Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:H1 5.985610
2L:L:?2 4.775610
3L:L:Q3 3.67833610
4L:L:T5 4.132510
5L:L:F6 6.53510
6L:L:L14 7.12400
7L:L:F22 6.812520
8L:L:W25 4.0275420
9L:L:L26 6.1825420
10R:R:M29 4.5425
11R:R:W36 5.755626
12R:R:Y39 9.604526
13R:R:C43 5.47429
14R:R:R60 6.6525474
15R:R:Y65 6.4075426
16R:R:W68 9.558549
17R:R:P72 4.305401
18R:R:I79 6.22444
19R:R:W83 6.3775402
20R:R:Y84 7.53525
21R:R:P86 3.7975423
22R:R:W87 6.916523
23R:R:V91 5.095426
24R:R:K98 8.598548
25R:R:Q105 6.7075405
26R:R:W106 7.172509
27R:R:E127 5.945481
28R:R:M137 5.06404
29R:R:Q142 8.884515
30R:R:Y145 5.604517
31R:R:Y149 3.642518
32R:R:R173 7.8225439
33R:R:H177 4.7425439
34R:R:R199 13.8414
35R:R:Y202 8.855421
36R:R:W215 8.71422
37R:R:Q232 5.46417
38R:R:W241 6.98571759
39R:R:Y248 8.9675408
40R:R:Y267 6.86407
41R:R:W272 5.1975459
42R:R:P275 3.875609
43R:R:W282 4.905619
44R:R:K286 8.28418
45R:R:W295 10.14409
46R:R:F303 5.005414
47R:R:W304 6.76616
48R:R:R308 6.52667616
49R:R:F322 6.345439
50R:R:L347 2.72409
51R:R:I355 4.085408
52R:R:L357 6.815439
53R:R:L358 5.7325439
54R:R:H361 9.432568
55R:R:E362 8.31468
56R:R:F365 6.875417
57R:R:D370 5.6025414
58R:R:R378 4.03514
59R:R:L382 4.95415
60R:R:L386 4.7875417
61R:R:F391 3.816507
62R:R:L394 2.095405
63R:R:C401 3.195409
64L:L:?29 11.7613810
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:H1 R:R:Q232 25.31346.18YesYes107
2L:L:H1 R:R:W304 14.48263.17YesYes106
3L:L:?2 L:L:Q3 10.0752.55YesYes100
4L:L:Q3 R:R:Y145 39.85676.76YesYes107
5L:L:T5 R:R:R378 10.95682.59YesYes104
6L:L:F6 R:R:L382 12.93147.31YesYes105
7L:L:F6 R:R:F141 12.84643.22YesNo006
8R:R:Q142 R:R:Y145 65.18084.51YesYes157
9L:L:K10 R:R:Q142 61.662613.56NoYes105
10L:L:K10 L:L:L14 71.67084.23NoYes000
11R:R:Q232 R:R:W282 41.61583.29YesYes179
12R:R:K286 R:R:W282 47.37588.12YesYes189
13L:L:L14 R:R:Y202 72.426615.24YesYes001
14L:L:D15 R:R:Y202 38.57726.9NoYes001
15L:L:D15 R:R:M29 35.37935.54NoYes005
16R:R:L32 R:R:M29 13.31852.83NoYes245
17R:R:L32 R:R:P86 13.36253.28NoYes243
18R:R:P86 R:R:W87 10.77016.76YesYes233
19R:R:W215 R:R:Y202 35.974310.61YesYes221
20R:R:M29 R:R:W215 79.98974.65YesYes252
21L:L:F22 R:R:M29 1004.98YesYes205
22L:L:F22 L:L:L26 44.616510.96YesYes200
23L:L:F22 R:R:W36 51.91098.02YesYes206
24L:L:L26 R:R:Y84 44.7473.52YesYes205
25R:R:Y65 R:R:Y84 66.96573.97YesYes265
26R:R:W36 R:R:Y84 45.53777.72YesYes265
27R:R:Y39 R:R:Y84 23.777416.88YesYes265
28R:R:W83 R:R:Y39 14.09868.68YesYes026
29R:R:S66 R:R:Y65 63.66152.54NoYes056
30R:R:S66 R:R:W68 62.37594.94NoYes059
31R:R:W106 R:R:W68 36.05629.37YesYes099
32R:R:R60 R:R:W106 16.838210YesYes049
33R:R:T61 R:R:W106 11.3156.06NoYes069
34R:R:K98 R:R:W68 19.573213.92YesYes489
35R:R:D117 R:R:K98 14.09868.3NoYes478
36R:R:D117 R:R:P110 12.71593.22NoNo073
37R:R:G109 R:R:P110 11.3154.06NoNo043
38R:R:S390 R:R:Y149 16.13242.54NoYes098
39R:R:F391 R:R:S390 15.21116.61YesNo079
40R:R:F391 R:R:L394 11.43642.44YesYes075
41R:R:V279 R:R:W282 68.34532.45NoYes069
42R:R:V236 R:R:V279 67.92344.81NoNo066
43R:R:P275 R:R:V236 65.76815.3YesNo096
44R:R:P275 R:R:Y233 58.36142.78YesNo099
45R:R:W272 R:R:Y233 57.87273.86YesNo099
46R:R:W241 R:R:W272 56.118112.18YesYes599
47R:R:I176 R:R:W241 50.63293.52NoYes099
48R:R:E245 R:R:I176 46.92954.1NoNo099
49R:R:E245 R:R:H177 19.87528.62NoYes399
50R:R:H177 R:R:R173 18.12224.51YesYes399
51R:R:N174 R:R:R173 14.629814.46NoYes399
52R:R:L169 R:R:N174 13.95595.49NoNo099
53R:R:E245 R:R:L357 26.49735.3NoYes399
54R:R:K286 R:R:W295 48.03759.28YesYes089
55R:R:R225 R:R:W295 47.140524.99NoYes089
56R:R:R225 R:R:V221 47.29236.54NoNo084
57R:R:R201 R:R:V221 47.46993.92NoNo044
58R:R:R201 R:R:W215 47.715816.99NoYes042
59R:R:R308 R:R:W304 22.171613YesYes166
60R:R:F312 R:R:R308 12.65676.41NoYes056
61R:R:F312 R:R:V311 10.14932.62NoNo058
62R:R:L357 R:R:L358 24.84294.15YesYes399
63R:R:L358 R:R:N318 15.344712.36YesNo099
64R:R:I321 R:R:N318 14.64354.25NoNo089
65R:R:G246 R:R:I321 13.23193.53NoNo098
66R:R:G246 R:R:L249 12.52161.71NoNo099
67R:R:I325 R:R:L249 10.34675.71NoNo1399
68L:L:H1 L:L:Q3 36.33092.47YesYes100
69L:L:F6 R:R:Y145 18.2366.19YesYes107
70R:R:Q232 R:R:W304 16.3544.38YesYes176
71R:R:Y145 R:R:Y149 14.10775.96YesYes178
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:H1 R:R:Q232 6.18 1 Yes Yes 0 7 0 1
L:L:H1 R:R:I235 11.93 1 Yes No 0 5 0 1
L:L:H1 R:R:W304 3.17 1 Yes Yes 0 6 0 1
L:L:?2 R:R:L382 5.3 1 Yes Yes 0 5 0 1
L:L:?2 R:R:D385 5.2 1 Yes No 0 7 0 1
L:L:?2 R:R:L386 3.98 1 Yes Yes 0 7 0 1
L:L:Q3 R:R:Y145 6.76 1 Yes Yes 0 7 0 1
L:L:Q3 R:R:Y149 3.38 1 Yes Yes 0 8 0 1
L:L:Q3 R:R:L386 2.66 1 Yes Yes 0 7 0 1
L:L:G4 R:R:W304 2.81 1 No Yes 0 6 0 1
L:L:T5 R:R:W304 3.64 1 Yes Yes 0 6 0 1
L:L:T5 R:R:D370 5.78 1 Yes Yes 0 4 0 1
L:L:T5 R:R:R378 2.59 1 Yes Yes 0 4 0 1
L:L:T5 R:R:L382 4.42 1 Yes Yes 0 5 0 1
L:L:F6 R:R:Y138 6.19 1 Yes No 0 5 0 1
L:L:F6 R:R:F141 3.22 1 Yes No 0 6 0 1
L:L:F6 R:R:Y145 6.19 1 Yes Yes 0 7 0 1
L:L:F6 R:R:L382 7.31 1 Yes Yes 0 5 0 1
L:L:F6 R:R:L386 9.74 1 Yes Yes 0 7 0 1
L:L:T7 R:R:T296 4.71 0 No No 0 5 0 1
L:L:S8 R:R:N298 2.98 0 No No 0 6 0 1
L:L:D9 R:R:R378 8.34 0 No Yes 0 4 0 1
L:L:K10 R:R:Q142 13.56 1 No Yes 0 5 0 1
L:L:S11 R:R:S297 3.26 0 No No 0 4 0 1
L:L:Y13 R:R:Q131 5.64 0 No No 0 3 0 1
L:L:Y13 R:R:A135 4 0 No No 0 3 0 1
L:L:L14 R:R:L198 4.15 0 Yes No 0 6 0 1
L:L:L14 R:R:Y202 15.24 0 Yes Yes 0 1 0 1
L:L:D15 R:R:V28 5.84 0 No No 0 3 0 1
L:L:D15 R:R:M29 5.54 0 No Yes 0 5 0 1
L:L:D15 R:R:Y202 6.9 0 No Yes 0 1 0 1
L:L:E16 R:R:V28 2.85 0 No No 0 3 0 1
L:L:A18 R:R:Y202 2.67 2 No Yes 0 1 0 1
L:L:A18 R:R:W215 2.59 2 No Yes 0 2 0 1
L:L:Q20 R:R:W87 3.29 0 No Yes 0 3 0 1
L:L:D21 R:R:K205 4.15 0 No No 0 4 0 1
L:L:D21 R:R:I206 2.8 0 No No 0 4 0 1
L:L:F22 R:R:M29 4.98 2 Yes Yes 0 5 0 1
L:L:F22 R:R:L32 6.09 2 Yes No 0 4 0 1
L:L:F22 R:R:W36 8.02 2 Yes Yes 0 6 0 1
L:L:W25 R:R:I206 5.87 2 Yes No 0 4 0 1
L:L:W25 R:R:G207 2.81 2 Yes No 0 1 0 1
L:L:L26 R:R:W36 6.83 2 Yes Yes 0 6 0 1
L:L:L26 R:R:Y84 3.52 2 Yes Yes 0 5 0 1
L:L:L27 R:R:Y65 9.38 0 No Yes 0 6 0 1
L:L:L27 R:R:Q120 2.66 0 No No 0 5 0 1
R:R:Q27 R:R:S297 7.22 0 No No 5 4 2 1
R:R:L32 R:R:M29 2.83 2 No Yes 4 5 1 1
R:R:M29 R:R:W215 4.65 2 Yes Yes 5 2 1 1
R:R:L32 R:R:P86 3.28 2 No Yes 4 3 1 1
R:R:F33 R:R:W36 4.01 0 No Yes 4 6 2 1
R:R:K64 R:R:W36 3.48 0 No Yes 4 6 2 1
R:R:W36 R:R:Y84 7.72 2 Yes Yes 6 5 1 1
R:R:D209 R:R:W36 4.47 0 No Yes 4 6 2 1
R:R:Y39 R:R:Y84 16.88 2 Yes Yes 6 5 2 1
R:R:S66 R:R:Y65 2.54 0 No Yes 5 6 2 1
R:R:P82 R:R:Y65 9.74 2 No Yes 8 6 2 1
R:R:Y65 R:R:Y84 3.97 2 Yes Yes 6 5 1 1
R:R:P82 R:R:Y84 5.56 2 No Yes 8 5 2 1
R:R:L85 R:R:P82 3.28 2 No No 6 8 2 2
R:R:L85 R:R:P86 3.28 2 No Yes 6 3 2 1
R:R:L85 R:R:W87 6.83 2 No Yes 6 3 2 1
R:R:P86 R:R:W87 6.76 2 Yes Yes 3 3 1 1
R:R:V91 R:R:W87 4.9 2 Yes Yes 6 3 2 1
R:R:M123 R:R:W87 12.8 0 No Yes 3 3 2 1
R:R:Q120 R:R:Q122 3.84 0 No No 5 3 1 2
R:R:Q131 R:R:V130 2.87 0 No No 3 1 1 2
R:R:M137 R:R:Y138 5.99 0 Yes No 4 5 2 1
R:R:F141 R:R:M137 11.2 0 No Yes 6 4 1 2
L:L:?29 R:R:S139 11.37 1 Yes No 0 3 0 1
R:R:F141 R:R:F383 11.79 0 No No 6 5 1 2
R:R:Q142 R:R:Y145 4.51 1 Yes Yes 5 7 1 1
R:R:D195 R:R:Q142 5.22 1 No Yes 7 5 2 1
R:R:Q142 R:R:R199 3.5 1 Yes Yes 5 4 1 1
L:L:?29 R:R:Q142 17.63 1 Yes Yes 0 5 0 1
L:L:?29 R:R:V143 4.23 1 Yes No 0 4 0 1
R:R:Y145 R:R:Y149 5.96 1 Yes Yes 7 8 1 1
R:R:D195 R:R:Y145 4.6 1 No Yes 7 7 2 1
L:L:?29 R:R:T146 2.79 1 Yes No 0 7 0 1
R:R:S152 R:R:Y149 2.54 0 No Yes 9 8 2 1
R:R:V191 R:R:Y149 3.79 0 No Yes 7 8 2 1
R:R:S390 R:R:Y149 2.54 0 No Yes 9 8 2 1
R:R:I235 R:R:K187 2.91 0 No No 5 8 1 2
L:L:?29 R:R:L192 7.86 1 Yes No 0 7 0 1
R:R:D195 R:R:R199 11.91 1 No Yes 7 4 2 1
R:R:G196 R:R:R199 3 0 No Yes 3 4 2 1
L:L:?29 R:R:R199 36.79 1 Yes Yes 0 4 0 1
R:R:R201 R:R:W215 16.99 0 No Yes 4 2 2 1
R:R:W215 R:R:Y202 10.61 2 Yes Yes 2 1 1 1
R:R:I206 R:R:V212 7.68 0 No No 4 3 1 2
R:R:Q232 R:R:W282 3.29 1 Yes Yes 7 9 1 2
R:R:Q232 R:R:W304 4.38 1 Yes Yes 7 6 1 1
R:R:L307 R:R:Q232 7.99 1 No Yes 7 7 2 1
R:R:L307 R:R:W282 11.39 1 No Yes 7 9 2 2
R:R:N298 R:R:W304 13.56 0 No Yes 6 6 1 1
R:R:R308 R:R:W304 13 1 Yes Yes 6 6 2 1
R:R:D370 R:R:R308 4.76 1 Yes Yes 4 6 1 2
R:R:F365 R:R:K381 4.96 1 Yes No 7 7 2 2
R:R:D385 R:R:F365 11.94 1 No Yes 7 7 1 2
R:R:D370 R:R:R378 3.57 1 Yes Yes 4 4 1 1
R:R:D370 R:R:K381 8.3 1 Yes No 4 7 1 2
R:R:A373 R:R:R378 4.15 0 No Yes 3 4 2 1
R:R:D385 R:R:K381 9.68 1 No No 7 7 1 2
R:R:L382 R:R:L386 2.77 1 Yes Yes 5 7 1 1
L:L:A19 R:R:P86 1.87 0 No Yes 0 3 0 1
R:R:C294 R:R:T296 1.69 0 No No 9 5 2 1
R:R:A228 R:R:T296 1.68 0 No No 5 5 2 1
R:R:S189 R:R:V193 1.62 0 No No 4 5 2 1
R:R:K136 R:R:S139 1.53 0 No No 2 3 2 1
R:R:G375 R:R:R378 1.5 0 No Yes 2 4 2 1
R:R:L197 R:R:V193 1.49 0 No No 4 5 2 1
L:L:?29 R:R:V193 1.41 1 Yes No 0 5 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7V35_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.47
Number of Linked Nodes 379
Number of Links 432
Number of Hubs 64
Number of Links mediated by Hubs 229
Number of Communities 13
Number of Nodes involved in Communities 99
Number of Links involved in Communities 138
Path Summary
Number Of Nodes in MetaPath 72
Number Of Links MetaPath 71
Number of Shortest Paths 126865
Length Of Smallest Path 3
Average Path Length 17.9078
Length of Longest Path 46
Minimum Path Strength 1.185
Average Path Strength 6.41437
Maximum Path Strength 24.4
Minimum Path Correlation 0.7
Average Path Correlation 0.963265
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.22581
Average % Of Corr. Nodes 61.5544
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 57.7259
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • cellular process   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • glucagon receptor activity   • peptide receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • signaling receptor activity   • transmembrane signaling receptor activity   • amide binding   • binding   • peptide hormone binding   • hormone binding   • GTPase regulator activity   • enzyme regulator activity   • guanyl-nucleotide exchange factor activity   • nucleoside-triphosphatase regulator activity   • molecular function regulator activity   • multicellular organismal process   • system process   • circulatory system process   • regulation of blood pressure   • biological regulation   • regulation of biological quality   • blood circulation   • regulation of biosynthetic process   • regulation of biological process   • regulation of cellular process   • positive regulation of biological process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • positive regulation of metabolic process   • biosynthetic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • regulation of macromolecule biosynthetic process   • metabolic process   • cellular process   • positive regulation of macromolecule metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • positive regulation of cellular process   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular response to hormone stimulus   • carbohydrate metabolic process   • energy derivation by oxidation of organic compounds   • glycogen metabolic process   • primary metabolic process   • regulation of generation of precursor metabolites and energy   • generation of precursor metabolites and energy   • regulation of polysaccharide metabolic process   • regulation of primary metabolic process   • glucan metabolic process   • polysaccharide metabolic process   • energy reserve metabolic process   • regulation of glycogen metabolic process   • regulation of carbohydrate metabolic process   • signaling   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to nutrient levels   • response to nutrient levels   • cellular response to stress   • response to stress   • response to starvation   • cellular response to starvation   • cell surface receptor signaling pathway   • response to nutrient   • chemical homeostasis   • homeostatic process   • glucose homeostasis   • carbohydrate homeostasis   • cytoskeletal protein binding   • spectrin binding   • protein-containing complex binding   • protein binding   • enzyme binding   • GTPase binding   • phosphoric ester hydrolase activity   • alkylglycerophosphoethanolamine phosphodiesterase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • hydrolase activity   • catalytic activity   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity, acting on acid anhydrides   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • positive regulation of cytosolic calcium ion concentration   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • response to decreased oxygen levels   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • response to hypoxia   • response to oxygen levels   • response to abiotic stimulus   • cell population proliferation   • phospholipase C-activating G protein-coupled receptor signaling pathway   • muscle cell apoptotic process   • striated muscle cell apoptotic process   • apoptotic process   • cell death   • programmed cell death   • cardiac muscle cell apoptotic process   • photoreceptor inner segment   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • intracellular anatomical structure   • cytoplasm   • membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor outer segment   • photoreceptor cell cilium   • organelle   • ciliary membrane   • photoreceptor outer segment membrane   • bounding membrane of organelle   • plasma membrane region   • organelle membrane   • cell projection membrane   • synapse   • cell junction   • cell body   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • sensory perception of smell   • skeletal system development   • bone development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • coagulation   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • cell-cell signaling   • regulation of protein transport   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • cellular localization   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network
SCOP2Domain Identifier• FnI-like domain   • G protein-coupled receptor-like
SCOP2Family Identifier• FnI-like domain   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeAIB
PDB ResiduesL:L:?2
Environment DetailsOpen EMBL-EBI Page
CodeAIB
Name2-aminoisobutyric acid
Synonymsα-aminoisobutyric acid
Identifier
FormulaC4 H9 N O2
Molecular Weight103.12
SMILES
PubChem5245672
Formal Charge0
Total Atoms16
Total Chiral Atoms0
Total Bonds15
Total Aromatic Bonds0

CodeD6M
PDB ResiduesL:L:?29
Environment DetailsOpen EMBL-EBI Page
CodeD6M
NameN-hexadecanoyl-L-glutamic acid
Synonyms
Identifier
FormulaC21 H39 N O5
Molecular Weight385.538
SMILES
PubChem161955
Formal Charge0
Total Atoms66
Total Chiral Atoms1
Total Bonds65
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP47871
Sequence
>7V35_nogp_Chain_R
QVMDFLFEK WKLYGDQCH HNLSLLPPP TELVCNRTF DKYSCWPDT 
PANTTANIS CPWYLPWHH KVQHRFVFK RCGQWVRGP RGQPWRDAS 
QCQMDGEEI EVQKEVAKM YSSFQVMYT VGYSLSLGA LLLALAILG 
GLSKLHCTR NAIHANLFA SFVLKASSV LVIDGLLRT RYSQKIGDD 
LSVSTWLSD GAVAGCRVA AVFMQYGIV ANYCWLLVE GLYLHNLLG 
LATLPERSF FSLYLGIGW GAPMLFVVP WAVVKCLFE NVQCWTSND 
NMGFWWILR FPVFLAILI NFFIFVRIV QLLVAKLRA RQMHHTDYK 
FRLAKSTLT LIPLLGVHE VVFAFVTDE HAQGTLRSA KLFFDLFLS 
SFQGLLVAV LYCFLNKEV QSELRRRWH RWRLG


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6ORVB1PeptideGlucagonGLP-1Homo sapiens-TT-OAD2Gs/β1/γ232020-01-08doi.org/10.1038/s41586-019-1902-z
6ORV (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-TT-OAD232020-01-08doi.org/10.1038/s41586-019-1902-z
7E14B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 156022738Gs/β1/γ22.92021-07-07doi.org/10.1038/s41467-021-24058-z
7E14 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 1560227382.92021-07-07doi.org/10.1038/s41467-021-24058-z
7DUQB1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 156022738Gs/β1/γ22.52021-07-14doi.org/10.1038/s41467-021-24058-z
7DUQ (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 1560227382.52021-07-14doi.org/10.1038/s41467-021-24058-z
7DURB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ23.32021-08-11doi.org/10.1038/s41467-021-24058-z
7DUR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227383.32021-08-11doi.org/10.1038/s41467-021-24058-z
7EVMB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ22.52021-08-11doi.org/10.1038/s41467-021-24058-z
7EVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227382.52021-08-11doi.org/10.1038/s41467-021-24058-z
5VEWB1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.72017-05-24doi.org/10.1038/nature22378
6LN2B1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-3.22020-03-18doi.org/10.1038/s41467-020-14934-5
6KJVB1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.82019-11-13doi.org/10.1107/S2052252519013496
6KK1B1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.82019-11-13doi.org/10.1107/S2052252519013496
6KK7B1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-3.12019-11-13doi.org/10.1107/S2052252519013496
8WG8B1PeptideGlucagonGlucagonHomo sapiens-Peptidechim(NtGi1-Gs)/β1/γ22.712024-03-06doi.org/10.1038/s41421-024-00649-0
8WG8 (No Gprot) B1PeptideGlucagonGlucagonHomo sapiens-Peptide2.712024-03-06doi.org/10.1038/s41421-024-00649-0
5VEXB1PeptideGlucagonGLP-1Homo sapiens-NNC0640-32017-05-17doi.org/10.1038/nature22378
5XEZB1PeptideGlucagonGlucagonHomo sapiens-NNC0640-32017-05-24doi.org/10.1038/nature22363
5XF1B1PeptideGlucagonGlucagonHomo sapiens-NNC0640-3.192017-05-24doi.org/10.1038/nature22363
5EE7B1PeptideGlucagonGlucagonHomo sapiens-MK0893-2.52016-04-20doi.org/10.1038/nature17414
7RBTB1PeptideGlucagonGIPHomo sapiensTirzepatideLSN3556672chim(NtGi1-Gs)/β1/γ23.082022-04-13doi.org/10.1073/pnas.2116506119
7RBT (No Gprot) B1PeptideGlucagonGIPHomo sapiensTirzepatideLSN35566723.082022-04-13doi.org/10.1073/pnas.2116506119
9IVMB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN3318839chim(NtGi1-Gs)/β2/γ23.222024-11-13doi.org/10.1016/j.apsb.2024.09.002
9IVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN33188393.222024-11-13doi.org/10.1016/j.apsb.2024.09.002
6VCBB1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN3160440Gs/β1/γ23.32020-07-22doi.org/10.1038/s41589-020-0589-7
6VCB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN31604403.32020-07-22doi.org/10.1038/s41589-020-0589-7
7CZ5B1PeptideGlucagonGHRHHomo sapiensSomatoliberin-Gs/β1/γ22.62020-11-18doi.org/10.1038/s41467-020-18945-0
7CZ5 (No Gprot) B1PeptideGlucagonGHRHHomo sapiensSomatoliberin-2.62020-11-18doi.org/10.1038/s41467-020-18945-0
7V9MB1PeptideGlucagonGHRH (SV1)Homo sapiensSomatoliberin-Gs/β1/γ23.292021-10-20doi.org/10.1073/pnas.2106606118
7V9M (No Gprot) B1PeptideGlucagonGHRH (SV1)Homo sapiensSomatoliberin-3.292021-10-20doi.org/10.1073/pnas.2106606118
7V9LB1PeptideGlucagonGHRH (SV1)Homo sapiens--chim(NtGi1-Gs)/β1/γ22.62022-04-06doi.org/10.1073/pnas.2106606118
7V9L (No Gprot) B1PeptideGlucagonGHRH (SV1)Homo sapiens--2.62022-04-06doi.org/10.1073/pnas.2106606118
8WA3B1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ22.862024-03-06doi.org/10.1038/s41421-024-00649-0
8WA3 (No Gprot) B1PeptideGlucagonGIPHomo sapiens--2.862024-03-06doi.org/10.1038/s41421-024-00649-0
7FINB1PeptideGlucagonGIPHomo sapiensPeptide-20; GGL-Gs/β1/γ23.12022-02-23doi.org/10.1038/s41467-022-28683-0
7FIN (No Gprot) B1PeptideGlucagonGIPHomo sapiensPeptide-20; GGL-3.12022-02-23doi.org/10.1038/s41467-022-28683-0
7FIYB1PeptideGlucagonGIPHomo sapiensTirzepatide-Gs/β1/γ23.42022-03-02doi.org/10.1038/s41467-022-28683-0
7FIY (No Gprot) B1PeptideGlucagonGIPHomo sapiensTirzepatide-3.42022-03-02doi.org/10.1038/s41467-022-28683-0
7VABB1PeptideGlucagonGIPHomo sapiensNon-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ23.22022-03-02doi.org/10.1038/s41467-022-28683-0
7VAB (No Gprot) B1PeptideGlucagonGIPHomo sapiensNon-Acylated Tirzepatide-3.22022-03-02doi.org/10.1038/s41467-022-28683-0
7RA3B1PeptideGlucagonGIPHomo sapiensGIP-chim(NtGi1-Gs)/β1/γ23.242022-04-13doi.org/10.1073/pnas.2116506119
7RA3 (No Gprot) B1PeptideGlucagonGIPHomo sapiensGIP-3.242022-04-13doi.org/10.1073/pnas.2116506119
8ITLB1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ23.232023-10-18doi.org/10.1073/pnas.2306145120
8ITL (No Gprot) B1PeptideGlucagonGIPHomo sapiens--3.232023-10-18doi.org/10.1073/pnas.2306145120
8ITMB1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ23.132023-10-18doi.org/10.1073/pnas.2306145120
8ITM (No Gprot) B1PeptideGlucagonGIPHomo sapiens--3.132023-10-18doi.org/10.1073/pnas.2306145120
7DTYB1PeptideGlucagonGIPHomo sapiensGIP-Gs/β1/γ22.982021-08-04doi.org/10.7554/eLife.68719
7DTY (No Gprot) B1PeptideGlucagonGIPHomo sapiensGIP-2.982021-08-04doi.org/10.7554/eLife.68719
8YW4B1PeptideGlucagonGIPHomo sapiensRetatrutide-chim(NtGi1-Gs)/β1/γ23.262024-09-18doi.org/10.1038/s41421-024-00700-0
8YW4 (No Gprot) B1PeptideGlucagonGIPHomo sapiensRetatrutide-3.262024-09-18doi.org/10.1038/s41421-024-00700-0
9IVGB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ232024-11-27doi.org/10.1016/j.apsb.2024.09.002
9IVG (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-32024-11-27doi.org/10.1016/j.apsb.2024.09.002
7RTBB1PeptideGlucagonGLP-1Homo sapiensPeptide-19-Gs/β1/γ22.142021-10-06doi.org/10.1016/j.bbrc.2021.09.016
7RTB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-19-2.142021-10-06doi.org/10.1016/j.bbrc.2021.09.016
7KI0B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-Gs/β1/γ22.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7KI0 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-2.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7KI1B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-Gs/β1/γ22.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7KI1 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-2.52021-08-04doi.org/10.1016/j.celrep.2021.109374
6X18B1PeptideGlucagonGLP-1Homo sapiensGLP-1-Gs/β1/γ22.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X18 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1-2.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X19B1PeptideGlucagonGLP-1Homo sapiensCHU-128-Gs/β1/γ22.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X19 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensCHU-128-2.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X1AB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.52020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X1A (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.52020-09-09doi.org/10.1016/j.molcel.2020.09.020
7LCIB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.92021-01-20doi.org/10.1016/j.str.2021.04.008
7LCI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.92021-01-20doi.org/10.1016/j.str.2021.04.008
7LCJB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--2.822021-01-20doi.org/10.1016/j.str.2021.04.008
7LCKB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--3.242021-01-20doi.org/10.1016/j.str.2021.04.008
7S15B1PeptideGlucagonGLP-1Homo sapiensPubChem 134611223--3.82022-06-08doi.org/10.1021/acs.jmedchem.1c01856
9J1PB1PeptideGlucagonGLP-1Homo sapiensg1:Ox-chim(NtGi1-Gs)/β1/γ22.992025-02-26doi.org/10.1021/jacs.4c12808
9J1P (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensg1:Ox-2.992025-02-26doi.org/10.1021/jacs.4c12808
5VAIB1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-Gs/β1/γ24.12017-05-24doi.org/10.1038/nature22394
5VAI (No Gprot) B1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-4.12017-05-24doi.org/10.1038/nature22394
5NX2B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)--3.72017-06-14doi.org/10.1038/nature22800
6B3JB1PeptideGlucagonGLP-1Homo sapiensExendin-P5-Gs/β1/γ23.32018-02-21doi.org/10.1038/nature25773
6B3J (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-P5-3.32018-02-21doi.org/10.1038/nature25773
8WG7B1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.542024-03-06doi.org/10.1038/s41421-024-00649-0
8WG7 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.542024-03-06doi.org/10.1038/s41421-024-00649-0
7C2EB1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-Gs/β1/γ24.22020-08-26doi.org/10.1038/s41422-020-0384-8
7C2E (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-4.22020-08-26doi.org/10.1038/s41422-020-0384-8
7LLLB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/β1/γ23.72022-01-12doi.org/10.1038/s41467-021-27760-0
7LLL (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-4-3.72022-01-12doi.org/10.1038/s41467-021-27760-0
7LLYB1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-Gs/β1/γ23.32022-01-12doi.org/10.1038/s41467-021-27760-0
7LLY (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-3.32022-01-12doi.org/10.1038/s41467-021-27760-0
7FIMB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-Gs/β1/γ23.42022-03-02doi.org/10.1038/s41467-022-28683-0
7FIM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-3.42022-03-02doi.org/10.1038/s41467-022-28683-0
7VBIB1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-Gs/β1/γ232022-03-02doi.org/10.1038/s41467-022-28683-0
7VBI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-32022-03-02doi.org/10.1038/s41467-022-28683-0
7VBHB1PeptideGlucagonGLP-1Homo sapiensPeptide-20-Gs/β1/γ232022-04-06doi.org/10.1038/s41467-022-28683-0
7VBH (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-20-32022-04-06doi.org/10.1038/s41467-022-28683-0
7S1MB1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-Gs/β1/γ22.412022-01-05doi.org/10.1038/s41589-021-00945-w
7S1M (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-2.412022-01-05doi.org/10.1038/s41589-021-00945-w
7S3IB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.512022-01-05doi.org/10.1038/s41589-021-00945-w
7S3I (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.512022-01-05doi.org/10.1038/s41589-021-00945-w
6XOXB1PeptideGlucagonGLP-1Homo sapiensOrforglipron-chim(NtGi1-Gs)/β1/γ23.12020-11-18doi.org/10.1073/pnas.2014879117
6XOX (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipron-3.12020-11-18doi.org/10.1073/pnas.2014879117
7RG9B1PeptideGlucagonGLP-1Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22022-04-13doi.org/10.1073/pnas.2116506119
7RG9 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.22022-04-13doi.org/10.1073/pnas.2116506119
7RGPB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-chim(NtGi1-Gs)/β1/γ22.92022-04-13doi.org/10.1073/pnas.2116506119
7RGP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-2.92022-04-13doi.org/10.1073/pnas.2116506119
7X8RB1PeptideGlucagonGLP-1Homo sapiensBOC5-Gs/β1/γ22.612022-06-29doi.org/10.1073/pnas.2200155119
7X8R (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensBOC5-2.612022-06-29doi.org/10.1073/pnas.2200155119
7X8SB1PeptideGlucagonGLP-1Homo sapiensWB4-24-Gs/β1/γ23.092022-06-29doi.org/10.1073/pnas.2200155119
7X8S (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensWB4-24-3.092022-06-29doi.org/10.1073/pnas.2200155119
8JIPB1PeptideGlucagonGLP-1Homo sapiensMEDI0382-chim(NtGi1-Gs)/β1/γ22.852023-09-06doi.org/10.1073/pnas.2303696120
8JIP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensMEDI0382-2.852023-09-06doi.org/10.1073/pnas.2303696120
8JIRB1PeptideGlucagonGLP-1Homo sapiensSAR425899-chim(NtGi1-Gs)/β1/γ22.572023-09-06doi.org/10.1073/pnas.2303696120
8JIR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSAR425899-2.572023-09-06doi.org/10.1073/pnas.2303696120
8JISB1PeptideGlucagonGLP-1Homo sapiensPeptide-15-chim(NtGi1-Gs)/β1/γ22.462023-11-08doi.org/10.1073/pnas.2303696120
8JIS (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-15-2.462023-11-08doi.org/10.1073/pnas.2303696120
8YW3B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-Gs/β1/γ22.682024-09-18doi.org/10.1038/s41421-024-00700-0
8YW3 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-2.682024-09-18doi.org/10.1038/s41421-024-00700-0
9EBNB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ23.442025-03-26doi.org/10.1073/pnas.2407574122
9EBN (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.442025-03-26doi.org/10.1073/pnas.2407574122
9EBOB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (ACPC18)-Gs/β1/γ23.132025-03-26doi.org/10.1073/pnas.2407574122
9EBO (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (ACPC18)-3.132025-03-26doi.org/10.1073/pnas.2407574122
9EBQB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ23.162025-03-26doi.org/10.1073/pnas.2407574122
9EBQ (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.162025-03-26doi.org/10.1073/pnas.2407574122
8YWFB1PeptideGlucagonGLP-1Homo sapiensRetatrutide-chim(NtGi1-Gs)/β1/γ22.742025-04-16To be published
8YWF (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-2.742025-04-16To be published
9BYOB1PeptideGlucagonGLP-1Homo sapiensExendin-3-Gs/β1/γ22.312025-06-11To be published
9BYO (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-3-2.312025-06-11To be published
9C0KB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/β1/γ22.722025-06-11To be published
9C0K (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-4-2.722025-06-11To be published
7D68B1PeptideGlucagonGLP-2Homo sapiensGLP-2-Gs/β1/γ232020-12-16doi.org/10.1038/s41422-020-00442-0
7D68 (No Gprot) B1PeptideGlucagonGLP-2Homo sapiensGLP-2-32020-12-16doi.org/10.1038/s41422-020-00442-0
8FU6B1PeptideGlucagonGlucagonHomo sapiensGlucagon derivative ZP3780-Gs/β1/γ22.92023-04-12doi.org/10.1016/j.cell.2023.02.028
8FU6 (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlucagon derivative ZP3780-2.92023-04-12doi.org/10.1016/j.cell.2023.02.028
4L6RB1PeptideGlucagonGlucagonHomo sapiens---3.32013-07-24doi.org/10.1038/nature12393
5YQZB1PeptideGlucagonGlucagonHomo sapiensGlucagon analogue--32018-01-17doi.org/10.1038/nature25153
7V35B1PeptideGlucagonGlucagonHomo sapiensPeptide-20-Gs/β1/γ23.52022-03-02doi.org/10.1038/s41467-022-28683-0
7V35 (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensPeptide-20-3.52022-03-02doi.org/10.1038/s41467-022-28683-0
8JRUB1PeptideGlucagonGlucagonHomo sapiens--Arrestin23.52023-08-16doi.org/10.1038/s41586-023-06420-x
8JRVB1PeptideGlucagonGlucagonHomo sapiensGlucagon-Arrestin23.32023-08-16doi.org/10.1038/s41586-023-06420-x
8JITB1PeptideGlucagonGlucagonHomo sapiensMEDI0382-Gs/β1/γ22.912023-09-06doi.org/10.1073/pnas.2303696120
8JIT (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensMEDI0382-2.912023-09-06doi.org/10.1073/pnas.2303696120
8JIQB1PeptideGlucagonGlucagonHomo sapiensPeptide-15-Gs/β1/γ23.42023-09-13doi.org/10.1073/pnas.2303696120
8JIQ (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensPeptide-15-3.42023-09-13doi.org/10.1073/pnas.2303696120
8JIUB1PeptideGlucagonGlucagonHomo sapiensSAR425899-Gs/β1/γ22.762023-09-13doi.org/10.1073/pnas.2303696120
8JIU (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensSAR425899-2.762023-09-13doi.org/10.1073/pnas.2303696120
6WHCB1PeptideGlucagonGlucagonHomo sapiensGlu16 analog of GCG-Gs/β1/γ23.42020-05-27doi.org/10.1074/jbc.RA120.013793
6WHC (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlu16 analog of GCG-3.42020-05-27doi.org/10.1074/jbc.RA120.013793
6LMKB1PeptideGlucagonGlucagonHomo sapiensGlucagon-Gs/β1/γ23.72020-04-01doi.org/10.1126/science.aaz5346
6LMK (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlucagon-3.72020-04-01doi.org/10.1126/science.aaz5346
6LMLB1PeptideGlucagonGlucagonHomo sapiensGlucagon-Gi1/β1/γ13.92020-04-01doi.org/10.1126/science.aaz5346
6LML (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlucagon-3.92020-04-01doi.org/10.1126/science.aaz5346
6WPWB1PeptideGlucagonGlucagonHomo sapiensGlucagon derivative ZP3780-Gs/β1/γ23.12020-08-12doi.org/10.1126/science.aba3373
6WPW (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlucagon derivative ZP3780-3.12020-08-12doi.org/10.1126/science.aba3373
8YW5B1PeptideGlucagonGlucagonHomo sapiensRetatrutide-Gs/β1/γ22.842024-09-18doi.org/10.1038/s41421-024-00700-0
8YW5 (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensRetatrutide-2.842024-09-18doi.org/10.1038/s41421-024-00700-0
7D3SB1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/β1/γ22.92020-11-04doi.org/10.1016/j.bbrc.2020.08.042
7D3S (No Gprot) B1PeptideGlucagonSecretinHomo sapiensSecretin-2.92020-11-04doi.org/10.1016/j.bbrc.2020.08.042
6WI9B1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/β1/γ24.32020-08-12doi.org/10.1038/s41467-020-17791-4
6WI9 (No Gprot) B1PeptideGlucagonSecretinHomo sapiensSecretin-4.32020-08-12doi.org/10.1038/s41467-020-17791-4
6WZGB1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/β1/γ22.32020-08-12doi.org/10.1038/s41467-020-17791-4
6WZG (No Gprot) B1PeptideGlucagonSecretinHomo sapiensSecretin-2.32020-08-12doi.org/10.1038/s41467-020-17791-4




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7V35_nogp.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.