Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F165 R:R:N168 4.83 0 No Yes 1 3 1 1
L:L:R20 R:R:F165 3.21 0 No No 0 1 0 1
R:R:N168 R:R:Q167 3.96 0 Yes No 3 3 1 2
L:L:N16 R:R:N168 8.17 0 No Yes 0 3 0 1
R:R:L415 R:R:R171 4.86 0 Yes No 4 4 2 1
L:L:I13 R:R:R171 3.76 0 No No 0 4 0 1
R:R:Y172 R:R:Y236 3.97 0 Yes No 1 4 1 2
L:L:M10 R:R:Y172 4.79 1 No Yes 0 1 0 1
L:L:I13 R:R:Y172 3.63 0 No Yes 0 1 0 1
L:L:L14 R:R:Y172 4.69 0 No Yes 0 1 0 1
L:L:F6 R:R:L175 3.65 1 Yes No 0 5 0 1
R:R:F419 R:R:L178 10.96 0 No No 6 5 2 1
R:R:L178 R:R:L422 5.54 1 No No 5 7 1 1
L:L:F6 R:R:L178 4.87 1 Yes No 0 5 0 1
R:R:Q179 R:R:Y182 4.51 1 Yes Yes 5 7 1 1
R:R:D232 R:R:Q179 6.53 1 No Yes 8 5 2 1
L:L:F6 R:R:Q179 4.68 1 Yes Yes 0 5 0 1
L:L:M10 R:R:Q179 8.16 1 No Yes 0 5 0 1
R:R:Y182 R:R:Y186 5.96 1 Yes Yes 7 7 1 1
R:R:D232 R:R:Y182 5.75 1 No Yes 8 7 2 1
R:R:L422 R:R:Y182 3.52 1 No Yes 7 7 1 1
L:L:F6 R:R:Y182 12.38 1 Yes Yes 0 7 0 1
R:R:R224 R:R:Y186 7.2 1 Yes Yes 8 7 2 1
R:R:T225 R:R:Y186 8.74 0 No Yes 8 7 2 1
R:R:V228 R:R:Y186 6.31 1 Yes Yes 7 7 1 1
R:R:S425 R:R:Y186 3.82 1 No Yes 6 7 2 1
R:R:S426 R:R:Y186 5.09 0 No Yes 9 7 2 1
L:L:D3 R:R:Y186 6.9 1 No Yes 0 7 0 1
R:R:R224 R:R:V271 3.92 1 Yes No 8 6 2 1
R:R:R224 R:R:S425 3.95 1 Yes No 8 6 2 2
R:R:K231 R:R:V228 3.04 1 Yes Yes 7 7 1 1
R:R:L267 R:R:V228 2.98 1 Yes Yes 6 7 1 1
L:L:D3 R:R:V228 8.76 1 No Yes 0 7 0 1
R:R:D232 R:R:K231 8.3 1 No Yes 8 7 2 1
R:R:F235 R:R:K231 6.2 1 Yes Yes 8 7 1 1
R:R:K231 R:R:V263 3.04 1 Yes No 7 5 1 2
R:R:K231 R:R:L267 4.23 1 Yes Yes 7 6 1 1
L:L:S7 R:R:K231 4.59 1 Yes Yes 0 7 0 1
R:R:C260 R:R:F235 4.19 1 No Yes 9 8 2 1
R:R:C330 R:R:F235 4.19 1 Yes Yes 9 8 2 1
R:R:F235 R:R:T332 3.89 1 Yes No 8 6 1 1
L:L:N11 R:R:F235 13.29 1 Yes Yes 0 8 0 1
R:R:C330 R:R:Y239 5.38 1 Yes Yes 9 4 2 1
L:L:N11 R:R:Y239 3.49 1 Yes Yes 0 4 0 1
L:L:L14 R:R:Y239 7.03 0 No Yes 0 4 0 1
R:R:R242 R:R:Y252 4.12 0 No Yes 2 3 1 2
L:L:A18 R:R:R242 4.15 0 No No 0 2 0 1
L:L:D21 R:R:R242 19.06 0 No No 0 2 0 1
R:R:P243 R:R:W249 10.81 17 No Yes 3 3 2 1
R:R:P243 R:R:Y252 4.17 17 No Yes 3 3 2 2
L:L:W25 R:R:D244 5.58 17 Yes No 0 1 0 1
L:L:W25 R:R:N247 3.39 17 Yes No 0 4 0 1
R:R:W249 R:R:Y252 5.79 17 Yes Yes 3 3 1 2
L:L:F22 R:R:W249 20.04 17 Yes Yes 0 3 0 1
L:L:W25 R:R:W249 15.93 17 Yes Yes 0 3 0 1
R:R:C260 R:R:C330 7.28 1 No Yes 9 9 2 2
R:R:L267 R:R:Q264 5.32 1 Yes No 6 6 1 2
R:R:H268 R:R:Q264 11.13 1 Yes No 7 6 1 2
L:L:H1 R:R:L267 3.86 1 Yes Yes 0 6 0 1
R:R:H268 R:R:W318 9.52 1 Yes Yes 7 8 1 2
R:R:H268 R:R:W340 7.41 1 Yes Yes 7 6 1 1
R:R:H268 R:R:I343 3.98 1 Yes No 7 7 1 2
L:L:H1 R:R:H268 15.53 1 Yes Yes 0 7 0 1
R:R:M347 R:R:V271 4.56 0 No No 7 6 2 1
L:L:H1 R:R:V271 13.84 1 Yes No 0 6 0 1
R:R:I343 R:R:W318 10.57 1 No Yes 7 8 2 2
R:R:T328 R:R:T333 4.71 0 No No 4 4 2 1
L:L:S7 R:R:T332 3.2 1 Yes No 0 6 0 1
L:L:N11 R:R:T332 11.7 1 Yes No 0 6 0 1
R:R:N334 R:R:W340 11.3 0 No Yes 7 6 1 1
L:L:D8 R:R:N334 4.04 0 No No 0 7 0 1
R:R:I343 R:R:W340 3.52 1 No Yes 7 6 2 1
R:R:R344 R:R:W340 14.99 1 No Yes 6 6 2 1
L:L:H1 R:R:W340 8.46 1 Yes Yes 0 6 0 1
R:R:F401 R:R:Q421 9.37 0 No No 6 8 2 1
R:R:I404 R:R:R417 5.01 0 No Yes 5 8 2 1
R:R:K414 R:R:R417 4.95 34 No Yes 5 8 1 1
R:R:K414 R:R:L418 5.64 34 No No 5 5 1 2
L:L:E9 R:R:K414 6.75 0 No No 0 5 0 1
R:R:F419 R:R:L415 12.18 0 No Yes 6 4 2 2
R:R:L418 R:R:R417 3.64 34 No Yes 5 8 2 1
R:R:Q421 R:R:R417 4.67 0 No Yes 8 8 1 1
L:L:A2 R:R:Q421 4.55 0 No No 0 8 0 1
L:L:F6 R:R:L422 3.65 1 Yes No 0 7 0 1
L:L:D8 R:R:T333 2.89 0 No No 0 4 0 1
L:L:S5 R:R:R417 2.64 0 No Yes 0 8 0 1
R:R:S189 R:R:Y186 2.54 0 No Yes 9 7 2 1
L:L:L17 R:R:Y172 2.34 0 No Yes 0 1 0 1
L:L:D15 R:R:Y239 2.3 0 No Yes 0 4 0 1
R:R:G411 R:R:R171 1.5 0 No No 4 4 2 1
R:R:Q179 R:R:T183 1.42 1 Yes No 5 7 1 2
L:L:L17 R:R:N168 1.37 0 No Yes 0 3 0 1
R:R:N245 R:R:W249 1.13 0 No Yes 4 3 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7D68
Class B1
SubFamily Peptide
Type Glucagon
SubType GLP-2
Species Homo sapiens
Ligand GLP-2
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3
Date 2020-12-16
D.O.I. 10.1038/s41422-020-00442-0
Net Summary
Imin 2.98
Number of Linked Nodes 888
Number of Links 1068
Number of Hubs 176
Number of Links mediated by Hubs 648
Number of Communities 34
Number of Nodes involved in Communities 254
Number of Links involved in Communities 344
Path Summary
Number Of Nodes in MetaPath 96
Number Of Links MetaPath 95
Number of Shortest Paths 1735784
Length Of Smallest Path 3
Average Path Length 32.4297
Length of Longest Path 65
Minimum Path Strength 1.22
Average Path Strength 6.54701
Maximum Path Strength 23.86
Minimum Path Correlation 0.7
Average Path Correlation 0.986438
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.5641
Average % Of Corr. Nodes 47.0798
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 47.0179
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP04896
Sequence
>7D68_Chain_A
DQRNEEKAQ REANKKIEK QLQKDKQVY RATHRLLLL GAGESGKST 
IVKQMTGIF ETKFQVDKV NFHMFDVGA QRDERRKWI QCFNDVTAI 
IFVVASSQT NRLQEALNL FKSIWNNRW LRTISVILF LNKQDLLAE 
KVLKIEDYF PEFARYTTP EDATPEPGE DPRVTRAKY FIRDEFLRI 
STASGDGRH YCYPHFTCS VDTENIRRV FNDCRDIIQ RMHLRQYEL 
L


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62871
Sequence
>7D68_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>7D68_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtO95838
Sequence
>7D68_Chain_R
SFKQNVDRY ALLSTLQLM YTVGYSFSL ISLFLALTL LLFLRKLHC 
TRNYIHMNL FASFILRTL AVLVKDVVF YNSYSKRPD NENGWMSYL 
SEMSTSCRS VQVLLHYFV GANYLWLLV EGLYLHTLL EPTVLPERR 
LWPRYLLLG WAFPVLFVV PWGFARAHL ENTGCWTTN GNKKIWWII 
RGPMMLCVT VNFFIFLKI LKLLISKLK AHQMCFRDY KYRLAKSTL 
VLIPLLGVH EILFSFITD DQVEGFAKL IRLFIQLTL SSFHGFLVA 
LQYGFANGE VKAELRKYW VRFL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
glp2_on7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
gs_glucagon6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
7DTY-GIP-GIP-Gs/&β;1/&γ;2
7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7D68B1PeptideGlucagonGLP-2Homo sapiensGLP-2-Gs/&β;1/&γ;232020-12-1610.1038/s41422-020-00442-0




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