124	R:R:E237	R:R:L349	11.93	Yes	No	0	9	9
125	R:R:L244	R:R:Y240	11.72	No	Yes	6	8	8
126	R:R:E252	R:R:Y240	7.86	No	Yes	6	7	8
127	R:R:Y240	R:R:Y259	3.97	Yes	Yes	0	8	8
128	R:R:L241	R:R:L245	4.15	No	No	8	9	8
129	R:R:I317	R:R:L241	2.85	Yes	No	8	9	9
130	R:R:H242	R:R:V246	12.45	No	No	0	8	7
131	R:R:H242	R:R:I313	7.95	No	No	0	8	8
132	R:R:L247	R:R:S243	4.5	No	No	0	5	7
133	R:R:E252	R:R:L244	6.63	No	No	6	7	8
134	R:R:I317	R:R:L245	4.28	Yes	No	8	9	8
135	R:R:I320	R:R:L245	2.85	No	No	0	8	8
136	R:R:E253	R:R:S251	7.19	No	No	0	5	7
137	R:R:H255	R:R:Y258	3.27	No	No	0	4	3
138	R:R:H255	R:R:Y259	9.8	No	Yes	0	4	8
139	R:R:F256	R:R:L260	6.09	No	No	0	5	6
140	R:R:F270	R:R:P302	18.78	No	No	0	5	9
141	R:R:I272	R:R:P273	3.39	No	No	0	2	4
142	R:R:R278	R:R:W274	9	Yes	Yes	2	8	8
143	R:R:W274	R:R:W287	3.75	Yes	Yes	2	8	9
144	R:R:I298	R:R:W274	4.7	No	Yes	0	8	8
145	R:R:I299	R:R:W274	11.74	No	Yes	2	7	8
146	R:R:V275	R:R:W287	4.9	No	Yes	2	6	9
147	R:R:I276	R:R:L280	2.85	No	No	0	3	3
148	R:R:V277	R:R:Y281	5.05	No	No	0	5	3
149	R:R:I295	R:R:V277	6.14	Yes	No	0	3	5
150	R:R:E282	R:R:R278	8.14	Yes	Yes	2	5	8
151	R:R:R278	R:R:T284	5.17	Yes	No	2	8	4
152	R:R:R278	R:R:W287	23.99	Yes	Yes	2	8	9
153	R:R:I295	R:R:R278	3.76	Yes	Yes	2	3	8
154	R:R:L280	R:R:Y279	3.52	No	No	0	3	3
155	R:R:E282	R:R:T284	2.82	Yes	No	2	5	4
156	R:R:E282	R:R:E291	6.34	Yes	No	0	5	4
157	R:R:E282	R:R:V292	7.13	Yes	No	2	5	6
158	R:R:E282	R:R:I295	4.1	Yes	Yes	2	5	3
159	R:R:C286	R:R:E288	4.56	No	Yes	0	9	6
160	L:L:T7	R:R:E288	5.64	No	Yes	0	0	6
161	L:L:S11	R:R:E288	10.06	No	Yes	0	0	6
162	L:L:S11	R:R:R289	3.95	No	No	0	0	4
163	L:L:D15	R:R:R289	7.15	No	No	0	0	4
164	R:R:N290	R:R:W296	13.56	No	No	0	6	6
165	L:L:S8	R:R:N290	8.94	No	No	0	0	6
166	R:R:I295	R:R:V292	6.14	Yes	No	2	3	6
167	R:R:R300	R:R:W296	7	No	No	0	7	6
168	L:L:Y1	R:R:W296	4.82	Yes	No	0	0	6
169	R:R:L304	R:R:R300	13.36	No	No	0	4	7
170	R:R:P302	R:R:T301	3.5	No	No	0	9	4
171	L:L:Y1	R:R:I303	3.63	Yes	No	0	0	7
172	R:R:E354	R:R:I307	8.2	No	No	7	7	7
173	R:R:F311	R:R:I315	6.28	No	No	0	6	5
174	R:R:F311	R:R:V355	9.18	No	No	0	6	5
175	R:R:I313	R:R:I317	2.94	No	Yes	0	8	9
176	R:R:F314	R:R:L318	6.09	Yes	No	0	9	7
177	R:R:F314	R:R:L346	4.87	Yes	No	0	9	9
178	R:R:F314	R:R:V347	2.62	Yes	No	9	9	8
179	R:R:F314	R:R:V352	11.8	Yes	No	9	9	6
180	R:R:I317	R:R:L321	2.85	Yes	No	0	9	9
181	R:R:I317	R:R:L346	4.28	Yes	No	0	9	9
182	R:R:L318	R:R:T343	2.95	No	No	0	7	9
183	R:R:I320	R:R:K324	2.91	No	No	0	8	9
184	R:R:L322	R:R:R326	3.64	No	No	10	5	7
185	R:R:L322	R:R:Y335	3.52	No	Yes	10	5	5
186	R:R:L325	R:R:R328	3.64	Yes	No	0	7	6
187	R:R:R326	R:R:Y335	5.14	No	Yes	10	7	5
188	R:R:D334	R:R:R328	3.57	No	No	0	6	6
189	R:R:R338	R:R:R341	6.4	No	No	0	9	9
190	R:R:F345	R:R:R341	12.83	No	No	0	8	9
191	R:R:L346	R:R:L350	4.15	No	No	0	9	9
192	R:R:P348	R:R:V347	3.53	No	No	0	9	8
193	R:R:V347	R:R:V352	9.62	No	No	9	8	6
194	R:R:L387	R:R:P348	3.28	No	No	0	6	9
195	R:R:L349	R:R:Y392	17.58	No	Yes	0	9	8
196	R:R:G351	R:R:H353	3.18	No	Yes	0	9	8
197	R:R:H353	R:R:L380	7.71	Yes	No	0	8	7
198	R:R:H353	R:R:S381	5.58	Yes	No	1	8	5
199	R:R:H353	R:R:Q384	6.18	Yes	No	1	8	9
200	R:R:F357	R:R:V356	3.93	Yes	No	0	7	6
201	R:R:F357	R:R:K373	6.2	Yes	No	0	7	7
202	R:R:F357	R:R:F376	9.65	Yes	No	0	7	4
203	R:R:R366	R:R:R370	3.2	No	No	0	5	5
204	R:R:E377	R:R:K373	9.45	No	No	0	7	7
205	R:R:I378	R:R:L374	4.28	Yes	No	1	8	6
206	L:L:F6	R:R:L374	6.09	Yes	No	1	0	6
207	R:R:F376	R:R:L380	6.09	No	No	0	4	7
208	L:L:?2	R:R:E377	6.34	Yes	No	0	0	7
209	L:L:?2	R:R:I378	2.73	Yes	Yes	0	0	8
210	L:L:F6	R:R:I378	5.02	Yes	Yes	1	0	8
211	R:R:F379	R:R:F383	6.43	No	No	0	6	6
212	R:R:Q384	R:R:S381	2.89	No	No	1	9	5
213	R:R:F386	R:R:V390	6.55	No	No	0	5	5
214	R:R:V388	R:R:Y392	3.79	No	Yes	0	9	8
215	R:R:F394	R:R:V390	3.93	No	No	0	8	5
216	R:R:I395	R:R:V390	3.07	No	No	0	5	5
217	R:R:N396	R:R:V399	5.91	No	No	0	9	9
218	R:R:H408	R:R:R404	4.51	Yes	No	0	4	6
219	R:R:H409	R:R:R405	4.51	No	No	0	7	8
220	R:R:H408	R:R:W407	9.52	Yes	No	0	4	5
221	L:L:G4	L:L:Y1	5.79	No	Yes	0	0	0
222	L:L:?2	L:L:E3	11.42	Yes	No	0	0	0
223	L:L:?2	L:L:T5	7.06	Yes	No	0	0	0
224	L:L:G4	L:L:T7	3.64	No	No	0	0	0
225	L:L:D9	L:L:T5	2.89	No	No	0	0	0
226	L:L:?13	L:L:I12	2.73	Yes	No	0	0	0
227	L:L:?13	L:L:L14	2.65	Yes	No	0	0	0
228	L:L:?13	L:L:K16	5.4	Yes	No	0	0	0
229	L:L:?13	L:L:I17	4.1	Yes	No	0	0	0
230	L:L:D15	L:L:Q19	6.53	No	No	0	0	0
231	L:L:F22	L:L:W25	3.01	Yes	No	0	0	0
232	L:L:F22	L:L:L26	9.74	Yes	No	0	0	0
233	R:R:R190	R:R:T223	2.59	Yes	No	0	6	6
234	R:R:S148	R:R:Y145	2.54	No	Yes	0	9	7
235	R:R:S243	R:R:Y259	2.54	No	Yes	0	7	8
236	L:L:I17	R:R:R131	2.51	No	No	0	0	3
237	R:R:I315	R:R:R316	2.51	No	No	0	5	8
238	R:R:F394	R:R:L154	2.44	No	No	0	8	5
239	R:R:L325	R:R:R338	2.43	Yes	No	0	7	9
240	R:R:N396	R:R:R169	2.41	No	No	0	9	9
241	R:R:L280	R:R:Y281	2.34	No	No	0	3	3
242	R:R:L325	R:R:Y335	2.34	Yes	Yes	0	7	5
243	R:R:L391	R:R:Y392	2.34	No	Yes	0	7	8
244	R:R:H242	R:R:R316	2.26	No	No	0	8	8
245	R:R:H408	R:R:R405	2.26	Yes	No	0	4	8
246	R:R:H408	R:R:R411	2.26	Yes	No	0	4	4
247	R:R:G249	R:R:G250	2.11	No	No	0	7	6
248	R:R:R257	R:R:Y258	2.06	No	No	0	3	3
249	R:R:A32	R:R:G33	1.95	No	No	0	4	5
250	R:R:A229	R:R:P267	1.87	No	Yes	0	8	9
251	R:R:A266	R:R:P267	1.87	No	Yes	0	4	9
252	R:R:A358	R:R:P359	1.87	No	No	0	6	5
253	R:R:G144	R:R:S382	1.86	No	No	0	8	9
254	R:R:G33	R:R:T31	1.82	No	No	0	5	5
255	R:R:P348	R:R:V388	1.77	No	No	0	9	9
256	R:R:A184	R:R:S148	1.71	No	No	0	8	9
257	R:R:C226	R:R:V222	1.71	No	No	0	6	5
258	R:R:G238	R:R:L350	1.71	No	No	0	9	9
259	R:R:G263	R:R:L262	1.71	No	No	0	9	6
260	R:R:G238	R:R:N310	1.7	No	No	0	9	9
261	R:R:A294	R:R:V292	1.7	No	No	0	3	6
262	L:L:L14	R:R:P197	1.64	No	No	0	0	4
263	R:R:E253	R:R:G254	1.64	No	No	0	5	5
264	R:R:V139	R:R:V143	1.6	No	No	0	3	5
265	R:R:S146	R:R:T142	1.6	No	No	0	7	7
266	R:R:V271	R:R:V275	1.6	No	No	0	6	6
267	R:R:T218	R:R:V222	1.59	No	No	0	3	5
268	R:R:A184	R:R:L149	1.58	No	No	0	8	6
269	R:R:A215	R:R:L193	1.58	No	No	0	3	5
270	L:L:I27	L:L:V23	1.54	No	No	0	0	0
271	R:R:L321	R:R:S342	1.5	No	No	0	9	9
272	R:R:I272	R:R:I276	1.47	No	No	0	2	3
273	R:R:I309	R:R:M305	1.46	No	No	0	6	4
274	R:R:D191	R:R:T142	1.45	No	No	0	7	7
275	L:L:I17	L:L:K20	1.45	No	No	0	0	0
276	R:R:P197	R:R:R196	1.44	No	No	0	4	3
277	R:R:E135	R:R:V139	1.43	No	No	0	3	3
278	R:R:I315	R:R:L312	1.43	No	No	0	5	4
279	R:R:E398	R:R:V399	1.43	No	No	0	9	9
280	R:R:L318	R:R:L339	1.38	No	Yes	0	7	9
281	R:R:L321	R:R:L339	1.38	No	Yes	0	9	9
282	R:R:L322	R:R:L339	1.38	No	Yes	0	5	9
283	R:R:L325	R:R:L339	1.38	Yes	Yes	0	7	9
284	R:R:E363	R:R:K293	1.35	No	No	0	5	5
285	L:L:Q19	R:R:L35	1.33	No	No	0	0	5
286	R:R:L213	R:R:Q285	1.33	No	No	0	4	3
287	R:R:F357	R:R:V360	1.31	Yes	No	0	7	4
288	R:R:E252	R:R:E253	1.27	No	No	0	7	5
289	R:R:K397	R:R:R341	1.24	No	No	0	5	9
290	R:R:T301	R:R:W297	1.21	No	No	0	4	7
291	R:R:E40	R:R:R43	1.16	No	No	0	3	4
292	R:R:E363	R:R:R366	1.16	No	No	0	5	5
293	R:R:R336	R:R:Y335	1.03	No	Yes	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Q138	5.1675	4	1	5
2	R:R:Y141	5.08	4	1	7
3	R:R:Y145	5.89286	7	1	7
4	R:R:L156	3.6175	4	0	6
5	R:R:F177	3.2625	4	4	9
6	R:R:F180	9.628	5	1	8
7	R:R:R183	7.3275	4	1	8
8	R:R:R190	5.125	4	0	6
9	R:R:Q224	7.405	4	2	6
10	R:R:N230	9.8825	4	1	9
11	R:R:W233	9.0225	4	0	9
12	R:R:L235	5.7025	4	0	8
13	R:R:E237	6.5075	4	0	9
14	R:R:Y240	7.4	5	6	8
15	R:R:Y259	5.025	4	0	8
16	R:R:P267	4.564	5	0	9
17	R:R:W274	6.934	5	2	8
18	R:R:R278	10.012	5	2	8
19	R:R:E282	5.706	5	2	5
20	R:R:W287	8.702	5	2	9
21	R:R:E288	6.06	4	0	6
22	R:R:I295	5.035	4	2	3
23	R:R:F314	6.345	4	9	9
24	R:R:I317	3.44	5	8	9
25	R:R:L325	2.4475	4	0	7
26	R:R:Y335	3.0075	4	10	5
27	R:R:L339	1.38	4	0	9
28	R:R:H353	5.6625	4	1	8
29	R:R:F357	5.2725	4	0	7
30	R:R:I378	3.915	4	1	8
31	R:R:Y392	7.0175	4	0	8
32	R:R:H408	4.6375	4	0	4
33	L:L:Y1	6.816	5	0	0
34	L:L:?2	6.8875	4	0	0
35	L:L:F6	5.614	5	1	0
36	L:L:?13	3.72	4	0	0
37	L:L:F22	6.625	4	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Q19	R:R:L35	11.5811	1.33	No	No	0	0	5
2	L:L:D15	L:L:Q19	13.1955	6.53	No	No	0	0	0
3	L:L:D15	R:R:R289	14.7921	7.15	No	No	0	0	4
4	L:L:S11	R:R:R289	24.0558	3.95	No	No	0	0	4
5	L:L:S11	R:R:E288	25.5689	10.06	No	Yes	0	0	6
6	L:L:T7	R:R:E288	34.3977	5.64	No	Yes	0	0	6
7	L:L:G4	L:L:T7	40.6172	3.64	No	No	0	0	0
8	L:L:G4	L:L:Y1	41.7789	5.79	No	Yes	0	0	0
9	L:L:Y1	R:R:V227	87.0845	6.31	Yes	No	0	0	6
10	R:R:R183	R:R:V227	87.7517	2.62	Yes	No	0	8	6
11	R:R:R183	R:R:Y145	60.89	8.23	Yes	Yes	1	8	7
12	R:R:Y141	R:R:Y145	40.0453	4.96	Yes	Yes	1	7	7
13	L:L:F6	R:R:Y141	24.9017	7.22	Yes	Yes	1	0	7
14	L:L:F6	R:R:L137	22.3877	3.65	Yes	No	1	0	6
15	R:R:I133	R:R:L137	22.0541	2.85	No	No	0	4	6
16	R:R:F371	R:R:I133	20.5469	6.28	No	No	0	4	4
17	R:R:F371	R:R:Q130	19.0278	5.86	No	No	0	4	3
18	R:R:F127	R:R:Q130	17.4967	4.68	No	No	0	2	3
19	L:L:K16	R:R:F127	15.9538	9.93	No	No	0	0	2
20	R:R:Q138	R:R:Y141	13.5053	4.51	Yes	Yes	1	5	7
21	R:R:F180	R:R:R183	100	6.41	Yes	Yes	1	8	8
22	R:R:F180	R:R:G385	61.7717	4.52	Yes	No	0	8	9
23	R:R:G385	R:R:L152	61.0628	3.42	No	No	0	9	9
24	R:R:L152	R:R:S389	15.3402	4.5	No	No	0	9	8
25	R:R:S389	R:R:T151	16.9129	4.8	No	No	0	8	7
26	R:R:F386	R:R:T151	13.1776	7.78	No	No	3	5	7
27	R:R:F177	R:R:L152	52.5855	4.87	Yes	No	0	9	9
28	R:R:C393	R:R:F177	13.3683	2.79	No	Yes	4	9	9
29	R:R:C393	R:R:L159	12.2126	3.17	No	No	0	9	8
30	R:R:I174	R:R:L159	10.5028	4.28	No	No	0	7	8
31	R:R:F386	R:R:V390	11.3547	6.55	No	No	0	5	5
32	R:R:F180	R:R:L176	47.7243	6.09	Yes	No	0	8	9
33	R:R:E237	R:R:L176	48.9694	3.98	Yes	No	0	9	9
34	R:R:E237	R:R:H173	27.4038	7.39	Yes	No	0	9	9
35	R:R:H173	R:R:R169	15.7631	10.16	No	No	0	9	9
36	R:R:N396	R:R:R169	11.1522	2.41	No	No	0	9	9
37	R:R:E237	R:R:I172	61.7598	2.73	Yes	No	0	9	9
38	R:R:I172	R:R:Y240	60.2407	8.46	No	Yes	0	9	8
39	R:R:Y240	R:R:Y259	49.3507	3.97	Yes	Yes	0	8	8
40	R:R:V236	R:R:Y259	39.5746	3.79	No	Yes	0	8	8
41	R:R:V236	R:R:W233	37.9006	6.13	No	Yes	0	8	9
42	R:R:N175	R:R:W233	11.3607	13.56	No	Yes	0	9	9
43	R:R:H173	R:R:Y392	20.8686	4.36	No	Yes	0	9	8
44	R:R:E237	R:R:L349	16.621	11.93	Yes	No	0	9	9
45	R:R:L349	R:R:Y392	16.0253	17.58	No	Yes	0	9	8
46	R:R:F177	R:R:V388	55.731	2.62	Yes	No	0	9	9
47	R:R:F180	R:R:Q384	13.3206	9.37	Yes	No	1	8	9
48	R:R:A186	R:R:C226	10.8364	3.61	No	No	0	6	6
49	R:R:A186	R:R:T223	13.5172	3.36	No	No	0	6	6
50	R:R:R190	R:R:T223	16.1861	2.59	Yes	No	0	6	6
51	L:L:T7	R:R:R190	14.3751	11.64	No	Yes	0	0	6
52	R:R:Q220	R:R:R190	14.5181	3.5	No	Yes	0	5	6
53	L:L:?13	L:L:K16	14.4585	5.4	Yes	No	0	0	0
54	R:R:Q220	R:R:Q224	15.6797	5.12	No	Yes	0	5	6
55	R:R:Q224	R:R:W274	36.7389	5.48	Yes	Yes	2	6	8
56	L:L:Y1	R:R:Q224	45.4188	13.53	Yes	Yes	0	0	6
57	R:R:W233	R:R:W264	12.9632	12.18	Yes	No	0	9	9
58	R:R:W264	R:R:Y225	11.1402	7.72	No	No	0	9	8
59	R:R:G263	R:R:W233	12.9632	4.22	No	Yes	0	9	9
60	R:R:P348	R:R:V388	73.746	1.77	No	No	0	9	9
61	R:R:P348	R:R:V347	71.1367	3.53	No	No	0	9	8
62	R:R:F314	R:R:V347	68.2235	2.62	Yes	No	9	9	8
63	R:R:F314	R:R:L346	39.39	4.87	Yes	No	0	9	9
64	R:R:L346	R:R:L350	15.0066	4.15	No	No	0	9	9
65	R:R:G238	R:R:L350	13.1717	1.71	No	No	0	9	9
66	R:R:G238	R:R:N310	11.3249	1.7	No	No	0	9	9
67	R:R:I317	R:R:L346	25.6404	4.28	Yes	No	0	9	9
68	R:R:I313	R:R:I317	14.4346	2.94	No	Yes	0	8	9
69	R:R:H242	R:R:I313	12.6713	7.95	No	No	0	8	8
70	R:R:R278	R:R:W274	24.7766	9	Yes	Yes	2	8	8
71	R:R:I295	R:R:R278	15.9478	3.76	Yes	Yes	2	3	8
72	R:R:I295	R:R:V277	11.4202	6.14	Yes	No	0	3	5
73	R:R:F314	R:R:L318	29.7152	6.09	Yes	No	0	9	7
74	R:R:L318	R:R:L339	26.6055	1.38	No	Yes	0	7	9
75	R:R:L325	R:R:L339	16.2755	1.38	Yes	Yes	0	7	9
76	R:R:H353	R:R:Q384	10.342	6.18	Yes	No	1	8	9
77	R:R:V388	R:R:Y392	33.3075	3.79	No	Yes	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:R289	R:R:T31	3.88	0	No	No	4	5	1	2
L:L:F22	R:R:L35	9.74	0	Yes	No	0	5	0	1
R:R:E40	R:R:W39	6.54	0	No	No	3	6	2	1
L:L:F22	R:R:W39	4.01	0	Yes	No	0	6	0	1
R:R:F127	R:R:Q130	4.68	0	No	No	2	3	1	2
L:L:K16	R:R:F127	9.93	0	No	No	0	2	0	1
R:R:I133	R:R:L137	2.85	0	No	No	4	6	2	1
L:L:F6	R:R:L134	6.09	1	Yes	No	0	5	0	1
L:L:Y10	R:R:L134	5.86	1	No	No	0	5	0	1
R:R:E135	R:R:Q138	3.82	1	No	Yes	3	5	1	1
L:L:Y10	R:R:E135	3.37	1	No	No	0	3	0	1
R:R:L137	R:R:L374	2.77	1	No	No	6	6	1	1
L:L:F6	R:R:L137	3.65	1	Yes	No	0	6	0	1
R:R:Q138	R:R:Y141	4.51	1	Yes	Yes	5	7	1	1
R:R:D191	R:R:Q138	7.83	0	No	Yes	7	5	2	1
L:L:Y10	R:R:Q138	4.51	1	No	Yes	0	5	0	1
R:R:Y141	R:R:Y145	4.96	1	Yes	Yes	7	7	1	1
R:R:I378	R:R:Y141	3.63	1	Yes	Yes	8	7	1	1
L:L:F6	R:R:Y141	7.22	1	Yes	Yes	0	7	0	1
R:R:R183	R:R:Y145	8.23	1	Yes	Yes	8	7	2	1
R:R:I187	R:R:Y145	8.46	1	No	Yes	7	7	1	1
R:R:L188	R:R:Y145	3.52	0	No	Yes	7	7	2	1
R:R:S382	R:R:Y145	10.17	0	No	Yes	9	7	2	1
L:L:E3	R:R:Y145	3.37	1	No	Yes	0	7	0	1
R:R:R183	R:R:V227	2.62	1	Yes	No	8	6	2	1
L:L:E3	R:R:I187	2.73	1	No	No	0	7	0	1
R:R:A219	R:R:R190	2.77	0	No	Yes	6	6	2	1
R:R:Q220	R:R:R190	3.5	0	No	Yes	5	6	2	1
L:L:T7	R:R:R190	11.64	0	No	Yes	0	6	0	1
R:R:E288	R:R:L194	3.98	0	Yes	No	6	7	1	2
L:L:A18	R:R:P197	3.74	0	No	No	0	4	0	1
R:R:Q220	R:R:Q224	5.12	0	No	Yes	5	6	2	1
R:R:Q224	R:R:W274	5.48	2	Yes	Yes	6	8	1	2
R:R:I299	R:R:Q224	5.49	2	No	Yes	7	6	2	1
L:L:Y1	R:R:Q224	13.53	0	Yes	Yes	0	6	0	1
L:L:Y1	R:R:V227	6.31	0	Yes	No	0	6	0	1
R:R:I303	R:R:Y231	7.25	0	No	No	7	8	1	2
R:R:I299	R:R:W274	11.74	2	No	Yes	7	8	2	2
R:R:C286	R:R:E288	4.56	0	No	Yes	9	6	2	1
L:L:T7	R:R:E288	5.64	0	No	Yes	0	6	0	1
L:L:S11	R:R:E288	10.06	0	No	Yes	0	6	0	1
L:L:S11	R:R:R289	3.95	0	No	No	0	4	0	1
L:L:D15	R:R:R289	7.15	0	No	No	0	4	0	1
R:R:N290	R:R:W296	13.56	0	No	No	6	6	1	1
L:L:S8	R:R:N290	8.94	0	No	No	0	6	0	1
R:R:R300	R:R:W296	7	0	No	No	7	6	2	1
L:L:Y1	R:R:W296	4.82	0	Yes	No	0	6	0	1
L:L:Y1	R:R:I303	3.63	0	Yes	No	0	7	0	1
R:R:E377	R:R:K373	9.45	0	No	No	7	7	1	2
R:R:I378	R:R:L374	4.28	1	Yes	No	8	6	1	1
L:L:F6	R:R:L374	6.09	1	Yes	No	0	6	0	1
L:L:?2	R:R:E377	6.34	0	Yes	No	0	7	0	1
L:L:?2	R:R:I378	2.73	0	Yes	Yes	0	8	0	1
L:L:F6	R:R:I378	5.02	1	Yes	Yes	0	8	0	1
R:R:R190	R:R:T223	2.59	0	Yes	No	6	6	1	2
R:R:S148	R:R:Y145	2.54	0	No	Yes	9	7	2	1
L:L:I17	R:R:R131	2.51	0	No	No	0	3	0	1
L:L:L14	R:R:P197	1.64	0	No	No	0	4	0	1
R:R:P197	R:R:R196	1.44	0	No	No	4	3	1	2
R:R:E135	R:R:V139	1.43	1	No	No	3	3	1	2
L:L:Q19	R:R:L35	1.33	0	No	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7VAB_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.62
Number of Linked Nodes	272
Number of Links	293
Number of Hubs	37
Number of Links mediated by Hubs	140
Number of Communities	10
Number of Nodes involved in Communities	52
Number of Links involved in Communities	63

Path Summary
Number Of Nodes in MetaPath	78
Number Of Links MetaPath	77
Number of Shortest Paths	37828
Length Of Smallest Path	3
Average Path Length	14.0208
Length of Longest Path	31
Minimum Path Strength	1.255
Average Path Strength	5.25101
Maximum Path Strength	16.065
Minimum Path Correlation	0.71
Average Path Correlation	0.948916
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	62.1164
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.4649
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• response to stimulus • response to stress • response to wounding • response to axon injury • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • response to metal ion • response to chemical • response to calcium ion • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • negative adaptation of signaling pathway • negative regulation of signaling • negative regulation of biological process • desensitization of G protein-coupled receptor signaling pathway • regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • regulation of response to stimulus • adaptation of signaling pathway • regulation of cell communication • metabolic process • generation of precursor metabolites and energy • response to hexose • response to monosaccharide • response to carbohydrate • response to glucose • response to oxygen-containing compound • gastric inhibitory peptide signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • developmental process • multicellular organism development • multicellular organismal process • pancreas development • endocrine system development • anatomical structure development • animal organ development • endocrine pancreas development • system development • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • cell surface receptor signaling pathway • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to lipid • response to fatty acid • response to nutrient levels • response to nutrient • positive regulation of cell communication • positive regulation of establishment of protein localization • positive regulation of insulin secretion • positive regulation of peptide hormone secretion • positive regulation of protein localization • positive regulation of biological process • positive regulation of secretion by cell • positive regulation of protein transport • positive regulation of hormone secretion • positive regulation of secretion • positive regulation of cellular process • positive regulation of peptide secretion • positive regulation of protein secretion • positive regulation of transport • positive regulation of signaling • cellular anatomical structure • membrane • cell periphery • plasma membrane • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • D1 dopamine receptor binding • molecular function activator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase activator activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to hormone • response to endogenous stimulus • response to peptide hormone • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • protein localization to cell cortex • response to ketone • response to prostaglandin • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to hormone stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • midbody • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • response to hypoxia • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • dendrite • dendritic tree • neuron projection • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • plasma membrane region • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	AIB
PDB Residues	L:L:?2 L:L:?13
Environment Details	Open EMBL-EBI Page
Code	AIB
Name	2-aminoisobutyric acid
Synonyms	α,α-dimethylglycine
Identifier
Formula	C4 H9 N O2
Molecular Weight	103.12
SMILES
PubChem	5245672
Formal Charge	0
Total Atoms	16
Total Chiral Atoms	0
Total Bonds	15
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P48546
Sequence	>7VAB_nogp_Chain_R Q T A G E L Y Q R W E R Y R R E C Q E F L D Q R L I L E R L Q V M Y T V G Y S L S L A T L L L A L L I L S L F R R L H C T R N Y I H I N L F T S F M L R A A A I L S R D R L L P R P L W N Q A L A A C R T A Q I V T Q Y C V G A N Y T W L L V E G V Y L H S L L V L V G G S E E G H F R Y Y L L L G W G A P A L F V I P W V I V R Y L Y E N T Q C W E R N E V K A I W W I I R T P I L M T I L I N F L I F I R I L G I L L S K L R T R Q D Y R L R L A R S T L F L V P L L G V H E V V F A P V E Q A R G A L R F A K L G F E I F L S S F Q G F L V S V L Y C F I N K E V Q S E I R R G W H H C R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YW4	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ22	3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW4 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-		3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8WA3	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	2.86	2024-03-06	10.1038/s41421-024-00649-0
	8WA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		2.86	2024-03-06	10.1038/s41421-024-00649-0
	8ITM	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.13	2023-10-18	10.1073/pnas.2306145120
	8ITM (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.13	2023-10-18	10.1073/pnas.2306145120
	8ITL	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.23	2023-10-18	10.1073/pnas.2306145120
	8ITL (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.23	2023-10-18	10.1073/pnas.2306145120
	7RBT	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	PubChem 163183774	chim(NtGi1-Gs)/β1/γ2	3.08	2022-04-13	10.1073/pnas.2116506119
	7RBT (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	PubChem 163183774		3.08	2022-04-13	10.1073/pnas.2116506119
	7RA3	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	chim(NtGi1-Gs)/β1/γ2	3.24	2022-04-13	10.1073/pnas.2116506119
	7RA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		3.24	2022-04-13	10.1073/pnas.2116506119
	7VAB	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-03-02	10.1038/s41467-022-28683-0
	7VAB (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-		3.2	2022-03-02	10.1038/s41467-022-28683-0
	7FIY	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	10.1038/s41467-022-28683-0
	7FIY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	10.1038/s41467-022-28683-0
	7FIN	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-	Gs/β1/γ2	3.1	2022-02-23	10.1038/s41467-022-28683-0
	7FIN (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-		3.1	2022-02-23	10.1038/s41467-022-28683-0
	7DTY	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	Gs/β1/γ2	2.98	2021-08-04	10.7554/eLife.68719
	7DTY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		2.98	2021-08-04	10.7554/eLife.68719

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Download 7VAB_nogp.zip

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