psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:R26	R:R:R55	2.13	Yes	No	0	3	2
2	R:R:C57	R:R:R26	4.18	Yes	Yes	1	8	3
3	R:R:R26	R:R:V104	5.23	Yes	No	1	3	3
4	R:R:Q108	R:R:R26	2.34	Yes	Yes	1	5	3
5	R:R:P353	R:R:V27	3.53	No	No	0	3	3
6	R:R:H30	R:R:V28	9.69	No	No	30	4	3
7	R:R:E94	R:R:V28	4.28	No	No	30	5	3
8	R:R:R96	R:R:V28	15.69	Yes	No	0	4	3
9	R:R:A29	R:R:W354	2.59	No	Yes	0	5	5
10	R:R:E94	R:R:H30	4.92	No	No	30	5	4
11	R:R:M31	R:R:P32	3.35	No	No	0	5	3
12	R:R:L73	R:R:M31	4.24	No	No	0	5	5
13	R:R:G92	R:R:M31	1.75	Yes	No	0	9	5
14	R:R:G33	R:R:P32	2.03	No	No	0	9	3
15	R:R:G33	R:R:T90	3.64	No	No	0	9	6
16	R:R:G33	R:R:G92	2.11	No	Yes	0	9	9
17	R:R:D34	R:R:L425	6.79	No	No	0	8	3
18	R:R:I35	R:R:L91	2.85	No	No	0	6	9
19	R:R:I35	R:R:L411	2.85	No	No	0	6	8
20	R:R:G92	R:R:I36	1.76	Yes	No	0	9	4
21	R:R:I36	R:R:K141	4.36	No	No	0	4	4
22	R:R:I143	R:R:I36	2.94	Yes	No	0	6	4
23	R:R:G38	R:R:I37	1.76	No	No	0	9	8
24	R:R:I37	R:R:M407	5.83	No	No	0	8	5
25	R:R:G38	R:R:I143	1.76	No	Yes	0	9	6
26	R:R:A39	R:R:F41	4.16	No	Yes	1	7	8
27	R:R:A39	R:R:M72	3.22	No	Yes	1	7	8
28	R:R:L40	R:R:Q108	2.66	No	Yes	0	6	5
29	R:R:F112	R:R:L40	2.44	Yes	No	0	6	6
30	R:R:F41	R:R:R68	5.34	Yes	Yes	1	8	4
31	R:R:F41	R:R:V69	5.24	Yes	No	1	8	5
32	R:R:F41	R:R:M72	2.49	Yes	Yes	1	8	8
33	R:R:F41	R:R:I95	5.02	Yes	No	1	8	7
34	R:R:F41	R:R:Y172	6.19	Yes	Yes	1	8	7
35	R:R:S42	R:R:W100	4.94	No	No	0	6	3
36	R:R:H44	R:R:V43	5.54	Yes	Yes	1	7	5
37	R:R:G65	R:R:V43	5.52	No	Yes	0	5	5
38	R:R:D97	R:R:V43	4.38	No	Yes	1	9	5
39	R:R:V43	R:R:W354	4.9	Yes	Yes	1	5	5
40	R:R:C57	R:R:H44	2.95	Yes	Yes	1	8	7
41	R:R:H44	R:R:V60	2.77	Yes	No	0	7	5
42	R:R:D97	R:R:H44	6.3	No	Yes	1	9	7
43	R:R:H44	R:R:W354	4.23	Yes	Yes	1	7	5
44	R:R:A59	R:R:H45	2.93	No	No	0	4	1
45	R:R:H45	R:R:R61	11.28	No	No	0	1	5
46	R:R:Q46	R:R:W100	2.19	No	No	0	3	3
47	R:R:C57	R:R:P47	3.77	Yes	No	1	8	4
48	R:R:C99	R:R:P47	1.88	Yes	No	1	7	4
49	R:R:H101	R:R:P47	4.58	No	No	0	4	4
50	R:R:K51	R:R:T48	3	No	No	0	3	1
51	R:R:D50	R:R:K51	8.3	No	No	0	2	3
52	R:R:E54	R:R:K51	10.8	No	No	0	1	3
53	R:R:H53	R:R:V52	6.92	No	No	0	1	7
54	R:R:H101	R:R:V52	2.77	No	No	0	4	7
55	R:R:E54	R:R:H53	4.92	No	No	0	1	1
56	R:R:A103	R:R:R55	5.53	No	No	0	2	2
57	R:R:E107	R:R:R55	12.79	No	No	0	5	2
58	R:R:C57	R:R:C99	7.28	Yes	Yes	1	8	7
59	R:R:E357	R:R:V60	5.7	No	No	0	5	5
60	R:R:R61	R:R:Y64	7.2	No	No	0	5	4
61	R:R:E62	R:R:Q63	3.82	No	No	1	3	2
62	R:R:E62	R:R:F358	11.66	No	Yes	1	3	6
63	R:R:E62	R:R:R362	4.65	No	Yes	1	3	3
64	R:R:Q63	R:R:Q67	3.84	No	Yes	1	2	7
65	R:R:D394	R:R:Q63	6.53	Yes	No	1	5	2
66	R:R:R68	R:R:Y64	10.29	Yes	No	0	4	4
67	R:R:G65	R:R:I66	1.76	No	No	0	5	6
68	R:R:E70	R:R:I66	2.73	Yes	No	0	7	6
69	R:R:F358	R:R:I66	11.3	Yes	No	0	6	6
70	R:R:F337	R:R:Q67	4.68	Yes	Yes	1	7	7
71	R:R:Q67	R:R:Y341	3.38	Yes	Yes	1	7	6
72	R:R:D394	R:R:Q67	3.92	Yes	Yes	1	5	7
73	R:R:M397	R:R:Q67	2.72	Yes	Yes	1	6	7
74	R:R:R68	R:R:Y172	7.2	Yes	Yes	1	4	7
75	R:R:D394	R:R:R68	5.96	Yes	Yes	1	5	4
76	R:R:K396	R:R:R68	3.71	Yes	Yes	0	4	4
77	R:R:R68	R:R:V400	5.23	Yes	No	1	4	7
78	R:R:I95	R:R:V69	4.61	No	No	1	7	5
79	R:R:E70	R:R:Y340	2.24	Yes	Yes	1	7	8
80	R:R:E70	R:R:Y341	3.37	Yes	Yes	1	7	6
81	R:R:E70	R:R:L344	5.3	Yes	No	1	7	4
82	R:R:E70	R:R:N352	6.57	Yes	Yes	1	7	7
83	R:R:A71	R:R:F337	2.77	No	Yes	1	6	7
84	R:R:A71	R:R:M397	3.22	No	Yes	1	6	6
85	R:R:I95	R:R:M72	4.37	No	Yes	1	7	8
86	R:R:I404	R:R:M72	2.92	No	Yes	0	8	8
87	R:R:L73	R:R:R351	4.86	No	No	0	5	4
88	R:R:H74	R:R:R78	3.39	No	No	1	7	8
89	R:R:H74	R:R:W336	4.23	No	No	1	7	5
90	R:R:H74	R:R:Y340	32.67	No	Yes	1	7	8
91	R:R:I401	R:R:T75	9.12	No	No	31	8	9
92	R:R:T75	R:R:Y405	2.5	No	No	31	9	7
93	R:R:C93	R:R:L76	3.17	No	No	0	7	7
94	R:R:E77	R:R:Y340	2.24	No	Yes	1	7	8
95	R:R:E77	R:R:R351	11.63	No	No	1	7	4
96	R:R:R78	R:R:W336	10	No	No	1	8	5
97	R:R:I79	R:R:L85	2.85	No	No	0	9	6
98	R:R:N80	R:R:T90	2.92	No	No	0	9	6
99	R:R:D82	R:R:P83	6.44	No	No	0	6	3
100	R:R:D82	R:R:T84	4.34	No	No	0	6	2
101	R:R:L85	R:R:Y409	8.21	No	No	0	6	6
102	R:R:H412	R:R:L85	3.86	No	No	0	6	6
103	R:R:L86	R:R:L91	4.15	No	No	0	9	9
104	R:R:H412	R:R:L86	6.43	No	No	0	6	9
105	R:R:G424	R:R:I89	1.76	No	No	0	2	5
106	R:R:C93	R:R:G92	1.96	No	Yes	0	7	9
107	R:R:E94	R:R:F112	3.5	No	Yes	0	5	6
108	R:R:Q108	R:R:R96	14.02	Yes	Yes	0	5	4
109	R:R:E111	R:R:R96	5.82	No	Yes	0	3	4
110	R:R:F112	R:R:R96	10.69	Yes	Yes	0	6	4
111	R:R:C99	R:R:D97	6.22	Yes	No	1	7	9
112	R:R:A105	R:R:S98	3.42	No	No	0	6	6
113	R:R:P149	R:R:S98	1.78	Yes	No	0	6	6
114	R:R:C99	R:R:V104	3.42	Yes	No	1	7	3
115	R:R:S151	R:R:W100	6.18	No	No	0	4	3
116	R:R:Q108	R:R:V104	2.87	Yes	No	1	5	3
117	R:R:L106	R:R:L161	2.77	No	No	0	5	5
118	R:R:L106	S:S:L164	2.77	No	No	10	5	5
119	R:R:L106	S:S:F165	7.31	No	Yes	10	5	7
120	R:R:E107	S:S:L117	6.63	No	No	0	5	4
121	R:R:S109	R:R:V158	3.23	No	Yes	0	6	5
122	R:R:L161	R:R:S109	3	No	No	0	5	6
123	R:R:I110	R:R:I113	2.94	Yes	No	10	5	6
124	R:R:I110	R:R:L161	4.28	Yes	No	0	5	5
125	R:R:I110	S:S:I113	2.94	Yes	Yes	10	5	6
126	R:R:I110	S:S:R114	2.51	Yes	Yes	0	5	7
127	R:R:I110	S:S:F165	2.51	Yes	Yes	10	5	7
128	R:R:F112	R:R:I143	5.02	Yes	Yes	0	6	6
129	R:R:F165	R:R:I113	3.77	Yes	No	10	7	6
130	R:R:I113	S:S:I110	2.94	No	Yes	10	6	5
131	R:R:D115	R:R:R114	2.38	No	No	0	5	7
132	R:R:R114	S:S:R114	14.93	No	Yes	0	7	7
133	R:R:D115	R:R:K140	6.91	No	No	0	5	3
134	R:R:P142	R:R:S116	1.78	No	No	0	4	4
135	R:R:I143	R:R:S116	3.1	Yes	No	0	6	4
136	R:R:L117	S:S:E107	6.63	No	No	0	4	5
137	R:R:G145	R:R:I167	1.76	No	No	0	7	6
138	R:R:G145	R:R:M407	3.49	No	No	0	7	5
139	R:R:L162	R:R:V146	2.98	Yes	No	0	7	7
140	R:R:I147	R:R:Y172	2.42	No	Yes	0	7	7
141	R:R:G148	R:R:P149	4.06	No	Yes	0	8	6
142	R:R:G148	R:R:Y172	2.9	No	Yes	0	8	7
143	R:R:G150	R:R:P149	2.03	No	Yes	0	5	6
144	R:R:P149	R:R:V154	3.53	Yes	No	0	6	4
145	R:R:A155	R:R:P149	1.87	No	Yes	0	8	6
146	R:R:P149	R:R:V158	1.77	Yes	Yes	0	6	5
147	R:R:G150	R:R:S173	1.86	No	No	0	5	5
148	R:R:S151	R:R:S153	3.26	No	No	0	4	5
149	R:R:S151	R:R:V154	6.46	No	No	0	4	4
150	R:R:A174	R:R:S152	3.42	No	No	0	7	9
151	R:R:S152	R:R:S176	4.89	No	No	0	9	7
152	R:R:I156	R:R:N160	4.25	No	No	6	5	5
153	R:R:I156	R:R:L179	4.28	No	Yes	6	5	8
154	R:R:F185	R:R:I156	6.28	Yes	No	6	6	5
155	R:R:L162	R:R:V158	2.98	Yes	Yes	6	7	5
156	R:R:Q169	R:R:V158	2.87	Yes	Yes	6	8	5
157	R:R:Q159	R:R:Q163	5.12	Yes	No	6	7	5
158	R:R:Q159	R:R:Q169	7.68	Yes	Yes	6	7	8
159	R:R:F185	R:R:Q159	3.51	Yes	Yes	6	6	7
160	R:R:Q159	R:R:Y187	3.38	Yes	Yes	6	7	7
161	R:R:F188	R:R:Q159	4.68	Yes	Yes	6	8	7
162	R:R:F185	R:R:N160	2.42	Yes	No	6	6	5
163	R:R:I167	R:R:L162	2.85	No	Yes	0	6	7
164	R:R:L162	R:R:Q169	2.66	Yes	Yes	6	7	8
165	R:R:Q163	R:R:Y187	2.25	No	Yes	6	5	7
166	R:R:F165	R:R:L164	2.44	Yes	No	10	7	5
167	R:R:L164	S:S:L106	2.77	No	No	10	5	5
168	R:R:F165	S:S:L106	7.31	Yes	No	10	7	5
169	R:R:F165	S:S:I110	2.51	Yes	Yes	10	7	5
170	R:R:N166	R:R:Y187	12.79	No	Yes	0	4	7
171	R:R:I167	R:R:P168	3.39	No	No	0	6	9
172	R:R:P168	R:R:Y187	2.78	No	Yes	0	9	7
173	R:R:F188	R:R:Q169	4.68	Yes	Yes	6	8	8
174	R:R:I170	R:R:M407	2.92	No	No	0	7	5
175	R:R:A171	R:R:A174	1.79	No	No	0	9	7
176	R:R:A171	R:R:F188	2.77	No	Yes	0	9	8
177	R:R:S173	R:R:Y172	3.82	No	Yes	0	5	7
178	R:R:V400	R:R:Y172	3.79	No	Yes	1	7	7
179	R:R:K396	R:R:S173	3.06	Yes	No	0	4	5
180	R:R:T175	R:R:V192	3.17	No	Yes	0	8	7
181	R:R:D195	R:R:T175	7.23	Yes	No	0	8	8
182	R:R:L179	R:R:S176	4.5	Yes	No	0	8	7
183	R:R:M177	R:R:S194	3.07	Yes	No	0	5	8
184	R:R:D195	R:R:M177	2.77	Yes	Yes	8	8	5
185	R:R:A196	R:R:M177	3.22	No	Yes	8	3	5
186	R:R:M177	R:R:S226	3.07	Yes	No	0	5	4
187	R:R:A230	R:R:M177	3.22	No	Yes	8	4	5
188	R:R:D178	R:R:N222	2.69	No	No	0	5	6
189	R:R:F185	R:R:L179	4.87	Yes	Yes	6	6	8
190	R:R:F188	R:R:L179	10.96	Yes	Yes	6	8	8
191	R:R:L179	R:R:R190	4.86	Yes	Yes	6	8	9
192	R:R:R190	R:R:S180	3.95	Yes	No	6	9	8
193	R:R:D461	R:R:S180	5.89	Yes	No	6	8	8
194	R:R:D181	R:R:L184	4.07	No	No	0	6	6
195	R:R:L184	R:R:T183	2.95	No	No	0	6	2
196	R:R:F185	R:R:L184	3.65	Yes	No	0	6	6
197	R:R:K186	R:R:Y187	9.55	No	Yes	0	7	7
198	R:R:K186	R:R:R435	3.71	No	No	0	7	4
199	R:R:L438	R:R:Y187	4.69	No	Yes	0	5	7
200	R:R:F188	R:R:R190	3.21	Yes	Yes	6	8	9
201	R:R:L441	R:R:M189	4.24	No	No	0	6	6
202	R:R:G460	R:R:M189	1.75	No	No	0	7	6
203	R:R:R190	R:R:V192	2.62	Yes	Yes	0	9	7
204	R:R:R190	R:R:S194	3.95	Yes	No	0	9	8
205	R:R:D461	R:R:R190	9.53	Yes	Yes	6	8	9
206	R:R:F399	R:R:V191	3.93	No	No	0	7	9
207	R:R:F456	R:R:V191	2.62	Yes	No	0	9	9
208	R:R:P193	R:R:V192	1.77	Yes	Yes	0	8	7
209	R:R:F399	R:R:V192	7.87	No	Yes	0	7	7
210	R:R:P193	R:R:Q197	3.16	Yes	No	8	8	4
211	R:R:G464	R:R:P193	4.06	No	Yes	0	5	8
212	R:R:P193	R:R:Y466	4.17	Yes	Yes	8	8	9
213	R:R:D195	R:R:Q198	3.92	Yes	Yes	8	8	9
214	R:R:D195	R:R:Y223	8.05	Yes	Yes	8	8	7
215	R:R:A196	R:R:A230	1.79	No	No	8	3	4
216	R:R:Q197	R:R:Y466	4.51	No	Yes	8	4	9
217	R:R:Q198	R:R:Y223	2.25	Yes	Yes	8	9	7
218	R:R:F277	R:R:Q198	4.68	Yes	Yes	8	7	9
219	R:R:D305	R:R:Q198	11.75	No	Yes	0	8	9
220	R:R:I327	R:R:Q198	2.74	No	Yes	0	6	9
221	R:R:Q198	R:R:Y466	5.64	Yes	Yes	8	9	9
222	R:R:A199	R:R:A230	1.79	No	No	0	5	4
223	R:R:M234	R:R:R200	2.48	No	No	0	5	4
224	R:R:R200	R:R:W487	10	No	Yes	0	4	6
225	R:R:A201	R:R:W487	2.59	No	Yes	0	8	6
226	R:R:F231	R:R:M202	6.22	Yes	No	0	5	6
227	R:R:F277	R:R:M202	2.49	Yes	No	0	7	6
228	R:R:G303	R:R:M202	1.75	No	No	0	6	6
229	R:R:F231	R:R:V203	2.62	Yes	No	0	5	7
230	R:R:D204	R:R:W487	6.7	No	Yes	0	5	6
231	R:R:I205	R:R:I468	4.42	No	No	0	8	8
232	R:R:V206	R:R:W211	3.68	No	Yes	0	7	9
233	R:R:E238	R:R:K207	2.7	No	No	0	3	4
234	R:R:R208	R:R:Y209	4.12	No	Yes	16	5	8
235	R:R:L492	R:R:R208	2.43	No	No	0	5	5
236	R:R:D496	R:R:R208	7.15	No	No	16	3	5
237	R:R:W211	R:R:Y209	9.65	Yes	Yes	0	9	8
238	R:R:M494	R:R:Y209	7.18	No	Yes	16	6	8
239	R:R:D496	R:R:Y209	9.2	No	Yes	16	3	8
240	R:R:V499	R:R:Y209	3.79	No	Yes	16	7	8
241	R:R:W500	R:R:Y209	11.58	Yes	Yes	16	7	8
242	R:R:V273	R:R:W211	9.81	No	Yes	0	8	9
243	R:R:L300	R:R:W211	3.42	No	Yes	0	8	9
244	R:R:A243	R:R:Y213	5.34	Yes	Yes	13	9	9
245	R:R:K270	R:R:Y213	2.39	No	Yes	13	5	9
246	R:R:A271	R:R:Y213	2.67	No	Yes	13	6	9
247	R:R:C511	R:R:Y213	4.03	No	Yes	13	9	9
248	R:R:C531	R:R:Y213	2.69	No	Yes	13	9	9
249	R:R:V214	R:R:V273	3.21	No	No	0	8	8
250	R:R:L264	R:R:S215	3	No	No	13	7	8
251	R:R:A216	R:R:S245	3.42	No	No	0	5	4
252	R:R:E225	R:R:H218	2.46	No	No	0	5	4
253	R:R:H218	R:R:M228	9.19	No	No	0	4	4
254	R:R:H218	R:R:K247	7.86	No	No	0	4	5
255	R:R:C278	R:R:T219	3.38	No	No	32	4	5
256	R:R:T219	R:R:T282	7.85	No	No	32	5	4
257	R:R:E220	R:R:K247	17.55	No	No	0	7	5
258	R:R:E220	R:R:Y249	10.1	No	No	0	7	4
259	R:R:N222	R:R:S226	4.47	No	No	0	6	4
260	R:R:G224	R:R:Y223	4.35	No	Yes	8	8	7
261	R:R:F277	R:R:Y223	8.25	Yes	Yes	8	7	7
262	R:R:E279	R:R:Y223	2.24	No	Yes	0	4	7
263	R:R:S304	R:R:Y223	3.82	Yes	Yes	8	8	7
264	R:R:F277	R:R:G224	3.01	Yes	No	8	7	8
265	R:R:G227	R:R:S226	1.86	No	No	0	6	4
266	R:R:F277	R:R:G227	6.02	Yes	No	0	7	6
267	R:R:F231	R:R:M228	3.73	Yes	No	0	5	4
268	R:R:D233	R:R:E229	3.9	No	No	0	4	5
269	R:R:F231	R:R:S235	2.64	Yes	No	0	5	6
270	R:R:A275	R:R:F231	2.77	No	Yes	0	6	5
271	R:R:I242	R:R:K232	4.36	No	No	0	6	4
272	R:R:K232	R:R:S245	6.12	No	No	0	4	4
273	R:R:D233	R:R:K237	2.77	No	No	0	4	4
274	R:R:I240	R:R:S235	3.1	No	No	0	6	6
275	R:R:C241	R:R:V528	3.42	No	No	0	9	6
276	R:R:C241	R:R:C530	3.64	No	No	0	9	9
277	R:R:A243	R:R:H267	4.39	Yes	No	0	9	3
278	R:R:A243	R:R:A271	1.79	Yes	No	13	9	6
279	R:R:H244	R:R:Y246	7.62	No	Yes	0	6	5
280	R:R:L260	R:R:Y246	4.69	Yes	Yes	13	5	5
281	R:R:K263	R:R:Y246	15.53	No	Yes	0	4	5
282	R:R:L264	R:R:Y246	5.86	No	Yes	13	7	5
283	R:R:F257	R:R:I248	3.77	No	No	0	4	6
284	R:R:I248	R:R:L260	2.85	No	Yes	0	6	5
285	R:R:N251	R:R:Y249	4.65	No	No	0	3	4
286	R:R:E279	R:R:S250	2.87	No	No	0	4	3
287	R:R:M281	R:R:S250	3.07	No	No	0	2	3
288	R:R:S250	R:R:T282	3.2	No	No	0	3	4
289	R:R:A252	R:R:G253	1.95	No	No	33	2	3
290	R:R:A252	R:R:S256	3.42	No	No	33	2	3
291	R:R:G253	R:R:S256	1.86	No	No	33	3	3
292	R:R:D258	R:R:E254	10.39	No	No	34	3	1
293	R:R:E254	R:R:R292	15.12	No	No	34	1	3
294	R:R:F257	R:R:G285	4.52	No	No	0	4	1
295	R:R:D258	R:R:R292	3.57	No	No	34	3	3
296	R:R:K259	R:R:K263	2.87	No	No	0	3	4
297	R:R:L260	R:R:L264	4.15	Yes	No	13	5	7
298	R:R:L260	R:R:L286	4.15	Yes	No	0	5	5
299	R:R:A289	R:R:L261	3.15	No	No	0	6	5
300	R:R:L261	R:R:M290	2.83	No	No	0	5	4
301	R:R:L261	R:R:L293	2.77	No	No	0	5	3
302	R:R:L268	R:R:T265	2.95	No	No	0	4	4
303	R:R:L268	R:R:P269	3.28	No	No	0	4	7
304	R:R:E298	R:R:L268	6.63	No	No	0	3	4
305	R:R:C511	R:R:K270	6.47	No	No	13	9	5
306	R:R:E298	R:R:R272	9.3	No	No	0	3	5
307	R:R:I507	R:R:R272	2.51	No	No	0	8	5
308	R:R:C276	R:R:V274	3.42	No	Yes	0	5	6
309	R:R:F299	R:R:V274	3.93	Yes	Yes	0	7	6
310	R:R:L301	R:R:V274	4.47	No	Yes	0	8	6
311	R:R:C276	R:R:C278	1.82	No	No	0	5	4
312	R:R:C276	R:R:G303	1.96	No	No	0	5	6
313	R:R:F277	R:R:S304	6.61	Yes	Yes	8	7	8
314	R:R:C278	R:R:T282	8.45	No	No	32	4	4
315	R:R:G280	R:R:R310	3	No	No	0	3	5
316	R:R:M281	R:R:R284	2.48	No	No	0	2	2
317	R:R:V283	R:R:W307	9.81	No	Yes	7	5	7
318	R:R:V283	R:R:V313	3.21	No	No	7	5	4
319	R:R:M288	R:R:R284	3.72	No	No	19	3	2
320	R:R:R284	R:R:Y317	7.2	No	Yes	19	2	3
321	R:R:G285	R:R:M288	1.75	No	No	0	1	3
322	R:R:L287	R:R:Y317	2.34	No	Yes	19	4	3
323	R:R:E320	R:R:L287	3.98	Yes	No	19	4	4
324	R:R:M288	R:R:Y317	11.97	No	Yes	19	3	3
325	R:R:F299	R:R:M290	4.98	Yes	No	0	7	4
326	R:R:L301	R:R:M290	2.83	No	No	0	8	4
327	R:R:R291	R:R:Y317	6.17	No	Yes	19	3	3
328	R:R:E320	R:R:R291	3.49	Yes	No	19	4	3
329	R:R:L293	R:R:R292	2.43	No	No	0	3	3
330	R:R:F299	R:R:L295	4.87	Yes	No	0	7	3
331	R:R:A296	R:R:G297	1.95	No	No	0	5	4
332	R:R:E298	R:R:F299	5.83	No	Yes	0	3	7
333	R:R:I507	R:R:L300	2.85	No	No	0	8	8
334	R:R:I325	R:R:L302	2.85	No	No	0	6	7
335	R:R:D305	R:R:S304	2.94	No	Yes	0	8	8
336	R:R:G306	R:R:S304	1.86	No	Yes	0	5	8
337	R:R:V313	R:R:W307	7.36	No	Yes	7	4	7
338	R:R:T314	R:R:W307	2.43	No	Yes	7	3	7
339	R:R:T326	R:R:W307	7.28	No	Yes	0	6	7
340	R:R:W307	R:R:Y481	5.79	Yes	Yes	7	7	4
341	R:R:A308	R:R:K328	3.21	No	Yes	0	5	6
342	R:R:D309	R:R:K328	2.77	No	Yes	7	5	6
343	R:R:D309	R:R:M469	4.16	No	Yes	7	5	5
344	R:R:D309	R:R:Y481	5.75	No	Yes	7	5	4
345	R:R:D312	R:R:R310	11.91	No	No	0	1	5
346	R:R:R310	R:R:V313	3.92	No	No	0	5	4
347	R:R:D315	R:R:Y311	2.3	No	No	0	1	2
348	R:R:D480	R:R:Y311	5.75	No	No	7	1	2
349	R:R:Y311	R:R:Y481	4.96	No	Yes	7	2	4
350	R:R:F471	R:R:T314	3.89	Yes	No	7	6	3
351	R:R:T314	R:R:Y481	4.99	No	Yes	7	3	4
352	R:R:G316	R:R:Y317	2.9	No	Yes	0	3	3
353	R:R:G316	R:R:Q318	3.29	No	No	0	3	4
354	R:R:E320	R:R:Y317	10.1	Yes	Yes	19	4	3
355	R:R:F471	R:R:Q318	3.51	Yes	No	7	6	4
356	R:R:F479	R:R:Q318	15.23	No	No	7	3	4
357	R:R:A321	R:R:F471	2.77	No	Yes	0	6	6
358	R:R:G323	R:R:V322	1.84	No	No	0	8	5
359	R:R:G323	R:R:G324	2.11	No	No	0	8	7
360	R:R:I325	R:R:N470	2.83	No	No	0	6	8
361	R:R:M469	R:R:T326	3.01	Yes	No	0	5	6
362	R:R:E467	R:R:K328	2.7	No	Yes	0	8	6
363	R:R:K328	R:R:M469	2.88	Yes	Yes	7	6	5
364	R:R:L329	R:R:Y466	3.52	No	Yes	0	5	9
365	R:R:E467	R:R:Q330	6.37	No	No	0	8	5
366	R:R:P332	R:R:S331	1.78	No	No	0	3	5
367	R:R:P332	R:R:S450	3.56	No	No	0	3	4
368	R:R:V334	R:R:W336	7.36	No	No	0	6	5
369	R:R:F337	R:R:Y341	10.32	Yes	Yes	1	7	6
370	R:R:F337	R:R:Q393	7.03	Yes	Yes	1	7	5
371	R:R:F337	R:R:M397	2.49	Yes	Yes	1	7	6
372	R:R:D338	R:R:L342	2.71	No	Yes	1	4	4
373	R:R:D338	R:R:H391	7.56	No	No	1	4	4
374	R:R:D338	R:R:Q393	11.75	No	Yes	1	4	5
375	R:R:L344	R:R:Y340	2.34	No	Yes	1	4	8
376	R:R:R351	R:R:Y340	6.17	No	Yes	1	4	8
377	R:R:L342	R:R:Y341	2.34	Yes	Yes	1	4	6
378	R:R:F358	R:R:Y341	2.06	Yes	Yes	1	6	6
379	R:R:K388	R:R:L342	8.46	No	Yes	0	3	4
380	R:R:H391	R:R:L342	7.71	No	Yes	1	4	4
381	R:R:F355	R:R:L344	3.65	Yes	No	1	4	4
382	R:R:R345	R:R:T348	2.59	No	No	0	4	3
383	R:R:R345	R:R:T386	3.88	No	No	0	4	4
384	R:R:E347	R:R:P346	4.72	No	No	0	4	6
385	R:R:P346	R:R:W359	25.67	No	Yes	0	6	7
386	R:R:N349	R:R:N352	4.09	No	Yes	1	4	7
387	R:R:F355	R:R:N349	18.12	Yes	No	1	4	4
388	R:R:N352	R:R:P353	3.26	Yes	No	1	7	3
389	R:R:N352	R:R:W354	5.65	Yes	Yes	1	7	5
390	R:R:F355	R:R:N352	2.42	Yes	Yes	1	4	7
391	R:R:P353	R:R:W354	6.76	No	Yes	1	3	5
392	R:R:F355	R:R:Q356	2.34	Yes	No	1	4	3
393	R:R:F355	R:R:W359	4.01	Yes	Yes	0	4	7
394	R:R:F370	R:R:Q356	22.25	No	No	1	2	3
395	R:R:Q356	R:R:Q372	12.8	No	No	1	3	2
396	R:R:F358	R:R:R362	2.14	Yes	Yes	1	6	3
397	R:R:F363	R:R:W359	14.03	No	Yes	0	7	7
398	R:R:L387	R:R:W359	5.69	No	Yes	0	6	7
399	R:R:L367	R:R:Q360	6.65	No	No	0	2	6
400	R:R:N374	R:R:Q360	5.28	Yes	No	29	2	6
401	R:R:Q360	R:R:Y377	3.38	No	Yes	29	6	1
402	R:R:F363	R:R:R362	4.28	No	Yes	0	7	3
403	R:R:L387	R:R:R362	4.86	No	Yes	0	6	3
404	R:R:F363	R:R:L385	10.96	No	No	0	7	7
405	R:R:Q364	R:R:Y377	2.25	No	Yes	0	3	1
406	R:R:C365	R:R:C381	7.28	No	No	0	9	9
407	R:R:R366	R:R:T380	11.64	No	No	0	3	1
408	R:R:C381	R:R:L367	4.76	No	No	0	9	2
409	R:R:E368	R:R:G369	3.27	No	No	0	1	1
410	R:R:E368	R:R:E373	2.54	No	No	0	1	1
411	R:R:F370	R:R:P371	23.12	No	No	0	2	1
412	R:R:F370	R:R:Q372	5.86	No	No	1	2	2
413	R:R:K376	R:R:N374	4.2	No	Yes	29	1	2
414	R:R:N374	R:R:Y377	2.33	Yes	Yes	29	2	1
415	R:R:K376	R:R:Y377	8.36	No	Yes	29	1	1
416	R:R:K379	R:R:N378	9.79	No	No	0	3	1
417	R:R:N382	R:R:S384	8.94	No	No	0	5	3
418	R:R:K388	R:R:T386	12.01	No	No	0	3	4
419	R:R:H390	R:R:T389	5.48	No	No	0	5	1
420	R:R:H391	R:R:Q393	2.47	No	Yes	1	4	5
421	R:R:D394	R:R:M397	4.16	Yes	Yes	1	5	6
422	R:R:F399	R:R:K396	3.72	No	Yes	0	7	4
423	R:R:I401	R:R:Y405	2.42	No	No	31	8	7
424	R:R:N402	R:R:V449	2.96	No	No	0	7	3
425	R:R:I454	R:R:N402	7.08	No	No	0	7	7
426	R:R:F446	R:R:Y405	3.09	Yes	No	0	8	7
427	R:R:F446	R:R:S406	3.96	Yes	No	0	8	8
428	R:R:F456	R:R:S406	2.64	Yes	No	0	9	8
429	R:R:F446	R:R:Y409	10.32	Yes	No	0	8	6
430	R:R:G410	R:R:S440	1.86	No	Yes	0	8	5
431	R:R:G410	R:R:T444	1.82	No	No	0	8	7
432	R:R:L411	R:R:L437	2.77	No	No	0	8	7
433	R:R:L418	R:R:M414	4.24	No	Yes	0	3	5
434	R:R:M414	R:R:M429	2.89	Yes	Yes	0	5	3
435	R:R:I432	R:R:M414	2.92	No	Yes	0	4	5
436	R:R:M414	R:R:S440	3.07	Yes	Yes	0	5	5
437	R:R:M429	R:R:Q415	2.72	Yes	No	0	3	4
438	R:R:C419	R:R:P420	1.88	No	No	0	3	3
439	R:R:C419	R:R:C426	7.28	No	No	0	3	6
440	R:R:C419	R:R:M429	3.24	No	Yes	0	3	3
441	R:R:G424	R:R:Y422	2.9	No	No	0	2	1
442	R:R:K430	R:R:L425	2.82	No	No	0	1	3
443	R:R:A428	R:R:C426	1.81	No	No	0	3	6
444	R:R:D433	R:R:K436	13.83	No	No	0	4	7
445	R:R:L438	R:R:R435	3.64	No	No	0	5	4
446	R:R:L437	R:R:S440	3	No	Yes	0	7	5
447	R:R:L437	R:R:L441	4.15	No	No	0	7	6
448	R:R:E439	R:R:M442	4.06	No	No	0	3	5
449	R:R:K443	R:R:M442	7.2	No	No	0	4	5
450	R:R:F456	R:R:T444	2.59	Yes	No	0	9	7
451	R:R:L455	R:R:N445	9.61	No	No	0	3	5
452	R:R:F446	R:R:I454	12.56	Yes	No	0	8	7
453	R:R:G448	R:R:I454	1.76	No	No	0	5	7
454	R:R:D452	R:R:S450	7.36	No	No	0	5	4
455	R:R:F456	R:R:S462	2.64	Yes	No	0	9	4
456	R:R:D457	R:R:E458	3.9	No	No	0	7	4
457	R:R:D457	R:R:D461	5.32	No	Yes	0	7	8
458	R:R:E458	R:R:N459	6.57	No	No	0	4	6
459	R:R:D461	R:R:N459	2.69	Yes	No	0	8	6
460	R:R:P463	R:R:S462	1.78	No	No	0	3	4
461	R:R:P463	R:R:R465	2.88	No	No	0	3	5
462	R:R:N489	R:R:P463	6.52	No	No	0	3	3
463	R:R:D488	R:R:R465	8.34	No	No	0	4	5
464	R:R:W487	R:R:Y466	2.89	Yes	Yes	0	6	9
465	R:R:E467	R:R:N483	5.26	No	No	0	8	4
466	R:R:G485	R:R:I468	1.76	No	No	16	9	8
467	R:R:I468	R:R:M494	2.92	No	No	16	8	6
468	R:R:M469	R:R:Y481	2.39	Yes	Yes	7	5	4
469	R:R:K472	R:R:N470	8.39	No	No	0	6	8
470	R:R:N470	R:R:V484	2.96	No	No	0	8	8
471	R:R:F471	R:R:F479	6.43	Yes	No	7	6	3
472	R:R:F471	R:R:Y481	15.47	Yes	Yes	7	6	4
473	R:R:I482	R:R:K472	4.36	No	No	0	4	6
474	R:R:E473	R:R:G475	3.27	No	No	0	3	3
475	R:R:E473	R:R:F479	5.83	No	No	0	3	3
476	R:R:G475	R:R:M474	1.75	No	No	0	3	3
477	R:R:M474	R:R:Y478	4.79	No	No	0	3	2
478	R:R:D480	R:R:Y481	2.3	No	Yes	7	1	4
479	R:R:E498	R:R:V484	2.85	No	No	0	3	8
480	R:R:V484	R:R:V499	4.81	No	No	0	8	7
481	R:R:G485	R:R:S486	1.86	No	No	0	9	2
482	R:R:G485	R:R:M494	1.75	No	No	16	9	6
483	R:R:G490	R:R:W487	4.22	No	Yes	0	4	6
484	R:R:L492	R:R:W487	4.56	No	Yes	0	5	6
485	R:R:D495	R:R:E498	2.6	No	No	0	5	3
486	R:R:V499	R:R:W500	12.26	No	Yes	16	7	7
487	R:R:I506	R:R:W500	7.05	No	Yes	0	4	7
488	R:R:I507	R:R:W500	3.52	No	Yes	0	8	7
489	R:R:K502	R:R:S504	6.12	No	No	0	3	4
490	R:R:R508	R:R:V510	5.23	No	No	0	1	5
491	R:R:E513	R:R:R508	3.49	No	No	0	5	1
492	R:R:C511	R:R:C531	7.28	No	No	13	9	9
493	R:R:S512	R:R:W532	12.36	No	Yes	0	8	8
494	R:R:E513	R:R:P514	7.86	No	No	0	5	6
495	R:R:C515	R:R:Q519	3.05	No	Yes	20	9	6
496	R:R:C515	R:R:C534	7.28	No	No	20	9	9
497	R:R:E516	R:R:Q519	7.65	No	Yes	0	3	6
498	R:R:C534	R:R:Q519	6.1	No	Yes	20	9	6
499	R:R:I520	R:R:T535	4.56	No	No	0	6	4
500	R:R:I520	R:R:V543	3.07	No	No	0	6	7
501	R:R:C549	R:R:I520	6.55	No	No	0	9	6
502	R:R:E546	R:R:K521	14.85	No	No	20	7	8
503	R:R:K521	R:R:Y547	7.17	No	No	20	8	3
504	R:R:T533	R:R:V522	3.17	No	No	0	5	5
505	R:R:T535	R:R:V522	7.93	No	No	0	4	5
506	R:R:E527	R:R:R524	6.98	No	No	0	4	4
507	R:R:G526	R:R:K525	3.49	No	No	0	8	6
508	R:R:E527	R:R:V528	8.56	No	No	0	4	6
509	R:R:C531	R:R:E527	3.04	No	No	0	9	4
510	R:R:C530	R:R:W532	2.61	No	Yes	0	9	8
511	R:R:C534	R:R:W532	2.61	No	Yes	0	9	8
512	R:R:P536	R:R:T535	1.75	No	No	0	3	4
513	R:R:C537	R:R:C549	7.28	No	No	35	9	9
514	R:R:E541	R:R:K538	8.1	Yes	No	0	7	6
515	R:R:E541	R:R:N540	5.26	Yes	No	0	7	8
516	R:R:K550	R:R:Y542	8.36	No	No	0	3	7
517	R:R:P558	R:R:Y542	2.78	Yes	No	26	8	7
518	R:R:C565	R:R:Y542	2.69	Yes	No	26	9	7
519	R:R:F544	R:R:T548	3.89	No	No	0	5	4
520	R:R:F544	R:R:K550	2.48	No	No	0	5	3
521	R:R:D545	R:R:Y547	6.9	No	No	0	7	3
522	R:R:D545	R:R:T548	5.78	No	No	0	7	4
523	R:R:E546	R:R:Y547	2.24	No	No	20	7	3
524	R:R:C552	R:R:S556	5.16	No	No	26	9	5
525	R:R:C552	R:R:P558	1.88	No	Yes	26	9	8
526	R:R:C552	R:R:C565	7.28	No	Yes	26	9	9
527	R:R:L554	R:R:Y723	9.38	No	Yes	0	4	4
528	R:R:G555	R:R:V729	1.84	No	No	0	5	7
529	R:R:C565	R:R:S556	5.16	Yes	No	26	9	5
530	R:R:P558	R:R:W557	8.11	Yes	Yes	0	8	7
531	R:R:I568	R:R:W557	2.35	No	Yes	0	8	7
532	R:R:I726	R:R:W557	3.52	No	Yes	0	4	7
533	R:R:C565	R:R:P558	5.65	Yes	Yes	26	9	8
534	R:R:D566	R:R:T559	5.78	No	No	0	3	7
535	R:R:D560	R:R:D561	6.65	No	No	0	1	4
536	R:R:D561	R:R:T563	7.23	No	No	0	4	5
537	R:R:G564	R:R:T563	1.82	No	No	0	2	5
538	R:R:I568	R:R:P569	5.08	No	No	0	8	4
539	R:R:H721	R:R:V570	2.77	No	No	0	2	4
540	R:R:E728	R:R:Q571	5.1	No	No	0	5	6
541	R:R:Q571	R:R:Y730	4.51	No	Yes	0	6	6
542	R:R:K638	R:R:Y572	7.17	No	No	0	5	6
543	R:R:L731	R:R:Y572	4.69	No	No	0	6	6
544	R:R:G576	R:R:R574	3	No	No	0	3	6
545	R:R:D577	R:R:R574	10.72	No	No	0	7	6
546	R:R:V584	R:R:W575	2.45	Yes	No	0	5	5
547	R:R:I636	R:R:W575	3.52	No	No	0	8	5
548	R:R:D577	R:R:E579	2.6	No	Yes	37	7	6
549	R:R:D577	R:R:P580	3.22	No	No	37	7	7
550	R:R:E579	R:R:P578	11	Yes	No	0	6	3
551	R:R:E579	R:R:P580	3.14	Yes	No	37	6	7
552	R:R:E579	R:R:I800	4.1	Yes	No	0	6	8
553	R:R:I636	R:R:P580	6.77	No	No	0	8	7
554	R:R:A583	R:R:C803	1.81	No	No	0	8	7
555	R:R:A583	R:R:F804	4.16	No	No	0	8	7
556	R:R:F633	R:R:V584	6.55	Yes	Yes	0	6	5
557	R:R:F586	R:R:S807	6.61	No	No	0	3	8
558	R:R:F586	R:R:T811	2.59	No	No	0	3	6
559	R:R:A587	R:R:F633	2.77	No	Yes	0	7	6
560	R:R:A593	R:R:G590	1.95	No	No	0	4	6
561	R:R:G590	R:R:Y629	5.79	No	Yes	0	6	8
562	R:R:L591	R:R:Y629	3.52	No	Yes	0	6	8
563	R:R:L591	R:R:L630	6.92	No	No	0	6	6
564	R:R:T594	R:R:Y629	3.75	No	Yes	17	7	8
565	R:R:L814	R:R:T594	2.95	Yes	No	17	8	7
566	R:R:F596	R:R:V600	3.93	No	No	0	2	5
567	R:R:F601	R:R:V597	3.93	No	No	17	8	6
568	R:R:F818	R:R:V597	2.62	Yes	No	17	8	6
569	R:R:L622	R:R:T598	2.95	No	No	0	9	4
570	R:R:I603	R:R:V599	3.07	No	No	0	3	3
571	R:R:V600	R:R:V822	4.81	No	Yes	0	5	7
572	R:R:F601	R:R:F818	8.57	No	Yes	17	8	8
573	R:R:I603	R:R:Y604	6.04	No	No	0	3	5
574	R:R:T607	R:R:Y604	4.99	Yes	No	38	9	5
575	R:R:I825	R:R:Y604	4.84	No	No	38	8	5
576	R:R:D606	R:R:R605	4.76	No	No	0	4	5
577	R:R:P608	R:R:T607	6.99	No	Yes	0	7	9
578	R:R:T607	R:R:V609	3.17	Yes	Yes	0	9	6
579	R:R:I825	R:R:T607	7.6	No	Yes	38	8	9
580	R:R:S612	R:R:V609	3.23	No	Yes	0	9	6
581	R:R:K821	R:R:V609	3.04	No	Yes	0	9	6
582	R:R:S612	R:R:S613	3.26	No	Yes	21	9	9
583	R:R:N767	R:R:S612	8.94	No	No	21	8	9
584	R:R:K665	R:R:S613	3.06	Yes	Yes	21	9	9
585	R:R:N767	R:R:S613	4.47	No	Yes	21	8	9
586	R:R:K821	R:R:S613	4.59	No	Yes	0	9	9
587	R:R:L617	R:R:S614	6.01	No	No	21	8	9
588	R:R:K665	R:R:S614	7.65	Yes	No	21	9	9
589	R:R:E616	R:R:R615	2.33	No	No	0	7	8
590	R:R:R615	R:R:Y619	9.26	No	No	0	8	5
591	R:R:A661	R:R:L617	3.15	No	No	0	7	8
592	R:R:K665	R:R:L617	7.05	Yes	No	21	9	8
593	R:R:C618	R:R:F818	4.19	No	Yes	0	9	8
594	R:R:A661	R:R:I620	3.25	No	No	0	7	6
595	R:R:I621	R:R:S658	9.29	No	No	0	8	6
596	R:R:F818	R:R:L622	3.65	Yes	No	0	8	9
597	R:R:A623	R:R:G624	1.95	No	No	0	4	8
598	R:R:G624	R:R:M657	3.49	No	Yes	0	8	5
599	R:R:I625	R:R:Y629	6.04	No	Yes	17	8	8
600	R:R:I625	R:R:L814	8.56	No	Yes	17	8	8
601	R:R:C626	R:R:L630	3.17	No	No	0	4	6
602	R:R:L627	R:R:M657	2.83	No	Yes	0	5	5
603	R:R:G628	R:R:S654	3.71	No	No	0	6	7
604	R:R:G628	R:R:V806	1.84	No	No	0	6	8
605	R:R:S807	R:R:Y629	2.54	No	Yes	0	8	8
606	R:R:A810	R:R:Y629	4	No	Yes	0	7	8
607	R:R:T811	R:R:Y629	4.99	No	Yes	0	6	8
608	R:R:L814	R:R:Y629	2.34	Yes	Yes	17	8	8
609	R:R:F633	R:R:L630	2.44	Yes	No	0	6	6
610	R:R:C631	R:R:G650	1.96	No	No	0	7	5
611	R:R:F633	R:R:T632	3.89	Yes	No	0	6	7
612	R:R:C803	R:R:T632	5.07	No	No	0	7	7
613	R:R:L635	R:R:Q647	7.99	No	No	0	7	8
614	R:R:I799	R:R:L635	4.28	No	No	0	7	7
615	R:R:A637	R:R:Y643	2.67	No	No	0	8	7
616	R:R:K638	R:R:P639	3.35	No	No	0	5	9
617	R:R:K638	R:R:K640	15.8	No	No	0	5	5
618	R:R:C733	R:R:P639	1.88	No	No	0	9	9
619	R:R:I642	R:R:Q641	2.74	Yes	No	0	4	3
620	R:R:I642	R:R:Y645	7.25	Yes	Yes	39	4	4
621	R:R:I642	R:R:L646	5.71	Yes	No	39	4	5
622	R:R:C644	R:R:Q647	7.63	No	No	0	9	8
623	R:R:C644	R:R:R648	2.79	No	No	0	9	8
624	R:R:C644	R:R:C733	7.28	No	No	0	9	9
625	R:R:L646	R:R:Y645	8.21	No	Yes	39	5	4
626	R:R:F712	R:R:Y645	11.35	No	Yes	0	6	4
627	R:R:P717	R:R:Y645	2.78	No	Yes	0	8	4
628	R:R:F712	R:R:R648	5.34	No	No	0	6	8
629	R:R:R648	R:R:T735	3.88	No	No	0	8	6
630	R:R:G650	R:R:I649	5.29	No	No	0	5	5
631	R:R:I649	R:R:L653	4.28	No	Yes	0	5	6
632	R:R:G652	R:R:I651	1.76	No	No	0	5	7
633	R:R:I651	R:R:M802	5.83	No	No	0	7	8
634	R:R:G652	R:R:P655	4.06	No	Yes	0	5	8
635	R:R:G652	R:R:P743	2.03	No	No	0	5	7
636	R:R:L653	R:R:M657	2.83	Yes	Yes	0	6	5
637	R:R:L653	R:R:Q704	3.99	Yes	Yes	40	6	9
638	R:R:L653	R:R:L705	2.77	Yes	No	40	6	4
639	R:R:P655	R:R:S654	3.56	Yes	No	14	8	7
640	R:R:S654	W:W:?1	5.64	No	Yes	14	7	0
641	R:R:N747	R:R:P655	6.52	No	Yes	0	7	8
642	R:R:P655	W:W:?1	12.34	Yes	Yes	14	8	0
643	R:R:A656	R:R:Q704	6.06	No	Yes	0	8	9
644	R:R:I701	R:R:M657	2.92	No	Yes	0	7	5
645	R:R:S658	R:R:Y659	3.82	No	Yes	0	6	7
646	R:R:L750	R:R:Y659	2.34	No	Yes	0	9	7
647	R:R:I751	R:R:Y659	6.04	No	Yes	14	8	7
648	R:R:Y659	W:W:?1	1.76	Yes	Yes	14	7	0
649	R:R:L700	R:R:S660	4.5	No	No	0	4	9
650	R:R:L750	R:R:S660	3	No	No	0	9	9
651	R:R:L662	R:R:M817	4.24	No	No	0	6	8
652	R:R:C754	R:R:V663	3.42	No	No	0	8	7
653	R:R:Q693	R:R:T664	2.83	No	No	0	8	6
654	R:R:T666	R:R:Y757	4.99	No	No	0	9	7
655	R:R:N667	R:R:Y757	15.12	No	No	0	5	7
656	R:R:I672	R:R:R668	2.51	No	No	0	9	8
657	R:R:Q693	R:R:R668	9.35	No	No	0	8	8
658	R:R:F687	R:R:R671	5.34	No	No	0	5	7
659	R:R:M688	R:R:R671	8.69	No	No	0	5	7
660	R:R:I672	R:R:M688	2.92	No	No	0	9	5
661	R:R:A690	R:R:Q693	3.03	No	No	0	6	8
662	R:R:F698	R:R:L694	13.4	No	No	0	3	5
663	R:R:F698	R:R:I701	2.51	No	No	0	3	7
664	R:R:I703	R:R:L700	2.85	No	No	0	4	4
665	R:R:I701	R:R:Q704	4.12	No	Yes	0	7	9
666	R:R:I703	R:R:Y746	8.46	No	No	0	4	8
667	R:R:L705	R:R:Q704	9.32	No	Yes	40	4	9
668	R:R:I708	R:R:Q704	4.12	No	Yes	0	6	9
669	R:R:Q704	R:R:Y746	4.51	Yes	No	0	9	8
670	R:R:G706	R:R:V709	1.84	No	No	0	4	3
671	R:R:F712	R:R:I708	3.77	No	No	0	6	6
672	R:R:L711	R:R:T742	10.32	No	Yes	41	7	4
673	R:R:L711	R:R:P743	3.28	No	No	41	7	7
674	R:R:E715	R:R:M714	2.71	No	No	0	5	3
675	R:R:E715	R:R:T736	14.11	No	No	0	5	8
676	R:R:P716	R:R:P717	1.95	No	No	0	8	8
677	R:R:D718	R:R:I719	2.8	No	No	0	3	6
678	R:R:D718	R:R:N734	4.04	No	No	0	3	5
679	R:R:I719	R:R:L731	2.85	No	No	0	6	6
680	R:R:H721	R:R:Y723	2.18	No	Yes	0	2	4
681	R:R:H721	R:R:L731	2.57	No	No	0	2	6
682	R:R:D722	R:R:P724	16.1	No	No	36	6	3
683	R:R:D722	R:R:Y730	8.05	No	Yes	36	6	6
684	R:R:D722	R:R:I732	5.6	No	No	0	6	6
685	R:R:V729	R:R:Y723	7.57	No	Yes	0	7	4
686	R:R:P724	R:R:Y730	4.17	No	Yes	36	3	6
687	R:R:R727	R:R:S725	3.95	No	No	0	4	5
688	R:R:E728	R:R:R727	5.82	No	No	0	5	4
689	R:R:N796	R:R:Y730	4.65	No	Yes	0	5	6
690	R:R:G739	R:R:T736	1.82	No	No	0	7	8
691	R:R:L738	R:R:T742	5.9	No	Yes	0	2	4
692	R:R:V740	R:R:Y792	6.31	No	Yes	0	8	8
693	R:R:P743	R:R:T742	3.5	No	Yes	41	7	4
694	R:R:L744	W:W:?1	8.32	No	Yes	0	8	0
695	R:R:N747	R:R:Y746	2.33	No	No	0	7	8
696	R:R:G748	R:R:I751	1.76	No	No	14	5	8
697	R:R:G748	W:W:?1	5.14	No	Yes	14	5	0
698	R:R:I751	W:W:?1	4.29	No	Yes	14	8	0
699	R:R:L752	R:R:T755	2.95	No	No	14	3	8
700	R:R:F756	R:R:L752	2.44	No	No	14	4	3
701	R:R:L752	W:W:?1	2.08	No	Yes	14	3	0
702	R:R:F756	R:R:T755	3.89	No	No	14	4	8
703	R:R:A758	R:R:A775	1.79	No	No	0	9	9
704	R:R:K760	R:R:T761	3	No	No	0	7	8
705	R:R:T761	R:R:V764	3.17	No	Yes	0	8	8
706	R:R:A775	R:R:R762	4.15	No	No	0	9	9
707	R:R:P765	R:R:V764	3.53	No	Yes	0	9	8
708	R:R:E770	R:R:N767	13.15	No	No	0	9	8
709	R:R:K772	R:R:N769	5.6	No	No	0	9	9
710	R:R:F776	R:R:K772	8.69	No	No	0	8	9
711	R:R:P820	R:R:Y773	11.13	No	No	0	9	5
712	R:R:C816	R:R:T777	5.07	No	No	0	5	9
713	R:R:I791	R:R:T801	6.08	No	No	0	7	8
714	R:R:F793	R:R:Y792	10.32	No	Yes	0	6	8
715	R:R:K798	R:R:Y792	10.75	No	Yes	0	6	8
716	R:R:M802	R:R:Y792	3.59	No	Yes	0	8	8
717	R:R:G794	R:R:S795	1.86	No	No	0	8	8
718	R:R:S795	R:R:Y797	2.54	No	No	0	8	5
719	R:R:I800	R:R:Y797	3.63	No	No	0	8	5
720	R:R:F804	R:R:I800	8.79	No	No	0	7	8
721	R:R:S805	W:W:?1	5.64	No	Yes	0	8	0
722	R:R:V806	W:W:?1	5.6	No	Yes	0	8	0
723	R:R:S809	W:W:?1	13.54	No	Yes	0	9	0
724	R:R:A810	W:W:?1	2.37	No	Yes	0	7	0
725	R:R:F818	R:R:L814	3.65	Yes	Yes	17	8	8
726	R:R:G815	R:R:V819	3.68	No	No	0	2	4
727	R:R:F818	R:R:M817	8.71	Yes	No	0	8	8
728	R:R:P820	R:R:V819	3.53	No	No	0	9	4
729	R:R:V819	R:R:Y823	2.52	No	No	0	4	8
730	S:S:R26	S:S:R55	2.13	Yes	No	0	3	2
731	S:S:C57	S:S:R26	4.18	Yes	Yes	2	8	3
732	S:S:R26	S:S:V104	5.23	Yes	No	2	3	3
733	S:S:Q108	S:S:R26	2.34	Yes	Yes	2	5	3
734	S:S:P353	S:S:V27	3.53	No	No	0	3	3
735	S:S:H30	S:S:V28	6.92	No	No	22	4	3
736	S:S:E94	S:S:V28	4.28	No	No	22	5	3
737	S:S:R96	S:S:V28	14.38	Yes	No	0	4	3
738	S:S:A29	S:S:W354	2.59	No	Yes	0	5	5
739	S:S:E94	S:S:H30	4.92	No	No	22	5	4
740	S:S:M31	S:S:P32	3.35	No	No	0	5	3
741	S:S:L73	S:S:M31	4.24	No	No	0	5	5
742	S:S:G92	S:S:M31	1.75	Yes	No	0	9	5
743	S:S:G33	S:S:P32	2.03	No	No	0	9	3
744	S:S:G33	S:S:T90	3.64	No	No	0	9	6
745	S:S:G33	S:S:G92	2.11	No	Yes	0	9	9
746	S:S:D34	S:S:L425	6.79	No	No	0	8	3
747	S:S:I35	S:S:L91	2.85	No	No	0	6	9
748	S:S:I35	S:S:L411	4.28	No	No	0	6	8
749	S:S:G92	S:S:I36	1.76	Yes	No	0	9	4
750	S:S:I36	S:S:K141	4.36	No	No	0	4	4
751	S:S:I143	S:S:I36	2.94	Yes	No	0	6	4
752	S:S:G38	S:S:I37	1.76	No	No	0	9	8
753	S:S:I37	S:S:M407	5.83	No	No	0	8	5
754	S:S:F112	S:S:G38	3.01	Yes	No	22	6	9
755	S:S:G38	S:S:I143	1.76	No	Yes	22	9	6
756	S:S:A39	S:S:F41	4.16	No	Yes	3	7	8
757	S:S:A39	S:S:M72	3.22	No	Yes	3	7	8
758	S:S:L40	S:S:Q108	2.66	No	Yes	0	6	5
759	S:S:F112	S:S:L40	2.44	Yes	No	0	6	6
760	S:S:L40	S:S:V146	2.98	No	No	0	6	7
761	S:S:F41	S:S:R68	5.34	Yes	Yes	3	8	4
762	S:S:F41	S:S:V69	5.24	Yes	No	3	8	5
763	S:S:F41	S:S:M72	2.49	Yes	Yes	3	8	8
764	S:S:F41	S:S:I95	5.02	Yes	No	3	8	7
765	S:S:F41	S:S:Y172	6.19	Yes	Yes	3	8	7
766	S:S:S42	S:S:W100	4.94	No	No	0	6	3
767	S:S:H44	S:S:V43	5.54	Yes	Yes	2	7	5
768	S:S:G65	S:S:V43	5.52	No	Yes	0	5	5
769	S:S:D97	S:S:V43	4.38	No	Yes	2	9	5
770	S:S:V43	S:S:W354	4.9	Yes	Yes	2	5	5
771	S:S:C57	S:S:H44	4.42	Yes	Yes	2	8	7
772	S:S:H44	S:S:V60	4.15	Yes	No	0	7	5
773	S:S:D97	S:S:H44	6.3	No	Yes	2	9	7
774	S:S:H44	S:S:W354	4.23	Yes	Yes	2	7	5
775	S:S:A59	S:S:H45	2.93	No	No	0	4	1
776	S:S:H45	S:S:R61	11.28	No	No	0	1	5
777	S:S:Q46	S:S:W100	2.19	No	No	0	3	3
778	S:S:C57	S:S:P47	3.77	Yes	No	2	8	4
779	S:S:C99	S:S:P47	1.88	No	No	2	7	4
780	S:S:H101	S:S:P47	4.58	No	No	0	4	4
781	S:S:D50	S:S:K51	9.68	No	No	0	2	3
782	S:S:H53	S:S:V52	6.92	No	No	0	1	7
783	S:S:A103	S:S:R55	5.53	No	No	0	2	2
784	S:S:E107	S:S:R55	12.79	No	No	0	5	2
785	S:S:C57	S:S:C99	7.28	Yes	No	2	8	7
786	S:S:E357	S:S:V60	5.7	No	No	0	5	5
787	S:S:R61	S:S:Y64	7.2	No	No	0	5	4
788	S:S:E62	S:S:Q63	2.55	No	Yes	0	3	2
789	S:S:E62	S:S:F358	11.66	No	Yes	0	3	6
790	S:S:E62	S:S:H361	2.46	No	No	0	3	3
791	S:S:Q63	S:S:Q67	6.4	Yes	Yes	3	2	7
792	S:S:D394	S:S:Q63	2.61	Yes	Yes	3	5	2
793	S:S:R68	S:S:Y64	10.29	Yes	No	0	4	4
794	S:S:G65	S:S:I66	1.76	No	No	0	5	6
795	S:S:E70	S:S:I66	2.73	Yes	No	0	7	6
796	S:S:F358	S:S:I66	11.3	Yes	No	0	6	6
797	S:S:F337	S:S:Q67	4.68	Yes	Yes	3	7	7
798	S:S:Q67	S:S:Y341	3.38	Yes	Yes	3	7	6
799	S:S:D394	S:S:Q67	3.92	Yes	Yes	3	5	7
800	S:S:M397	S:S:Q67	2.72	Yes	Yes	3	6	7
801	S:S:R68	S:S:Y172	7.2	Yes	Yes	3	4	7
802	S:S:D394	S:S:R68	5.96	Yes	Yes	3	5	4
803	S:S:K396	S:S:R68	3.71	Yes	Yes	0	4	4
804	S:S:R68	S:S:V400	5.23	Yes	No	3	4	7
805	S:S:I95	S:S:V69	4.61	No	No	3	7	5
806	S:S:E70	S:S:Y341	3.37	Yes	Yes	0	7	6
807	S:S:E70	S:S:L344	5.3	Yes	No	0	7	4
808	S:S:E70	S:S:N352	6.57	Yes	Yes	0	7	7
809	S:S:A71	S:S:F337	2.77	No	Yes	3	6	7
810	S:S:A71	S:S:M397	3.22	No	Yes	3	6	6
811	S:S:L76	S:S:M72	2.83	No	Yes	0	7	8
812	S:S:I95	S:S:M72	4.37	No	Yes	3	7	8
813	S:S:I404	S:S:M72	2.92	No	Yes	0	8	8
814	S:S:L73	S:S:R351	4.86	No	No	0	5	4
815	S:S:H74	S:S:R78	2.26	No	No	15	7	8
816	S:S:H74	S:S:W336	3.17	No	Yes	15	7	5
817	S:S:H74	S:S:Y340	30.49	No	No	15	7	8
818	S:S:T75	S:S:W336	2.43	No	Yes	15	9	5
819	S:S:I401	S:S:T75	7.6	No	No	15	8	9
820	S:S:T75	S:S:Y405	2.5	No	No	15	9	7
821	S:S:C93	S:S:L76	3.17	No	No	0	7	7
822	S:S:E77	S:S:Y340	2.24	No	No	15	7	8
823	S:S:E77	S:S:R351	11.63	No	No	15	7	4
824	S:S:R78	S:S:W336	10	No	Yes	15	8	5
825	S:S:I79	S:S:L85	2.85	No	No	0	9	6
826	S:S:N80	S:S:T90	2.92	No	No	0	9	6
827	S:S:D82	S:S:P83	6.44	No	No	0	6	3
828	S:S:D82	S:S:T84	5.78	No	No	0	6	2
829	S:S:L85	S:S:Y409	8.21	No	No	0	6	6
830	S:S:H412	S:S:L85	3.86	No	No	0	6	6
831	S:S:L86	S:S:L91	4.15	No	No	0	9	9
832	S:S:H412	S:S:L86	6.43	No	No	0	6	9
833	S:S:I89	S:S:Q415	2.74	No	No	0	5	4
834	S:S:G424	S:S:I89	1.76	No	No	0	2	5
835	S:S:C93	S:S:G92	1.96	No	Yes	0	7	9
836	S:S:E94	S:S:F112	3.5	No	Yes	22	5	6
837	S:S:Q108	S:S:R96	15.19	Yes	Yes	0	5	4
838	S:S:E111	S:S:R96	5.82	No	Yes	0	3	4
839	S:S:F112	S:S:R96	11.76	Yes	Yes	0	6	4
840	S:S:C99	S:S:D97	6.22	No	No	2	7	9
841	S:S:A105	S:S:S98	3.42	No	No	0	6	6
842	S:S:P149	S:S:S98	1.78	Yes	No	0	6	6
843	S:S:S151	S:S:W100	6.18	No	No	0	4	3
844	S:S:Q108	S:S:V104	2.87	Yes	No	2	5	3
845	S:S:L106	S:S:L161	2.77	No	No	10	5	5
846	S:S:S109	S:S:V158	6.46	No	Yes	0	6	5
847	S:S:I110	S:S:I113	2.94	Yes	Yes	10	5	6
848	S:S:I110	S:S:R114	3.76	Yes	Yes	0	5	7
849	S:S:I110	S:S:L161	4.28	Yes	No	10	5	5
850	S:S:E111	S:S:R114	4.65	No	Yes	0	3	7
851	S:S:F112	S:S:I143	5.02	Yes	Yes	22	6	6
852	S:S:I113	S:S:L161	2.85	Yes	No	10	6	5
853	S:S:F165	S:S:I113	3.77	Yes	Yes	10	7	6
854	S:S:D115	S:S:R114	2.38	No	Yes	0	5	7
855	S:S:P142	S:S:S116	1.78	No	No	0	4	4
856	S:S:I143	S:S:S116	3.1	Yes	No	0	6	4
857	S:S:F165	S:S:L117	2.44	Yes	No	0	7	4
858	S:S:G145	S:S:I167	1.76	No	No	0	7	6
859	S:S:G145	S:S:M407	3.49	No	No	0	7	5
860	S:S:L162	S:S:V146	4.47	Yes	No	0	7	7
861	S:S:I147	S:S:Y172	2.42	No	Yes	0	7	7
862	S:S:I147	S:S:I404	2.94	No	No	0	7	8
863	S:S:G148	S:S:P149	4.06	No	Yes	0	8	6
864	S:S:G148	S:S:Y172	2.9	No	Yes	0	8	7
865	S:S:G150	S:S:P149	2.03	No	Yes	0	5	6
866	S:S:P149	S:S:V154	3.53	Yes	No	0	6	4
867	S:S:A155	S:S:P149	3.74	No	Yes	0	8	6
868	S:S:P149	S:S:V158	1.77	Yes	Yes	0	6	5
869	S:S:G150	S:S:S173	1.86	No	No	0	5	5
870	S:S:S151	S:S:S153	3.26	No	No	0	4	5
871	S:S:S151	S:S:V154	6.46	No	No	0	4	4
872	S:S:A174	S:S:S152	3.42	No	No	0	7	9
873	S:S:S152	S:S:S176	4.89	No	No	0	9	7
874	S:S:I156	S:S:N160	2.83	No	No	5	5	5
875	S:S:I156	S:S:L179	4.28	No	Yes	5	5	8
876	S:S:F185	S:S:I156	6.28	Yes	No	5	6	5
877	S:S:L162	S:S:V158	2.98	Yes	Yes	5	7	5
878	S:S:Q169	S:S:V158	2.87	Yes	Yes	5	8	5
879	S:S:Q159	S:S:Q163	5.12	Yes	No	5	7	5
880	S:S:Q159	S:S:Q169	7.68	Yes	Yes	5	7	8
881	S:S:F185	S:S:Q159	3.51	Yes	Yes	5	6	7
882	S:S:Q159	S:S:Y187	3.38	Yes	Yes	5	7	7
883	S:S:F188	S:S:Q159	4.68	Yes	Yes	5	8	7
884	S:S:F185	S:S:N160	2.42	Yes	No	5	6	5
885	S:S:I167	S:S:L162	2.85	No	Yes	0	6	7
886	S:S:L162	S:S:Q169	2.66	Yes	Yes	5	7	8
887	S:S:Q163	S:S:Y187	2.25	No	Yes	5	5	7
888	S:S:F165	S:S:L164	2.44	Yes	No	10	7	5
889	S:S:N166	S:S:Y187	12.79	No	Yes	0	4	7
890	S:S:I167	S:S:P168	3.39	No	No	0	6	9
891	S:S:P168	S:S:Y187	2.78	No	Yes	0	9	7
892	S:S:F188	S:S:Q169	4.68	Yes	Yes	5	8	8
893	S:S:I170	S:S:M407	2.92	No	No	0	7	5
894	S:S:A171	S:S:A174	1.79	No	No	0	9	7
895	S:S:A171	S:S:F188	2.77	No	Yes	0	9	8
896	S:S:S173	S:S:Y172	3.82	No	Yes	0	5	7
897	S:S:V400	S:S:Y172	3.79	No	Yes	3	7	7
898	S:S:K396	S:S:S173	3.06	Yes	No	0	4	5
899	S:S:T175	S:S:V192	3.17	No	Yes	0	8	7
900	S:S:D195	S:S:T175	7.23	Yes	No	0	8	8
901	S:S:L179	S:S:S176	4.5	Yes	No	0	8	7
902	S:S:N222	S:S:S176	2.98	No	No	0	6	7
903	S:S:M177	S:S:S194	3.07	Yes	No	0	5	8
904	S:S:D195	S:S:M177	2.77	Yes	Yes	9	8	5
905	S:S:A196	S:S:M177	3.22	No	Yes	9	3	5
906	S:S:M177	S:S:S226	3.07	Yes	No	0	5	4
907	S:S:A230	S:S:M177	3.22	No	Yes	9	4	5
908	S:S:D178	S:S:N222	5.39	No	No	0	5	6
909	S:S:F185	S:S:L179	4.87	Yes	Yes	5	6	8
910	S:S:F188	S:S:L179	10.96	Yes	Yes	5	8	8
911	S:S:L179	S:S:R190	4.86	Yes	Yes	5	8	9
912	S:S:R190	S:S:S180	3.95	Yes	No	5	9	8
913	S:S:D461	S:S:S180	5.89	Yes	No	5	8	8
914	S:S:D181	S:S:L184	4.07	No	No	0	6	6
915	S:S:L184	S:S:T183	2.95	No	No	0	6	2
916	S:S:F185	S:S:L184	3.65	Yes	No	0	6	6
917	S:S:K186	S:S:Y187	9.55	No	Yes	0	7	7
918	S:S:K186	S:S:R435	3.71	No	No	0	7	4
919	S:S:L438	S:S:Y187	4.69	No	Yes	0	5	7
920	S:S:F188	S:S:R190	3.21	Yes	Yes	5	8	9
921	S:S:L441	S:S:M189	4.24	No	No	0	6	6
922	S:S:G460	S:S:M189	1.75	No	No	0	7	6
923	S:S:R190	S:S:V192	2.62	Yes	Yes	0	9	7
924	S:S:R190	S:S:S194	3.95	Yes	No	0	9	8
925	S:S:D461	S:S:R190	9.53	Yes	Yes	5	8	9
926	S:S:F399	S:S:V191	3.93	No	No	0	7	9
927	S:S:F456	S:S:V191	2.62	Yes	No	0	9	9
928	S:S:P193	S:S:V192	3.53	Yes	Yes	0	8	7
929	S:S:F399	S:S:V192	9.18	No	Yes	0	7	7
930	S:S:P193	S:S:Q197	3.16	Yes	No	9	8	4
931	S:S:G464	S:S:P193	4.06	No	Yes	0	5	8
932	S:S:P193	S:S:Y466	4.17	Yes	Yes	9	8	9
933	S:S:D195	S:S:Q198	3.92	Yes	Yes	9	8	9
934	S:S:D195	S:S:Y223	8.05	Yes	Yes	9	8	7
935	S:S:A196	S:S:A230	1.79	No	No	9	3	4
936	S:S:Q197	S:S:Y466	4.51	No	Yes	9	4	9
937	S:S:Q198	S:S:Y223	2.25	Yes	Yes	9	9	7
938	S:S:F277	S:S:Q198	5.86	Yes	Yes	9	7	9
939	S:S:D305	S:S:Q198	11.75	No	Yes	0	8	9
940	S:S:I327	S:S:Q198	2.74	No	Yes	0	6	9
941	S:S:Q198	S:S:Y466	5.64	Yes	Yes	9	9	9
942	S:S:A199	S:S:A230	1.79	No	No	0	5	4
943	S:S:R200	S:S:W487	10	No	Yes	0	4	6
944	S:S:A201	S:S:W487	2.59	No	Yes	0	8	6
945	S:S:F231	S:S:M202	6.22	Yes	No	0	5	6
946	S:S:G303	S:S:M202	1.75	No	No	0	6	6
947	S:S:F231	S:S:V203	2.62	Yes	No	0	5	7
948	S:S:D204	S:S:W487	6.7	No	Yes	0	5	6
949	S:S:I205	S:S:I468	4.42	No	No	0	8	8
950	S:S:V206	S:S:W211	2.45	No	Yes	0	7	9
951	S:S:I240	S:S:V206	3.07	No	No	0	6	7
952	S:S:E238	S:S:K207	2.7	No	No	0	3	4
953	S:S:R208	S:S:Y209	4.12	No	Yes	11	5	8
954	S:S:L492	S:S:R208	2.43	No	No	0	5	5
955	S:S:D496	S:S:R208	7.15	No	No	11	3	5
956	S:S:W211	S:S:Y209	7.72	Yes	Yes	11	9	8
957	S:S:M494	S:S:Y209	7.18	No	Yes	11	6	8
958	S:S:D496	S:S:Y209	9.2	No	Yes	11	3	8
959	S:S:V499	S:S:Y209	3.79	No	Yes	11	7	8
960	S:S:W500	S:S:Y209	9.65	Yes	Yes	11	7	8
961	S:S:V273	S:S:W211	9.81	Yes	Yes	11	8	9
962	S:S:L300	S:S:W211	3.42	Yes	Yes	11	8	9
963	S:S:A243	S:S:Y213	5.34	No	Yes	27	9	9
964	S:S:K270	S:S:Y213	2.39	No	Yes	0	5	9
965	S:S:A271	S:S:Y213	2.67	No	Yes	27	6	9
966	S:S:C511	S:S:Y213	5.38	No	Yes	27	9	9
967	S:S:C531	S:S:Y213	2.69	No	Yes	27	9	9
968	S:S:V214	S:S:V273	3.21	No	Yes	0	8	8
969	S:S:L264	S:S:S215	3	No	No	0	7	8
970	S:S:A216	S:S:S245	3.42	No	No	0	5	4
971	S:S:E225	S:S:H218	2.46	No	No	0	5	4
972	S:S:H218	S:S:M228	9.19	No	No	0	4	4
973	S:S:H218	S:S:K247	6.55	No	No	0	4	5
974	S:S:C278	S:S:T219	3.38	No	No	43	4	5
975	S:S:T219	S:S:T282	7.85	No	No	43	5	4
976	S:S:E220	S:S:K247	14.85	No	No	0	7	5
977	S:S:E220	S:S:Y249	7.86	No	No	0	7	4
978	S:S:N222	S:S:S226	4.47	No	No	0	6	4
979	S:S:G224	S:S:Y223	4.35	No	Yes	9	8	7
980	S:S:F277	S:S:Y223	13.41	Yes	Yes	9	7	7
981	S:S:E279	S:S:Y223	2.24	No	Yes	0	4	7
982	S:S:S304	S:S:Y223	3.82	Yes	Yes	9	8	7
983	S:S:F277	S:S:G224	3.01	Yes	No	9	7	8
984	S:S:G227	S:S:S226	1.86	No	No	0	6	4
985	S:S:F277	S:S:G227	6.02	Yes	No	0	7	6
986	S:S:F231	S:S:M228	3.73	Yes	No	0	5	4
987	S:S:D233	S:S:E229	3.9	No	No	0	4	5
988	S:S:F231	S:S:S235	2.64	Yes	No	0	5	6
989	S:S:A275	S:S:F231	2.77	No	Yes	0	6	5
990	S:S:I242	S:S:K232	4.36	No	No	0	6	4
991	S:S:K232	S:S:S245	6.12	No	No	0	4	4
992	S:S:D233	S:S:K237	2.77	No	No	0	4	4
993	S:S:I240	S:S:S235	3.1	No	No	0	6	6
994	S:S:C241	S:S:V528	3.42	No	No	0	9	6
995	S:S:C241	S:S:C530	5.46	No	No	0	9	9
996	S:S:A243	S:S:H267	2.93	No	No	0	9	3
997	S:S:A243	S:S:A271	1.79	No	No	27	9	6
998	S:S:H244	S:S:Y246	9.8	No	Yes	0	6	5
999	S:S:L260	S:S:Y246	4.69	Yes	Yes	42	5	5
1000	S:S:K263	S:S:Y246	10.75	No	Yes	0	4	5
1001	S:S:L264	S:S:Y246	5.86	No	Yes	42	7	5
1002	S:S:H267	S:S:Y246	2.18	No	Yes	0	3	5
1003	S:S:F257	S:S:I248	3.77	No	No	0	4	6
1004	S:S:I248	S:S:L260	2.85	No	Yes	0	6	5
1005	S:S:N251	S:S:Y249	3.49	No	No	0	3	4
1006	S:S:A252	S:S:Y249	2.67	No	No	0	2	4
1007	S:S:E279	S:S:S250	2.87	No	No	0	4	3
1008	S:S:M281	S:S:S250	3.07	No	No	0	2	3
1009	S:S:S250	S:S:T282	3.2	No	No	0	3	4
1010	S:S:A252	S:S:G253	1.95	No	No	44	2	3
1011	S:S:A252	S:S:S256	3.42	No	No	44	2	3
1012	S:S:G253	S:S:S256	1.86	No	No	44	3	3
1013	S:S:D258	S:S:E254	11.69	No	No	45	3	1
1014	S:S:E254	S:S:R292	15.12	No	No	45	1	3
1015	S:S:F257	S:S:G285	4.52	No	No	0	4	1
1016	S:S:D258	S:S:R292	3.57	No	No	45	3	3
1017	S:S:K259	S:S:K263	2.87	No	No	0	3	4
1018	S:S:L260	S:S:L264	2.77	Yes	No	42	5	7
1019	S:S:L260	S:S:L286	2.77	Yes	No	0	5	5
1020	S:S:A289	S:S:L261	3.15	No	No	0	6	5
1021	S:S:L261	S:S:M290	4.24	No	No	0	5	4
1022	S:S:L261	S:S:L293	2.77	No	No	0	5	3
1023	S:S:L268	S:S:T265	2.95	No	No	0	4	4
1024	S:S:L268	S:S:P269	3.28	No	No	0	4	7
1025	S:S:E298	S:S:L268	6.63	Yes	No	0	3	4
1026	S:S:E298	S:S:R272	9.3	Yes	No	0	3	5
1027	S:S:I507	S:S:R272	2.51	No	No	0	8	5
1028	S:S:L300	S:S:V273	2.98	Yes	Yes	11	8	8
1029	S:S:C276	S:S:V274	3.42	No	Yes	0	5	6
1030	S:S:F299	S:S:V274	2.62	No	Yes	0	7	6
1031	S:S:L301	S:S:V274	4.47	No	Yes	0	8	6
1032	S:S:C276	S:S:C278	1.82	No	No	0	5	4
1033	S:S:C276	S:S:G303	1.96	No	No	0	5	6
1034	S:S:F277	S:S:S304	6.61	Yes	Yes	9	7	8
1035	S:S:C278	S:S:T282	8.45	No	No	43	4	4
1036	S:S:G280	S:S:R310	3	No	No	0	3	5
1037	S:S:M281	S:S:R284	2.48	No	No	0	2	2
1038	S:S:V283	S:S:W307	9.81	No	Yes	4	5	7
1039	S:S:V283	S:S:V313	3.21	No	No	4	5	4
1040	S:S:M288	S:S:R284	2.48	No	No	4	3	2
1041	S:S:R284	S:S:Y317	7.2	No	Yes	4	2	3
1042	S:S:G285	S:S:M288	1.75	No	No	0	1	3
1043	S:S:L287	S:S:T314	2.95	Yes	Yes	4	4	3
1044	S:S:L287	S:S:Y317	2.34	Yes	Yes	4	4	3
1045	S:S:E320	S:S:L287	3.98	Yes	Yes	4	4	4
1046	S:S:A321	S:S:L287	3.15	No	Yes	0	6	4
1047	S:S:M288	S:S:Y317	10.78	No	Yes	4	3	3
1048	S:S:R291	S:S:Y317	10.29	No	Yes	4	3	3
1049	S:S:E320	S:S:R291	6.98	Yes	No	4	4	3
1050	S:S:L293	S:S:R292	2.43	No	No	0	3	3
1051	S:S:E298	S:S:L295	2.65	Yes	No	46	3	3
1052	S:S:F299	S:S:L295	6.09	No	No	46	7	3
1053	S:S:A296	S:S:G297	1.95	No	No	0	5	4
1054	S:S:E298	S:S:F299	7	Yes	No	46	3	7
1055	S:S:I507	S:S:L300	2.85	No	Yes	0	8	8
1056	S:S:I325	S:S:L302	2.85	No	No	0	6	7
1057	S:S:D305	S:S:S304	2.94	No	Yes	0	8	8
1058	S:S:G306	S:S:S304	1.86	No	Yes	0	5	8
1059	S:S:V313	S:S:W307	7.36	No	Yes	4	4	7
1060	S:S:T314	S:S:W307	3.64	Yes	Yes	4	3	7
1061	S:S:T326	S:S:W307	8.49	No	Yes	0	6	7
1062	S:S:W307	S:S:Y481	5.79	Yes	Yes	4	7	4
1063	S:S:A308	S:S:K328	3.21	No	No	0	5	6
1064	S:S:D309	S:S:K328	2.77	No	No	0	5	6
1065	S:S:D309	S:S:M469	4.16	No	No	4	5	5
1066	S:S:D309	S:S:Y481	5.75	No	Yes	4	5	4
1067	S:S:D312	S:S:R310	13.1	No	No	0	1	5
1068	S:S:R310	S:S:V313	5.23	No	No	0	5	4
1069	S:S:D480	S:S:Y311	5.75	No	No	4	1	2
1070	S:S:Y311	S:S:Y481	5.96	No	Yes	4	2	4
1071	S:S:F471	S:S:T314	5.19	Yes	Yes	4	6	3
1072	S:S:T314	S:S:Y481	4.99	Yes	Yes	4	3	4
1073	S:S:G316	S:S:Y317	2.9	No	Yes	0	3	3
1074	S:S:G316	S:S:Q318	3.29	No	No	0	3	4
1075	S:S:E320	S:S:Y317	10.1	Yes	Yes	4	4	3
1076	S:S:F471	S:S:Q318	3.51	Yes	No	4	6	4
1077	S:S:F479	S:S:Q318	14.05	No	No	4	3	4
1078	S:S:D477	S:S:R319	2.38	No	No	0	3	3
1079	S:S:A321	S:S:F471	2.77	No	Yes	0	6	6
1080	S:S:G323	S:S:V322	1.84	No	No	0	8	5
1081	S:S:G323	S:S:G324	2.11	No	No	0	8	7
1082	S:S:I325	S:S:N470	2.83	No	No	0	6	8
1083	S:S:M469	S:S:T326	3.01	No	No	0	5	6
1084	S:S:E467	S:S:K328	2.7	No	No	0	8	6
1085	S:S:L329	S:S:Y466	3.52	No	Yes	0	5	9
1086	S:S:E467	S:S:Q330	6.37	No	No	0	8	5
1087	S:S:P332	S:S:S331	1.78	No	No	0	3	5
1088	S:S:P332	S:S:S450	3.56	No	No	0	3	4
1089	S:S:V334	S:S:W336	7.36	No	Yes	0	6	5
1090	S:S:F337	S:S:Y341	10.32	Yes	Yes	3	7	6
1091	S:S:F337	S:S:Q393	7.03	Yes	Yes	3	7	5
1092	S:S:F337	S:S:M397	2.49	Yes	Yes	3	7	6
1093	S:S:D338	S:S:L342	2.71	No	Yes	3	4	4
1094	S:S:D338	S:S:H391	7.56	No	No	3	4	4
1095	S:S:D338	S:S:Q393	11.75	No	Yes	3	4	5
1096	S:S:R351	S:S:Y340	6.17	No	No	15	4	8
1097	S:S:L342	S:S:Y341	2.34	Yes	Yes	3	4	6
1098	S:S:F358	S:S:Y341	2.06	Yes	Yes	0	6	6
1099	S:S:K388	S:S:L342	8.46	No	Yes	0	3	4
1100	S:S:H391	S:S:L342	9	No	Yes	3	4	4
1101	S:S:F355	S:S:L344	3.65	Yes	No	0	4	4
1102	S:S:R345	S:S:T348	2.59	No	No	0	4	3
1103	S:S:R345	S:S:T386	3.88	No	No	0	4	4
1104	S:S:E347	S:S:P346	4.72	No	No	0	4	6
1105	S:S:F355	S:S:P346	2.89	Yes	No	2	4	6
1106	S:S:P346	S:S:W359	25.67	No	Yes	2	6	7
1107	S:S:N349	S:S:N352	4.09	No	Yes	2	4	7
1108	S:S:F355	S:S:N349	18.12	Yes	No	2	4	4
1109	S:S:N352	S:S:P353	3.26	Yes	No	2	7	3
1110	S:S:N352	S:S:W354	5.65	Yes	Yes	2	7	5
1111	S:S:F355	S:S:N352	2.42	Yes	Yes	2	4	7
1112	S:S:P353	S:S:W354	6.76	No	Yes	2	3	5
1113	S:S:F355	S:S:Q356	2.34	Yes	No	2	4	3
1114	S:S:F355	S:S:W359	4.01	Yes	Yes	2	4	7
1115	S:S:F370	S:S:Q356	22.25	No	No	2	2	3
1116	S:S:Q356	S:S:Q372	2.56	No	No	2	3	2
1117	S:S:F358	S:S:R362	2.14	Yes	No	0	6	3
1118	S:S:F363	S:S:W359	14.03	No	Yes	0	7	7
1119	S:S:L367	S:S:W359	3.42	No	Yes	0	2	7
1120	S:S:L387	S:S:W359	5.69	No	Yes	0	6	7
1121	S:S:L367	S:S:Q360	10.65	No	No	0	2	6
1122	S:S:N374	S:S:Q360	5.28	No	No	0	2	6
1123	S:S:Q360	S:S:Y377	2.25	No	Yes	0	6	1
1124	S:S:F363	S:S:R362	6.41	No	No	0	7	3
1125	S:S:L387	S:S:R362	4.86	No	No	0	6	3
1126	S:S:F363	S:S:L385	9.74	No	No	0	7	7
1127	S:S:Q364	S:S:Y377	3.38	No	Yes	0	3	1
1128	S:S:C365	S:S:C381	7.28	No	No	0	9	9
1129	S:S:E368	S:S:R366	10.47	No	No	47	1	3
1130	S:S:R366	S:S:T380	3.88	No	No	47	3	1
1131	S:S:C381	S:S:L367	4.76	No	No	0	9	2
1132	S:S:E368	S:S:T380	12.7	No	No	47	1	1
1133	S:S:F370	S:S:P371	23.12	No	No	0	2	1
1134	S:S:F370	S:S:Q372	5.86	No	No	2	2	2
1135	S:S:K376	S:S:N374	4.2	No	No	0	1	2
1136	S:S:K376	S:S:Y377	10.75	No	Yes	0	1	1
1137	S:S:N382	S:S:S384	8.94	No	No	0	5	3
1138	S:S:K388	S:S:T386	12.01	No	No	0	3	4
1139	S:S:H390	S:S:T389	5.48	No	No	0	5	1
1140	S:S:H391	S:S:Q393	2.47	No	Yes	3	4	5
1141	S:S:D394	S:S:M397	4.16	Yes	Yes	3	5	6
1142	S:S:F399	S:S:K396	3.72	No	Yes	0	7	4
1143	S:S:I401	S:S:Y405	2.42	No	No	15	8	7
1144	S:S:N402	S:S:V449	4.43	No	No	0	7	3
1145	S:S:I454	S:S:N402	7.08	No	No	0	7	7
1146	S:S:F446	S:S:Y405	3.09	Yes	No	0	8	7
1147	S:S:F446	S:S:S406	3.96	Yes	No	0	8	8
1148	S:S:F456	S:S:S406	2.64	Yes	No	0	9	8
1149	S:S:F446	S:S:Y409	9.28	Yes	No	0	8	6
1150	S:S:G410	S:S:S440	1.86	No	Yes	0	8	5
1151	S:S:G410	S:S:T444	1.82	No	No	0	8	7
1152	S:S:L411	S:S:L437	2.77	No	No	0	8	7
1153	S:S:L418	S:S:M414	4.24	No	No	0	3	5
1154	S:S:I432	S:S:M414	2.92	No	No	0	4	5
1155	S:S:M414	S:S:S440	3.07	No	Yes	0	5	5
1156	S:S:M429	S:S:Q415	2.72	No	No	0	3	4
1157	S:S:C419	S:S:P420	1.88	Yes	No	0	3	3
1158	S:S:C419	S:S:C426	7.28	Yes	No	0	3	6
1159	S:S:C419	S:S:M429	3.24	Yes	No	0	3	3
1160	S:S:G424	S:S:Y422	2.9	No	No	0	2	1
1161	S:S:K430	S:S:L425	2.82	No	No	0	1	3
1162	S:S:A428	S:S:C426	1.81	No	No	0	3	6
1163	S:S:D433	S:S:K436	13.83	No	No	0	4	7
1164	S:S:L438	S:S:R435	3.64	No	No	0	5	4
1165	S:S:L437	S:S:S440	3	No	Yes	0	7	5
1166	S:S:L437	S:S:L441	4.15	No	No	0	7	6
1167	S:S:E439	S:S:M442	4.06	No	No	0	3	5
1168	S:S:K443	S:S:M442	7.2	No	No	0	4	5
1169	S:S:F456	S:S:T444	2.59	Yes	No	0	9	7
1170	S:S:L455	S:S:N445	9.61	No	No	0	3	5
1171	S:S:F446	S:S:I454	13.82	Yes	No	0	8	7
1172	S:S:G448	S:S:I454	1.76	No	No	0	5	7
1173	S:S:D452	S:S:S450	7.36	No	No	0	5	4
1174	S:S:F456	S:S:S462	2.64	Yes	No	0	9	4
1175	S:S:D457	S:S:E458	3.9	No	No	5	7	4
1176	S:S:D457	S:S:N459	2.69	No	Yes	5	7	6
1177	S:S:D457	S:S:D461	5.32	No	Yes	5	7	8
1178	S:S:E458	S:S:N459	6.57	No	Yes	5	4	6
1179	S:S:D461	S:S:N459	2.69	Yes	Yes	5	8	6
1180	S:S:P463	S:S:S462	1.78	No	No	0	3	4
1181	S:S:P463	S:S:R465	2.88	No	No	0	3	5
1182	S:S:N489	S:S:P463	6.52	No	No	0	3	3
1183	S:S:D488	S:S:R465	7.15	No	No	0	4	5
1184	S:S:W487	S:S:Y466	2.89	Yes	Yes	0	6	9
1185	S:S:E467	S:S:N483	5.26	No	No	0	8	4
1186	S:S:G485	S:S:I468	1.76	No	No	11	9	8
1187	S:S:I468	S:S:M494	2.92	No	No	11	8	6
1188	S:S:M469	S:S:Y481	2.39	No	Yes	4	5	4
1189	S:S:K472	S:S:N470	8.39	No	No	0	6	8
1190	S:S:N470	S:S:V484	2.96	No	No	0	8	8
1191	S:S:F471	S:S:F479	6.43	Yes	No	4	6	3
1192	S:S:F471	S:S:Y481	15.47	Yes	Yes	4	6	4
1193	S:S:K472	S:S:M474	2.88	No	No	0	6	3
1194	S:S:I482	S:S:K472	4.36	No	No	0	4	6
1195	S:S:E473	S:S:F479	5.83	No	No	0	3	3
1196	S:S:G475	S:S:M474	1.75	No	No	0	3	3
1197	S:S:M474	S:S:Y478	4.79	No	No	0	3	2
1198	S:S:D480	S:S:Y481	2.3	No	Yes	4	1	4
1199	S:S:E498	S:S:I482	2.73	No	No	0	3	4
1200	S:S:E498	S:S:V484	2.85	No	No	0	3	8
1201	S:S:V484	S:S:V499	4.81	No	No	0	8	7
1202	S:S:G485	S:S:S486	1.86	No	No	0	9	2
1203	S:S:G485	S:S:M494	1.75	No	No	11	9	6
1204	S:S:G490	S:S:W487	4.22	No	Yes	0	4	6
1205	S:S:L492	S:S:W487	4.56	No	Yes	0	5	6
1206	S:S:D495	S:S:E498	2.6	No	No	0	5	3
1207	S:S:V499	S:S:W500	11.03	No	Yes	11	7	7
1208	S:S:I506	S:S:W500	8.22	No	Yes	0	4	7
1209	S:S:I507	S:S:W500	4.7	No	Yes	0	8	7
1210	S:S:R508	S:S:V510	5.23	No	No	0	1	5
1211	S:S:E513	S:S:R508	2.33	No	No	0	5	1
1212	S:S:C511	S:S:C531	7.28	No	No	27	9	9
1213	S:S:S512	S:S:W532	11.12	No	Yes	0	8	8
1214	S:S:E513	S:S:P514	7.86	No	No	0	5	6
1215	S:S:C515	S:S:Q519	3.05	No	Yes	23	9	6
1216	S:S:C515	S:S:C534	7.28	No	No	23	9	9
1217	S:S:C534	S:S:Q519	3.05	No	Yes	23	9	6
1218	S:S:P536	S:S:Q519	6.32	No	Yes	0	3	6
1219	S:S:I520	S:S:T535	4.56	No	No	0	6	4
1220	S:S:I520	S:S:V543	3.07	No	No	0	6	7
1221	S:S:C549	S:S:I520	6.55	No	No	0	9	6
1222	S:S:E546	S:S:K521	14.85	No	No	23	7	8
1223	S:S:K521	S:S:Y547	8.36	No	No	23	8	3
1224	S:S:T533	S:S:V522	3.17	No	No	0	5	5
1225	S:S:T535	S:S:V522	3.17	No	No	0	4	5
1226	S:S:I523	S:S:W532	2.35	No	Yes	0	3	8
1227	S:S:E527	S:S:R524	17.45	No	No	0	4	4
1228	S:S:R524	S:S:T533	3.88	No	No	0	4	5
1229	S:S:C534	S:S:W532	2.61	No	Yes	0	9	8
1230	S:S:P536	S:S:T535	3.5	No	No	0	3	4
1231	S:S:C537	S:S:C549	7.28	No	No	48	9	9
1232	S:S:E541	S:S:K538	5.4	Yes	No	0	7	6
1233	S:S:E539	S:S:W557	4.36	No	Yes	0	5	7
1234	S:S:E541	S:S:N540	2.63	Yes	No	0	7	8
1235	S:S:K550	S:S:Y542	9.55	No	No	0	3	7
1236	S:S:P558	S:S:Y542	2.78	Yes	No	28	8	7
1237	S:S:C565	S:S:Y542	4.03	Yes	No	28	9	7
1238	S:S:F544	S:S:T548	5.19	No	No	0	5	4
1239	S:S:F544	S:S:K550	3.72	No	No	0	5	3
1240	S:S:D545	S:S:Y547	5.75	No	No	0	7	3
1241	S:S:D545	S:S:T548	5.78	No	No	0	7	4
1242	S:S:E546	S:S:Y547	2.24	No	No	23	7	3
1243	S:S:C552	S:S:S556	6.89	No	No	28	9	5
1244	S:S:C552	S:S:P558	3.77	No	Yes	28	9	8
1245	S:S:C552	S:S:C565	7.28	No	Yes	28	9	9
1246	S:S:L554	S:S:Y723	9.38	No	No	0	4	4
1247	S:S:G555	S:S:V729	1.84	No	No	0	5	7
1248	S:S:C565	S:S:S556	5.16	Yes	No	28	9	5
1249	S:S:P558	S:S:W557	5.4	Yes	Yes	0	8	7
1250	S:S:I568	S:S:W557	2.35	No	Yes	0	8	7
1251	S:S:I726	S:S:W557	3.52	No	Yes	0	4	7
1252	S:S:C565	S:S:P558	5.65	Yes	Yes	28	9	8
1253	S:S:D560	S:S:T559	2.89	No	No	49	1	7
1254	S:S:D561	S:S:T559	7.23	No	No	49	4	7
1255	S:S:D566	S:S:T559	5.78	No	No	0	3	7
1256	S:S:D560	S:S:D561	3.99	No	No	49	1	4
1257	S:S:D561	S:S:T563	15.9	No	No	0	4	5
1258	S:S:G564	S:S:T563	1.82	No	No	0	2	5
1259	S:S:I568	S:S:P569	5.08	No	No	0	8	4
1260	S:S:H721	S:S:V570	2.77	No	No	0	2	4
1261	S:S:Q571	S:S:R574	2.34	No	No	0	6	6
1262	S:S:Q571	S:S:Y730	4.51	No	Yes	0	6	6
1263	S:S:K638	S:S:Y572	17.91	Yes	No	51	5	6
1264	S:S:L731	S:S:Y572	4.69	Yes	No	51	6	6
1265	S:S:D577	S:S:R574	5.96	Yes	No	0	7	6
1266	S:S:V584	S:S:W575	2.45	Yes	No	0	5	5
1267	S:S:I636	S:S:W575	3.52	No	No	0	8	5
1268	S:S:D577	S:S:P578	4.83	Yes	No	24	7	3
1269	S:S:D577	S:S:E579	5.2	Yes	Yes	24	7	6
1270	S:S:D577	S:S:P580	3.22	Yes	No	24	7	7
1271	S:S:E579	S:S:P578	11	Yes	No	24	6	3
1272	S:S:E579	S:S:P580	3.14	Yes	No	24	6	7
1273	S:S:E579	S:S:Y797	5.61	Yes	No	24	6	5
1274	S:S:E579	S:S:I800	4.1	Yes	No	24	6	8
1275	S:S:I636	S:S:P580	6.77	No	No	0	8	7
1276	S:S:A583	S:S:C803	1.81	No	No	0	8	7
1277	S:S:A583	S:S:F804	2.77	No	No	0	8	7
1278	S:S:F633	S:S:V584	6.55	No	Yes	0	6	5
1279	S:S:F586	S:S:S807	6.61	No	No	0	3	8
1280	S:S:F586	S:S:T811	2.59	No	No	0	3	6
1281	S:S:A587	S:S:F633	2.77	No	No	0	7	6
1282	S:S:G590	S:S:Y629	5.79	No	Yes	0	6	8
1283	S:S:L591	S:S:Y629	3.52	No	Yes	12	6	8
1284	S:S:L591	S:S:L630	4.15	No	No	12	6	6
1285	S:S:T594	S:S:Y629	3.75	No	Yes	12	7	8
1286	S:S:L814	S:S:T594	2.95	Yes	No	12	8	7
1287	S:S:L595	S:S:V599	2.98	No	No	0	3	3
1288	S:S:F596	S:S:V600	3.93	No	No	0	2	5
1289	S:S:F601	S:S:V597	3.93	No	No	12	8	6
1290	S:S:L622	S:S:V597	2.98	No	No	12	9	6
1291	S:S:F818	S:S:V597	2.62	Yes	No	12	8	6
1292	S:S:L622	S:S:T598	2.95	No	No	0	9	4
1293	S:S:I603	S:S:V599	3.07	No	No	0	3	3
1294	S:S:V600	S:S:V822	4.81	No	No	0	5	7
1295	S:S:F601	S:S:F818	8.57	No	Yes	12	8	8
1296	S:S:I603	S:S:Y604	6.04	No	No	0	3	5
1297	S:S:I825	S:S:Y604	4.84	No	No	0	8	5
1298	S:S:D606	S:S:R605	11.91	No	No	0	4	5
1299	S:S:P608	S:S:T607	5.25	No	Yes	0	7	9
1300	S:S:T607	S:S:V609	3.17	Yes	Yes	0	9	6
1301	S:S:T607	S:S:V610	4.76	Yes	No	0	9	9
1302	S:S:I825	S:S:T607	6.08	No	Yes	0	8	9
1303	S:S:S612	S:S:V609	3.23	No	Yes	0	9	6
1304	S:S:K821	S:S:V609	3.04	No	Yes	0	9	6
1305	S:S:R615	S:S:V610	6.54	No	No	0	8	9
1306	S:S:K611	S:S:R615	4.95	No	No	0	7	8
1307	S:S:S612	S:S:S613	3.26	No	Yes	18	9	9
1308	S:S:N767	S:S:S612	8.94	No	No	18	8	9
1309	S:S:K665	S:S:S613	3.06	No	Yes	18	9	9
1310	S:S:N767	S:S:S613	4.47	No	Yes	18	8	9
1311	S:S:K821	S:S:S613	4.59	No	Yes	0	9	9
1312	S:S:E616	S:S:S614	5.75	No	No	18	7	9
1313	S:S:L617	S:S:S614	7.51	Yes	No	18	8	9
1314	S:S:K665	S:S:S614	7.65	No	No	18	9	9
1315	S:S:R615	S:S:Y619	7.2	No	No	0	8	5
1316	S:S:E616	S:S:L617	3.98	No	Yes	18	7	8
1317	S:S:A661	S:S:L617	3.15	No	Yes	0	7	8
1318	S:S:K665	S:S:L617	7.05	No	Yes	18	9	8
1319	S:S:C618	S:S:F818	4.19	No	Yes	0	9	8
1320	S:S:A661	S:S:I620	3.25	No	No	0	7	6
1321	S:S:I621	S:S:I625	2.94	No	No	0	8	8
1322	S:S:I621	S:S:S658	6.19	No	No	0	8	6
1323	S:S:F818	S:S:I621	2.51	Yes	No	0	8	8
1324	S:S:F818	S:S:L622	4.87	Yes	No	12	8	9
1325	S:S:G624	S:S:M657	5.24	No	Yes	0	8	5
1326	S:S:G624	S:S:S658	1.86	No	No	0	8	6
1327	S:S:I625	S:S:Y629	6.04	No	Yes	12	8	8
1328	S:S:I625	S:S:L814	7.14	No	Yes	12	8	8
1329	S:S:G628	S:S:S654	3.71	No	No	0	6	7
1330	S:S:G628	S:S:V806	1.84	No	No	0	6	8
1331	S:S:S807	S:S:Y629	2.54	No	Yes	0	8	8
1332	S:S:A810	S:S:Y629	5.34	No	Yes	0	7	8
1333	S:S:T811	S:S:Y629	6.24	No	Yes	0	6	8
1334	S:S:L814	S:S:Y629	2.34	Yes	Yes	12	8	8
1335	S:S:C631	S:S:G650	1.96	No	No	0	7	5
1336	S:S:F633	S:S:T632	3.89	No	No	0	6	7
1337	S:S:C803	S:S:T632	5.07	No	No	0	7	7
1338	S:S:L635	S:S:Q647	7.99	No	No	0	7	8
1339	S:S:I799	S:S:L635	5.71	No	No	0	7	7
1340	S:S:A637	S:S:Y643	2.67	No	No	0	8	7
1341	S:S:K638	S:S:P639	3.35	Yes	No	0	5	9
1342	S:S:K638	S:S:L731	4.23	Yes	Yes	51	5	6
1343	S:S:C733	S:S:P639	1.88	No	No	0	9	9
1344	S:S:I642	S:S:Y643	2.42	No	No	0	4	7
1345	S:S:I642	S:S:L646	5.71	No	No	0	4	5
1346	S:S:C644	S:S:Q647	6.1	No	No	0	9	8
1347	S:S:C644	S:S:C733	7.28	No	No	52	9	9
1348	S:S:I649	S:S:Y645	4.84	Yes	No	0	5	4
1349	S:S:F712	S:S:Y645	24.76	Yes	No	53	6	4
1350	S:S:P717	S:S:Y645	2.78	No	No	53	8	4
1351	S:S:F712	S:S:R648	5.34	Yes	No	0	6	8
1352	S:S:R648	S:S:T735	3.88	No	No	0	8	6
1353	S:S:G650	S:S:I649	5.29	No	Yes	0	5	5
1354	S:S:I649	S:S:L653	2.85	Yes	Yes	0	5	6
1355	S:S:I649	S:S:I708	2.94	Yes	No	0	5	6
1356	S:S:G652	S:S:I651	1.76	No	No	0	5	7
1357	S:S:I651	S:S:M802	5.83	No	No	0	7	8
1358	S:S:G652	S:S:P655	4.06	No	Yes	0	5	8
1359	S:S:G652	S:S:P743	2.03	No	No	0	5	7
1360	S:S:L653	S:S:M657	2.83	Yes	Yes	0	6	5
1361	S:S:L653	S:S:Q704	6.65	Yes	Yes	54	6	9
1362	S:S:L653	S:S:L705	4.15	Yes	No	54	6	4
1363	S:S:P655	S:S:S654	3.56	Yes	No	25	8	7
1364	S:S:S654	X:X:?1	5.64	No	Yes	25	7	0
1365	S:S:N747	S:S:P655	6.52	No	Yes	0	7	8
1366	S:S:P655	X:X:?1	13.57	Yes	Yes	25	8	0
1367	S:S:A656	S:S:Q704	7.58	No	Yes	0	8	9
1368	S:S:A656	S:S:N747	3.13	No	No	0	8	7
1369	S:S:I701	S:S:M657	2.92	No	Yes	0	7	5
1370	S:S:S658	S:S:Y659	2.54	No	Yes	0	6	7
1371	S:S:L750	S:S:Y659	2.34	No	Yes	0	9	7
1372	S:S:I751	S:S:Y659	4.84	No	Yes	25	8	7
1373	S:S:Y659	X:X:?1	2.64	Yes	Yes	25	7	0
1374	S:S:L700	S:S:S660	4.5	No	No	0	4	9
1375	S:S:L750	S:S:S660	3	No	No	0	9	9
1376	S:S:L662	S:S:M817	2.83	No	No	0	6	8
1377	S:S:C754	S:S:V663	3.42	No	No	0	8	7
1378	S:S:Q693	S:S:T664	2.83	No	No	0	8	6
1379	S:S:T666	S:S:Y757	4.99	No	No	0	9	7
1380	S:S:N667	S:S:Y757	15.12	No	No	0	5	7
1381	S:S:I672	S:S:R668	2.51	No	No	0	9	8
1382	S:S:Q693	S:S:R668	9.35	No	No	0	8	8
1383	S:S:F687	S:S:R671	5.34	No	No	0	5	7
1384	S:S:M688	S:S:R671	6.2	No	No	0	5	7
1385	S:S:I672	S:S:M688	5.83	No	No	0	9	5
1386	S:S:A690	S:S:Q693	3.03	No	No	0	6	8
1387	S:S:F698	S:S:L694	13.4	No	No	0	3	5
1388	S:S:I699	S:S:V695	3.07	No	No	0	3	4
1389	S:S:F698	S:S:I701	2.51	No	No	0	3	7
1390	S:S:I703	S:S:L700	2.85	No	No	0	4	4
1391	S:S:I701	S:S:Q704	5.49	No	Yes	0	7	9
1392	S:S:I703	S:S:Y746	8.46	No	No	0	4	8
1393	S:S:L705	S:S:Q704	3.99	No	Yes	54	4	9
1394	S:S:Q704	S:S:Y746	4.51	Yes	No	0	9	8
1395	S:S:G706	S:S:V709	1.84	No	No	0	4	3
1396	S:S:F712	S:S:I708	2.51	Yes	No	0	6	6
1397	S:S:L711	S:S:T742	8.84	No	Yes	55	7	4
1398	S:S:L711	S:S:P743	3.28	No	No	55	7	7
1399	S:S:F712	S:S:P717	2.89	Yes	No	53	6	8
1400	S:S:E715	S:S:M714	2.71	No	No	0	5	3
1401	S:S:E715	S:S:T736	14.11	No	No	0	5	8
1402	S:S:P716	S:S:P717	1.95	No	No	0	8	8
1403	S:S:D718	S:S:I719	2.8	No	No	0	3	6
1404	S:S:D718	S:S:N734	2.69	No	No	0	3	5
1405	S:S:I719	S:S:L731	2.85	No	Yes	0	6	6
1406	S:S:H721	S:S:Y723	2.18	No	No	0	2	4
1407	S:S:H721	S:S:L731	3.86	No	Yes	0	2	6
1408	S:S:D722	S:S:P724	16.1	No	No	50	6	3
1409	S:S:D722	S:S:Y730	8.05	No	Yes	50	6	6
1410	S:S:D722	S:S:I732	5.6	No	No	0	6	6
1411	S:S:V729	S:S:Y723	7.57	No	No	0	7	4
1412	S:S:P724	S:S:Y730	4.17	No	Yes	50	3	6
1413	S:S:E728	S:S:Y730	5.61	No	Yes	0	5	6
1414	S:S:N796	S:S:Y730	4.65	No	Yes	0	5	6
1415	S:S:G739	S:S:T736	1.82	No	No	0	7	8
1416	S:S:F793	S:S:N737	4.83	No	No	0	6	3
1417	S:S:L738	S:S:T742	2.95	No	Yes	0	2	4
1418	S:S:V740	S:S:Y792	6.31	No	Yes	0	8	8
1419	S:S:P743	S:S:T742	3.5	No	Yes	55	7	4
1420	S:S:L744	X:X:?1	8.32	No	Yes	0	8	0
1421	S:S:G748	S:S:I751	1.76	No	No	25	5	8
1422	S:S:G748	X:X:?1	5.14	No	Yes	25	5	0
1423	S:S:I751	X:X:?1	4.29	No	Yes	25	8	0
1424	S:S:L752	X:X:?1	2.08	No	Yes	0	3	0
1425	S:S:F759	S:S:T755	3.89	No	No	0	8	8
1426	S:S:A758	S:S:A775	1.79	No	No	0	9	9
1427	S:S:F759	S:S:R762	4.28	No	No	0	8	9
1428	S:S:T761	S:S:V764	3.17	No	Yes	0	8	8
1429	S:S:A775	S:S:R762	5.53	No	No	0	9	9
1430	S:S:P765	S:S:V764	3.53	No	Yes	0	9	8
1431	S:S:E770	S:S:N767	10.52	No	No	0	9	8
1432	S:S:K772	S:S:N769	12.59	No	No	0	9	9
1433	S:S:E770	S:S:I774	5.47	No	No	0	9	9
1434	S:S:K772	S:S:Y773	13.14	No	No	0	9	5
1435	S:S:P820	S:S:Y773	11.13	No	No	0	9	5
1436	S:S:M817	S:S:T777	4.52	No	No	0	8	9
1437	S:S:I791	S:S:T801	4.56	No	No	0	7	8
1438	S:S:F793	S:S:Y792	10.32	No	Yes	0	6	8
1439	S:S:K798	S:S:Y792	10.75	No	Yes	0	6	8
1440	S:S:M802	S:S:Y792	3.59	No	Yes	0	8	8
1441	S:S:G794	S:S:S795	1.86	No	No	0	8	8
1442	S:S:I800	S:S:Y797	15.71	No	No	24	8	5
1443	S:S:S805	X:X:?1	5.64	No	Yes	0	8	0
1444	S:S:V806	X:X:?1	5.6	No	Yes	0	8	0
1445	S:S:S809	X:X:?1	13.54	No	Yes	0	9	0
1446	S:S:A810	X:X:?1	3.55	No	Yes	0	7	0
1447	S:S:F818	S:S:L814	4.87	Yes	Yes	12	8	8
1448	S:S:G815	S:S:V819	3.68	No	No	0	2	4
1449	S:S:F818	S:S:M817	8.71	Yes	No	0	8	8
1450	S:S:P820	S:S:V819	3.53	No	No	0	9	4
1451	S:S:V819	S:S:Y823	8.83	No	No	0	4	8
1452	R:R:G518	R:R:K517	1.74	No	No	0	9	4
1453	S:S:G526	S:S:K525	1.74	No	No	0	8	6
1454	S:S:C511	S:S:S512	1.72	No	No	0	9	8
1455	S:S:C618	S:S:S613	1.72	No	Yes	0	9	9
1456	S:S:C691	S:S:S689	1.72	No	No	0	3	7
1457	R:R:A243	R:R:S215	1.71	Yes	No	13	9	8
1458	R:R:A271	R:R:S215	1.71	No	No	13	6	8
1459	R:R:G323	R:R:L300	1.71	No	No	0	8	8
1460	R:R:C588	R:R:V584	1.71	No	Yes	0	3	5
1461	R:R:C691	R:R:V695	1.71	No	No	0	3	4
1462	R:R:G739	R:R:L711	1.71	No	No	0	7	7
1463	R:R:G739	R:R:L738	1.71	No	No	0	7	2
1464	R:R:G745	R:R:L744	1.71	No	No	0	5	8
1465	R:R:C816	R:R:V812	1.71	No	No	0	5	7
1466	S:S:G323	S:S:L300	1.71	No	Yes	0	8	8
1467	S:S:C588	S:S:V584	1.71	No	Yes	0	3	5
1468	S:S:G739	S:S:L711	1.71	No	No	0	7	7
1469	S:S:G739	S:S:L738	1.71	No	No	0	7	2
1470	S:S:G745	S:S:L744	1.71	No	No	0	5	8
1471	S:S:C816	S:S:V812	1.71	No	No	0	5	7
1472	R:R:A766	R:R:V764	1.7	No	Yes	0	7	8
1473	S:S:A766	S:S:V764	1.7	No	Yes	0	7	8
1474	S:S:A771	S:S:V764	1.7	No	Yes	0	9	8
1475	R:R:C530	R:R:T212	1.69	No	No	0	9	7
1476	R:R:I791	R:R:P790	1.69	No	No	0	7	9
1477	S:S:C530	S:S:T212	1.69	No	No	0	9	7
1478	S:S:C644	S:S:T735	1.69	No	No	52	9	6
1479	S:S:C733	S:S:T735	1.69	No	No	52	9	6
1480	S:S:C816	S:S:T777	1.69	No	No	0	5	9
1481	S:S:I791	S:S:P790	1.69	No	No	0	7	9
1482	R:R:D452	R:R:G448	1.68	No	No	0	5	5
1483	R:R:D452	R:R:G451	1.68	No	No	0	5	6
1484	R:R:A670	R:R:T761	1.68	No	No	0	6	8
1485	S:S:D452	S:S:G448	1.68	No	No	0	5	5
1486	S:S:D452	S:S:G451	1.68	No	No	0	5	6
1487	S:S:A670	S:S:T761	1.68	No	No	0	6	8
1488	R:R:L86	R:R:P87	1.64	No	No	0	9	7
1489	R:R:L367	R:R:P346	1.64	No	No	0	2	6
1490	R:R:G424	R:R:Q415	1.64	No	No	0	2	4
1491	S:S:L86	S:S:P87	1.64	No	No	0	9	7
1492	S:S:E527	S:S:G526	1.64	No	No	0	4	8
1493	R:R:N769	R:R:P765	1.63	No	No	0	9	9
1494	S:S:N769	S:S:P765	1.63	No	No	0	9	9
1495	R:R:A408	R:R:I79	1.62	No	No	0	9	9
1496	R:R:S102	R:R:V154	1.62	No	No	0	4	4
1497	R:R:A403	R:R:I147	1.62	No	No	0	9	7
1498	R:R:A403	R:R:I170	1.62	No	No	0	9	7
1499	R:R:S509	R:R:V273	1.62	No	No	0	9	8
1500	R:R:C515	R:R:K521	1.62	No	No	20	9	8
1501	R:R:C618	R:R:K665	1.62	No	Yes	0	9	9
1502	R:R:C618	R:R:K821	1.62	No	No	0	9	9
1503	R:R:S753	R:R:V663	1.62	No	No	0	4	7
1504	S:S:A408	S:S:I79	1.62	No	No	0	9	9
1505	S:S:S102	S:S:V154	1.62	No	No	0	4	4
1506	S:S:A403	S:S:I147	1.62	No	No	0	9	7
1507	S:S:A403	S:S:I170	1.62	No	No	0	9	7
1508	S:S:S509	S:S:V273	1.62	No	Yes	0	9	8
1509	S:S:C365	S:S:K379	1.62	No	No	0	9	3
1510	S:S:C515	S:S:K521	1.62	No	No	23	9	8
1511	S:S:S753	S:S:V663	1.62	No	No	0	4	7
1512	R:R:A216	R:R:M228	1.61	No	No	0	5	4
1513	S:S:A196	S:S:M234	1.61	No	No	0	3	5
1514	S:S:A199	S:S:M234	1.61	No	No	0	5	5
1515	S:S:A216	S:S:M228	1.61	No	No	0	5	4
1516	S:S:A623	S:S:M657	1.61	No	Yes	0	4	5
1517	R:R:V217	R:R:V274	1.6	No	Yes	0	5	6
1518	S:S:V217	S:S:V274	1.6	No	Yes	0	5	6
1519	R:R:G58	R:R:H45	1.59	No	No	0	3	1
1520	R:R:T607	R:R:V610	1.59	Yes	No	0	9	9
1521	R:R:C634	R:R:L646	1.59	No	No	0	5	5
1522	R:R:T742	R:R:V741	1.59	Yes	No	0	4	6
1523	S:S:G58	S:S:H45	1.59	No	No	0	3	1
1524	S:S:C419	S:S:L418	1.59	Yes	No	0	3	3
1525	S:S:C626	S:S:L591	1.59	No	No	12	4	6
1526	S:S:C626	S:S:L630	1.59	No	No	12	4	6
1527	S:S:C634	S:S:L646	1.59	No	No	0	5	5
1528	S:S:C803	S:S:L635	1.59	No	No	0	7	7
1529	S:S:T742	S:S:V741	1.59	Yes	No	0	4	6
1530	R:R:P536	R:R:Q519	1.58	No	Yes	0	3	6
1531	R:R:T559	R:R:T563	1.57	No	No	0	7	5
1532	R:R:I248	R:R:S256	1.55	No	No	0	6	3
1533	R:R:I35	R:R:V144	1.54	No	No	0	6	4
1534	R:R:I432	R:R:V144	1.54	No	No	0	4	4
1535	R:R:I581	R:R:V584	1.54	No	Yes	0	5	5
1536	R:R:I824	R:R:V609	1.54	No	Yes	0	8	6
1537	R:R:I699	R:R:V695	1.54	No	No	0	3	4
1538	R:R:I825	R:R:V822	1.54	No	Yes	0	8	7
1539	S:S:I35	S:S:V144	1.54	No	No	0	6	4
1540	S:S:I432	S:S:V144	1.54	No	No	0	4	4
1541	S:S:I581	S:S:V584	1.54	No	Yes	0	5	5
1542	S:S:I713	S:S:V709	1.54	No	No	0	3	3
1543	S:S:I825	S:S:V822	1.54	No	No	0	8	7
1544	R:R:K396	R:R:S395	1.53	Yes	No	0	4	5
1545	R:R:K493	R:R:S486	1.53	No	No	0	1	2
1546	S:S:K396	S:S:S395	1.53	Yes	No	0	4	5
1547	S:S:K493	S:S:S486	1.53	No	No	0	1	2
1548	S:S:K502	S:S:S504	1.53	No	No	0	3	4
1549	S:S:C634	S:S:Q647	1.53	No	No	0	5	8
1550	R:R:C537	R:R:E541	1.52	No	Yes	35	9	7
1551	R:R:C549	R:R:E541	1.52	No	Yes	35	9	7
1552	R:R:I602	R:R:T598	1.52	No	No	0	4	4
1553	R:R:I696	R:R:T664	1.52	No	No	0	7	6
1554	R:R:I774	R:R:T666	1.52	No	No	0	9	9
1555	R:R:I707	R:R:T742	1.52	No	Yes	0	7	4
1556	S:S:C537	S:S:E541	1.52	No	Yes	48	9	7
1557	S:S:C549	S:S:E541	1.52	No	Yes	48	9	7
1558	S:S:I602	S:S:T598	1.52	No	No	0	4	4
1559	S:S:I696	S:S:T664	1.52	No	No	0	7	6
1560	S:S:I774	S:S:T666	1.52	No	No	0	9	9
1561	S:S:I707	S:S:T742	1.52	No	Yes	0	7	4
1562	R:R:A296	R:R:E320	1.51	No	Yes	0	5	4
1563	R:R:A551	R:R:E541	1.51	No	Yes	0	4	7
1564	R:R:A690	R:R:E616	1.51	No	No	0	6	7
1565	R:R:A766	R:R:E770	1.51	No	No	0	7	9
1566	R:R:M817	R:R:T777	1.51	No	No	0	8	9
1567	S:S:A296	S:S:E320	1.51	No	Yes	0	5	4
1568	S:S:A551	S:S:E541	1.51	No	Yes	0	4	7
1569	S:S:A690	S:S:E616	1.51	No	No	0	6	7
1570	S:S:L567	S:S:S556	1.5	No	No	0	3	5
1571	S:S:K760	S:S:T761	1.5	No	No	0	7	8
1572	R:R:N374	R:R:S375	1.49	Yes	No	0	2	1
1573	R:R:N382	R:R:S383	1.49	No	No	0	5	4
1574	R:R:N413	R:R:S440	1.49	No	Yes	0	4	5
1575	R:R:L562	R:R:V543	1.49	No	No	0	6	7
1576	R:R:L673	R:R:V764	1.49	No	Yes	0	9	8
1577	R:R:L826	R:R:V822	1.49	No	Yes	0	6	7
1578	S:S:N382	S:S:S383	1.49	No	No	0	5	4
1579	S:S:N413	S:S:S440	1.49	No	Yes	0	4	5
1580	S:S:L562	S:S:V543	1.49	No	No	0	6	7
1581	S:S:L673	S:S:V764	1.49	No	Yes	0	9	8
1582	S:S:N763	S:S:V764	1.48	No	Yes	0	7	8
1583	R:R:L455	R:R:T453	1.47	No	No	0	3	3
1584	R:R:L595	R:R:T598	1.47	No	No	0	3	4
1585	R:R:I669	R:R:I672	1.47	No	No	0	9	9
1586	S:S:L455	S:S:T453	1.47	No	No	0	3	3
1587	R:R:N737	R:R:T736	1.46	No	No	0	3	8
1588	S:S:D50	S:S:T48	1.45	No	No	0	2	1
1589	R:R:K502	R:R:K503	1.44	No	No	0	3	1
1590	S:S:Q157	S:S:S102	1.44	No	No	0	5	4
1591	S:S:K638	S:S:K640	1.44	Yes	No	0	5	5
1592	S:S:E728	S:S:S725	1.44	No	No	0	5	5
1593	R:R:E238	R:R:V203	1.43	No	No	0	3	7
1594	R:R:I726	R:R:L554	1.43	No	No	0	4	4
1595	R:R:I696	R:R:L700	1.43	No	No	0	7	4
1596	S:S:Q63	S:S:V392	1.43	Yes	No	0	2	4
1597	S:S:E238	S:S:V203	1.43	No	No	0	3	7
1598	S:S:I726	S:S:L554	1.43	No	No	0	4	4
1599	R:R:K262	R:R:L293	1.41	No	No	0	3	3
1600	R:R:K436	R:R:L418	1.41	No	No	0	7	3
1601	R:R:L425	R:R:M429	1.41	No	Yes	0	3	3
1602	S:S:K262	S:S:L293	1.41	No	No	0	3	3
1603	S:S:L301	S:S:M290	1.41	No	No	0	8	4
1604	S:S:K436	S:S:L418	1.41	No	No	0	7	3
1605	S:S:L425	S:S:M429	1.41	No	No	0	3	3
1606	S:S:K517	S:S:L562	1.41	No	No	0	4	6
1607	S:S:G576	S:S:W575	1.41	No	No	0	3	5
1608	S:S:L627	S:S:M657	1.41	No	Yes	0	5	5
1609	R:R:K182	R:R:N459	1.4	No	No	0	6	6
1610	S:S:K182	S:S:N459	1.4	No	Yes	0	6	6
1611	S:S:K379	S:S:N378	1.4	No	No	0	3	1
1612	S:S:M416	S:S:N413	1.4	No	No	0	3	4
1613	R:R:P724	R:R:Y723	1.39	No	Yes	0	3	4
1614	R:R:D339	R:R:K343	1.38	No	No	0	3	4
1615	S:S:H101	S:S:V52	1.38	No	No	0	4	7
1616	S:S:D339	S:S:K343	1.38	No	No	0	3	4
1617	R:R:L385	R:R:N382	1.37	No	No	0	7	5
1618	S:S:L385	S:S:N382	1.37	No	No	0	7	5
1619	R:R:M416	R:R:Q415	1.36	No	No	0	3	4
1620	R:R:E238	R:R:K237	1.35	No	No	0	3	4
1621	S:S:E54	S:S:K51	1.35	No	No	0	1	3
1622	S:S:E238	S:S:K237	1.35	No	No	0	3	4
1623	R:R:Q157	S:S:L164	1.33	No	No	0	5	5
1624	R:R:D495	R:R:D497	1.33	No	No	0	5	4
1625	S:S:D495	S:S:D497	1.33	No	No	0	5	4
1626	R:R:D333	R:R:Q393	1.31	No	Yes	0	3	5
1627	R:R:F768	R:R:V609	1.31	No	Yes	0	9	6
1628	S:S:D333	S:S:Q393	1.31	No	Yes	0	3	5
1629	S:S:C530	S:S:W532	1.31	No	Yes	0	9	8
1630	S:S:F768	S:S:V609	1.31	No	Yes	0	9	6
1631	S:S:F756	S:S:T755	1.3	No	No	0	4	8
1632	S:S:E516	S:S:Q519	1.27	No	Yes	0	3	6
1633	S:S:S795	S:S:Y797	1.27	No	No	0	8	5
1634	R:R:V822	R:R:Y823	1.26	Yes	No	0	7	8
1635	R:R:T801	R:R:Y792	1.25	No	Yes	0	8	8
1636	S:S:T801	S:S:Y792	1.25	No	Yes	0	8	8
1637	R:R:K772	R:R:R762	1.24	No	No	0	9	9
1638	R:R:I642	R:R:Y643	1.21	Yes	No	0	4	7
1639	R:R:D477	R:R:R319	1.19	No	No	0	3	3
1640	S:S:K760	S:S:Y757	1.19	No	No	0	7	7
1641	R:R:A813	W:W:?1	1.18	No	Yes	0	7	0
1642	S:S:A813	X:X:?1	1.18	No	Yes	0	7	0
1643	R:R:I523	R:R:W532	1.17	No	Yes	0	3	8
1644	R:R:L573	R:R:Y572	1.17	No	No	0	7	6
1645	S:S:L573	S:S:Y572	1.17	No	No	0	7	6
1646	R:R:E320	R:R:R319	1.16	Yes	No	0	4	3
1647	R:R:E373	R:R:R366	1.16	No	No	0	1	3
1648	R:R:E439	R:R:R435	1.16	No	No	0	3	4
1649	S:S:E320	S:S:R319	1.16	Yes	No	0	4	3
1650	S:S:E439	S:S:R435	1.16	No	No	0	3	4
1651	S:S:D315	S:S:Y311	1.15	No	No	0	1	2
1652	R:R:D566	R:R:W557	1.12	No	Yes	0	3	7
1653	S:S:D566	S:S:W557	1.12	No	Yes	0	3	7
1654	R:R:H361	R:R:Y377	1.09	No	Yes	0	3	1
1655	R:R:R366	R:R:Y377	1.03	No	Yes	0	3	1
1656	S:S:R366	S:S:Y377	1.03	No	Yes	0	3	1
1657	S:S:R605	S:S:Y619	1.03	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:R26	3.47	4	1	3
2	R:R:F41	4.74	6	1	8
3	R:R:V43	5.085	4	1	5
4	R:R:H44	4.358	5	1	7
5	R:R:C57	4.545	4	1	8
6	R:R:Q67	3.708	5	1	7
7	R:R:R68	6.28833	6	1	4
8	R:R:E70	4.042	5	1	7
9	R:R:M72	3.25	4	1	8
10	R:R:G92	1.895	4	0	9
11	R:R:R96	11.555	4	0	4
12	R:R:C99	4.7	4	1	7
13	R:R:Q108	5.4725	4	1	5
14	R:R:I110	3.036	5	10	5
15	R:R:F112	5.4125	4	0	6
16	R:R:I143	3.205	4	0	6
17	R:R:P149	2.50667	6	0	6
18	R:R:V158	2.7125	4	6	5
19	R:R:Q159	4.874	5	6	7
20	R:R:L162	2.8675	4	6	7
21	R:R:F165	4.0075	4	10	7
22	R:R:Q169	4.4725	4	6	8
23	R:R:Y172	4.38667	6	1	7
24	R:R:M177	3.07	5	8	5
25	R:R:L179	5.894	5	6	8
26	R:R:F185	4.146	5	6	6
27	R:R:Y187	5.90667	6	6	7
28	R:R:F188	5.26	5	6	8
29	R:R:R190	4.68667	6	6	9
30	R:R:V192	3.8575	4	0	7
31	R:R:P193	3.29	4	8	8
32	R:R:D195	5.4925	4	8	8
33	R:R:Q198	5.16333	6	8	9
34	R:R:Y209	7.58667	6	16	8
35	R:R:W211	6.64	4	0	9
36	R:R:Y213	3.424	5	13	9
37	R:R:Y223	4.82667	6	8	7
38	R:R:F231	3.596	5	0	5
39	R:R:A243	3.3075	4	13	9
40	R:R:Y246	8.425	4	13	5
41	R:R:L260	3.96	4	13	5
42	R:R:V274	3.355	4	0	6
43	R:R:F277	5.17667	6	8	7
44	R:R:F299	4.9025	4	0	7
45	R:R:S304	3.8075	4	8	8
46	R:R:W307	6.534	5	7	7
47	R:R:Y317	6.78	6	19	3
48	R:R:E320	4.048	5	19	4
49	R:R:K328	2.89	4	7	6
50	R:R:F337	5.458	5	1	7
51	R:R:Y340	9.132	5	1	8
52	R:R:Y341	4.294	5	1	6
53	R:R:L342	5.305	4	1	4
54	R:R:N352	4.398	5	1	7
55	R:R:W354	4.826	5	1	5
56	R:R:F355	6.108	5	1	4
57	R:R:F358	6.79	4	1	6
58	R:R:W359	12.35	4	0	7
59	R:R:R362	3.9825	4	1	3
60	R:R:N374	3.325	4	29	2
61	R:R:Y377	3.07333	6	29	1
62	R:R:Q393	5.64	4	1	5
63	R:R:D394	5.1425	4	1	5
64	R:R:K396	3.005	4	0	4
65	R:R:M397	3.1475	4	1	6
66	R:R:M414	3.28	4	0	5
67	R:R:M429	2.565	4	0	3
68	R:R:S440	2.355	4	0	5
69	R:R:F446	7.4825	4	0	8
70	R:R:F456	2.6225	4	0	9
71	R:R:D461	5.8575	4	6	8
72	R:R:Y466	4.146	5	8	9
73	R:R:M469	3.11	4	7	5
74	R:R:F471	6.414	5	7	6
75	R:R:Y481	5.95	7	7	4
76	R:R:W487	5.16	6	0	6
77	R:R:W500	8.6025	4	16	7
78	R:R:Q519	4.595	4	20	6
79	R:R:W532	4.6875	4	0	8
80	R:R:E541	3.582	5	35	7
81	R:R:W557	3.775	4	0	7
82	R:R:P558	4.605	4	26	8
83	R:R:C565	5.195	4	26	9
84	R:R:E579	5.21	4	37	6
85	R:R:V584	3.0625	4	0	5
86	R:R:T607	4.868	5	38	9
87	R:R:V609	2.458	5	0	6
88	R:R:S613	3.845	4	21	9
89	R:R:Y629	4.12125	8	17	8
90	R:R:F633	3.9125	4	0	6
91	R:R:I642	4.2275	4	39	4
92	R:R:Y645	7.3975	4	39	4
93	R:R:L653	3.4675	4	40	6
94	R:R:P655	6.62	4	14	8
95	R:R:M657	3.0175	4	0	5
96	R:R:Y659	3.49	4	14	7
97	R:R:K665	4.845	4	21	9
98	R:R:Q704	5.35333	6	40	9
99	R:R:Y723	5.13	4	0	4
100	R:R:Y730	5.345	4	36	6
101	R:R:T742	4.566	5	41	4
102	R:R:V764	2.4725	4	0	8
103	R:R:Y792	6.444	5	0	8
104	R:R:L814	4.375	4	17	8
105	R:R:F818	5.23167	6	17	8
106	R:R:V822	2.275	4	0	7
107	S:S:R26	3.47	4	2	3
108	S:S:F41	4.74	6	3	8
109	S:S:V43	5.085	4	2	5
110	S:S:H44	4.928	5	2	7
111	S:S:C57	4.9125	4	2	8
112	S:S:Q63	3.2475	4	3	2
113	S:S:Q67	4.22	5	3	7
114	S:S:R68	6.28833	6	3	4
115	S:S:E70	4.4925	4	0	7
116	S:S:M72	3.166	5	3	8
117	S:S:G92	1.895	4	0	9
118	S:S:R96	11.7875	4	0	4
119	S:S:Q108	5.765	4	2	5
120	S:S:I110	3.286	5	10	5
121	S:S:F112	5.146	5	22	6
122	S:S:I113	3.125	4	10	6
123	S:S:R114	5.646	5	0	7
124	S:S:I143	3.205	4	22	6
125	S:S:P149	2.81833	6	0	6
126	S:S:V158	3.52	4	5	5
127	S:S:Q159	4.874	5	5	7
128	S:S:L162	3.24	4	5	7
129	S:S:F165	3.694	5	10	7
130	S:S:Q169	4.4725	4	5	8
131	S:S:Y172	4.38667	6	3	7
132	S:S:M177	3.07	5	9	5
133	S:S:L179	5.894	5	5	8
134	S:S:F185	4.146	5	5	6
135	S:S:Y187	5.90667	6	5	7
136	S:S:F188	5.26	5	5	8
137	S:S:R190	4.68667	6	5	9
138	S:S:V192	4.625	4	0	7
139	S:S:P193	3.73	4	9	8
140	S:S:D195	5.4925	4	9	8
141	S:S:Q198	5.36	6	9	9
142	S:S:Y209	6.94333	6	11	8
143	S:S:W211	5.85	4	11	9
144	S:S:Y213	3.694	5	27	9
145	S:S:Y223	5.68667	6	9	7
146	S:S:F231	3.596	5	0	5
147	S:S:Y246	6.656	5	42	5
148	S:S:L260	3.27	4	42	5
149	S:S:V273	4.405	4	11	8
150	S:S:V274	3.0275	4	0	6
151	S:S:F277	6.982	5	9	7
152	S:S:L287	3.105	4	4	4
153	S:S:E298	6.395	4	46	3
154	S:S:L300	2.74	4	11	8
155	S:S:S304	3.8075	4	9	8
156	S:S:W307	7.018	5	4	7
157	S:S:T314	4.1925	4	4	3
158	S:S:Y317	7.26833	6	4	3
159	S:S:E320	4.746	5	4	4
160	S:S:W336	5.74	4	15	5
161	S:S:F337	5.458	5	3	7
162	S:S:Y341	4.294	5	3	6
163	S:S:L342	5.6275	4	3	4
164	S:S:N352	4.398	5	2	7
165	S:S:W354	4.826	5	2	5
166	S:S:F355	5.57167	6	2	4
167	S:S:F358	6.79	4	0	6
168	S:S:W359	10.564	5	2	7
169	S:S:Y377	4.3525	4	0	1
170	S:S:Q393	5.64	4	3	5
171	S:S:D394	4.1625	4	3	5
172	S:S:K396	3.005	4	0	4
173	S:S:M397	3.1475	4	3	6
174	S:S:C419	3.4975	4	0	3
175	S:S:S440	2.355	4	0	5
176	S:S:F446	7.5375	4	0	8
177	S:S:F456	2.6225	4	0	9
178	S:S:N459	3.3375	4	5	6
179	S:S:D461	5.8575	4	5	8
180	S:S:Y466	4.146	5	9	9
181	S:S:F471	6.674	5	4	6
182	S:S:Y481	6.09286	7	4	4
183	S:S:W487	5.16	6	0	6
184	S:S:W500	8.4	4	11	7
185	S:S:Q519	3.4225	4	23	6
186	S:S:W532	4.3475	4	0	8
187	S:S:E541	2.516	5	48	7
188	S:S:W557	3.35	5	0	7
189	S:S:P558	4.4	4	28	8
190	S:S:C565	5.53	4	28	9
191	S:S:D577	4.8025	4	24	7
192	S:S:E579	5.81	5	24	6
193	S:S:V584	3.0625	4	0	5
194	S:S:T607	4.815	4	0	9
195	S:S:V609	2.6875	4	0	6
196	S:S:S613	3.42	5	18	9
197	S:S:L617	5.4225	4	18	8
198	S:S:Y629	4.445	8	12	8
199	S:S:K638	6.7325	4	51	5
200	S:S:I649	3.98	4	0	5
201	S:S:L653	4.12	4	54	6
202	S:S:P655	6.9275	4	25	8
203	S:S:M657	2.802	5	0	5
204	S:S:Y659	3.09	4	25	7
205	S:S:Q704	5.644	5	54	9
206	S:S:F712	8.875	4	53	6
207	S:S:Y730	5.398	5	50	6
208	S:S:L731	3.9075	4	51	6
209	S:S:T742	3.68	5	55	4
210	S:S:V764	2.17833	6	0	8
211	S:S:Y792	6.444	5	0	8
212	S:S:L814	4.325	4	12	8
213	S:S:F818	5.19143	7	12	8
214	X:X:?1	5.9325	12	25	0
215	W:W:?1	5.65833	12	14	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L161	R:R:S109	94.2917	3	No	No	0	5	6
2	R:R:S109	R:R:V158	94.2729	3.23	No	Yes	0	6	5
3	R:R:I110	R:R:L161	94.0193	4.28	Yes	No	0	5	5
4	R:R:I110	S:S:R114	99.5333	2.51	Yes	Yes	0	5	7
5	S:S:Q108	S:S:R96	50.1098	15.19	Yes	Yes	0	5	4
6	S:S:E111	S:S:R96	100	5.82	No	Yes	0	3	4
7	S:S:E111	S:S:R114	99.9835	4.65	No	Yes	0	3	7
8	R:R:F188	R:R:Q169	87.5578	4.68	Yes	Yes	6	8	8
9	R:R:Q169	R:R:V158	87.8589	2.87	Yes	Yes	6	8	5
10	R:R:F188	R:R:R190	87.6853	3.21	Yes	Yes	6	8	9
11	R:R:R190	R:R:V192	46.6399	2.62	Yes	Yes	0	9	7
12	R:R:T175	R:R:V192	41.2989	3.17	No	Yes	0	8	7
13	R:R:D195	R:R:T175	41.2556	7.23	Yes	No	0	8	8
14	R:R:D195	R:R:M177	38.2929	2.77	Yes	Yes	8	8	5
15	R:R:M177	R:R:S194	41.2032	3.07	Yes	No	0	5	8
16	R:R:R190	R:R:S194	41.2457	3.95	Yes	No	0	9	8
17	R:R:D195	R:R:Y223	73.6944	8.05	Yes	Yes	8	8	7
18	R:R:F277	R:R:M202	16.0411	2.49	Yes	No	0	7	6
19	R:R:A243	R:R:S215	31.0165	1.71	Yes	No	13	9	8
20	R:R:L264	R:R:S215	62.0237	3	No	No	13	7	8
21	R:R:L260	R:R:L264	62.0876	4.15	Yes	No	13	5	7
22	R:R:I248	R:R:L260	62.7304	2.85	No	Yes	0	6	5
23	R:R:F257	R:R:I248	63.1336	3.77	No	No	0	4	6
24	R:R:F257	R:R:G285	63.2343	4.52	No	No	0	4	1
25	R:R:G285	R:R:M288	63.335	1.75	No	No	0	1	3
26	R:R:M288	R:R:R284	62.9698	3.72	No	No	19	3	2
27	R:R:M281	R:R:R284	68.4256	2.48	No	No	0	2	2
28	R:R:M281	R:R:S250	68.5246	3.07	No	No	0	2	3
29	R:R:E279	R:R:S250	68.5537	2.87	No	No	0	4	3
30	R:R:E279	R:R:Y223	68.6516	2.24	No	Yes	0	4	7
31	R:R:A243	R:R:Y213	30.8049	5.34	Yes	Yes	13	9	9
32	R:R:A271	R:R:S215	30.9061	1.71	No	No	13	6	8
33	R:R:A271	R:R:Y213	30.8003	2.67	No	Yes	13	6	9
34	R:R:C531	R:R:Y213	60.9519	2.69	No	Yes	13	9	9
35	R:R:C241	R:R:V528	60.0955	3.42	No	No	0	9	6
36	R:R:E527	R:R:V528	60.3119	8.56	No	No	0	4	6
37	R:R:C531	R:R:E527	60.7447	3.04	No	No	0	9	4
38	R:R:C241	R:R:C530	59.879	3.64	No	No	0	9	9
39	R:R:C530	R:R:W532	59.446	2.61	No	Yes	0	9	8
40	R:R:C515	R:R:C534	55.2637	7.28	No	No	20	9	9
41	R:R:C534	R:R:W532	58.7962	2.61	No	Yes	0	9	8
42	R:R:C515	R:R:K521	55.1084	1.62	No	No	20	9	8
43	R:R:K521	R:R:Y547	54.6698	7.17	No	No	20	8	3
44	R:R:F544	R:R:K550	53.8045	2.48	No	No	0	5	3
45	R:R:F544	R:R:T548	54.0219	3.89	No	No	0	5	4
46	R:R:D545	R:R:T548	54.2393	5.78	No	No	0	7	4
47	R:R:D545	R:R:Y547	54.4566	6.9	No	No	0	7	3
48	R:R:K550	R:R:Y542	53.5871	8.36	No	No	0	3	7
49	R:R:P558	R:R:Y542	52.7053	2.78	Yes	No	26	8	7
50	R:R:I726	R:R:L554	50.1038	1.43	No	No	0	4	4
51	R:R:I726	R:R:W557	50.3218	3.52	No	Yes	0	4	7
52	R:R:P558	R:R:W557	52.2819	8.11	Yes	Yes	0	8	7
53	R:R:L554	R:R:Y723	49.8859	9.38	No	Yes	0	4	4
54	R:R:H721	R:R:Y723	47.2675	2.18	No	Yes	0	2	4
55	R:R:K638	R:R:Y572	45.5192	7.17	No	No	0	5	6
56	R:R:L731	R:R:Y572	45.9565	4.69	No	No	0	6	6
57	R:R:H721	R:R:L731	46.8306	2.57	No	No	0	2	6
58	R:R:A810	R:R:Y629	23.9336	4	No	Yes	0	7	8
59	R:R:A810	W:W:?1	24.1555	2.37	No	Yes	0	7	0
60	R:R:P655	W:W:?1	27.4421	12.34	Yes	Yes	14	8	0
61	R:R:N747	R:R:P655	32.748	6.52	No	Yes	0	7	8
62	R:R:N747	R:R:Y746	32.9686	2.33	No	No	0	7	8
63	R:R:Q704	R:R:Y746	36.9663	4.51	Yes	No	0	9	8
64	R:R:I708	R:R:Q704	40.9201	4.12	No	Yes	0	6	9
65	R:R:F712	R:R:I708	41.1394	3.77	No	No	0	6	6
66	R:R:F712	R:R:R648	43.331	5.34	No	No	0	6	8
67	R:R:C644	R:R:R648	43.7689	2.79	No	No	0	9	8
68	R:R:C644	R:R:C733	44.6443	7.28	No	No	0	9	9
69	R:R:C733	R:R:P639	44.8631	1.88	No	No	0	9	9
70	R:R:K638	R:R:P639	45.0818	3.35	No	No	0	5	9
71	R:R:L814	R:R:Y629	16.5901	2.34	Yes	Yes	17	8	8
72	R:R:C618	R:R:F818	13.6907	4.19	No	Yes	0	9	8
73	R:R:F818	R:R:L814	16.3695	3.65	Yes	Yes	17	8	8
74	S:S:F112	S:S:R96	49.9077	11.76	Yes	Yes	0	6	4
75	S:S:L40	S:S:Q108	47.8233	2.66	No	Yes	0	6	5
76	S:S:L40	S:S:V146	95.3536	2.98	No	No	0	6	7
77	S:S:L162	S:S:V146	95.3096	4.47	Yes	No	0	7	7
78	S:S:L162	S:S:Q169	92.528	2.66	Yes	Yes	5	7	8
79	S:S:F188	S:S:Q169	91.4328	4.68	Yes	Yes	5	8	8
80	S:S:F188	S:S:R190	90.9739	3.21	Yes	Yes	5	8	9
81	S:S:R190	S:S:V192	49.877	2.62	Yes	Yes	0	9	7
82	S:S:F112	S:S:L40	47.6237	2.44	Yes	No	0	6	6
83	S:S:T175	S:S:V192	43.3988	3.17	No	Yes	0	8	7
84	S:S:D195	S:S:T175	43.336	7.23	Yes	No	0	8	8
85	S:S:R190	S:S:S194	41.0472	3.95	Yes	No	0	9	8
86	S:S:M177	S:S:S194	40.9847	3.07	Yes	No	0	5	8
87	S:S:D195	S:S:M177	40.5548	2.77	Yes	Yes	9	8	5
88	S:S:D195	S:S:Y223	83.1228	8.05	Yes	Yes	9	8	7
89	S:S:E279	S:S:Y223	82.9239	2.24	No	Yes	0	4	7
90	S:S:E279	S:S:S250	82.7917	2.87	No	No	0	4	3
91	S:S:M281	S:S:S250	77.3937	3.07	No	No	0	2	3
92	S:S:M281	S:S:R284	77.2598	2.48	No	No	0	2	2
93	S:S:M288	S:S:R284	72.127	2.48	No	No	4	3	2
94	S:S:G285	S:S:M288	72.2836	1.75	No	No	0	1	3
95	S:S:F257	S:S:G285	72.1485	4.52	No	No	0	4	1
96	S:S:F257	S:S:I248	72.0134	3.77	No	No	0	4	6
97	S:S:I248	S:S:L260	71.8782	2.85	No	Yes	0	6	5
98	S:S:L260	S:S:Y246	71.3207	4.69	Yes	Yes	42	5	5
99	S:S:H267	S:S:Y246	70.7955	2.18	No	Yes	0	3	5
100	S:S:A243	S:S:H267	70.66	2.93	No	No	0	9	3
101	S:S:A243	S:S:Y213	70.3809	5.34	No	Yes	27	9	9
102	S:S:C511	S:S:Y213	69.9741	5.38	No	Yes	27	9	9
103	S:S:C511	S:S:S512	69.8465	1.72	No	No	0	9	8
104	S:S:S512	S:S:W532	69.7107	11.12	No	Yes	0	8	8
105	S:S:C534	S:S:W532	68.8958	2.61	No	Yes	0	9	8
106	S:S:C515	S:S:C534	65.8829	7.28	No	No	23	9	9
107	S:S:C515	S:S:K521	65.8974	1.62	No	No	23	9	8
108	S:S:K521	S:S:Y547	65.6165	8.36	No	No	23	8	3
109	S:S:D545	S:S:Y547	65.4873	5.75	No	No	0	7	3
110	S:S:D545	S:S:T548	65.3505	5.78	No	No	0	7	4
111	S:S:F544	S:S:T548	65.2137	5.19	No	No	0	5	4
112	S:S:F544	S:S:K550	65.0769	3.72	No	No	0	5	3
113	S:S:K550	S:S:Y542	64.94	9.55	No	No	0	3	7
114	S:S:P558	S:S:Y542	64.2258	2.78	Yes	No	28	8	7
115	S:S:P558	S:S:W557	63.9883	5.4	Yes	Yes	0	8	7
116	S:S:I726	S:S:W557	62.6154	3.52	No	Yes	0	4	7
117	S:S:I726	S:S:L554	62.4779	1.43	No	No	0	4	4
118	S:S:L554	S:S:Y723	62.3404	9.38	No	No	0	4	4
119	S:S:H721	S:S:Y723	61.9276	2.18	No	No	0	2	4
120	S:S:H721	S:S:L731	61.6523	3.86	No	Yes	0	2	6
121	S:S:K638	S:S:L731	60.8117	4.23	Yes	Yes	51	5	6
122	S:S:K638	S:S:P639	60.5497	3.35	Yes	No	0	5	9
123	S:S:C733	S:S:P639	60.4117	1.88	No	No	0	9	9
124	S:S:C733	S:S:T735	54.6231	1.69	No	No	52	9	6
125	S:S:R648	S:S:T735	54.7264	3.88	No	No	0	8	6
126	S:S:F712	S:S:R648	54.587	5.34	Yes	No	0	6	8
127	S:S:F712	S:S:Y645	27.0782	24.76	Yes	No	53	6	4
128	S:S:I649	S:S:Y645	26.9418	4.84	Yes	No	0	5	4
129	S:S:I649	S:S:L653	53.0128	2.85	Yes	Yes	0	5	6
130	S:S:L653	S:S:M657	39.6248	2.83	Yes	Yes	0	6	5
131	S:S:G624	S:S:M657	37.8949	5.24	No	Yes	0	8	5
132	S:S:G624	S:S:S658	37.6059	1.86	No	No	0	8	6
133	S:S:I621	S:S:S658	33.3052	6.19	No	No	0	8	6
134	S:S:F712	S:S:I708	27.0783	2.51	Yes	No	0	6	6
135	S:S:I649	S:S:I708	26.9357	2.94	Yes	No	0	5	6
136	S:S:F818	S:S:I621	29.2271	2.51	Yes	No	0	8	8
137	S:S:C618	S:S:F818	25.515	4.19	No	Yes	0	9	8
138	S:S:C618	S:S:S613	25.2232	1.72	No	Yes	0	9	9
139	S:S:L653	S:S:Q704	12.8235	6.65	Yes	Yes	54	6	9
140	S:S:A656	S:S:Q704	10.497	7.58	No	Yes	0	8	9
141	S:S:A656	S:S:N747	10.2062	3.13	No	No	0	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:G628	S:S:S654	3.71	0	No	No	6	7	2	1
S:S:G628	S:S:V806	1.84	0	No	No	6	8	2	1
S:S:A810	S:S:Y629	5.34	0	No	Yes	7	8	1	2
S:S:G652	S:S:P655	4.06	0	No	Yes	5	8	2	1
S:S:P655	S:S:S654	3.56	25	Yes	No	8	7	1	1
S:S:S654	X:X:?1	5.64	25	No	Yes	7	0	1	0
S:S:N747	S:S:P655	6.52	0	No	Yes	7	8	2	1
S:S:P655	X:X:?1	13.57	25	Yes	Yes	8	0	1	0
S:S:S658	S:S:Y659	2.54	0	No	Yes	6	7	2	1
S:S:L750	S:S:Y659	2.34	0	No	Yes	9	7	2	1
S:S:I751	S:S:Y659	4.84	25	No	Yes	8	7	1	1
S:S:Y659	X:X:?1	2.64	25	Yes	Yes	7	0	1	0
S:S:L744	X:X:?1	8.32	0	No	Yes	8	0	1	0
S:S:G748	S:S:I751	1.76	25	No	No	5	8	1	1
S:S:G748	X:X:?1	5.14	25	No	Yes	5	0	1	0
S:S:I751	X:X:?1	4.29	25	No	Yes	8	0	1	0
S:S:L752	X:X:?1	2.08	0	No	Yes	3	0	1	0
S:S:S805	X:X:?1	5.64	0	No	Yes	8	0	1	0
S:S:V806	X:X:?1	5.6	0	No	Yes	8	0	1	0
S:S:S809	X:X:?1	13.54	0	No	Yes	9	0	1	0
S:S:A810	X:X:?1	3.55	0	No	Yes	7	0	1	0
S:S:G745	S:S:L744	1.71	0	No	No	5	8	2	1
S:S:A813	X:X:?1	1.18	0	No	Yes	7	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
50.00	Single	8X0B	VU0424465	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
50.00	Single	8X0C	VU0424465	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
50.00	Single	8X0C	VU0424465	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
47.06	Single	4OO9	Mavoglurant	4OO9-mGlu₅-Mavoglurant
47.06	Single	7P2L	4YI	7P2L-mGlu₅-4YI
47.06	Single	8TAO	CDPPB	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
46.67	Single	6FFI	MMPEP	6FFI-mGlu₅-MMPEP
43.75	Single	6FFH	Fenobam	6FFH-mGlu₅-Fenobam
42.11	Single	5CGD	HTL14242	5CGD-mGlu₅-HTL14242
41.18	Single	8X0D	VU0424465	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
41.18	Single	8X0D	VU0424465	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
38.89	Single	8X0B	VU0424465	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
33.33	Single	5CGC	HTL14242	5CGC-mGlu₅-HTL14242
31.58	Single	8X0F	VU0424465	8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
28.00	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
23.81	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
23.81	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
22.73	Single	8J19	LY237	8J19-GPR84-LY237-Gi1/β1/γ2
22.73	Single	8XVJ	Macitentan	8XVJ-ET_A-Macitentan
22.22	Single	8PM2	DMCH	8PM2-TA7-DMCH-Gs/β1/γ2
21.74	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05	Single	4U16	N-Methyl-Scopolamine	4U16-M₃-N-Methyl-Scopolamine
21.05	Single	5DSG	Tiotropium	5DSG-M₄-Tiotropium
21.05	Consensus	m4_off	Orthosteric Ligand	5DSG-M₄-Tiotropium
20.83	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
20.00	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
20.00	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
20.00	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
20.00	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/β1/γ2
20.00	Single	8E9Z	Iperoxo	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/β1/γ2
20.00	Consensus	gq_muscarinic	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
20.00	Consensus	m1_on	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
20.00	Consensus	m2_off	Orthosteric Ligand	5ZKC-M₂-N-Methyl-Scopolamine 5ZK3-M₂-3-quinuclidinyl-benzilate 5ZKB-M₂-AF-DX 384
19.05	Single	5V54	Methiothepin	5V54-5-HT_1B-Methiothepin
19.05	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
19.05	Single	6OIJ	Iperoxo	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
19.05	Single	7TRQ	Iperoxo	7TRQ-M₄-Iperoxo-VU0467154-Gi1/β1/γ2
19.05	Single	8EA0	Iperoxo	8EA0-M₃-Iperoxo
19.05	Single	8IUK	PGF2-alpha	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
19.05	Single	8JXX	Clobenpropit	8JXX-H₄-Clobenpropit-Gi1/β1/γ2
19.05	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/β1/γ2
19.05	Consensus	5ht1_off	Orthosteric Ligand	5ht1b_off
19.05	Consensus	5ht1b_off	Orthosteric Ligand	5V54-5-HT_1B-Methiothepin
19.05	Consensus	5ht_off	Orthosteric Ligand	5ht2_off 5ht1_off
19.05	Consensus	h4_on_gp	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2 8JXX-H₄-Clobenpropit-Gi1/β1/γ2
19.05	Consensus	m1_on_gp	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
19.05	Consensus	muscarinic_off	Orthosteric Ligand	m2_off m3_off m4_off m5_off m1_off
18.75	Single	8IW7	2-Phenylethylamine	8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
18.75	Single	8YN9	Histamine	8YN9-H₄-Histamine-Gi1/β1/γ2
18.75	Single	8YUU	Histamine	8YUU-H₃-Histamine-Gi1/β1/γ1
18.75	Consensus	h3_on	Orthosteric Ligand	8YUU-H₃-Histamine-Gi1/β1/γ1
18.75	Consensus	h3_on_gp	Orthosteric Ligand	8YUU-H₃-Histamine-Gi1/β1/γ1
18.18	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
18.18	Single	5CXV	Tiotropium	5CXV-M₁-Tiotropium
18.18	Single	5X33	BIIL260	5X33-BLT₁-BIIL260
18.18	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
18.18	Single	7WCM	MBX-2982	7WCM-GPR119-MBX-2982-Gs/β1/γ2
18.18	Single	7WCN	AR231453	7WCN-GPR119-AR231453-Gs/β1/γ2
18.18	Single	8E9W	2-Deoxycytidine	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18	Consensus	m1_off	Orthosteric Ligand	5CXV-M₁-Tiotropium
17.65	Single	7YFD	Imetit	7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65	Single	8HN8	Histamine	8HN8-H₄-Histamine-Gi1/β1/γ2
17.65	Single	8Y0N	VUF11418	8Y0N-CXCR3-VUF11418-Go1/β1/γ2
17.65	Single	8YN5	Histamine	8YN5-H₃-Histamine-Gi1/β1/γ2
17.65	Single	8YN6	Imetit	8YN6-H₃-Imetit-Gi1/β1/γ2
17.65	Single	8YN7	Immethridine	8YN7-H₃-Immethridine-Go1/β1/γ2
17.65	Single	8YUV	Immepip	8YUV-H₃-Immepip-Gi1/β1/γ2
17.65	Single	9EPR	Retinal	9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
17.65	Consensus	h4_on	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2 8JXX-H₄-Clobenpropit-Gi1/β1/γ2
17.39	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
17.39	Single	6BQH	Ritanserin	6BQH-5-HT_2C-Ritanserin
17.39	Single	6K1Q	IRL2500	6K1Q-ET_B-IRL2500
17.39	Single	7U2K	C6-guano	7U2K-μ-C6-guano-Gi1/β1/γ2
17.39	Single	7XZ6	APD668	7XZ6-GPR119-APD668-Gs/β1/γ2
17.39	Consensus	5ht2c_off	Orthosteric Ligand	6BQH-5-HT_2C-Ritanserin
17.39	Consensus	fp-alpha_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39	Consensus	fp-alpha_on_gp	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/β1/γ2
16.67	Single	6PT3	DPI-287	6PT3-δ-DPI-287
16.67	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
16.67	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/β1/γ2
16.67	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/β1/γ2
16.67	Single	7EJ0	L-Norepinephrine	7EJ0-α_2a-L-Norepinephrine-Go/β1/γ2
16.67	Single	7T8X	Acetylcholine	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.67	Single	7T90	Acetylcholine	7T90-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.67	Single	7T96	Acetylcholine	7T96-M₂-Acetylcholine-LY2119620-Go/β1/γ2
16.67	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
16.67	Single	7VVO	PTH	7VVO-PTH1-PTH-Gs/β1/γ2
16.67	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/β1/γ2
16.67	Single	8HOC	Imetit	8HOC-H₄-Imetit-Gi1/β1/γ2
16.67	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67	Single	8IW4	Spermidine	8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
16.67	Single	8IWE	Spermidine	8IWE-TA9-Spermidine
16.67	Single	8Y0H	VUF11418	8Y0H-CXCR3-VUF11418
16.67	Single	8YNA	Immepip	8YNA-H₄-Immepip-Gi1/β1/γ
16.67	Consensus	histamine_on	Orthosteric Ligand	h1_on h2_on h3_on h4_on
16.67	Consensus	histamine_on_gp	Orthosteric Ligand	h1_on_gp h2_on_gp h3_on_gp h4_on_gp
16.67	Consensus	m2_on	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.67	Consensus	m2_on_gp	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.00	Single	7QA8	Peptide	7QA8-STE2-Peptide
16.00	Single	7QA8	Peptide	7QA8-STE2-Peptide
15.79	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
15.79	Single	7CMV	PD128907	7CMV-D₃-PD128907-Gi1/β1/γ2
15.79	Single	7T94	Acetylcholine	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
15.79	Single	7TRS	Acetylcholine	7TRS-M₄-Acetylcholine-Gi1/β1/γ2
15.79	Single	8DPG	Psilocin	8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79	Single	8HNM	VUF11222	8HNM-CXCR3-VUF11222-Gi1/β1/γ2
15.79	Single	8Y01	Retinal	8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
15.79	Single	8YN8	Proxyfan	8YN8-H₃-Proxyfan-Go1/β1/γ2
15.79	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
15.15	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
15.15	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
15.00	Single	4DAJ	Tiotropium	4DAJ-M₃-Tiotropium
15.00	Single	5YC8	N-Methyl-Scopolamine	5YC8-M₂-N-Methyl-Scopolamine
15.00	Single	5ZK8	N-Methyl-Scopolamine	5ZK8-M₂-N-Methyl-Scopolamine
15.00	Single	5ZKC	N-Methyl-Scopolamine	5ZKC-M₂-N-Methyl-Scopolamine
15.00	Single	6TOT	Lemborexant	6TOT-OX₁-Lemborexant
15.00	Single	6WHA	DB13948	6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
15.00	Single	7UM5	5-CT	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/β1/γ2
15.00	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/β1/γ2
15.00	Single	8T1W	CVN424	8T1W-GPR6-CVN424
15.00	Single	8X64	Desloratadine	8X64-H₁-Desloratadine
15.00	Single	8X9T	AP503	8X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
15.00	Consensus	gi_histamine	Orthosteric Ligand	8JXX-H₄-Clobenpropit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8YUU-H₃-Histamine-Gi1/β1/γ1 8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2
15.00	Consensus	muscarinic_on	Orthosteric Ligand	m2_on m3_on m4_on m1_on
15.00	Consensus	muscarinic_on_gp	Orthosteric Ligand	m2_on_gp m3_on_gp m4_on_gp m1_on_gp
14.81	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
14.29	Single	4WW3	All-trans-Retinal	4WW3-Rhodopsin-All-trans-Retinal
14.29	Single	4ZJ8	Suvorexant	4ZJ8-OX₁-Suvorexant
14.29	Single	5JQH	S-Carazolol	5JQH-β₂-S-Carazolol
14.29	Single	5ZK3	3-quinuclidinyl-benzilate	5ZK3-M₂-3-quinuclidinyl-benzilate
14.29	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/β1/γ1
14.29	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
14.29	Single	6OIK	Iperoxo	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
14.29	Single	6PS6	Timolol	6PS6-β₂-Timolol
14.29	Single	6TO7	Suvorexant	6TO7-OX₁-Suvorexant-Na
14.29	Single	6TP6	Filorexant	6TP6-OX₁-Filorexant
14.29	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
14.29	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
14.29	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
14.29	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/β1/γ2
14.29	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29	Single	7TRK	Iperoxo	7TRK-M₄-Iperoxo-Gi1/β1/γ2
14.29	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/β1/γ2
14.29	Single	8EFB	Oliceridine	8EFB-μ-Oliceridine-Gi1/β1/γ2
14.29	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
14.29	Single	8J18	(3R)-3-Hydroxydodecanoic acid	8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
14.29	Single	8YNS	SNAP-94847	8YNS-MCH1-SNAP-94847
14.29	Single	8ZMF	A1L10	8ZMF-5-HT_2C-A1L10
14.29	Single	8ZRK	GSK-1292263	8ZRK-GPR119-GSK-1292263-Gs/β1/γ2
14.29	Single	9JR3	PTH	9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29	Consensus	m3_on	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29	Consensus	m3_on_gp	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/β1/γ2
13.64	Single	2YDV	NECA	2YDV-A_2A-NECA
13.64	Single	3UON	3-quinuclidinyl-benzilate	3UON-M₂-3-quinuclidinyl-benzilate
13.64	Single	4U15	Tiotropium	4U15-M₃-Tiotropium
13.64	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
13.64	Single	5G53	NECA	5G53-A_2A-NECA-Gs
13.64	Single	5ZKB	AF-DX 384	5ZKB-M₂-AF-DX 384
13.64	Single	6OL9	Tiotropium	6OL9-M₅-Tiotropium
13.64	Single	7EW4	CYM5541	7EW4-S1P₃-CYM5541-Gi1/β1/γ2
13.64	Single	7T2H	Lofentanil	7T2H-μ-Lofentanil-Gi1/β1/γ2
13.64	Single	7U2L	PubChem 163201242	7U2L-μ-PubChem 163201242-Gi1/β1/γ2
13.64	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2
13.64	Single	8EF5	Fentanyl	8EF5-μ-Fentanyl-Gi1/β1/γ2
13.64	Single	8IRU	Rotigotine	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.64	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/β1/γ2
13.64	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/β1/γ2
13.64	Single	8T1V	PubChem 118310209	8T1V-GPR6-PubChem 118310209-Na
13.64	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
13.64	Single	8XQT	Cholesterol	8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
13.64	Single	8YNT	SNAP-94847	8YNT-MCH1-SNAP-94847
13.64	Single	8ZR5	Firuglipel	8ZR5-GPR119-Firuglipel-Gs/β1/γ2
13.64	Consensus	d4_on_gp	Orthosteric Ligand	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.64	Consensus	m3_off	Orthosteric Ligand	4U15-M₃-Tiotropium 4U16-M₃-N-Methyl-Scopolamine 5ZHP-M₃-PubChem 134828589
13.64	Consensus	m5_off	Orthosteric Ligand	6OL9-M₅-Tiotropium
13.33	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
13.04	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
13.04	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
13.04	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
13.04	Single	7DFP	Spiperone	7DFP-D₂-Spiperone
13.04	Single	7EPE	NAM563	7EPE-mGlu2; mGlu2-NAM563
13.04	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
13.04	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
13.04	Single	8FYE	4-F,5-MeO-PyrT	8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
13.04	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/β1/γ2
13.04	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/β1/γ2
13.04	Single	8GTM	BMK-C203	8GTM-CRF₁-BMK-C203
13.04	Single	8VHF	MBX-2982	8VHF-GPR119-MBX-2982-Gs/β1/γ2
13.04	Single	8XJN	Cloprosetnol	8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04	Consensus	gi_amine	Orthosteric Ligand	gi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
13.04	Consensus	gi_muscarinic	Orthosteric Ligand	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2
12.90	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/β1/γ2
12.82	Single	8F0J	Pramlintide Analogue San45	8F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
12.50	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
12.50	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/β1/γ2
12.50	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
12.50	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/β1/γ1
12.50	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
12.50	Single	7SK7	CCX662	7SK7-ACKR3-CXCL12-CCX662
12.50	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/β1/γ2
12.50	Single	8DPH	Lorcaserin	8DPH-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
12.50	Single	8E9Y	Clozapine-N-oxide	8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50	Single	8F0K	Pramlintide Analogue San385	8F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
12.50	Single	8F2B	Pramlintide Analogue San45	8F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
12.50	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
12.50	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/β1/γ2
12.50	Single	8GEI	Constrained Epinephrine	8GEI-β₂-Constrained Epinephrine-Gs/β1/γ2
12.50	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Single	8IWM	2-Phenylethylamine	8IWM-TA9-2-Phenylethylamine
12.50	Single	8WC5	Tetramethylammonium Ion	8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
12.50	Single	8XJK	Cloprosetnol	8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Single	8XJO	U46619	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Consensus	prostanoid_on	Orthosteric Ligand	tp_on fp-alpha_on
12.50	Consensus	prostanoid_on_gp	Orthosteric Ligand	tp_on_gp fp-alpha_on_gp
12.50	Consensus	tp_on	Orthosteric Ligand	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Consensus	tp_on_gp	Orthosteric Ligand	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
12.00	Single	3NY9	ICI118-551	3NY9-β₂-ICI118-551
12.00	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
12.00	Single	5EE7	MK0893	5EE7-Glucagon-MK0893
12.00	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
12.00	Single	7SK9	CCX662	7SK9-ACKR3-CCX662
12.00	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
12.00	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
11.76	Single	7EJK	Oxymetazoline	7EJK-α_2a-Oxymetazoline-Go/β1/γ2
11.76	Single	7F23	Dopamine	7F23-D₁-Dopamine-GDP-Gs/β1/γ2
11.76	Single	8DPI	Lorcaserin	8DPI-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/β1/γ2
11.76	Single	8FLU	Long-Acting PTH	8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
11.76	Single	8GGF	Constrained Epinephrine	8GGF-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76	Single	8ITF	DMCHA	8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
11.76	Single	8J6Q	Beta-Hydroxybutyrate	8J6Q-HCA₂-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
11.76	Single	8JXT	Histamine	8JXT-H₄-Histamine-PO4-Gi1/β1/γ2
11.76	Single	8WC6	2-Phenylethylamine	8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
11.76	Single	8WC9	ZH8651	8WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76	Single	8XQP	Aristolochic acid A	8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
11.54	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/β1/γ2
11.54	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/β1/γ2
11.54	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
11.54	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
11.54	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
11.54	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
11.54	Single	8WDT	photoNECA	8WDT-A_2A-photoNECA
11.43	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/β1/γ2
11.11	Single	3AYM	All-trans-Retinal	3AYM-Rhodopsin-All-trans-Retinal
11.11	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
11.11	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
11.11	Single	6QNO	All-trans-Retinal	6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
11.11	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.11	Single	7DFL	Histamine	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
11.11	Single	7E2Y	Serotonin	7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2
11.11	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/β1/γ2
11.11	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
11.11	Single	7V68	Iperoxo	7V68-M₄-Iperoxo-PubChem 57664406-Gi1/β1/γ2
11.11	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/β1/γ2
11.11	Single	7YFC	Histamine	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	8DPF	Lorcaserin	8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11	Single	8GGY	Constrained Epinephrine	8GGY-β₂-Constrained Epinephrine
11.11	Single	8H2G	Niacin	8H2G-HCA₂-Niacin-Gi1/β1/γ2
11.11	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
11.11	Single	8IHI	Acifran	8IHI-HCA₂-Acifran-Gi1/β1/γ2
11.11	Single	8JIL	Niacin	8JIL-HCA₂-Niacin-Gi1/β1/γ2
11.11	Single	8JLO	Ulotaront	8JLO-TA1-Ulotaront-Gs/β1/γ2
11.11	Single	8K5B	Niacin	8K5B-HCA₂-Niacin
11.11	Single	8UO3	Constrained Epinephrine	8UO3-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
11.11	Single	8W89	PEA	8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
11.11	Single	8YN4	Histamine	8YN4-H₂-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11	Single	9IQT	Niacin	9IQT-HCA₂-Niacin-Gi1/β1/γ2
11.11	Consensus	h1_on	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.81	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
10.71	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
10.71	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
10.71	Single	9B54	A1AIW	9B54-CB₁-A1AIW-Gi1/β1/γ2
10.53	Single	2Z73	11-cis-Retinal	2Z73-Rhodopsin-11-cis-Retinal
10.53	Single	3AYN	9-cis-Retinal	3AYN-Rhodopsin-9-cis-Retinal
10.53	Single	4K5Y	CP-376395	4K5Y-CRF₁-CP-376395
10.53	Single	4S0V	Suvorexant	4S0V-OX₂-Suvorexant
10.53	Single	6B73	MP1104	6B73-κ-MP1104
10.53	Single	6KUY	PubChem 145704643	6KUY-α_2a-PubChem 145704643
10.53	Single	6TOD	EMPA	6TOD-OX₁-EMPA-Na
10.53	Single	6TPJ	Suvorexant	6TPJ-OX₂-Suvorexant
10.53	Single	7DHR	Isoprenaline	7DHR-β₂-Isoprenaline-Gs/β1/γ2
10.53	Single	7LD4	Adenosine	7LD4-A₁-Adenosine-Gi2/β1/γ2
10.53	Single	7LJD	Dopamine	7LJD-D₁-Dopamine-Mevidalen-Gs/β1/γ1
10.53	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
10.53	Single	7YM8	Oxymetazoline	7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
10.53	Single	7YMH	Norepinephrine	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
10.53	Single	8EFO	PZM21	8EFO-μ-PZM21-Gi1/β1/γ2
10.53	Single	8FYX	Buspirone	8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1
10.53	Single	8GGA	Constrained Epinephrine	8GGA-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53	Single	8GGC	Constrained Epinephrine	8GGC-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53	Single	8GGR	Constrained Epinephrine	8GGR-β₂-Constrained Epinephrine
10.53	Single	8GGW	Constrained Epinephrine	8GGW-β₂-Constrained Epinephrine
10.53	Single	8GGZ	Constrained Epinephrine	8GGZ-β₂-Constrained Epinephrine
10.53	Single	8GH0	Constrained Epinephrine	8GH0-β₂-Constrained Epinephrine
10.53	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/β1/γ2
10.53	Single	8IJA	Niacin	8IJA-HCA₂-Niacin-Gi1/β1/γ2
10.53	Single	8IJB	Acipimox	8IJB-HCA₂-Acipimox-Gi1/β1/γ2
10.53	Single	8J6L	Niacin	8J6L-HCA₂-Niacin-Gi1/β1/γ2
10.53	Single	8TZQ	L-Dopamine	8TZQ-D₂-L-Dopamine-Go/β1/γ2
10.53	Single	8UNX	Constrained Epinephrine	8UNX-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53	Single	8UTD	MK1903	8UTD-HCA₂-MK1903-Gi1/β1/γ2
10.53	Single	8WC3	SEP-363856	8WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
10.53	Single	8WC4	ZH8651	8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
10.53	Single	8WCA	2-Phenylethylamine	8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
10.53	Single	8XQT	Cholesterol	8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
10.53	Single	9MQJ	Isoquinuclidine	9MQJ-μ-Isoquinuclidine
10.53	Consensus	5ht1e_on	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
10.53	Consensus	a1_on	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
10.53	Consensus	a1_on_gp	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
10.53	Consensus	alpha2_off	Orthosteric Ligand	alpha2c_off
10.53	Consensus	gq_histamine	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.53	Consensus	h1_on_gp	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.34	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
10.34	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
10.34	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
10.34	Single	8WST	Pro-MCH	8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.26	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/β1/γ2
10.00	Single	4DKL	Beta-Funaltrexamine	4DKL-μ-β-Funaltrexamine
10.00	Single	4LDO	L-Epinephrine	4LDO-β₂-L-Epinephrine
10.00	Single	4N6H	Naltrindole	4N6H-δ-Naltrindole-Na
10.00	Single	4ZJC	SB-674042	4ZJC-OX₁-SB-674042
10.00	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
10.00	Single	6K41	Dexmedetomidine	6K41-α_2b-Dexmedetomidine-Go/β1/γ2
10.00	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
10.00	Single	6PS0	S-Carazolol	6PS0-β₂-S-Carazolol
10.00	Single	6PS4	ICI118-551	6PS4-β₂-ICI118-551
10.00	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
10.00	Single	6TOS	GSK1059865	6TOS-OX₁-GSK1059865-Na
10.00	Single	6TP3	Nemorexant	6TP3-OX₁-Nemorexant
10.00	Single	6TPG	EMPA	6TPG-OX₂-EMPA
10.00	Single	6VI4	JDTic	6VI4-κ-JDTic
10.00	Single	6WH4	Methiothepin	6WH4-5-HT_2A-Methiothepin
10.00	Single	6WJC	Atropine	6WJC-M₁-Atropine-Muscarinic toxin 7
10.00	Single	6ZFZ	77-LH-28-1	6ZFZ-M₁-77-LH-28-1
10.00	Single	6ZG9	GSK1034702	6ZG9-M₁-GSK1034702
10.00	Single	7BB6	AVP	7BB6-V₂-AVP-Gs/β1/γ2
10.00	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/β1/γ2
10.00	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/β1/γ2
10.00	Single	7CMU	Pramipexole	7CMU-D₃-Pramipexole-Gi1/β1/γ2
10.00	Single	7DHI	Salbutamol	7DHI-β₂-Salbutamol-Gs/β1/γ2
10.00	Single	7E33	BRL-54443	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2
10.00	Single	7EJA	Dexmedetomidine	7EJA-α_2a-Dexmedetomidine-Go/β1/γ2
10.00	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/β1/γ2
10.00	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/β1/γ2
10.00	Single	7F24	Dopamine	7F24-D₁-Dopamine-GDP-Gs/β1/γ2
10.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.00	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-α-factor mating pheromone
10.00	Single	7RAN	PubChem 164575847	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
10.00	Single	7UM7	Methylergometrine	7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
10.00	Single	7VUG	JNJ-63533054	7VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
10.00	Single	8GE1	Constrained Epinephrine	8GE1-β₂-Constrained Epinephrine-Gs/β1/γ2
10.00	Single	8GE4	Constrained Epinephrine	8GE4-β₂-Constrained Epinephrine-Gs/β1/γ2
10.00	Single	8GE6	Constrained Epinephrine	8GE6-β₂-Constrained Epinephrine-Gs/β1/γ2
10.00	Single	8GE7	Constrained Epinephrine	8GE7-β₂-Constrained Epinephrine-Gs/β1/γ2
10.00	Single	8GE8	Constrained Epinephrine	8GE8-β₂-Constrained Epinephrine-Gs/β1/γ2
10.00	Single	8GEA	Constrained Epinephrine	8GEA-β₂-Constrained Epinephrine-Gs/β1/γ2
10.00	Single	8GED	Constrained Epinephrine	8GED-β₂-Constrained Epinephrine-Gs/β1/γ2
10.00	Single	8GEF	Constrained Epinephrine	8GEF-β₂-Constrained Epinephrine-Gs/β1/γ2
10.00	Single	8GG5	Constrained Epinephrine	8GG5-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00	Single	8GG8	Constrained Epinephrine	8GG8-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00	Single	8GGQ	Constrained Epinephrine	8GGQ-β₂-Constrained Epinephrine
10.00	Single	8GGS	Constrained Epinephrine	8GGS-β₂-Constrained Epinephrine
10.00	Single	8GGT	Constrained Epinephrine	8GGT-β₂-Constrained Epinephrine
10.00	Single	8GGV	Constrained Epinephrine	8GGV-β₂-Constrained Epinephrine
10.00	Single	8GGX	Constrained Epinephrine	8GGX-β₂-Constrained Epinephrine
10.00	Single	8IHK	Acifran	8IHK-HCA₃-Acifran
10.00	Single	8IY9	Niacin	8IY9-HCA₂-Niacin-Go/β1/γ2
10.00	Single	8JEI	3-nitro-4-(propylamino)benzoic acid	8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
10.00	Single	8JER	Acipimox	8JER-HCA₂-Acipimox-Go/β1/γ2
10.00	Single	8JIM	MMF	8JIM-HCA₂-MMF-Gi1/β1/γ2
10.00	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
10.00	Single	8JLN	T1AM	8JLN-TA1-T1AM-Gs/β1/γ2
10.00	Single	8K5C	Acipimox	8K5C-HCA₂-Acipimox
10.00	Single	8THK	A61603	8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00	Single	8THL	Epinephrine	8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00	Single	8U02	L-Dopamine	8U02-D₂-L-Dopamine-Go/β1/γ2
10.00	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/β1/γ2
10.00	Single	8UNM	Constrained Epinephrine	8UNM-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00	Single	8UNW	Constrained Epinephrine	8UNW-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00	Single	8UO0	Constrained Epinephrine	8UO0-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00	Single	8W88	SEP-363856	8W88-TA1-SEP-363856-Gs/β1/γ2
10.00	Single	8W8B	SEP-363856	8W8B-5-HT_1A-SEP-363856-Gi1/β1/γ2
10.00	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
10.00	Single	8X7A	Treprostinil	8X7A-I2-Treprostinil-Gs/β1/γ2
10.00	Single	8Y45	ADL5859	8Y45-δ-ADL5859-Gi2/β1/γ2
10.00	Single	8Y53	MK5046	8Y53-BB₃-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Single	8YH2	Adenosine	8YH2-A_3A-Adenosine-Gi1/β1/γ2
10.00	Single	8YN3	Histamine	8YN3-H₂-Histamine-Gs/β1/γ2
10.00	Single	9BJK	Naloxone	9BJK-μ-Naloxone-NAM
10.00	Single	9CBL	Epinephrine	9CBL-α_2a-Epinephrine-Gi1/β1/γ2
10.00	Single	9MQI	Isoquinuclidine	9MQI-μ-Isoquinuclidine
10.00	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on a3_on
10.00	Consensus	alpha1_on	Orthosteric Ligand	alpha1a_on
10.00	Consensus	alpha1_on_gp	Orthosteric Ligand	alpha1a_on_gp
10.00	Consensus	alpha1a_on	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2
10.00	Consensus	alpha1a_on_gp	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2
10.00	Consensus	d3_on	Orthosteric Ligand	7CMV-D₃-PD128907-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2
10.00	Consensus	d3_on_gp	Orthosteric Ligand	7CMV-D₃-PD128907-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2
10.00	Consensus	gi_adenosine	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2 8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
10.00	Consensus	hca_on	Orthosteric Ligand	hca2_on
10.00	Consensus	nop_off	Orthosteric Ligand	4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
9.68	Single	6FJ3	PTH	6FJ3-PTH1-PTH
9.68	Single	6NBF	Long-Acting PTH Analog	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
9.68	Single	6NBI	Long-Acting PTH Analog	6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
9.68	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-α-factor mating pheromone
9.68	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
9.52	Single	2Y04	Salbutamol	2Y04-β₁-Salbutamol
9.52	Single	3NY8	ICI118-551	3NY8-β₂-ICI118-551
9.52	Single	3NYA	S-Alprenolol	3NYA-β₂-S-Alprenolol
9.52	Single	4EA3	PubChem 10296561	4EA3-NOP-PubChem 10296561
9.52	Single	4EJ4	Naltrindole	4EJ4-δ-Naltrindole
9.52	Single	4GBR	S-Carazolol	4GBR-β₂-S-Carazolol
9.52	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
9.52	Single	4MQS	Iperoxo	4MQS-M₂-Iperoxo
9.52	Single	4QKX	35V	4QKX-β₂-35V
9.52	Single	4U14	Tiotropium	4U14-M₃-Tiotropium
9.52	Single	4X1H	Nonyl-Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
9.52	Single	4Z9G	CP-376395	4Z9G-CRF₁-CP-376395
9.52	Single	5DHG	C-35	5DHG-NOP-C-35
9.52	Single	5DHH	SB-612111	5DHH-NOP-SB-612111
9.52	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
9.52	Single	6DRZ	Methysergide	6DRZ-5-HT_2B-Methysergide
9.52	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
9.52	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
9.52	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
9.52	Single	6H7M	Salbutamol	6H7M-β₁-Salbutamol
9.52	Single	6IIV	Daltroban	6IIV-TP-Daltroban
9.52	Single	6K42	Dexmedetomidine	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
9.52	Single	6PS1	Timolol	6PS1-β₂-Timolol
9.52	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
9.52	Single	7BTS	L-Epinephrine	7BTS-β₁-L-Epinephrine
9.52	Single	7BU6	L-Norepinephrine	7BU6-β₁-L-Norepinephrine
9.52	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/β1/γ2
9.52	Single	7E32	Serotonin	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
9.52	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/β1/γ2
9.52	Single	7LJC	SKF-81297	7LJC-D₁-SKF-81297-Mevidalen-Gs/β1/γ2
9.52	Single	7S0G	Isoprenaline	7S0G-β₁-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
9.52	Single	7SCG	FH210	7SCG-μ-FH210-Gi1/β1/γ2
9.52	Single	7T2G	Mitragynine Pseudoindoxyl	7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
9.52	Single	7TRP	Iperoxo	7TRP-M₄-Iperoxo-LY2033298-Gi1/β1/γ2
9.52	Single	7UL4	Alvimopan	7UL4-μ-Alvimopan
9.52	Single	7VKT	LTB4	7VKT-BLT₁-LTB4-Gi1/β1/γ2
9.52	Single	7WC8	Lumateperone	7WC8-5-HT_2A-Lumateperone
9.52	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/β1/γ2
9.52	Single	7YAC	Paltusotine	7YAC-SST2-Paltusotine-Gi1/β1/γ2
9.52	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
9.52	Single	8FY8	5-MeO-DMT	8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1
9.52	Single	8GE3	Constrained Epinephrine	8GE3-β₂-Constrained Epinephrine-Gs/β1/γ2
9.52	Single	8GE9	Constrained Epinephrine	8GE9-β₂-Constrained Epinephrine-Gs/β1/γ2
9.52	Single	8GEC	Constrained Epinephrine	8GEC-β₂-Constrained Epinephrine-Gs/β1/γ2
9.52	Single	8GEE	Constrained Epinephrine	8GEE-β₂-Constrained Epinephrine-Gs/β1/γ2
9.52	Single	8GEH	Constrained Epinephrine	8GEH-β₂-Constrained Epinephrine-Gs/β1/γ2
9.52	Single	8GFV	Constrained Epinephrine	8GFV-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8GFW	Constrained Epinephrine	8GFW-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8GFX	Constrained Epinephrine	8GFX-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8GFZ	Constrained Epinephrine	8GFZ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8GG0	Constrained Epinephrine	8GG0-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8GG1	Constrained Epinephrine	8GG1-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8GG3	Constrained Epinephrine	8GG3-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8GG4	Constrained Epinephrine	8GG4-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8GG6	Constrained Epinephrine	8GG6-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8GG9	Constrained Epinephrine	8GG9-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8GGI	Constrained Epinephrine	8GGI-β₂-Constrained Epinephrine
9.52	Single	8GGJ	Constrained Epinephrine	8GGJ-β₂-Constrained Epinephrine
9.52	Single	8GGK	Constrained Epinephrine	8GGK-β₂-Constrained Epinephrine
9.52	Single	8GGN	Constrained Epinephrine	8GGN-β₂-Constrained Epinephrine
9.52	Single	8GGO	Constrained Epinephrine	8GGO-β₂-Constrained Epinephrine
9.52	Single	8GGU	Constrained Epinephrine	8GGU-β₂-Constrained Epinephrine
9.52	Single	8GTI	BMK-C205	8GTI-CRF₁-BMK-C205
9.52	Single	8I7V	Acipimox	8I7V-HCA₂-Acipimox-Gi1/β1/γ2
9.52	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/β1/γ2
9.52	Single	8IRT	Rotigotine	8IRT-D₃-Rotigotine-Gi1/β1/γ2
9.52	Single	8J6P	Niacin	8J6P-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
9.52	Single	8JHN	MMF	8JHN-HCA₂-MMF-Go/β1/γ2
9.52	Single	8JII	Niacin	8JII-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
9.52	Single	8JJO	Alprenolol	8JJO-β₂-Alprenolol
9.52	Single	8JLJ	T1AM	8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
9.52	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
9.52	Single	8JXR	LSD	8JXR-D₁-LSD
9.52	Single	8K5D	GSK256073	8K5D-HCA₂-GSK256073
9.52	Single	8PJK	ST171	8PJK-5-HT_1A-ST171-t7m-Gi1/β1/γ1
9.52	Single	8UGY	Mianserin	8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1
9.52	Single	8UNQ	Constrained Epinephrine	8UNQ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8UNR	Constrained Epinephrine	8UNR-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8UNU	Constrained Epinephrine	8UNU-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8UNV	Constrained Epinephrine	8UNV-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8UNY	Constrained Epinephrine	8UNY-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8UNZ	Constrained Epinephrine	8UNZ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8UO2	Constrained Epinephrine	8UO2-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8UWL	Lisuride	8UWL-5-HT_2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
9.52	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
9.52	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
9.52	Single	8WC7	ZH8667	8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
9.52	Single	8X17	Namodenoson	8X17-A_3A-Namodenoson-Gi1/β1/γ2
9.52	Single	8X63	Mepyramine	8X63-H₁-Mepyramine
9.52	Single	8XJL	PGF2-alpha	8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
9.52	Single	8XVK	Ambrisentan	8XVK-ET_A-Ambrisentan
9.52	Single	8ZQE	GPR15L(C11)	8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
9.52	Single	8ZSS	RO5263397	8ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
9.52	Single	9CBM	Dexmedetomidine	9CBM-α_2a-Dexmedetomidine-Gi1/β1/γ2
9.52	Single	9D61	JDTic	9D61-κ-JDTic-Gi1/β1/γ2
9.52	Consensus	5ht1d_on	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
9.52	Consensus	5ht1d_on_gp	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
9.52	Consensus	5ht2b_off	Orthosteric Ligand	6DRZ-5-HT_2B-Methysergide
9.52	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
9.52	Consensus	5ht6_on_gp	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
9.52	Consensus	a3_on	Orthosteric Ligand	a3a_on
9.52	Consensus	adenosine_on_gp	Orthosteric Ligand	a1_on_gp a2_on_gp a3_on_gp
9.52	Consensus	adrenergic_on	Orthosteric Ligand	alpha_on beta_on
9.52	Consensus	alicarboxylic_on_gp	Orthosteric Ligand	succinate_on_gp hca_on_gp
9.52	Consensus	alpha2_on	Orthosteric Ligand	alpha2b_on
9.52	Consensus	alpha2_on_gp	Orthosteric Ligand	alpha2b_on_gp
9.52	Consensus	alpha2b_on	Orthosteric Ligand	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
9.52	Consensus	alpha2b_on_gp	Orthosteric Ligand	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
9.52	Consensus	alpha_on	Orthosteric Ligand	alpha1_on alpha2_on
9.52	Consensus	blt1_on	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
9.52	Consensus	blt1_on_gp	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
9.52	Consensus	blt_on	Orthosteric Ligand	blt1_on
9.52	Consensus	blt_on_gp	Orthosteric Ligand	blt1_on_gp
9.52	Consensus	d5_on	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
9.52	Consensus	dop_off	Orthosteric Ligand	4EJ4-δ-Naltrindole
9.52	Consensus	dopamine_off	Orthosteric Ligand	d2_off d3_off
9.52	Consensus	dopamine_on	Orthosteric Ligand	d2_on d1_on d3_on d4_on d5_on
9.52	Consensus	dopamine_on_gp	Orthosteric Ligand	d2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
9.52	Consensus	gi_alicarboxylic	Orthosteric Ligand	gi_hca gi_succinate
9.52	Consensus	gi_hca	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
9.52	Consensus	gi_leukotriene	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
9.52	Consensus	gq_amine	Orthosteric Ligand	gq_muscarinic gq_histamine
9.52	Consensus	gs_trace-amine	Orthosteric Ligand	8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
9.52	Consensus	hca2_on	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2
9.52	Consensus	hca2_on_gp	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
9.52	Consensus	hca_on_gp	Orthosteric Ligand	hca2_on_gp
9.52	Consensus	histamine_off	Orthosteric Ligand	h1_off
9.52	Consensus	leukotriene_on	Orthosteric Ligand	blt_on
9.52	Consensus	leukotriene_on_gp	Orthosteric Ligand	blt_on_gp
9.38	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
9.38	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
9.38	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/β1/γ2
9.38	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-α-factor mating pheromone
9.38	Single	8FEG	(DNCP)-Beta-Naloxamine	8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
9.09	Single	2RH1	S-Carazolol	2RH1-β₂-S-Carazolol
9.09	Single	2Y03	Isoprenaline	2Y03-β₁-Isoprenaline
9.09	Single	2YCW	S-Carazolol	2YCW-β₁-S-Carazolol
9.09	Single	5C1M	BU72	5C1M-μ-BU72
9.09	Single	5D6L	S-Carazolol	5D6L-β₂-S-Carazolol
9.09	Single	5TVN	LSD	5TVN-5-HT_2B-LSD
9.09	Single	5WIU	Nemonapride	5WIU-D₄-Nemonapride
9.09	Single	5WIV	Nemonapride	5WIV-D₄-Nemonapride-Na
9.09	Single	5WQC	EMPA	5WQC-OX₂-EMPA
9.09	Single	5X7D	S-Carazolol	5X7D-β₂-S-Carazolol-PubChem 129318963
9.09	Single	6KUW	PubChem 57213234	6KUW-α_2c-PubChem 57213234
9.09	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
9.09	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
9.09	Single	6NBH	Long-Acting PTH Analog	6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
9.09	Single	6PS3	S-Carvedilol	6PS3-β₂-S-Carvedilol
9.09	Single	7BVQ	S-Carazolol	7BVQ-β₁-S-Carazolol
9.09	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
9.09	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-α-factor mating pheromone
9.09	Single	7S0F	Isoprenaline	7S0F-β₁-Isoprenaline-Gi1/β1/γ2
9.09	Single	7SBF	PZM21	7SBF-μ-PZM21-Gi1/β1/γ2
9.09	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
9.09	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
9.09	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
9.09	Single	7VOE	Aripiprazole	7VOE-5-HT_2A-Aripiprazole
9.09	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
9.09	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
9.09	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/β1/γ2
9.09	Single	7WC6	LSD	7WC6-5-HT_2A-LSD
9.09	Single	7WIG	L-054,264	7WIG-SST2-L-054,264-Gi1/β1/γ2
9.09	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09	Single	7XK9	Constrained Isoproterenol	7XK9-β₂-Constrained Isoproterenol-Na
9.09	Single	7XKA	Constrained Epinephrine	7XKA-β₂-Constrained Epinephrine
9.09	Single	8DZQ	momSalB	8DZQ-κ-momSalB-Go/β1/γ2
9.09	Single	8DZR	GR89,696	8DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
9.09	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/β1/γ2
9.09	Single	8GDZ	Constrained Epinephrine	8GDZ-β₂-Constrained Epinephrine-Gs/β1/γ2
9.09	Single	8GEB	Constrained Epinephrine	8GEB-β₂-Constrained Epinephrine-Gs/β1/γ2
9.09	Single	8GEG	Constrained Epinephrine	8GEG-β₂-Constrained Epinephrine-Gs/β1/γ2
9.09	Single	8GFY	Constrained Epinephrine	8GFY-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09	Single	8GG2	Constrained Epinephrine	8GG2-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09	Single	8GGB	Constrained Epinephrine	8GGB-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09	Single	8GTG	BMK-I152	8GTG-CRF₁-BMK-I152
9.09	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
9.09	Single	8HNL	PS372424	8HNL-CXCR3-PS372424-Gi1/β1/γ2
9.09	Single	8I7W	GSK256073	8I7W-HCA₂-GSK256073-Gi1/β1/γ2
9.09	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/β1/γ2
9.09	Single	8TF5	Oleic acid	8TF5-GPR6-Oleic acid
9.09	Single	8UNN	Constrained Epinephrine	8UNN-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09	Single	8UNP	Constrained Epinephrine	8UNP-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09	Single	8UUJ	FCH-2296413	8UUJ-HCA₂-FCH-2296413-Gi1/β1/γ2
9.09	Single	8VVE	norBNI	8VVE-κ-norBNI-Gi1/β1/γ2
9.09	Single	8XYK	VUF10661	8XYK-CXCR3-VUF10661-Go1/β1/γ2
9.09	Single	8YH0	NECA	8YH0-A_3A-NECA-Gi1/β1/γ2
9.09	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
9.09	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
9.09	Single	9F34	FOB02-04A	9F34-D₃-FOB02-04A-Go1/β1/γ2
9.09	Single	9MQK	Isoquinuclidine	9MQK-κ-Isoquinuclidine
9.09	Consensus	5ht1_on	Orthosteric Ligand	5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
9.09	Consensus	5ht1_on_gp	Orthosteric Ligand	5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
9.09	Consensus	5ht1e_on_gp	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
9.09	Consensus	5ht2_off	Orthosteric Ligand	5ht2a_off 5ht2b_off 5ht2c_off
9.09	Consensus	5ht5_on_gp	Orthosteric Ligand	5ht5a_on_gp
9.09	Consensus	5ht5a_on_gp	Orthosteric Ligand	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
9.09	Consensus	a3_on_gp	Orthosteric Ligand	a3a_on_gp
9.09	Consensus	a3a_on	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
9.09	Consensus	a3a_on_gp	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
9.09	Consensus	adrenergic_off	Orthosteric Ligand	alpha_off beta_off
9.09	Consensus	adrenergic_on_gp	Orthosteric Ligand	alpha_on_gp beta_on_gp
9.09	Consensus	alpha2c_off	Orthosteric Ligand	6KUW-α_2c-PubChem 57213234
9.09	Consensus	alpha_off	Orthosteric Ligand	alpha1_off alpha2_off
9.09	Consensus	alpha_on_gp	Orthosteric Ligand	alpha1_on_gp alpha2_on_gp
9.09	Consensus	amine_off	Orthosteric Ligand	5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
9.09	Consensus	amine_offon	Orthosteric Ligand	amine_off amine_on
9.09	Consensus	amine_offon_gp	Orthosteric Ligand	amine_on_gp amine_off
9.09	Consensus	amine_on	Orthosteric Ligand	5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
9.09	Consensus	beta2_off	Orthosteric Ligand	2RH1-β₂-S-Carazolol 6PS3-β₂-S-Carvedilol 6PS5-β₂-S-Propranolol 3D4S-β₂-Timolol 3NY8-β₂-ICI118-551 3NY9-β₂-ICI118-551 6PRZ-β₂-S-Alprenolol
9.09	Consensus	beta_off	Orthosteric Ligand	beta1_off beta2_off
9.09	Consensus	d2_on	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2
9.09	Consensus	d4_on	Orthosteric Ligand	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
9.09	Consensus	gi_adrenergic	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
9.09	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
9.09	Consensus	h1_off	Orthosteric Ligand	8X63-H₁-Mepyramine 3RZE-H₁-Cidoxepin 8X5Y-H₁-Astemizole
9.09	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09	Consensus	trace-amine_on	Orthosteric Ligand	ta1_on
8.82	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2
8.82	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
8.70	Single	4DJH	JDTic	4DJH-κ-JDTic
8.70	Single	4LDL	Hydroxybenzylisoproterenol	4LDL-β₂-Hydroxybenzylisoproterenol
8.70	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
8.70	Single	5D5A	S-Carazolol	5D5A-β₂-S-Carazolol
8.70	Single	5D5B	S-Carazolol	5D5B-β₂-S-Carazolol
8.70	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
8.70	Single	6H7J	Isoprenaline	6H7J-β₁-Isoprenaline
8.70	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
8.70	Single	6KO5	PubChem 57400002	6KO5-Ghrelin-PubChem 57400002
8.70	Single	6N48	BI167107	6N48-β₂-BI167107-PubChem 138454256
8.70	Single	6NI3	BI167107	6NI3-β₂-BI167107-Gs/β1/γ2
8.70	Single	6TQ7	SB-334867	6TQ7-OX₁-SB-334867
8.70	Single	6WGT	LSD	6WGT-5-HT_2A-LSD
8.70	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/β1/γ2
8.70	Single	7E2Z	Aripiprazole	7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2
8.70	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
8.70	Single	7EW7	SEW2871	7EW7-S1P₁-SEW2871-Gi1/β1/γ2
8.70	Single	7JJO	Isoprenaline	7JJO-β₁-Isoprenaline-Gs/β1/γ2
8.70	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/β1/γ2
8.70	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
8.70	Single	7W6P	N-pyridin-4-ylisoquinolin-4-amine	7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
8.70	Single	7W7E	PubChem 164946676	7W7E-α_2a-PubChem 164946676-Go/β1/γ2
8.70	Single	7WV9	CP55940	7WV9-CB₁-CP55940-ZCZ011-Gi2/β1/γ2
8.70	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/β1/γ2
8.70	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/β1/γ2
8.70	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/β1/γ2
8.70	Single	8E0G	BU72	8E0G-μ-BU72
8.70	Single	8EFL	SR17018	8EFL-μ-SR17018-Gi1/β1/γ2
8.70	Single	8GDB	PGE2	8GDB-EP₄-PGE2-Gs/β1/γ2
8.70	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
8.70	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/β1/γ2
8.70	Single	8IHH	LUF6283	8IHH-HCA₂-LUF6283-Gi1/β1/γ2
8.70	Single	8IRR	Rotigotine	8IRR-D₁-Rotigotine-Gs/β1/γ2
8.70	Single	8IRV	Rotigotine	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
8.70	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/β1/γ2
8.70	Single	8J20	AR420626	8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
8.70	Single	8JT6	(R)-IHCH-7179	8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2
8.70	Single	8UGW	PubChem 3086599	8UGW-A_2A-PubChem 3086599
8.70	Single	8VVF	JDTic	8VVF-κ-JDTic-Gi1/β1/γ2
8.70	Single	8X16	Piclidenoson	8X16-A_3A-Piclidenoson-Gi1/β1/γ2
8.70	Single	8XIP	Pasireotide	8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.70	Single	8XZI	CMF-019	8XZI-Apelin-CMF-019-Gi1/β1/γ2
8.70	Single	8YH6	Namodenoson	8YH6-A_3A-Namodenoson-Gi1/β1/γ2
8.70	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
8.70	Single	9F33	FOB02-04A	9F33-D₃-FOB02-04A-Go1/β1/γ2
8.70	Single	9IJD	Carazolol	9IJD-β₃-Carazolol-chim(NtGi1-Gs)/β1/γ2
8.70	Consensus	a2_on	Orthosteric Ligand	a2b_on
8.70	Consensus	a2_on_gp	Orthosteric Ligand	a2b_on_gp
8.70	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
8.70	Consensus	a2b_on_gp	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
8.70	Consensus	amine_on_gp	Orthosteric Ligand	5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
8.70	Consensus	beta1_off	Orthosteric Ligand	2VT4-β₁-Cyanopindolol 2YCW-β₁-S-Carazolol 2YCZ-β₁-Iodocyanopindolol 5A8E-β₁-7-Methylcyanopindolol-Na 3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
8.70	Consensus	beta2_on	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2
8.70	Consensus	beta2_on_gp	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2
8.70	Consensus	d1_on_gp	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
8.70	Consensus	d5_on_gp	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
8.70	Consensus	gi_5ht	Orthosteric Ligand	8FYT-5-HT_1A-LSD-Gi1/β1/γ1 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT_1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2 7E32-5-HT_1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT₄-Serotonin-Gi1/β1/γ2 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2
8.70	Consensus	gi_dopamine	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 7CMV-D₃-PD128907-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2
8.70	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
8.70	Consensus	gs_adrenergic	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2 7JJO-β₁-Isoprenaline-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2 8DCR-β₁-Dobutamine-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7DH5-β₃-Mirabegron-Gs/β1/γ2
8.70	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2
8.70	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
8.70	Consensus	kop_off	Orthosteric Ligand	4DJH-κ-JDTic
8.70	Consensus	protein_off	Orthosteric Ligand	chemokine_off grh_off
8.70	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
8.70	Consensus	s1p5_on_gp	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
8.70	Consensus	ta1_on_gp	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.70	Consensus	trace-amine_on_gp	Orthosteric Ligand	ta1_on_gp
8.57	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/β1/γ1
8.57	Single	8F2A	Pramlintide Analogue San385	8F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
8.33	Single	3D4S	Timolol	3D4S-β₂-Timolol
8.33	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
8.33	Single	4LDE	BI167107	4LDE-β₂-BI167107
8.33	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
8.33	Single	6AK3	Dinoprostone IPGE2	6AK3-EP₃-Dinoprostone IPGE2
8.33	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
8.33	Single	6DRY	Methylergonovine	6DRY-5-HT_2B-Methylergonovine
8.33	Single	6H7N	S-Xamoterol	6H7N-β₁-S-Xamoterol
8.33	Single	6H7O	Cyanopindolol	6H7O-β₁-Cyanopindolol
8.33	Single	6IIU	Ramatroban	6IIU-TP-Ramatroban
8.33	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/β1/γ2
8.33	Single	6ZG4	HTL0009936	6ZG4-M₁-HTL0009936
8.33	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/β1/γ2
8.33	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/β1/γ2
8.33	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/β1/γ2
8.33	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
8.33	Single	7JNI	Olodanrigan	7JNI-AT₂-Olodanrigan
8.33	Single	7K15	MKD046	7K15-BLT₁-MKD046-Na
8.33	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
8.33	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/β1/γ2
8.33	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
8.33	Single	7YMJ	Tamsulosin	7YMJ-Alpha1A-Tamsulosin
8.33	Single	8FYT	LSD	8FYT-5-HT_1A-LSD-Gi1/β1/γ1
8.33	Single	8IQ6	Latanoprost	8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/β1/γ2
8.33	Single	8IYW	GSK256073	8IYW-HCA₂-GSK256073-Go/β1/γ2
8.33	Single	8JJ8	Formoterol	8JJ8-β₂-Formoterol
8.33	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/β1/γ2
8.33	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
8.33	Single	8XQN	Cholesterol	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
8.33	Single	8XYI	VUF10661	8XYI-CXCR3-VUF10661
8.33	Single	9JR2	PTH	9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33	Single	9MQL	Isoquinuclidine	9MQL-κ-Isoquinuclidine
8.33	Consensus	5ht1a_on	Orthosteric Ligand	8FYT-5-HT_1A-LSD-Gi1/β1/γ1 7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
8.33	Consensus	5ht1a_on_gp	Orthosteric Ligand	8FYT-5-HT_1A-LSD-Gi1/β1/γ1 8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
8.33	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
8.33	Consensus	5ht1f_on_gp	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
8.33	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off
8.33	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin
8.33	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
8.33	Consensus	beta3_on_gp	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
8.33	Consensus	beta_on	Orthosteric Ligand	beta1_on beta2_on beta3_on
8.33	Consensus	beta_on_gp	Orthosteric Ligand	beta1_on_gp beta2_on_gp beta3_on_gp
8.33	Consensus	cannabinoid_off	Orthosteric Ligand	cb2_off cb1_off
8.33	Consensus	d2_on_gp	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2
8.33	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
8.33	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
8.33	Consensus	m4_on_gp	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
8.33	Consensus	mop_on	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
8.33	Consensus	mop_on_gp	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
8.33	Consensus	nk1_off	Orthosteric Ligand	6HLP-NK₁-Netupitant 6HLO-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
8.33	Consensus	opioid_off	Orthosteric Ligand	mop_off nop_off dop_off kop_off
8.33	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33	Consensus	trh_on_gp	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.11	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/β1/γ2
8.00	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
8.00	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
8.00	Single	5UNG	PubChem 15780052	5UNG-AT₂-PubChem 15780052
8.00	Single	5X93	K-8794	5X93-ET_B-K-8794
8.00	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
8.00	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
8.00	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
8.00	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/β1/γ2
8.00	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2
8.00	Single	7EZC	UKA	7EZC-A_2A-UKA
8.00	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2
8.00	Single	7SK8	CCX662	7SK8-ACKR3-CXCL12-CCX662
8.00	Single	7UM4	AS2674723	7UM4-5-HT_5A-AS2674723
8.00	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/β1/γ2
8.00	Single	7XK2	MK6892	7XK2-HCA₂-MK6892-Gi1/β1/γ2
8.00	Single	8ID8	TUG-891	8ID8-FFA4-TUG-891-Gi1/β1/γ2
8.00	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/β1/γ2
8.00	Single	8XGS	Metastin	8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
8.00	Single	8XIO	L797591	8XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.00	Single	9IZF	NKP	9IZF-LPA₁-NKP-Gi1/β1/γ2
8.00	Consensus	beta1_on	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
8.00	Consensus	beta1_on_gp	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
8.00	Consensus	class-a_on	Orthosteric Ligand	sensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
8.00	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
8.00	Consensus	endothelin_off	Orthosteric Ligand	etb_off
8.00	Consensus	etb_off	Orthosteric Ligand	5X93-ET_B-K-8794 5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500
8.00	Consensus	kop_on_gp	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
8.00	Consensus	nucleotide_on_gp	Orthosteric Ligand	adenosine_on_gp p2y_on_gp
7.69	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
7.69	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
7.69	Single	7T11	Octreotide	7T11-SST2-Octreotide-Gi3/β1/γ2
7.69	Single	7XN9	L-054,522	7XN9-SST2-L-054,522
7.69	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/β1/γ2
7.69	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/β1/γ2
7.69	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
7.69	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
7.69	Single	8X3L	XWD	8X3L-CB₂-XWD-Gi1/β1/γ2
7.69	Single	8XQL	Cholesterol	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
7.69	Single	8XQO	Cholesterol	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
7.69	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
7.69	Consensus	cxcr3_on	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
7.69	Consensus	s1p_on	Orthosteric Ligand	s1p1_on s1p3_on s1p5_on
7.69	Consensus	s1p_on_gp	Orthosteric Ligand	s1p1_on_gp s1p3_on_gp s1p5_on_gp
7.69	Consensus	sst2_on	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
7.69	Consensus	sst2_on_gp	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
7.41	Single	4AMJ	S-Carvedilol	4AMJ-β₁-S-Carvedilol
7.41	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
7.41	Single	5UNF	PubChem 15780052	5UNF-AT₂-PubChem 15780052
7.41	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
7.41	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/β1/γ2
7.41	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/β1/γ2
7.41	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2
7.41	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
7.41	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/β1/γ2
7.41	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/β1/γ2
7.41	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/β1/γ2
7.41	Single	8FYL	Vilazodone	8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
7.41	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/β1/γ2
7.41	Single	8PKM	Befiradol	8PKM-5-HT_1A-Befiradol-t7m-Gi1/β1/γ1
7.41	Single	8ZCJ	Pasireotide	8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
7.41	Single	8ZSP	LSD	8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.41	Consensus	class-a_on_gp	Orthosteric Ligand	sensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
7.41	Consensus	gi_nucleotide	Orthosteric Ligand	gi_adenosine gi_p2y
7.41	Consensus	gi_opioid	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
7.41	Consensus	mop_off	Orthosteric Ligand	4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
7.41	Consensus	sst5_on	Orthosteric Ligand	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
7.14	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
7.14	Single	6DO1	Angiotensin-like peptide S1I8	6DO1-AT₁-Angiotensin-like peptide S1I8
7.14	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
7.14	Single	7DDZ	JNJ-31020028	7DDZ-Y₂-JNJ-31020028
7.14	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/β1/γ2
7.14	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
7.14	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2
7.14	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/β1/γ2
7.14	Single	8SG1	Chemerin-9	8SG1-CML1-Chemerin-9-Gi1/β1/γ2
7.14	Consensus	formylpeptide_on_gp	Orthosteric Ligand	fpr2-alx_on_gp fpr1-alx_on_gp
7.14	Consensus	gq_class-a	Orthosteric Ligand	gq_peptide gq_amine gq_nucleotide
7.14	Consensus	npy2_off	Orthosteric Ligand	7DDZ-Y₂-JNJ-31020028
7.14	Consensus	sst4_on	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
7.14	Consensus	sst4_on_gp	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
6.90	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
6.90	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
6.90	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/β1/γ2
6.90	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/β1/γ2
6.90	Single	8XGU	TAK448	8XGU-Kiss1-TAK448-Gi1/β1/γ2
6.90	Single	8XIQ	L796778	8XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
6.90	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
6.90	Consensus	gi_somatostatin	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
6.90	Consensus	somatostatin_on	Orthosteric Ligand	sst2_on sst4_on sst5_on
6.90	Consensus	somatostatin_on_gp	Orthosteric Ligand	sst2_on_gp sst4_on_gp sst5_on_gp
6.67	Single	4A4M	All-trans-Retinal	4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
6.67	Single	5EN0	All-trans-Retinal	5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
6.67	Single	6NIY	Adrenomedullin	6NIY-CT-Adrenomedullin-Gs/β1/γ2
6.67	Single	7KH0	AVP	7KH0-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
6.67	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Single	8GEJ	Constrained Epinephrine	8GEJ-β₂-Constrained Epinephrine-Gs/β1/γ2
6.67	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/β1/γ2
6.67	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/β1/γ2
6.67	Single	8X8L	Cortistatin	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
6.67	Single	8YW5	Retatrutide	8YW5-Glucagon-Retatrutide-Gs/β1/γ2
6.67	Single	9BKK	Cholecystokinin-8	9BKK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Consensus	cxcr3_on_gp	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
6.67	Consensus	fpr2-alx_on_gp	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
6.67	Consensus	gi_class-a	Orthosteric Ligand	gi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
6.67	Consensus	gi_formylpeptide	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
6.45	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/β1/γ2
6.45	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/β1/γ2
6.45	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
6.45	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
6.45	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/β1/γ2
6.45	Single	8WWK	MCH	8WWK-MCH1-MCH-Gi1/β1/γ2
6.45	Single	8WWM	MCH	8WWM-MCH1-MCH-Gi1/β1/γ2
6.45	Single	8XGO	TAK448	8XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
6.45	Consensus	cml1_on_gp	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
6.45	Consensus	opioid_on	Orthosteric Ligand	mop_on nop_on dop_on kop_on
6.45	Consensus	sst5_on_gp	Orthosteric Ligand	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
6.25	Single	3PXO	All-trans-Retinal	3PXO-Rhodopsin-All-trans-Retinal
6.25	Single	5DYS	All-trans-Retinal	5DYS-Rhodopsin-All-trans-Retinal
6.25	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/β1/γ2
6.25	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/β1/γ2
6.25	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
6.25	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/β1/γ2
6.25	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
6.25	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/β1/γ2
6.25	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
6.25	Single	8X9S	5alpha-DHT	8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
6.25	Single	9IV2	5alpha-DHT	9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
6.25	Consensus	opioid_on_gp	Orthosteric Ligand	mop_on_gp nop_on_gp dop_on_gp kop_on_gp
6.06	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/β1/γ2
6.06	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/β1/γ2
6.06	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
6.06	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/β1/γ2
6.06	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
6.06	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/β1/γ2
6.06	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
6.06	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/β1/γ2
6.06	Single	8WWL	MCH	8WWL-MCH1-MCH-Gi1/β1/γ2
6.06	Single	8ZH8	QRF-Amide	8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
6.06	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
5.88	Single	2HPY	All-trans-Retinal	2HPY-Rhodopsin-All-trans-Retinal
5.88	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/β1/γ2
5.88	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/β1/γ2
5.88	Single	6LML	Glucagon	6LML-Glucagon-Glucagon-Gi1/β1/γ1
5.88	Single	6OT0	25(S)-Epoxycholesterol	6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
5.88	Single	6OY9	All-trans-Retinal	6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.88	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/β1/γ2
5.88	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.88	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
5.88	Single	7MTB	All-trans-Retinal	7MTB-Rhodopsin-All-trans-Retinal-GRK1
5.88	Single	8WWN	MCH	8WWN-MCH1-MCH-Gi1/β1/γ2
5.88	Single	8ZPN	Cholesterol	8ZPN-CXCR4-AMD3100-Cholesterol
5.88	Single	9C2F	Ca; Ca; Tryptophan; '6218; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.88	Single	9CHU	Noradrenaline	9CHU-β₂-Noradrenaline
5.88	Consensus	bk2_on	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
5.88	Consensus	bk2_on_gp	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
5.88	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on
5.88	Consensus	bradykinin_on_gp	Orthosteric Ligand	bk2_on_gp
5.88	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
5.88	Consensus	gs_histamine	Orthosteric Ligand	8POK-H₂-Histamine-Gs/β1/γ2
5.88	Consensus	h2_on	Orthosteric Ligand	8POK-H₂-Histamine-Gs/β1/γ2
5.88	Consensus	opsins_on	Orthosteric Ligand	rhodopsin_on opsin1lw_on
5.88	Consensus	sensory_on	Orthosteric Ligand	opsins_on
5.71	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
5.71	Consensus	bb2_on_gp	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
5.71	Consensus	bombesin_on	Orthosteric Ligand	bb2_on
5.71	Consensus	bombesin_on_gp	Orthosteric Ligand	bb2_on_gp
5.71	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
5.56	Single	2J4Y	11-cis-Retinal	2J4Y-Rhodopsin-11-cis-Retinal
5.56	Single	2ZIY	11-cis-Retinal	2ZIY-Rhodopsin-11-cis-Retinal
5.56	Single	3C9M	11-cis-Retinal	3C9M-Rhodopsin-11-cis-Retinal
5.56	Single	3PQR	All-trans-Retinal	3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
5.56	Single	3UZA	GTPL9236	3UZA-A_2A-GTPL9236
5.56	Single	6FK9	PubChem 132473036	6FK9-Rhodopsin-PubChem 132473036
5.56	Single	6FUF	All-trans-Retinal	6FUF-Rhodopsin-All-trans-Retinal-Go
5.56	Single	7D77	Hydrocortisone	7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
5.56	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.56	Single	7MT8	All-trans-Retinal	7MT8-Rhodopsin-All-trans-Retinal-GRK1
5.56	Single	7MT9	All-trans-Retinal	7MT9-Rhodopsin-All-trans-Retinal-GRK1
5.56	Single	7MTA	All-trans-Retinal	7MTA-Rhodopsin-All-trans-Retinal-GRK1
5.56	Single	8F76	Propanoic acid	8F76-OR51E2-Propanoic acid-Gs/β1/γ2
5.56	Single	8GGE	Constrained Epinephrine	8GGE-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8GH1	Constrained Epinephrine	8GH1-β₂-Constrained Epinephrine
5.56	Single	8IU2	Retinal	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.56	Single	8JEF	(3S)-3-hydroxyoctanoic acid	8JEF-HCA₃-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
5.56	Single	8POK	Histamine	8POK-H₂-Histamine-Gs/β1/γ2
5.56	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.56	Single	8ZPL	Cholesterol	8ZPL-CXCR4-HF51116-Cholesterol
5.56	Single	8ZPM	Cholesterol	8ZPM-CXCR4-AMD070-Cholesterol
5.56	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.56	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.56	Single	9IV1	5alpha-DHT	9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
5.56	Consensus	5ht2_on	Orthosteric Ligand	5ht2b_on
5.56	Consensus	5ht2b_on	Orthosteric Ligand	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56	Consensus	gi_opsins	Orthosteric Ligand	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.56	Consensus	gi_sensory	Orthosteric Ligand	gi_opsins
5.56	Consensus	h2_on_gp	Orthosteric Ligand	8POK-H₂-Histamine-Gs/β1/γ2
5.56	Consensus	opsin1lw_on	Orthosteric Ligand	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.56	Consensus	opsin1lw_on_gp	Orthosteric Ligand	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.56	Consensus	opsins_on_gp	Orthosteric Ligand	rhodopsin_on_gp opsin1lw_on_gp
5.56	Consensus	rhodopsin_on	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.56	Consensus	sensory_on_gp	Orthosteric Ligand	opsins_on_gp
5.41	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
5.26	Single	1L9H	11-cis-Retinal	1L9H-Rhodopsin-11-cis-Retinal
5.26	Single	1U19	11-cis-Retinal	1U19-Rhodopsin-11-cis-Retinal
5.26	Single	2G87	All-trans-Retinal	2G87-Rhodopsin-All-trans-Retinal
5.26	Single	2I35	11-cis-Retinal	2I35-Rhodopsin-11-cis-Retinal
5.26	Single	3PBL	Eticlopride	3PBL-D₃-Eticlopride
5.26	Single	5L7I	Vismodegib	5L7I-SMO-Vismodegib
5.26	Single	5TE5	20-Methanoretinal	5TE5-Rhodopsin-20-Methanoretinal
5.26	Single	6I9K	9-cis-Retinal	6I9K-Rhodopsin-9-cis-Retinal
5.26	Single	6PGS	Geraniol	6PGS-Rhodopsin-Geraniol-Gt(CT)
5.26	Single	7D76	Beclomethasone	7D76-ADGRG3-Beclomethasone-Go/β1/γ2
5.26	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26	Single	7FEE	ZCZ011	7FEE-CB₁-CP55940-ZCZ011
5.26	Single	7SRQ	LSD	7SRQ-5-HT_2B-LSD
5.26	Single	7XKF	Beta-Hydroxyandrosterone	7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.26	Single	7XP6	Strychnine	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
5.26	Single	7XT9	Serotonin	7XT9-5-HT₄-Serotonin-Gs/β1/γ2
5.26	Single	7XTA	Serotonin	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
5.26	Single	7XTB	Serotonin	7XTB-5-HT₆-Serotonin-Gs/β1/γ2
5.26	Single	7YS6	Serotonin	7YS6-5-HT₆-Serotonin-chim(NtGi1-Gs)/β1/γ2
5.26	Single	8EF6	Morphine	8EF6-μ-Morphine-Gi1/β1/γ2
5.26	Single	8HNN	SCH546738	8HNN-CXCR3-SCH546738
5.26	Single	8J6P	Compound 9n	8J6P-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
5.26	Single	8JHY	Compound 9n	8JHY-HCA₂-Compound 9n-Gi1/β1/γ2
5.26	Single	8JII	Compound 9n	8JII-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
5.26	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.26	Single	8UO4	Constrained Epinephrine	8UO4-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
5.26	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26	Single	8X2K	Oleic monoethanolamide	8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
5.26	Single	8YH3	N-methyladenosine	8YH3-A_3A-N-methyladenosine-Gi1/β1/γ2
5.26	Single	8YKW	Succinic acid	8YKW-Succinate-Succinic acid-Gi1/β1/γ1
5.26	Single	8YN2	Histamine	8YN2-H₁-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26	Single	8ZSV	RO5263397	8ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
5.26	Single	9EPQ	11,20-Ethanoretinal	9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
5.26	Single	9IJE	Epinephrine	9IJE-β₃-Epinephrine-chim(NtGi1-Gs)/β1/γ2
5.26	Consensus	5ht4_on	Orthosteric Ligand	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
5.26	Consensus	5ht4_on_gp	Orthosteric Ligand	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
5.26	Consensus	d3_off	Orthosteric Ligand	3PBL-D₃-Eticlopride
5.00	Single	1GZM	11-cis-Retinal	1GZM-Rhodopsin-11-cis-Retinal
5.00	Single	2PED	9-cis-Retinal	2PED-Rhodopsin-9-cis-Retinal
5.00	Single	2X72	All-trans-Retinal	2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
5.00	Single	3C9L	11-cis-Retinal	3C9L-Rhodopsin-11-cis-Retinal
5.00	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
5.00	Single	5U09	Taranabant	5U09-CB₁-Taranabant
5.00	Single	5WS3	EMPA	5WS3-OX₂-EMPA
5.00	Single	6AKX	A4R	6AKX-CCR5-A4R
5.00	Single	6AKY	Maraviroc	6AKY-CCR5-Maraviroc
5.00	Single	6C1Q	NDT9513727	6C1Q-C5a₁-PMX53-NDT9513727
5.00	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
5.00	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
5.00	Single	6OBA	S-Alprenolol	6OBA-β₂-S-Alprenolol-GTPL11074
5.00	Single	6OYA	All-trans-Retinal	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.00	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
5.00	Single	7F1O	Dopamine	7F1O-D₁-Dopamine-GDP; Mg-Gs/β1/γ2
5.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00	Single	7SRR	LSD	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00	Single	7SRS	LSD	7SRS-5-HT_2B-LSD-Arrestin2
5.00	Single	7T6S	PubChem 24776341	7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
5.00	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/β1/γ2
5.00	Single	7X2F	Dopamine	7X2F-D₁-Dopamine-Mevidalen-Gs/β1/γ2
5.00	Single	7X5H	5-CT	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2
5.00	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/β1/γ2
5.00	Single	8A6C	All-trans-Retinal	8A6C-Rhodopsin-All-trans-Retinal
5.00	Single	8A6D	All-trans-Retinal	8A6D-Rhodopsin-All-trans-Retinal
5.00	Single	8A6E	All-trans-Retinal	8A6E-Rhodopsin-All-trans-Retinal
5.00	Single	8HMP	C17	8HMP-GPR52-C17-Gs/β1/γ2
5.00	Single	8JPP	Succinic acid	8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
5.00	Single	8JSO	AMPH	8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
5.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
5.00	Single	8U8F	Palmitic Acid	8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
5.00	Single	8UNS	Constrained Epinephrine	8UNS-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8UNT	Constrained Epinephrine	8UNT-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8WOG	Succinic acid	8WOG-Succinate-Succinic acid-Gi1/β1/γ2
5.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.00	Single	8XQN	Aristolochic acid A	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
5.00	Single	8XQR	Flufenamic acid	8XQR-TAS2R14-Flufenamic acid-Gt3/β1/γ1
5.00	Single	8XXV	Indomethacin	8XXV-DP₂-Indomethacin-A1D5Q-Gi1/β1/γ2
5.00	Single	8YKX	Maleic acid	8YKX-Succinate-Maleic acid-Gi1/β1/γ1
5.00	Single	8YUT	Amthamine	8YUT-H₂-Amthamine-Gs/β1/γ2
5.00	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.00	Single	9BQJ	RO76	9BQJ-μ-RO76-Gi1/β1/γ2
5.00	Single	9C2F	Ca; Ca; Tryptophan; '6218; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.00	Consensus	5ht2_on_gp	Orthosteric Ligand	5ht2b_on_gp
5.00	Consensus	5ht2b_on_gp	Orthosteric Ligand	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00	Consensus	5ht_on	Orthosteric Ligand	5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
5.00	Consensus	angiotensin_off	Orthosteric Ligand	at1_off
5.00	Consensus	gi_succinate	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
5.00	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
5.00	Consensus	gs_5ht	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2 7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2 7XT8-5-HT₄-Serotonin-Gs/β1/γ2
5.00	Consensus	orexin_off	Orthosteric Ligand	ox2_off ox1_off
5.00	Consensus	ox1_off	Orthosteric Ligand	6TP6-OX₁-Filorexant 6TP4-OX₁-ACT-462206 6V9S-OX₁-GTPL11403 6TOT-OX₁-Lemborexant 6TP3-OX₁-Nemorexant 6TQ6-OX₁-PubChem 145714283 6TQ9-OX₁-SB-408124 4ZJC-OX₁-SB-674042 4ZJ8-OX₁-Suvorexant 6TOD-OX₁-EMPA-Na 6TOS-OX₁-GSK1059865-Na 6TQ4-OX₁-PubChem 16046844-Na
5.00	Consensus	ox2_off	Orthosteric Ligand	5WQC-OX₂-EMPA 6TPN-OX₂-HTL6641 7XRR-OX₂-Lemborexant 6TPJ-OX₂-Suvorexant
5.00	Consensus	rhodopsin_off	Orthosteric Ligand	1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
5.00	Consensus	rhodopsin_on_gp	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.00	Consensus	s1p1_off	Orthosteric Ligand	3V2W-S1P₁-PubChem 51892645
5.00	Consensus	sensory_offon	Orthosteric Ligand	sensory_off sensory_on
5.00	Consensus	sensory_offon_gp	Orthosteric Ligand	sensory_on_gp sensory_on
5.00	Consensus	succinate_on	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
5.00	Consensus	succinate_on_gp	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
4.76	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
4.76	Single	3OAX	11-cis-Retinal	3OAX-Rhodopsin-11-cis-Retinal
4.76	Single	3RZE	Cidoxepin	3RZE-H₁-Cidoxepin
4.76	Single	3UZC	4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol	3UZC-A_2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
4.76	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
4.76	Single	4MBS	Maraviroc	4MBS-CCR5-Maraviroc
4.76	Single	4MQT	Iperoxo	4MQT-M₂-Iperoxo-LY2119620
4.76	Single	4ZUD	Olmesartan	4ZUD-AT₁-Olmesartan
4.76	Single	6A94	Zotepine	6A94-5-HT_2A-Zotepine
4.76	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
4.76	Single	6IQL	L745870	6IQL-D₄-L745870
4.76	Single	6KUX	RS-79948	6KUX-α_2a-RS-79948
4.76	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
4.76	Single	6PS5	S-Propranolol	6PS5-β₂-S-Propranolol
4.76	Single	6TPK	Retosiban	6TPK-OT-Retosiban
4.76	Single	6TPN	HTL6641	6TPN-OX₂-HTL6641
4.76	Single	6V9S	GTPL11403	6V9S-OX₁-GTPL11403
4.76	Single	7EJ8	Brimonidine	7EJ8-α_2a-Brimonidine-Go/β1/γ2
4.76	Single	7F61	PF-03654746	7F61-H₃-PF-03654746-Cholesterol
4.76	Single	7SR8	TAK-925	7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76	Single	7UL3	Famotidine	7UL3-H₂-Famotidine
4.76	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
4.76	Single	7VOD	Cariprazine	7VOD-5-HT_2A-Cariprazine
4.76	Single	7WC9	PubChem 162421364	7WC9-5-HT_2A-PubChem 162421364
4.76	Single	7WVU	fMLF	7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
4.76	Single	7XOV	SR146131	7XOV-CCK_A-SR146131-Gs/β1/γ2
4.76	Single	7YK6	PubChem 138319674	7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
4.76	Single	7ZBC	11-cis-Retinal	7ZBC-Rhodopsin-11-cis-Retinal
4.76	Single	7ZBE	11-cis-Retinal	7ZBE-Rhodopsin-11-cis-Retinal
4.76	Single	8FCZ	11-cis-Retinal	8FCZ-Rhodopsin-11-cis-Retinal
4.76	Single	8GG7	Constrained Epinephrine	8GG7-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8GGL	Constrained Epinephrine	8GGL-β₂-Constrained Epinephrine
4.76	Single	8GGM	Constrained Epinephrine	8GGM-β₂-Constrained Epinephrine
4.76	Single	8GGP	Constrained Epinephrine	8GGP-β₂-Constrained Epinephrine
4.76	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/β1/γ2
4.76	Single	8GUR	CP55,940	8GUR-CB₂-CP55,940-Gi1/β1/γ2
4.76	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	8JD6	N-(3-chlorophenyl)pyridine-2-carboxamide	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.76	Single	8JLQ	Fenoldopam	8JLQ-TA1-Fenoldopam-Gs/β1/γ2
4.76	Single	8JSP	Ulotaront	8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2
4.76	Single	8K2W	AMG487	8K2W-CXCR3-AMG487
4.76	Single	8K9K	Damgo	8K9K-μ-Damgo-Gi3/β1/γ1
4.76	Single	8K9L	Damgo	8K9L-μ-Damgo-VV9-Gi3/β1/γ1
4.76	Single	8RQL	Flufenamic acid	8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
4.76	Single	8UNL	Constrained Epinephrine	8UNL-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8UNO	Constrained Epinephrine	8UNO-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8UO1	Constrained Epinephrine	8UO1-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
4.76	Single	8V6U	PubChem 171392456	8V6U-5-HT_2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
4.76	Single	8VVG	GB18	8VVG-κ-GB18-Gi1/β1/γ2
4.76	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.76	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76	Single	8XQO	Aristolochic acid A	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.76	Single	8XQS	Flufenamic acid	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
4.76	Single	8Y62	C16:0 Ceramide	8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
4.76	Single	8ZMG	Pimavanserin	8ZMG-5-HT_2A-Pimavanserin
4.76	Single	8ZPM	AMD070	8ZPM-CXCR4-AMD070-Cholesterol
4.76	Single	8ZPN	AMD3100	8ZPN-CXCR4-AMD3100-Cholesterol
4.76	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.76	Single	9EPP	11,20-Ethanoretinal	9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
4.76	Single	9JKQ	METH	9JKQ-TA1-METH-Gs/β1/γ2
4.76	Consensus	5ht2a_off	Orthosteric Ligand	6A94-5-HT_2A-Zotepine 6A93-5-HT_2A-Risperidone 7VOD-5-HT_2A-Cariprazine 7WC8-5-HT_2A-Lumateperone 8JT8-5-HT_2A-(R)-IHCH-7179
4.76	Consensus	5ht_on_gp	Orthosteric Ligand	5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
4.76	Consensus	at1_off	Orthosteric Ligand	4YAY-AT₁-ZD-7155 4ZUD-AT₁-Olmesartan
4.76	Consensus	cb1_off	Orthosteric Ligand	5U09-CB₁-Taranabant 5TGZ-CB₁-AM6538
4.76	Consensus	cxcr3_off	Orthosteric Ligand	8K2W-CXCR3-AMG487
4.76	Consensus	ghrelin_off	Orthosteric Ligand	6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
4.76	Consensus	grh_off	Orthosteric Ligand	gnrh1_off
4.76	Consensus	opsins_off	Orthosteric Ligand	rhodopsin_off
4.76	Consensus	ot_off	Orthosteric Ligand	6TPK-OT-Retosiban
4.76	Consensus	sensory_off	Orthosteric Ligand	opsins_off
4.76	Consensus	vasop-oxy_off	Orthosteric Ligand	ot_off
4.55	Single	1HZX	11-cis-Retinal	1HZX-Rhodopsin-11-cis-Retinal
4.55	Single	2VT4	Cyanopindolol	2VT4-β₁-Cyanopindolol
4.55	Single	2Y01	Dobutamine	2Y01-β₁-Dobutamine
4.55	Single	2YCY	Cyanopindolol	2YCY-β₁-Cyanopindolol
4.55	Single	3ZPQ	4-(piperazin-1- yl)-1H-indole	3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na
4.55	Single	3ZPR	4-methyl-2-(piperazin-1-yl)	3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
4.55	Single	4YAY	ZD-7155	4YAY-AT₁-ZD-7155
4.55	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
4.55	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
4.55	Single	6DRX	Lisuride	6DRX-5-HT_2B-Lisuride
4.55	Single	6GPS	MK0812	6GPS-CCR2-MK0812
4.55	Single	6PRZ	S-Alprenolol	6PRZ-β₂-S-Alprenolol
4.55	Single	6PS2	S-Alprenolol	6PS2-β₂-S-Alprenolol
4.55	Single	6Z10	PubChem 154585554	6Z10-Succinate-PubChem 154585554
4.55	Single	7BU7	BI167107	7BU7-β₁-BI167107
4.55	Single	7CFM	P395	7CFM-GPBA-P395-Gs/β1/γ2
4.55	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/β1/γ2
4.55	Single	7F83	PF-05190457	7F83-Ghrelin-PF-05190457
4.55	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
4.55	Single	7JOZ	VFP	7JOZ-D₁-VFP-Gs/β1/γ2
4.55	Single	7RBT	PubChem 163183774	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
4.55	Single	7SQO	TAK-925	7SQO-OX₂-TAK-925-Gi1/β1/γ2
4.55	Single	7T6V	fMLFII	7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
4.55	Single	7UM6	Lisuride	7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2
4.55	Single	7VGZ	Remalteon	7VGZ-MT₁-Remalteon-Gi1/β1/γ2
4.55	Single	7VH0	Ramelteon	7VH0-MT₂-Ramelteon-Gi1/β1/γ1
4.55	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/β1/γ2
4.55	Single	7VIF	S-FTY720-P	7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2
4.55	Single	7WC7	Lisuride	7WC7-5-HT_2A-Lisuride
4.55	Single	7XJH	Isoproterenol	7XJH-β₃-Isoproterenol-Gs/β1/γ2
4.55	Single	7XTC	5-CT	7XTC-5-HT₇-5-CT-Gs/β1/γ2
4.55	Single	7YK7	DC591053	7YK7-RXFP4-DC591053-Gi2/β1/γ2
4.55	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
4.55	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
4.55	Single	8EFQ	Damgo	8EFQ-μ-Damgo-Gi1/β1/γ2
4.55	Single	8GCM	L902688	8GCM-EP₄-L902688-Gi1/β1/γ2
4.55	Single	8JD0	NAM563	8JD0-mGlu2; mGlu3-Glutamate-NAM563
4.55	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.55	Single	8UH3	Setiptiline	8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
4.55	Single	8XQL	Aristolochic acid A	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.55	Single	8YH5	Riboprine	8YH5-A_3A-Riboprine-Gi1/β1/γ2
4.55	Single	8YIC	SAR247799	8YIC-S1P₁-SAR247799-Gi1/β1/γ2
4.55	Single	8ZBE	Octreotide	8ZBE-SST5-Octreotide-Gi1/β1/γ1
4.55	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.55	Single	9B9Z	A1AKO	9B9Z-CB₁-A1AKO
4.55	Single	9CHX	S-Carazolol	9CHX-β₂-S-Carazolol
4.55	Consensus	5ht5_on	Orthosteric Ligand	5ht5a_on
4.55	Consensus	5ht5a_on	Orthosteric Ligand	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
4.55	Consensus	5ht7_on	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2
4.55	Consensus	5ht7_on_gp	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2
4.55	Consensus	alicarboxylic_off	Orthosteric Ligand	succinate_off
4.55	Consensus	ccr2_off	Orthosteric Ligand	6GPS-CCR2-MK0812
4.55	Consensus	gi_orexin	Orthosteric Ligand	7SQO-OX₂-TAK-925-Gi1/β1/γ2
4.55	Consensus	succinate_off	Orthosteric Ligand	6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
4.35	Single	2Y00	Dobutamine	2Y00-β₁-Dobutamine
4.35	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
4.35	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
4.35	Single	5T1A	PubChem 68764898; PubChem 12093170	5T1A-CCR2-PubChem 68764898; PubChem 12093170
4.35	Single	5YHL	PubChem 135121352	5YHL-EP₄-PubChem 135121352
4.35	Single	5YWY	ONO-AE3-208	5YWY-EP₄-ONO-AE3-208
4.35	Single	6E67	BI167107	6E67-β₂-BI167107-Gs (fused)
4.35	Single	6GPX	MK0812	6GPX-CCR2-MK0812
4.35	Single	6HLP	Netupitant	6HLP-NK₁-Netupitant
4.35	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
4.35	Single	6ME8	2-Phenylmelatonin	6ME8-MT₂-2-Phenylmelatonin
4.35	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/β1/γ2
4.35	Single	7BB7	AVP	7BB7-V₂-AVP-Gs/β1/γ2
4.35	Single	7C4S	S1P	7C4S-S1P₃-S1P
4.35	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/β1/γ2
4.35	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/β1/γ2
4.35	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/β1/γ2
4.35	Single	7EUO	fMLF	7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
4.35	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/β1/γ2
4.35	Single	7VFX	fMLF	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
4.35	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35	Single	8C9W	Etrumadenant	8C9W-A_2A-Etrumadenant
4.35	Single	8JXS	PF-6142	8JXS-D₁-PF-6142
4.35	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
4.35	Single	8S4D	CMF-019	8S4D-Apelin-CMF-019
4.35	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
4.35	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
4.35	Single	8TH4	Losartan	8TH4-AT₁-Losartan-AT118-L Nanobody
4.35	Single	8XQP	Cholesterol	8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.35	Single	9DQJ	EP-3945	9DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	9EAH	Olmesartan	9EAH-AT₁-Olmesartan-Nanobody AT209
4.35	Consensus	blt1_off	Orthosteric Ligand	5X33-BLT₁-BIIL260 7K15-BLT₁-MKD046-Na
4.35	Consensus	blt_off	Orthosteric Ligand	blt1_off
4.35	Consensus	cb2_on	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2
4.35	Consensus	cb2_on_gp	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2
4.35	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
4.35	Consensus	ep4_off	Orthosteric Ligand	5YWY-EP₄-ONO-AE3-208 5YHL-EP₄-PubChem 135121352
4.35	Consensus	ep_off	Orthosteric Ligand	ep4_off
4.35	Consensus	fpr1-alx_on	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
4.35	Consensus	fpr1-alx_on_gp	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
4.35	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
4.35	Consensus	lipid_on_gp	Orthosteric Ligand	cannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
4.35	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on p2y_on
4.35	Consensus	rxfp4_on	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
4.35	Consensus	rxfp4_on_gp	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
4.35	Consensus	s1p5_off	Orthosteric Ligand	7YXA-S1P₅-ONO-5430608
4.35	Consensus	s1p_off	Orthosteric Ligand	s1p1_off s1p5_off
4.17	Single	3P0G	BI167107	3P0G-β₂-BI167107
4.17	Single	3SN6	BI167107	3SN6-β₂-BI167107-Gs/β1/γ2
4.17	Single	5XR8	AM841	5XR8-CB₁-AM841
4.17	Single	5XRA	AM11542	5XRA-CB₁-AM11542
4.17	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
4.17	Single	6DDE	Damgo	6DDE-μ-Damgo-Gi1/β1/γ2
4.17	Single	6E59	L-760735	6E59-NK₁-L-760735
4.17	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
4.17	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
4.17	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/β1/γ2
4.17	Single	7B6W	Cyclazosin	7B6W-α_1b-Cyclazosin
4.17	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/β1/γ2
4.17	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/β1/γ2
4.17	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/β1/γ2
4.17	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/β1/γ2
4.17	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
4.17	Single	7XOW	Gastrin	7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2
4.17	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/β1/γ2
4.17	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/β1/γ2
4.17	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
4.17	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
4.17	Single	8ID6	Oleic acid	8ID6-FFA4-Oleic acid-Gi1/β1/γ2
4.17	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.17	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/β1/γ2
4.17	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.17	Single	8WU1	PubChem 119025665	8WU1-CB₁-PubChem 119025665-Arrestin2
4.17	Single	8XVL	Zibotentan	8XVL-ET_A-Zibotentan
4.17	Single	9B65	KCA	9B65-CB₁-KCA-Gi1/β1/γ2
4.17	Single	9BJK	NAM	9BJK-μ-Naloxone-NAM
4.17	Consensus	class-a_off	Orthosteric Ligand	sensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
4.17	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 6KPG-CB₁-AM841-Gi1/β1/γ2
4.17	Consensus	gi_relaxin	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
4.17	Consensus	motilin_on	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
4.17	Consensus	npy_off	Orthosteric Ligand	npy1_off npy2_off
4.17	Consensus	relaxin_on	Orthosteric Ligand	rxfp4_on
4.17	Consensus	relaxin_on_gp	Orthosteric Ligand	rxfp4_on_gp
4.17	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
4.00	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
4.00	Single	5F8U	Cyanopindolol	5F8U-β₁-Cyanopindolol
4.00	Single	5UNH	PubChem 126456406	5UNH-AT₂-PubChem 126456406
4.00	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/β1/γ2
4.00	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
4.00	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
4.00	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/β1/γ2
4.00	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
4.00	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Single	7L1V	PubChem 155491009	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Single	7SHE	PI; PE	7SHE-GPR158-PI; PE
4.00	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
4.00	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/β1/γ2
4.00	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
4.00	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
4.00	Single	8IBU	Erythromycin-A	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Single	8ID9	Eicosapentaenoic acid	8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
4.00	Single	8J6D	EP141	8J6D-C3a_B-EP141-Go/β1/γ2
4.00	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
4.00	Single	8JJP	Chemerin	8JJP-CML2-Chemerin-Gi1/β1/γ2
4.00	Single	8JWY	2-118	8JWY-A_2A-2-118
4.00	Single	8JWZ	AB928	8JWZ-A_2A-AB928-Na
4.00	Single	8T3Q	Docosa-4,7,10,13,16,19-Hexaenoic acid	8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00	Single	8W1V	PubChem 171716265	8W1V-β₂-PubChem 171716265
4.00	Single	8X8N	Octreotide	8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.00	Single	8XQS	Cholesterol	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
4.00	Single	9GYO	P395	9GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
4.00	Single	9L3W	Retinoic acid receptor responder protein 2	9L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
4.00	Consensus	cannabinoid_on	Orthosteric Ligand	cb2_on cb1_on
4.00	Consensus	cannabinoid_on_gp	Orthosteric Ligand	cb2_on_gp cb1_on_gp
4.00	Consensus	cb1_on	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
4.00	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
4.00	Consensus	leukotriene_off	Orthosteric Ligand	blt_off cyslt_off
4.00	Consensus	motilin_on_gp	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Consensus	orexin_on	Orthosteric Ligand	ox2_on
4.00	Consensus	s1p1_on	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
4.00	Consensus	s1p1_on_gp	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
4.00	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
3.85	Single	4NC3	Ergotamine	4NC3-5-HT_2B-Ergotamine
3.85	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
3.85	Single	6DDF	Damgo	6DDF-μ-Damgo-Gi1/β1/γ2
3.85	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/β1/γ2
3.85	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/β1/γ2
3.85	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
3.85	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
3.85	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/β1/γ2
3.85	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.85	Single	7SHF	PI; PE	7SHF-GPR158-PI; PE-B5; RGS7
3.85	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/β1/γ2
3.85	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
3.85	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/β1/γ2
3.85	Single	8GAG	PubChem 170838490	8GAG-CB₁-PubChem 170838490-Gi1/β1/γ2
3.85	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/β1/γ2
3.85	Single	8I95	EP54	8I95-C3a_B-EP54-Go/β1/γ2
3.85	Single	8K2X	CXCL10	8K2X-CXCR3-CXCL10-Gi1/β1/γ2
3.85	Single	9EAI	Losartan	9EAI-AT₁-Losartan-Nanobody AT209
3.85	Consensus	cb1_on_gp	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
3.85	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
3.85	Consensus	cck_on_gp	Orthosteric Ligand	ccka_on_gp cckb_on_gp
3.85	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
3.85	Consensus	ccka_on_gp	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
3.85	Consensus	chemerin_on	Orthosteric Ligand	cml1_on
3.85	Consensus	gi_s1p	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7EW3-S1P₃-S1P-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EW1-S1P₅-Siponimod-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
3.85	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85	Consensus	orexin_on_gp	Orthosteric Ligand	ox2_on_gp
3.85	Consensus	peptide_off	Orthosteric Ligand	cck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
3.85	Consensus	prostanoid_off	Orthosteric Ligand	ep_off dp_off
3.70	Single	5VBL	Apelin mimetic peptide agonist	5VBL-Apelin-Apelin mimetic peptide agonist
3.70	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/β1/γ2
3.70	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
3.70	Single	7XY6	BAY 60-6583	7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
3.70	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/β1/γ2
3.70	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/β1/γ2
3.70	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
3.70	Single	8XZF	WN561	8XZF-Apelin-WN561-Gi1/β1/γ2
3.70	Single	9ERX	D9-THC analog	9ERX-CB₁-D9-THC analog-Gi1/β1/γ2
3.70	Consensus	cxcr_on_gp	Orthosteric Ligand	cxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
3.70	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
3.70	Consensus	formylpeptide_on	Orthosteric Ligand	fpr2-alx_on fpr1-alx_on
3.70	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
3.70	Consensus	kiss1_on	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
3.70	Consensus	kisspeptin_on	Orthosteric Ligand	kiss1_on
3.70	Consensus	nmur1_on	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70	Consensus	ox2_on_gp	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
3.57	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
3.57	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
3.57	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
3.57	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57	Single	7W56	Neuromedin-S	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/β1/γ2
3.57	Single	8G59	TUG-891	8G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
3.57	Single	8GHV	AMG315	8GHV-CB₁-AMG315-Gi1/β1/γ2
3.57	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/β1/γ2
3.57	Single	8K3Z	CXCL12	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
3.57	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
3.57	Single	8WZ2	Orexigenic Neuropeptide QRFP	8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.57	Single	8ZJD	Kisspeptin-10	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
3.57	Single	9L3Y	Retinoic acid receptor responder protein 2	9L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
3.57	Consensus	chemerin_on_gp	Orthosteric Ligand	cml1_on_gp
3.57	Consensus	cml1_on	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
3.57	Consensus	cxcr4_on	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
3.57	Consensus	gi_chemerin	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
3.57	Consensus	gq_kisspeptin	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
3.57	Consensus	kiss1_on_gp	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
3.57	Consensus	kisspeptin_on_gp	Orthosteric Ligand	kiss1_on_gp
3.57	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
3.57	Consensus	lpl_on_gp	Orthosteric Ligand	s1p_on_gp lpa_on_gp
3.57	Consensus	nmur1_on_gp	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
3.57	Consensus	nop_on_gp	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
3.57	Consensus	somatostatin_off	Orthosteric Ligand	sst2_off
3.45	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
3.45	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
3.45	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
3.45	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/β1/γ2
3.45	Single	7SHE	PI; PE	7SHE-GPR158-PI; PE
3.45	Single	7SHF	PI; PE	7SHF-GPR158-PI; PE-B5; RGS7
3.45	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
3.45	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/β1/γ2
3.45	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
3.45	Single	8F7Q	Beta-Endorphin	8F7Q-μ-β-Endorphin-Gi1/β1/γ2
3.45	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/β1/γ2
3.45	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/β1/γ2
3.45	Single	8K6O	Pro-neuropeptide-Y	8K6O-Y₁-Pro-neuropeptide-Y-Gi2/β1/γ1
3.45	Single	8WSS	Pro-MCH	8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
3.45	Single	8Z7J	Agonistic antibody	8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
3.45	Consensus	cckb_on	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
3.45	Consensus	dop_on_gp	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
3.45	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
3.45	Consensus	s1p3_on_gp	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
3.45	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
3.33	Single	6VN7	PACAP	6VN7-VPAC₁-PACAP-Gs/β1/γ2
3.33	Single	7F4D	Alpha-MSH	7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2
3.33	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
3.33	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.33	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/β1/γ2
3.33	Single	8XIR	Pasireotide	8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
3.33	Single	8XZG	Apelin-13	8XZG-Apelin-Apelin-13-Gi1/β1/γ2
3.33	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/β1/γ2
3.33	Single	9K27	PrRP31	9K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
3.33	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
3.33	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
3.33	Consensus	cckb_on_gp	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
3.33	Consensus	cxcr4_on_gp	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
3.33	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
3.33	Consensus	gs_class-a	Orthosteric Ligand	gs_peptide gs_nucleotide gs_amine
3.33	Consensus	peptide_offon	Orthosteric Ligand	peptide_off peptide_on
3.23	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
3.23	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
3.23	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/β1/γ2
3.23	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/β1/γ2
3.23	Single	7DW9	AVP	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
3.23	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
3.23	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
3.23	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
3.23	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
3.23	Single	7T10	Somatostatin-14	7T10-SST2-Somatostatin-14-Gi3/β1/γ2
3.23	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
3.23	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2
3.23	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
3.23	Single	8XWQ	Endothelin-1	8XWQ-ET_B-Endothelin-1-Gi1/β1/γ2
3.23	Single	8YW3	Retatrutide	8YW3-GLP-1-Retatrutide-Gs/β1/γ2
3.23	Single	8YW4	Retatrutide	8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
3.23	Consensus	angiotensin_on_gp	Orthosteric Ligand	at1_on_gp
3.23	Consensus	apelin_on	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
3.23	Consensus	apelin_on_gp	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
3.23	Consensus	at1_on_gp	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
3.23	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
3.23	Consensus	gs_vasop-oxy	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
3.23	Consensus	neuromedin-u_on	Orthosteric Ligand	nmur1_on nmur2_on
3.23	Consensus	peptide_offon_gp	Orthosteric Ligand	peptide_on_gp peptide_off
3.23	Consensus	protein_on	Orthosteric Ligand	chemokine_on chemerin_on
3.23	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
3.23	Consensus	v2_on_gp	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
3.23	Consensus	vasop-oxy_on	Orthosteric Ligand	v2_on
3.23	Consensus	vasop-oxy_on_gp	Orthosteric Ligand	v2_on_gp
3.12	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/β1/γ2
3.12	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
3.12	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/β1/γ2
3.12	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
3.12	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
3.12	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/β1/γ2
3.12	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/β1/γ2
3.12	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
3.12	Single	8XQE	Apelin-13	8XQE-Apelin-Apelin-13-Gi1/β1/γ2
3.12	Single	8XVH	Endothelin-1	8XVH-ET_B-Endothelin-1-chim(Gs-CtGq)/β1/γ2
3.12	Single	8ZPS	PrRP20	8ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12	Single	8ZRT	ET-1	8ZRT-ET_B-ET-1
3.12	Consensus	chemokine_off	Orthosteric Ligand	ccr_off cxcr_off
3.12	Consensus	cxcr_off	Orthosteric Ligand	cxcr3_off cxcr4_off
3.12	Consensus	gi_apelin	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
3.12	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
3.12	Consensus	mc1_on_gp	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
3.12	Consensus	neuromedin-u_on_gp	Orthosteric Ligand	nmur1_on_gp nmur2_on_gp
3.03	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
3.03	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
3.03	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
3.03	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
3.03	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.03	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
3.03	Single	8XQF	Apelin-13	8XQF-Apelin-Apelin-13-Gi1/β1/γ2
3.03	Single	8XVE	BQ3020	8XVE-ET_B-BQ3020-chim(Gs-CtGq)/β1/γ2
3.03	Single	9J1P	g1:Ox	9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
3.03	Consensus	ccr_off	Orthosteric Ligand	ccr2_off ccr5_off
3.03	Consensus	gi_peptide	Orthosteric Ligand	gi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
3.03	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
3.03	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
3.03	Consensus	npy4_on_gp	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
3.03	Consensus	protein_on_gp	Orthosteric Ligand	chemokine_on_gp chemerin_on_gp
2.94	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
2.94	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
2.94	Single	7F53	Alpha-MSH	7F53-MC₄-α-MSH-Gs/β1/γ2
2.94	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
2.94	Single	7YOO	Neuropeptide-Y	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
2.94	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
2.94	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
2.94	Single	8XWP	Endothelin-1	8XWP-ET_B-Endothelin-1-Gi1/β1/γ2
2.94	Single	8ZJG	Chemerin	8ZJG-CML1-Chemerin-Gi1/β1/γ2
2.94	Single	9K26	PrRP31	9K26-PrRP-PrRP31-Gi1/β1/γ2
2.94	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
2.94	Consensus	npy2_on_gp	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
2.94	Consensus	peptide_on	Orthosteric Ligand	cck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
2.94	Consensus	peptide_on_gp	Orthosteric Ligand	cck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
2.86	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
2.86	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/β1/γ2
2.86	Single	7VGX	Neuropeptide-Y	7VGX-Y₁-Neuropeptide-Y-Gi1/β1/γ2
2.86	Single	8Y52	BA1	8Y52-BB₃-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
2.78	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
2.78	Single	8ZJE	TAK-448	8ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
2.78	Consensus	gi_npy	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
2.78	Consensus	npy_on	Orthosteric Ligand	npy1_on npy2_on npy4_on
2.78	Consensus	npy_on_gp	Orthosteric Ligand	npy1_on_gp npy2_on_gp npy4_on_gp
2.63	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/β1/γ2
2.63	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
2.63	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
2.63	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_melanocortin gs_vasop-oxy
2.56	Single	7X9A	Neuropeptide-Y	7X9A-Y₁-Neuropeptide-Y-Gi1/β1/γ2
2.56	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/β1/γ2
2.56	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/β1/γ2

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:G628	R:R:S654	3.71	0	No	No	6	7	2	1
R:R:G628	R:R:V806	1.84	0	No	No	6	8	2	1
R:R:A810	R:R:Y629	4	0	No	Yes	7	8	1	2
R:R:G652	R:R:P655	4.06	0	No	Yes	5	8	2	1
R:R:P655	R:R:S654	3.56	14	Yes	No	8	7	1	1
R:R:S654	W:W:?1	5.64	14	No	Yes	7	0	1	0
R:R:N747	R:R:P655	6.52	0	No	Yes	7	8	2	1
R:R:P655	W:W:?1	12.34	14	Yes	Yes	8	0	1	0
R:R:S658	R:R:Y659	3.82	0	No	Yes	6	7	2	1
R:R:L750	R:R:Y659	2.34	0	No	Yes	9	7	2	1
R:R:I751	R:R:Y659	6.04	14	No	Yes	8	7	1	1
R:R:Y659	W:W:?1	1.76	14	Yes	Yes	7	0	1	0
R:R:L744	W:W:?1	8.32	0	No	Yes	8	0	1	0
R:R:G748	R:R:I751	1.76	14	No	No	5	8	1	1
R:R:G748	W:W:?1	5.14	14	No	Yes	5	0	1	0
R:R:I751	W:W:?1	4.29	14	No	Yes	8	0	1	0
R:R:L752	R:R:T755	2.95	14	No	No	3	8	1	2
R:R:F756	R:R:L752	2.44	14	No	No	4	3	2	1
R:R:L752	W:W:?1	2.08	14	No	Yes	3	0	1	0
R:R:F756	R:R:T755	3.89	14	No	No	4	8	2	2
R:R:S805	W:W:?1	5.64	0	No	Yes	8	0	1	0
R:R:V806	W:W:?1	5.6	0	No	Yes	8	0	1	0
R:R:S809	W:W:?1	13.54	0	No	Yes	9	0	1	0
R:R:A810	W:W:?1	2.37	0	No	Yes	7	0	1	0
R:R:G745	R:R:L744	1.71	0	No	No	5	8	2	1
R:R:A813	W:W:?1	1.18	0	No	Yes	7	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
50.00	Single	8X0B	VU0424465	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
50.00	Single	8X0C	VU0424465	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
50.00	Single	8X0C	VU0424465	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
47.06	Single	4OO9	Mavoglurant	4OO9-mGlu₅-Mavoglurant
47.06	Single	7P2L	4YI	7P2L-mGlu₅-4YI
47.06	Single	8TAO	CDPPB	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
46.67	Single	6FFI	MMPEP	6FFI-mGlu₅-MMPEP
43.75	Single	6FFH	Fenobam	6FFH-mGlu₅-Fenobam
42.11	Single	5CGD	HTL14242	5CGD-mGlu₅-HTL14242
41.18	Single	8X0D	VU0424465	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
41.18	Single	8X0D	VU0424465	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
38.89	Single	8X0B	VU0424465	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
33.33	Single	5CGC	HTL14242	5CGC-mGlu₅-HTL14242
31.58	Single	8X0F	VU0424465	8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
28.00	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
23.81	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
23.81	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
22.73	Single	8J19	LY237	8J19-GPR84-LY237-Gi1/β1/γ2
22.73	Single	8XVJ	Macitentan	8XVJ-ET_A-Macitentan
22.22	Single	8PM2	DMCH	8PM2-TA7-DMCH-Gs/β1/γ2
21.74	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05	Single	4U16	N-Methyl-Scopolamine	4U16-M₃-N-Methyl-Scopolamine
21.05	Single	5DSG	Tiotropium	5DSG-M₄-Tiotropium
21.05	Consensus	m4_off	Orthosteric Ligand	5DSG-M₄-Tiotropium
20.83	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
20.00	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
20.00	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
20.00	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
20.00	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/β1/γ2
20.00	Single	8E9Z	Iperoxo	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/β1/γ2
20.00	Consensus	gq_muscarinic	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
20.00	Consensus	m1_on	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
20.00	Consensus	m2_off	Orthosteric Ligand	5ZKC-M₂-N-Methyl-Scopolamine 5ZK3-M₂-3-quinuclidinyl-benzilate 5ZKB-M₂-AF-DX 384
19.05	Single	5V54	Methiothepin	5V54-5-HT_1B-Methiothepin
19.05	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
19.05	Single	6OIJ	Iperoxo	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
19.05	Single	7TRQ	Iperoxo	7TRQ-M₄-Iperoxo-VU0467154-Gi1/β1/γ2
19.05	Single	8EA0	Iperoxo	8EA0-M₃-Iperoxo
19.05	Single	8IUK	PGF2-alpha	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
19.05	Single	8JXX	Clobenpropit	8JXX-H₄-Clobenpropit-Gi1/β1/γ2
19.05	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/β1/γ2
19.05	Consensus	5ht1_off	Orthosteric Ligand	5ht1b_off
19.05	Consensus	5ht1b_off	Orthosteric Ligand	5V54-5-HT_1B-Methiothepin
19.05	Consensus	5ht_off	Orthosteric Ligand	5ht2_off 5ht1_off
19.05	Consensus	h4_on_gp	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2 8JXX-H₄-Clobenpropit-Gi1/β1/γ2
19.05	Consensus	m1_on_gp	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
19.05	Consensus	muscarinic_off	Orthosteric Ligand	m2_off m3_off m4_off m5_off m1_off
18.75	Single	8IW7	2-Phenylethylamine	8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
18.75	Single	8YN9	Histamine	8YN9-H₄-Histamine-Gi1/β1/γ2
18.75	Single	8YUU	Histamine	8YUU-H₃-Histamine-Gi1/β1/γ1
18.75	Consensus	h3_on	Orthosteric Ligand	8YUU-H₃-Histamine-Gi1/β1/γ1
18.75	Consensus	h3_on_gp	Orthosteric Ligand	8YUU-H₃-Histamine-Gi1/β1/γ1
18.18	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
18.18	Single	5CXV	Tiotropium	5CXV-M₁-Tiotropium
18.18	Single	5X33	BIIL260	5X33-BLT₁-BIIL260
18.18	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
18.18	Single	7WCM	MBX-2982	7WCM-GPR119-MBX-2982-Gs/β1/γ2
18.18	Single	7WCN	AR231453	7WCN-GPR119-AR231453-Gs/β1/γ2
18.18	Single	8E9W	2-Deoxycytidine	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18	Consensus	m1_off	Orthosteric Ligand	5CXV-M₁-Tiotropium
17.65	Single	7YFD	Imetit	7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65	Single	8HN8	Histamine	8HN8-H₄-Histamine-Gi1/β1/γ2
17.65	Single	8Y0N	VUF11418	8Y0N-CXCR3-VUF11418-Go1/β1/γ2
17.65	Single	8YN5	Histamine	8YN5-H₃-Histamine-Gi1/β1/γ2
17.65	Single	8YN6	Imetit	8YN6-H₃-Imetit-Gi1/β1/γ2
17.65	Single	8YN7	Immethridine	8YN7-H₃-Immethridine-Go1/β1/γ2
17.65	Single	8YUV	Immepip	8YUV-H₃-Immepip-Gi1/β1/γ2
17.65	Single	9EPR	Retinal	9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
17.65	Consensus	h4_on	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2 8JXX-H₄-Clobenpropit-Gi1/β1/γ2
17.39	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
17.39	Single	6BQH	Ritanserin	6BQH-5-HT_2C-Ritanserin
17.39	Single	6K1Q	IRL2500	6K1Q-ET_B-IRL2500
17.39	Single	7U2K	C6-guano	7U2K-μ-C6-guano-Gi1/β1/γ2
17.39	Single	7XZ6	APD668	7XZ6-GPR119-APD668-Gs/β1/γ2
17.39	Consensus	5ht2c_off	Orthosteric Ligand	6BQH-5-HT_2C-Ritanserin
17.39	Consensus	fp-alpha_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39	Consensus	fp-alpha_on_gp	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/β1/γ2
16.67	Single	6PT3	DPI-287	6PT3-δ-DPI-287
16.67	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
16.67	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/β1/γ2
16.67	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/β1/γ2
16.67	Single	7EJ0	L-Norepinephrine	7EJ0-α_2a-L-Norepinephrine-Go/β1/γ2
16.67	Single	7T8X	Acetylcholine	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.67	Single	7T90	Acetylcholine	7T90-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.67	Single	7T96	Acetylcholine	7T96-M₂-Acetylcholine-LY2119620-Go/β1/γ2
16.67	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
16.67	Single	7VVO	PTH	7VVO-PTH1-PTH-Gs/β1/γ2
16.67	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/β1/γ2
16.67	Single	8HOC	Imetit	8HOC-H₄-Imetit-Gi1/β1/γ2
16.67	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67	Single	8IW4	Spermidine	8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
16.67	Single	8IWE	Spermidine	8IWE-TA9-Spermidine
16.67	Single	8Y0H	VUF11418	8Y0H-CXCR3-VUF11418
16.67	Single	8YNA	Immepip	8YNA-H₄-Immepip-Gi1/β1/γ
16.67	Consensus	histamine_on	Orthosteric Ligand	h1_on h2_on h3_on h4_on
16.67	Consensus	histamine_on_gp	Orthosteric Ligand	h1_on_gp h2_on_gp h3_on_gp h4_on_gp
16.67	Consensus	m2_on	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.67	Consensus	m2_on_gp	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.00	Single	7QA8	Peptide	7QA8-STE2-Peptide
16.00	Single	7QA8	Peptide	7QA8-STE2-Peptide
15.79	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
15.79	Single	7CMV	PD128907	7CMV-D₃-PD128907-Gi1/β1/γ2
15.79	Single	7T94	Acetylcholine	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
15.79	Single	7TRS	Acetylcholine	7TRS-M₄-Acetylcholine-Gi1/β1/γ2
15.79	Single	8DPG	Psilocin	8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79	Single	8HNM	VUF11222	8HNM-CXCR3-VUF11222-Gi1/β1/γ2
15.79	Single	8Y01	Retinal	8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
15.79	Single	8YN8	Proxyfan	8YN8-H₃-Proxyfan-Go1/β1/γ2
15.79	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
15.15	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
15.15	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
15.00	Single	4DAJ	Tiotropium	4DAJ-M₃-Tiotropium
15.00	Single	5YC8	N-Methyl-Scopolamine	5YC8-M₂-N-Methyl-Scopolamine
15.00	Single	5ZK8	N-Methyl-Scopolamine	5ZK8-M₂-N-Methyl-Scopolamine
15.00	Single	5ZKC	N-Methyl-Scopolamine	5ZKC-M₂-N-Methyl-Scopolamine
15.00	Single	6TOT	Lemborexant	6TOT-OX₁-Lemborexant
15.00	Single	6WHA	DB13948	6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
15.00	Single	7UM5	5-CT	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/β1/γ2
15.00	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/β1/γ2
15.00	Single	8T1W	CVN424	8T1W-GPR6-CVN424
15.00	Single	8X64	Desloratadine	8X64-H₁-Desloratadine
15.00	Single	8X9T	AP503	8X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
15.00	Consensus	gi_histamine	Orthosteric Ligand	8JXX-H₄-Clobenpropit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8YUU-H₃-Histamine-Gi1/β1/γ1 8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2
15.00	Consensus	muscarinic_on	Orthosteric Ligand	m2_on m3_on m4_on m1_on
15.00	Consensus	muscarinic_on_gp	Orthosteric Ligand	m2_on_gp m3_on_gp m4_on_gp m1_on_gp
14.81	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
14.29	Single	4WW3	All-trans-Retinal	4WW3-Rhodopsin-All-trans-Retinal
14.29	Single	4ZJ8	Suvorexant	4ZJ8-OX₁-Suvorexant
14.29	Single	5JQH	S-Carazolol	5JQH-β₂-S-Carazolol
14.29	Single	5ZK3	3-quinuclidinyl-benzilate	5ZK3-M₂-3-quinuclidinyl-benzilate
14.29	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/β1/γ1
14.29	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
14.29	Single	6OIK	Iperoxo	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
14.29	Single	6PS6	Timolol	6PS6-β₂-Timolol
14.29	Single	6TO7	Suvorexant	6TO7-OX₁-Suvorexant-Na
14.29	Single	6TP6	Filorexant	6TP6-OX₁-Filorexant
14.29	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
14.29	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
14.29	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
14.29	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/β1/γ2
14.29	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29	Single	7TRK	Iperoxo	7TRK-M₄-Iperoxo-Gi1/β1/γ2
14.29	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/β1/γ2
14.29	Single	8EFB	Oliceridine	8EFB-μ-Oliceridine-Gi1/β1/γ2
14.29	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
14.29	Single	8J18	(3R)-3-Hydroxydodecanoic acid	8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
14.29	Single	8YNS	SNAP-94847	8YNS-MCH1-SNAP-94847
14.29	Single	8ZMF	A1L10	8ZMF-5-HT_2C-A1L10
14.29	Single	8ZRK	GSK-1292263	8ZRK-GPR119-GSK-1292263-Gs/β1/γ2
14.29	Single	9JR3	PTH	9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29	Consensus	m3_on	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29	Consensus	m3_on_gp	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/β1/γ2
13.64	Single	2YDV	NECA	2YDV-A_2A-NECA
13.64	Single	3UON	3-quinuclidinyl-benzilate	3UON-M₂-3-quinuclidinyl-benzilate
13.64	Single	4U15	Tiotropium	4U15-M₃-Tiotropium
13.64	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
13.64	Single	5G53	NECA	5G53-A_2A-NECA-Gs
13.64	Single	5ZKB	AF-DX 384	5ZKB-M₂-AF-DX 384
13.64	Single	6OL9	Tiotropium	6OL9-M₅-Tiotropium
13.64	Single	7EW4	CYM5541	7EW4-S1P₃-CYM5541-Gi1/β1/γ2
13.64	Single	7T2H	Lofentanil	7T2H-μ-Lofentanil-Gi1/β1/γ2
13.64	Single	7U2L	PubChem 163201242	7U2L-μ-PubChem 163201242-Gi1/β1/γ2
13.64	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2
13.64	Single	8EF5	Fentanyl	8EF5-μ-Fentanyl-Gi1/β1/γ2
13.64	Single	8IRU	Rotigotine	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.64	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/β1/γ2
13.64	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/β1/γ2
13.64	Single	8T1V	PubChem 118310209	8T1V-GPR6-PubChem 118310209-Na
13.64	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
13.64	Single	8XQT	Cholesterol	8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
13.64	Single	8YNT	SNAP-94847	8YNT-MCH1-SNAP-94847
13.64	Single	8ZR5	Firuglipel	8ZR5-GPR119-Firuglipel-Gs/β1/γ2
13.64	Consensus	d4_on_gp	Orthosteric Ligand	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.64	Consensus	m3_off	Orthosteric Ligand	4U15-M₃-Tiotropium 4U16-M₃-N-Methyl-Scopolamine 5ZHP-M₃-PubChem 134828589
13.64	Consensus	m5_off	Orthosteric Ligand	6OL9-M₅-Tiotropium
13.33	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
13.04	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
13.04	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
13.04	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
13.04	Single	7DFP	Spiperone	7DFP-D₂-Spiperone
13.04	Single	7EPE	NAM563	7EPE-mGlu2; mGlu2-NAM563
13.04	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
13.04	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
13.04	Single	8FYE	4-F,5-MeO-PyrT	8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
13.04	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/β1/γ2
13.04	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/β1/γ2
13.04	Single	8GTM	BMK-C203	8GTM-CRF₁-BMK-C203
13.04	Single	8VHF	MBX-2982	8VHF-GPR119-MBX-2982-Gs/β1/γ2
13.04	Single	8XJN	Cloprosetnol	8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04	Consensus	gi_amine	Orthosteric Ligand	gi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
13.04	Consensus	gi_muscarinic	Orthosteric Ligand	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2
12.90	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/β1/γ2
12.82	Single	8F0J	Pramlintide Analogue San45	8F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
12.50	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
12.50	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/β1/γ2
12.50	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
12.50	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/β1/γ1
12.50	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
12.50	Single	7SK7	CCX662	7SK7-ACKR3-CXCL12-CCX662
12.50	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/β1/γ2
12.50	Single	8DPH	Lorcaserin	8DPH-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
12.50	Single	8E9Y	Clozapine-N-oxide	8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50	Single	8F0K	Pramlintide Analogue San385	8F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
12.50	Single	8F2B	Pramlintide Analogue San45	8F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
12.50	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
12.50	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/β1/γ2
12.50	Single	8GEI	Constrained Epinephrine	8GEI-β₂-Constrained Epinephrine-Gs/β1/γ2
12.50	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Single	8IWM	2-Phenylethylamine	8IWM-TA9-2-Phenylethylamine
12.50	Single	8WC5	Tetramethylammonium Ion	8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
12.50	Single	8XJK	Cloprosetnol	8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Single	8XJO	U46619	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Consensus	prostanoid_on	Orthosteric Ligand	tp_on fp-alpha_on
12.50	Consensus	prostanoid_on_gp	Orthosteric Ligand	tp_on_gp fp-alpha_on_gp
12.50	Consensus	tp_on	Orthosteric Ligand	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Consensus	tp_on_gp	Orthosteric Ligand	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
12.00	Single	3NY9	ICI118-551	3NY9-β₂-ICI118-551
12.00	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
12.00	Single	5EE7	MK0893	5EE7-Glucagon-MK0893
12.00	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
12.00	Single	7SK9	CCX662	7SK9-ACKR3-CCX662
12.00	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
12.00	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
11.76	Single	7EJK	Oxymetazoline	7EJK-α_2a-Oxymetazoline-Go/β1/γ2
11.76	Single	7F23	Dopamine	7F23-D₁-Dopamine-GDP-Gs/β1/γ2
11.76	Single	8DPI	Lorcaserin	8DPI-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/β1/γ2
11.76	Single	8FLU	Long-Acting PTH	8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
11.76	Single	8GGF	Constrained Epinephrine	8GGF-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76	Single	8ITF	DMCHA	8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
11.76	Single	8J6Q	Beta-Hydroxybutyrate	8J6Q-HCA₂-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
11.76	Single	8JXT	Histamine	8JXT-H₄-Histamine-PO4-Gi1/β1/γ2
11.76	Single	8WC6	2-Phenylethylamine	8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
11.76	Single	8WC9	ZH8651	8WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76	Single	8XQP	Aristolochic acid A	8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
11.54	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/β1/γ2
11.54	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/β1/γ2
11.54	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
11.54	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
11.54	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
11.54	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
11.54	Single	8WDT	photoNECA	8WDT-A_2A-photoNECA
11.43	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/β1/γ2
11.11	Single	3AYM	All-trans-Retinal	3AYM-Rhodopsin-All-trans-Retinal
11.11	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
11.11	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
11.11	Single	6QNO	All-trans-Retinal	6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
11.11	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.11	Single	7DFL	Histamine	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
11.11	Single	7E2Y	Serotonin	7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2
11.11	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/β1/γ2
11.11	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
11.11	Single	7V68	Iperoxo	7V68-M₄-Iperoxo-PubChem 57664406-Gi1/β1/γ2
11.11	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/β1/γ2
11.11	Single	7YFC	Histamine	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	8DPF	Lorcaserin	8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11	Single	8GGY	Constrained Epinephrine	8GGY-β₂-Constrained Epinephrine
11.11	Single	8H2G	Niacin	8H2G-HCA₂-Niacin-Gi1/β1/γ2
11.11	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
11.11	Single	8IHI	Acifran	8IHI-HCA₂-Acifran-Gi1/β1/γ2
11.11	Single	8JIL	Niacin	8JIL-HCA₂-Niacin-Gi1/β1/γ2
11.11	Single	8JLO	Ulotaront	8JLO-TA1-Ulotaront-Gs/β1/γ2
11.11	Single	8K5B	Niacin	8K5B-HCA₂-Niacin
11.11	Single	8UO3	Constrained Epinephrine	8UO3-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
11.11	Single	8W89	PEA	8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
11.11	Single	8YN4	Histamine	8YN4-H₂-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11	Single	9IQT	Niacin	9IQT-HCA₂-Niacin-Gi1/β1/γ2
11.11	Consensus	h1_on	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.81	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
10.71	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
10.71	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
10.71	Single	9B54	A1AIW	9B54-CB₁-A1AIW-Gi1/β1/γ2
10.53	Single	2Z73	11-cis-Retinal	2Z73-Rhodopsin-11-cis-Retinal
10.53	Single	3AYN	9-cis-Retinal	3AYN-Rhodopsin-9-cis-Retinal
10.53	Single	4K5Y	CP-376395	4K5Y-CRF₁-CP-376395
10.53	Single	4S0V	Suvorexant	4S0V-OX₂-Suvorexant
10.53	Single	6B73	MP1104	6B73-κ-MP1104
10.53	Single	6KUY	PubChem 145704643	6KUY-α_2a-PubChem 145704643
10.53	Single	6TOD	EMPA	6TOD-OX₁-EMPA-Na
10.53	Single	6TPJ	Suvorexant	6TPJ-OX₂-Suvorexant
10.53	Single	7DHR	Isoprenaline	7DHR-β₂-Isoprenaline-Gs/β1/γ2
10.53	Single	7LD4	Adenosine	7LD4-A₁-Adenosine-Gi2/β1/γ2
10.53	Single	7LJD	Dopamine	7LJD-D₁-Dopamine-Mevidalen-Gs/β1/γ1
10.53	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
10.53	Single	7YM8	Oxymetazoline	7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
10.53	Single	7YMH	Norepinephrine	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
10.53	Single	8EFO	PZM21	8EFO-μ-PZM21-Gi1/β1/γ2
10.53	Single	8FYX	Buspirone	8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1
10.53	Single	8GGA	Constrained Epinephrine	8GGA-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53	Single	8GGC	Constrained Epinephrine	8GGC-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53	Single	8GGR	Constrained Epinephrine	8GGR-β₂-Constrained Epinephrine
10.53	Single	8GGW	Constrained Epinephrine	8GGW-β₂-Constrained Epinephrine
10.53	Single	8GGZ	Constrained Epinephrine	8GGZ-β₂-Constrained Epinephrine
10.53	Single	8GH0	Constrained Epinephrine	8GH0-β₂-Constrained Epinephrine
10.53	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/β1/γ2
10.53	Single	8IJA	Niacin	8IJA-HCA₂-Niacin-Gi1/β1/γ2
10.53	Single	8IJB	Acipimox	8IJB-HCA₂-Acipimox-Gi1/β1/γ2
10.53	Single	8J6L	Niacin	8J6L-HCA₂-Niacin-Gi1/β1/γ2
10.53	Single	8TZQ	L-Dopamine	8TZQ-D₂-L-Dopamine-Go/β1/γ2
10.53	Single	8UNX	Constrained Epinephrine	8UNX-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53	Single	8UTD	MK1903	8UTD-HCA₂-MK1903-Gi1/β1/γ2
10.53	Single	8WC3	SEP-363856	8WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
10.53	Single	8WC4	ZH8651	8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
10.53	Single	8WCA	2-Phenylethylamine	8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
10.53	Single	8XQT	Cholesterol	8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
10.53	Single	9MQJ	Isoquinuclidine	9MQJ-μ-Isoquinuclidine
10.53	Consensus	5ht1e_on	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
10.53	Consensus	a1_on	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
10.53	Consensus	a1_on_gp	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
10.53	Consensus	alpha2_off	Orthosteric Ligand	alpha2c_off
10.53	Consensus	gq_histamine	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.53	Consensus	h1_on_gp	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.34	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
10.34	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
10.34	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
10.34	Single	8WST	Pro-MCH	8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.26	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/β1/γ2
10.00	Single	4DKL	Beta-Funaltrexamine	4DKL-μ-β-Funaltrexamine
10.00	Single	4LDO	L-Epinephrine	4LDO-β₂-L-Epinephrine
10.00	Single	4N6H	Naltrindole	4N6H-δ-Naltrindole-Na
10.00	Single	4ZJC	SB-674042	4ZJC-OX₁-SB-674042
10.00	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
10.00	Single	6K41	Dexmedetomidine	6K41-α_2b-Dexmedetomidine-Go/β1/γ2
10.00	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
10.00	Single	6PS0	S-Carazolol	6PS0-β₂-S-Carazolol
10.00	Single	6PS4	ICI118-551	6PS4-β₂-ICI118-551
10.00	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
10.00	Single	6TOS	GSK1059865	6TOS-OX₁-GSK1059865-Na
10.00	Single	6TP3	Nemorexant	6TP3-OX₁-Nemorexant
10.00	Single	6TPG	EMPA	6TPG-OX₂-EMPA
10.00	Single	6VI4	JDTic	6VI4-κ-JDTic
10.00	Single	6WH4	Methiothepin	6WH4-5-HT_2A-Methiothepin
10.00	Single	6WJC	Atropine	6WJC-M₁-Atropine-Muscarinic toxin 7
10.00	Single	6ZFZ	77-LH-28-1	6ZFZ-M₁-77-LH-28-1
10.00	Single	6ZG9	GSK1034702	6ZG9-M₁-GSK1034702
10.00	Single	7BB6	AVP	7BB6-V₂-AVP-Gs/β1/γ2
10.00	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/β1/γ2
10.00	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/β1/γ2
10.00	Single	7CMU	Pramipexole	7CMU-D₃-Pramipexole-Gi1/β1/γ2
10.00	Single	7DHI	Salbutamol	7DHI-β₂-Salbutamol-Gs/β1/γ2
10.00	Single	7E33	BRL-54443	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2
10.00	Single	7EJA	Dexmedetomidine	7EJA-α_2a-Dexmedetomidine-Go/β1/γ2
10.00	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/β1/γ2
10.00	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/β1/γ2
10.00	Single	7F24	Dopamine	7F24-D₁-Dopamine-GDP-Gs/β1/γ2
10.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.00	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-α-factor mating pheromone
10.00	Single	7RAN	PubChem 164575847	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
10.00	Single	7UM7	Methylergometrine	7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
10.00	Single	7VUG	JNJ-63533054	7VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
10.00	Single	8GE1	Constrained Epinephrine	8GE1-β₂-Constrained Epinephrine-Gs/β1/γ2
10.00	Single	8GE4	Constrained Epinephrine	8GE4-β₂-Constrained Epinephrine-Gs/β1/γ2
10.00	Single	8GE6	Constrained Epinephrine	8GE6-β₂-Constrained Epinephrine-Gs/β1/γ2
10.00	Single	8GE7	Constrained Epinephrine	8GE7-β₂-Constrained Epinephrine-Gs/β1/γ2
10.00	Single	8GE8	Constrained Epinephrine	8GE8-β₂-Constrained Epinephrine-Gs/β1/γ2
10.00	Single	8GEA	Constrained Epinephrine	8GEA-β₂-Constrained Epinephrine-Gs/β1/γ2
10.00	Single	8GED	Constrained Epinephrine	8GED-β₂-Constrained Epinephrine-Gs/β1/γ2
10.00	Single	8GEF	Constrained Epinephrine	8GEF-β₂-Constrained Epinephrine-Gs/β1/γ2
10.00	Single	8GG5	Constrained Epinephrine	8GG5-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00	Single	8GG8	Constrained Epinephrine	8GG8-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00	Single	8GGQ	Constrained Epinephrine	8GGQ-β₂-Constrained Epinephrine
10.00	Single	8GGS	Constrained Epinephrine	8GGS-β₂-Constrained Epinephrine
10.00	Single	8GGT	Constrained Epinephrine	8GGT-β₂-Constrained Epinephrine
10.00	Single	8GGV	Constrained Epinephrine	8GGV-β₂-Constrained Epinephrine
10.00	Single	8GGX	Constrained Epinephrine	8GGX-β₂-Constrained Epinephrine
10.00	Single	8IHK	Acifran	8IHK-HCA₃-Acifran
10.00	Single	8IY9	Niacin	8IY9-HCA₂-Niacin-Go/β1/γ2
10.00	Single	8JEI	3-nitro-4-(propylamino)benzoic acid	8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
10.00	Single	8JER	Acipimox	8JER-HCA₂-Acipimox-Go/β1/γ2
10.00	Single	8JIM	MMF	8JIM-HCA₂-MMF-Gi1/β1/γ2
10.00	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
10.00	Single	8JLN	T1AM	8JLN-TA1-T1AM-Gs/β1/γ2
10.00	Single	8K5C	Acipimox	8K5C-HCA₂-Acipimox
10.00	Single	8THK	A61603	8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00	Single	8THL	Epinephrine	8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00	Single	8U02	L-Dopamine	8U02-D₂-L-Dopamine-Go/β1/γ2
10.00	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/β1/γ2
10.00	Single	8UNM	Constrained Epinephrine	8UNM-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00	Single	8UNW	Constrained Epinephrine	8UNW-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00	Single	8UO0	Constrained Epinephrine	8UO0-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00	Single	8W88	SEP-363856	8W88-TA1-SEP-363856-Gs/β1/γ2
10.00	Single	8W8B	SEP-363856	8W8B-5-HT_1A-SEP-363856-Gi1/β1/γ2
10.00	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
10.00	Single	8X7A	Treprostinil	8X7A-I2-Treprostinil-Gs/β1/γ2
10.00	Single	8Y45	ADL5859	8Y45-δ-ADL5859-Gi2/β1/γ2
10.00	Single	8Y53	MK5046	8Y53-BB₃-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Single	8YH2	Adenosine	8YH2-A_3A-Adenosine-Gi1/β1/γ2
10.00	Single	8YN3	Histamine	8YN3-H₂-Histamine-Gs/β1/γ2
10.00	Single	9BJK	Naloxone	9BJK-μ-Naloxone-NAM
10.00	Single	9CBL	Epinephrine	9CBL-α_2a-Epinephrine-Gi1/β1/γ2
10.00	Single	9MQI	Isoquinuclidine	9MQI-μ-Isoquinuclidine
10.00	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on a3_on
10.00	Consensus	alpha1_on	Orthosteric Ligand	alpha1a_on
10.00	Consensus	alpha1_on_gp	Orthosteric Ligand	alpha1a_on_gp
10.00	Consensus	alpha1a_on	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2
10.00	Consensus	alpha1a_on_gp	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2
10.00	Consensus	d3_on	Orthosteric Ligand	7CMV-D₃-PD128907-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2
10.00	Consensus	d3_on_gp	Orthosteric Ligand	7CMV-D₃-PD128907-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2
10.00	Consensus	gi_adenosine	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2 8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
10.00	Consensus	hca_on	Orthosteric Ligand	hca2_on
10.00	Consensus	nop_off	Orthosteric Ligand	4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
9.68	Single	6FJ3	PTH	6FJ3-PTH1-PTH
9.68	Single	6NBF	Long-Acting PTH Analog	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
9.68	Single	6NBI	Long-Acting PTH Analog	6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
9.68	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-α-factor mating pheromone
9.68	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
9.52	Single	2Y04	Salbutamol	2Y04-β₁-Salbutamol
9.52	Single	3NY8	ICI118-551	3NY8-β₂-ICI118-551
9.52	Single	3NYA	S-Alprenolol	3NYA-β₂-S-Alprenolol
9.52	Single	4EA3	PubChem 10296561	4EA3-NOP-PubChem 10296561
9.52	Single	4EJ4	Naltrindole	4EJ4-δ-Naltrindole
9.52	Single	4GBR	S-Carazolol	4GBR-β₂-S-Carazolol
9.52	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
9.52	Single	4MQS	Iperoxo	4MQS-M₂-Iperoxo
9.52	Single	4QKX	35V	4QKX-β₂-35V
9.52	Single	4U14	Tiotropium	4U14-M₃-Tiotropium
9.52	Single	4X1H	Nonyl-Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
9.52	Single	4Z9G	CP-376395	4Z9G-CRF₁-CP-376395
9.52	Single	5DHG	C-35	5DHG-NOP-C-35
9.52	Single	5DHH	SB-612111	5DHH-NOP-SB-612111
9.52	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
9.52	Single	6DRZ	Methysergide	6DRZ-5-HT_2B-Methysergide
9.52	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
9.52	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
9.52	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
9.52	Single	6H7M	Salbutamol	6H7M-β₁-Salbutamol
9.52	Single	6IIV	Daltroban	6IIV-TP-Daltroban
9.52	Single	6K42	Dexmedetomidine	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
9.52	Single	6PS1	Timolol	6PS1-β₂-Timolol
9.52	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
9.52	Single	7BTS	L-Epinephrine	7BTS-β₁-L-Epinephrine
9.52	Single	7BU6	L-Norepinephrine	7BU6-β₁-L-Norepinephrine
9.52	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/β1/γ2
9.52	Single	7E32	Serotonin	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
9.52	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/β1/γ2
9.52	Single	7LJC	SKF-81297	7LJC-D₁-SKF-81297-Mevidalen-Gs/β1/γ2
9.52	Single	7S0G	Isoprenaline	7S0G-β₁-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
9.52	Single	7SCG	FH210	7SCG-μ-FH210-Gi1/β1/γ2
9.52	Single	7T2G	Mitragynine Pseudoindoxyl	7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
9.52	Single	7TRP	Iperoxo	7TRP-M₄-Iperoxo-LY2033298-Gi1/β1/γ2
9.52	Single	7UL4	Alvimopan	7UL4-μ-Alvimopan
9.52	Single	7VKT	LTB4	7VKT-BLT₁-LTB4-Gi1/β1/γ2
9.52	Single	7WC8	Lumateperone	7WC8-5-HT_2A-Lumateperone
9.52	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/β1/γ2
9.52	Single	7YAC	Paltusotine	7YAC-SST2-Paltusotine-Gi1/β1/γ2
9.52	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
9.52	Single	8FY8	5-MeO-DMT	8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1
9.52	Single	8GE3	Constrained Epinephrine	8GE3-β₂-Constrained Epinephrine-Gs/β1/γ2
9.52	Single	8GE9	Constrained Epinephrine	8GE9-β₂-Constrained Epinephrine-Gs/β1/γ2
9.52	Single	8GEC	Constrained Epinephrine	8GEC-β₂-Constrained Epinephrine-Gs/β1/γ2
9.52	Single	8GEE	Constrained Epinephrine	8GEE-β₂-Constrained Epinephrine-Gs/β1/γ2
9.52	Single	8GEH	Constrained Epinephrine	8GEH-β₂-Constrained Epinephrine-Gs/β1/γ2
9.52	Single	8GFV	Constrained Epinephrine	8GFV-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8GFW	Constrained Epinephrine	8GFW-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8GFX	Constrained Epinephrine	8GFX-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8GFZ	Constrained Epinephrine	8GFZ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8GG0	Constrained Epinephrine	8GG0-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8GG1	Constrained Epinephrine	8GG1-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8GG3	Constrained Epinephrine	8GG3-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8GG4	Constrained Epinephrine	8GG4-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8GG6	Constrained Epinephrine	8GG6-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8GG9	Constrained Epinephrine	8GG9-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8GGI	Constrained Epinephrine	8GGI-β₂-Constrained Epinephrine
9.52	Single	8GGJ	Constrained Epinephrine	8GGJ-β₂-Constrained Epinephrine
9.52	Single	8GGK	Constrained Epinephrine	8GGK-β₂-Constrained Epinephrine
9.52	Single	8GGN	Constrained Epinephrine	8GGN-β₂-Constrained Epinephrine
9.52	Single	8GGO	Constrained Epinephrine	8GGO-β₂-Constrained Epinephrine
9.52	Single	8GGU	Constrained Epinephrine	8GGU-β₂-Constrained Epinephrine
9.52	Single	8GTI	BMK-C205	8GTI-CRF₁-BMK-C205
9.52	Single	8I7V	Acipimox	8I7V-HCA₂-Acipimox-Gi1/β1/γ2
9.52	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/β1/γ2
9.52	Single	8IRT	Rotigotine	8IRT-D₃-Rotigotine-Gi1/β1/γ2
9.52	Single	8J6P	Niacin	8J6P-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
9.52	Single	8JHN	MMF	8JHN-HCA₂-MMF-Go/β1/γ2
9.52	Single	8JII	Niacin	8JII-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
9.52	Single	8JJO	Alprenolol	8JJO-β₂-Alprenolol
9.52	Single	8JLJ	T1AM	8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
9.52	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
9.52	Single	8JXR	LSD	8JXR-D₁-LSD
9.52	Single	8K5D	GSK256073	8K5D-HCA₂-GSK256073
9.52	Single	8PJK	ST171	8PJK-5-HT_1A-ST171-t7m-Gi1/β1/γ1
9.52	Single	8UGY	Mianserin	8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1
9.52	Single	8UNQ	Constrained Epinephrine	8UNQ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8UNR	Constrained Epinephrine	8UNR-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8UNU	Constrained Epinephrine	8UNU-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8UNV	Constrained Epinephrine	8UNV-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8UNY	Constrained Epinephrine	8UNY-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8UNZ	Constrained Epinephrine	8UNZ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8UO2	Constrained Epinephrine	8UO2-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52	Single	8UWL	Lisuride	8UWL-5-HT_2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
9.52	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
9.52	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
9.52	Single	8WC7	ZH8667	8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
9.52	Single	8X17	Namodenoson	8X17-A_3A-Namodenoson-Gi1/β1/γ2
9.52	Single	8X63	Mepyramine	8X63-H₁-Mepyramine
9.52	Single	8XJL	PGF2-alpha	8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
9.52	Single	8XVK	Ambrisentan	8XVK-ET_A-Ambrisentan
9.52	Single	8ZQE	GPR15L(C11)	8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
9.52	Single	8ZSS	RO5263397	8ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
9.52	Single	9CBM	Dexmedetomidine	9CBM-α_2a-Dexmedetomidine-Gi1/β1/γ2
9.52	Single	9D61	JDTic	9D61-κ-JDTic-Gi1/β1/γ2
9.52	Consensus	5ht1d_on	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
9.52	Consensus	5ht1d_on_gp	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
9.52	Consensus	5ht2b_off	Orthosteric Ligand	6DRZ-5-HT_2B-Methysergide
9.52	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
9.52	Consensus	5ht6_on_gp	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
9.52	Consensus	a3_on	Orthosteric Ligand	a3a_on
9.52	Consensus	adenosine_on_gp	Orthosteric Ligand	a1_on_gp a2_on_gp a3_on_gp
9.52	Consensus	adrenergic_on	Orthosteric Ligand	alpha_on beta_on
9.52	Consensus	alicarboxylic_on_gp	Orthosteric Ligand	succinate_on_gp hca_on_gp
9.52	Consensus	alpha2_on	Orthosteric Ligand	alpha2b_on
9.52	Consensus	alpha2_on_gp	Orthosteric Ligand	alpha2b_on_gp
9.52	Consensus	alpha2b_on	Orthosteric Ligand	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
9.52	Consensus	alpha2b_on_gp	Orthosteric Ligand	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
9.52	Consensus	alpha_on	Orthosteric Ligand	alpha1_on alpha2_on
9.52	Consensus	blt1_on	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
9.52	Consensus	blt1_on_gp	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
9.52	Consensus	blt_on	Orthosteric Ligand	blt1_on
9.52	Consensus	blt_on_gp	Orthosteric Ligand	blt1_on_gp
9.52	Consensus	d5_on	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
9.52	Consensus	dop_off	Orthosteric Ligand	4EJ4-δ-Naltrindole
9.52	Consensus	dopamine_off	Orthosteric Ligand	d2_off d3_off
9.52	Consensus	dopamine_on	Orthosteric Ligand	d2_on d1_on d3_on d4_on d5_on
9.52	Consensus	dopamine_on_gp	Orthosteric Ligand	d2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
9.52	Consensus	gi_alicarboxylic	Orthosteric Ligand	gi_hca gi_succinate
9.52	Consensus	gi_hca	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
9.52	Consensus	gi_leukotriene	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
9.52	Consensus	gq_amine	Orthosteric Ligand	gq_muscarinic gq_histamine
9.52	Consensus	gs_trace-amine	Orthosteric Ligand	8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
9.52	Consensus	hca2_on	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2
9.52	Consensus	hca2_on_gp	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
9.52	Consensus	hca_on_gp	Orthosteric Ligand	hca2_on_gp
9.52	Consensus	histamine_off	Orthosteric Ligand	h1_off
9.52	Consensus	leukotriene_on	Orthosteric Ligand	blt_on
9.52	Consensus	leukotriene_on_gp	Orthosteric Ligand	blt_on_gp
9.38	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
9.38	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
9.38	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/β1/γ2
9.38	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-α-factor mating pheromone
9.38	Single	8FEG	(DNCP)-Beta-Naloxamine	8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
9.09	Single	2RH1	S-Carazolol	2RH1-β₂-S-Carazolol
9.09	Single	2Y03	Isoprenaline	2Y03-β₁-Isoprenaline
9.09	Single	2YCW	S-Carazolol	2YCW-β₁-S-Carazolol
9.09	Single	5C1M	BU72	5C1M-μ-BU72
9.09	Single	5D6L	S-Carazolol	5D6L-β₂-S-Carazolol
9.09	Single	5TVN	LSD	5TVN-5-HT_2B-LSD
9.09	Single	5WIU	Nemonapride	5WIU-D₄-Nemonapride
9.09	Single	5WIV	Nemonapride	5WIV-D₄-Nemonapride-Na
9.09	Single	5WQC	EMPA	5WQC-OX₂-EMPA
9.09	Single	5X7D	S-Carazolol	5X7D-β₂-S-Carazolol-PubChem 129318963
9.09	Single	6KUW	PubChem 57213234	6KUW-α_2c-PubChem 57213234
9.09	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
9.09	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
9.09	Single	6NBH	Long-Acting PTH Analog	6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
9.09	Single	6PS3	S-Carvedilol	6PS3-β₂-S-Carvedilol
9.09	Single	7BVQ	S-Carazolol	7BVQ-β₁-S-Carazolol
9.09	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
9.09	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-α-factor mating pheromone
9.09	Single	7S0F	Isoprenaline	7S0F-β₁-Isoprenaline-Gi1/β1/γ2
9.09	Single	7SBF	PZM21	7SBF-μ-PZM21-Gi1/β1/γ2
9.09	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
9.09	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
9.09	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
9.09	Single	7VOE	Aripiprazole	7VOE-5-HT_2A-Aripiprazole
9.09	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
9.09	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
9.09	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/β1/γ2
9.09	Single	7WC6	LSD	7WC6-5-HT_2A-LSD
9.09	Single	7WIG	L-054,264	7WIG-SST2-L-054,264-Gi1/β1/γ2
9.09	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09	Single	7XK9	Constrained Isoproterenol	7XK9-β₂-Constrained Isoproterenol-Na
9.09	Single	7XKA	Constrained Epinephrine	7XKA-β₂-Constrained Epinephrine
9.09	Single	8DZQ	momSalB	8DZQ-κ-momSalB-Go/β1/γ2
9.09	Single	8DZR	GR89,696	8DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
9.09	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/β1/γ2
9.09	Single	8GDZ	Constrained Epinephrine	8GDZ-β₂-Constrained Epinephrine-Gs/β1/γ2
9.09	Single	8GEB	Constrained Epinephrine	8GEB-β₂-Constrained Epinephrine-Gs/β1/γ2
9.09	Single	8GEG	Constrained Epinephrine	8GEG-β₂-Constrained Epinephrine-Gs/β1/γ2
9.09	Single	8GFY	Constrained Epinephrine	8GFY-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09	Single	8GG2	Constrained Epinephrine	8GG2-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09	Single	8GGB	Constrained Epinephrine	8GGB-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09	Single	8GTG	BMK-I152	8GTG-CRF₁-BMK-I152
9.09	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
9.09	Single	8HNL	PS372424	8HNL-CXCR3-PS372424-Gi1/β1/γ2
9.09	Single	8I7W	GSK256073	8I7W-HCA₂-GSK256073-Gi1/β1/γ2
9.09	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/β1/γ2
9.09	Single	8TF5	Oleic acid	8TF5-GPR6-Oleic acid
9.09	Single	8UNN	Constrained Epinephrine	8UNN-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09	Single	8UNP	Constrained Epinephrine	8UNP-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09	Single	8UUJ	FCH-2296413	8UUJ-HCA₂-FCH-2296413-Gi1/β1/γ2
9.09	Single	8VVE	norBNI	8VVE-κ-norBNI-Gi1/β1/γ2
9.09	Single	8XYK	VUF10661	8XYK-CXCR3-VUF10661-Go1/β1/γ2
9.09	Single	8YH0	NECA	8YH0-A_3A-NECA-Gi1/β1/γ2
9.09	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
9.09	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
9.09	Single	9F34	FOB02-04A	9F34-D₃-FOB02-04A-Go1/β1/γ2
9.09	Single	9MQK	Isoquinuclidine	9MQK-κ-Isoquinuclidine
9.09	Consensus	5ht1_on	Orthosteric Ligand	5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
9.09	Consensus	5ht1_on_gp	Orthosteric Ligand	5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
9.09	Consensus	5ht1e_on_gp	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
9.09	Consensus	5ht2_off	Orthosteric Ligand	5ht2a_off 5ht2b_off 5ht2c_off
9.09	Consensus	5ht5_on_gp	Orthosteric Ligand	5ht5a_on_gp
9.09	Consensus	5ht5a_on_gp	Orthosteric Ligand	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
9.09	Consensus	a3_on_gp	Orthosteric Ligand	a3a_on_gp
9.09	Consensus	a3a_on	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
9.09	Consensus	a3a_on_gp	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
9.09	Consensus	adrenergic_off	Orthosteric Ligand	alpha_off beta_off
9.09	Consensus	adrenergic_on_gp	Orthosteric Ligand	alpha_on_gp beta_on_gp
9.09	Consensus	alpha2c_off	Orthosteric Ligand	6KUW-α_2c-PubChem 57213234
9.09	Consensus	alpha_off	Orthosteric Ligand	alpha1_off alpha2_off
9.09	Consensus	alpha_on_gp	Orthosteric Ligand	alpha1_on_gp alpha2_on_gp
9.09	Consensus	amine_off	Orthosteric Ligand	5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
9.09	Consensus	amine_offon	Orthosteric Ligand	amine_off amine_on
9.09	Consensus	amine_offon_gp	Orthosteric Ligand	amine_on_gp amine_off
9.09	Consensus	amine_on	Orthosteric Ligand	5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
9.09	Consensus	beta2_off	Orthosteric Ligand	2RH1-β₂-S-Carazolol 6PS3-β₂-S-Carvedilol 6PS5-β₂-S-Propranolol 3D4S-β₂-Timolol 3NY8-β₂-ICI118-551 3NY9-β₂-ICI118-551 6PRZ-β₂-S-Alprenolol
9.09	Consensus	beta_off	Orthosteric Ligand	beta1_off beta2_off
9.09	Consensus	d2_on	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2
9.09	Consensus	d4_on	Orthosteric Ligand	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
9.09	Consensus	gi_adrenergic	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
9.09	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
9.09	Consensus	h1_off	Orthosteric Ligand	8X63-H₁-Mepyramine 3RZE-H₁-Cidoxepin 8X5Y-H₁-Astemizole
9.09	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09	Consensus	trace-amine_on	Orthosteric Ligand	ta1_on
8.82	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2
8.82	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
8.70	Single	4DJH	JDTic	4DJH-κ-JDTic
8.70	Single	4LDL	Hydroxybenzylisoproterenol	4LDL-β₂-Hydroxybenzylisoproterenol
8.70	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
8.70	Single	5D5A	S-Carazolol	5D5A-β₂-S-Carazolol
8.70	Single	5D5B	S-Carazolol	5D5B-β₂-S-Carazolol
8.70	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
8.70	Single	6H7J	Isoprenaline	6H7J-β₁-Isoprenaline
8.70	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
8.70	Single	6KO5	PubChem 57400002	6KO5-Ghrelin-PubChem 57400002
8.70	Single	6N48	BI167107	6N48-β₂-BI167107-PubChem 138454256
8.70	Single	6NI3	BI167107	6NI3-β₂-BI167107-Gs/β1/γ2
8.70	Single	6TQ7	SB-334867	6TQ7-OX₁-SB-334867
8.70	Single	6WGT	LSD	6WGT-5-HT_2A-LSD
8.70	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/β1/γ2
8.70	Single	7E2Z	Aripiprazole	7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2
8.70	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
8.70	Single	7EW7	SEW2871	7EW7-S1P₁-SEW2871-Gi1/β1/γ2
8.70	Single	7JJO	Isoprenaline	7JJO-β₁-Isoprenaline-Gs/β1/γ2
8.70	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/β1/γ2
8.70	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
8.70	Single	7W6P	N-pyridin-4-ylisoquinolin-4-amine	7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
8.70	Single	7W7E	PubChem 164946676	7W7E-α_2a-PubChem 164946676-Go/β1/γ2
8.70	Single	7WV9	CP55940	7WV9-CB₁-CP55940-ZCZ011-Gi2/β1/γ2
8.70	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/β1/γ2
8.70	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/β1/γ2
8.70	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/β1/γ2
8.70	Single	8E0G	BU72	8E0G-μ-BU72
8.70	Single	8EFL	SR17018	8EFL-μ-SR17018-Gi1/β1/γ2
8.70	Single	8GDB	PGE2	8GDB-EP₄-PGE2-Gs/β1/γ2
8.70	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
8.70	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/β1/γ2
8.70	Single	8IHH	LUF6283	8IHH-HCA₂-LUF6283-Gi1/β1/γ2
8.70	Single	8IRR	Rotigotine	8IRR-D₁-Rotigotine-Gs/β1/γ2
8.70	Single	8IRV	Rotigotine	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
8.70	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/β1/γ2
8.70	Single	8J20	AR420626	8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
8.70	Single	8JT6	(R)-IHCH-7179	8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2
8.70	Single	8UGW	PubChem 3086599	8UGW-A_2A-PubChem 3086599
8.70	Single	8VVF	JDTic	8VVF-κ-JDTic-Gi1/β1/γ2
8.70	Single	8X16	Piclidenoson	8X16-A_3A-Piclidenoson-Gi1/β1/γ2
8.70	Single	8XIP	Pasireotide	8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.70	Single	8XZI	CMF-019	8XZI-Apelin-CMF-019-Gi1/β1/γ2
8.70	Single	8YH6	Namodenoson	8YH6-A_3A-Namodenoson-Gi1/β1/γ2
8.70	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
8.70	Single	9F33	FOB02-04A	9F33-D₃-FOB02-04A-Go1/β1/γ2
8.70	Single	9IJD	Carazolol	9IJD-β₃-Carazolol-chim(NtGi1-Gs)/β1/γ2
8.70	Consensus	a2_on	Orthosteric Ligand	a2b_on
8.70	Consensus	a2_on_gp	Orthosteric Ligand	a2b_on_gp
8.70	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
8.70	Consensus	a2b_on_gp	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
8.70	Consensus	amine_on_gp	Orthosteric Ligand	5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
8.70	Consensus	beta1_off	Orthosteric Ligand	2VT4-β₁-Cyanopindolol 2YCW-β₁-S-Carazolol 2YCZ-β₁-Iodocyanopindolol 5A8E-β₁-7-Methylcyanopindolol-Na 3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
8.70	Consensus	beta2_on	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2
8.70	Consensus	beta2_on_gp	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2
8.70	Consensus	d1_on_gp	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
8.70	Consensus	d5_on_gp	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
8.70	Consensus	gi_5ht	Orthosteric Ligand	8FYT-5-HT_1A-LSD-Gi1/β1/γ1 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT_1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2 7E32-5-HT_1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT₄-Serotonin-Gi1/β1/γ2 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2
8.70	Consensus	gi_dopamine	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 7CMV-D₃-PD128907-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2
8.70	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
8.70	Consensus	gs_adrenergic	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2 7JJO-β₁-Isoprenaline-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2 8DCR-β₁-Dobutamine-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7DH5-β₃-Mirabegron-Gs/β1/γ2
8.70	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2
8.70	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
8.70	Consensus	kop_off	Orthosteric Ligand	4DJH-κ-JDTic
8.70	Consensus	protein_off	Orthosteric Ligand	chemokine_off grh_off
8.70	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
8.70	Consensus	s1p5_on_gp	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
8.70	Consensus	ta1_on_gp	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.70	Consensus	trace-amine_on_gp	Orthosteric Ligand	ta1_on_gp
8.57	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/β1/γ1
8.57	Single	8F2A	Pramlintide Analogue San385	8F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
8.33	Single	3D4S	Timolol	3D4S-β₂-Timolol
8.33	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
8.33	Single	4LDE	BI167107	4LDE-β₂-BI167107
8.33	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
8.33	Single	6AK3	Dinoprostone IPGE2	6AK3-EP₃-Dinoprostone IPGE2
8.33	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
8.33	Single	6DRY	Methylergonovine	6DRY-5-HT_2B-Methylergonovine
8.33	Single	6H7N	S-Xamoterol	6H7N-β₁-S-Xamoterol
8.33	Single	6H7O	Cyanopindolol	6H7O-β₁-Cyanopindolol
8.33	Single	6IIU	Ramatroban	6IIU-TP-Ramatroban
8.33	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/β1/γ2
8.33	Single	6ZG4	HTL0009936	6ZG4-M₁-HTL0009936
8.33	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/β1/γ2
8.33	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/β1/γ2
8.33	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/β1/γ2
8.33	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
8.33	Single	7JNI	Olodanrigan	7JNI-AT₂-Olodanrigan
8.33	Single	7K15	MKD046	7K15-BLT₁-MKD046-Na
8.33	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
8.33	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/β1/γ2
8.33	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
8.33	Single	7YMJ	Tamsulosin	7YMJ-Alpha1A-Tamsulosin
8.33	Single	8FYT	LSD	8FYT-5-HT_1A-LSD-Gi1/β1/γ1
8.33	Single	8IQ6	Latanoprost	8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/β1/γ2
8.33	Single	8IYW	GSK256073	8IYW-HCA₂-GSK256073-Go/β1/γ2
8.33	Single	8JJ8	Formoterol	8JJ8-β₂-Formoterol
8.33	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/β1/γ2
8.33	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
8.33	Single	8XQN	Cholesterol	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
8.33	Single	8XYI	VUF10661	8XYI-CXCR3-VUF10661
8.33	Single	9JR2	PTH	9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33	Single	9MQL	Isoquinuclidine	9MQL-κ-Isoquinuclidine
8.33	Consensus	5ht1a_on	Orthosteric Ligand	8FYT-5-HT_1A-LSD-Gi1/β1/γ1 7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
8.33	Consensus	5ht1a_on_gp	Orthosteric Ligand	8FYT-5-HT_1A-LSD-Gi1/β1/γ1 8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
8.33	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
8.33	Consensus	5ht1f_on_gp	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
8.33	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off
8.33	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin
8.33	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
8.33	Consensus	beta3_on_gp	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
8.33	Consensus	beta_on	Orthosteric Ligand	beta1_on beta2_on beta3_on
8.33	Consensus	beta_on_gp	Orthosteric Ligand	beta1_on_gp beta2_on_gp beta3_on_gp
8.33	Consensus	cannabinoid_off	Orthosteric Ligand	cb2_off cb1_off
8.33	Consensus	d2_on_gp	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2
8.33	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
8.33	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
8.33	Consensus	m4_on_gp	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
8.33	Consensus	mop_on	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
8.33	Consensus	mop_on_gp	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
8.33	Consensus	nk1_off	Orthosteric Ligand	6HLP-NK₁-Netupitant 6HLO-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
8.33	Consensus	opioid_off	Orthosteric Ligand	mop_off nop_off dop_off kop_off
8.33	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33	Consensus	trh_on_gp	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.11	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/β1/γ2
8.00	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
8.00	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
8.00	Single	5UNG	PubChem 15780052	5UNG-AT₂-PubChem 15780052
8.00	Single	5X93	K-8794	5X93-ET_B-K-8794
8.00	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
8.00	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
8.00	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
8.00	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/β1/γ2
8.00	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2
8.00	Single	7EZC	UKA	7EZC-A_2A-UKA
8.00	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2
8.00	Single	7SK8	CCX662	7SK8-ACKR3-CXCL12-CCX662
8.00	Single	7UM4	AS2674723	7UM4-5-HT_5A-AS2674723
8.00	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/β1/γ2
8.00	Single	7XK2	MK6892	7XK2-HCA₂-MK6892-Gi1/β1/γ2
8.00	Single	8ID8	TUG-891	8ID8-FFA4-TUG-891-Gi1/β1/γ2
8.00	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/β1/γ2
8.00	Single	8XGS	Metastin	8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
8.00	Single	8XIO	L797591	8XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.00	Single	9IZF	NKP	9IZF-LPA₁-NKP-Gi1/β1/γ2
8.00	Consensus	beta1_on	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
8.00	Consensus	beta1_on_gp	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
8.00	Consensus	class-a_on	Orthosteric Ligand	sensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
8.00	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
8.00	Consensus	endothelin_off	Orthosteric Ligand	etb_off
8.00	Consensus	etb_off	Orthosteric Ligand	5X93-ET_B-K-8794 5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500
8.00	Consensus	kop_on_gp	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
8.00	Consensus	nucleotide_on_gp	Orthosteric Ligand	adenosine_on_gp p2y_on_gp
7.69	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
7.69	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
7.69	Single	7T11	Octreotide	7T11-SST2-Octreotide-Gi3/β1/γ2
7.69	Single	7XN9	L-054,522	7XN9-SST2-L-054,522
7.69	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/β1/γ2
7.69	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/β1/γ2
7.69	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
7.69	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
7.69	Single	8X3L	XWD	8X3L-CB₂-XWD-Gi1/β1/γ2
7.69	Single	8XQL	Cholesterol	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
7.69	Single	8XQO	Cholesterol	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
7.69	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
7.69	Consensus	cxcr3_on	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
7.69	Consensus	s1p_on	Orthosteric Ligand	s1p1_on s1p3_on s1p5_on
7.69	Consensus	s1p_on_gp	Orthosteric Ligand	s1p1_on_gp s1p3_on_gp s1p5_on_gp
7.69	Consensus	sst2_on	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
7.69	Consensus	sst2_on_gp	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
7.41	Single	4AMJ	S-Carvedilol	4AMJ-β₁-S-Carvedilol
7.41	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
7.41	Single	5UNF	PubChem 15780052	5UNF-AT₂-PubChem 15780052
7.41	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
7.41	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/β1/γ2
7.41	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/β1/γ2
7.41	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2
7.41	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
7.41	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/β1/γ2
7.41	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/β1/γ2
7.41	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/β1/γ2
7.41	Single	8FYL	Vilazodone	8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
7.41	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/β1/γ2
7.41	Single	8PKM	Befiradol	8PKM-5-HT_1A-Befiradol-t7m-Gi1/β1/γ1
7.41	Single	8ZCJ	Pasireotide	8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
7.41	Single	8ZSP	LSD	8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.41	Consensus	class-a_on_gp	Orthosteric Ligand	sensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
7.41	Consensus	gi_nucleotide	Orthosteric Ligand	gi_adenosine gi_p2y
7.41	Consensus	gi_opioid	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
7.41	Consensus	mop_off	Orthosteric Ligand	4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
7.41	Consensus	sst5_on	Orthosteric Ligand	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
7.14	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
7.14	Single	6DO1	Angiotensin-like peptide S1I8	6DO1-AT₁-Angiotensin-like peptide S1I8
7.14	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
7.14	Single	7DDZ	JNJ-31020028	7DDZ-Y₂-JNJ-31020028
7.14	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/β1/γ2
7.14	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
7.14	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2
7.14	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/β1/γ2
7.14	Single	8SG1	Chemerin-9	8SG1-CML1-Chemerin-9-Gi1/β1/γ2
7.14	Consensus	formylpeptide_on_gp	Orthosteric Ligand	fpr2-alx_on_gp fpr1-alx_on_gp
7.14	Consensus	gq_class-a	Orthosteric Ligand	gq_peptide gq_amine gq_nucleotide
7.14	Consensus	npy2_off	Orthosteric Ligand	7DDZ-Y₂-JNJ-31020028
7.14	Consensus	sst4_on	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
7.14	Consensus	sst4_on_gp	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
6.90	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
6.90	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
6.90	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/β1/γ2
6.90	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/β1/γ2
6.90	Single	8XGU	TAK448	8XGU-Kiss1-TAK448-Gi1/β1/γ2
6.90	Single	8XIQ	L796778	8XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
6.90	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
6.90	Consensus	gi_somatostatin	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
6.90	Consensus	somatostatin_on	Orthosteric Ligand	sst2_on sst4_on sst5_on
6.90	Consensus	somatostatin_on_gp	Orthosteric Ligand	sst2_on_gp sst4_on_gp sst5_on_gp
6.67	Single	4A4M	All-trans-Retinal	4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
6.67	Single	5EN0	All-trans-Retinal	5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
6.67	Single	6NIY	Adrenomedullin	6NIY-CT-Adrenomedullin-Gs/β1/γ2
6.67	Single	7KH0	AVP	7KH0-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
6.67	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Single	8GEJ	Constrained Epinephrine	8GEJ-β₂-Constrained Epinephrine-Gs/β1/γ2
6.67	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/β1/γ2
6.67	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/β1/γ2
6.67	Single	8X8L	Cortistatin	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
6.67	Single	8YW5	Retatrutide	8YW5-Glucagon-Retatrutide-Gs/β1/γ2
6.67	Single	9BKK	Cholecystokinin-8	9BKK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Consensus	cxcr3_on_gp	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
6.67	Consensus	fpr2-alx_on_gp	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
6.67	Consensus	gi_class-a	Orthosteric Ligand	gi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
6.67	Consensus	gi_formylpeptide	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
6.45	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/β1/γ2
6.45	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/β1/γ2
6.45	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
6.45	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
6.45	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/β1/γ2
6.45	Single	8WWK	MCH	8WWK-MCH1-MCH-Gi1/β1/γ2
6.45	Single	8WWM	MCH	8WWM-MCH1-MCH-Gi1/β1/γ2
6.45	Single	8XGO	TAK448	8XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
6.45	Consensus	cml1_on_gp	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
6.45	Consensus	opioid_on	Orthosteric Ligand	mop_on nop_on dop_on kop_on
6.45	Consensus	sst5_on_gp	Orthosteric Ligand	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
6.25	Single	3PXO	All-trans-Retinal	3PXO-Rhodopsin-All-trans-Retinal
6.25	Single	5DYS	All-trans-Retinal	5DYS-Rhodopsin-All-trans-Retinal
6.25	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/β1/γ2
6.25	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/β1/γ2
6.25	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
6.25	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/β1/γ2
6.25	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
6.25	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/β1/γ2
6.25	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
6.25	Single	8X9S	5alpha-DHT	8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
6.25	Single	9IV2	5alpha-DHT	9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
6.25	Consensus	opioid_on_gp	Orthosteric Ligand	mop_on_gp nop_on_gp dop_on_gp kop_on_gp
6.06	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/β1/γ2
6.06	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/β1/γ2
6.06	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
6.06	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/β1/γ2
6.06	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
6.06	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/β1/γ2
6.06	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
6.06	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/β1/γ2
6.06	Single	8WWL	MCH	8WWL-MCH1-MCH-Gi1/β1/γ2
6.06	Single	8ZH8	QRF-Amide	8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
6.06	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
5.88	Single	2HPY	All-trans-Retinal	2HPY-Rhodopsin-All-trans-Retinal
5.88	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/β1/γ2
5.88	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/β1/γ2
5.88	Single	6LML	Glucagon	6LML-Glucagon-Glucagon-Gi1/β1/γ1
5.88	Single	6OT0	25(S)-Epoxycholesterol	6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
5.88	Single	6OY9	All-trans-Retinal	6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.88	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/β1/γ2
5.88	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.88	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
5.88	Single	7MTB	All-trans-Retinal	7MTB-Rhodopsin-All-trans-Retinal-GRK1
5.88	Single	8WWN	MCH	8WWN-MCH1-MCH-Gi1/β1/γ2
5.88	Single	8ZPN	Cholesterol	8ZPN-CXCR4-AMD3100-Cholesterol
5.88	Single	9C2F	Ca; Ca; Tryptophan; '6218; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.88	Single	9CHU	Noradrenaline	9CHU-β₂-Noradrenaline
5.88	Consensus	bk2_on	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
5.88	Consensus	bk2_on_gp	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
5.88	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on
5.88	Consensus	bradykinin_on_gp	Orthosteric Ligand	bk2_on_gp
5.88	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
5.88	Consensus	gs_histamine	Orthosteric Ligand	8POK-H₂-Histamine-Gs/β1/γ2
5.88	Consensus	h2_on	Orthosteric Ligand	8POK-H₂-Histamine-Gs/β1/γ2
5.88	Consensus	opsins_on	Orthosteric Ligand	rhodopsin_on opsin1lw_on
5.88	Consensus	sensory_on	Orthosteric Ligand	opsins_on
5.71	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
5.71	Consensus	bb2_on_gp	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
5.71	Consensus	bombesin_on	Orthosteric Ligand	bb2_on
5.71	Consensus	bombesin_on_gp	Orthosteric Ligand	bb2_on_gp
5.71	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
5.56	Single	2J4Y	11-cis-Retinal	2J4Y-Rhodopsin-11-cis-Retinal
5.56	Single	2ZIY	11-cis-Retinal	2ZIY-Rhodopsin-11-cis-Retinal
5.56	Single	3C9M	11-cis-Retinal	3C9M-Rhodopsin-11-cis-Retinal
5.56	Single	3PQR	All-trans-Retinal	3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
5.56	Single	3UZA	GTPL9236	3UZA-A_2A-GTPL9236
5.56	Single	6FK9	PubChem 132473036	6FK9-Rhodopsin-PubChem 132473036
5.56	Single	6FUF	All-trans-Retinal	6FUF-Rhodopsin-All-trans-Retinal-Go
5.56	Single	7D77	Hydrocortisone	7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
5.56	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.56	Single	7MT8	All-trans-Retinal	7MT8-Rhodopsin-All-trans-Retinal-GRK1
5.56	Single	7MT9	All-trans-Retinal	7MT9-Rhodopsin-All-trans-Retinal-GRK1
5.56	Single	7MTA	All-trans-Retinal	7MTA-Rhodopsin-All-trans-Retinal-GRK1
5.56	Single	8F76	Propanoic acid	8F76-OR51E2-Propanoic acid-Gs/β1/γ2
5.56	Single	8GGE	Constrained Epinephrine	8GGE-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8GH1	Constrained Epinephrine	8GH1-β₂-Constrained Epinephrine
5.56	Single	8IU2	Retinal	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.56	Single	8JEF	(3S)-3-hydroxyoctanoic acid	8JEF-HCA₃-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
5.56	Single	8POK	Histamine	8POK-H₂-Histamine-Gs/β1/γ2
5.56	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.56	Single	8ZPL	Cholesterol	8ZPL-CXCR4-HF51116-Cholesterol
5.56	Single	8ZPM	Cholesterol	8ZPM-CXCR4-AMD070-Cholesterol
5.56	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.56	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.56	Single	9IV1	5alpha-DHT	9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
5.56	Consensus	5ht2_on	Orthosteric Ligand	5ht2b_on
5.56	Consensus	5ht2b_on	Orthosteric Ligand	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56	Consensus	gi_opsins	Orthosteric Ligand	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.56	Consensus	gi_sensory	Orthosteric Ligand	gi_opsins
5.56	Consensus	h2_on_gp	Orthosteric Ligand	8POK-H₂-Histamine-Gs/β1/γ2
5.56	Consensus	opsin1lw_on	Orthosteric Ligand	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.56	Consensus	opsin1lw_on_gp	Orthosteric Ligand	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.56	Consensus	opsins_on_gp	Orthosteric Ligand	rhodopsin_on_gp opsin1lw_on_gp
5.56	Consensus	rhodopsin_on	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.56	Consensus	sensory_on_gp	Orthosteric Ligand	opsins_on_gp
5.41	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
5.26	Single	1L9H	11-cis-Retinal	1L9H-Rhodopsin-11-cis-Retinal
5.26	Single	1U19	11-cis-Retinal	1U19-Rhodopsin-11-cis-Retinal
5.26	Single	2G87	All-trans-Retinal	2G87-Rhodopsin-All-trans-Retinal
5.26	Single	2I35	11-cis-Retinal	2I35-Rhodopsin-11-cis-Retinal
5.26	Single	3PBL	Eticlopride	3PBL-D₃-Eticlopride
5.26	Single	5L7I	Vismodegib	5L7I-SMO-Vismodegib
5.26	Single	5TE5	20-Methanoretinal	5TE5-Rhodopsin-20-Methanoretinal
5.26	Single	6I9K	9-cis-Retinal	6I9K-Rhodopsin-9-cis-Retinal
5.26	Single	6PGS	Geraniol	6PGS-Rhodopsin-Geraniol-Gt(CT)
5.26	Single	7D76	Beclomethasone	7D76-ADGRG3-Beclomethasone-Go/β1/γ2
5.26	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26	Single	7FEE	ZCZ011	7FEE-CB₁-CP55940-ZCZ011
5.26	Single	7SRQ	LSD	7SRQ-5-HT_2B-LSD
5.26	Single	7XKF	Beta-Hydroxyandrosterone	7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.26	Single	7XP6	Strychnine	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
5.26	Single	7XT9	Serotonin	7XT9-5-HT₄-Serotonin-Gs/β1/γ2
5.26	Single	7XTA	Serotonin	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
5.26	Single	7XTB	Serotonin	7XTB-5-HT₆-Serotonin-Gs/β1/γ2
5.26	Single	7YS6	Serotonin	7YS6-5-HT₆-Serotonin-chim(NtGi1-Gs)/β1/γ2
5.26	Single	8EF6	Morphine	8EF6-μ-Morphine-Gi1/β1/γ2
5.26	Single	8HNN	SCH546738	8HNN-CXCR3-SCH546738
5.26	Single	8J6P	Compound 9n	8J6P-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
5.26	Single	8JHY	Compound 9n	8JHY-HCA₂-Compound 9n-Gi1/β1/γ2
5.26	Single	8JII	Compound 9n	8JII-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
5.26	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.26	Single	8UO4	Constrained Epinephrine	8UO4-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
5.26	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26	Single	8X2K	Oleic monoethanolamide	8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
5.26	Single	8YH3	N-methyladenosine	8YH3-A_3A-N-methyladenosine-Gi1/β1/γ2
5.26	Single	8YKW	Succinic acid	8YKW-Succinate-Succinic acid-Gi1/β1/γ1
5.26	Single	8YN2	Histamine	8YN2-H₁-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26	Single	8ZSV	RO5263397	8ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
5.26	Single	9EPQ	11,20-Ethanoretinal	9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
5.26	Single	9IJE	Epinephrine	9IJE-β₃-Epinephrine-chim(NtGi1-Gs)/β1/γ2
5.26	Consensus	5ht4_on	Orthosteric Ligand	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
5.26	Consensus	5ht4_on_gp	Orthosteric Ligand	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
5.26	Consensus	d3_off	Orthosteric Ligand	3PBL-D₃-Eticlopride
5.00	Single	1GZM	11-cis-Retinal	1GZM-Rhodopsin-11-cis-Retinal
5.00	Single	2PED	9-cis-Retinal	2PED-Rhodopsin-9-cis-Retinal
5.00	Single	2X72	All-trans-Retinal	2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
5.00	Single	3C9L	11-cis-Retinal	3C9L-Rhodopsin-11-cis-Retinal
5.00	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
5.00	Single	5U09	Taranabant	5U09-CB₁-Taranabant
5.00	Single	5WS3	EMPA	5WS3-OX₂-EMPA
5.00	Single	6AKX	A4R	6AKX-CCR5-A4R
5.00	Single	6AKY	Maraviroc	6AKY-CCR5-Maraviroc
5.00	Single	6C1Q	NDT9513727	6C1Q-C5a₁-PMX53-NDT9513727
5.00	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
5.00	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
5.00	Single	6OBA	S-Alprenolol	6OBA-β₂-S-Alprenolol-GTPL11074
5.00	Single	6OYA	All-trans-Retinal	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.00	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
5.00	Single	7F1O	Dopamine	7F1O-D₁-Dopamine-GDP; Mg-Gs/β1/γ2
5.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00	Single	7SRR	LSD	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00	Single	7SRS	LSD	7SRS-5-HT_2B-LSD-Arrestin2
5.00	Single	7T6S	PubChem 24776341	7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
5.00	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/β1/γ2
5.00	Single	7X2F	Dopamine	7X2F-D₁-Dopamine-Mevidalen-Gs/β1/γ2
5.00	Single	7X5H	5-CT	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2
5.00	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/β1/γ2
5.00	Single	8A6C	All-trans-Retinal	8A6C-Rhodopsin-All-trans-Retinal
5.00	Single	8A6D	All-trans-Retinal	8A6D-Rhodopsin-All-trans-Retinal
5.00	Single	8A6E	All-trans-Retinal	8A6E-Rhodopsin-All-trans-Retinal
5.00	Single	8HMP	C17	8HMP-GPR52-C17-Gs/β1/γ2
5.00	Single	8JPP	Succinic acid	8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
5.00	Single	8JSO	AMPH	8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
5.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
5.00	Single	8U8F	Palmitic Acid	8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
5.00	Single	8UNS	Constrained Epinephrine	8UNS-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8UNT	Constrained Epinephrine	8UNT-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8WOG	Succinic acid	8WOG-Succinate-Succinic acid-Gi1/β1/γ2
5.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.00	Single	8XQN	Aristolochic acid A	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
5.00	Single	8XQR	Flufenamic acid	8XQR-TAS2R14-Flufenamic acid-Gt3/β1/γ1
5.00	Single	8XXV	Indomethacin	8XXV-DP₂-Indomethacin-A1D5Q-Gi1/β1/γ2
5.00	Single	8YKX	Maleic acid	8YKX-Succinate-Maleic acid-Gi1/β1/γ1
5.00	Single	8YUT	Amthamine	8YUT-H₂-Amthamine-Gs/β1/γ2
5.00	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.00	Single	9BQJ	RO76	9BQJ-μ-RO76-Gi1/β1/γ2
5.00	Single	9C2F	Ca; Ca; Tryptophan; '6218; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.00	Consensus	5ht2_on_gp	Orthosteric Ligand	5ht2b_on_gp
5.00	Consensus	5ht2b_on_gp	Orthosteric Ligand	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00	Consensus	5ht_on	Orthosteric Ligand	5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
5.00	Consensus	angiotensin_off	Orthosteric Ligand	at1_off
5.00	Consensus	gi_succinate	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
5.00	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
5.00	Consensus	gs_5ht	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2 7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2 7XT8-5-HT₄-Serotonin-Gs/β1/γ2
5.00	Consensus	orexin_off	Orthosteric Ligand	ox2_off ox1_off
5.00	Consensus	ox1_off	Orthosteric Ligand	6TP6-OX₁-Filorexant 6TP4-OX₁-ACT-462206 6V9S-OX₁-GTPL11403 6TOT-OX₁-Lemborexant 6TP3-OX₁-Nemorexant 6TQ6-OX₁-PubChem 145714283 6TQ9-OX₁-SB-408124 4ZJC-OX₁-SB-674042 4ZJ8-OX₁-Suvorexant 6TOD-OX₁-EMPA-Na 6TOS-OX₁-GSK1059865-Na 6TQ4-OX₁-PubChem 16046844-Na
5.00	Consensus	ox2_off	Orthosteric Ligand	5WQC-OX₂-EMPA 6TPN-OX₂-HTL6641 7XRR-OX₂-Lemborexant 6TPJ-OX₂-Suvorexant
5.00	Consensus	rhodopsin_off	Orthosteric Ligand	1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
5.00	Consensus	rhodopsin_on_gp	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.00	Consensus	s1p1_off	Orthosteric Ligand	3V2W-S1P₁-PubChem 51892645
5.00	Consensus	sensory_offon	Orthosteric Ligand	sensory_off sensory_on
5.00	Consensus	sensory_offon_gp	Orthosteric Ligand	sensory_on_gp sensory_on
5.00	Consensus	succinate_on	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
5.00	Consensus	succinate_on_gp	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
4.76	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
4.76	Single	3OAX	11-cis-Retinal	3OAX-Rhodopsin-11-cis-Retinal
4.76	Single	3RZE	Cidoxepin	3RZE-H₁-Cidoxepin
4.76	Single	3UZC	4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol	3UZC-A_2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
4.76	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
4.76	Single	4MBS	Maraviroc	4MBS-CCR5-Maraviroc
4.76	Single	4MQT	Iperoxo	4MQT-M₂-Iperoxo-LY2119620
4.76	Single	4ZUD	Olmesartan	4ZUD-AT₁-Olmesartan
4.76	Single	6A94	Zotepine	6A94-5-HT_2A-Zotepine
4.76	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
4.76	Single	6IQL	L745870	6IQL-D₄-L745870
4.76	Single	6KUX	RS-79948	6KUX-α_2a-RS-79948
4.76	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
4.76	Single	6PS5	S-Propranolol	6PS5-β₂-S-Propranolol
4.76	Single	6TPK	Retosiban	6TPK-OT-Retosiban
4.76	Single	6TPN	HTL6641	6TPN-OX₂-HTL6641
4.76	Single	6V9S	GTPL11403	6V9S-OX₁-GTPL11403
4.76	Single	7EJ8	Brimonidine	7EJ8-α_2a-Brimonidine-Go/β1/γ2
4.76	Single	7F61	PF-03654746	7F61-H₃-PF-03654746-Cholesterol
4.76	Single	7SR8	TAK-925	7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76	Single	7UL3	Famotidine	7UL3-H₂-Famotidine
4.76	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
4.76	Single	7VOD	Cariprazine	7VOD-5-HT_2A-Cariprazine
4.76	Single	7WC9	PubChem 162421364	7WC9-5-HT_2A-PubChem 162421364
4.76	Single	7WVU	fMLF	7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
4.76	Single	7XOV	SR146131	7XOV-CCK_A-SR146131-Gs/β1/γ2
4.76	Single	7YK6	PubChem 138319674	7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
4.76	Single	7ZBC	11-cis-Retinal	7ZBC-Rhodopsin-11-cis-Retinal
4.76	Single	7ZBE	11-cis-Retinal	7ZBE-Rhodopsin-11-cis-Retinal
4.76	Single	8FCZ	11-cis-Retinal	8FCZ-Rhodopsin-11-cis-Retinal
4.76	Single	8GG7	Constrained Epinephrine	8GG7-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8GGL	Constrained Epinephrine	8GGL-β₂-Constrained Epinephrine
4.76	Single	8GGM	Constrained Epinephrine	8GGM-β₂-Constrained Epinephrine
4.76	Single	8GGP	Constrained Epinephrine	8GGP-β₂-Constrained Epinephrine
4.76	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/β1/γ2
4.76	Single	8GUR	CP55,940	8GUR-CB₂-CP55,940-Gi1/β1/γ2
4.76	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	8JD6	N-(3-chlorophenyl)pyridine-2-carboxamide	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.76	Single	8JLQ	Fenoldopam	8JLQ-TA1-Fenoldopam-Gs/β1/γ2
4.76	Single	8JSP	Ulotaront	8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2
4.76	Single	8K2W	AMG487	8K2W-CXCR3-AMG487
4.76	Single	8K9K	Damgo	8K9K-μ-Damgo-Gi3/β1/γ1
4.76	Single	8K9L	Damgo	8K9L-μ-Damgo-VV9-Gi3/β1/γ1
4.76	Single	8RQL	Flufenamic acid	8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
4.76	Single	8UNL	Constrained Epinephrine	8UNL-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8UNO	Constrained Epinephrine	8UNO-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8UO1	Constrained Epinephrine	8UO1-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
4.76	Single	8V6U	PubChem 171392456	8V6U-5-HT_2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
4.76	Single	8VVG	GB18	8VVG-κ-GB18-Gi1/β1/γ2
4.76	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.76	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76	Single	8XQO	Aristolochic acid A	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.76	Single	8XQS	Flufenamic acid	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
4.76	Single	8Y62	C16:0 Ceramide	8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
4.76	Single	8ZMG	Pimavanserin	8ZMG-5-HT_2A-Pimavanserin
4.76	Single	8ZPM	AMD070	8ZPM-CXCR4-AMD070-Cholesterol
4.76	Single	8ZPN	AMD3100	8ZPN-CXCR4-AMD3100-Cholesterol
4.76	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.76	Single	9EPP	11,20-Ethanoretinal	9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
4.76	Single	9JKQ	METH	9JKQ-TA1-METH-Gs/β1/γ2
4.76	Consensus	5ht2a_off	Orthosteric Ligand	6A94-5-HT_2A-Zotepine 6A93-5-HT_2A-Risperidone 7VOD-5-HT_2A-Cariprazine 7WC8-5-HT_2A-Lumateperone 8JT8-5-HT_2A-(R)-IHCH-7179
4.76	Consensus	5ht_on_gp	Orthosteric Ligand	5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
4.76	Consensus	at1_off	Orthosteric Ligand	4YAY-AT₁-ZD-7155 4ZUD-AT₁-Olmesartan
4.76	Consensus	cb1_off	Orthosteric Ligand	5U09-CB₁-Taranabant 5TGZ-CB₁-AM6538
4.76	Consensus	cxcr3_off	Orthosteric Ligand	8K2W-CXCR3-AMG487
4.76	Consensus	ghrelin_off	Orthosteric Ligand	6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
4.76	Consensus	grh_off	Orthosteric Ligand	gnrh1_off
4.76	Consensus	opsins_off	Orthosteric Ligand	rhodopsin_off
4.76	Consensus	ot_off	Orthosteric Ligand	6TPK-OT-Retosiban
4.76	Consensus	sensory_off	Orthosteric Ligand	opsins_off
4.76	Consensus	vasop-oxy_off	Orthosteric Ligand	ot_off
4.55	Single	1HZX	11-cis-Retinal	1HZX-Rhodopsin-11-cis-Retinal
4.55	Single	2VT4	Cyanopindolol	2VT4-β₁-Cyanopindolol
4.55	Single	2Y01	Dobutamine	2Y01-β₁-Dobutamine
4.55	Single	2YCY	Cyanopindolol	2YCY-β₁-Cyanopindolol
4.55	Single	3ZPQ	4-(piperazin-1- yl)-1H-indole	3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na
4.55	Single	3ZPR	4-methyl-2-(piperazin-1-yl)	3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
4.55	Single	4YAY	ZD-7155	4YAY-AT₁-ZD-7155
4.55	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
4.55	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
4.55	Single	6DRX	Lisuride	6DRX-5-HT_2B-Lisuride
4.55	Single	6GPS	MK0812	6GPS-CCR2-MK0812
4.55	Single	6PRZ	S-Alprenolol	6PRZ-β₂-S-Alprenolol
4.55	Single	6PS2	S-Alprenolol	6PS2-β₂-S-Alprenolol
4.55	Single	6Z10	PubChem 154585554	6Z10-Succinate-PubChem 154585554
4.55	Single	7BU7	BI167107	7BU7-β₁-BI167107
4.55	Single	7CFM	P395	7CFM-GPBA-P395-Gs/β1/γ2
4.55	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/β1/γ2
4.55	Single	7F83	PF-05190457	7F83-Ghrelin-PF-05190457
4.55	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
4.55	Single	7JOZ	VFP	7JOZ-D₁-VFP-Gs/β1/γ2
4.55	Single	7RBT	PubChem 163183774	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
4.55	Single	7SQO	TAK-925	7SQO-OX₂-TAK-925-Gi1/β1/γ2
4.55	Single	7T6V	fMLFII	7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
4.55	Single	7UM6	Lisuride	7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2
4.55	Single	7VGZ	Remalteon	7VGZ-MT₁-Remalteon-Gi1/β1/γ2
4.55	Single	7VH0	Ramelteon	7VH0-MT₂-Ramelteon-Gi1/β1/γ1
4.55	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/β1/γ2
4.55	Single	7VIF	S-FTY720-P	7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2
4.55	Single	7WC7	Lisuride	7WC7-5-HT_2A-Lisuride
4.55	Single	7XJH	Isoproterenol	7XJH-β₃-Isoproterenol-Gs/β1/γ2
4.55	Single	7XTC	5-CT	7XTC-5-HT₇-5-CT-Gs/β1/γ2
4.55	Single	7YK7	DC591053	7YK7-RXFP4-DC591053-Gi2/β1/γ2
4.55	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
4.55	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
4.55	Single	8EFQ	Damgo	8EFQ-μ-Damgo-Gi1/β1/γ2
4.55	Single	8GCM	L902688	8GCM-EP₄-L902688-Gi1/β1/γ2
4.55	Single	8JD0	NAM563	8JD0-mGlu2; mGlu3-Glutamate-NAM563
4.55	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.55	Single	8UH3	Setiptiline	8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
4.55	Single	8XQL	Aristolochic acid A	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.55	Single	8YH5	Riboprine	8YH5-A_3A-Riboprine-Gi1/β1/γ2
4.55	Single	8YIC	SAR247799	8YIC-S1P₁-SAR247799-Gi1/β1/γ2
4.55	Single	8ZBE	Octreotide	8ZBE-SST5-Octreotide-Gi1/β1/γ1
4.55	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.55	Single	9B9Z	A1AKO	9B9Z-CB₁-A1AKO
4.55	Single	9CHX	S-Carazolol	9CHX-β₂-S-Carazolol
4.55	Consensus	5ht5_on	Orthosteric Ligand	5ht5a_on
4.55	Consensus	5ht5a_on	Orthosteric Ligand	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
4.55	Consensus	5ht7_on	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2
4.55	Consensus	5ht7_on_gp	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2
4.55	Consensus	alicarboxylic_off	Orthosteric Ligand	succinate_off
4.55	Consensus	ccr2_off	Orthosteric Ligand	6GPS-CCR2-MK0812
4.55	Consensus	gi_orexin	Orthosteric Ligand	7SQO-OX₂-TAK-925-Gi1/β1/γ2
4.55	Consensus	succinate_off	Orthosteric Ligand	6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
4.35	Single	2Y00	Dobutamine	2Y00-β₁-Dobutamine
4.35	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
4.35	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
4.35	Single	5T1A	PubChem 68764898; PubChem 12093170	5T1A-CCR2-PubChem 68764898; PubChem 12093170
4.35	Single	5YHL	PubChem 135121352	5YHL-EP₄-PubChem 135121352
4.35	Single	5YWY	ONO-AE3-208	5YWY-EP₄-ONO-AE3-208
4.35	Single	6E67	BI167107	6E67-β₂-BI167107-Gs (fused)
4.35	Single	6GPX	MK0812	6GPX-CCR2-MK0812
4.35	Single	6HLP	Netupitant	6HLP-NK₁-Netupitant
4.35	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
4.35	Single	6ME8	2-Phenylmelatonin	6ME8-MT₂-2-Phenylmelatonin
4.35	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/β1/γ2
4.35	Single	7BB7	AVP	7BB7-V₂-AVP-Gs/β1/γ2
4.35	Single	7C4S	S1P	7C4S-S1P₃-S1P
4.35	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/β1/γ2
4.35	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/β1/γ2
4.35	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/β1/γ2
4.35	Single	7EUO	fMLF	7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
4.35	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/β1/γ2
4.35	Single	7VFX	fMLF	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
4.35	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35	Single	8C9W	Etrumadenant	8C9W-A_2A-Etrumadenant
4.35	Single	8JXS	PF-6142	8JXS-D₁-PF-6142
4.35	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
4.35	Single	8S4D	CMF-019	8S4D-Apelin-CMF-019
4.35	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
4.35	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
4.35	Single	8TH4	Losartan	8TH4-AT₁-Losartan-AT118-L Nanobody
4.35	Single	8XQP	Cholesterol	8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.35	Single	9DQJ	EP-3945	9DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	9EAH	Olmesartan	9EAH-AT₁-Olmesartan-Nanobody AT209
4.35	Consensus	blt1_off	Orthosteric Ligand	5X33-BLT₁-BIIL260 7K15-BLT₁-MKD046-Na
4.35	Consensus	blt_off	Orthosteric Ligand	blt1_off
4.35	Consensus	cb2_on	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2
4.35	Consensus	cb2_on_gp	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2
4.35	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
4.35	Consensus	ep4_off	Orthosteric Ligand	5YWY-EP₄-ONO-AE3-208 5YHL-EP₄-PubChem 135121352
4.35	Consensus	ep_off	Orthosteric Ligand	ep4_off
4.35	Consensus	fpr1-alx_on	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
4.35	Consensus	fpr1-alx_on_gp	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
4.35	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
4.35	Consensus	lipid_on_gp	Orthosteric Ligand	cannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
4.35	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on p2y_on
4.35	Consensus	rxfp4_on	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
4.35	Consensus	rxfp4_on_gp	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
4.35	Consensus	s1p5_off	Orthosteric Ligand	7YXA-S1P₅-ONO-5430608
4.35	Consensus	s1p_off	Orthosteric Ligand	s1p1_off s1p5_off
4.17	Single	3P0G	BI167107	3P0G-β₂-BI167107
4.17	Single	3SN6	BI167107	3SN6-β₂-BI167107-Gs/β1/γ2
4.17	Single	5XR8	AM841	5XR8-CB₁-AM841
4.17	Single	5XRA	AM11542	5XRA-CB₁-AM11542
4.17	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
4.17	Single	6DDE	Damgo	6DDE-μ-Damgo-Gi1/β1/γ2
4.17	Single	6E59	L-760735	6E59-NK₁-L-760735
4.17	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
4.17	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
4.17	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/β1/γ2
4.17	Single	7B6W	Cyclazosin	7B6W-α_1b-Cyclazosin
4.17	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/β1/γ2
4.17	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/β1/γ2
4.17	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/β1/γ2
4.17	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/β1/γ2
4.17	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
4.17	Single	7XOW	Gastrin	7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2
4.17	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/β1/γ2
4.17	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/β1/γ2
4.17	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
4.17	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
4.17	Single	8ID6	Oleic acid	8ID6-FFA4-Oleic acid-Gi1/β1/γ2
4.17	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.17	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/β1/γ2
4.17	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.17	Single	8WU1	PubChem 119025665	8WU1-CB₁-PubChem 119025665-Arrestin2
4.17	Single	8XVL	Zibotentan	8XVL-ET_A-Zibotentan
4.17	Single	9B65	KCA	9B65-CB₁-KCA-Gi1/β1/γ2
4.17	Single	9BJK	NAM	9BJK-μ-Naloxone-NAM
4.17	Consensus	class-a_off	Orthosteric Ligand	sensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
4.17	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 6KPG-CB₁-AM841-Gi1/β1/γ2
4.17	Consensus	gi_relaxin	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
4.17	Consensus	motilin_on	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
4.17	Consensus	npy_off	Orthosteric Ligand	npy1_off npy2_off
4.17	Consensus	relaxin_on	Orthosteric Ligand	rxfp4_on
4.17	Consensus	relaxin_on_gp	Orthosteric Ligand	rxfp4_on_gp
4.17	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
4.00	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
4.00	Single	5F8U	Cyanopindolol	5F8U-β₁-Cyanopindolol
4.00	Single	5UNH	PubChem 126456406	5UNH-AT₂-PubChem 126456406
4.00	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/β1/γ2
4.00	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
4.00	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
4.00	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/β1/γ2
4.00	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
4.00	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Single	7L1V	PubChem 155491009	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Single	7SHE	PI; PE	7SHE-GPR158-PI; PE
4.00	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
4.00	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/β1/γ2
4.00	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
4.00	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
4.00	Single	8IBU	Erythromycin-A	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Single	8ID9	Eicosapentaenoic acid	8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
4.00	Single	8J6D	EP141	8J6D-C3a_B-EP141-Go/β1/γ2
4.00	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
4.00	Single	8JJP	Chemerin	8JJP-CML2-Chemerin-Gi1/β1/γ2
4.00	Single	8JWY	2-118	8JWY-A_2A-2-118
4.00	Single	8JWZ	AB928	8JWZ-A_2A-AB928-Na
4.00	Single	8T3Q	Docosa-4,7,10,13,16,19-Hexaenoic acid	8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00	Single	8W1V	PubChem 171716265	8W1V-β₂-PubChem 171716265
4.00	Single	8X8N	Octreotide	8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.00	Single	8XQS	Cholesterol	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
4.00	Single	9GYO	P395	9GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
4.00	Single	9L3W	Retinoic acid receptor responder protein 2	9L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
4.00	Consensus	cannabinoid_on	Orthosteric Ligand	cb2_on cb1_on
4.00	Consensus	cannabinoid_on_gp	Orthosteric Ligand	cb2_on_gp cb1_on_gp
4.00	Consensus	cb1_on	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
4.00	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
4.00	Consensus	leukotriene_off	Orthosteric Ligand	blt_off cyslt_off
4.00	Consensus	motilin_on_gp	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Consensus	orexin_on	Orthosteric Ligand	ox2_on
4.00	Consensus	s1p1_on	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
4.00	Consensus	s1p1_on_gp	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
4.00	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
3.85	Single	4NC3	Ergotamine	4NC3-5-HT_2B-Ergotamine
3.85	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
3.85	Single	6DDF	Damgo	6DDF-μ-Damgo-Gi1/β1/γ2
3.85	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/β1/γ2
3.85	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/β1/γ2
3.85	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
3.85	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
3.85	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/β1/γ2
3.85	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.85	Single	7SHF	PI; PE	7SHF-GPR158-PI; PE-B5; RGS7
3.85	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/β1/γ2
3.85	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
3.85	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/β1/γ2
3.85	Single	8GAG	PubChem 170838490	8GAG-CB₁-PubChem 170838490-Gi1/β1/γ2
3.85	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/β1/γ2
3.85	Single	8I95	EP54	8I95-C3a_B-EP54-Go/β1/γ2
3.85	Single	8K2X	CXCL10	8K2X-CXCR3-CXCL10-Gi1/β1/γ2
3.85	Single	9EAI	Losartan	9EAI-AT₁-Losartan-Nanobody AT209
3.85	Consensus	cb1_on_gp	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
3.85	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
3.85	Consensus	cck_on_gp	Orthosteric Ligand	ccka_on_gp cckb_on_gp
3.85	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
3.85	Consensus	ccka_on_gp	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
3.85	Consensus	chemerin_on	Orthosteric Ligand	cml1_on
3.85	Consensus	gi_s1p	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7EW3-S1P₃-S1P-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EW1-S1P₅-Siponimod-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
3.85	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85	Consensus	orexin_on_gp	Orthosteric Ligand	ox2_on_gp
3.85	Consensus	peptide_off	Orthosteric Ligand	cck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
3.85	Consensus	prostanoid_off	Orthosteric Ligand	ep_off dp_off
3.70	Single	5VBL	Apelin mimetic peptide agonist	5VBL-Apelin-Apelin mimetic peptide agonist
3.70	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/β1/γ2
3.70	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
3.70	Single	7XY6	BAY 60-6583	7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
3.70	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/β1/γ2
3.70	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/β1/γ2
3.70	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
3.70	Single	8XZF	WN561	8XZF-Apelin-WN561-Gi1/β1/γ2
3.70	Single	9ERX	D9-THC analog	9ERX-CB₁-D9-THC analog-Gi1/β1/γ2
3.70	Consensus	cxcr_on_gp	Orthosteric Ligand	cxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
3.70	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
3.70	Consensus	formylpeptide_on	Orthosteric Ligand	fpr2-alx_on fpr1-alx_on
3.70	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
3.70	Consensus	kiss1_on	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
3.70	Consensus	kisspeptin_on	Orthosteric Ligand	kiss1_on
3.70	Consensus	nmur1_on	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70	Consensus	ox2_on_gp	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
3.57	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
3.57	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
3.57	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
3.57	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57	Single	7W56	Neuromedin-S	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/β1/γ2
3.57	Single	8G59	TUG-891	8G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
3.57	Single	8GHV	AMG315	8GHV-CB₁-AMG315-Gi1/β1/γ2
3.57	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/β1/γ2
3.57	Single	8K3Z	CXCL12	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
3.57	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
3.57	Single	8WZ2	Orexigenic Neuropeptide QRFP	8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.57	Single	8ZJD	Kisspeptin-10	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
3.57	Single	9L3Y	Retinoic acid receptor responder protein 2	9L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
3.57	Consensus	chemerin_on_gp	Orthosteric Ligand	cml1_on_gp
3.57	Consensus	cml1_on	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
3.57	Consensus	cxcr4_on	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
3.57	Consensus	gi_chemerin	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
3.57	Consensus	gq_kisspeptin	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
3.57	Consensus	kiss1_on_gp	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
3.57	Consensus	kisspeptin_on_gp	Orthosteric Ligand	kiss1_on_gp
3.57	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
3.57	Consensus	lpl_on_gp	Orthosteric Ligand	s1p_on_gp lpa_on_gp
3.57	Consensus	nmur1_on_gp	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
3.57	Consensus	nop_on_gp	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
3.57	Consensus	somatostatin_off	Orthosteric Ligand	sst2_off
3.45	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
3.45	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
3.45	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
3.45	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/β1/γ2
3.45	Single	7SHE	PI; PE	7SHE-GPR158-PI; PE
3.45	Single	7SHF	PI; PE	7SHF-GPR158-PI; PE-B5; RGS7
3.45	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
3.45	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/β1/γ2
3.45	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
3.45	Single	8F7Q	Beta-Endorphin	8F7Q-μ-β-Endorphin-Gi1/β1/γ2
3.45	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/β1/γ2
3.45	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/β1/γ2
3.45	Single	8K6O	Pro-neuropeptide-Y	8K6O-Y₁-Pro-neuropeptide-Y-Gi2/β1/γ1
3.45	Single	8WSS	Pro-MCH	8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
3.45	Single	8Z7J	Agonistic antibody	8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
3.45	Consensus	cckb_on	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
3.45	Consensus	dop_on_gp	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
3.45	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
3.45	Consensus	s1p3_on_gp	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
3.45	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
3.33	Single	6VN7	PACAP	6VN7-VPAC₁-PACAP-Gs/β1/γ2
3.33	Single	7F4D	Alpha-MSH	7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2
3.33	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
3.33	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.33	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/β1/γ2
3.33	Single	8XIR	Pasireotide	8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
3.33	Single	8XZG	Apelin-13	8XZG-Apelin-Apelin-13-Gi1/β1/γ2
3.33	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/β1/γ2
3.33	Single	9K27	PrRP31	9K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
3.33	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
3.33	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
3.33	Consensus	cckb_on_gp	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
3.33	Consensus	cxcr4_on_gp	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
3.33	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
3.33	Consensus	gs_class-a	Orthosteric Ligand	gs_peptide gs_nucleotide gs_amine
3.33	Consensus	peptide_offon	Orthosteric Ligand	peptide_off peptide_on
3.23	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
3.23	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
3.23	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/β1/γ2
3.23	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/β1/γ2
3.23	Single	7DW9	AVP	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
3.23	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
3.23	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
3.23	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
3.23	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
3.23	Single	7T10	Somatostatin-14	7T10-SST2-Somatostatin-14-Gi3/β1/γ2
3.23	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
3.23	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2
3.23	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
3.23	Single	8XWQ	Endothelin-1	8XWQ-ET_B-Endothelin-1-Gi1/β1/γ2
3.23	Single	8YW3	Retatrutide	8YW3-GLP-1-Retatrutide-Gs/β1/γ2
3.23	Single	8YW4	Retatrutide	8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
3.23	Consensus	angiotensin_on_gp	Orthosteric Ligand	at1_on_gp
3.23	Consensus	apelin_on	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
3.23	Consensus	apelin_on_gp	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
3.23	Consensus	at1_on_gp	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
3.23	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
3.23	Consensus	gs_vasop-oxy	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
3.23	Consensus	neuromedin-u_on	Orthosteric Ligand	nmur1_on nmur2_on
3.23	Consensus	peptide_offon_gp	Orthosteric Ligand	peptide_on_gp peptide_off
3.23	Consensus	protein_on	Orthosteric Ligand	chemokine_on chemerin_on
3.23	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
3.23	Consensus	v2_on_gp	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
3.23	Consensus	vasop-oxy_on	Orthosteric Ligand	v2_on
3.23	Consensus	vasop-oxy_on_gp	Orthosteric Ligand	v2_on_gp
3.12	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/β1/γ2
3.12	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
3.12	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/β1/γ2
3.12	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
3.12	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
3.12	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/β1/γ2
3.12	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/β1/γ2
3.12	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
3.12	Single	8XQE	Apelin-13	8XQE-Apelin-Apelin-13-Gi1/β1/γ2
3.12	Single	8XVH	Endothelin-1	8XVH-ET_B-Endothelin-1-chim(Gs-CtGq)/β1/γ2
3.12	Single	8ZPS	PrRP20	8ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12	Single	8ZRT	ET-1	8ZRT-ET_B-ET-1
3.12	Consensus	chemokine_off	Orthosteric Ligand	ccr_off cxcr_off
3.12	Consensus	cxcr_off	Orthosteric Ligand	cxcr3_off cxcr4_off
3.12	Consensus	gi_apelin	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
3.12	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
3.12	Consensus	mc1_on_gp	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
3.12	Consensus	neuromedin-u_on_gp	Orthosteric Ligand	nmur1_on_gp nmur2_on_gp
3.03	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
3.03	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
3.03	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
3.03	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
3.03	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.03	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
3.03	Single	8XQF	Apelin-13	8XQF-Apelin-Apelin-13-Gi1/β1/γ2
3.03	Single	8XVE	BQ3020	8XVE-ET_B-BQ3020-chim(Gs-CtGq)/β1/γ2
3.03	Single	9J1P	g1:Ox	9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
3.03	Consensus	ccr_off	Orthosteric Ligand	ccr2_off ccr5_off
3.03	Consensus	gi_peptide	Orthosteric Ligand	gi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
3.03	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
3.03	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
3.03	Consensus	npy4_on_gp	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
3.03	Consensus	protein_on_gp	Orthosteric Ligand	chemokine_on_gp chemerin_on_gp
2.94	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
2.94	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
2.94	Single	7F53	Alpha-MSH	7F53-MC₄-α-MSH-Gs/β1/γ2
2.94	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
2.94	Single	7YOO	Neuropeptide-Y	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
2.94	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
2.94	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
2.94	Single	8XWP	Endothelin-1	8XWP-ET_B-Endothelin-1-Gi1/β1/γ2
2.94	Single	8ZJG	Chemerin	8ZJG-CML1-Chemerin-Gi1/β1/γ2
2.94	Single	9K26	PrRP31	9K26-PrRP-PrRP31-Gi1/β1/γ2
2.94	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
2.94	Consensus	npy2_on_gp	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
2.94	Consensus	peptide_on	Orthosteric Ligand	cck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
2.94	Consensus	peptide_on_gp	Orthosteric Ligand	cck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
2.86	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
2.86	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/β1/γ2
2.86	Single	7VGX	Neuropeptide-Y	7VGX-Y₁-Neuropeptide-Y-Gi1/β1/γ2
2.86	Single	8Y52	BA1	8Y52-BB₃-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
2.78	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
2.78	Single	8ZJE	TAK-448	8ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
2.78	Consensus	gi_npy	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
2.78	Consensus	npy_on	Orthosteric Ligand	npy1_on npy2_on npy4_on
2.78	Consensus	npy_on_gp	Orthosteric Ligand	npy1_on_gp npy2_on_gp npy4_on_gp
2.63	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/β1/γ2
2.63	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
2.63	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
2.63	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_melanocortin gs_vasop-oxy
2.56	Single	7X9A	Neuropeptide-Y	7X9A-Y₁-Neuropeptide-Y-Gi1/β1/γ2
2.56	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/β1/γ2
2.56	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/β1/γ2

PDB Summary
PDB	8T6J
Class	C
SubFamily	Aminoacid
Type	Metabotropic Glutamate
SubType	mGlu5; mGlu5
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	CDPPB
Protein Partners	-
PDB Resolution	3.5
Date	2023-10-11
D.O.I.	10.1101/2023.08.29.555158

Net Summary
I_min	1.75
Number of Linked Nodes	1412
Number of Links	1657
Number of Hubs	215
Number of Links mediated by Hubs	830
Number of Communities	55
Number of Nodes involved in Communities	393
Number of Links involved in Communities	524

Path Summary
Number Of Nodes in MetaPath	142
Number Of Links MetaPath	141
Number of Shortest Paths	7226726
Length Of Smallest Path	3
Average Path Length	76.7099
Length of Longest Path	153
Minimum Path Strength	1.06
Average Path Strength	4.14192
Maximum Path Strength	22.685
Minimum Path Correlation	0.72
Average Path Correlation	0.998998
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.89855
Average % Of Corr. Nodes	40.464
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.2519
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein tyrosine kinase activator activity • enzyme regulator activity • catalytic activity, acting on a protein • molecular function activator activity • kinase activity • protein kinase activity • transferase activity • protein kinase regulator activity • phosphotransferase activity, alcohol group as acceptor • transferase activity, transferring phosphorus-containing groups • kinase activator activity • enzyme activator activity • protein tyrosine kinase activity • molecular function regulator activity • catalytic activity • protein kinase activator activity • kinase regulator activity • glutamate receptor activity • G protein-coupled glutamate receptor activity • molecular transducer activity • adenylate cyclase inhibiting G protein-coupled glutamate receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • protein binding • binding • A2A adenosine receptor binding • signaling receptor binding • G protein-coupled receptor binding • adenosine receptor binding • neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration • neurotransmitter receptor activity • postsynaptic neurotransmitter receptor activity • G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential • protein tyrosine kinase binding • kinase binding • enzyme binding • protein kinase binding • identical protein binding • behavior • multicellular organismal process • locomotory behavior • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus
Gene Ontology	Biological Process	• behavior • multicellular organismal process • locomotory behavior • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • biological regulation • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • cellular process • positive regulation of signaling • system process • learning • learning or memory • nervous system process • cognition • negative adaptation of signaling pathway • negative regulation of signaling • negative regulation of biological process • desensitization of G protein-coupled receptor signaling pathway • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • negative regulation of response to stimulus • negative regulation of signal transduction • adaptation of signaling pathway • G protein-coupled receptor signaling pathway • cellular component organization • cell junction organization • synapse organization • cellular component organization or biogenesis • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • RNA metabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • primary metabolic process • regulation of macromolecule metabolic process • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • regulation of gene expression • biosynthetic process • metabolic process • regulation of macromolecule biosynthetic process • regulation of DNA-templated transcription • macromolecule metabolic process • regulation of metabolic process • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • cell surface receptor signaling pathway • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway • glutamate receptor signaling pathway • G protein-coupled glutamate receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • positive regulation of nervous system development • regulation of long-term neuronal synaptic plasticity • regulation of developmental process • cellular developmental process • modulation of chemical synaptic transmission • cell development • regulation of cell differentiation • regulation of neurogenesis • regulation of cell development • regulation of nervous system development • positive regulation of developmental process • multicellular organism development • neurogenesis • positive regulation of cell differentiation • cell differentiation • anatomical structure development • positive regulation of long-term neuronal synaptic plasticity • positive regulation of neurogenesis • regulation of multicellular organismal process • regulation of biological quality • system development • regulation of neuronal synaptic plasticity • regulation of synaptic plasticity • developmental process • regulation of multicellular organismal development • positive regulation of cell development • nervous system development • regulation of trans-synaptic signaling • positive regulation of multicellular organismal process • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • cellular response to nitrogen compound • response to oxygen-containing compound • response to nitrogen compound • cellular response to amyloid-beta • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • response to amyloid-beta • postsynaptic specialization membrane • postsynaptic specialization • synapse • membrane • plasma membrane • postsynaptic density membrane • synaptic membrane • cell periphery • postsynaptic density • postsynapse • cellular anatomical structure • neuron to neuron synapse • organelle • cell junction
Gene Ontology	Cellular Component	• postsynaptic specialization membrane • postsynaptic specialization • synapse • membrane • plasma membrane • postsynaptic density membrane • synaptic membrane • cell periphery • postsynaptic density • postsynapse • cellular anatomical structure • neuron to neuron synapse • organelle • cell junction • postsynaptic membrane • asymmetric synapse • plasma membrane region • glial cell projection • cell projection • plasma membrane bounded cell projection • astrocyte projection • somatodendritic compartment • dendrite • dendritic tree • neuron projection • intracellular anatomical structure • cytoplasm • glutamatergic synapse • dendritic shaft • neuron spine • dendritic spine • Schaffer collateral - CA1 synapse • cell body • neuronal cell body
SCOP2	Domain Identifier	• TNF receptor-like • G protein-coupled receptor-like • Type 1 solute binding protein-like
SCOP2	Family Identifier	• TNF receptor-like • G protein-coupled receptor-like • Type 1 solute binding protein-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	YKU
PDB Residues	X:X:?1 W:W:?1
Environment Details	Open EMBL-EBI Page
Code	YKU
Name	3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
Synonyms
Identifier
Formula	C23 H16 N4 O
Molecular Weight	364.399
SMILES
PubChem	11245456
Formal Charge	0
Total Atoms	44
Total Chiral Atoms	0
Total Bonds	47
Total Aromatic Bonds	23


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41594
Sequence	>8T6J_Chain_R R V V A H M P G D I I I G A L F S V H H Q P T V D K V H E R K C G A V R E Q Y G I Q R V E A M L H T L E R I N S D P T L L P N I T L G C E I R D S C W H S A V A L E Q S I E F I R D S L K K P I V G V I G P G S S S V A I Q V Q N L L Q L F N I P Q I A Y S A T S M D L S D K T L F K Y F M R V V P S D A Q Q A R A M V D I V K R Y N W T Y V S A V H T E G N Y G E S G M E A F K D M S A K E G I C I A H S Y K I Y S N A G E Q S F D K L L K K L T S H L P K A R V V A C F C E G M T V R G L L M A M R R L G L A G E F L L L G S D G W A D R Y D V T D G Y Q R E A V G G I T I K L Q S P D V K W F D D Y Y L K L R P E T N H R N P W F Q E F W Q H R F Q C R L E G F P Q E N S K Y N K T C N S S L T L K T H H V Q D S K M G F V I N A I Y S M A Y G L H N M Q M S L C P G Y A G L C D A M K P I D G R K L L E S L M K T N F T G V S G D T I L F D E N G D S P G R Y E I M N F K E M G K D Y F D Y I N V G S W D N G E L K M D D D E V W S K K S N I I R S V C S E P C E K G Q I K V I R K G E V S C C W T C T P C K E N E Y V F D E Y T C K A C Q L G S W P T D D L T G C D L I P V Q Y L R W G D P E P I A A V V F A C L G L L A T L F V T V V F I I Y R D T P V V K S S S R E L C Y I I L A G I C L G Y L C T F C L I A K P K Q I Y C Y L Q R I G I G L S P A M S Y S A L V T K T N R I A R I L F M S A C A Q L V I A F I L I C I Q L G I I V A L F I M E P P D I M H D Y P S I R E V Y L I C N T T N L G V V T P L G Y N G L L I L S C T F Y A F K T R N V P A N F N E A K Y I A F T M Y T T C I I W L A F V P I Y F G S N Y K I I T M C F S V S L S A T V A L G C M F V P K V Y I I L A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	S
Protein	Receptor
UniProt	P41594
Sequence	>8T6J_Chain_S R V V A H M P G D I I I G A L F S V H H Q P T V D K V H E R K C G A V R E Q Y G I Q R V E A M L H T L E R I N S D P T L L P N I T L G C E I R D S C W H S A V A L E Q S I E F I R D S L K K P I V G V I G P G S S S V A I Q V Q N L L Q L F N I P Q I A Y S A T S M D L S D K T L F K Y F M R V V P S D A Q Q A R A M V D I V K R Y N W T Y V S A V H T E G N Y G E S G M E A F K D M S A K E G I C I A H S Y K I Y S N A G E Q S F D K L L K K L T S H L P K A R V V A C F C E G M T V R G L L M A M R R L G L A G E F L L L G S D G W A D R Y D V T D G Y Q R E A V G G I T I K L Q S P D V K W F D D Y Y L K L R P E T N H R N P W F Q E F W Q H R F Q C R L E G F P Q E N S K Y N K T C N S S L T L K T H H V Q D S K M G F V I N A I Y S M A Y G L H N M Q M S L C P G Y A G L C D A M K P I D G R K L L E S L M K T N F T G V S G D T I L F D E N G D S P G R Y E I M N F K E M G K D Y F D Y I N V G S W D N G E L K M D D D E V W S K K S N I I R S V C S E P C E K G Q I K V I R K G E V S C C W T C T P C K E N E Y V F D E Y T C K A C Q L G S W P T D D L T G C D L I P V Q Y L R W G D P E P I A A V V F A C L G L L A T L F V T V V F I I Y R D T P V V K S S S R E L C Y I I L A G I C L G Y L C T F C L I A K P K Q I Y C Y L Q R I G I G L S P A M S Y S A L V T K T N R I A R I L F M S A C A Q L V I A F I L I C I Q L G I I V A L F I M E P P D I M H D Y P S I R E V Y L I C N T T N L G V V T P L G Y N G L L I L S C T F Y A F K T R N V P A N F N E A K Y I A F T M Y T T C I I W L A F V P I Y F G S N Y K I I T M C F S V S L S A T V A L G C M F V P K V Y I I L A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8X0H	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	Quisqualate	-	-	4.1	2024-11-06	doi.org/10.1038/s41467-024-55439-9
	8X0G	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	Quisqualate	-	-	3	2024-11-06	doi.org/10.1038/s41467-024-55439-9
	8X0F	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	Quisqualate	VU0424465	-	3.3	2024-11-06	doi.org/10.1038/s41467-024-55439-9
	8X0E	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	Quisqualate	-	-	3.4	2024-11-06	doi.org/10.1038/s41467-024-55439-9
	8X0D	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	Quisqualate	VU0424465	-	3.5	2024-11-06	doi.org/10.1038/s41467-024-55439-9
	8X0C	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	Quisqualate	VU0424465	-	3.2	2024-11-06	doi.org/10.1038/s41467-024-55439-9
	8X0B	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	Quisqualate	VU0424465	-	3.1	2024-11-06	doi.org/10.1038/s41467-024-55439-9
	8TAO	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	Quisqualate	CDPPB	-	2.9	2023-10-11	10.1101/2023.08.29.555158
	8T8M	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	Quisqualate	-	-	3	2023-10-11	10.1101/2023.08.29.555158
	8T7H	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	Quisqualate	-	-	3.3	2023-10-11	10.1101/2023.08.29.555158
	8T6J	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	-	CDPPB	-	3.5	2023-10-11	10.1101/2023.08.29.555158
	7P2L	C	Aminoacid	Metabotropic Glutamate	mGlu₅	Homo sapiens	-	4YI	-	2.54	2021-09-08	10.1016/j.celrep.2021.109648
	7FD9	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	LY341495	-	-	4	2021-09-08	10.1016/j.celrep.2021.109648
	7FD8	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	Quisqualate	-	-	3.8	2021-09-08	10.1016/j.celrep.2021.109648
	6N52	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	-	-	-	4	2019-01-23	10.1038/s41586-019-0881-4
	6N51	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	Quisqualate	-	-	4	2019-01-23	10.1038/s41586-019-0881-4
	6FFI	C	Aminoacid	Metabotropic Glutamate	mGlu₅	Homo sapiens	-	MMPEP	-	2.2	2018-03-07	10.1021/acs.jmedchem.7b01722
	6FFH	C	Aminoacid	Metabotropic Glutamate	mGlu₅	Homo sapiens	-	Fenobam	-	2.65	2018-03-07	10.1021/acs.jmedchem.7b01722
	5CGD	C	Aminoacid	Metabotropic Glutamate	mGlu₅	Homo sapiens	-	HTL14242	-	2.6	2015-08-12	10.1021/acs.jmedchem.5b00892
	5CGC	C	Aminoacid	Metabotropic Glutamate	mGlu₅	Homo sapiens	-	HTL14242	-	3.1	2015-08-12	10.1021/acs.jmedchem.5b00892
	4OO9	C	Aminoacid	Metabotropic Glutamate	mGlu₅	Homo sapiens	-	Mavoglurant	-	2.6	2014-07-02	10.1038/nature13396

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