psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:H1	R:R:L267	3.86	Yes	Yes	1	0	6
2	L:L:H1	R:R:H268	15.53	Yes	Yes	1	0	7
3	L:L:H1	R:R:V271	13.84	Yes	No	0	0	6
4	L:L:H1	R:R:W340	8.46	Yes	Yes	1	0	6
5	L:L:A2	R:R:Q421	4.55	No	No	0	0	8
6	L:L:D3	R:R:Y186	6.9	No	Yes	1	0	7
7	L:L:D3	R:R:V228	8.76	No	Yes	1	0	7
8	L:L:G4	L:L:S7	3.71	No	Yes	0	0	0
9	L:L:F6	L:L:M10	4.98	Yes	No	1	0	0
10	L:L:F6	R:R:L175	3.65	Yes	No	0	0	5
11	L:L:F6	R:R:L178	4.87	Yes	No	1	0	5
12	L:L:F6	R:R:Q179	4.68	Yes	Yes	1	0	5
13	L:L:F6	R:R:Y182	12.38	Yes	Yes	1	0	7
14	L:L:F6	R:R:L422	3.65	Yes	No	1	0	7
15	L:L:N11	L:L:S7	2.98	Yes	Yes	1	0	0
16	L:L:S7	R:R:K231	4.59	Yes	Yes	1	0	7
17	L:L:S7	R:R:T332	3.2	Yes	No	1	0	6
18	L:L:D8	R:R:T333	2.89	No	No	0	0	4
19	L:L:D8	R:R:N334	4.04	No	No	0	0	7
20	L:L:E9	R:R:K414	6.75	No	No	0	0	5
21	L:L:M10	R:R:Y172	4.79	No	Yes	0	0	1
22	L:L:M10	R:R:Q179	8.16	No	Yes	1	0	5
23	L:L:N11	R:R:F235	13.29	Yes	Yes	1	0	8
24	L:L:N11	R:R:Y239	3.49	Yes	Yes	0	0	4
25	L:L:N11	R:R:T332	11.7	Yes	No	1	0	6
26	L:L:I13	R:R:R171	3.76	No	No	0	0	4
27	L:L:I13	R:R:Y172	3.63	No	Yes	0	0	1
28	L:L:L14	R:R:Y172	4.69	No	Yes	0	0	1
29	L:L:L14	R:R:Y239	7.03	No	Yes	0	0	4
30	L:L:N16	R:R:N168	8.17	No	Yes	0	0	3
31	L:L:A18	R:R:R242	4.15	No	No	0	0	2
32	L:L:R20	R:R:F165	3.21	No	No	0	0	1
33	L:L:D21	R:R:R242	19.06	No	No	0	0	2
34	L:L:F22	L:L:I23	3.77	Yes	No	0	0	0
35	L:L:F22	L:L:W25	4.01	Yes	Yes	3	0	0
36	L:L:F22	L:L:L26	4.87	Yes	No	3	0	0
37	L:L:F22	R:R:W249	20.04	Yes	Yes	3	0	3
38	L:L:L26	L:L:W25	5.69	No	Yes	3	0	0
39	L:L:T29	L:L:W25	6.06	No	Yes	0	0	0
40	L:L:W25	R:R:D244	5.58	Yes	No	0	0	1
41	L:L:W25	R:R:N247	3.39	Yes	No	0	0	4
42	L:L:W25	R:R:W249	15.93	Yes	Yes	3	0	3
43	R:R:F165	R:R:N168	4.83	No	Yes	0	1	3
44	R:R:D170	R:R:K166	6.91	No	No	0	1	3
45	R:R:N168	R:R:Q167	3.96	Yes	No	0	3	3
46	R:R:L415	R:R:R171	4.86	Yes	No	0	4	4
47	R:R:Y172	R:R:Y236	3.97	Yes	No	0	1	4
48	R:R:L174	R:R:L415	5.54	No	Yes	0	4	4
49	R:R:F419	R:R:L178	10.96	No	No	0	6	5
50	R:R:L178	R:R:L422	5.54	No	No	1	5	7
51	R:R:Q179	R:R:Y182	4.51	Yes	Yes	1	5	7
52	R:R:D232	R:R:Q179	6.53	No	Yes	1	8	5
53	R:R:Y182	R:R:Y186	5.96	Yes	Yes	1	7	7
54	R:R:D232	R:R:Y182	5.75	No	Yes	1	8	7
55	R:R:L422	R:R:Y182	3.52	No	Yes	1	7	7
56	R:R:L229	R:R:T183	2.95	No	No	0	7	7
57	R:R:G185	R:R:S426	3.71	No	No	0	8	9
58	R:R:F427	R:R:G185	4.52	No	No	0	8	8
59	R:R:R224	R:R:Y186	7.2	Yes	Yes	1	8	7
60	R:R:T225	R:R:Y186	8.74	No	Yes	0	8	7
61	R:R:V228	R:R:Y186	6.31	Yes	Yes	1	7	7
62	R:R:S425	R:R:Y186	3.82	No	Yes	1	6	7
63	R:R:S426	R:R:Y186	5.09	No	Yes	0	9	7
64	R:R:F188	R:R:F427	3.22	No	No	0	4	8
65	R:R:F194	R:R:L190	4.87	No	No	5	4	7
66	R:R:I222	R:R:L190	4.28	Yes	No	5	7	7
67	R:R:L190	R:R:T225	7.37	No	No	0	7	8
68	R:R:F430	R:R:S192	5.28	No	No	0	7	6
69	R:R:F218	R:R:L193	3.65	Yes	Yes	0	9	9
70	R:R:F221	R:R:L193	7.31	Yes	Yes	0	8	9
71	R:R:I222	R:R:L193	4.28	Yes	Yes	0	7	9
72	R:R:A433	R:R:L193	3.15	No	Yes	0	8	9
73	R:R:F194	R:R:I222	13.82	No	Yes	5	4	7
74	R:R:F218	R:R:L200	3.65	Yes	No	0	9	8
75	R:R:L201	R:R:M215	4.24	No	No	0	3	6
76	R:R:F202	R:R:L203	3.65	No	No	0	3	8
77	R:R:L203	R:R:L206	11.07	No	Yes	2	8	9
78	R:R:H207	R:R:R204	5.64	No	No	0	7	8
79	R:R:K205	R:R:L206	5.64	No	Yes	2	7	9
80	R:R:E446	R:R:K205	18.9	No	No	2	8	7
81	R:R:E442	R:R:L206	15.9	No	Yes	0	9	9
82	R:R:E446	R:R:L206	3.98	No	Yes	2	8	9
83	R:R:H207	R:R:Y212	13.07	No	No	0	7	6
84	R:R:C208	R:R:R210	4.18	No	Yes	2	8	9
85	R:R:C208	R:R:N211	3.15	No	No	2	8	9
86	R:R:C208	R:R:E296	3.04	No	No	0	8	7
87	R:R:I213	R:R:T209	3.04	No	No	2	9	7
88	R:R:T209	R:R:Y284	8.74	No	Yes	2	7	9
89	R:R:N211	R:R:R210	8.44	No	Yes	2	9	9
90	R:R:H214	R:R:R210	4.51	No	Yes	0	9	9
91	R:R:R210	R:R:Y284	5.14	Yes	Yes	2	9	9
92	R:R:M215	R:R:Y212	3.59	No	No	0	6	6
93	R:R:L299	R:R:Y212	3.52	No	No	0	4	6
94	R:R:E281	R:R:I213	6.83	Yes	No	0	9	9
95	R:R:I213	R:R:Y284	4.84	No	Yes	2	9	9
96	R:R:E281	R:R:H214	12.31	Yes	No	0	9	9
97	R:R:H214	R:R:Y436	8.71	No	No	0	9	8
98	R:R:N216	R:R:W277	18.08	No	Yes	6	9	9
99	R:R:N216	R:R:W308	6.78	No	Yes	6	9	9
100	R:R:F221	R:R:L217	4.87	Yes	No	0	8	9
101	R:R:L217	R:R:L278	5.54	No	No	0	9	9
102	R:R:E281	R:R:L217	5.3	Yes	No	0	9	9
103	R:R:F218	R:R:V432	3.93	Yes	No	0	9	9
104	R:R:N274	R:R:S220	5.96	No	No	0	9	9
105	R:R:S220	R:R:W308	3.71	No	Yes	0	9	9
106	R:R:F221	R:R:R224	3.21	Yes	Yes	1	8	8
107	R:R:F221	R:R:N274	15.71	Yes	No	1	8	9
108	R:R:F221	R:R:H428	9.05	Yes	Yes	0	8	9
109	R:R:F221	R:R:G429	9.03	Yes	No	0	8	9
110	R:R:F221	R:R:V432	3.93	Yes	No	0	8	9
111	R:R:F270	R:R:L223	9.74	Yes	No	0	5	7
112	R:R:R224	R:R:V271	3.92	Yes	No	0	8	6
113	R:R:N274	R:R:R224	7.23	No	Yes	1	9	8
114	R:R:R224	R:R:S425	3.95	Yes	No	1	8	6
115	R:R:A227	R:R:F270	5.55	No	Yes	0	6	5
116	R:R:K231	R:R:V228	3.04	Yes	Yes	1	7	7
117	R:R:L267	R:R:V228	2.98	Yes	Yes	1	6	7
118	R:R:D232	R:R:K231	8.3	No	Yes	1	8	7
119	R:R:F235	R:R:K231	6.2	Yes	Yes	1	8	7
120	R:R:K231	R:R:V263	3.04	Yes	No	1	7	5
121	R:R:K231	R:R:L267	4.23	Yes	Yes	1	7	6
122	R:R:V234	R:R:V263	3.21	No	No	1	4	5
123	R:R:C260	R:R:F235	4.19	No	Yes	1	9	8
124	R:R:C330	R:R:F235	4.19	Yes	Yes	1	9	8
125	R:R:F235	R:R:T332	3.89	Yes	No	1	8	6
126	R:R:M256	R:R:S238	4.6	No	No	0	6	4
127	R:R:C330	R:R:Y239	5.38	Yes	Yes	0	9	4
128	R:R:K241	R:R:Y252	16.72	No	Yes	0	3	3
129	R:R:E255	R:R:K241	10.8	No	No	0	4	3
130	R:R:R242	R:R:Y252	4.12	No	Yes	0	2	3
131	R:R:P243	R:R:W249	10.81	No	Yes	3	3	3
132	R:R:P243	R:R:Y252	4.17	No	Yes	3	3	3
133	R:R:E246	R:R:N245	15.77	No	No	0	5	4
134	R:R:N245	R:R:S251	4.47	No	No	0	4	2
135	R:R:W249	R:R:Y252	5.79	Yes	Yes	3	3	3
136	R:R:C330	R:R:M256	4.86	Yes	No	0	9	6
137	R:R:C260	R:R:C330	7.28	No	Yes	1	9	9
138	R:R:N327	R:R:R261	12.05	No	No	7	7	8
139	R:R:R261	R:R:W331	26.99	No	Yes	7	8	9
140	R:R:L267	R:R:Q264	5.32	Yes	No	0	6	6
141	R:R:H268	R:R:Q264	11.13	Yes	No	0	7	6
142	R:R:F270	R:R:L266	3.65	Yes	No	0	5	5
143	R:R:H268	R:R:W318	9.52	Yes	Yes	1	7	8
144	R:R:H268	R:R:W340	7.41	Yes	Yes	1	7	6
145	R:R:H268	R:R:I343	3.98	Yes	No	1	7	7
146	R:R:F270	R:R:Y269	8.25	Yes	Yes	0	5	8
147	R:R:P311	R:R:Y269	8.34	No	Yes	0	9	8
148	R:R:V315	R:R:Y269	3.79	No	Yes	0	6	8
149	R:R:M347	R:R:V271	4.56	No	No	0	7	6
150	R:R:F314	R:R:G272	3.01	Yes	No	0	6	5
151	R:R:M347	R:R:Y275	10.78	No	No	0	7	7
152	R:R:F310	R:R:L276	6.09	No	No	0	3	7
153	R:R:L276	R:R:P311	3.28	No	No	0	7	9
154	R:R:V280	R:R:W277	3.68	No	Yes	0	8	9
155	R:R:L304	R:R:W277	3.42	No	Yes	0	5	9
156	R:R:G307	R:R:W277	8.44	No	Yes	0	9	9
157	R:R:W277	R:R:W308	18.74	Yes	Yes	6	9	9
158	R:R:L279	R:R:L283	4.15	No	No	0	8	6
159	R:R:C350	R:R:L279	4.76	No	No	0	7	8
160	R:R:L279	R:R:V353	2.98	No	No	0	8	6
161	R:R:L306	R:R:V280	2.98	No	No	0	7	8
162	R:R:E281	R:R:L393	9.28	Yes	No	0	9	9
163	R:R:L288	R:R:Y284	5.86	No	Yes	0	8	9
164	R:R:Y284	R:R:Y303	2.98	Yes	No	0	9	7
165	R:R:I361	R:R:L285	5.71	No	No	0	9	9
166	R:R:E290	R:R:H286	4.92	No	No	0	6	8
167	R:R:H286	R:R:I357	6.63	No	No	0	8	8
168	R:R:H286	R:R:K360	9.17	No	No	0	8	8
169	R:R:R297	R:R:T287	5.17	Yes	No	0	5	7
170	R:R:L288	R:R:V293	4.47	No	No	0	8	7
171	R:R:E290	R:R:L289	5.3	No	No	0	6	8
172	R:R:L289	R:R:L364	4.15	No	No	0	8	8
173	R:R:L294	R:R:R297	10.93	No	Yes	0	6	5
174	R:R:R297	R:R:Y303	4.12	Yes	No	0	5	7
175	R:R:R298	R:R:W300	16.99	No	No	0	5	6
176	R:R:L299	R:R:Y303	4.69	No	No	0	4	7
177	R:R:A309	R:R:L305	3.15	No	No	0	5	3
178	R:R:F310	R:R:L306	4.87	No	No	0	3	7
179	R:R:F310	R:R:F314	4.29	No	Yes	0	3	6
180	R:R:F314	R:R:P311	4.33	Yes	No	0	6	9
181	R:R:L313	R:R:V312	2.98	No	No	0	4	3
182	R:R:F314	R:R:V315	3.93	Yes	No	0	6	6
183	R:R:F314	R:R:P346	11.56	Yes	No	0	6	9
184	R:R:P317	R:R:V316	3.53	No	No	0	4	3
185	R:R:F320	R:R:V316	5.24	No	No	0	4	3
186	R:R:I339	R:R:W318	5.87	No	Yes	0	4	8
187	R:R:I343	R:R:W318	10.57	No	Yes	1	7	8
188	R:R:R322	R:R:W331	11	No	Yes	0	8	9
189	R:R:E326	R:R:L325	9.28	No	No	8	6	3
190	R:R:L325	R:R:N336	4.12	No	Yes	8	3	6
191	R:R:E326	R:R:N336	3.94	No	Yes	8	6	6
192	R:R:N327	R:R:W331	6.78	No	Yes	7	7	9
193	R:R:T328	R:R:T333	4.71	No	No	0	4	4
194	R:R:N334	R:R:W340	11.3	No	Yes	0	7	6
195	R:R:K338	R:R:N336	5.6	No	Yes	0	2	6
196	R:R:I339	R:R:N336	5.66	No	Yes	0	4	6
197	R:R:I343	R:R:W340	3.52	No	Yes	1	7	6
198	R:R:R344	R:R:W340	14.99	No	Yes	1	6	6
199	R:R:R344	R:R:W341	15.99	No	No	1	6	7
200	R:R:D406	R:R:W341	6.7	No	No	1	5	7
201	R:R:D406	R:R:R344	11.91	No	No	1	5	6
202	R:R:G345	R:R:P346	4.06	No	No	0	4	9
203	R:R:C350	R:R:L349	4.76	No	No	0	7	3
204	R:R:I399	R:R:V351	3.07	No	No	0	6	7
205	R:R:S402	R:R:V351	4.85	No	No	0	6	7
206	R:R:F356	R:R:T352	10.38	No	No	0	3	4
207	R:R:I357	R:R:V353	3.07	No	No	0	8	6
208	R:R:L394	R:R:N354	6.87	Yes	No	0	9	9
209	R:R:F355	R:R:L359	8.53	No	No	0	6	5
210	R:R:I357	R:R:I361	2.94	No	No	0	8	9
211	R:R:F358	R:R:L390	6.09	No	No	0	9	9
212	R:R:F358	R:R:V396	3.93	No	No	0	9	7
213	R:R:L362	R:R:T387	4.42	No	No	0	7	9
214	R:R:K368	R:R:L364	7.05	No	No	0	9	8
215	R:R:L365	R:R:S386	3	No	No	0	9	9
216	R:R:I366	R:R:K370	5.82	No	No	9	6	6
217	R:R:I366	R:R:Y379	3.63	No	Yes	9	6	7
218	R:R:I366	R:R:L383	5.71	No	No	0	6	9
219	R:R:L369	R:R:Y379	7.03	No	Yes	0	8	7
220	R:R:L369	R:R:R382	3.64	No	No	0	8	8
221	R:R:K370	R:R:Y379	5.97	No	Yes	9	6	7
222	R:R:M374	R:R:Y379	3.59	No	Yes	0	5	7
223	R:R:C375	R:R:D378	4.67	No	No	0	5	5
224	R:R:F376	R:R:Y379	5.16	No	Yes	0	7	7
225	R:R:F376	R:R:K380	12.41	No	No	0	7	7
226	R:R:K380	R:R:R377	4.95	No	No	0	7	6
227	R:R:K385	R:R:Y381	3.58	No	No	0	8	7
228	R:R:K385	R:R:R382	6.19	No	No	0	8	8
229	R:R:Q435	R:R:V389	11.46	No	No	0	8	8
230	R:R:I391	R:R:P392	3.39	No	No	0	8	9
231	R:R:H428	R:R:P392	3.05	Yes	No	0	9	9
232	R:R:L393	R:R:L394	4.15	No	Yes	0	9	9
233	R:R:L393	R:R:Y436	19.93	No	No	0	9	8
234	R:R:L394	R:R:V396	2.98	Yes	No	0	9	7
235	R:R:G395	R:R:H428	3.18	No	Yes	0	9	9
236	R:R:E398	R:R:H397	19.69	No	No	0	8	8
237	R:R:H397	R:R:L424	5.14	No	No	0	8	6
238	R:R:H397	R:R:H428	10.75	No	Yes	0	8	9
239	R:R:F401	R:R:L400	8.53	No	No	0	6	6
240	R:R:F401	R:R:I420	3.77	No	No	0	6	5
241	R:R:F401	R:R:Q421	9.37	No	No	0	6	8
242	R:R:I404	R:R:Q408	8.23	No	No	0	5	3
243	R:R:I404	R:R:R417	5.01	No	Yes	0	5	8
244	R:R:D407	R:R:T405	2.89	No	No	0	4	8
245	R:R:Q408	R:R:T405	5.67	No	No	0	3	8
246	R:R:D406	R:R:D407	5.32	No	No	0	5	4
247	R:R:F412	R:R:L415	3.65	No	Yes	0	1	4
248	R:R:K414	R:R:R417	4.95	No	Yes	4	5	8
249	R:R:K414	R:R:L418	5.64	No	No	4	5	5
250	R:R:F419	R:R:L415	12.18	No	Yes	0	6	4
251	R:R:F419	R:R:I416	5.02	No	No	0	6	5
252	R:R:L418	R:R:R417	3.64	No	Yes	4	5	8
253	R:R:Q421	R:R:R417	4.67	No	Yes	0	8	8
254	R:R:F427	R:R:F430	4.29	No	No	0	8	7
255	R:R:Q435	R:R:Y436	5.64	No	No	0	8	8
256	R:R:N440	R:R:V443	5.91	No	Yes	0	9	9
257	R:R:E446	R:R:K449	5.4	No	No	2	8	7
258	R:R:K449	R:R:Y450	3.58	No	No	2	7	5
259	R:R:K449	R:R:R453	6.19	No	No	2	7	7
260	R:R:R453	R:R:Y450	6.17	No	No	2	7	5
261	R:R:P301	R:R:R298	2.88	No	No	0	3	5
262	R:R:L197	R:R:M215	2.83	No	No	0	6	6
263	R:R:A196	R:R:F218	2.77	No	Yes	0	9	9
264	R:R:A196	R:R:F438	2.77	No	Yes	0	9	9
265	R:R:L206	R:R:N211	2.75	Yes	No	2	9	9
266	L:L:I27	L:L:Q28	2.74	No	No	0	0	0
267	L:L:S5	R:R:R417	2.64	No	Yes	0	0	8
268	R:R:R382	R:R:S386	2.64	No	No	0	8	9
269	R:R:F355	R:R:V396	2.62	No	No	0	6	7
270	R:R:R453	R:R:V452	2.62	No	No	0	7	4
271	R:R:A219	R:R:W308	2.59	No	Yes	0	4	9
272	R:R:A273	R:R:W308	2.59	No	Yes	0	7	9
273	R:R:R322	R:R:T328	2.59	No	No	0	8	4
274	R:R:A323	R:R:W331	2.59	No	Yes	0	4	9
275	R:R:S189	R:R:Y186	2.54	No	Yes	0	9	7
276	R:R:V312	R:R:Y269	2.52	No	Yes	0	3	8
277	R:R:V351	R:R:Y275	2.52	No	No	0	7	7
278	R:R:V265	R:R:W331	2.45	No	Yes	0	6	9
279	R:R:F438	R:R:L195	2.44	Yes	No	0	9	6
280	R:R:F438	R:R:L199	2.44	Yes	No	0	9	8
281	R:R:F358	R:R:L362	2.44	No	No	0	9	7
282	R:R:F430	R:R:L431	2.44	No	No	0	7	6
283	R:R:F438	R:R:L434	2.44	Yes	No	0	9	5
284	R:R:I342	R:R:W318	2.35	No	Yes	0	8	8
285	L:L:L17	R:R:Y172	2.34	No	Yes	0	0	1
286	L:L:D15	R:R:Y239	2.3	No	Yes	0	0	4
287	R:R:F355	R:R:F356	2.14	No	No	0	6	3
288	R:R:R448	R:R:W451	2	No	No	0	5	5
289	R:R:G185	R:R:V184	1.84	No	No	0	8	6
290	R:R:P295	R:R:V293	1.77	No	No	0	6	7
291	R:R:P291	R:R:T287	1.75	No	No	0	5	7
292	R:R:G437	R:R:L200	1.71	No	No	0	9	8
293	R:R:G282	R:R:L285	1.71	No	No	0	9	9
294	R:R:G282	R:R:L394	1.71	No	Yes	0	9	9
295	R:R:G335	R:R:N336	1.7	No	Yes	0	3	6
296	R:R:I342	R:R:P317	1.69	No	No	0	8	4
297	R:R:E410	R:R:G411	1.64	No	No	0	4	4
298	R:R:A321	R:R:I339	1.62	No	No	0	4	4
299	R:R:A321	R:R:I342	1.62	No	No	0	4	8
300	R:R:S187	R:R:T183	1.6	No	No	0	6	7
301	R:R:V230	R:R:V234	1.6	No	No	1	6	4
302	R:R:V230	R:R:V263	1.6	No	No	1	6	5
303	R:R:S257	R:R:T258	1.6	No	No	0	4	3
304	R:R:S259	R:R:T258	1.6	No	No	0	4	3
305	R:R:S386	R:R:T387	1.6	No	No	0	9	9
306	R:R:A439	R:R:L434	1.58	No	No	0	6	5
307	R:R:I191	R:R:S192	1.55	No	No	0	3	6
308	R:R:M181	R:R:T423	1.51	No	No	0	6	5
309	R:R:G411	R:R:R171	1.5	No	No	0	4	4
310	R:R:G329	R:R:R261	1.5	No	No	0	4	8
311	R:R:L203	R:R:V443	1.49	No	Yes	2	8	9
312	R:R:L206	R:R:V443	1.49	Yes	Yes	2	9	9
313	R:R:L447	R:R:V443	1.49	No	Yes	0	5	9
314	R:R:N237	R:R:V233	1.48	No	No	0	3	3
315	L:L:I23	L:L:I27	1.47	No	No	0	0	0
316	R:R:L174	R:R:T177	1.47	No	No	0	4	3
317	R:R:L199	R:R:T198	1.47	No	No	0	8	1
318	R:R:L388	R:R:T387	1.47	No	No	0	8	9
319	R:R:L424	R:R:T423	1.47	No	No	0	6	5
320	R:R:D170	R:R:V169	1.46	No	No	0	1	3
321	R:R:A371	R:R:H372	1.46	No	No	0	6	5
322	R:R:K241	R:R:M256	1.44	No	No	0	3	6
323	R:R:I222	R:R:L226	1.43	Yes	No	0	7	3
324	L:L:I23	L:L:N24	1.42	No	No	0	0	0
325	R:R:Q179	R:R:T183	1.42	Yes	No	0	5	7
326	R:R:G319	R:R:W318	1.41	No	Yes	0	5	8
327	R:R:G319	R:R:W331	1.41	No	Yes	0	5	9
328	R:R:D378	R:R:M374	1.39	No	No	0	5	5
329	R:R:D407	R:R:K337	1.38	No	No	0	4	6
330	L:L:L17	R:R:N168	1.37	No	Yes	0	0	3
331	R:R:D170	R:R:Q167	1.31	No	No	0	1	3
332	R:R:N237	R:R:Y236	1.16	No	No	0	3	4
333	R:R:N245	R:R:W249	1.13	No	Yes	0	4	3
334	R:R:R297	R:R:R302	1.07	Yes	No	0	5	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:H1	10.4225	4	1	0
2	L:L:F6	5.70167	6	1	0
3	L:L:S7	3.62	4	1	0
4	L:L:N11	7.865	4	1	0
5	L:L:F22	8.1725	4	3	0
6	L:L:W25	6.77667	6	3	0
7	R:R:N168	4.5825	4	0	3
8	R:R:Y172	3.884	5	0	1
9	R:R:Q179	5.06	5	1	5
10	R:R:Y182	6.424	5	1	7
11	R:R:Y186	5.82	8	1	7
12	R:R:L193	4.5975	4	0	9
13	R:R:L206	6.805	6	2	9
14	R:R:R210	5.5675	4	2	9
15	R:R:F218	3.5	4	0	9
16	R:R:F221	7.58714	7	1	8
17	R:R:I222	5.9525	4	5	7
18	R:R:R224	5.102	5	1	8
19	R:R:V228	5.2725	4	1	7
20	R:R:K231	4.9	6	1	7
21	R:R:F235	6.352	5	1	8
22	R:R:Y239	4.55	4	0	4
23	R:R:W249	10.74	5	3	3
24	R:R:Y252	7.7	4	3	3
25	R:R:L267	4.0975	4	1	6
26	R:R:H268	9.514	5	1	7
27	R:R:Y269	5.725	4	0	8
28	R:R:F270	6.7975	4	0	5
29	R:R:W277	10.472	5	6	9
30	R:R:E281	8.43	4	0	9
31	R:R:Y284	5.512	5	2	9
32	R:R:R297	5.3225	4	0	5
33	R:R:W308	6.882	5	6	9
34	R:R:F314	5.424	5	0	6
35	R:R:W318	5.944	5	1	8
36	R:R:C330	5.4275	4	1	9
37	R:R:W331	8.53667	6	7	9
38	R:R:N336	4.204	5	8	6
39	R:R:W340	9.136	5	1	6
40	R:R:Y379	5.076	5	9	7
41	R:R:L394	3.9275	4	0	9
42	R:R:L415	6.5575	4	0	4
43	R:R:R417	4.182	5	4	8
44	R:R:H428	6.5075	4	0	9
45	R:R:F438	2.5225	4	0	9
46	R:R:V443	2.595	4	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I404	R:R:R417	16.8575	5.01	No	Yes	0	5	8
2	R:R:I404	R:R:Q408	18.4972	8.23	No	No	0	5	3
3	R:R:Q408	R:R:T405	20.1285	5.67	No	No	0	3	8
4	R:R:D407	R:R:T405	21.7513	2.89	No	No	0	4	8
5	R:R:D406	R:R:D407	24.9715	5.32	No	No	0	5	4
6	R:R:D406	R:R:R344	26.5013	11.91	No	No	1	5	6
7	R:R:R344	R:R:W340	29.7384	14.99	No	Yes	1	6	6
8	L:L:H1	R:R:W340	34.48	8.46	Yes	Yes	1	0	6
9	R:R:L267	R:R:V228	11.9385	2.98	Yes	Yes	1	6	7
10	L:L:H1	R:R:L267	29.244	3.86	Yes	Yes	1	0	6
11	R:R:V228	R:R:Y186	45.3239	6.31	Yes	Yes	1	7	7
12	L:L:H1	R:R:V271	45.5859	13.84	Yes	No	0	0	6
13	R:R:R224	R:R:V271	49.4908	3.92	Yes	No	0	8	6
14	R:R:R224	R:R:Y186	96.6065	7.2	Yes	Yes	1	8	7
15	R:R:K231	R:R:L267	30.8034	4.23	Yes	Yes	1	7	6
16	R:R:D232	R:R:Q179	11.6426	6.53	No	Yes	1	8	5
17	R:R:D232	R:R:K231	19.41	8.3	No	Yes	1	8	7
18	L:L:F6	R:R:Y182	33.3855	12.38	Yes	Yes	1	0	7
19	R:R:Y182	R:R:Y186	63.0985	5.96	Yes	Yes	1	7	7
20	L:L:M10	R:R:Q179	21.7259	8.16	No	Yes	1	0	5
21	L:L:F6	R:R:L178	18.0112	4.87	Yes	No	1	0	5
22	R:R:L422	R:R:Y182	16.2744	3.52	No	Yes	1	7	7
23	R:R:L178	R:R:L422	14.5079	5.54	No	No	1	5	7
24	R:R:F235	R:R:K231	40.6542	6.2	Yes	Yes	1	8	7
25	L:L:M10	R:R:Y172	36.2803	4.79	No	Yes	0	0	1
26	R:R:C330	R:R:F235	33.9475	4.19	Yes	Yes	1	9	8
27	L:L:L17	R:R:Y172	19.7988	2.34	No	Yes	0	0	1
28	L:L:L17	R:R:N168	17.7112	1.37	No	Yes	0	0	3
29	R:R:K241	R:R:Y252	28.441	16.72	No	Yes	0	3	3
30	R:R:K241	R:R:M256	31.0781	1.44	No	No	0	3	6
31	R:R:C330	R:R:M256	33.7235	4.86	Yes	No	0	9	6
32	R:R:W249	R:R:Y252	21.6329	5.79	Yes	Yes	3	3	3
33	R:R:F419	R:R:L178	28.2973	10.96	No	No	0	6	5
34	R:R:F419	R:R:L415	20.1834	12.18	No	Yes	0	6	4
35	R:R:S426	R:R:Y186	15.7038	5.09	No	Yes	0	9	7
36	R:R:G185	R:R:S426	13.9923	3.71	No	No	0	8	9
37	R:R:F427	R:R:G185	10.5439	4.52	No	No	0	8	8
38	R:R:F221	R:R:R224	97.0883	3.21	Yes	Yes	1	8	8
39	R:R:F221	R:R:L193	19.596	7.31	Yes	Yes	0	8	9
40	R:R:F218	R:R:L193	14.0303	3.65	Yes	Yes	0	9	9
41	R:R:F221	R:R:V432	15.1164	3.93	Yes	No	0	8	9
42	R:R:F218	R:R:V432	13.7768	3.93	Yes	No	0	9	9
43	R:R:F221	R:R:L217	100	4.87	Yes	No	0	8	9
44	R:R:E281	R:R:L217	98.5124	5.3	Yes	No	0	9	9
45	R:R:E281	R:R:I213	25.0264	6.83	Yes	No	0	9	9
46	R:R:I213	R:R:Y284	22.4824	4.84	No	Yes	2	9	9
47	R:R:Y284	R:R:Y303	18.5648	2.98	Yes	No	0	9	7
48	R:R:L299	R:R:Y303	10.172	4.69	No	No	0	4	7
49	R:R:E281	R:R:H214	26.8985	12.31	Yes	No	0	9	9
50	R:R:H214	R:R:R210	25.9223	4.51	No	Yes	0	9	9
51	R:R:N211	R:R:R210	22.2499	8.44	No	Yes	2	9	9
52	R:R:L206	R:R:N211	20.8131	2.75	Yes	No	2	9	9
53	R:R:E281	R:R:L393	59.6332	9.28	Yes	No	0	9	9
54	R:R:N274	R:R:R224	32.2233	7.23	No	Yes	1	9	8
55	R:R:N274	R:R:S220	53.2435	5.96	No	No	0	9	9
56	R:R:S220	R:R:W308	52.0771	3.71	No	Yes	0	9	9
57	R:R:W277	R:R:W308	47.1791	18.74	Yes	Yes	6	9	9
58	R:R:F221	R:R:H428	13.1175	9.05	Yes	Yes	0	8	9
59	R:R:V280	R:R:W277	43.6758	3.68	No	Yes	0	8	9
60	R:R:L306	R:R:V280	42.4418	2.98	No	No	0	7	8
61	R:R:F310	R:R:L306	41.1993	4.87	No	No	0	3	7
62	R:R:F310	R:R:L276	12.416	6.09	No	No	0	3	7
63	R:R:L276	R:R:P311	11.0764	3.28	No	No	0	7	9
64	R:R:P311	R:R:Y269	19.4692	8.34	No	Yes	0	9	8
65	R:R:F270	R:R:Y269	16.7646	8.25	Yes	Yes	0	5	8
66	R:R:F310	R:R:F314	27.5705	4.29	No	Yes	0	3	6
67	R:R:F314	R:R:P311	11.1778	4.33	Yes	No	0	6	9
68	R:R:F314	R:R:V315	11.1651	3.93	Yes	No	0	6	6
69	L:L:H1	R:R:H268	33.7742	15.53	Yes	Yes	1	0	7
70	R:R:H268	R:R:W318	43.866	9.52	Yes	Yes	1	7	8
71	R:R:G319	R:R:W318	17.9352	1.41	No	Yes	0	5	8
72	R:R:G319	R:R:W331	15.7419	1.41	No	Yes	0	5	9
73	R:R:L267	R:R:Q264	14.7276	5.32	Yes	No	0	6	6
74	R:R:H268	R:R:Q264	13.6585	11.13	Yes	No	0	7	6
75	R:R:L393	R:R:L394	58.9359	4.15	No	Yes	0	9	9
76	R:R:G282	R:R:L394	22.3556	1.71	No	Yes	0	9	9
77	R:R:G282	R:R:L285	20.9187	1.71	No	No	0	9	9
78	R:R:I361	R:R:L285	19.4692	5.71	No	No	0	9	9
79	R:R:I357	R:R:I361	18.0958	2.94	No	No	0	8	9
80	R:R:I342	R:R:W318	11.275	2.35	No	Yes	0	8	8
81	R:R:I339	R:R:W318	15.7461	5.87	No	Yes	0	4	8
82	R:R:I339	R:R:N336	11.3849	5.66	No	Yes	0	4	6
83	R:R:L394	R:R:V396	37.4551	2.98	Yes	No	0	9	7
84	R:R:F358	R:R:V396	30.6512	3.93	No	No	0	9	7
85	R:R:F358	R:R:L362	27.8621	2.44	No	No	0	9	7
86	R:R:L362	R:R:T387	26.5309	4.42	No	No	0	7	9
87	R:R:S386	R:R:T387	23.7797	1.6	No	No	0	9	9
88	R:R:R382	R:R:S386	20.9145	2.64	No	No	0	8	9
89	R:R:L369	R:R:R382	16.549	3.64	No	No	0	8	8
90	R:R:L369	R:R:Y379	15.1545	7.03	No	Yes	0	8	7
91	R:R:A196	R:R:F218	19.6087	2.77	No	Yes	0	9	9
92	R:R:A196	R:R:F438	16.8322	2.77	No	Yes	0	9	9
93	L:L:F6	L:L:M10	16.3716	4.98	Yes	No	1	0	0
94	R:R:Q179	R:R:Y182	18.5944	4.51	Yes	Yes	1	5	7
95	R:R:K231	R:R:V228	33.4446	3.04	Yes	Yes	1	7	7
96	R:R:F221	R:R:N274	22.1739	15.71	Yes	No	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:H1	R:R:L267	3.86	1	Yes	Yes	0	6	0	1
L:L:H1	R:R:H268	15.53	1	Yes	Yes	0	7	0	1
L:L:H1	R:R:V271	13.84	1	Yes	No	0	6	0	1
L:L:H1	R:R:W340	8.46	1	Yes	Yes	0	6	0	1
L:L:A2	R:R:Q421	4.55	0	No	No	0	8	0	1
L:L:D3	R:R:Y186	6.9	1	No	Yes	0	7	0	1
L:L:D3	R:R:V228	8.76	1	No	Yes	0	7	0	1
L:L:F6	R:R:L175	3.65	1	Yes	No	0	5	0	1
L:L:F6	R:R:L178	4.87	1	Yes	No	0	5	0	1
L:L:F6	R:R:Q179	4.68	1	Yes	Yes	0	5	0	1
L:L:F6	R:R:Y182	12.38	1	Yes	Yes	0	7	0	1
L:L:F6	R:R:L422	3.65	1	Yes	No	0	7	0	1
L:L:S7	R:R:K231	4.59	1	Yes	Yes	0	7	0	1
L:L:S7	R:R:T332	3.2	1	Yes	No	0	6	0	1
L:L:D8	R:R:T333	2.89	0	No	No	0	4	0	1
L:L:D8	R:R:N334	4.04	0	No	No	0	7	0	1
L:L:E9	R:R:K414	6.75	0	No	No	0	5	0	1
L:L:M10	R:R:Y172	4.79	1	No	Yes	0	1	0	1
L:L:M10	R:R:Q179	8.16	1	No	Yes	0	5	0	1
L:L:N11	R:R:F235	13.29	1	Yes	Yes	0	8	0	1
L:L:N11	R:R:Y239	3.49	1	Yes	Yes	0	4	0	1
L:L:N11	R:R:T332	11.7	1	Yes	No	0	6	0	1
L:L:I13	R:R:R171	3.76	0	No	No	0	4	0	1
L:L:I13	R:R:Y172	3.63	0	No	Yes	0	1	0	1
L:L:L14	R:R:Y172	4.69	0	No	Yes	0	1	0	1
L:L:L14	R:R:Y239	7.03	0	No	Yes	0	4	0	1
L:L:N16	R:R:N168	8.17	0	No	Yes	0	3	0	1
L:L:A18	R:R:R242	4.15	0	No	No	0	2	0	1
L:L:R20	R:R:F165	3.21	0	No	No	0	1	0	1
L:L:D21	R:R:R242	19.06	0	No	No	0	2	0	1
L:L:F22	R:R:W249	20.04	3	Yes	Yes	0	3	0	1
L:L:W25	R:R:D244	5.58	3	Yes	No	0	1	0	1
L:L:W25	R:R:N247	3.39	3	Yes	No	0	4	0	1
L:L:W25	R:R:W249	15.93	3	Yes	Yes	0	3	0	1
R:R:F165	R:R:N168	4.83	0	No	Yes	1	3	1	1
R:R:N168	R:R:Q167	3.96	0	Yes	No	3	3	1	2
R:R:L415	R:R:R171	4.86	0	Yes	No	4	4	2	1
R:R:Y172	R:R:Y236	3.97	0	Yes	No	1	4	1	2
R:R:F419	R:R:L178	10.96	0	No	No	6	5	2	1
R:R:L178	R:R:L422	5.54	1	No	No	5	7	1	1
R:R:Q179	R:R:Y182	4.51	1	Yes	Yes	5	7	1	1
R:R:D232	R:R:Q179	6.53	1	No	Yes	8	5	2	1
R:R:Y182	R:R:Y186	5.96	1	Yes	Yes	7	7	1	1
R:R:D232	R:R:Y182	5.75	1	No	Yes	8	7	2	1
R:R:L422	R:R:Y182	3.52	1	No	Yes	7	7	1	1
R:R:R224	R:R:Y186	7.2	1	Yes	Yes	8	7	2	1
R:R:T225	R:R:Y186	8.74	0	No	Yes	8	7	2	1
R:R:V228	R:R:Y186	6.31	1	Yes	Yes	7	7	1	1
R:R:S425	R:R:Y186	3.82	1	No	Yes	6	7	2	1
R:R:S426	R:R:Y186	5.09	0	No	Yes	9	7	2	1
R:R:R224	R:R:V271	3.92	1	Yes	No	8	6	2	1
R:R:R224	R:R:S425	3.95	1	Yes	No	8	6	2	2
R:R:K231	R:R:V228	3.04	1	Yes	Yes	7	7	1	1
R:R:L267	R:R:V228	2.98	1	Yes	Yes	6	7	1	1
R:R:D232	R:R:K231	8.3	1	No	Yes	8	7	2	1
R:R:F235	R:R:K231	6.2	1	Yes	Yes	8	7	1	1
R:R:K231	R:R:V263	3.04	1	Yes	No	7	5	1	2
R:R:K231	R:R:L267	4.23	1	Yes	Yes	7	6	1	1
R:R:C260	R:R:F235	4.19	1	No	Yes	9	8	2	1
R:R:C330	R:R:F235	4.19	1	Yes	Yes	9	8	2	1
R:R:F235	R:R:T332	3.89	1	Yes	No	8	6	1	1
R:R:C330	R:R:Y239	5.38	1	Yes	Yes	9	4	2	1
R:R:R242	R:R:Y252	4.12	0	No	Yes	2	3	1	2
R:R:P243	R:R:W249	10.81	3	No	Yes	3	3	2	1
R:R:P243	R:R:Y252	4.17	3	No	Yes	3	3	2	2
R:R:W249	R:R:Y252	5.79	3	Yes	Yes	3	3	1	2
R:R:C260	R:R:C330	7.28	1	No	Yes	9	9	2	2
R:R:L267	R:R:Q264	5.32	1	Yes	No	6	6	1	2
R:R:H268	R:R:Q264	11.13	1	Yes	No	7	6	1	2
R:R:H268	R:R:W318	9.52	1	Yes	Yes	7	8	1	2
R:R:H268	R:R:W340	7.41	1	Yes	Yes	7	6	1	1
R:R:H268	R:R:I343	3.98	1	Yes	No	7	7	1	2
R:R:M347	R:R:V271	4.56	0	No	No	7	6	2	1
R:R:I343	R:R:W318	10.57	1	No	Yes	7	8	2	2
R:R:T328	R:R:T333	4.71	0	No	No	4	4	2	1
R:R:N334	R:R:W340	11.3	0	No	Yes	7	6	1	1
R:R:I343	R:R:W340	3.52	1	No	Yes	7	6	2	1
R:R:R344	R:R:W340	14.99	1	No	Yes	6	6	2	1
R:R:F401	R:R:Q421	9.37	0	No	No	6	8	2	1
R:R:I404	R:R:R417	5.01	0	No	Yes	5	8	2	1
R:R:K414	R:R:R417	4.95	4	No	Yes	5	8	1	1
R:R:K414	R:R:L418	5.64	4	No	No	5	5	1	2
R:R:F419	R:R:L415	12.18	0	No	Yes	6	4	2	2
R:R:L418	R:R:R417	3.64	4	No	Yes	5	8	2	1
R:R:Q421	R:R:R417	4.67	0	No	Yes	8	8	1	1
L:L:S5	R:R:R417	2.64	0	No	Yes	0	8	0	1
R:R:S189	R:R:Y186	2.54	0	No	Yes	9	7	2	1
L:L:L17	R:R:Y172	2.34	0	No	Yes	0	1	0	1
L:L:D15	R:R:Y239	2.3	0	No	Yes	0	4	0	1
R:R:G411	R:R:R171	1.5	0	No	No	4	4	2	1
R:R:Q179	R:R:T183	1.42	1	Yes	No	5	7	1	2
L:L:L17	R:R:N168	1.37	0	No	Yes	0	3	0	1
R:R:N245	R:R:W249	1.13	0	No	Yes	4	3	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7D68_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.89
Number of Linked Nodes	294
Number of Links	334
Number of Hubs	46
Number of Links mediated by Hubs	183
Number of Communities	9
Number of Nodes involved in Communities	71
Number of Links involved in Communities	95

Path Summary
Number Of Nodes in MetaPath	97
Number Of Links MetaPath	96
Number of Shortest Paths	64302
Length Of Smallest Path	3
Average Path Length	13.6035
Length of Longest Path	30
Minimum Path Strength	1.32
Average Path Strength	5.99859
Maximum Path Strength	18.995
Minimum Path Correlation	0.7
Average Path Correlation	0.950896
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	64.4662
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.5826
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• peptide hormone receptor binding • protein binding • binding • corticotropin-releasing hormone receptor binding • signaling receptor binding • G protein-coupled receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • mu-type opioid receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • adrenergic receptor binding • D1 dopamine receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • ionotropic glutamate receptor binding • glutamate receptor binding • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • molecular function regulator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • insulin-like growth factor receptor binding • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • regulation of protein localization • positive regulation of biological process • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of protein localization to cell cortex • macromolecule localization • positive regulation of protein localization • intracellular protein localization • protein localization to cell cortex • cell division • response to ketone • response to lipid • response to alcohol • cellular response to forskolin • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • intracellular anatomical structure • cytoplasm • midbody • cell cortex • intracellular organelle • centrosome • microtubule organizing center • cytoskeleton • organelle • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • membrane-bounded organelle • nucleus • intracellular membrane-bounded organelle • protein-containing complex binding • binding • protein binding • enzyme binding • GTPase binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • synapse • cell junction • G-protein beta-subunit binding • signaling receptor binding • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • G protein-coupled receptor binding • glucagon receptor binding • hormone activity • identical protein binding • monosaccharide metabolic process • positive regulation of biological process • gluconeogenesis • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • small molecule metabolic process • regulation of carbohydrate metabolic process • regulation of glucose metabolic process • positive regulation of cellular process • positive regulation of gluconeogenesis • regulation of biosynthetic process • carbohydrate metabolic process • small molecule biosynthetic process • carbohydrate biosynthetic process • hexose metabolic process • primary metabolic process • monosaccharide biosynthetic process • hexose biosynthetic process • positive regulation of glucose metabolic process • biosynthetic process • regulation of gluconeogenesis • metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • glucose metabolic process • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of programmed cell death • regulation of apoptotic process • negative regulation of biological process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of cellular process • apoptotic process • programmed cell death • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • response to activity • negative regulation of execution phase of apoptosis • regulation of execution phase of apoptosis • execution phase of apoptosis • behavior • feeding behavior • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • positive regulation of establishment of protein localization • carbohydrate homeostasis • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • positive regulation of peptide hormone secretion • intracellular glucose homeostasis • cellular response to carbohydrate stimulus • chemical homeostasis • response to glucose • glucose homeostasis • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • homeostatic process • positive regulation of secretion by cell • positive regulation of protein transport • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • positive regulation of peptide secretion • cellular response to glucose stimulus • positive regulation of protein secretion • response to hexose • cellular homeostasis • positive regulation of transport • regulation of cellular localization • regulation of insulin secretion involved in cellular response to glucose stimulus • regulation of calcium ion import • regulation of calcium ion transport • positive regulation of calcium ion transport • positive regulation of calcium ion import • regulation of monoatomic ion transport • calcium ion transport • metal ion transport • positive regulation of monoatomic ion transport • monoatomic ion transport • calcium ion import • monoatomic cation transport • regulation of metal ion transport • membrane-enclosed lumen • endomembrane system • intracellular organelle lumen • endoplasmic reticulum lumen • organelle lumen • endoplasmic reticulum • extracellular region • vesicle lumen • intracellular vesicle • cytoplasmic vesicle lumen • secretory granule lumen • cytoplasmic vesicle • secretory granule • secretory vesicle • vesicle • extracellular space • glucagon receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • amide binding • peptide hormone binding • hormone binding • positive regulation of cell population proliferation • regulation of cell population proliferation • cell surface receptor signaling pathway
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O95838
Sequence	>7D68_nogp_Chain_R S F K Q N V D R Y A L L S T L Q L M Y T V G Y S F S L I S L F L A L T L L L F L R K L H C T R N Y I H M N L F A S F I L R T L A V L V K D V V F Y N S Y S K R P D N E N G W M S Y L S E M S T S C R S V Q V L L H Y F V G A N Y L W L L V E G L Y L H T L L E P T V L P E R R L W P R Y L L L G W A F P V L F V V P W G F A R A H L E N T G C W T T N G N K K I W W I I R G P M M L C V T V N F F I F L K I L K L L I S K L K A H Q M C F R D Y K Y R L A K S T L V L I P L L G V H E I L F S F I T D D Q V E G F A K L I R L F I Q L T L S S F H G F L V A L Q Y G F A N G E V K A E L R K Y W V R F L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7D68	B1	Peptide	Glucagon	GLP-2	Homo sapiens	GLP-2	-	Gs/β1/γ2	3	2020-12-16	doi.org/10.1038/s41422-020-00442-0
	7D68 (No Gprot)	B1	Peptide	Glucagon	GLP-2	Homo sapiens	GLP-2	-		3	2020-12-16	doi.org/10.1038/s41422-020-00442-0

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