psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:H1	R:R:W304	8.46	No	Yes	0	0	6
2	L:L:H1	R:R:R308	18.05	No	No	0	0	6
3	L:L:H1	R:R:V311	12.45	No	No	0	0	8
4	L:L:S2	L:L:T5	3.2	No	No	0	0	0
5	L:L:S2	R:R:D385	5.89	No	Yes	0	0	7
6	L:L:F6	L:L:Q3	3.51	No	No	0	0	0
7	L:L:Q3	L:L:T7	2.83	No	No	0	0	0
8	L:L:G4	R:R:W304	2.81	No	Yes	0	0	6
9	L:L:F6	R:R:Y145	7.22	No	Yes	0	0	7
10	L:L:F6	R:R:L386	3.65	No	No	0	0	7
11	L:L:K12	L:L:S8	3.06	No	No	0	0	0
12	L:L:S8	R:R:N298	8.94	No	No	0	0	6
13	L:L:D9	R:R:Y138	8.05	No	No	0	0	5
14	L:L:L14	L:L:Y10	8.21	No	Yes	0	0	0
15	L:L:Y10	R:R:Q142	10.15	Yes	Yes	5	0	5
16	L:L:Y10	R:R:L198	4.69	Yes	No	0	0	6
17	L:L:Y10	R:R:R199	9.26	Yes	Yes	5	0	4
18	L:L:D15	L:L:S11	2.94	Yes	No	3	0	0
19	L:L:S11	R:R:T296	6.4	No	Yes	3	0	5
20	L:L:S11	R:R:S297	6.52	No	No	3	0	4
21	L:L:K12	R:R:Q27	5.42	No	Yes	0	0	5
22	L:L:L14	L:L:Y13	3.52	No	Yes	0	0	0
23	L:L:Q17	L:L:Y13	3.38	Yes	Yes	0	0	0
24	L:L:Y13	R:R:A135	2.67	Yes	No	0	0	3
25	L:L:Y13	R:R:Y138	5.96	Yes	No	0	0	5
26	L:L:L14	R:R:Y202	11.72	No	Yes	0	0	1
27	L:L:D15	R:R:Q27	7.83	Yes	Yes	3	0	5
28	L:L:D15	R:R:Y202	8.05	Yes	Yes	0	0	1
29	L:L:D15	R:R:Q293	3.92	Yes	Yes	3	0	4
30	L:L:E16	R:R:W87	5.45	No	No	0	0	3
31	L:L:K20	L:L:Q17	2.71	No	Yes	0	0	0
32	L:L:Q17	R:R:Q131	5.12	Yes	No	0	0	3
33	L:L:A18	L:L:E21	3.02	No	No	0	0	0
34	L:L:A18	R:R:M29	3.22	No	No	0	0	5
35	L:L:A24	L:L:K20	3.21	No	No	0	0	0
36	L:L:E21	R:R:K205	12.15	No	No	0	0	4
37	L:L:F22	L:L:W25	8.02	Yes	Yes	6	0	0
38	L:L:F22	R:R:M29	6.22	Yes	No	0	0	5
39	L:L:F22	R:R:L32	4.87	Yes	No	0	0	4
40	L:L:F22	R:R:W36	3.01	Yes	Yes	6	0	6
41	L:L:F22	R:R:D209	4.78	Yes	Yes	6	0	4
42	L:L:I23	R:R:W87	4.7	No	No	0	0	3
43	L:L:L26	L:L:W25	10.25	No	Yes	0	0	0
44	L:L:W25	R:R:D208	8.93	Yes	No	0	0	4
45	L:L:W25	R:R:D209	14.52	Yes	Yes	6	0	4
46	L:L:L26	R:R:W36	4.56	No	Yes	0	0	6
47	L:L:L26	R:R:Y65	5.86	No	Yes	0	0	6
48	L:L:M27	R:R:Y65	16.76	No	Yes	1	0	6
49	L:L:M27	R:R:W115	8.14	No	Yes	1	0	4
50	L:L:M27	R:R:S119	6.13	No	No	0	0	5
51	L:L:T29	R:R:R111	3.88	No	No	0	0	4
52	R:R:D30	R:R:Q27	3.92	No	Yes	3	5	5
53	R:R:Q27	R:R:Q293	7.68	Yes	Yes	3	5	4
54	R:R:Q27	R:R:S297	10.11	Yes	No	3	5	4
55	R:R:D30	R:R:F31	9.55	No	No	0	5	4
56	R:R:D30	R:R:Q293	3.92	No	Yes	3	5	4
57	R:R:F31	R:R:K35	8.69	No	No	0	4	4
58	R:R:L32	R:R:P86	9.85	No	No	0	4	3
59	R:R:E34	R:R:F33	3.5	No	No	0	2	4
60	R:R:F33	R:R:W36	4.01	No	Yes	6	4	6
61	R:R:F33	R:R:K37	12.41	No	No	6	4	3
62	R:R:K37	R:R:W36	3.48	No	Yes	6	3	6
63	R:R:K64	R:R:W36	12.76	No	Yes	0	4	6
64	R:R:Q42	R:R:Y39	6.76	No	Yes	0	5	6
65	R:R:C67	R:R:Y39	5.38	No	Yes	0	9	6
66	R:R:P82	R:R:Y39	6.95	Yes	Yes	1	8	6
67	R:R:W83	R:R:Y39	7.72	No	Yes	1	2	6
68	R:R:Y39	R:R:Y84	5.96	Yes	Yes	1	6	5
69	R:R:H45	R:R:Q42	3.71	No	No	0	4	5
70	R:R:C43	R:R:N46	3.15	Yes	No	0	9	5
71	R:R:C43	R:R:R60	5.57	Yes	No	0	9	4
72	R:R:C43	R:R:C67	7.28	Yes	No	0	9	9
73	R:R:L47	R:R:N46	2.75	No	No	0	5	5
74	R:R:L47	R:R:R60	12.15	No	No	0	5	4
75	R:R:L50	R:R:P51	4.93	No	No	0	3	2
76	R:R:D70	R:R:P53	11.27	No	No	0	4	3
77	R:R:D70	R:R:V57	11.69	No	No	0	4	3
78	R:R:C58	R:R:T71	5.07	No	Yes	8	9	7
79	R:R:C100	R:R:C58	7.28	No	No	8	9	9
80	R:R:C58	R:R:G104	3.92	No	No	0	9	9
81	R:R:F62	R:R:R60	9.62	No	No	0	7	4
82	R:R:D63	R:R:T61	14.45	No	No	1	9	6
83	R:R:T61	R:R:W115	3.64	No	Yes	1	6	4
84	R:R:D63	R:R:W115	14.52	No	Yes	1	9	4
85	R:R:Y65	R:R:Y84	9.93	Yes	Yes	1	6	5
86	R:R:L85	R:R:Y65	4.69	No	Yes	1	6	6
87	R:R:W115	R:R:Y65	10.61	Yes	Yes	1	4	6
88	R:R:K98	R:R:S66	4.59	Yes	No	1	8	5
89	R:R:S66	R:R:W115	17.3	No	Yes	1	5	4
90	R:R:P69	R:R:W68	17.57	No	Yes	0	6	9
91	R:R:T71	R:R:W68	4.85	Yes	Yes	8	7	9
92	R:R:A77	R:R:W68	7.78	No	Yes	8	7	9
93	R:R:I79	R:R:W68	18.79	No	Yes	0	4	9
94	R:R:P72	R:R:T71	6.99	No	Yes	0	1	7
95	R:R:A77	R:R:T71	5.03	No	Yes	8	7	7
96	R:R:C100	R:R:T71	3.38	No	Yes	8	9	7
97	R:R:P72	R:R:T75	6.99	No	No	0	1	5
98	R:R:F97	R:R:T76	6.49	No	No	0	5	5
99	R:R:R99	R:R:T76	7.76	Yes	No	0	3	5
100	R:R:I79	R:R:K98	17.45	No	Yes	0	4	8
101	R:R:F95	R:R:S80	5.28	No	No	0	1	3
102	R:R:C81	R:R:P82	3.77	No	Yes	0	9	8
103	R:R:C121	R:R:C81	7.28	No	No	0	9	9
104	R:R:P82	R:R:W83	2.7	Yes	No	1	8	2
105	R:R:P82	R:R:Y84	12.52	Yes	Yes	1	8	5
106	R:R:L85	R:R:P82	3.28	No	Yes	1	6	8
107	R:R:Q92	R:R:W83	6.57	No	No	0	1	2
108	R:R:L85	R:R:Y84	11.72	No	Yes	1	6	5
109	R:R:M123	R:R:W87	12.8	No	No	0	3	3
110	R:R:H88	R:R:R94	3.39	No	No	10	4	5
111	R:R:C121	R:R:H88	5.9	No	No	10	9	4
112	R:R:K90	R:R:V91	3.04	No	No	0	4	6
113	R:R:H93	R:R:V91	9.69	No	No	0	4	6
114	R:R:Q120	R:R:R94	14.02	No	No	0	5	5
115	R:R:C121	R:R:R94	4.18	No	No	10	9	5
116	R:R:A118	R:R:V96	3.39	No	No	0	5	7
117	R:R:Q120	R:R:V96	4.3	No	No	0	5	7
118	R:R:K98	R:R:W115	4.64	Yes	Yes	1	8	4
119	R:R:K98	R:R:R116	16.09	Yes	No	0	8	6
120	R:R:A118	R:R:K98	6.42	No	Yes	0	5	8
121	R:R:R99	R:R:W106	11	Yes	No	7	3	9
122	R:R:D117	R:R:R99	3.57	No	Yes	7	7	3
123	R:R:C100	R:R:R116	5.57	No	No	0	9	6
124	R:R:D103	R:R:G104	5.03	No	No	0	5	9
125	R:R:Q105	R:R:R108	22.2	No	No	0	5	1
126	R:R:V107	R:R:W106	19.61	Yes	No	7	5	9
127	R:R:D117	R:R:W106	6.7	No	No	7	7	9
128	R:R:Q113	R:R:V107	2.87	No	Yes	7	4	5
129	R:R:P114	R:R:V107	12.37	No	Yes	7	5	5
130	R:R:D117	R:R:V107	2.92	No	Yes	7	7	5
131	R:R:G109	R:R:R108	3	No	No	0	4	1
132	R:R:G109	R:R:P110	4.06	No	No	0	4	3
133	R:R:P110	R:R:R111	5.76	No	No	0	3	4
134	R:R:P114	R:R:Q113	4.74	No	No	7	5	4
135	R:R:E127	R:R:M123	4.06	No	No	0	1	3
136	R:R:D124	R:R:G125	5.03	No	No	0	2	2
137	R:R:G125	R:R:I128	3.53	No	No	0	2	2
138	R:R:E127	R:R:V130	5.7	No	No	0	1	1
139	R:R:I128	R:R:Q131	6.86	No	No	0	2	3
140	R:R:E129	R:R:E133	7.61	No	No	0	1	2
141	R:R:K132	R:R:Q131	4.07	No	No	0	2	3
142	R:R:M137	R:R:V134	6.09	No	No	0	4	2
143	R:R:M137	R:R:Y138	3.59	No	No	0	4	5
144	R:R:F141	R:R:F383	4.29	No	No	0	6	5
145	R:R:Q142	R:R:Y145	12.4	Yes	Yes	5	5	7
146	R:R:Q142	R:R:T146	4.25	Yes	No	5	5	7
147	R:R:D195	R:R:Q142	5.22	Yes	Yes	5	7	5
148	R:R:Q142	R:R:R199	4.67	Yes	Yes	5	5	4
149	R:R:F383	R:R:M144	4.98	No	No	0	5	6
150	R:R:T146	R:R:Y145	3.75	No	Yes	5	7	7
151	R:R:Y145	R:R:Y149	4.96	Yes	Yes	0	7	8
152	R:R:D195	R:R:Y145	11.49	Yes	Yes	5	7	7
153	R:R:L192	R:R:T146	2.95	No	No	0	7	7
154	R:R:S150	R:R:V147	3.23	No	No	0	7	5
155	R:R:F391	R:R:G148	4.52	No	No	0	7	7
156	R:R:A188	R:R:Y149	4	No	Yes	0	8	8
157	R:R:V191	R:R:Y149	6.31	No	Yes	0	7	8
158	R:R:L192	R:R:Y149	3.52	No	Yes	0	7	8
159	R:R:S390	R:R:Y149	10.17	No	Yes	0	9	8
160	R:R:L151	R:R:L394	2.77	No	No	0	5	5
161	R:R:G393	R:R:S152	3.71	No	No	0	9	9
162	R:R:L394	R:R:S152	4.5	No	No	0	5	9
163	R:R:A188	R:R:L153	3.15	No	No	0	8	6
164	R:R:F181	R:R:L156	6.09	Yes	Yes	4	8	8
165	R:R:F184	R:R:L156	4.87	Yes	Yes	0	8	8
166	R:R:L156	R:R:V185	4.47	Yes	No	0	8	8
167	R:R:A397	R:R:L156	3.15	No	Yes	4	8	8
168	R:R:I162	R:R:L158	4.28	No	No	0	8	5
169	R:R:A159	R:R:F181	2.77	No	Yes	4	9	8
170	R:R:A159	R:R:C401	3.61	No	Yes	4	9	9
171	R:R:A159	R:R:F402	2.77	No	Yes	4	9	9
172	R:R:F181	R:R:L160	3.65	Yes	No	0	8	6
173	R:R:C401	R:R:I162	3.27	Yes	No	4	9	8
174	R:R:F402	R:R:I162	3.77	Yes	No	4	9	8
175	R:R:G164	R:R:L163	3.42	No	Yes	0	3	8
176	R:R:K168	R:R:L163	2.82	Yes	Yes	0	8	8
177	R:R:C401	R:R:L163	3.17	Yes	Yes	0	9	8
178	R:R:E410	R:R:L166	5.3	No	No	0	8	7
179	R:R:K168	R:R:N174	2.8	Yes	No	0	8	9
180	R:R:K168	R:R:V407	4.55	Yes	No	0	8	9
181	R:R:C171	R:R:H170	7.37	No	No	0	7	7
182	R:R:C171	R:R:N174	6.3	No	No	0	7	9
183	R:R:T172	R:R:Y248	8.74	No	Yes	0	7	8
184	R:R:R173	R:R:Y248	4.12	No	Yes	0	9	8
185	R:R:E406	R:R:R173	5.82	No	No	0	9	9
186	R:R:E245	R:R:I176	4.1	No	No	0	9	9
187	R:R:I176	R:R:Y248	4.84	No	Yes	0	9	8
188	R:R:E245	R:R:H177	9.85	No	No	0	9	9
189	R:R:H177	R:R:Y400	6.53	No	Yes	0	9	8
190	R:R:N179	R:R:W241	6.78	No	Yes	0	8	9
191	R:R:F184	R:R:L180	4.87	Yes	No	0	8	9
192	R:R:L180	R:R:W241	4.56	No	Yes	0	9	9
193	R:R:F181	R:R:V396	3.93	Yes	No	0	8	9
194	R:R:A397	R:R:F181	2.77	No	Yes	4	8	8
195	R:R:C401	R:R:F181	2.79	Yes	Yes	4	9	8
196	R:R:N238	R:R:S183	2.98	Yes	No	0	9	9
197	R:R:F184	R:R:N238	19.33	Yes	Yes	0	8	9
198	R:R:F184	R:R:Q392	11.71	Yes	No	0	8	9
199	R:R:F184	R:R:G393	6.02	Yes	No	0	8	9
200	R:R:F230	R:R:L186	9.74	No	No	0	4	7
201	R:R:I235	R:R:K187	2.91	No	No	0	5	8
202	R:R:K187	R:R:N238	6.99	No	Yes	0	8	9
203	R:R:K187	R:R:Y239	3.58	No	No	0	8	8
204	R:R:M231	R:R:S190	6.13	Yes	No	0	6	5
205	R:R:D195	R:R:V191	4.38	Yes	No	0	7	7
206	R:R:M231	R:R:V191	3.04	Yes	No	0	6	7
207	R:R:A227	R:R:I194	3.25	No	No	0	6	6
208	R:R:I194	R:R:M231	2.92	No	Yes	0	6	6
209	R:R:I194	R:R:T296	3.04	No	Yes	0	6	5
210	R:R:L198	R:R:Y202	3.52	No	Yes	0	6	1
211	R:R:L198	R:R:T296	5.9	No	Yes	0	6	5
212	R:R:S203	R:R:T200	3.2	No	No	0	4	3
213	R:R:Q204	R:R:T200	5.67	No	No	0	4	3
214	R:R:R201	R:R:Y202	6.17	Yes	Yes	0	4	1
215	R:R:L216	R:R:R201	12.15	No	Yes	0	2	4
216	R:R:A220	R:R:R201	4.15	No	Yes	0	6	4
217	R:R:R201	R:R:V221	3.92	Yes	Yes	0	4	4
218	R:R:C294	R:R:R201	2.79	No	Yes	0	9	4
219	R:R:D209	R:R:I206	13.99	Yes	No	0	4	4
220	R:R:D209	R:R:G207	3.35	Yes	No	0	4	1
221	R:R:D218	R:R:V221	2.92	No	Yes	0	4	4
222	R:R:R225	R:R:V221	6.54	No	Yes	0	8	4
223	R:R:C224	R:R:C294	7.28	No	No	0	9	9
224	R:R:N291	R:R:R225	12.05	No	No	0	6	8
225	R:R:R225	R:R:W295	24.99	No	Yes	0	8	9
226	R:R:V229	R:R:W282	3.68	No	Yes	0	6	9
227	R:R:A283	R:R:V229	3.39	No	No	0	5	6
228	R:R:M231	R:R:Q232	5.44	Yes	No	0	6	7
229	R:R:I235	R:R:M231	2.92	No	Yes	0	5	6
230	R:R:Q232	R:R:W282	6.57	No	Yes	9	7	9
231	R:R:L307	R:R:Q232	6.65	No	No	9	7	7
232	R:R:W272	R:R:Y233	4.82	Yes	Yes	0	9	9
233	R:R:P275	R:R:Y233	4.17	Yes	Yes	0	9	9
234	R:R:V279	R:R:Y233	7.57	No	Yes	0	6	9
235	R:R:P275	R:R:V236	7.07	Yes	Yes	0	9	6
236	R:R:V236	R:R:V279	3.21	Yes	No	0	6	6
237	R:R:L307	R:R:V236	2.98	No	Yes	0	7	6
238	R:R:P310	R:R:V236	3.53	No	Yes	0	9	6
239	R:R:L242	R:R:N238	2.75	No	Yes	0	9	9
240	R:R:V311	R:R:Y239	17.66	No	No	0	8	8
241	R:R:C240	R:R:P275	5.65	No	Yes	0	6	9
242	R:R:G271	R:R:W241	4.22	No	Yes	0	9	9
243	R:R:W241	R:R:W272	20.62	Yes	Yes	0	9	9
244	R:R:L243	R:R:L247	5.54	No	No	0	8	7
245	R:R:A314	R:R:L243	4.73	No	No	0	8	8
246	R:R:I317	R:R:L243	2.85	No	No	0	6	8
247	R:R:V244	R:R:Y267	3.79	No	Yes	0	8	7
248	R:R:E245	R:R:L357	11.93	No	No	0	9	9
249	R:R:G246	R:R:N318	3.39	No	Yes	2	9	9
250	R:R:G246	R:R:I321	3.53	No	Yes	2	9	8
251	R:R:I321	R:R:L247	2.85	Yes	No	0	8	7
252	R:R:Y248	R:R:Y267	5.96	Yes	Yes	0	8	7
253	R:R:L249	R:R:L253	2.77	No	No	2	9	8
254	R:R:I325	R:R:L249	4.28	No	No	2	9	9
255	R:R:H250	R:R:I321	5.3	No	Yes	0	7	8
256	R:R:H250	R:R:R324	6.77	No	No	0	7	8
257	R:R:L255	R:R:N251	5.49	No	No	0	5	7
258	R:R:N251	R:R:Y267	3.49	No	Yes	0	7	7
259	R:R:L252	R:R:P259	3.28	No	No	0	8	6
260	R:R:I325	R:R:L253	5.71	No	No	2	9	8
261	R:R:L253	R:R:L328	4.15	No	No	0	8	8
262	R:R:L258	R:R:P259	3.28	No	No	0	6	6
263	R:R:R261	R:R:S262	3.95	No	No	0	5	5
264	R:R:F263	R:R:R261	6.41	No	No	0	5	5
265	R:R:F263	R:R:Y267	4.13	No	Yes	0	5	7
266	R:R:L268	R:R:W272	6.83	No	Yes	0	5	9
267	R:R:G273	R:R:M276	3.49	No	No	0	6	3
268	R:R:F278	R:R:L277	8.53	No	No	0	5	4
269	R:R:F278	R:R:F309	4.29	No	No	12	5	4
270	R:R:F278	R:R:P310	24.56	No	No	12	5	9
271	R:R:P281	R:R:V280	3.53	No	No	0	4	2
272	R:R:K286	R:R:W282	4.64	Yes	Yes	9	8	9
273	R:R:W282	R:R:W295	3.75	Yes	Yes	9	9	9
274	R:R:L307	R:R:W282	6.83	No	Yes	9	7	9
275	R:R:A283	R:R:W295	3.89	No	Yes	0	5	9
276	R:R:F303	R:R:V285	3.93	Yes	No	0	4	5
277	R:R:K286	R:R:W295	11.6	Yes	Yes	9	8	9
278	R:R:K286	R:R:N298	2.8	Yes	No	0	8	6
279	R:R:F303	R:R:K286	3.72	Yes	Yes	0	4	8
280	R:R:C287	R:R:W295	5.22	No	Yes	0	3	9
281	R:R:F289	R:R:L288	4.87	No	No	0	3	1
282	R:R:E290	R:R:F303	4.66	No	Yes	0	6	4
283	R:R:Q293	R:R:V292	5.73	Yes	No	0	4	4
284	R:R:C294	R:R:T296	3.38	No	Yes	0	9	5
285	R:R:S297	R:R:T296	3.2	No	Yes	3	4	5
286	R:R:N298	R:R:W304	5.65	No	Yes	0	6	6
287	R:R:D299	R:R:N300	6.73	No	No	0	4	5
288	R:R:F303	R:R:N300	8.46	Yes	No	0	4	5
289	R:R:M301	R:R:W304	3.49	No	Yes	0	5	6
290	R:R:F312	R:R:R308	3.21	No	No	0	5	6
291	R:R:F309	R:R:P310	4.33	No	No	12	4	9
292	R:R:I317	R:R:L313	4.28	No	No	0	6	3
293	R:R:I315	R:R:V363	3.07	No	Yes	0	7	6
294	R:R:I321	R:R:N318	2.83	Yes	Yes	2	8	9
295	R:R:L358	R:R:N318	10.98	Yes	Yes	2	9	9
296	R:R:N318	R:R:V360	2.96	Yes	Yes	2	9	6
297	R:R:F319	R:R:V363	3.93	No	Yes	0	7	6
298	R:R:F320	R:R:R324	7.48	No	No	0	5	8
299	R:R:F322	R:R:V326	5.24	Yes	No	0	9	7
300	R:R:F322	R:R:L354	3.65	Yes	No	0	9	9
301	R:R:F322	R:R:I355	6.28	Yes	Yes	2	9	8
302	R:R:F322	R:R:V360	7.87	Yes	Yes	2	9	6
303	R:R:K332	R:R:L328	2.82	No	No	0	9	8
304	R:R:L329	R:R:S350	3	No	No	0	9	9
305	R:R:R334	R:R:V330	3.92	No	No	0	7	6
306	R:R:L333	R:R:Q337	5.32	No	No	0	7	7
307	R:R:L333	R:R:Y343	4.69	No	Yes	0	7	7
308	R:R:R334	R:R:Y343	5.14	No	Yes	0	7	7
309	R:R:H339	R:R:Y343	17.42	No	Yes	0	4	7
310	R:R:K344	R:R:Y343	7.17	No	Yes	0	6	7
311	R:R:F345	R:R:R346	3.21	No	No	0	7	8
312	R:R:K349	R:R:R346	9.9	No	No	0	9	8
313	R:R:R346	R:R:S350	3.95	No	No	0	8	9
314	R:R:I355	R:R:T351	3.04	Yes	No	0	8	9
315	R:R:L399	R:R:T353	8.84	Yes	No	11	8	8
316	R:R:T353	R:R:Y400	3.75	No	Yes	11	8	8
317	R:R:L354	R:R:L358	6.92	No	Yes	0	9	9
318	R:R:I355	R:R:P356	3.39	Yes	No	0	8	9
319	R:R:I355	R:R:V360	4.61	Yes	Yes	2	8	6
320	R:R:H361	R:R:I355	3.98	Yes	Yes	0	8	8
321	R:R:L395	R:R:P356	3.28	No	No	0	6	9
322	R:R:L357	R:R:L358	4.15	No	Yes	0	9	9
323	R:R:L357	R:R:Y400	23.45	No	Yes	0	9	8
324	R:R:L358	R:R:V360	2.98	Yes	Yes	2	9	6
325	R:R:G359	R:R:H361	3.18	No	Yes	0	9	8
326	R:R:E362	R:R:H361	19.69	No	Yes	0	8	8
327	R:R:H361	R:R:Q392	4.95	Yes	No	0	8	9
328	R:R:F367	R:R:V363	5.24	No	Yes	0	5	6
329	R:R:D385	R:R:F365	10.75	Yes	No	0	7	7
330	R:R:F365	R:R:L388	6.09	No	No	0	7	6
331	R:R:S379	R:R:T376	4.8	No	No	0	3	2
332	R:R:A380	R:R:T376	3.36	No	No	0	4	2
333	R:R:L382	R:R:R378	3.64	No	No	0	5	4
334	R:R:K381	R:R:L382	5.64	No	No	0	7	5
335	R:R:D385	R:R:K381	4.15	Yes	No	0	7	7
336	R:R:F383	R:R:F384	5.36	No	No	0	5	4
337	R:R:D385	R:R:L386	2.71	Yes	No	0	7	7
338	R:R:D385	R:R:S389	4.42	Yes	No	0	7	6
339	R:R:F387	R:R:L388	4.87	No	No	0	5	6
340	R:R:F387	R:R:F391	12.86	No	No	0	5	7
341	R:R:F391	R:R:S390	3.96	No	No	0	7	9
342	R:R:L395	R:R:L399	2.77	No	Yes	0	6	8
343	R:R:F402	R:R:V398	5.24	Yes	No	0	9	6
344	R:R:L399	R:R:Y400	5.86	Yes	Yes	11	8	8
345	R:R:C401	R:R:F402	5.59	Yes	Yes	4	9	9
346	R:R:E406	R:R:N404	14.46	No	No	0	9	9
347	R:R:N404	R:R:V407	5.91	No	No	0	9	9
348	R:R:L411	R:R:V407	2.98	No	No	0	5	9
349	R:R:Q408	R:R:R412	3.5	No	No	0	7	5
350	R:R:E410	R:R:R414	9.3	No	No	0	8	5
351	R:R:R413	R:R:R417	3.2	No	No	0	7	7
352	R:R:R414	R:R:R417	8.53	No	No	0	5	7
353	R:R:E55	R:R:L56	2.65	No	No	0	4	2
354	R:R:E410	R:R:L411	2.65	No	No	0	8	5
355	R:R:F230	R:R:S190	2.64	No	No	0	4	5
356	R:R:F264	R:R:S262	2.64	No	No	0	6	5
357	R:R:F319	R:R:V360	2.62	No	Yes	0	7	6
358	R:R:A237	R:R:W272	2.59	No	Yes	0	7	9
359	L:L:E21	L:L:Q17	2.55	No	Yes	0	0	0
360	R:R:F141	R:R:M137	2.49	No	No	0	6	4
361	R:R:F387	R:R:M144	2.49	No	No	0	5	6
362	R:R:V221	R:R:W215	2.45	Yes	No	0	4	2
363	L:L:T29	L:L:W25	2.43	No	Yes	0	0	0
364	R:R:F97	R:R:N78	2.42	No	No	0	5	4
365	R:R:M276	R:R:Y233	2.39	No	Yes	0	3	9
366	R:R:L252	R:R:Y248	2.34	No	Yes	0	8	8
367	R:R:E290	R:R:F289	2.33	No	No	0	6	3
368	R:R:N78	R:R:W68	2.26	No	Yes	0	4	9
369	R:R:G101	R:R:G104	2.11	No	No	0	5	9
370	R:R:G164	R:R:G165	2.11	No	No	0	3	3
371	R:R:G101	R:R:P102	2.03	No	No	0	5	1
372	R:R:R308	R:R:W305	2	No	No	0	6	7
373	R:R:C43	R:R:G40	1.96	Yes	No	0	9	4
374	R:R:P51	R:R:P52	1.95	No	No	0	2	1
375	R:R:P52	R:R:P53	1.95	No	No	0	1	3
376	R:R:A237	R:R:G234	1.95	No	No	0	7	5
377	R:R:A73	R:R:P102	1.87	No	No	0	6	1
378	R:R:A274	R:R:P275	1.87	No	Yes	0	4	9
379	R:R:G148	R:R:V147	1.84	No	No	0	7	5
380	R:R:G223	R:R:V226	1.84	No	No	0	3	4
381	R:R:A155	R:R:A397	1.79	No	No	0	6	8
382	R:R:G271	R:R:I270	1.76	No	No	0	9	7
383	R:R:G154	R:R:L153	1.71	No	No	0	4	6
384	R:R:A220	R:R:S217	1.71	No	No	0	6	4
385	R:R:G269	R:R:L268	1.71	No	No	0	4	5
386	L:L:A19	R:R:V28	1.7	No	No	0	0	3
387	R:R:D195	R:R:G196	1.68	Yes	No	0	7	3
388	R:R:A228	R:R:T296	1.68	No	Yes	0	5	5
389	R:R:L50	R:R:P69	1.64	No	No	0	3	6
390	R:R:N59	R:R:P53	1.63	No	No	0	4	3
391	R:R:S139	R:R:V143	1.62	No	No	0	3	4
392	R:R:S189	R:R:V193	1.62	No	No	0	4	5
393	L:L:A19	R:R:M29	1.61	No	No	0	0	5
394	R:R:V130	R:R:V134	1.6	No	No	0	1	2
395	R:R:V279	R:R:V280	1.6	No	No	0	6	2
396	R:R:V280	R:R:V284	1.6	No	No	0	2	4
397	R:R:V284	R:R:V285	1.6	No	No	0	4	5
398	R:R:V363	R:R:V364	1.6	Yes	No	0	6	6
399	R:R:C224	R:R:L197	1.59	No	No	0	9	4
400	R:R:A178	R:R:L160	1.58	No	No	0	7	6
401	R:R:A178	R:R:L163	1.58	No	Yes	0	7	8
402	L:L:A24	L:L:N28	1.56	No	No	0	0	0
403	R:R:K168	R:R:S167	1.53	Yes	No	0	8	8
404	R:R:I206	R:R:T214	1.52	No	No	0	4	1
405	R:R:G112	R:R:R108	1.5	No	No	0	6	1
406	R:R:G112	R:R:R111	1.5	No	No	0	6	4
407	R:R:L56	R:R:V57	1.49	No	No	0	2	3
408	R:R:L157	R:R:V185	1.49	No	No	0	3	8
409	R:R:L258	R:R:T257	1.47	No	No	0	6	7
410	R:R:I321	R:R:I325	1.47	Yes	No	2	8	9
411	R:R:L347	R:R:T351	1.47	No	No	0	9	9
412	R:R:L352	R:R:T351	1.47	No	No	0	8	9
413	R:R:K332	R:R:L329	1.41	No	No	0	9	9
414	R:R:A175	R:R:F264	1.39	No	No	0	6	6
415	R:R:L333	R:R:L347	1.38	No	No	0	7	9
416	R:R:L399	R:R:L403	1.38	Yes	No	0	8	5
417	L:L:K20	R:R:Q122	1.36	No	No	0	0	3
418	R:R:E260	R:R:L255	1.33	No	No	0	6	5
419	R:R:R199	R:R:S139	1.32	Yes	No	0	4	3
420	R:R:R199	R:R:S203	1.32	Yes	No	0	4	4
421	R:R:R261	R:R:S265	1.32	No	No	0	5	3
422	R:R:D41	R:R:Q42	1.31	No	No	0	4	5
423	R:R:H89	R:R:K90	1.31	No	No	0	5	4
424	R:R:F303	R:R:I306	1.26	Yes	No	0	4	8
425	R:R:F263	R:R:L266	1.22	No	No	0	5	3
426	R:R:N74	R:R:R99	1.21	No	Yes	0	7	3
427	R:R:L377	R:R:R378	1.21	No	No	0	3	4
428	R:R:F95	R:R:H93	1.13	No	No	0	1	4
429	R:R:H416	R:R:W415	1.06	No	No	0	3	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Y10	8.0775	4	5	0
2	L:L:Y13	3.8825	4	0	0
3	L:L:D15	5.685	4	3	0
4	L:L:Q17	3.44	4	0	0
5	L:L:F22	5.38	5	6	0
6	L:L:W25	8.83	5	6	0
7	R:R:Q27	6.992	5	3	5
8	R:R:W36	5.564	5	6	6
9	R:R:Y39	6.554	5	1	6
10	R:R:C43	4.49	4	0	9
11	R:R:Y65	9.57	5	1	6
12	R:R:W68	10.25	5	8	9
13	R:R:T71	5.064	5	8	7
14	R:R:P82	5.844	5	1	8
15	R:R:Y84	10.0325	4	1	5
16	R:R:K98	9.838	5	1	8
17	R:R:R99	5.885	4	7	3
18	R:R:V107	9.4425	4	7	5
19	R:R:W115	9.80833	6	1	4
20	R:R:Q142	7.338	5	5	5
21	R:R:Y145	7.964	5	5	7
22	R:R:Y149	5.792	5	0	8
23	R:R:L156	4.645	4	4	8
24	R:R:L163	2.7475	4	0	8
25	R:R:K168	2.925	4	0	8
26	R:R:F181	3.66667	6	4	8
27	R:R:F184	9.36	5	0	8
28	R:R:D195	5.6925	4	5	7
29	R:R:R199	4.1425	4	5	4
30	R:R:R201	5.836	5	0	4
31	R:R:Y202	7.365	4	0	1
32	R:R:D209	9.16	4	6	4
33	R:R:V221	3.9575	4	0	4
34	R:R:M231	4.09	5	0	6
35	R:R:Y233	4.7375	4	0	9
36	R:R:V236	4.1975	4	0	6
37	R:R:N238	8.0125	4	0	9
38	R:R:W241	9.045	4	0	9
39	R:R:Y248	5.2	5	0	8
40	R:R:Y267	4.3425	4	0	7
41	R:R:W272	8.715	4	0	9
42	R:R:P275	4.69	4	0	9
43	R:R:W282	5.094	5	9	9
44	R:R:K286	5.69	4	9	8
45	R:R:Q293	5.3125	4	3	4
46	R:R:W295	9.89	5	9	9
47	R:R:T296	3.93333	6	3	5
48	R:R:F303	4.406	5	0	4
49	R:R:W304	5.1025	4	0	6
50	R:R:N318	5.04	4	2	9
51	R:R:I321	3.196	5	2	8
52	R:R:F322	5.76	4	2	9
53	R:R:Y343	8.605	4	0	7
54	R:R:I355	4.26	5	2	8
55	R:R:L358	6.2575	4	2	9
56	R:R:V360	4.208	5	2	6
57	R:R:H361	7.95	4	0	8
58	R:R:V363	3.46	4	0	6
59	R:R:D385	5.584	5	0	7
60	R:R:L399	4.7125	4	11	8
61	R:R:Y400	9.8975	4	11	8
62	R:R:C401	3.686	5	4	9
63	R:R:F402	4.3425	4	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I235	R:R:K187	73.6986	2.91	No	No	0	5	8
2	R:R:I235	R:R:M231	74.1829	2.92	No	Yes	0	5	6
3	R:R:M231	R:R:V191	35.2671	3.04	Yes	No	0	6	7
4	R:R:D195	R:R:V191	30.2878	4.38	Yes	No	0	7	7
5	L:L:L14	L:L:Y13	100	3.52	No	Yes	0	0	0
6	L:L:L14	R:R:Y202	41.4859	11.72	No	Yes	0	0	1
7	L:L:L14	L:L:Y10	59.9699	8.21	No	Yes	0	0	0
8	R:R:L198	R:R:Y202	28.035	3.52	No	Yes	0	6	1
9	L:L:Y10	R:R:L198	28.3333	4.69	Yes	No	0	0	6
10	R:R:L198	R:R:T296	54.977	5.9	No	Yes	0	6	5
11	R:R:I194	R:R:M231	56.4473	2.92	No	Yes	0	6	6
12	R:R:I194	R:R:T296	56.7919	3.04	No	Yes	0	6	5
13	R:R:D195	R:R:Q142	28.1777	5.22	Yes	Yes	5	7	5
14	L:L:Y10	R:R:Q142	32.1376	10.15	Yes	Yes	5	0	5
15	L:L:Q17	L:L:Y13	97.792	3.38	Yes	Yes	0	0	0
16	L:L:A18	L:L:E21	93.6689	3.02	No	No	0	0	0
17	L:L:E21	L:L:Q17	94.3702	2.55	No	Yes	0	0	0
18	L:L:A18	R:R:M29	93.3159	3.22	No	No	0	0	5
19	L:L:F22	R:R:M29	92.248	6.22	Yes	No	0	0	5
20	L:L:F22	L:L:W25	45.6173	8.02	Yes	Yes	6	0	0
21	L:L:F22	R:R:W36	43.6264	3.01	Yes	Yes	6	0	6
22	L:L:L26	L:L:W25	41.9178	10.25	No	Yes	0	0	0
23	L:L:L26	R:R:W36	41.4153	4.56	No	Yes	0	0	6
24	L:L:L26	R:R:Y65	82.3129	5.86	No	Yes	0	0	6
25	R:R:W115	R:R:Y65	49.6668	10.61	Yes	Yes	1	4	6
26	R:R:Y65	R:R:Y84	23.077	9.93	Yes	Yes	1	6	5
27	R:R:Y39	R:R:Y84	14.7724	5.96	Yes	Yes	1	6	5
28	R:R:K98	R:R:W115	45.6993	4.64	Yes	Yes	1	8	4
29	R:R:I79	R:R:K98	30.3296	17.45	No	Yes	0	4	8
30	R:R:I79	R:R:W68	29.3094	18.79	No	Yes	0	4	9
31	R:R:P69	R:R:W68	10.6637	17.57	No	Yes	0	6	9
32	R:R:K98	R:R:R116	11.5161	16.09	Yes	No	0	8	6
33	R:R:C100	R:R:R116	10.4785	5.57	No	No	0	9	6
34	R:R:N78	R:R:W68	13.8334	2.26	No	Yes	0	4	9
35	R:R:F97	R:R:N78	12.7784	2.42	No	No	0	5	4
36	R:R:F97	R:R:T76	11.7218	6.49	No	No	0	5	5
37	R:R:R99	R:R:T76	10.6637	7.76	Yes	No	0	3	5
38	R:R:K187	R:R:N238	73.014	6.99	No	Yes	0	8	9
39	R:R:F184	R:R:N238	71.5589	19.33	Yes	Yes	0	8	9
40	R:R:F184	R:R:L156	22.6102	4.87	Yes	Yes	0	8	8
41	R:R:F181	R:R:L156	19.4253	6.09	Yes	Yes	4	8	8
42	R:R:C401	R:R:F181	14.9431	2.79	Yes	Yes	4	9	8
43	R:R:C401	R:R:L163	11.8228	3.17	Yes	Yes	0	9	8
44	R:R:F184	R:R:Q392	48.403	11.71	Yes	No	0	8	9
45	R:R:H361	R:R:Q392	47.8216	4.95	Yes	No	0	8	9
46	R:R:H361	R:R:I355	46.0727	3.98	Yes	Yes	0	8	8
47	R:R:I355	R:R:V360	33.1995	4.61	Yes	Yes	2	8	6
48	R:R:L358	R:R:V360	15.9823	2.98	Yes	Yes	2	9	6
49	R:R:L357	R:R:L358	16.1166	4.15	No	Yes	0	9	9
50	R:R:E245	R:R:L357	14.2441	11.93	No	No	0	9	9
51	R:R:E245	R:R:I176	13.1374	4.1	No	No	0	9	9
52	R:R:I176	R:R:Y248	12.5074	4.84	No	Yes	0	9	8
53	R:R:L307	R:R:V236	20.2336	2.98	No	Yes	0	7	6
54	R:R:N318	R:R:V360	13.6915	2.96	Yes	Yes	2	9	6
55	R:R:I321	R:R:N318	13.0364	2.83	Yes	Yes	2	8	9
56	R:R:M231	R:R:Q232	19.2666	5.44	Yes	No	0	6	7
57	R:R:L307	R:R:Q232	15.6627	6.65	No	No	9	7	7
58	R:R:R201	R:R:Y202	10.1673	6.17	Yes	Yes	0	4	1

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:H1	R:R:W304	8.46	0	No	Yes	0	6	0	1
L:L:H1	R:R:R308	18.05	0	No	No	0	6	0	1
L:L:H1	R:R:V311	12.45	0	No	No	0	8	0	1
L:L:S2	R:R:D385	5.89	0	No	Yes	0	7	0	1
L:L:G4	R:R:W304	2.81	0	No	Yes	0	6	0	1
L:L:F6	R:R:Y145	7.22	0	No	Yes	0	7	0	1
L:L:F6	R:R:L386	3.65	0	No	No	0	7	0	1
L:L:S8	R:R:N298	8.94	0	No	No	0	6	0	1
L:L:D9	R:R:Y138	8.05	0	No	No	0	5	0	1
L:L:Y10	R:R:Q142	10.15	5	Yes	Yes	0	5	0	1
L:L:Y10	R:R:L198	4.69	5	Yes	No	0	6	0	1
L:L:Y10	R:R:R199	9.26	5	Yes	Yes	0	4	0	1
L:L:S11	R:R:T296	6.4	3	No	Yes	0	5	0	1
L:L:S11	R:R:S297	6.52	3	No	No	0	4	0	1
L:L:K12	R:R:Q27	5.42	0	No	Yes	0	5	0	1
L:L:Y13	R:R:A135	2.67	0	Yes	No	0	3	0	1
L:L:Y13	R:R:Y138	5.96	0	Yes	No	0	5	0	1
L:L:L14	R:R:Y202	11.72	0	No	Yes	0	1	0	1
L:L:D15	R:R:Q27	7.83	3	Yes	Yes	0	5	0	1
L:L:D15	R:R:Y202	8.05	3	Yes	Yes	0	1	0	1
L:L:D15	R:R:Q293	3.92	3	Yes	Yes	0	4	0	1
L:L:E16	R:R:W87	5.45	0	No	No	0	3	0	1
L:L:Q17	R:R:Q131	5.12	0	Yes	No	0	3	0	1
L:L:A18	R:R:M29	3.22	0	No	No	0	5	0	1
L:L:E21	R:R:K205	12.15	0	No	No	0	4	0	1
L:L:F22	R:R:M29	6.22	6	Yes	No	0	5	0	1
L:L:F22	R:R:L32	4.87	6	Yes	No	0	4	0	1
L:L:F22	R:R:W36	3.01	6	Yes	Yes	0	6	0	1
L:L:F22	R:R:D209	4.78	6	Yes	Yes	0	4	0	1
L:L:I23	R:R:W87	4.7	0	No	No	0	3	0	1
L:L:W25	R:R:D208	8.93	6	Yes	No	0	4	0	1
L:L:W25	R:R:D209	14.52	6	Yes	Yes	0	4	0	1
L:L:L26	R:R:W36	4.56	0	No	Yes	0	6	0	1
L:L:L26	R:R:Y65	5.86	0	No	Yes	0	6	0	1
L:L:M27	R:R:Y65	16.76	1	No	Yes	0	6	0	1
L:L:M27	R:R:W115	8.14	1	No	Yes	0	4	0	1
L:L:M27	R:R:S119	6.13	1	No	No	0	5	0	1
L:L:T29	R:R:R111	3.88	0	No	No	0	4	0	1
R:R:D30	R:R:Q27	3.92	3	No	Yes	5	5	2	1
R:R:Q27	R:R:Q293	7.68	3	Yes	Yes	5	4	1	1
R:R:Q27	R:R:S297	10.11	3	Yes	No	5	4	1	1
R:R:D30	R:R:Q293	3.92	3	No	Yes	5	4	2	1
R:R:L32	R:R:P86	9.85	0	No	No	4	3	1	2
R:R:F33	R:R:W36	4.01	6	No	Yes	4	6	2	1
R:R:F33	R:R:K37	12.41	6	No	No	4	3	2	2
R:R:K37	R:R:W36	3.48	6	No	Yes	3	6	2	1
R:R:K64	R:R:W36	12.76	0	No	Yes	4	6	2	1
R:R:D63	R:R:T61	14.45	1	No	No	9	6	2	2
R:R:T61	R:R:W115	3.64	1	No	Yes	6	4	2	1
R:R:D63	R:R:W115	14.52	1	No	Yes	9	4	2	1
R:R:Y65	R:R:Y84	9.93	1	Yes	Yes	6	5	1	2
R:R:L85	R:R:Y65	4.69	1	No	Yes	6	6	2	1
R:R:W115	R:R:Y65	10.61	1	Yes	Yes	4	6	1	1
R:R:K98	R:R:S66	4.59	1	Yes	No	8	5	2	2
R:R:S66	R:R:W115	17.3	1	No	Yes	5	4	2	1
R:R:L85	R:R:Y84	11.72	1	No	Yes	6	5	2	2
R:R:M123	R:R:W87	12.8	0	No	No	3	3	2	1
R:R:K98	R:R:W115	4.64	1	Yes	Yes	8	4	2	1
R:R:P110	R:R:R111	5.76	0	No	No	3	4	2	1
R:R:I128	R:R:Q131	6.86	0	No	No	2	3	2	1
R:R:K132	R:R:Q131	4.07	0	No	No	2	3	2	1
R:R:M137	R:R:Y138	3.59	0	No	No	4	5	2	1
R:R:Q142	R:R:Y145	12.4	5	Yes	Yes	5	7	1	1
R:R:Q142	R:R:T146	4.25	5	Yes	No	5	7	1	2
R:R:D195	R:R:Q142	5.22	5	Yes	Yes	7	5	2	1
R:R:Q142	R:R:R199	4.67	5	Yes	Yes	5	4	1	1
R:R:T146	R:R:Y145	3.75	5	No	Yes	7	7	2	1
R:R:Y145	R:R:Y149	4.96	5	Yes	Yes	7	8	1	2
R:R:D195	R:R:Y145	11.49	5	Yes	Yes	7	7	2	1
R:R:I194	R:R:T296	3.04	0	No	Yes	6	5	2	1
R:R:L198	R:R:Y202	3.52	0	No	Yes	6	1	1	1
R:R:L198	R:R:T296	5.9	0	No	Yes	6	5	1	1
R:R:R201	R:R:Y202	6.17	0	Yes	Yes	4	1	2	1
R:R:C294	R:R:R201	2.79	0	No	Yes	9	4	2	2
R:R:D209	R:R:I206	13.99	6	Yes	No	4	4	1	2
R:R:D209	R:R:G207	3.35	6	Yes	No	4	1	1	2
R:R:V311	R:R:Y239	17.66	0	No	No	8	8	1	2
R:R:K286	R:R:N298	2.8	9	Yes	No	8	6	2	1
R:R:Q293	R:R:V292	5.73	3	Yes	No	4	4	1	2
R:R:C294	R:R:T296	3.38	0	No	Yes	9	5	2	1
R:R:S297	R:R:T296	3.2	3	No	Yes	4	5	1	1
R:R:N298	R:R:W304	5.65	0	No	Yes	6	6	1	1
R:R:M301	R:R:W304	3.49	0	No	Yes	5	6	2	1
R:R:F312	R:R:R308	3.21	0	No	No	5	6	2	1
R:R:D385	R:R:F365	10.75	0	Yes	No	7	7	1	2
R:R:D385	R:R:K381	4.15	0	Yes	No	7	7	1	2
R:R:D385	R:R:L386	2.71	0	Yes	No	7	7	1	1
R:R:D385	R:R:S389	4.42	0	Yes	No	7	6	1	2
R:R:R308	R:R:W305	2	0	No	No	6	7	1	2
L:L:A19	R:R:V28	1.7	0	No	No	0	3	0	1
R:R:A228	R:R:T296	1.68	0	No	Yes	5	5	2	1
L:L:A19	R:R:M29	1.61	0	No	No	0	5	0	1
R:R:G112	R:R:R111	1.5	0	No	No	6	4	2	1
L:L:K20	R:R:Q122	1.36	0	No	No	0	3	0	1
R:R:R199	R:R:S139	1.32	5	Yes	No	4	3	1	2
R:R:R199	R:R:S203	1.32	5	Yes	No	4	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JIQ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.67
Number of Linked Nodes	378
Number of Links	429
Number of Hubs	63
Number of Links mediated by Hubs	233
Number of Communities	12
Number of Nodes involved in Communities	73
Number of Links involved in Communities	95

Path Summary
Number Of Nodes in MetaPath	59
Number Of Links MetaPath	58
Number of Shortest Paths	183829
Length Of Smallest Path	3
Average Path Length	22.4196
Length of Longest Path	47
Minimum Path Strength	1.32
Average Path Strength	5.8895
Maximum Path Strength	18.52
Minimum Path Correlation	0.7
Average Path Correlation	0.957423
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	51.0631
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.105
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • glucagon receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • amide binding • peptide hormone binding • hormone binding • enzyme regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • GDP binding • purine ribonucleotide binding • ion binding • anion binding • molecular function regulator activity • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • nucleoside-triphosphatase regulator activity • GTPase regulator activity • purine ribonucleoside triphosphate binding • guanyl-nucleotide exchange factor activity • nucleoside phosphate binding • purine nucleotide binding • small molecule binding • circulatory system process • regulation of blood pressure • blood circulation • regulation of biosynthetic process • positive regulation of biological process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • hormone-mediated signaling pathway • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • carbohydrate metabolic process • energy derivation by oxidation of organic compounds • glycogen metabolic process • primary metabolic process • regulation of generation of precursor metabolites and energy • generation of precursor metabolites and energy • regulation of polysaccharide metabolic process • regulation of primary metabolic process • glucan metabolic process • polysaccharide metabolic process • energy reserve metabolic process • regulation of glycogen metabolic process • regulation of carbohydrate metabolic process • cellular response to nutrient levels • response to nutrient levels • response to starvation • cellular response to starvation • cell surface receptor signaling pathway • response to nutrient • localization • secretion by cell • exocytosis • transport • secretion • export from cell • establishment of localization • vesicle-mediated transport • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • endosome • intracellular vesicle • cytoplasmic vesicle
SCOP2	Domain Identifier	• G protein-coupled receptor-like • FnI-like domain
SCOP2	Family Identifier	• G protein-coupled receptor-like • FnI-like domain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P47871
Sequence	>8JIQ_nogp_Chain_R Q V M D F L F E K W K L Y G D Q C H H N L S L L P P P T E L V C N R T F D K Y S C W P D T P A N T T A N I S C P W Y L P W H H K V Q H R F V F K R C G P D G Q W V R G P R G Q P W R D A S Q C Q M D G E E I E V Q K E V A K M Y S S F Q V M Y T V G Y S L S L G A L L L A L A I L G G L S K L H C T R N A I H A N L F A S F V L K A S S V L V I D G L L R T R Y S Q K I G D D T W L S D G A V A G C R V A A V F M Q Y G I V A N Y C W L L V E G L Y L H N L L G L A T L P E R S F F S L Y L G I G W G A P M L F V V P W A V V K C L F E N V Q C W T S N D N M G F W W I L R F P V F L A I L I N F F I F V R I V Q L L V A K L R A R Q M H Y K F R L A K S T L T L I P L L G V H E V V F A F V G T L R S A K L F F D L F L S S F Q G L L V A V L Y C F L N K E V Q S E L R R R W H R W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9IVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839	chim(NtGi1-Gs)/β2/γ2	3.22	2024-11-13	10.1016/j.apsb.2024.09.002
	9IVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839		3.22	2024-11-13	10.1016/j.apsb.2024.09.002
	8YW4	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ22	3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW4 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-		3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW5	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.84	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW5 (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Retatrutide	-		2.84	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8WG8	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	Peptide	chim(NtGi1-Gs)/β1/γ2	2.71	2024-03-06	10.1038/s41421-024-00649-0
	8WG8 (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	Peptide		2.71	2024-03-06	10.1038/s41421-024-00649-0
	8WA3	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	2.86	2024-03-06	10.1038/s41421-024-00649-0
	8WA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		2.86	2024-03-06	10.1038/s41421-024-00649-0
	8WG7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.54	2024-03-06	10.1038/s41421-024-00649-0
	8WG7 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.54	2024-03-06	10.1038/s41421-024-00649-0
	8JIS	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-	chim(NtGi1-Gs)/β1/γ2	2.46	2023-11-08	10.1073/pnas.2303696120
	8JIS (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-		2.46	2023-11-08	10.1073/pnas.2303696120
	8ITM	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.13	2023-10-18	10.1073/pnas.2306145120
	8ITM (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.13	2023-10-18	10.1073/pnas.2306145120
	8ITL	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.23	2023-10-18	10.1073/pnas.2306145120
	8ITL (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.23	2023-10-18	10.1073/pnas.2306145120
	8JIR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-	chim(NtGi1-Gs)/β1/γ2	2.57	2023-09-06	10.1073/pnas.2303696120
	8JIR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-		2.57	2023-09-06	10.1073/pnas.2303696120
	8JIP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-	chim(NtGi1-Gs)/β1/γ2	2.85	2023-09-06	10.1073/pnas.2303696120
	8JIP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-		2.85	2023-09-06	10.1073/pnas.2303696120
	8JIT	B1	Peptide	Glucagon	Glucagon	Homo sapiens	MEDI0382	-	Gs/β1/γ2	2.91	2023-09-06	10.1073/pnas.2303696120
	8JIT (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	MEDI0382	-		2.91	2023-09-06	10.1073/pnas.2303696120
	8JRV	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-	Arrestin2	3.3	2023-08-16	10.1038/s41586-023-06420-x
	8JRU	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	-	Arrestin2	3.5	2023-08-16	10.1038/s41586-023-06420-x
	8FU6	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon derivative ZP3780	-	Gs/β1/γ2	2.9	2023-04-12	10.1016/j.cell.2023.02.028
	8FU6 (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon derivative ZP3780	-		2.9	2023-04-12	10.1016/j.cell.2023.02.028
	9IVG	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	chim(NtGi1-Gs)/β1/γ2	3	2024-11-27	10.1016/j.apsb.2024.09.002
	9IVG (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-		3	2024-11-27	10.1016/j.apsb.2024.09.002
	9J1P	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-	chim(NtGi1-Gs)/β1/γ2	2.99	2025-02-26	10.1021/jacs.4c12808
	9J1P (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-		2.99	2025-02-26	10.1021/jacs.4c12808
	8JIU	B1	Peptide	Glucagon	Glucagon	Homo sapiens	SAR425899	-	Gs/β1/γ2	2.76	2023-09-13	10.1073/pnas.2303696120
	8JIU (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	SAR425899	-		2.76	2023-09-13	10.1073/pnas.2303696120
	8JIQ	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-15	-	Gs/β1/γ2	3.4	2023-09-13	10.1073/pnas.2303696120
	8JIQ (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-15	-		3.4	2023-09-13	10.1073/pnas.2303696120
	7X8S	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-	Gs/β1/γ2	3.09	2022-06-29	10.1073/pnas.2200155119
	7X8S (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-		3.09	2022-06-29	10.1073/pnas.2200155119
	7X8R	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-	Gs/β1/γ2	2.61	2022-06-29	10.1073/pnas.2200155119
	7X8R (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-		2.61	2022-06-29	10.1073/pnas.2200155119
	7S15	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 134611223	-	-	3.8	2022-06-08	10.1021/acs.jmedchem.1c01856
	7RBT	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	PubChem 163183774	chim(NtGi1-Gs)/β1/γ2	3.08	2022-04-13	10.1073/pnas.2116506119
	7RBT (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	PubChem 163183774		3.08	2022-04-13	10.1073/pnas.2116506119
	7RA3	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	chim(NtGi1-Gs)/β1/γ2	3.24	2022-04-13	10.1073/pnas.2116506119
	7RA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		3.24	2022-04-13	10.1073/pnas.2116506119
	7RGP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2022-04-13	10.1073/pnas.2116506119
	7RGP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		2.9	2022-04-13	10.1073/pnas.2116506119
	7RG9	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-04-13	10.1073/pnas.2116506119
	7RG9 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.2	2022-04-13	10.1073/pnas.2116506119
	7V9L	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2022-04-06	10.1073/pnas.2106606118
	7V9L (No Gprot)	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	-	-		2.6	2022-04-06	10.1073/pnas.2106606118
	7VBH	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3	2022-04-06	10.1038/s41467-022-28683-0
	7VBH (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-		3	2022-04-06	10.1038/s41467-022-28683-0
	7VAB	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-03-02	10.1038/s41467-022-28683-0
	7VAB (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-		3.2	2022-03-02	10.1038/s41467-022-28683-0
	7FIY	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	10.1038/s41467-022-28683-0
	7FIY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	10.1038/s41467-022-28683-0
	7VBI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-	Gs/β1/γ2	3	2022-03-02	10.1038/s41467-022-28683-0
	7VBI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-		3	2022-03-02	10.1038/s41467-022-28683-0
	7FIM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	10.1038/s41467-022-28683-0
	7FIM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	10.1038/s41467-022-28683-0
	7V35	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3.5	2022-03-02	10.1038/s41467-022-28683-0
	7V35 (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-20	-		3.5	2022-03-02	10.1038/s41467-022-28683-0
	7FIN	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-	Gs/β1/γ2	3.1	2022-02-23	10.1038/s41467-022-28683-0
	7FIN (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-		3.1	2022-02-23	10.1038/s41467-022-28683-0
	7LLY	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-	Gs/β1/γ2	3.3	2022-01-12	10.1038/s41467-021-27760-0
	7LLY (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-		3.3	2022-01-12	10.1038/s41467-021-27760-0
	7LLL	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	3.7	2022-01-12	10.1038/s41467-021-27760-0
	7LLL (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		3.7	2022-01-12	10.1038/s41467-021-27760-0
	7S3I	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.51	2022-01-05	10.1038/s41589-021-00945-w
	7S3I (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.51	2022-01-05	10.1038/s41589-021-00945-w
	7S1M	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-	Gs/β1/γ2	2.41	2022-01-05	10.1038/s41589-021-00945-w
	7S1M (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-		2.41	2022-01-05	10.1038/s41589-021-00945-w
	7V9M	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	Somatoliberin	-	Gs/β1/γ2	3.29	2021-10-20	10.1073/pnas.2106606118
	7V9M (No Gprot)	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	Somatoliberin	-		3.29	2021-10-20	10.1073/pnas.2106606118
	7RTB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-	Gs/β1/γ2	2.14	2021-10-06	10.1016/j.bbrc.2021.09.016
	7RTB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-		2.14	2021-10-06	10.1016/j.bbrc.2021.09.016
	7EVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	2.5	2021-08-11	10.1038/s41467-021-24058-z
	7EVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		2.5	2021-08-11	10.1038/s41467-021-24058-z
	7DUR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	3.3	2021-08-11	10.1038/s41467-021-24058-z
	7DUR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		3.3	2021-08-11	10.1038/s41467-021-24058-z
	7DTY	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	Gs/β1/γ2	2.98	2021-08-04	10.7554/eLife.68719
	7DTY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		2.98	2021-08-04	10.7554/eLife.68719
	7KI1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-	Gs/β1/γ2	2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI1 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-		2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI0	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-	Gs/β1/γ2	2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI0 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-		2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7DUQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738	Gs/β1/γ2	2.5	2021-07-14	10.1038/s41467-021-24058-z
	7DUQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738		2.5	2021-07-14	10.1038/s41467-021-24058-z
	7E14	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738	Gs/β1/γ2	2.9	2021-07-07	10.1038/s41467-021-24058-z
	7E14 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738		2.9	2021-07-07	10.1038/s41467-021-24058-z
	7LCK	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	3.24	2021-01-20	10.1016/j.str.2021.04.008
	7LCJ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	2.82	2021-01-20	10.1016/j.str.2021.04.008
	7LCI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.9	2021-01-20	10.1016/j.str.2021.04.008
	7LCI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.9	2021-01-20	10.1016/j.str.2021.04.008
	7D68	B1	Peptide	Glucagon	GLP-2	Homo sapiens	GLP-2	-	Gs/β1/γ2	3	2020-12-16	10.1038/s41422-020-00442-0
	7D68 (No Gprot)	B1	Peptide	Glucagon	GLP-2	Homo sapiens	GLP-2	-		3	2020-12-16	10.1038/s41422-020-00442-0
	6XOX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-	chim(NtGi1-Gs)/β1/γ2	3.1	2020-11-18	10.1073/pnas.2014879117
	6XOX (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-		3.1	2020-11-18	10.1073/pnas.2014879117
	7CZ5	B1	Peptide	Glucagon	GHRH	Homo sapiens	Somatoliberin	-	Gs/β1/γ2	2.6	2020-11-18	10.1038/s41467-020-18945-0
	7CZ5 (No Gprot)	B1	Peptide	Glucagon	GHRH	Homo sapiens	Somatoliberin	-		2.6	2020-11-18	10.1038/s41467-020-18945-0
	7D3S	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	2.9	2020-11-04	10.1016/j.bbrc.2020.08.042
	7D3S (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		2.9	2020-11-04	10.1016/j.bbrc.2020.08.042
	6X1A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.5	2020-09-09	10.1016/j.molcel.2020.09.020
	6X1A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.5	2020-09-09	10.1016/j.molcel.2020.09.020
	6X19	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-	Gs/β1/γ2	2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X19 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-		2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X18	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X18 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	7C2E	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-	Gs/β1/γ2	4.2	2020-08-26	10.1038/s41422-020-0384-8
	7C2E (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-		4.2	2020-08-26	10.1038/s41422-020-0384-8
	6WPW	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon derivative ZP3780	-	Gs/β1/γ2	3.1	2020-08-12	10.1126/science.aba3373
	6WPW (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon derivative ZP3780	-		3.1	2020-08-12	10.1126/science.aba3373
	6WZG	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	2.3	2020-08-12	10.1038/s41467-020-17791-4
	6WZG (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		2.3	2020-08-12	10.1038/s41467-020-17791-4
	6WI9	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	4.3	2020-08-12	10.1038/s41467-020-17791-4
	6WI9 (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		4.3	2020-08-12	10.1038/s41467-020-17791-4
	6VCB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440	Gs/β1/γ2	3.3	2020-07-22	10.1038/s41589-020-0589-7
	6VCB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440		3.3	2020-07-22	10.1038/s41589-020-0589-7
	6WHC	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glu16 analog of GCG	-	Gs/β1/γ2	3.4	2020-05-27	10.1074/jbc.RA120.013793
	6WHC (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glu16 analog of GCG	-		3.4	2020-05-27	10.1074/jbc.RA120.013793
	6LML	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-	Gi1/β1/γ1	3.9	2020-04-01	10.1126/science.aaz5346
	6LML (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-		3.9	2020-04-01	10.1126/science.aaz5346
	6LMK	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-	Gs/β1/γ2	3.7	2020-04-01	10.1126/science.aaz5346
	6LMK (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-		3.7	2020-04-01	10.1126/science.aaz5346
	6LN2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	3.2	2020-03-18	10.1038/s41467-020-14934-5
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	10.1038/s41586-019-1902-z
	6KK7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	3.1	2019-11-13	10.1107/S2052252519013496
	6KK1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	2.8	2019-11-13	10.1107/S2052252519013496
	6KJV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	2.8	2019-11-13	10.1107/S2052252519013496
	6B3J	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-	Gs/β1/γ2	3.3	2018-02-21	10.1038/nature25773
	6B3J (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-		3.3	2018-02-21	10.1038/nature25773
	5YQZ	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon analogue	-	-	3	2018-01-17	10.1038/nature25153
	5NX2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	-	3.7	2017-06-14	10.1038/nature22800
	5VEW	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.7	2017-05-24	10.1038/nature22378
	5XF1	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	NNC0640	-	3.19	2017-05-24	10.1038/nature22363
	5XEZ	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	NNC0640	-	3	2017-05-24	10.1038/nature22363
	5VAI	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-	Gs/β1/γ2	4.1	2017-05-24	10.1038/nature22394
	5VAI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-		4.1	2017-05-24	10.1038/nature22394
	5VEX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	NNC0640	-	3	2017-05-17	10.1038/nature22378
	5EE7	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	MK0893	-	2.5	2016-04-20	10.1038/nature17414
	4L6R	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	-	-	3.3	2013-07-24	10.1038/nature12393

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