psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T314	R:R:T69	3.14	No	No	0	1	4
2	R:R:I73	R:R:Y130	9.67	No	No	19	6	5
3	R:R:H321	R:R:I73	7.95	Yes	No	19	4	6
4	R:R:M74	R:R:S127	3.07	No	No	0	5	6
5	R:R:L131	R:R:M74	9.9	No	No	0	4	5
6	R:R:F322	R:R:L76	4.87	No	No	0	4	5
7	R:R:A325	R:R:L76	3.15	No	No	0	6	5
8	R:R:L123	R:R:Y77	3.52	Yes	No	0	7	7
9	R:R:S127	R:R:Y77	6.36	No	No	0	6	7
10	R:R:H321	R:R:Y77	13.07	Yes	No	0	4	7
11	R:R:L123	R:R:V80	2.98	Yes	No	0	7	7
12	R:R:C81	R:R:L85	3.17	Yes	No	20	6	6
13	R:R:C81	R:R:T120	3.38	Yes	No	20	6	5
14	R:R:C81	R:R:L123	4.76	Yes	Yes	0	6	7
15	R:R:C81	R:R:P124	3.77	Yes	No	0	6	8
16	R:R:C332	R:R:V83	3.42	No	No	0	8	5
17	R:R:C332	R:R:G84	3.92	No	No	0	8	8
18	R:R:F89	R:R:L85	3.65	No	No	0	4	6
19	R:R:L85	R:R:T120	5.9	No	No	20	6	5
20	R:R:D116	R:R:N88	6.73	Yes	No	0	9	9
21	R:R:A117	R:R:N88	4.69	No	No	0	7	9
22	R:R:N88	R:R:P335	4.89	No	No	0	9	9
23	R:R:F89	R:R:M92	3.73	No	No	0	4	7
24	R:R:A117	R:R:F89	2.77	No	No	0	7	4
25	R:R:F340	R:R:L90	2.44	Yes	No	0	6	6
26	R:R:I95	R:R:V91	3.07	No	Yes	0	7	9
27	R:R:A113	R:R:V91	3.39	No	Yes	0	9	9
28	R:R:P335	R:R:V91	3.53	No	Yes	0	9	9
29	R:R:A339	R:R:V91	3.39	No	Yes	0	6	9
30	R:R:F340	R:R:V91	2.62	Yes	Yes	0	6	9
31	R:R:F110	R:R:M92	6.22	Yes	No	0	6	7
32	R:R:R97	R:R:Y93	10.29	No	No	0	5	4
33	R:R:F349	R:R:V94	3.93	No	No	0	6	7
34	R:R:F110	R:R:I95	7.54	Yes	No	0	6	7
35	R:R:F345	R:R:I95	5.02	Yes	No	0	8	7
36	R:R:F110	R:R:V96	2.62	Yes	No	0	6	3
37	R:R:R97	R:R:Y98	4.12	No	No	0	5	4
38	R:R:F352	R:R:Y98	18.57	No	No	0	7	4
39	R:R:N106	R:R:T99	5.85	No	No	0	8	6
40	R:R:F110	R:R:M101	4.98	Yes	No	0	6	7
41	R:R:N106	R:R:T103	4.39	No	No	0	8	7
42	A:A:D350	R:R:T103	5.78	No	No	0	4	7
43	R:R:A104	R:R:R181	2.77	No	Yes	0	5	7
44	R:R:R181	R:R:T105	6.47	Yes	No	22	7	8
45	A:A:D350	R:R:T105	5.78	No	No	22	4	8
46	R:R:F345	R:R:N106	7.25	Yes	No	0	8	8
47	R:R:I107	R:R:K187	2.91	No	No	0	5	2
48	R:R:I107	R:R:N190	2.83	No	Yes	0	5	7
49	R:R:T162	R:R:Y108	6.24	No	Yes	0	7	7
50	R:R:M163	R:R:Y108	5.99	No	Yes	0	9	7
51	R:R:D166	R:R:Y108	5.75	No	Yes	0	8	7
52	R:R:A186	R:R:Y108	4	No	Yes	0	7	7
53	R:R:N190	R:R:Y108	10.47	Yes	Yes	0	7	7
54	R:R:D342	R:R:I109	2.8	No	No	21	8	8
55	R:R:F345	R:R:I109	6.28	Yes	No	21	8	8
56	R:R:N111	R:R:N190	6.81	No	Yes	0	9	7
57	R:R:N111	R:R:W194	4.52	No	No	0	9	9
58	R:R:L112	R:R:T159	5.9	No	No	0	9	8
59	R:R:L112	R:R:L160	5.54	No	Yes	0	9	8
60	R:R:L112	R:R:M163	2.83	No	No	0	9	9
61	R:R:L114	R:R:L118	4.15	No	No	0	7	7
62	R:R:A115	R:R:T155	3.36	No	Yes	0	8	7
63	R:R:D116	R:R:S156	7.36	Yes	No	0	9	9
64	R:R:D116	R:R:S331	10.31	Yes	No	3	9	9
65	R:R:D116	R:R:N334	8.08	Yes	Yes	3	9	9
66	R:R:L118	R:R:N152	10.98	No	No	0	7	8
67	R:R:A119	R:R:N152	3.13	No	No	0	7	8
68	R:R:T122	R:R:V145	4.76	Yes	Yes	0	6	5
69	R:R:I148	R:R:T122	3.04	No	Yes	0	5	6
70	R:R:D149	R:R:T122	4.34	Yes	Yes	0	5	6
71	R:R:L123	R:R:Y328	4.69	Yes	Yes	0	7	7
72	R:R:F125	R:R:F137	4.29	No	Yes	0	6	6
73	R:R:F125	R:R:V145	6.55	No	Yes	0	6	5
74	R:R:D149	R:R:Q126	7.83	Yes	No	3	5	6
75	R:R:Q126	R:R:Y328	6.76	No	Yes	3	6	7
76	L:L:?1	R:R:Q126	11.19	Yes	No	3	0	6
77	R:R:F137	R:R:V128	6.55	Yes	No	0	6	3
78	R:R:N129	R:R:W135	9.04	No	Yes	3	4	8
79	L:L:?1	R:R:N129	2.66	Yes	No	3	0	4
80	R:R:T317	R:R:Y130	3.75	No	No	0	4	5
81	R:R:H321	R:R:Y130	11.98	Yes	No	19	4	5
82	R:R:S216	R:R:T134	3.2	No	No	0	1	5
83	R:R:I217	R:R:T134	3.04	No	No	0	4	5
84	R:R:P136	R:R:W135	2.7	No	Yes	3	3	8
85	R:R:F137	R:R:W135	23.05	Yes	Yes	3	6	8
86	R:R:C142	R:R:W135	5.22	No	Yes	3	9	8
87	R:R:V145	R:R:W135	6.13	Yes	Yes	0	5	8
88	R:R:C219	R:R:W135	18.28	No	Yes	3	9	8
89	L:L:?1	R:R:W135	2.95	Yes	Yes	3	0	8
90	R:R:F137	R:R:P136	4.33	Yes	No	3	6	3
91	R:R:F137	R:R:L141	6.09	Yes	No	0	6	5
92	R:R:T139	R:R:T210	7.85	No	No	0	3	4
93	R:R:L141	R:R:V145	2.98	No	Yes	0	5	5
94	R:R:C142	R:R:T210	3.38	No	No	0	9	4
95	R:R:C142	R:R:C219	7.28	No	No	3	9	9
96	R:R:I144	R:R:I148	2.94	No	No	0	5	5
97	R:R:A208	R:R:I146	3.25	No	Yes	0	5	4
98	R:R:C219	R:R:I146	3.27	No	Yes	0	9	4
99	R:R:I146	R:R:L221	2.85	Yes	No	0	4	4
100	L:L:?1	R:R:I146	2.77	Yes	Yes	0	0	4
101	R:R:M205	R:R:S147	7.67	No	No	0	5	6
102	R:R:I148	R:R:N152	4.25	No	No	0	5	8
103	R:R:D149	R:R:Y328	8.05	Yes	Yes	3	5	7
104	L:L:?1	R:R:D149	11.41	Yes	Yes	3	0	5
105	R:R:V204	R:R:Y150	3.79	No	No	0	5	4
106	R:R:L221	R:R:Y150	3.52	No	No	0	4	4
107	L:L:?1	R:R:Y150	6.07	Yes	No	0	0	4
108	R:R:T155	R:R:Y151	7.49	Yes	Yes	3	7	5
109	R:R:W194	R:R:Y151	10.61	No	Yes	3	9	5
110	R:R:S197	R:R:Y151	3.82	Yes	Yes	3	8	5
111	R:R:G201	R:R:Y151	2.9	No	Yes	0	6	5
112	R:R:F154	R:R:M153	3.73	Yes	No	3	6	7
113	R:R:M153	R:R:W295	4.65	No	Yes	3	7	8
114	L:L:?1	R:R:M153	9.14	Yes	No	3	0	7
115	R:R:F154	R:R:F158	5.36	Yes	No	3	6	5
116	R:R:F154	R:R:S197	2.64	Yes	Yes	3	6	8
117	R:R:F154	R:R:I200	6.28	Yes	No	0	6	5
118	R:R:F154	R:R:V238	2.62	Yes	No	0	6	5
119	R:R:A242	R:R:F154	2.77	No	Yes	0	5	6
120	R:R:T155	R:R:W194	14.55	Yes	No	3	7	9
121	R:R:S197	R:R:T155	6.4	Yes	Yes	3	8	7
122	R:R:I157	R:R:P246	3.39	No	Yes	3	7	8
123	R:R:F291	R:R:I157	7.54	Yes	No	3	9	7
124	R:R:I157	R:R:W295	7.05	No	Yes	3	7	8
125	R:R:F158	R:R:S197	2.64	No	Yes	3	5	8
126	R:R:F291	R:R:L160	2.44	Yes	Yes	3	9	8
127	R:R:L160	R:R:N334	2.75	Yes	Yes	3	8	9
128	R:R:L160	R:R:Y338	8.21	Yes	Yes	3	8	9
129	R:R:C161	R:R:P246	3.77	No	Yes	0	7	8
130	R:R:C161	R:R:I249	4.91	No	No	0	7	6
131	R:R:N193	R:R:T162	7.31	No	No	0	7	7
132	R:R:I250	R:R:S164	4.64	No	No	3	8	9
133	R:R:C253	R:R:S164	5.16	No	No	0	8	9
134	R:R:S164	R:R:Y254	10.17	No	Yes	3	9	9
135	R:R:I169	R:R:V165	3.07	No	No	0	5	6
136	R:R:D166	R:R:F180	5.97	No	Yes	0	8	3
137	R:R:D166	R:R:R181	16.68	No	Yes	0	8	7
138	R:R:R167	R:R:Y254	8.23	No	Yes	0	9	9
139	R:R:R167	R:R:Y338	6.17	No	Yes	0	9	9
140	A:A:L353	R:R:R167	14.58	No	No	0	7	9
141	R:R:C172	R:R:Y168	8.06	No	Yes	24	7	8
142	R:R:H173	R:R:Y168	4.36	No	Yes	24	6	8
143	R:R:C253	R:R:Y168	6.72	No	Yes	0	8	8
144	R:R:L256	R:R:Y168	7.03	No	Yes	0	5	8
145	R:R:F180	R:R:I169	12.56	Yes	No	0	3	5
146	R:R:A170	R:R:R181	2.77	No	Yes	0	8	7
147	A:A:N347	R:R:A170	4.69	No	No	0	8	8
148	R:R:M257	R:R:V171	7.61	No	Yes	10	8	8
149	R:R:R260	R:R:V171	2.62	Yes	Yes	0	5	8
150	R:R:L261	R:R:V171	4.47	Yes	Yes	10	8	8
151	A:A:L348	R:R:V171	2.98	Yes	Yes	10	9	8
152	R:R:C172	R:R:H173	2.95	No	No	24	7	6
153	R:R:C172	R:R:R260	4.18	No	Yes	0	7	5
154	A:A:T340	R:R:P174	5.25	No	No	0	6	8
155	A:A:I343	R:R:P174	3.39	No	No	0	7	8
156	A:A:I344	R:R:P174	5.08	Yes	No	0	6	8
157	A:A:L194	R:R:V175	4.47	Yes	No	4	4	6
158	A:A:F336	R:R:V175	2.62	Yes	No	4	8	6
159	A:A:R32	R:R:D179	5.96	No	No	0	4	5
160	R:R:F180	R:R:N185	4.83	Yes	Yes	23	3	4
161	R:R:F180	R:R:I189	3.77	Yes	No	23	3	5
162	A:A:D350	R:R:R181	5.96	No	Yes	22	4	7
163	A:A:C351	R:R:R181	5.57	No	Yes	0	4	7
164	R:R:I188	R:R:R184	2.51	No	No	0	3	3
165	R:R:I189	R:R:N185	7.08	No	Yes	23	5	4
166	R:R:N190	R:R:N193	2.72	Yes	No	0	7	7
167	R:R:I195	R:R:V191	3.07	No	No	0	4	4
168	R:R:L202	R:R:S198	6.01	No	No	0	4	4
169	R:R:I200	R:R:L234	2.85	No	No	0	5	6
170	R:R:L202	R:R:M205	2.83	No	No	0	4	5
171	R:R:F223	R:R:M207	4.98	Yes	No	0	6	5
172	R:R:T209	R:R:T222	6.28	No	No	0	5	4
173	R:R:I217	R:R:T210	3.04	No	No	0	4	4
174	R:R:K211	R:R:T222	10.51	No	No	0	1	4
175	R:R:I217	R:R:Y212	3.63	No	No	0	4	3
176	R:R:D218	R:R:T220	7.23	No	No	0	4	4
177	R:R:F223	R:R:L221	3.65	Yes	No	0	6	4
178	R:R:F223	R:R:W230	3.01	Yes	Yes	0	6	1
179	R:R:E231	R:R:F223	9.33	No	Yes	0	4	6
180	R:R:F223	R:R:L234	4.87	Yes	No	0	6	6
181	R:R:S224	R:R:W230	4.94	No	Yes	0	3	1
182	R:R:H225	R:R:P226	4.58	No	Yes	0	2	4
183	R:R:P226	R:R:W228	5.4	Yes	No	17	4	1
184	R:R:P226	R:R:Y229	2.78	Yes	Yes	17	4	1
185	R:R:P226	R:R:W230	2.7	Yes	Yes	17	4	1
186	R:R:W228	R:R:Y229	4.82	No	Yes	17	1	1
187	R:R:W230	R:R:Y229	12.54	Yes	Yes	17	1	1
188	R:R:L233	R:R:Y229	5.86	No	Yes	0	3	1
189	R:R:E231	R:R:K235	4.05	No	Yes	0	4	4
190	R:R:K235	R:R:N232	2.8	Yes	No	0	4	2
191	R:R:K235	R:R:V302	4.55	Yes	No	0	4	5
192	R:R:A306	R:R:K235	3.21	No	Yes	0	4	4
193	R:R:I236	R:R:I240	2.94	No	No	0	4	5
194	R:R:C237	R:R:F241	4.19	No	No	0	5	4
195	L:L:?1	R:R:V238	2.89	Yes	No	0	0	5
196	R:R:F239	R:R:I244	8.79	No	No	0	6	4
197	R:R:F239	R:R:H299	3.39	No	Yes	0	6	7
198	R:R:F239	R:R:I303	7.54	No	No	0	6	5
199	R:R:F241	R:R:I240	3.77	No	No	0	4	5
200	R:R:F243	R:R:I244	3.77	Yes	No	0	8	4
201	R:R:F243	R:R:V247	2.62	Yes	No	0	8	6
202	R:R:F243	R:R:T296	7.78	Yes	Yes	0	8	5
203	R:R:F243	R:R:H299	18.1	Yes	Yes	0	8	7
204	R:R:M245	R:R:P246	5.03	No	Yes	0	5	8
205	R:R:I249	R:R:M245	2.92	No	No	0	6	5
206	R:R:F291	R:R:P246	2.89	Yes	Yes	3	9	8
207	R:R:F291	R:R:V247	2.62	Yes	No	0	9	6
208	R:R:I250	R:R:Y254	3.63	No	Yes	3	8	9
209	R:R:F291	R:R:I250	5.02	Yes	No	3	9	8
210	R:R:L256	R:R:V252	2.98	No	No	0	5	4
211	R:R:V284	R:R:Y254	5.05	No	Yes	0	8	9
212	R:R:V287	R:R:Y254	3.79	No	Yes	3	8	9
213	R:R:V288	R:R:Y254	3.79	No	Yes	0	8	9
214	R:R:L261	R:R:M257	4.24	Yes	No	10	8	8
215	R:R:I258	R:R:V284	4.61	No	No	0	5	8
216	R:R:R260	R:R:S263	2.64	Yes	No	0	5	3
217	A:A:I344	R:R:R260	3.76	Yes	Yes	0	6	5
218	R:R:L261	R:R:L267	4.15	Yes	Yes	0	8	1
219	A:A:L348	R:R:L261	2.77	Yes	Yes	10	9	8
220	A:A:Y320	R:R:R265	11.32	Yes	No	0	7	3
221	R:R:L267	R:R:M266	2.83	Yes	No	0	1	4
222	A:A:E318	R:R:M266	8.12	No	No	0	4	4
223	A:A:K345	R:R:M266	10.08	No	No	0	5	4
224	R:R:L267	R:R:L277	8.3	Yes	No	0	1	6
225	A:A:F354	R:R:L267	2.44	Yes	Yes	0	5	1
226	R:R:D274	R:R:G269	3.35	No	No	0	1	1
227	R:R:K273	R:R:S270	7.65	No	No	0	3	2
228	R:R:E272	R:R:R275	10.47	No	No	0	3	4
229	A:A:D315	R:R:E272	9.09	No	No	0	3	3
230	A:A:E318	R:R:K273	6.75	No	No	0	4	3
231	R:R:N276	R:R:R279	12.05	No	Yes	10	5	7
232	R:R:I280	R:R:N276	2.83	No	No	10	8	5
233	A:A:F354	R:R:N276	12.08	Yes	No	10	5	5
234	R:R:L277	R:R:T281	2.95	No	No	0	6	6
235	R:R:E343	R:R:R279	4.65	No	Yes	10	5	7
236	A:A:F354	R:R:R279	3.21	Yes	Yes	10	5	7
237	A:A:F354	R:R:I280	3.77	Yes	No	10	5	8
238	R:R:L341	R:R:M283	7.07	No	No	0	7	8
239	R:R:L337	R:R:V286	2.98	Yes	No	0	8	6
240	R:R:L337	R:R:V287	5.96	Yes	No	3	8	8
241	R:R:V287	R:R:Y338	7.57	No	Yes	3	8	9
242	R:R:N330	R:R:V290	2.96	Yes	No	0	9	7
243	R:R:L333	R:R:V290	4.47	No	No	0	6	7
244	R:R:L337	R:R:V290	4.47	Yes	No	0	8	7
245	R:R:F291	R:R:W295	7.02	Yes	Yes	3	9	8
246	R:R:F291	R:R:N330	4.83	Yes	Yes	3	9	9
247	R:R:I292	R:R:T296	3.04	No	Yes	0	6	5
248	R:R:C294	R:R:T329	3.38	No	No	0	9	5
249	R:R:C294	R:R:N330	7.87	No	Yes	0	9	9
250	R:R:H299	R:R:W295	8.46	Yes	Yes	0	7	8
251	R:R:N330	R:R:W295	7.91	Yes	Yes	3	9	8
252	L:L:?1	R:R:W295	5.16	Yes	Yes	3	0	8
253	R:R:P297	R:R:T296	3.5	No	Yes	0	9	5
254	R:R:I300	R:R:T296	3.04	No	Yes	0	6	5
255	R:R:L326	R:R:P297	4.93	No	No	0	8	9
256	R:R:H299	R:R:I298	2.65	Yes	No	0	7	6
257	R:R:C323	R:R:I298	3.27	No	No	0	6	6
258	L:L:?1	R:R:I298	2.77	Yes	No	0	0	6
259	R:R:I300	R:R:I304	2.94	No	No	0	6	5
260	R:R:I310	R:R:Y301	3.63	No	No	25	4	5
261	R:R:Q316	R:R:Y301	4.51	No	No	25	3	5
262	R:R:W320	R:R:Y301	5.79	Yes	No	0	4	5
263	R:R:V302	R:R:W320	2.45	No	Yes	0	5	4
264	R:R:I303	R:R:L307	2.85	No	No	0	5	5
265	R:R:K305	R:R:W320	10.44	No	Yes	0	3	4
266	R:R:I310	R:R:Q316	9.61	No	No	25	4	3
267	R:R:E312	R:R:T317	2.82	No	No	0	2	4
268	R:R:H321	R:R:W320	5.29	Yes	Yes	0	4	4
269	R:R:I324	R:R:W320	7.05	No	Yes	0	5	4
270	L:L:?1	R:R:I324	5.54	Yes	No	0	0	5
271	R:R:L326	R:R:T329	2.95	No	No	0	8	5
272	L:L:?1	R:R:Y328	12.89	Yes	Yes	3	0	7
273	R:R:N330	R:R:N334	8.17	Yes	Yes	3	9	9
274	R:R:N334	R:R:S331	2.98	Yes	No	3	9	9
275	R:R:L333	R:R:V336	2.98	No	No	0	6	6
276	R:R:N334	R:R:Y338	6.98	Yes	Yes	3	9	9
277	R:R:F340	R:R:V336	5.24	Yes	No	0	6	6
278	R:R:L337	R:R:Y338	3.52	Yes	Yes	3	8	9
279	R:R:F340	R:R:F349	5.36	Yes	No	0	6	6
280	R:R:D342	R:R:F345	5.97	No	Yes	21	8	8
281	A:A:G352	R:R:D342	5.03	No	No	0	8	8
282	A:A:F354	R:R:E343	3.5	Yes	No	10	5	5
283	A:A:L5	A:A:T4	2.95	Yes	No	0	2	4
284	A:A:D9	A:A:L5	2.71	No	Yes	0	4	2
285	A:A:K10	A:A:L5	2.82	No	Yes	0	3	2
286	A:A:D9	A:A:S6	8.83	No	No	0	4	7
287	A:A:V13	B:B:N88	10.35	No	Yes	0	3	7
288	A:A:S16	B:B:N88	7.45	No	Yes	0	7	7
289	A:A:S16	B:B:K89	4.59	No	Yes	0	7	9
290	A:A:I19	A:A:L23	2.85	Yes	No	7	9	6
291	A:A:I19	B:B:K89	5.82	Yes	Yes	7	9	9
292	A:A:D20	B:B:K89	8.3	No	Yes	0	6	9
293	A:A:N22	A:A:R21	3.62	No	No	0	4	4
294	A:A:L23	B:B:K78	5.64	No	No	0	6	8
295	A:A:L23	B:B:K89	2.82	No	Yes	7	6	9
296	A:A:D26	B:B:K78	5.53	No	No	0	5	8
297	A:A:K29	A:A:R32	2.48	No	No	0	1	4
298	A:A:E33	A:A:K29	4.05	Yes	No	0	6	1
299	A:A:E33	A:A:H195	3.69	Yes	No	0	6	4
300	A:A:E33	A:A:K197	8.1	Yes	Yes	0	6	6
301	A:A:L36	A:A:V34	2.98	Yes	Yes	4	7	5
302	A:A:L194	A:A:V34	4.47	Yes	Yes	4	4	5
303	A:A:F196	A:A:V34	5.24	Yes	Yes	4	7	5
304	A:A:T219	A:A:V34	4.76	No	Yes	4	7	5
305	A:A:V339	A:A:V34	6.41	No	Yes	4	8	5
306	A:A:F199	A:A:K35	3.72	Yes	No	0	5	9
307	A:A:F196	A:A:L36	3.65	Yes	Yes	4	7	7
308	A:A:L36	A:A:T219	2.95	Yes	No	4	7	7
309	A:A:I222	A:A:L36	4.28	Yes	Yes	4	7	7
310	A:A:L37	A:A:L39	5.54	No	Yes	2	9	9
311	A:A:F215	A:A:L37	9.74	Yes	No	2	9	9
312	A:A:I221	A:A:L37	2.85	Yes	No	2	8	9
313	A:A:K46	A:A:L38	7.05	Yes	Yes	4	9	8
314	A:A:L38	A:A:M198	4.24	Yes	No	4	8	7
315	A:A:D200	A:A:L38	9.5	No	Yes	4	9	8
316	A:A:I222	A:A:L38	2.85	Yes	Yes	4	7	8
317	A:A:I221	A:A:L39	2.85	Yes	Yes	2	8	9
318	A:A:F223	A:A:L39	2.44	Yes	Yes	0	9	9
319	A:A:I253	A:A:L39	5.71	Yes	Yes	2	8	9
320	A:A:G40	A:A:K46	3.49	No	Yes	0	9	9
321	A:A:F223	A:A:G40	3.01	Yes	No	0	9	9
322	A:A:E43	A:A:R242	9.3	No	No	0	9	9
323	A:A:S44	A:A:V225	3.23	No	Yes	0	9	7
324	A:A:D200	A:A:K46	8.3	No	Yes	4	9	9
325	A:A:Q52	A:A:T48	2.83	Yes	No	0	9	9
326	A:A:I49	A:A:Q52	2.74	Yes	Yes	0	7	9
327	A:A:I49	A:A:M53	2.92	Yes	Yes	4	7	8
328	A:A:C224	A:A:I49	3.27	No	Yes	4	7	7
329	A:A:F267	A:A:I49	8.79	Yes	Yes	4	9	7
330	A:A:I49	A:A:T324	3.04	Yes	Yes	4	7	9
331	A:A:K54	A:A:V50	6.07	No	No	4	7	6
332	A:A:T187	A:A:V50	4.76	Yes	No	4	6	6
333	A:A:D328	A:A:Q52	9.14	No	Yes	0	9	9
334	A:A:N331	A:A:Q52	7.92	No	Yes	0	8	9
335	A:A:F189	A:A:M53	3.73	Yes	Yes	4	9	8
336	A:A:F267	A:A:M53	2.49	Yes	Yes	4	9	8
337	A:A:M53	A:A:V332	3.04	Yes	No	0	8	7
338	A:A:M53	A:A:V335	3.04	Yes	No	4	8	8
339	A:A:K54	A:A:T187	4.5	No	Yes	4	7	6
340	A:A:G183	B:B:N119	3.39	No	No	0	9	9
341	A:A:F199	A:A:I184	3.77	Yes	Yes	2	5	9
342	A:A:I184	A:A:V201	3.07	Yes	No	2	9	9
343	A:A:I184	A:A:Q204	2.74	Yes	Yes	2	9	9
344	A:A:I184	B:B:L117	4.28	Yes	Yes	2	9	9
345	A:A:E186	A:A:H188	13.54	No	No	2	9	3
346	A:A:E186	A:A:K197	5.4	No	Yes	2	9	6
347	A:A:E186	A:A:F199	12.83	No	Yes	2	9	5
348	A:A:F189	A:A:T187	2.59	Yes	Yes	4	9	6
349	A:A:M198	A:A:T187	3.01	No	Yes	4	7	6
350	A:A:H188	A:A:K197	6.55	No	Yes	2	3	6
351	A:A:F189	A:A:F196	15	Yes	Yes	4	9	7
352	A:A:F189	A:A:M198	2.49	Yes	No	4	9	7
353	A:A:H195	A:A:T190	5.48	No	No	0	4	3
354	A:A:F191	A:A:K192	17.37	Yes	No	4	5	4
355	A:A:F191	A:A:V332	7.87	Yes	No	0	5	7
356	A:A:F191	A:A:Q333	4.68	Yes	No	4	5	5
357	A:A:F191	A:A:F336	7.5	Yes	Yes	4	5	8
358	A:A:K192	A:A:Q333	5.42	No	No	4	4	5
359	A:A:F336	A:A:K192	13.65	Yes	No	4	8	4
360	A:A:F196	A:A:L194	8.53	Yes	Yes	4	7	4
361	A:A:F336	A:A:L194	3.65	Yes	Yes	4	8	4
362	A:A:F196	A:A:V339	3.93	Yes	No	4	7	8
363	A:A:F199	A:A:K197	6.2	Yes	Yes	2	5	6
364	A:A:F199	A:A:F215	3.22	Yes	Yes	2	5	9
365	A:A:F199	B:B:W99	12.03	Yes	Yes	2	5	9
366	A:A:V201	A:A:W211	7.36	No	Yes	2	9	9
367	A:A:F215	A:A:V201	2.62	Yes	No	2	9	9
368	A:A:Q204	A:A:S206	2.89	Yes	Yes	2	9	8
369	A:A:Q204	A:A:W211	9.86	Yes	Yes	2	9	9
370	A:A:Q204	B:B:L117	6.65	Yes	Yes	2	9	9
371	A:A:S206	A:A:W211	4.94	Yes	Yes	2	8	9
372	A:A:S206	B:B:Y145	5.09	Yes	Yes	2	8	8
373	A:A:S206	B:B:D186	2.94	Yes	No	0	8	9
374	A:A:E207	B:B:D186	3.9	No	No	0	9	9
375	A:A:R208	A:A:W211	6	Yes	Yes	2	9	9
376	A:A:I212	A:A:R208	2.51	No	Yes	2	8	9
377	A:A:R208	A:A:S252	5.27	Yes	No	2	9	7
378	A:A:I253	A:A:R208	10.02	Yes	Yes	2	8	9
379	A:A:K210	B:B:Y145	3.58	No	Yes	2	9	8
380	A:A:K210	B:B:C204	6.47	No	No	2	9	7
381	A:A:K210	B:B:D228	8.3	No	No	2	9	9
382	A:A:F215	A:A:W211	4.01	Yes	Yes	2	9	9
383	A:A:W211	B:B:L117	4.56	Yes	Yes	2	9	9
384	A:A:W211	B:B:Y145	6.75	Yes	Yes	2	9	8
385	A:A:I212	A:A:N256	4.25	No	Yes	2	8	8
386	A:A:F259	A:A:I212	5.02	Yes	No	2	9	8
387	A:A:C214	A:A:H213	2.95	No	Yes	2	7	8
388	A:A:H213	A:A:W258	9.52	Yes	Yes	2	8	5
389	A:A:H213	B:B:Y59	4.36	Yes	Yes	2	8	8
390	A:A:H213	B:B:W332	5.29	Yes	Yes	2	8	9
391	A:A:C214	B:B:Y59	5.38	No	Yes	2	7	8
392	A:A:C214	B:B:W99	2.61	No	Yes	2	7	9
393	A:A:F215	B:B:W99	10.02	Yes	Yes	2	9	9
394	A:A:F215	B:B:L117	2.44	Yes	Yes	2	9	9
395	A:A:E216	A:A:W258	10.9	No	Yes	0	7	5
396	A:A:E216	B:B:K57	6.75	No	Yes	0	7	9
397	A:A:F259	A:A:V218	2.62	Yes	No	2	9	9
398	A:A:T262	A:A:V218	3.17	No	No	2	7	9
399	A:A:A220	A:A:I265	3.25	No	Yes	0	8	8
400	A:A:I221	A:A:I253	2.94	Yes	Yes	2	8	8
401	A:A:F259	A:A:I221	10.05	Yes	Yes	2	9	8
402	A:A:I221	A:A:T262	3.04	Yes	No	2	8	7
403	A:A:I222	A:A:I265	2.94	Yes	Yes	4	7	8
404	A:A:F267	A:A:I222	2.51	Yes	Yes	4	9	7
405	A:A:F223	A:A:V225	3.93	Yes	Yes	0	9	7
406	A:A:F223	A:A:L249	7.31	Yes	No	0	9	9
407	A:A:F223	A:A:F250	10.72	Yes	Yes	0	9	9
408	A:A:F223	A:A:L266	3.65	Yes	Yes	0	9	9
409	A:A:C224	A:A:F267	5.59	No	Yes	4	7	9
410	A:A:S246	A:A:V225	4.85	No	Yes	0	9	7
411	A:A:F307	A:A:V225	2.62	Yes	Yes	0	8	7
412	A:A:A226	A:A:D229	4.63	No	No	0	8	8
413	A:A:A226	A:A:K270	3.21	No	Yes	0	8	9
414	A:A:L227	A:A:L268	9.69	Yes	Yes	12	7	8
415	A:A:F274	A:A:L227	8.53	Yes	Yes	12	9	7
416	A:A:I303	A:A:L227	2.85	No	Yes	12	7	7
417	A:A:F323	A:A:L227	2.44	Yes	Yes	12	4	7
418	A:A:K270	A:A:S228	4.59	Yes	No	0	9	9
419	A:A:K277	A:A:S228	4.59	No	No	0	9	9
420	A:A:D229	A:A:R242	22.63	No	No	0	8	9
421	A:A:D229	A:A:M243	2.77	No	No	0	8	8
422	A:A:F274	A:A:Y230	6.19	Yes	Yes	0	9	8
423	A:A:K277	A:A:Y230	9.55	No	Yes	0	9	8
424	A:A:I278	A:A:Y230	4.84	No	Yes	0	6	8
425	A:A:L283	A:A:Y230	5.86	No	Yes	0	7	8
426	A:A:D231	A:A:K277	9.68	No	No	0	9	9
427	A:A:E236	A:A:L234	3.98	No	No	18	9	8
428	A:A:E238	A:A:L234	2.65	No	No	18	4	8
429	A:A:L234	A:A:M240	2.83	No	No	0	8	6
430	A:A:D237	A:A:E236	2.6	No	No	18	8	9
431	A:A:E236	A:A:E238	2.54	No	No	18	9	4
432	A:A:D237	A:A:E238	2.6	No	No	18	8	4
433	A:A:E245	A:A:M240	4.06	No	No	0	9	6
434	A:A:H244	A:A:N241	6.38	No	No	0	4	9
435	A:A:C286	A:A:N241	3.15	No	No	0	6	9
436	A:A:M243	A:A:S246	3.07	No	No	0	8	9
437	A:A:F307	A:A:M243	2.49	Yes	No	0	8	8
438	A:A:H244	A:A:Y287	6.53	No	Yes	0	4	7
439	A:A:F307	A:A:M247	3.73	Yes	No	0	8	6
440	A:A:L310	A:A:M247	2.83	No	No	0	4	6
441	A:A:C254	A:A:F250	2.79	Yes	Yes	16	5	9
442	A:A:F250	A:A:I264	6.28	Yes	No	16	9	6
443	A:A:F250	A:A:L310	7.31	Yes	No	0	9	4
444	A:A:F250	A:A:I319	3.77	Yes	No	0	9	5
445	A:A:D251	A:A:N255	8.08	No	No	0	5	8
446	A:A:I253	A:A:S252	3.1	Yes	No	2	8	7
447	A:A:C254	A:A:I264	3.27	Yes	No	16	5	6
448	A:A:C254	A:A:N311	4.72	Yes	Yes	16	5	8
449	A:A:C254	A:A:K317	6.47	Yes	No	16	5	7
450	A:A:K312	A:A:N255	18.19	No	No	0	5	8
451	A:A:K257	A:A:N256	2.8	No	Yes	2	4	8
452	A:A:N256	A:A:W258	6.78	Yes	Yes	2	8	5
453	A:A:F259	A:A:N256	4.83	Yes	Yes	2	9	8
454	A:A:K257	A:A:W258	8.12	No	Yes	2	4	5
455	A:A:W258	B:B:W332	3.75	Yes	Yes	2	5	9
456	A:A:F259	A:A:T262	5.19	Yes	No	2	9	7
457	A:A:D261	A:A:T260	4.34	No	No	0	4	3
458	A:A:R313	A:A:T260	3.88	No	No	0	4	3
459	A:A:D261	A:A:K349	4.15	No	No	0	4	5
460	A:A:S263	A:A:Y320	5.09	No	Yes	0	7	7
461	A:A:S263	A:A:V342	3.23	No	No	0	7	7
462	A:A:F267	A:A:I265	3.77	Yes	Yes	4	9	8
463	A:A:I265	A:A:Y320	3.63	Yes	Yes	4	8	7
464	A:A:F334	A:A:I265	2.51	No	Yes	0	3	8
465	A:A:A338	A:A:I265	3.25	No	Yes	4	6	8
466	A:A:L266	A:A:L268	4.15	Yes	Yes	12	9	8
467	A:A:F307	A:A:L266	4.87	Yes	Yes	12	8	9
468	A:A:L266	A:A:T321	10.32	Yes	No	12	9	5
469	A:A:F267	A:A:H322	3.39	Yes	No	0	9	9
470	A:A:F267	A:A:T324	3.89	Yes	Yes	4	9	9
471	A:A:F267	A:A:V335	2.62	Yes	No	4	9	8
472	A:A:F307	A:A:L268	2.44	Yes	Yes	12	8	8
473	A:A:L268	A:A:T321	2.95	Yes	No	12	8	5
474	A:A:F323	A:A:L268	6.09	Yes	Yes	12	4	8
475	A:A:N269	A:A:T324	7.31	No	Yes	0	9	9
476	A:A:K270	A:A:L273	5.64	Yes	No	0	9	6
477	A:A:K271	A:A:Y296	5.97	No	No	0	5	4
478	A:A:F323	A:A:K271	2.48	Yes	No	0	4	5
479	A:A:C325	A:A:K271	3.23	No	No	0	7	5
480	A:A:D272	A:A:L273	2.71	No	No	0	9	6
481	A:A:F274	A:A:Y296	4.13	Yes	No	0	9	4
482	A:A:A299	A:A:F274	2.77	No	Yes	0	7	9
483	A:A:F274	A:A:I303	2.51	Yes	No	12	9	7
484	A:A:E275	A:A:Y296	11.22	No	No	0	5	4
485	A:A:I278	A:A:N294	7.08	No	No	0	6	3
486	A:A:A299	A:A:I278	3.25	No	No	0	7	6
487	A:A:P282	A:A:S281	3.56	No	No	0	5	7
488	A:A:P282	A:A:T284	3.5	No	No	0	5	4
489	A:A:L283	A:A:Y290	9.38	No	Yes	0	7	7
490	A:A:C286	A:A:Y287	5.38	No	Yes	0	6	7
491	A:A:Y287	A:A:Y290	3.97	Yes	Yes	14	7	7
492	A:A:Y287	A:A:Y302	3.97	Yes	Yes	14	7	6
493	A:A:G292	A:A:Y290	5.79	No	Yes	0	7	7
494	A:A:Y290	A:A:Y302	14.89	Yes	Yes	14	7	6
495	A:A:S293	A:A:T295	3.2	No	No	14	3	5
496	A:A:E298	A:A:S293	5.75	No	No	14	4	3
497	A:A:E298	A:A:T295	12.7	No	No	14	4	5
498	A:A:A300	A:A:F323	2.77	No	Yes	0	5	4
499	A:A:Q306	A:A:Y302	12.4	No	Yes	0	5	6
500	A:A:F307	A:A:I303	3.77	Yes	No	12	8	7
501	A:A:E308	A:A:Q304	2.55	No	No	0	3	5
502	A:A:Q304	A:A:T321	11.34	No	No	0	5	5
503	A:A:D309	A:A:Q306	2.61	No	No	0	4	5
504	A:A:K314	A:A:N311	2.8	No	Yes	0	3	8
505	A:A:K317	A:A:N311	6.99	No	Yes	16	7	8
506	A:A:I319	A:A:N311	5.66	No	Yes	0	5	8
507	A:A:R313	A:A:T316	16.82	No	No	0	4	3
508	A:A:E318	A:A:Y320	5.61	No	Yes	0	4	7
509	A:A:A338	A:A:Y320	9.34	No	Yes	4	6	7
510	A:A:D341	A:A:Y320	6.9	No	Yes	0	8	7
511	A:A:H322	A:A:N331	2.55	No	No	0	9	8
512	A:A:F334	A:A:H322	20.36	No	No	0	3	9
513	A:A:N331	A:A:T324	7.31	No	Yes	0	8	9
514	A:A:C325	A:A:T327	3.38	No	No	0	7	8
515	A:A:C325	A:A:K330	3.23	No	No	0	7	4
516	A:A:F336	A:A:T340	7.78	Yes	No	0	8	6
517	A:A:I343	A:A:V339	3.07	No	No	0	7	8
518	A:A:N346	A:A:V342	2.96	No	No	0	4	7
519	A:A:I344	A:A:L348	2.85	Yes	Yes	0	6	9
520	A:A:K345	A:A:K349	7.18	No	No	0	5	5
521	A:A:L348	A:A:L353	2.77	Yes	No	0	9	7
522	A:A:F354	A:A:L348	2.44	Yes	Yes	10	5	9
523	A:A:F354	A:A:K349	3.72	Yes	No	0	5	5
524	A:A:C351	A:A:L353	3.17	No	No	0	4	7
525	B:B:D5	B:B:R8	4.76	No	No	0	1	3
526	B:B:L7	B:B:Q6	2.66	No	No	0	8	1
527	B:B:L7	G:G:I9	2.85	No	No	0	8	2
528	B:B:L7	G:G:A12	3.15	No	No	0	8	5
529	B:B:E10	B:B:L14	3.98	No	Yes	26	8	8
530	B:B:E10	G:G:K20	2.7	No	No	26	8	6
531	B:B:L14	B:B:Q13	2.66	Yes	No	0	8	1
532	B:B:L14	G:G:L19	4.15	Yes	No	0	8	9
533	B:B:L14	G:G:K20	2.82	Yes	No	26	8	6
534	B:B:I18	B:B:R22	6.26	No	Yes	0	7	6
535	B:B:I18	G:G:L19	2.85	No	No	0	7	9
536	B:B:I18	G:G:A23	3.25	No	No	0	7	8
537	B:B:D258	B:B:R22	3.57	Yes	Yes	5	7	6
538	B:B:R22	G:G:R27	5.33	Yes	No	5	6	8
539	B:B:A26	B:B:Q259	4.55	No	No	0	3	6
540	B:B:A28	B:B:D27	3.09	No	Yes	0	4	8
541	B:B:D27	G:G:K29	13.83	Yes	No	27	8	4
542	B:B:D27	G:G:V30	2.92	Yes	No	0	8	8
543	B:B:D27	G:G:S31	5.89	Yes	No	27	8	9
544	B:B:A28	B:B:I33	3.25	No	No	0	4	3
545	B:B:S31	B:B:T29	4.8	No	No	0	1	3
546	B:B:Q32	B:B:T29	11.34	No	No	0	1	3
547	B:B:L30	B:B:T34	2.95	No	No	0	5	5
548	B:B:L261	B:B:L30	4.15	No	No	0	5	5
549	B:B:L30	B:B:M262	7.07	No	Yes	0	5	4
550	B:B:I33	G:G:M38	2.92	No	No	0	3	4
551	B:B:L300	B:B:T34	4.42	No	No	0	6	5
552	B:B:I37	B:B:L300	4.28	No	No	0	2	6
553	B:B:I37	G:G:E42	5.47	No	No	0	2	1
554	B:B:K301	B:B:P39	8.36	Yes	No	0	5	1
555	B:B:R283	B:B:V40	3.92	Yes	No	1	9	3
556	B:B:D298	B:B:V40	10.22	No	No	1	9	3
557	B:B:I43	B:B:M45	2.92	No	Yes	0	3	4
558	B:B:A305	B:B:I43	3.25	No	No	0	4	3
559	B:B:L308	B:B:M45	4.24	Yes	Yes	0	7	4
560	B:B:M45	B:B:N340	4.21	Yes	Yes	1	4	9
561	B:B:M45	G:G:L50	7.07	Yes	Yes	1	4	9
562	B:B:R46	B:B:R48	6.4	No	Yes	1	5	7
563	B:B:R46	G:G:E63	10.47	No	No	1	5	6
564	B:B:T47	B:B:W339	8.49	No	No	0	3	9
565	B:B:N340	B:B:R48	12.05	Yes	Yes	1	9	7
566	B:B:R48	G:G:N59	4.82	Yes	Yes	1	7	9
567	B:B:R48	G:G:F61	4.28	Yes	Yes	1	7	8
568	B:B:R48	G:G:E63	3.49	Yes	No	1	7	6
569	B:B:R49	B:B:T87	2.59	No	No	0	7	5
570	B:B:I338	B:B:R49	5.01	No	No	1	5	7
571	B:B:R49	G:G:F61	5.34	No	Yes	1	7	8
572	B:B:R52	B:B:T50	10.35	No	No	0	7	3
573	B:B:K337	B:B:T50	3	No	No	0	6	3
574	B:B:L51	B:B:W82	23.92	No	Yes	7	9	9
575	B:B:L336	B:B:L51	8.3	Yes	No	7	7	9
576	B:B:F335	B:B:R52	8.55	No	No	0	4	7
577	B:B:G53	B:B:K89	3.49	No	Yes	0	9	9
578	B:B:H54	B:B:I58	11.93	Yes	No	7	9	9
579	B:B:H54	B:B:S72	8.37	Yes	Yes	7	9	9
580	B:B:H54	B:B:S74	8.37	Yes	No	0	9	9
581	B:B:H54	B:B:I80	9.28	Yes	No	7	9	8
582	B:B:H54	B:B:W82	8.46	Yes	Yes	7	9	9
583	B:B:H54	B:B:L336	6.43	Yes	Yes	7	9	7
584	B:B:A56	B:B:D76	3.09	No	No	0	7	9
585	B:B:K57	B:B:Y59	8.36	Yes	Yes	2	9	8
586	B:B:K57	B:B:Q75	2.71	Yes	Yes	2	9	9
587	B:B:K57	B:B:W332	20.89	Yes	Yes	2	9	9
588	B:B:I58	B:B:S72	4.64	No	Yes	7	9	9
589	B:B:I58	B:B:L336	4.28	No	Yes	7	9	7
590	B:B:Q75	B:B:Y59	7.89	Yes	Yes	2	9	8
591	B:B:W332	B:B:Y59	6.75	Yes	Yes	2	9	8
592	B:B:M61	B:B:W63	5.82	No	Yes	1	6	7
593	B:B:C317	B:B:M61	3.24	No	No	0	7	6
594	B:B:G319	B:B:M61	3.49	No	No	1	5	6
595	B:B:H62	B:B:Y105	4.36	No	Yes	0	6	6
596	B:B:H62	B:B:R150	6.77	No	No	0	6	6
597	B:B:G319	B:B:W63	2.81	No	Yes	1	5	7
598	B:B:T321	B:B:W63	15.77	No	Yes	1	7	7
599	B:B:A326	B:B:W63	2.59	No	Yes	0	7	7
600	B:B:A328	B:B:W63	5.19	No	Yes	0	5	7
601	B:B:G64	B:B:Y105	4.35	No	Yes	0	5	6
602	B:B:D322	B:B:T65	2.89	No	No	0	1	1
603	B:B:D66	B:B:L69	9.5	No	No	0	8	5
604	B:B:S67	B:B:T321	4.8	No	No	1	5	7
605	B:B:D323	B:B:S67	10.31	No	No	1	7	5
606	B:B:D83	B:B:R68	14.29	No	Yes	1	8	5
607	B:B:R68	B:B:S84	2.64	Yes	No	1	5	5
608	B:B:R68	B:B:Y85	18.52	Yes	Yes	1	5	4
609	B:B:R68	B:B:T86	3.88	Yes	No	1	5	6
610	B:B:L69	B:B:Y105	5.86	No	Yes	0	5	6
611	B:B:L70	B:B:W82	3.42	No	Yes	0	5	9
612	B:B:I81	B:B:V71	3.07	Yes	No	0	7	8
613	B:B:C103	B:B:V71	3.42	No	No	0	8	8
614	B:B:S72	B:B:W82	2.47	Yes	Yes	7	9	9
615	B:B:L336	B:B:S72	6.01	Yes	Yes	7	7	9
616	B:B:A73	B:B:C103	3.61	No	No	0	9	8
617	B:B:D76	B:B:S74	7.36	No	No	0	9	9
618	B:B:Q75	B:B:W99	7.67	Yes	Yes	2	9	9
619	B:B:D76	B:B:K78	8.3	No	No	0	9	8
620	B:B:G77	B:B:L95	5.13	No	No	0	8	8
621	B:B:I93	B:B:L79	9.99	Yes	No	0	7	7
622	B:B:L79	B:B:L95	6.92	No	No	0	7	8
623	B:B:C114	B:B:L79	6.35	No	No	0	8	7
624	B:B:I80	B:B:W82	14.09	No	Yes	7	8	9
625	B:B:I80	B:B:K89	7.27	No	Yes	7	8	9
626	B:B:I81	B:B:V90	3.07	Yes	No	8	7	5
627	B:B:H91	B:B:I81	9.28	Yes	Yes	8	5	7
628	B:B:I81	B:B:L126	4.28	Yes	Yes	8	7	5
629	B:B:K89	B:B:W82	11.6	Yes	Yes	7	9	9
630	B:B:L336	B:B:W82	4.56	Yes	Yes	7	7	9
631	B:B:D83	B:B:T86	10.12	No	No	1	8	6
632	B:B:S84	B:B:Y85	3.82	No	Yes	1	5	4
633	B:B:S84	G:G:F61	5.28	No	Yes	1	5	8
634	B:B:Y85	G:G:P60	11.13	Yes	Yes	1	4	9
635	B:B:Y85	G:G:F61	8.25	Yes	Yes	1	4	8
636	B:B:N88	B:B:T86	7.31	Yes	No	0	7	6
637	B:B:H91	B:B:V90	5.54	Yes	No	8	5	5
638	B:B:H91	B:B:L126	3.86	Yes	Yes	8	5	5
639	B:B:H91	B:B:V133	4.15	Yes	Yes	8	5	4
640	B:B:I93	B:B:P94	3.39	Yes	No	0	7	5
641	B:B:I93	B:B:Y124	10.88	Yes	Yes	8	7	6
642	B:B:I93	B:B:V133	4.61	Yes	Yes	8	7	4
643	B:B:L95	B:B:Y124	3.52	No	Yes	0	8	6
644	B:B:R96	B:B:V135	10.46	No	No	8	6	4
645	B:B:E138	B:B:R96	9.3	No	No	8	6	6
646	B:B:D118	B:B:S97	8.83	No	No	0	9	8
647	B:B:L117	B:B:W99	6.83	Yes	Yes	2	9	9
648	B:B:G116	B:B:M101	3.49	No	No	0	9	9
649	B:B:M101	B:B:Y145	4.79	No	Yes	0	9	8
650	B:B:C148	B:B:T102	3.38	Yes	No	0	6	8
651	B:B:C149	B:B:T102	3.38	No	No	0	8	8
652	B:B:A104	B:B:F151	2.77	No	Yes	0	7	9
653	B:B:G109	B:B:Y105	5.79	No	Yes	0	5	6
654	B:B:V112	B:B:Y105	2.52	No	Yes	0	8	6
655	B:B:A106	B:B:F151	4.16	No	Yes	0	6	9
656	B:B:N110	B:B:S108	8.94	Yes	No	11	4	6
657	B:B:D154	B:B:S108	8.83	No	No	11	6	6
658	B:B:N110	B:B:Y111	3.49	Yes	Yes	11	4	4
659	B:B:K127	B:B:N110	6.99	No	Yes	0	4	4
660	B:B:D154	B:B:N110	4.04	No	Yes	11	6	4
661	B:B:I123	B:B:Y111	4.84	Yes	Yes	11	6	4
662	B:B:N125	B:B:Y111	11.63	No	Yes	0	4	4
663	B:B:S136	B:B:Y111	2.54	No	Yes	11	4	4
664	B:B:L126	B:B:V112	4.47	Yes	No	0	5	8
665	B:B:A113	B:B:F151	2.77	No	Yes	0	9	9
666	B:B:C114	B:B:Y124	5.38	No	Yes	0	8	6
667	B:B:D118	B:B:I120	4.2	No	No	0	9	6
668	B:B:E138	B:B:I120	2.73	No	No	0	6	6
669	B:B:C121	B:B:L139	6.35	No	No	0	8	9
670	B:B:C121	B:B:L146	3.17	No	No	0	8	7
671	B:B:S122	B:B:Y124	6.36	No	Yes	0	8	6
672	B:B:I123	B:B:S136	3.1	Yes	No	11	6	4
673	B:B:I123	B:B:R137	2.51	Yes	No	0	6	5
674	B:B:F151	B:B:I123	3.77	Yes	Yes	11	9	6
675	B:B:I123	B:B:I171	2.94	Yes	No	11	6	6
676	B:B:V133	B:B:Y124	3.79	Yes	Yes	8	4	6
677	B:B:V135	B:B:Y124	6.31	No	Yes	8	4	6
678	B:B:L126	B:B:V133	4.47	Yes	Yes	8	5	4
679	B:B:E130	B:B:T128	2.82	No	Yes	0	3	3
680	B:B:R134	B:B:T128	2.59	No	Yes	0	3	3
681	B:B:E130	B:B:N132	9.2	No	No	0	3	3
682	B:B:E138	B:B:V135	4.28	No	No	8	6	4
683	B:B:G174	B:B:R137	3	No	No	0	4	5
684	B:B:L139	B:B:W169	13.67	No	Yes	0	9	8
685	B:B:H142	B:B:L146	10.29	Yes	No	15	9	7
686	B:B:H142	B:B:T159	6.85	Yes	Yes	15	9	9
687	B:B:H142	B:B:S161	9.76	Yes	No	0	9	9
688	B:B:H142	B:B:W169	12.7	Yes	Yes	15	9	8
689	B:B:D163	B:B:T143	7.23	Yes	No	0	9	5
690	B:B:D163	B:B:G144	5.03	Yes	No	0	9	8
691	B:B:G162	B:B:Y145	2.9	No	Yes	0	9	8
692	B:B:M188	B:B:Y145	3.59	Yes	Yes	0	8	8
693	B:B:L146	B:B:T159	4.42	No	Yes	15	7	9
694	B:B:M188	B:B:S147	4.6	Yes	No	0	8	9
695	B:B:C148	B:B:R150	6.96	Yes	No	0	6	6
696	B:B:C148	B:B:S160	3.44	Yes	No	6	6	6
697	B:B:C148	B:B:L190	6.35	Yes	No	6	6	5
698	B:B:C149	B:B:I157	3.27	No	No	0	8	7
699	B:B:C149	B:B:T159	3.38	No	Yes	0	8	9
700	B:B:L192	B:B:R150	3.64	No	No	0	5	6
701	B:B:F151	B:B:I157	8.79	Yes	No	11	9	7
702	B:B:F151	B:B:I171	2.51	Yes	No	11	9	6
703	B:B:L152	B:B:V158	2.98	No	Yes	0	3	5
704	B:B:L152	B:B:L192	8.3	No	No	0	3	5
705	B:B:L152	B:B:V213	2.98	No	No	0	3	4
706	B:B:D153	B:B:D154	3.99	No	No	0	5	6
707	B:B:D170	B:B:N155	9.42	No	No	0	9	3
708	B:B:E172	B:B:N155	7.89	No	No	0	6	3
709	B:B:L168	B:B:Q156	2.66	Yes	No	0	6	5
710	B:B:I157	B:B:I171	4.42	No	No	11	7	6
711	B:B:L168	B:B:V158	2.98	Yes	Yes	0	6	5
712	B:B:L190	B:B:V158	2.98	No	Yes	0	5	5
713	B:B:F199	B:B:V158	7.87	Yes	Yes	0	9	5
714	B:B:T159	B:B:W169	8.49	Yes	Yes	15	9	8
715	B:B:S160	B:B:V187	4.85	No	Yes	6	6	9
716	B:B:L190	B:B:S160	3	No	No	6	5	6
717	B:B:G162	B:B:S161	3.71	No	No	0	9	9
718	B:B:D163	B:B:S161	8.83	Yes	No	0	9	9
719	B:B:D186	B:B:G162	5.03	No	No	0	9	9
720	B:B:D163	B:B:T165	8.67	Yes	No	0	9	7
721	B:B:C166	B:B:F180	4.19	No	Yes	6	8	7
722	B:B:C166	B:B:V187	5.12	No	Yes	6	8	9
723	B:B:C166	B:B:S201	3.44	No	Yes	6	8	9
724	B:B:A167	B:B:W169	5.19	No	Yes	15	4	8
725	B:B:A167	B:B:Q176	4.55	No	No	15	4	4
726	B:B:L168	B:B:T177	4.42	Yes	No	6	6	4
727	B:B:L168	B:B:T178	4.42	Yes	No	6	6	4
728	B:B:Q176	B:B:W169	14.24	No	Yes	15	4	8
729	B:B:D170	B:B:T173	10.12	No	No	0	9	5
730	B:B:Q175	B:B:T173	5.67	No	No	0	4	5
731	B:B:Q176	B:B:T179	5.67	No	No	0	4	4
732	B:B:T177	B:B:T178	4.71	No	No	6	4	4
733	B:B:F180	B:B:T178	6.49	Yes	No	6	7	4
734	B:B:F180	B:B:F199	5.36	Yes	Yes	6	7	9
735	B:B:F180	B:B:W211	12.03	Yes	Yes	6	7	8
736	B:B:F180	B:B:G216	3.01	Yes	No	0	7	4
737	B:B:H183	B:B:V187	8.3	Yes	Yes	6	9	9
738	B:B:H183	B:B:S201	2.79	Yes	Yes	6	9	9
739	B:B:A203	B:B:H183	4.39	No	Yes	6	8	9
740	B:B:H183	B:B:K209	5.24	Yes	Yes	6	9	6
741	B:B:H183	B:B:W211	12.7	Yes	Yes	6	9	8
742	B:B:D205	B:B:T184	7.23	Yes	No	0	9	3
743	B:B:D205	B:B:G185	3.35	Yes	No	0	9	5
744	B:B:S201	B:B:V187	3.23	Yes	Yes	6	9	9
745	B:B:A203	B:B:V187	3.39	No	Yes	6	8	9
746	B:B:C204	B:B:M188	3.24	No	Yes	0	7	8
747	B:B:M188	B:B:N230	2.8	Yes	No	0	8	9
748	B:B:I232	B:B:S189	4.64	Yes	No	0	8	7
749	B:B:F234	B:B:S191	5.28	Yes	No	0	5	8
750	B:B:A193	B:B:D195	3.09	No	No	0	4	5
751	B:B:A193	B:B:F234	8.32	No	Yes	0	4	5
752	B:B:D195	B:B:R197	7.15	No	No	0	5	5
753	B:B:R197	B:B:R214	6.4	No	No	0	5	9
754	B:B:L198	B:B:L210	6.92	No	No	0	3	5
755	B:B:F234	B:B:L198	2.44	Yes	No	0	5	3
756	B:B:F199	B:B:W211	11.02	Yes	Yes	6	9	8
757	B:B:F199	B:B:V213	2.62	Yes	No	0	9	4
758	B:B:I232	B:B:V200	6.14	Yes	No	5	8	6
759	B:B:F234	B:B:V200	7.87	Yes	No	5	5	6
760	B:B:F241	B:B:V200	13.11	Yes	No	5	6	6
761	B:B:S201	B:B:W211	6.18	Yes	Yes	6	9	8
762	B:B:G202	B:B:I229	5.29	No	Yes	0	6	7
763	B:B:A203	B:B:D205	3.09	No	Yes	0	8	9
764	B:B:C204	B:B:D228	3.11	No	No	2	7	9
765	B:B:D205	B:B:S207	10.31	Yes	No	0	9	5
766	B:B:K209	B:B:S207	3.06	Yes	No	0	6	5
767	B:B:K209	B:B:W211	4.64	Yes	Yes	6	6	8
768	B:B:C218	B:B:K209	4.85	No	Yes	6	5	6
769	B:B:K209	B:B:T221	13.51	Yes	No	0	6	7
770	B:B:L210	B:B:R219	7.29	No	No	0	5	5
771	B:B:L210	B:B:L255	9.69	No	Yes	0	5	6
772	B:B:C218	B:B:W211	3.92	No	Yes	6	5	8
773	B:B:D212	B:B:E215	16.89	No	No	0	9	3
774	B:B:E215	B:B:M217	2.71	No	No	0	3	3
775	B:B:M217	G:G:M21	4.33	No	No	0	3	1
776	B:B:C218	G:G:Q18	4.58	No	No	0	5	9
777	B:B:F222	B:B:Q220	5.86	Yes	Yes	5	8	7
778	B:B:L255	B:B:Q220	7.99	Yes	Yes	5	6	7
779	B:B:D258	B:B:Q220	15.66	Yes	Yes	5	7	7
780	B:B:Q220	G:G:I25	4.12	Yes	No	0	7	2
781	B:B:T221	G:G:E22	11.29	No	No	0	7	9
782	B:B:F222	B:B:F241	6.43	Yes	Yes	5	8	6
783	B:B:F222	B:B:F253	18.22	Yes	Yes	5	8	6
784	B:B:F222	B:B:L255	2.44	Yes	Yes	5	8	6
785	B:B:D258	B:B:F222	7.17	Yes	Yes	5	7	8
786	B:B:F253	B:B:G224	3.01	Yes	No	0	6	6
787	B:B:H225	B:B:I229	9.28	Yes	Yes	5	9	7
788	B:B:H225	B:B:T243	9.58	Yes	Yes	5	9	8
789	B:B:H225	B:B:S245	13.95	Yes	No	5	9	9
790	B:B:D247	B:B:H225	3.78	Yes	Yes	5	9	9
791	B:B:H225	B:B:R251	15.8	Yes	Yes	5	9	8
792	B:B:F253	B:B:H225	4.53	Yes	Yes	5	6	9
793	B:B:D247	B:B:E226	7.8	Yes	No	0	9	3
794	B:B:D228	B:B:S227	7.36	No	No	0	9	6
795	B:B:I229	B:B:T243	4.56	Yes	Yes	5	7	8
796	B:B:I229	B:B:S245	3.1	Yes	No	5	7	9
797	B:B:D246	B:B:N230	5.39	No	No	0	9	9
798	B:B:F241	B:B:I232	5.02	Yes	Yes	5	6	8
799	B:B:I232	B:B:T243	7.6	Yes	Yes	5	8	8
800	B:B:C233	B:B:F278	2.79	No	Yes	0	3	7
801	B:B:F234	B:B:F241	3.22	Yes	Yes	5	5	6
802	B:B:F235	B:B:P236	11.56	Yes	Yes	13	6	7
803	B:B:F235	B:B:N237	14.5	Yes	No	0	6	5
804	B:B:F235	B:B:F278	6.43	Yes	Yes	13	6	7
805	B:B:F235	B:B:G282	3.01	Yes	No	13	6	9
806	B:B:F235	G:G:L37	7.31	Yes	No	0	6	7
807	B:B:F235	G:G:Y40	3.09	Yes	No	13	6	6
808	B:B:F235	G:G:C41	2.79	Yes	No	0	6	7
809	B:B:F278	B:B:P236	2.89	Yes	Yes	13	7	7
810	B:B:G282	B:B:P236	4.06	No	Yes	13	9	7
811	B:B:P236	G:G:Y40	4.17	Yes	No	13	7	6
812	B:B:G238	B:B:N237	3.39	No	No	0	7	5
813	B:B:N237	B:B:N239	9.54	No	No	0	5	2
814	B:B:N239	B:B:R256	14.46	No	No	0	2	9
815	B:B:A240	B:B:L252	3.15	No	No	0	6	7
816	B:B:F241	B:B:T243	2.59	Yes	Yes	5	6	8
817	B:B:F241	B:B:F253	7.5	Yes	Yes	5	6	6
818	B:B:F241	B:B:L255	4.87	Yes	Yes	5	6	6
819	B:B:A242	B:B:F278	2.77	No	Yes	13	4	7
820	B:B:A242	B:B:L285	3.15	No	No	13	4	6
821	B:B:F253	B:B:T243	3.89	Yes	Yes	5	6	8
822	B:B:G244	B:B:I273	3.53	No	No	0	5	6
823	B:B:D247	B:B:S245	4.42	Yes	No	5	9	9
824	B:B:D247	B:B:T249	14.45	Yes	No	5	9	6
825	B:B:D247	B:B:R251	5.96	Yes	Yes	5	9	8
826	B:B:R251	B:B:T249	10.35	Yes	No	5	8	6
827	B:B:S265	B:B:T249	4.8	No	No	0	2	6
828	B:B:C250	B:B:Y264	4.03	No	Yes	0	8	5
829	B:B:C250	B:B:I273	4.91	No	No	0	8	6
830	B:B:F253	B:B:R251	4.28	Yes	Yes	5	6	8
831	B:B:E260	B:B:R251	11.63	No	Yes	5	6	8
832	B:B:R251	B:B:T263	10.35	Yes	No	5	8	1
833	B:B:L252	B:B:L261	4.15	No	No	0	7	5
834	B:B:L252	B:B:Y264	3.52	No	Yes	0	7	5
835	B:B:E260	B:B:F253	3.5	No	Yes	5	6	6
836	B:B:A257	B:B:D254	4.63	No	No	0	7	9
837	B:B:D254	B:B:L261	8.14	No	No	0	9	5
838	B:B:D254	G:G:A33	3.09	No	No	0	9	7
839	B:B:R256	G:G:I28	8.77	No	No	0	9	4
840	B:B:R256	G:G:D36	5.96	No	No	0	9	5
841	B:B:D258	G:G:R27	10.72	Yes	No	5	7	8
842	B:B:Q259	G:G:V30	4.3	No	No	0	6	8
843	B:B:E260	B:B:T263	7.06	No	No	5	6	1
844	B:B:M262	B:B:Y264	11.97	Yes	Yes	9	4	5
845	B:B:A302	B:B:M262	3.22	No	Yes	9	2	4
846	B:B:W297	B:B:Y264	3.86	Yes	Yes	9	8	5
847	B:B:A302	B:B:Y264	2.67	No	Yes	9	2	5
848	B:B:H266	B:B:N268	11.48	No	No	0	4	4
849	B:B:H266	B:B:R304	4.51	No	Yes	0	4	5
850	B:B:I269	B:B:N268	5.66	Yes	No	0	4	4
851	B:B:I269	B:B:Y289	3.63	Yes	Yes	9	4	7
852	B:B:D291	B:B:I269	2.8	Yes	Yes	9	8	4
853	B:B:C271	B:B:Y289	2.69	Yes	Yes	9	5	7
854	B:B:C271	B:B:D290	6.22	Yes	No	0	5	6
855	B:B:C271	B:B:D291	3.11	Yes	Yes	9	5	8
856	B:B:I273	B:B:Y289	7.25	No	Yes	0	6	7
857	B:B:S275	B:B:T274	3.2	No	No	0	8	8
858	B:B:D290	B:B:T274	2.89	No	No	0	6	8
859	B:B:L318	B:B:S275	3	Yes	No	0	6	8
860	B:B:S277	B:B:V320	6.46	No	No	0	5	7
861	B:B:F278	B:B:L285	6.09	Yes	No	13	7	6
862	B:B:S279	G:G:D48	8.83	No	Yes	0	9	9
863	B:B:K280	G:G:D48	2.77	No	Yes	0	1	9
864	B:B:S281	G:G:D48	4.42	No	Yes	1	9	9
865	B:B:S281	G:G:L51	3	No	Yes	1	9	6
866	B:B:D298	B:B:R283	4.76	No	Yes	1	9	9
867	B:B:R283	G:G:A45	4.15	Yes	No	0	9	4
868	B:B:R283	G:G:L51	10.93	Yes	Yes	1	9	6
869	B:B:L284	B:B:V296	5.96	No	Yes	0	5	5
870	B:B:L284	G:G:L51	4.15	No	Yes	0	5	6
871	B:B:L286	B:B:V296	8.94	No	Yes	0	7	5
872	B:B:L286	B:B:L318	5.54	No	Yes	1	7	6
873	B:B:L286	B:B:V327	4.47	No	Yes	1	7	6
874	B:B:A287	B:B:Y289	2.67	No	Yes	0	6	7
875	B:B:D291	B:B:Y289	4.6	Yes	Yes	9	8	7
876	B:B:N295	B:B:Y289	9.3	Yes	Yes	9	6	7
877	B:B:W297	B:B:Y289	7.72	Yes	Yes	9	8	7
878	B:B:D290	B:B:R314	21.44	No	No	0	6	8
879	B:B:D291	B:B:N293	10.77	Yes	No	0	8	5
880	B:B:N293	B:B:V307	2.96	No	No	0	5	3
881	B:B:A309	B:B:N293	3.13	No	No	0	3	5
882	B:B:C294	B:B:L308	4.76	Yes	Yes	0	5	7
883	B:B:C294	B:B:V315	5.12	Yes	No	1	5	7
884	B:B:C294	B:B:L318	3.17	Yes	Yes	1	5	6
885	B:B:C294	B:B:T329	3.38	Yes	Yes	1	5	8
886	B:B:N295	B:B:W297	5.65	Yes	Yes	9	6	8
887	B:B:N295	B:B:R304	3.62	Yes	Yes	9	6	5
888	B:B:N295	B:B:V307	4.43	Yes	No	0	6	3
889	B:B:L308	B:B:V296	2.98	Yes	Yes	0	7	5
890	B:B:R304	B:B:W297	7	Yes	Yes	9	5	8
891	B:B:D298	B:B:K301	6.91	No	Yes	0	9	5
892	B:B:L300	G:G:M38	2.83	No	No	0	6	4
893	B:B:L308	B:B:W339	13.67	Yes	No	0	7	9
894	B:B:H311	B:B:V315	4.15	Yes	No	1	9	7
895	B:B:H311	B:B:T329	9.58	Yes	Yes	1	9	8
896	B:B:H311	B:B:S331	11.16	Yes	No	1	9	9
897	B:B:D333	B:B:H311	6.3	Yes	Yes	1	9	9
898	B:B:H311	B:B:K337	6.55	Yes	No	0	9	6
899	B:B:D312	B:B:D333	6.65	No	Yes	0	5	9
900	B:B:N313	B:B:W332	10.17	No	Yes	0	7	9
901	B:B:R314	B:B:W332	18.99	No	Yes	0	8	9
902	B:B:S331	B:B:V315	3.23	No	No	1	9	7
903	B:B:C317	B:B:S316	3.44	No	No	0	7	9
904	B:B:S316	B:B:W332	4.94	No	Yes	0	9	9
905	B:B:L318	B:B:V327	2.98	Yes	Yes	1	6	6
906	B:B:L318	B:B:T329	2.95	Yes	Yes	1	6	8
907	B:B:V320	B:B:V327	6.41	No	Yes	0	7	6
908	B:B:D323	B:B:T321	5.78	No	No	1	7	7
909	B:B:D323	B:B:M325	4.16	No	Yes	1	7	5
910	B:B:M325	B:B:N340	2.8	Yes	Yes	1	5	9
911	B:B:M325	G:G:P49	6.71	Yes	Yes	0	5	7
912	B:B:M325	G:G:N59	2.8	Yes	Yes	1	5	9
913	B:B:M325	G:G:P60	8.39	Yes	Yes	1	5	9
914	B:B:A326	G:G:F61	4.16	No	Yes	0	7	8
915	B:B:V327	G:G:L50	2.98	Yes	Yes	1	6	9
916	B:B:T329	B:B:W339	8.49	Yes	No	0	8	9
917	B:B:D333	B:B:S331	7.36	Yes	No	1	9	9
918	B:B:D333	B:B:F335	10.75	Yes	No	0	9	4
919	B:B:I338	G:G:F61	5.02	No	Yes	1	5	8
920	B:B:N340	G:G:L50	2.75	Yes	Yes	1	9	9
921	B:B:N340	G:G:N59	6.81	Yes	Yes	1	9	9
922	G:G:K20	G:G:V16	3.04	No	No	0	6	7
923	G:G:D26	G:G:I25	2.8	No	No	0	1	2
924	G:G:I25	G:G:R27	5.01	No	No	0	2	8
925	G:G:A33	G:G:I28	3.25	No	No	0	7	4
926	G:G:K29	G:G:S31	6.12	No	No	27	4	9
927	G:G:D36	G:G:K32	4.15	No	No	0	5	5
928	G:G:H44	G:G:Y40	10.89	No	No	0	6	6
929	G:G:E47	G:G:H44	7.39	No	No	0	3	6
930	G:G:D48	G:G:P49	4.83	Yes	Yes	0	9	7
931	G:G:D48	G:G:L50	2.71	Yes	Yes	1	9	9
932	G:G:D48	G:G:L51	12.21	Yes	Yes	1	9	6
933	G:G:P53	G:G:T52	3.5	No	No	0	8	4
934	G:G:P55	G:G:V54	3.53	No	No	28	5	6
935	G:G:E58	G:G:V54	4.28	No	No	28	5	6
936	G:G:E58	G:G:P55	11	No	No	28	5	5
937	G:G:N59	G:G:P60	6.52	Yes	Yes	1	9	9
938	G:G:F61	G:G:P60	4.33	Yes	Yes	1	8	9
939	A:A:L232	A:A:R242	2.43	No	No	0	8	9
940	B:B:F292	B:B:N313	2.42	No	No	0	4	7
941	R:R:E351	R:R:F352	2.33	No	No	0	3	7
942	B:B:R22	G:G:E22	2.33	Yes	No	0	6	9
943	A:A:E289	A:A:Y287	2.24	No	Yes	0	6	7
944	A:A:E298	A:A:Y290	2.24	No	Yes	14	4	7
945	L:L:?1	R:R:G327	2.21	Yes	No	0	0	7
946	B:B:R304	B:B:R42	2.13	Yes	No	0	5	2
947	B:B:G115	B:B:G116	2.11	No	No	0	9	9
948	B:B:G238	B:B:P194	2.03	No	No	0	7	4
949	B:B:G324	G:G:P49	2.03	No	Yes	0	9	7
950	B:B:C271	B:B:G272	1.96	Yes	No	0	5	4
951	B:B:C294	B:B:G288	1.96	Yes	No	0	5	7
952	B:B:C317	B:B:G330	1.96	No	No	0	7	5
953	A:A:A41	A:A:G42	1.95	No	No	0	7	8
954	B:B:A140	B:B:G141	1.95	No	No	0	5	5
955	B:B:A208	B:B:G202	1.95	No	No	0	6	6
956	B:B:A309	B:B:G310	1.95	No	No	0	3	5
957	B:B:A106	B:B:P107	1.87	No	No	0	6	6
958	R:R:G201	R:R:S147	1.86	No	No	0	6	6
959	R:R:G269	R:R:S268	1.86	No	No	0	1	4
960	B:B:G41	B:B:V40	1.84	No	No	0	1	3
961	B:B:G244	B:B:V276	1.84	No	No	0	5	6
962	B:B:G306	B:B:V296	1.84	No	Yes	0	4	5
963	R:R:G84	R:R:T120	1.82	No	No	0	8	5
964	B:B:G131	B:B:T128	1.82	No	Yes	0	4	3
965	B:B:G185	B:B:T164	1.82	No	No	0	5	6
966	B:B:G174	B:B:T173	1.82	No	No	0	4	5
967	B:B:G182	B:B:T181	1.82	No	No	0	6	2
968	B:B:A60	B:B:C103	1.81	No	No	0	7	8
969	G:G:P55	G:G:S57	1.78	No	No	0	5	6
970	G:G:P49	G:G:V54	1.77	Yes	No	0	7	6
971	R:R:G133	R:R:M132	1.75	No	No	0	2	4
972	R:R:P183	R:R:T182	1.75	No	No	0	1	7
973	B:B:P107	B:B:T65	1.75	No	No	0	6	1
974	A:A:G45	A:A:K270	1.74	No	Yes	0	9	9
975	A:A:G202	A:A:K46	1.74	No	Yes	0	9	9
976	B:B:G182	B:B:K209	1.74	No	Yes	0	6	6
977	R:R:C323	R:R:S319	1.72	No	No	0	6	4
978	A:A:G27	B:B:L55	1.71	No	No	0	5	6
979	A:A:A41	A:A:S44	1.71	No	No	0	7	9
980	B:B:G53	B:B:L55	1.71	No	No	0	9	6
981	B:B:C114	B:B:V100	1.71	No	No	0	8	9
982	A:A:G352	R:R:N344	1.7	No	No	0	8	7
983	B:B:A11	G:G:V16	1.7	No	No	0	5	7
984	B:B:G144	B:B:N119	1.7	No	No	0	8	9
985	B:B:A231	B:B:V276	1.7	No	No	0	5	6
986	R:R:I310	R:R:P311	1.69	No	No	0	4	1
987	R:R:M207	R:R:P203	1.68	No	No	0	5	8
988	A:A:E216	A:A:G217	1.64	No	No	0	7	5
989	B:B:E215	B:B:G216	1.64	No	No	0	3	4
990	R:R:A177	R:R:I169	1.62	No	No	0	6	5
991	A:A:I19	B:B:A92	1.62	Yes	No	0	9	6
992	B:B:I33	G:G:A34	1.62	No	No	0	3	6
993	B:B:A248	B:B:I269	1.62	No	Yes	0	5	4
994	R:R:A208	R:R:K143	1.61	No	No	0	5	6
995	B:B:D38	B:B:P39	1.61	No	No	0	1	1
996	R:R:S121	R:R:T122	1.6	No	Yes	0	5	6
997	A:A:S47	A:A:T48	1.6	No	No	0	9	9
998	B:B:S207	B:B:T223	1.6	No	No	0	5	2
999	R:R:T69	R:R:V318	1.59	No	No	0	4	1
1000	R:R:C237	R:R:L233	1.59	No	No	0	5	3
1001	R:R:T251	R:R:V247	1.59	No	No	0	5	6
1002	R:R:T251	R:R:V288	1.59	No	No	0	5	8
1003	A:A:T187	A:A:V185	1.59	Yes	No	0	6	5
1004	A:A:T327	A:A:T329	1.57	No	No	0	8	9
1005	A:A:A12	B:B:N88	1.56	No	Yes	0	4	7
1006	A:A:I285	A:A:S281	1.55	No	No	0	3	7
1007	R:R:I73	R:R:V318	1.54	No	No	0	6	1
1008	A:A:I344	R:R:V264	1.54	Yes	No	0	6	6
1009	B:B:M262	B:B:S31	1.53	Yes	No	0	4	1
1010	R:R:I68	R:R:T72	1.52	No	No	0	3	4
1011	R:R:M132	R:R:V128	1.52	No	No	0	4	3
1012	B:B:A21	B:B:Q17	1.52	No	No	0	4	4
1013	B:B:Q17	G:G:A23	1.52	No	No	0	4	8
1014	R:R:F86	R:R:G87	1.51	No	No	0	5	8
1015	A:A:A30	A:A:E33	1.51	No	Yes	0	3	6
1016	R:R:K102	R:R:T103	1.5	No	No	0	7	7
1017	B:B:K15	B:B:T223	1.5	No	No	0	6	2
1018	R:R:L307	R:R:V308	1.49	No	No	0	5	2
1019	A:A:L5	A:A:V13	1.49	Yes	No	0	2	3
1020	R:R:I140	R:R:I144	1.47	No	No	0	1	5
1021	A:A:D315	R:R:S270	1.47	No	No	0	3	2
1022	G:G:L51	G:G:T52	1.47	Yes	No	0	6	4
1023	R:R:I71	R:R:M67	1.46	No	No	0	5	2
1024	R:R:N185	R:R:T182	1.46	Yes	No	0	4	7
1025	A:A:T182	B:B:N119	1.46	No	No	0	7	9
1026	B:B:N125	B:B:T128	1.46	No	Yes	0	4	3
1027	B:B:A206	B:B:H225	1.46	No	Yes	0	4	9
1028	G:G:A43	G:G:H44	1.46	No	No	0	4	6
1029	R:R:I258	R:R:K262	1.45	No	No	0	5	4
1030	R:R:K100	R:R:K102	1.44	No	No	0	6	7
1031	B:B:Q75	B:B:S98	1.44	Yes	No	0	9	8
1032	A:A:I343	R:R:L178	1.43	No	No	0	7	4
1033	R:R:I244	R:R:L248	1.43	No	No	0	4	3
1034	R:R:I258	R:R:L285	1.43	No	No	0	5	5
1035	R:R:I188	R:R:N185	1.42	No	Yes	0	3	4
1036	R:R:Q316	R:R:T313	1.42	No	No	0	3	3
1037	R:R:E231	R:R:T227	1.41	No	No	0	4	3
1038	A:A:E297	A:A:T295	1.41	No	No	0	4	5
1039	B:B:K301	B:B:N35	1.4	Yes	No	0	5	1
1040	A:A:P288	A:A:Y287	1.39	No	Yes	0	5	7
1041	B:B:H54	B:B:S334	1.39	Yes	No	0	9	4
1042	A:A:D20	A:A:K17	1.38	No	No	0	6	4
1043	B:B:D303	B:B:K301	1.38	No	Yes	0	2	5
1044	R:R:E343	R:R:K346	1.35	No	No	0	5	8
1045	A:A:E245	A:A:K248	1.35	No	No	0	9	5
1046	G:G:E47	G:G:K46	1.35	No	No	0	3	1
1047	A:A:C305	A:A:Y302	1.34	No	Yes	0	3	6
1048	A:A:E276	A:A:L273	1.33	No	No	0	5	6
1049	A:A:D337	A:A:D341	1.33	No	No	0	4	8
1050	B:B:A299	B:B:Y264	1.33	No	Yes	0	5	5
1051	A:A:E25	A:A:N22	1.31	No	No	0	4	4
1052	R:R:F315	R:R:T313	1.3	No	No	0	2	3
1053	B:B:E10	B:B:Q6	1.27	No	No	0	8	1
1054	R:R:T99	R:R:Y98	1.25	No	No	0	6	4
1055	A:A:I19	A:A:R15	1.25	Yes	No	0	9	5
1056	G:G:I9	G:G:R13	1.25	No	No	0	2	6
1057	R:R:F86	R:R:L90	1.22	No	No	0	5	6
1058	A:A:E28	R:R:R184	1.16	No	No	0	4	3
1059	R:R:R279	R:R:R282	1.07	Yes	No	0	7	5
1060	A:A:R21	A:A:R24	1.07	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:C81	3.77	4	20	6
2	R:R:V91	3.2	5	0	9
3	R:R:Y108	6.49	5	0	7
4	R:R:F110	5.34	4	0	6
5	R:R:D116	8.12	4	3	9
6	R:R:T122	3.435	4	0	6
7	R:R:L123	3.9875	4	0	7
8	R:R:W135	9.62429	7	3	8
9	R:R:F137	8.862	5	3	6
10	R:R:V145	5.105	4	0	5
11	R:R:I146	3.035	4	0	4
12	R:R:D149	7.9075	4	3	5
13	R:R:Y151	6.205	4	3	5
14	R:R:F154	3.9	6	3	6
15	R:R:T155	7.95	4	3	7
16	R:R:L160	4.735	4	3	8
17	R:R:Y168	6.5425	4	24	8
18	R:R:V171	4.42	4	10	8
19	R:R:F180	6.7825	4	23	3
20	R:R:R181	6.70333	6	22	7
21	R:R:N185	3.6975	4	23	4
22	R:R:N190	5.7075	4	0	7
23	R:R:S197	3.875	4	3	8
24	R:R:F223	5.168	5	0	6
25	R:R:P226	3.865	4	17	4
26	R:R:Y229	6.5	4	17	1
27	R:R:W230	5.7975	4	17	1
28	R:R:K235	3.6525	4	0	4
29	R:R:F243	8.0675	4	0	8
30	R:R:P246	3.77	4	3	8
31	R:R:Y254	5.77667	6	3	9
32	R:R:R260	3.3	4	0	5
33	R:R:L261	3.9075	4	10	8
34	R:R:L267	4.43	4	0	1
35	R:R:R279	5.245	4	10	7
36	R:R:F291	4.62286	7	3	9
37	R:R:W295	6.70833	6	3	8
38	R:R:T296	4.34	4	0	5
39	R:R:H299	8.15	4	0	7
40	R:R:W320	6.204	5	0	4
41	R:R:H321	9.5725	4	19	4
42	R:R:Y328	8.0975	4	3	7
43	R:R:N330	6.348	5	3	9
44	R:R:N334	5.792	5	3	9
45	R:R:L337	4.2325	4	3	8
46	R:R:Y338	6.49	5	3	9
47	R:R:F340	3.915	4	0	6
48	R:R:F345	6.13	4	21	8
49	A:A:L5	2.4925	4	0	2
50	A:A:I19	2.885	4	7	9
51	A:A:E33	4.3375	4	0	6
52	A:A:V34	4.772	5	4	5
53	A:A:L36	3.465	4	4	7
54	A:A:L38	5.91	4	4	8
55	A:A:L39	4.135	4	2	9
56	A:A:K46	5.145	4	4	9
57	A:A:I49	4.152	5	4	7
58	A:A:Q52	5.6575	4	0	9
59	A:A:M53	3.044	5	4	8
60	A:A:I184	3.465	4	2	9
61	A:A:T187	3.29	5	4	6
62	A:A:F189	5.9525	4	4	9
63	A:A:F191	9.355	4	4	5
64	A:A:L194	5.28	4	4	4
65	A:A:F196	7.27	5	4	7
66	A:A:K197	6.5625	4	2	6
67	A:A:F199	6.96167	6	2	5
68	A:A:Q204	5.535	4	2	9
69	A:A:S206	3.965	4	2	8
70	A:A:R208	5.95	4	2	9
71	A:A:W211	6.21143	7	2	9
72	A:A:H213	5.53	4	2	8
73	A:A:F215	5.34167	6	2	9
74	A:A:I221	4.346	5	2	8
75	A:A:I222	3.145	4	4	7
76	A:A:F223	5.17667	6	0	9
77	A:A:V225	3.6575	4	0	7
78	A:A:L227	5.8775	4	12	7
79	A:A:Y230	6.61	4	0	8
80	A:A:F250	6.174	5	16	9
81	A:A:I253	5.4425	4	2	8
82	A:A:C254	4.3125	4	16	5
83	A:A:N256	4.665	4	2	8
84	A:A:W258	7.814	5	2	5
85	A:A:F259	5.542	5	2	9
86	A:A:I265	3.225	6	4	8
87	A:A:L266	5.7475	4	12	9
88	A:A:F267	4.13125	8	4	9
89	A:A:L268	5.064	5	12	8
90	A:A:K270	3.795	4	0	9
91	A:A:F274	4.826	5	12	9
92	A:A:Y287	3.91333	6	14	7
93	A:A:Y290	7.254	5	14	7
94	A:A:Y302	8.15	4	14	6
95	A:A:F307	3.32	6	12	8
96	A:A:N311	5.0425	4	16	8
97	A:A:Y320	6.98167	6	4	7
98	A:A:F323	3.445	4	12	4
99	A:A:T324	5.3875	4	4	9
100	A:A:F336	7.04	5	4	8
101	A:A:I344	3.3075	4	0	6
102	A:A:L348	2.762	5	10	9
103	A:A:F354	4.45143	7	10	5
104	B:B:L14	3.4025	4	26	8
105	B:B:R22	4.3725	4	5	6
106	B:B:D27	6.4325	4	27	8
107	B:B:M45	4.61	4	1	4
108	B:B:R48	6.208	5	1	7
109	B:B:H54	7.74714	7	7	9
110	B:B:K57	9.6775	4	2	9
111	B:B:Y59	6.548	5	2	8
112	B:B:W63	6.436	5	1	7
113	B:B:R68	9.8325	4	1	5
114	B:B:S72	5.3725	4	7	9
115	B:B:Q75	4.9275	4	2	9
116	B:B:I81	4.925	4	8	7
117	B:B:W82	9.78857	7	7	9
118	B:B:Y85	10.43	4	1	4
119	B:B:N88	6.6675	4	0	7
120	B:B:K89	6.27	7	7	9
121	B:B:H91	5.7075	4	8	5
122	B:B:I93	7.2175	4	8	7
123	B:B:W99	7.832	5	2	9
124	B:B:Y105	4.576	5	0	6
125	B:B:N110	5.865	4	11	4
126	B:B:Y111	5.625	4	11	4
127	B:B:L117	4.952	5	2	9
128	B:B:I123	3.432	5	11	6
129	B:B:Y124	6.04	6	8	6
130	B:B:L126	4.27	4	8	5
131	B:B:T128	2.1725	4	0	3
132	B:B:V133	4.255	4	8	4
133	B:B:H142	9.9	4	15	9
134	B:B:Y145	4.45	6	2	8
135	B:B:C148	5.0325	4	6	6
136	B:B:F151	4.12833	6	11	9
137	B:B:V158	4.2025	4	0	5
138	B:B:T159	5.785	4	15	9
139	B:B:D163	7.44	4	0	9
140	B:B:L168	3.62	4	6	6
141	B:B:W169	10.858	5	15	8
142	B:B:F180	6.216	5	6	7
143	B:B:H183	6.684	5	6	9
144	B:B:V187	4.978	5	6	9
145	B:B:M188	3.5575	4	0	8
146	B:B:F199	6.7175	4	6	9
147	B:B:S201	3.91	4	6	9
148	B:B:D205	5.995	4	0	9
149	B:B:K209	5.50667	6	6	6
150	B:B:W211	8.415	6	6	8
151	B:B:Q220	8.4075	4	5	7
152	B:B:F222	8.024	5	5	8
153	B:B:H225	8.34	7	5	9
154	B:B:I229	5.5575	4	5	7
155	B:B:I232	5.85	4	5	8
156	B:B:F234	5.426	5	5	5
157	B:B:F235	6.95571	7	13	6
158	B:B:P236	5.67	4	13	7
159	B:B:F241	6.10571	7	5	6
160	B:B:T243	5.644	5	5	8
161	B:B:D247	7.282	5	5	9
162	B:B:R251	9.72833	6	5	8
163	B:B:F253	6.41857	7	5	6
164	B:B:L255	6.2475	4	5	6
165	B:B:D258	9.28	4	5	7
166	B:B:M262	5.9475	4	9	4
167	B:B:Y264	4.56333	6	9	5
168	B:B:I269	3.4275	4	9	4
169	B:B:C271	3.495	4	9	5
170	B:B:F278	4.194	5	13	7
171	B:B:R283	5.94	4	1	9
172	B:B:Y289	5.40857	7	9	7
173	B:B:D291	5.32	4	9	8
174	B:B:C294	3.678	5	1	5
175	B:B:N295	5.75	4	9	6
176	B:B:V296	4.93	4	0	5
177	B:B:W297	6.0575	4	9	8
178	B:B:K301	4.5125	4	0	5
179	B:B:R304	4.315	4	9	5
180	B:B:L308	6.4125	4	0	7
181	B:B:H311	7.548	5	1	9
182	B:B:L318	3.528	5	1	6
183	B:B:M325	4.972	5	1	5
184	B:B:V327	4.21	4	1	6
185	B:B:T329	6.1	4	1	8
186	B:B:W332	10.1114	7	2	9
187	B:B:D333	7.765	4	1	9
188	B:B:L336	5.916	5	7	7
189	B:B:N340	5.724	5	1	9
190	G:G:D48	5.96167	6	1	9
191	G:G:P49	3.835	4	0	7
192	G:G:L50	3.8775	4	1	9
193	G:G:L51	6.352	5	1	6
194	G:G:N59	5.2375	4	1	9
195	G:G:P60	7.5925	4	1	9
196	G:G:F61	5.23714	7	1	8
197	L:L:?1	5.97308	13	3	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N330	R:R:N334	24.377	8.17	Yes	Yes	3	9	9
2	R:R:N330	R:R:W295	23.5516	7.91	Yes	Yes	3	9	8
3	L:L:?1	R:R:W295	61.4679	5.16	Yes	Yes	3	0	8
4	L:L:?1	R:R:I324	11.9079	5.54	Yes	No	0	0	5
5	R:R:I324	R:R:W320	11.338	7.05	No	Yes	0	5	4
6	R:R:F291	R:R:L160	26.4984	2.44	Yes	Yes	3	9	8
7	R:R:F291	R:R:W295	46.8728	7.02	Yes	Yes	3	9	8
8	A:A:C351	R:R:R181	10.6059	5.57	No	Yes	0	4	7
9	A:A:C351	A:A:L353	10.8069	3.17	No	No	0	4	7
10	A:A:L353	R:R:R167	87.2345	14.58	No	No	0	7	9
11	R:R:R167	R:R:Y338	57.2351	6.17	No	Yes	0	9	9
12	R:R:L160	R:R:Y338	27.0546	8.21	Yes	Yes	3	8	9
13	R:R:R167	R:R:Y254	29.8554	8.23	No	Yes	0	9	9
14	R:R:I250	R:R:Y254	26.5122	3.63	No	Yes	3	8	9
15	R:R:F291	R:R:I250	26.4032	5.02	Yes	No	3	9	8
16	R:R:N334	R:R:Y338	27.8	6.98	Yes	Yes	3	9	9
17	L:L:?1	R:R:W135	10.8317	2.95	Yes	Yes	3	0	8
18	L:L:?1	R:R:I146	12.4907	2.77	Yes	Yes	0	0	4
19	R:R:I146	R:R:L221	10.2292	2.85	Yes	No	0	4	4
20	R:R:L221	R:R:Y150	10.2141	3.52	No	No	0	4	4
21	L:L:?1	R:R:Y150	11.3525	6.07	Yes	No	0	0	4
22	A:A:L348	A:A:L353	97.8443	2.77	Yes	No	0	9	7
23	A:A:L348	R:R:L261	19.8445	2.77	Yes	Yes	10	9	8
24	A:A:I344	R:R:P174	59.2599	5.08	Yes	No	0	6	8
25	A:A:I344	A:A:L348	58.0958	2.85	Yes	Yes	0	6	9
26	A:A:I343	R:R:P174	59.0186	3.39	No	No	0	7	8
27	A:A:F215	A:A:L37	30.0298	9.74	Yes	No	2	9	9
28	A:A:L37	A:A:L39	30.0645	5.54	No	Yes	2	9	9
29	A:A:F223	A:A:L39	87.8783	2.44	Yes	Yes	0	9	9
30	A:A:F223	A:A:G40	99.8373	3.01	Yes	No	0	9	9
31	A:A:G40	A:A:K46	99.9037	3.49	No	Yes	0	9	9
32	A:A:K46	A:A:L38	100	7.05	Yes	Yes	4	9	8
33	A:A:L38	A:A:M198	20.2422	4.24	Yes	No	4	8	7
34	A:A:F189	A:A:M198	20.0771	2.49	Yes	No	4	9	7
35	A:A:F189	A:A:F196	20.1135	15	Yes	Yes	4	9	7
36	A:A:F196	A:A:V339	39.5804	3.93	Yes	No	4	7	8
37	A:A:I343	A:A:V339	59.1989	3.07	No	No	0	7	8
38	A:A:I222	A:A:L38	79.9378	2.85	Yes	Yes	4	7	8
39	A:A:I222	A:A:L36	39.8134	4.28	Yes	Yes	4	7	7
40	A:A:F196	A:A:L36	19.89	3.65	Yes	Yes	4	7	7
41	A:A:L36	A:A:V34	19.8896	2.98	Yes	Yes	4	7	5
42	A:A:V339	A:A:V34	19.7096	6.41	No	Yes	4	8	5
43	A:A:I222	A:A:I265	39.5548	2.94	Yes	Yes	4	7	8
44	A:A:I265	A:A:Y320	40.1411	3.63	Yes	Yes	4	8	7
45	A:A:E318	A:A:Y320	40.1965	5.61	No	Yes	0	4	7
46	A:A:E318	R:R:M266	40.2087	8.12	No	No	0	4	4
47	R:R:L267	R:R:M266	39.9834	2.83	Yes	No	0	1	4
48	R:R:L261	R:R:L267	19.9259	4.15	Yes	Yes	0	8	1
49	A:A:F354	R:R:L267	20.0679	2.44	Yes	Yes	0	5	1
50	A:A:F354	A:A:L348	20.0773	2.44	Yes	Yes	10	5	9
51	R:R:F223	R:R:W230	13.6694	3.01	Yes	Yes	0	6	1
52	B:B:N88	B:B:T86	16.3851	7.31	Yes	No	0	7	6
53	B:B:R68	B:B:T86	16.8023	3.88	Yes	No	1	5	6
54	B:B:A326	G:G:F61	19.263	4.16	No	Yes	0	7	8
55	B:B:A326	B:B:W63	19.4543	2.59	No	Yes	0	7	7
56	B:B:M61	B:B:W63	22.1905	5.82	No	Yes	1	6	7
57	B:B:C317	B:B:M61	22.5789	3.24	No	No	0	7	6
58	B:B:C317	B:B:S316	22.966	3.44	No	No	0	7	9
59	B:B:S316	B:B:W332	23.1601	4.94	No	Yes	0	9	9
60	A:A:W258	B:B:W332	31.681	3.75	Yes	Yes	2	5	9
61	A:A:N256	A:A:W258	32.1061	6.78	Yes	Yes	2	8	5
62	A:A:F259	A:A:N256	29.7992	4.83	Yes	Yes	2	9	8
63	A:A:F259	A:A:I221	30.0953	10.05	Yes	Yes	2	9	8
64	A:A:I221	A:A:L39	30.3878	2.85	Yes	Yes	2	8	9
65	A:A:S16	B:B:N88	13.0332	7.45	No	Yes	0	7	7
66	A:A:S16	B:B:K89	12.6139	4.59	No	Yes	0	7	9
67	A:A:I253	A:A:L39	27.3492	5.71	Yes	Yes	2	8	9
68	A:A:F223	A:A:L266	11.9462	3.65	Yes	Yes	0	9	9
69	B:B:G162	B:B:S161	70.7893	3.71	No	No	0	9	9
70	B:B:G162	B:B:Y145	71.0484	2.9	No	Yes	0	9	8
71	A:A:W211	B:B:Y145	74.9195	6.75	Yes	Yes	2	9	8
72	A:A:R208	A:A:W211	29.4957	6	Yes	Yes	2	9	9
73	A:A:I253	A:A:R208	27.1704	10.02	Yes	Yes	2	8	9
74	A:A:F215	A:A:W211	36.9477	4.01	Yes	Yes	2	9	9
75	A:A:F215	B:B:W99	10.8631	10.02	Yes	Yes	2	9	9
76	A:A:C214	B:B:W99	10.6423	2.61	No	Yes	2	7	9
77	B:B:Q75	B:B:W99	10.8074	7.67	Yes	Yes	2	9	9
78	B:B:R22	G:G:E22	21.3972	2.33	Yes	No	0	6	9
79	B:B:T221	G:G:E22	21.7093	11.29	No	No	0	7	9
80	B:B:K209	B:B:T221	22.0213	13.51	Yes	No	0	6	7
81	B:B:H183	B:B:K209	24.4339	5.24	Yes	Yes	6	9	6
82	B:B:H183	B:B:V187	25.675	8.3	Yes	Yes	6	9	9
83	B:B:S160	B:B:V187	31.9307	4.85	No	Yes	6	6	9
84	B:B:C148	B:B:S160	32.2358	3.44	Yes	No	6	6	6
85	B:B:C148	B:B:T102	49.5618	3.38	Yes	No	0	6	8
86	B:B:C149	B:B:T102	49.8676	3.38	No	No	0	8	8
87	B:B:C149	B:B:T159	65.6673	3.38	No	Yes	0	8	9
88	B:B:H142	B:B:T159	65.9141	6.85	Yes	Yes	15	9	9
89	B:B:H142	B:B:S161	68.3816	9.76	Yes	No	0	9	9
90	B:B:D258	B:B:R22	15.134	3.57	Yes	Yes	5	7	6
91	B:B:W297	B:B:Y264	10.4638	3.86	Yes	Yes	9	8	5
92	B:B:W297	B:B:Y289	11.2807	7.72	Yes	Yes	9	8	7
93	B:B:C271	B:B:Y289	14.5998	2.69	Yes	Yes	9	5	7
94	B:B:C271	B:B:D290	16.8881	6.22	Yes	No	0	5	6
95	B:B:D290	B:B:R314	29.0202	21.44	No	No	0	6	8
96	B:B:R314	B:B:W332	29.2135	18.99	No	Yes	0	8	9
97	B:B:L318	B:B:S275	13.0932	3	Yes	No	0	6	8
98	B:B:S275	B:B:T274	13.2823	3.2	No	No	0	8	8
99	B:B:D290	B:B:T274	13.4714	2.89	No	No	0	6	8
100	B:B:H62	B:B:R150	10.1508	6.77	No	No	0	6	6
101	B:B:C148	B:B:R150	11.3683	6.96	Yes	No	0	6	6
102	B:B:C149	B:B:I157	16.1006	3.27	No	No	0	8	7
103	B:B:D258	B:B:F222	13.2454	7.17	Yes	Yes	5	7	8
104	R:R:F223	R:R:L221	19.3042	3.65	Yes	No	0	6	4
105	B:B:W332	B:B:Y59	10.2971	6.75	Yes	Yes	2	9	8
106	B:B:L117	B:B:W99	10.114	6.83	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:T122	R:R:V145	4.76	0	Yes	Yes	6	5	2	2
R:R:D149	R:R:T122	4.34	3	Yes	Yes	5	6	1	2
R:R:L123	R:R:Y328	4.69	0	Yes	Yes	7	7	2	1
R:R:D149	R:R:Q126	7.83	3	Yes	No	5	6	1	1
R:R:Q126	R:R:Y328	6.76	3	No	Yes	6	7	1	1
L:L:?1	R:R:Q126	11.19	3	Yes	No	0	6	0	1
R:R:N129	R:R:W135	9.04	3	No	Yes	4	8	1	1
L:L:?1	R:R:N129	2.66	3	Yes	No	0	4	0	1
R:R:P136	R:R:W135	2.7	3	No	Yes	3	8	2	1
R:R:F137	R:R:W135	23.05	3	Yes	Yes	6	8	2	1
R:R:C142	R:R:W135	5.22	3	No	Yes	9	8	2	1
R:R:V145	R:R:W135	6.13	0	Yes	Yes	5	8	2	1
R:R:C219	R:R:W135	18.28	3	No	Yes	9	8	2	1
L:L:?1	R:R:W135	2.95	3	Yes	Yes	0	8	0	1
R:R:F137	R:R:P136	4.33	3	Yes	No	6	3	2	2
R:R:C142	R:R:C219	7.28	3	No	No	9	9	2	2
R:R:A208	R:R:I146	3.25	0	No	Yes	5	4	2	1
R:R:C219	R:R:I146	3.27	3	No	Yes	9	4	2	1
R:R:I146	R:R:L221	2.85	0	Yes	No	4	4	1	2
L:L:?1	R:R:I146	2.77	3	Yes	Yes	0	4	0	1
R:R:D149	R:R:Y328	8.05	3	Yes	Yes	5	7	1	1
L:L:?1	R:R:D149	11.41	3	Yes	Yes	0	5	0	1
R:R:V204	R:R:Y150	3.79	0	No	No	5	4	2	1
R:R:L221	R:R:Y150	3.52	0	No	No	4	4	2	1
L:L:?1	R:R:Y150	6.07	3	Yes	No	0	4	0	1
R:R:F154	R:R:M153	3.73	3	Yes	No	6	7	2	1
R:R:M153	R:R:W295	4.65	3	No	Yes	7	8	1	1
L:L:?1	R:R:M153	9.14	3	Yes	No	0	7	0	1
R:R:F154	R:R:V238	2.62	3	Yes	No	6	5	2	1
R:R:F291	R:R:I157	7.54	3	Yes	No	9	7	2	2
R:R:I157	R:R:W295	7.05	3	No	Yes	7	8	2	1
L:L:?1	R:R:V238	2.89	3	Yes	No	0	5	0	1
R:R:F291	R:R:W295	7.02	3	Yes	Yes	9	8	2	1
R:R:F291	R:R:N330	4.83	3	Yes	Yes	9	9	2	2
R:R:H299	R:R:W295	8.46	0	Yes	Yes	7	8	2	1
R:R:N330	R:R:W295	7.91	3	Yes	Yes	9	8	2	1
L:L:?1	R:R:W295	5.16	3	Yes	Yes	0	8	0	1
R:R:H299	R:R:I298	2.65	0	Yes	No	7	6	2	1
R:R:C323	R:R:I298	3.27	0	No	No	6	6	2	1
L:L:?1	R:R:I298	2.77	3	Yes	No	0	6	0	1
R:R:I324	R:R:W320	7.05	0	No	Yes	5	4	1	2
L:L:?1	R:R:I324	5.54	3	Yes	No	0	5	0	1
L:L:?1	R:R:Y328	12.89	3	Yes	Yes	0	7	0	1
L:L:?1	R:R:G327	2.21	3	Yes	No	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
73.33	Single	7T2H	Lofentanil	7T2H-μ-Lofentanil-Gi1/β1/γ2
71.43	Single	6TOT	Lemborexant	6TOT-OX₁-Lemborexant
69.23	Single	8Y0H	VUF11418	8Y0H-CXCR3-VUF11418
69.23	Single	8Y0N	VUF11418	8Y0N-CXCR3-VUF11418-Go/β1/γ2
68.75	Single	6ZG4	HTL0009936	6ZG4-M₁-HTL0009936
68.75	Single	7JNI	Olodanrigan	7JNI-AT₂-Olodanrigan
68.75	Consensus	mop_on	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
68.75	Consensus	mop_on_gp	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
66.67	Single	4ZJ8	Suvorexant	4ZJ8-OX₁-Suvorexant
66.67	Single	8EFB	Oliceridine	8EFB-μ-Oliceridine-Gi1/β1/γ2
66.67	Single	8PKM	Befiradol	8PKM-5-HT_1A-Befiradol-Gi1/β1/γ1
66.67	Single	9MQK	Isoquinuclidine	9MQK-κ-Isoquinuclidine
64.71	Consensus	endothelin_off	Orthosteric Ligand	etb_off
64.71	Consensus	etb_off	Orthosteric Ligand	5X93-ET_B-K-8794 5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500
64.29	Single	6ZG9	GSK1034702	6ZG9-M₁-GSK1034702
64.29	Single	7SR8	TAK-925	7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
62.50	Single	7U2L	PubChem 163201242	7U2L-μ-PubChem 163201242-Gi1/β1/γ2
62.50	Single	8XVL	Zibotentan	8XVL-ET_A-Zibotentan
60.00	Single	7UL4	Alvimopan	7UL4-μ-Alvimopan
58.82	Single	5UNH	PubChem 126456406	5UNH-AT₂-PubChem 126456406
58.82	Single	7L1V	PubChem 155491009	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
58.82	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
58.82	Single	9MQL	Isoquinuclidine	9MQL-κ-Isoquinuclidine
58.82	Consensus	opioid_off	Orthosteric Ligand	mop_off nop_off dop_off kop_off
57.89	Consensus	gi_opioid	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
57.14	Single	6B73	MP1104	6B73-κ-MP1104
57.14	Single	7T8X	Acetylcholine	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
57.14	Single	7T90	Acetylcholine	7T90-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
57.14	Single	7T96	Acetylcholine	7T96-M₂-Acetylcholine-LY2119620-Go/β1/γ2
57.14	Single	8EFO	PZM21	8EFO-μ-PZM21-Gi1/β1/γ2
57.14	Single	8FYX	Buspirone	8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1
57.14	Single	8HOC	Imetit	8HOC-H₄-Imetit-Gi1/β1/γ2
57.14	Single	8YNA	Immepip	8YNA-H₄-Immepip-Gi1/β1/γ2
57.14	Consensus	m2_on	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
57.14	Consensus	m2_on_gp	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
56.25	Single	6TO7	Suvorexant	6TO7-OX₁-Suvorexant-Na
56.25	Single	6TP6	Filorexant	6TP6-OX₁-Filorexant
56.25	Single	8DZQ	momSalB	8DZQ-κ-momSalB-Go/β1/γ2
56.25	Single	8DZR	GR89,696	8DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
56.25	Consensus	d4_on	Orthosteric Ligand	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
55.56	Single	5UNG	PubChem 15780052	5UNG-AT₂-PubChem 15780052
55.56	Single	5X93	K-8794	5X93-ET_B-K-8794
55.56	Single	7SK7	CCX662	7SK7-ACKR3-CXCL12-CCX662
55.56	Single	7SK8	CCX662	7SK8-ACKR3-CXCL12-CCX662
55.56	Single	7U2K	C6-guano	7U2K-μ-C6-guano-Gi1/β1/γ2
53.85	Single	7EJK	Oxymetazoline	7EJK-α_2a-Oxymetazoline-Go/β1/γ2
53.85	Single	8IW7	2-Phenylethylamine	8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
53.85	Single	8YN9	Histamine	8YN9-H₄-Histamine-Gi1/β1/γ2
53.85	Single	8YUU	Histamine	8YUU-H₃-Histamine-Gi1/β1/γ1
53.85	Single	9LRC	Histamine	9LRC-H₄-Histamine
53.85	Single	9LRE	Histamine	9LRE-H₄-Histamine-Gi1/β1/γ2
53.85	Consensus	h3_on	Orthosteric Ligand	8YUU-H₃-Histamine-Gi1/β1/γ1
53.85	Consensus	h3_on_gp	Orthosteric Ligand	8YUU-H₃-Histamine-Gi1/β1/γ1
53.33	Single	4ZJC	SB-674042	4ZJC-OX₁-SB-674042
53.33	Single	6IQL	L745870	6IQL-D₄-L745870
53.33	Single	6TOS	GSK1059865	6TOS-OX₁-GSK1059865-Na
53.33	Single	6TPG	EMPA	6TPG-OX₂-EMPA
53.33	Single	6ZFZ	77-LH-28-1	6ZFZ-M₁-77-LH-28-1
53.33	Single	7CMV	PD128907	7CMV-D₃-PD128907-Gi1/β1/γ2
53.33	Single	7EJA	Dexmedetomidine	7EJA-α_2a-Dexmedetomidine-Go/β1/γ2
53.33	Single	7T94	Acetylcholine	7T94-M₂-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
53.33	Single	7TRS	Acetylcholine	7TRS-M₄-Acetylcholine-Gi1/β1/γ2
53.33	Single	8HNM	VUF11222	8HNM-CXCR3-VUF11222-Gi1/β1/γ2
53.33	Single	8PM2	DMCH	8PM2-TA7-DMCH-Gs/β1/γ2
53.33	Single	8THK	A61603	8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
53.33	Single	8THL	Epinephrine	8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
53.33	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
53.33	Consensus	alpha1_on	Orthosteric Ligand	alpha1a_on
53.33	Consensus	alpha1_on_gp	Orthosteric Ligand	alpha1a_on_gp
53.33	Consensus	alpha1a_on	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2
53.33	Consensus	alpha1a_on_gp	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2
53.33	Consensus	ghrelin_off	Orthosteric Ligand	6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
52.94	Single	2YDV	NECA	2YDV-A_2A-NECA
52.94	Single	4DJH	JDTic	4DJH-κ-JDTic
52.94	Single	4U15	Tiotropium	4U15-M₃-Tiotropium
52.94	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
52.94	Single	5G53	NECA	5G53-A_2A-NECA-Gs
52.94	Single	5ZKB	AF-DX 384	5ZKB-M₂-AF-DX 384
52.94	Single	6KO5	PubChem 57400002	6KO5-Ghrelin-PubChem 57400002
52.94	Single	6OL9	Tiotropium	6OL9-M₅-Tiotropium
52.94	Single	6TQ7	SB-334867	6TQ7-OX₁-SB-334867
52.94	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/β1/γ2
52.94	Single	8E0G	BU72	8E0G-μ-BU72
52.94	Single	8EFL	SR17018	8EFL-μ-SR17018-Gi1/β1/γ2
52.94	Single	8IRU	Rotigotine	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
52.94	Single	8JXX	Clobenpropit	8JXX-H₄-Clobenpropit-Gi1/β1/γ2
52.94	Single	8T1V	PubChem 118310209	8T1V-GPR6-PubChem 118310209-Na
52.94	Single	8VVF	JDTic	8VVF-κ-JDTic-Gi1/β1/γ2
52.94	Consensus	d4_on_gp	Orthosteric Ligand	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
52.94	Consensus	h4_on_gp	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2 8JXX-H₄-Clobenpropit-Gi1/β1/γ2
52.94	Consensus	kop_off	Orthosteric Ligand	4DJH-κ-JDTic
52.94	Consensus	m5_off	Orthosteric Ligand	6OL9-M₅-Tiotropium
52.94	Consensus	muscarinic_off	Orthosteric Ligand	m2_off m3_off m4_off m5_off m1_off
52.63	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
52.63	Single	7SK9	CCX662	7SK9-ACKR3-CCX662
52.63	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
52.63	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
52.63	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
52.38	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
50.00	Single	2Y04	Salbutamol	2Y04-β₁-Salbutamol
50.00	Single	3NY8	ICI118-551	3NY8-β₂-ICI118-551
50.00	Single	4EA3	PubChem 10296561	4EA3-NOP-PubChem 10296561
50.00	Single	4EJ4	Naltrindole	4EJ4-δ-Naltrindole
50.00	Single	4GBR	S-Carazolol	4GBR-β₂-S-Carazolol
50.00	Single	4QKX	35V	4QKX-β₂-35V
50.00	Single	4U16	N-Methyl-Scopolamine	4U16-M₃-N-Methyl-Scopolamine
50.00	Single	5CXV	Tiotropium	5CXV-M₁-Tiotropium
50.00	Single	5DHG	C-35	5DHG-NOP-C-35
50.00	Single	5DHH	SB-612111	5DHH-NOP-SB-612111
50.00	Single	5UNF	PubChem 15780052	5UNF-AT₂-PubChem 15780052
50.00	Single	5YC8	N-Methyl-Scopolamine	5YC8-M₂-N-Methyl-Scopolamine
50.00	Single	5ZK8	N-Methyl-Scopolamine	5ZK8-M₂-N-Methyl-Scopolamine
50.00	Single	5ZKC	N-Methyl-Scopolamine	5ZKC-M₂-N-Methyl-Scopolamine
50.00	Single	6Z10	PubChem 154585554	6Z10-Succinate-PubChem 154585554
50.00	Single	7DFP	Spiperone	7DFP-D₂-Spiperone
50.00	Single	7SCG	FH210	7SCG-μ-FH210-Gi1/β1/γ2
50.00	Single	7SQO	TAK-925	7SQO-OX₂-TAK-925-Gi1/β1/γ2
50.00	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/β1/γ2
50.00	Single	7VIF	S-FTY720-P	7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2
50.00	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
50.00	Single	7YAC	Paltusotine	7YAC-SST2-Paltusotine-Gi1/β1/γ2
50.00	Single	7YFC	Histamine	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00	Single	7YFD	Imetit	7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00	Single	7YMJ	Tamsulosin	7YMJ-Alpha1A-Tamsulosin
50.00	Single	8FEG	(DNCP)-Beta-Naloxamine	8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
50.00	Single	8FYT	LSD	8FYT-5-HT_1A-LSD-Gi1/β1/γ1
50.00	Single	8HN8	Histamine	8HN8-H₄-Histamine-Gi1/β1/γ2
50.00	Single	8IRT	Rotigotine	8IRT-D₃-Rotigotine-Gi1/β1/γ2
50.00	Single	8JLJ	T1AM	8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
50.00	Single	8JXR	LSD	8JXR-D₁-LSD
50.00	Single	8PJK	ST171	8PJK-5-HT_1A-ST171-Gi1/β1/γ1
50.00	Single	8T1W	CVN424	8T1W-GPR6-CVN424
50.00	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
50.00	Single	8XVK	Ambrisentan	8XVK-ET_A-Ambrisentan
50.00	Single	8YN5	Histamine	8YN5-H₃-Histamine-Gi1/β1/γ2
50.00	Single	8YN6	Imetit	8YN6-H₃-Imetit-Gi1/β1/γ2
50.00	Single	8YN7	Immethridine	8YN7-H₃-Immethridine-Go/β1/γ2
50.00	Single	8ZSP	LSD	8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
50.00	Single	8ZSS	RO5263397	8ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
50.00	Single	9BQJ	RO76	9BQJ-μ-RO76-Gi1/β1/γ2
50.00	Single	9CBM	Dexmedetomidine	9CBM-α_2a-Dexmedetomidine-Gi1/β1/γ2
50.00	Single	9D61	JDTic	9D61-κ-JDTic-Gi1/β1/γ2
50.00	Single	9GL2	Befiradol	9GL2-5-HT_1A-Befiradol-Gs/β1/γ2
50.00	Single	9JEA	Atropine	9JEA-M₁-Atropine
50.00	Single	9KFJ	PubChem 138319674	9KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
50.00	Single	9PLN	N-(5-methylnaphthalen-1-yl)pyridin-4-amine	9PLN-α_2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
50.00	Single	9PLO	N-(5-methylnaphthalen-1-yl)pyridin-4-amine	9PLO-α_2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
50.00	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off
50.00	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin
50.00	Consensus	alpha_on	Orthosteric Ligand	alpha1_on alpha2_on
50.00	Consensus	cannabinoid_off	Orthosteric Ligand	cb2_off cb1_off
50.00	Consensus	dop_off	Orthosteric Ligand	4EJ4-δ-Naltrindole
50.00	Consensus	dopamine_off	Orthosteric Ligand	d2_off d3_off
50.00	Consensus	gi_amine	Orthosteric Ligand	gi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
50.00	Consensus	gi_histamine	Orthosteric Ligand	8JXX-H₄-Clobenpropit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8YUU-H₃-Histamine-Gi1/β1/γ1 8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2
50.00	Consensus	gi_orexin	Orthosteric Ligand	7SQO-OX₂-TAK-925-Gi1/β1/γ2
50.00	Consensus	gs_trace-amine	Orthosteric Ligand	8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
50.00	Consensus	h4_on	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2 8JXX-H₄-Clobenpropit-Gi1/β1/γ2
50.00	Consensus	m1_off	Orthosteric Ligand	5CXV-M₁-Tiotropium
50.00	Consensus	muscarinic_on	Orthosteric Ligand	m2_on m3_on m4_on m1_on
50.00	Consensus	muscarinic_on_gp	Orthosteric Ligand	m2_on_gp m3_on_gp m4_on_gp m1_on_gp
50.00	Consensus	orexin_on	Orthosteric Ligand	ox2_on
47.62	Consensus	s1p3_on_gp	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
47.37	Single	6DDF	Damgo	6DDF-μ-Damgo-Gi1/β1/γ2
47.37	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/β1/γ2
47.37	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
47.37	Single	8E9Y	Clozapine-N-oxide	8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.37	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/β1/γ2
47.37	Single	8S2T	Isoprenaline	8S2T-β₁-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
47.37	Single	8XIO	L797591	8XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
47.37	Single	9DYE	Buspirone	9DYE-5-HT_1A-Buspirone-Go/β1/γ2
47.37	Consensus	class-a_on	Orthosteric Ligand	sensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
47.37	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
47.37	Consensus	gi_s1p	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7EW3-S1P₃-S1P-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EW1-S1P₅-Siponimod-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
47.37	Consensus	kop_on_gp	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
47.37	Consensus	orexin_on_gp	Orthosteric Ligand	ox2_on_gp
47.06	Single	2RH1	S-Carazolol	2RH1-β₂-S-Carazolol
47.06	Single	2Y03	Isoprenaline	2Y03-β₁-Isoprenaline
47.06	Single	2YCW	S-Carazolol	2YCW-β₁-S-Carazolol
47.06	Single	5C1M	BU72	5C1M-μ-BU72
47.06	Single	5D6L	S-Carazolol	5D6L-β₂-S-Carazolol
47.06	Single	5WIU	Nemonapride	5WIU-D₄-Nemonapride
47.06	Single	5WIV	Nemonapride	5WIV-D₄-Nemonapride-Na
47.06	Single	5WQC	EMPA	5WQC-OX₂-EMPA
47.06	Single	5X7D	S-Carazolol	5X7D-β₂-S-Carazolol-Cmpd-15
47.06	Single	7C4S	S1P	7C4S-S1P₃-S1P
47.06	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/β1/γ2
47.06	Single	7SBF	PZM21	7SBF-μ-PZM21-Gi1/β1/γ2
47.06	Single	8E9Z	Iperoxo	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.06	Single	8I7W	GSK256073	8I7W-HCA₂-GSK256073-Gi1/β1/γ2
47.06	Single	9EE8	Adenosine	9EE8-A_2A-Adenosine-Gs/β1/γ2
47.06	Single	9F34	FOB02-04A	9F34-D₃-FOB02-04A-Go/β1/γ2
47.06	Single	9I52	A1IZU	9I52-D₁-A1IZU-Gs/β1/γ2
47.06	Consensus	5ht2_off	Orthosteric Ligand	5ht2a_off 5ht2b_off 5ht2c_off
47.06	Consensus	alpha_off	Orthosteric Ligand	alpha1_off alpha2_off
47.06	Consensus	alpha_on_gp	Orthosteric Ligand	alpha1_on_gp alpha2_on_gp
47.06	Consensus	amine_off	Orthosteric Ligand	5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
47.06	Consensus	amine_offon	Orthosteric Ligand	amine_off amine_on
47.06	Consensus	amine_offon_gp	Orthosteric Ligand	amine_on_gp amine_off
47.06	Consensus	amine_on	Orthosteric Ligand	5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
47.06	Consensus	beta2_off	Orthosteric Ligand	2RH1-β₂-S-Carazolol 6PS3-β₂-S-Carvedilol 6PS5-β₂-S-Propranolol 3D4S-β₂-Timolol 3NY8-β₂-ICI118-551 3NY9-β₂-ICI118-551 6PRZ-β₂-S-Alprenolol
47.06	Consensus	beta_off	Orthosteric Ligand	beta1_off beta2_off
47.06	Consensus	gi_adrenergic	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
47.06	Consensus	gq_muscarinic	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
47.06	Consensus	m1_on	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
47.06	Consensus	m2_off	Orthosteric Ligand	5ZKC-M₂-N-Methyl-Scopolamine 5ZK3-M₂-3-quinuclidinyl-benzilate 5ZKB-M₂-AF-DX 384
47.06	Consensus	m3_on	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.06	Consensus	m3_on_gp	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.06	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
47.06	Consensus	trace-amine_on	Orthosteric Ligand	ta1_on
46.67	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
46.67	Single	4S0V	Suvorexant	4S0V-OX₂-Suvorexant
46.67	Single	5WS3	EMPA	5WS3-OX₂-EMPA
46.67	Single	6AKX	A4R	6AKX-CCR5-A4R
46.67	Single	6AKY	Maraviroc	6AKY-CCR5-Maraviroc
46.67	Single	6KUY	PubChem 145704643	6KUY-α_2a-PubChem 145704643
46.67	Single	6TOD	EMPA	6TOD-OX₁-EMPA-Na
46.67	Single	6TPJ	Suvorexant	6TPJ-OX₂-Suvorexant
46.67	Single	7XRR	Lemborexant	7XRR-OX₂-Lemborexant
46.67	Single	7YM8	Oxymetazoline	7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
46.67	Single	7YMH	Norepinephrine	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
46.67	Single	8GGA	Constrained Epinephrine	8GGA-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
46.67	Single	8GGC	Constrained Epinephrine	8GGC-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
46.67	Single	8GGR	Constrained Epinephrine	8GGR-β₂-Constrained Epinephrine
46.67	Single	8GGW	Constrained Epinephrine	8GGW-β₂-Constrained Epinephrine
46.67	Single	8GGZ	Constrained Epinephrine	8GGZ-β₂-Constrained Epinephrine
46.67	Single	8GH0	Constrained Epinephrine	8GH0-β₂-Constrained Epinephrine
46.67	Single	8IW4	Spermidine	8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
46.67	Single	8IWE	Spermidine	8IWE-TA9-Spermidine
46.67	Single	8WC3	SEP-363856	8WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
46.67	Single	8WC4	ZH8651	8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
46.67	Single	8WCA	2-Phenylethylamine	8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
46.67	Single	8YUV	Immepip	8YUV-H₃-Immepip-Gi1/β1/γ2
46.67	Single	9KPE	SA0	9KPE-TAS2R16-SA0-Gi1/β1/γ2
46.67	Single	9MQJ	Isoquinuclidine	9MQJ-μ-Isoquinuclidine
46.67	Consensus	histamine_on	Orthosteric Ligand	h1_on h2_on h3_on h4_on
46.67	Consensus	histamine_on_gp	Orthosteric Ligand	h1_on_gp h2_on_gp h3_on_gp h4_on_gp
46.67	Consensus	orexin_off	Orthosteric Ligand	ox2_off ox1_off
46.67	Consensus	ox1_off	Orthosteric Ligand	6TP6-OX₁-Filorexant 6TP4-OX₁-ACT-462206 6V9S-OX₁-GTPL11403 6TOT-OX₁-Lemborexant 6TP3-OX₁-Nemorexant 6TQ6-OX₁-PubChem 145714283 6TQ9-OX₁-SB-408124 4ZJC-OX₁-SB-674042 4ZJ8-OX₁-Suvorexant 6TOD-OX₁-EMPA-Na 6TOS-OX₁-GSK1059865-Na 6TQ4-OX₁-PubChem 16046844-Na
46.67	Consensus	ox2_off	Orthosteric Ligand	5WQC-OX₂-EMPA 6TPN-OX₂-HTL6641 7XRR-OX₂-Lemborexant 6TPJ-OX₂-Suvorexant
46.67	Consensus	s1p1_off	Orthosteric Ligand	3V2W-S1P₁-PubChem 51892645
46.15	Single	3OE8	IT1t	3OE8-CXCR4-IT1t
46.15	Single	8DPH	Lorcaserin	8DPH-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.15	Single	8IWM	2-Phenylethylamine	8IWM-TA9-2-Phenylethylamine
46.15	Single	8WC5	Tetramethylammonium Ion	8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
45.83	Consensus	opioid_on_gp	Orthosteric Ligand	mop_on_gp nop_on_gp dop_on_gp kop_on_gp
45.45	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/β1/γ2
45.45	Single	8XGU	TAK448	8XGU-Kiss1-TAK448-Gi1/β1/γ2
45.45	Single	9B54	A1AIW	9B54-CB₁-A1AIW-Gi1/β1/γ2
45.00	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
45.00	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/β1/γ2
45.00	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/β1/γ2
45.00	Single	8Y72	Peptide	8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
45.00	Single	9MD1	Buspirone	9MD1-5-HT_1A-Buspirone-Gz/β1/γ2
45.00	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
45.00	Consensus	ox2_on_gp	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
45.00	Consensus	s1p_on	Orthosteric Ligand	s1p1_on s1p3_on s1p5_on
45.00	Consensus	s1p_on_gp	Orthosteric Ligand	s1p1_on_gp s1p3_on_gp s1p5_on_gp
44.44	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
44.44	Single	5D5A	S-Carazolol	5D5A-β₂-S-Carazolol
44.44	Single	5D5B	S-Carazolol	5D5B-β₂-S-Carazolol
44.44	Single	6DDE	Damgo	6DDE-μ-Damgo-Gi1/β1/γ2
44.44	Single	6H7J	Isoprenaline	6H7J-β₁-Isoprenaline
44.44	Single	6N48	BI167107	6N48-β₂-BI167107-PubChem 138454256
44.44	Single	6OIJ	Iperoxo	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
44.44	Single	7E2Z	Aripiprazole	7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2
44.44	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
44.44	Single	7EW7	SEW2871	7EW7-S1P₁-SEW2871-Gi1/β1/γ2
44.44	Single	7JJO	Isoprenaline	7JJO-β₁-Isoprenaline-Gs/β1/γ2
44.44	Single	7TRQ	Iperoxo	7TRQ-M₄-Iperoxo-VU0467154-Gi1/β1/γ2
44.44	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/β1/γ2
44.44	Single	7W6P	N-pyridin-4-ylisoquinolin-4-amine	7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
44.44	Single	7W7E	PubChem 164946676	7W7E-α_2a-PubChem 164946676-Go/β1/γ2
44.44	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/β1/γ2
44.44	Single	8EA0	Iperoxo	8EA0-M₃-Iperoxo
44.44	Single	8IRR	Rotigotine	8IRR-D₁-Rotigotine-Gs/β1/γ2
44.44	Single	8IRV	Rotigotine	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
44.44	Single	8JT6	(R)-IHCH-7179	8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2
44.44	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/β1/γ2
44.44	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/β1/γ2
44.44	Single	8XZI	CMF-019	8XZI-Apelin-CMF-019-Gi1/β1/γ2
44.44	Single	9BJK	Naloxone	9BJK-μ-Naloxone-NAM
44.44	Single	9IJD	Carazolol	9IJD-β₃-Carazolol-chim(NtGi1-Gs)/β1/γ2
44.44	Consensus	5ht_off	Orthosteric Ligand	5ht2_off 5ht1_off
44.44	Consensus	amine_on_gp	Orthosteric Ligand	5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
44.44	Consensus	beta1_off	Orthosteric Ligand	2VT4-β₁-Cyanopindolol 2YCW-β₁-S-Carazolol 2YCZ-β₁-Iodocyanopindolol 5A8E-β₁-7-Methylcyanopindolol-Na 3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
44.44	Consensus	beta2_on	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2
44.44	Consensus	beta2_on_gp	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2
44.44	Consensus	class-a_off	Orthosteric Ligand	sensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
44.44	Consensus	d1_on_gp	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
44.44	Consensus	d5_on_gp	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
44.44	Consensus	gi_5ht	Orthosteric Ligand	8FYT-5-HT_1A-LSD-Gi1/β1/γ1 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT_1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2 7E32-5-HT_1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT₄-Serotonin-Gi1/β1/γ2 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2
44.44	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2
44.44	Consensus	m1_on_gp	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
44.44	Consensus	m3_off	Orthosteric Ligand	4U15-M₃-Tiotropium 4U16-M₃-N-Methyl-Scopolamine 5ZHP-M₃-PubChem 134828589
44.44	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
44.44	Consensus	s1p5_on_gp	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
44.44	Consensus	ta1_on_gp	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
44.44	Consensus	trace-amine_on_gp	Orthosteric Ligand	ta1_on_gp
44.00	Single	8ZH8	QRF-Amide	8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
43.75	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
43.75	Single	4DKL	Beta-Funaltrexamine	4DKL-μ-β-Funaltrexamine
43.75	Single	4LDO	L-Epinephrine	4LDO-β₂-L-Epinephrine
43.75	Single	4MBS	Maraviroc	4MBS-CCR5-Maraviroc
43.75	Single	4N6H	Naltrindole	4N6H-δ-Naltrindole-Na
43.75	Single	6K41	Dexmedetomidine	6K41-α_2b-Dexmedetomidine-Go/β1/γ2
43.75	Single	6PS0	S-Carazolol	6PS0-β₂-S-Carazolol
43.75	Single	6PS4	ICI118-551	6PS4-β₂-ICI118-551
43.75	Single	6TP3	Nemorexant	6TP3-OX₁-Nemorexant
43.75	Single	6TPN	HTL6641	6TPN-OX₂-HTL6641
43.75	Single	6V9S	GTPL11403	6V9S-OX₁-GTPL11403
43.75	Single	6VI4	JDTic	6VI4-κ-JDTic
43.75	Single	6WJC	Atropine	6WJC-M₁-Atropine-Muscarinic toxin 7
43.75	Single	7CMU	Pramipexole	7CMU-D₃-Pramipexole-Gi1/β1/γ2
43.75	Single	7DHI	Salbutamol	7DHI-β₂-Salbutamol-Gs/β1/γ2
43.75	Single	7E33	BRL-54443	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2
43.75	Single	7EJ8	Brimonidine	7EJ8-α_2a-Brimonidine-Go/β1/γ2
43.75	Single	7F61	PF-03654746	7F61-H₃-PF-03654746
43.75	Single	7RAN	PubChem 164575847	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
43.75	Single	7UM7	Methylergometrine	7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
43.75	Single	7YK6	PubChem 138319674	7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
43.75	Single	8GE1	Constrained Epinephrine	8GE1-β₂-Constrained Epinephrine-Gs/β1/γ2
43.75	Single	8GE4	Constrained Epinephrine	8GE4-β₂-Constrained Epinephrine-Gs/β1/γ2
43.75	Single	8GE6	Constrained Epinephrine	8GE6-β₂-Constrained Epinephrine-Gs/β1/γ2
43.75	Single	8GE7	Constrained Epinephrine	8GE7-β₂-Constrained Epinephrine-Gs/β1/γ2
43.75	Single	8GE8	Constrained Epinephrine	8GE8-β₂-Constrained Epinephrine-Gs/β1/γ2
43.75	Single	8GEF	Constrained Epinephrine	8GEF-β₂-Constrained Epinephrine-Gs/β1/γ2
43.75	Single	8GGQ	Constrained Epinephrine	8GGQ-β₂-Constrained Epinephrine
43.75	Single	8GGS	Constrained Epinephrine	8GGS-β₂-Constrained Epinephrine
43.75	Single	8GGT	Constrained Epinephrine	8GGT-β₂-Constrained Epinephrine
43.75	Single	8GGV	Constrained Epinephrine	8GGV-β₂-Constrained Epinephrine
43.75	Single	8GGX	Constrained Epinephrine	8GGX-β₂-Constrained Epinephrine
43.75	Single	8IHK	Acifran	8IHK-HCA₃-Acifran
43.75	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
43.75	Single	8JLN	T1AM	8JLN-TA1-T1AM-Gs/β1/γ2
43.75	Single	8JLQ	Fenoldopam	8JLQ-TA1-Fenoldopam-Gs/β1/γ2
43.75	Single	8K9K	Damgo	8K9K-μ-Damgo-Gi3/β1/γ1
43.75	Single	8U02	L-Dopamine	8U02-D₂-L-Dopamine-Go/β1/γ2
43.75	Single	8UO0	Constrained Epinephrine	8UO0-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
43.75	Single	8W88	SEP-363856	8W88-TA1-SEP-363856-Gs/β1/γ2
43.75	Single	8YN3	Histamine	8YN3-H₂-Histamine-Gs/β1/γ2
43.75	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
43.75	Single	9CBL	Epinephrine	9CBL-α_2a-Epinephrine-Gi1/β1/γ2
43.75	Single	9MQI	Isoquinuclidine	9MQI-μ-Isoquinuclidine
43.75	Consensus	d3_on	Orthosteric Ligand	7CMV-D₃-PD128907-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2
43.75	Consensus	d3_on_gp	Orthosteric Ligand	7CMV-D₃-PD128907-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2
43.75	Consensus	nop_off	Orthosteric Ligand	4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
42.86	Single	4AMJ	S-Carvedilol	4AMJ-β₁-S-Carvedilol
42.86	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/β1/γ2
42.86	Single	8FYL	Vilazodone	8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
42.86	Single	8ITF	DMCHA	8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
42.86	Single	8JXT	Histamine	8JXT-H₄-Histamine-PO4-Gi1/β1/γ2
42.86	Single	8POK	Histamine	8POK-H₂-Histamine-Gs/β1/γ2
42.86	Single	8WC9	ZH8651	8WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86	Single	8WDT	photoNECA	8WDT-A_2A-photoNECA
42.86	Consensus	class-a_on_gp	Orthosteric Ligand	sensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
42.86	Consensus	h2_on_gp	Orthosteric Ligand	8POK-H₂-Histamine-Gs/β1/γ2
42.86	Consensus	mop_off	Orthosteric Ligand	4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
42.11	Single	3D4S	Timolol	3D4S-β₂-Timolol
42.11	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
42.11	Single	4LDE	BI167107	4LDE-β₂-BI167107
42.11	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
42.11	Single	5F8U	Cyanopindolol	5F8U-β₁-Cyanopindolol
42.11	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
42.11	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
42.11	Single	6H7N	S-Xamoterol	6H7N-β₁-S-Xamoterol
42.11	Single	6H7O	Cyanopindolol	6H7O-β₁-Cyanopindolol
42.11	Single	7K15	MKD046	7K15-BLT₁-MKD046-Na
42.11	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
42.11	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
42.11	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/β1/γ2
42.11	Single	8E9W	2-Deoxycytidine	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.11	Single	8FYE	4-F,5-MeO-PyrT	8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
42.11	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/β1/γ2
42.11	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/β1/γ2
42.11	Single	8XYI	VUF10661	8XYI-CXCR3-VUF10661
42.11	Single	9EBI	Piclidenoson	9EBI-A_3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
42.11	Single	9GYO	P395	9GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
42.11	Single	9M4Q	Doxazosin	9M4Q-Alpha1A-Doxazosin
42.11	Consensus	5ht1a_on	Orthosteric Ligand	8FYT-5-HT_1A-LSD-Gi1/β1/γ1 7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
42.11	Consensus	5ht1a_on_gp	Orthosteric Ligand	8FYT-5-HT_1A-LSD-Gi1/β1/γ1 8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
42.11	Consensus	gi_muscarinic	Orthosteric Ligand	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2
42.11	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
42.11	Consensus	s1p1_on	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
42.11	Consensus	s1p1_on_gp	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
41.67	Single	8XGO	TAK448	8XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
41.67	Single	8ZRT	ET-1	8ZRT-ET_B-ET-1
41.67	Consensus	opioid_on	Orthosteric Ligand	mop_on nop_on dop_on kop_on
41.18	Single	3NYA	S-Alprenolol	3NYA-β₂-S-Alprenolol
41.18	Single	3ZPQ	4-(piperazin-1- yl)-1H-indole	3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na
41.18	Single	3ZPR	4-methyl-2-(piperazin-1-yl)	3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
41.18	Single	4DAJ	Tiotropium	4DAJ-M₃-Tiotropium
41.18	Single	4MQS	Iperoxo	4MQS-M₂-Iperoxo
41.18	Single	4U14	Tiotropium	4U14-M₃-Tiotropium
41.18	Single	5DSG	Tiotropium	5DSG-M₄-Tiotropium
41.18	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
41.18	Single	6H7M	Salbutamol	6H7M-β₁-Salbutamol
41.18	Single	6K42	Dexmedetomidine	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
41.18	Single	6PS2	S-Alprenolol	6PS2-β₂-S-Alprenolol
41.18	Single	6WHA	DB13948	6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.18	Single	7BTS	L-Epinephrine	7BTS-β₁-L-Epinephrine
41.18	Single	7BU6	L-Norepinephrine	7BU6-β₁-L-Norepinephrine
41.18	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/β1/γ2
41.18	Single	7E32	Serotonin	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
41.18	Single	7F83	PF-05190457	7F83-Ghrelin-PF-05190457
41.18	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/β1/γ2
41.18	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
41.18	Single	7S0G	Isoprenaline	7S0G-β₁-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
41.18	Single	7T2G	Mitragynine Pseudoindoxyl	7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
41.18	Single	7T6V	fMLFII	7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
41.18	Single	7TRP	Iperoxo	7TRP-M₄-Iperoxo-LY2033298-Gi1/β1/γ2
41.18	Single	7VKT	LTB4	7VKT-BLT₁-LTB4-Gi1/β1/γ2
41.18	Single	7WC7	Lisuride	7WC7-5-HT_2A-Lisuride
41.18	Single	7XJH	Isoproterenol	7XJH-β₃-Isoproterenol-Gs/β1/γ2
41.18	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
41.18	Single	8FY8	5-MeO-DMT	8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1
41.18	Single	8GE3	Constrained Epinephrine	8GE3-β₂-Constrained Epinephrine-Gs/β1/γ2
41.18	Single	8GE9	Constrained Epinephrine	8GE9-β₂-Constrained Epinephrine-Gs/β1/γ2
41.18	Single	8GEC	Constrained Epinephrine	8GEC-β₂-Constrained Epinephrine-Gs/β1/γ2
41.18	Single	8GEE	Constrained Epinephrine	8GEE-β₂-Constrained Epinephrine-Gs/β1/γ2
41.18	Single	8GFV	Constrained Epinephrine	8GFV-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18	Single	8GFW	Constrained Epinephrine	8GFW-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18	Single	8GFX	Constrained Epinephrine	8GFX-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18	Single	8GFZ	Constrained Epinephrine	8GFZ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18	Single	8GG0	Constrained Epinephrine	8GG0-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18	Single	8GG1	Constrained Epinephrine	8GG1-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18	Single	8GG3	Constrained Epinephrine	8GG3-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18	Single	8GG4	Constrained Epinephrine	8GG4-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18	Single	8GG6	Constrained Epinephrine	8GG6-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18	Single	8GG9	Constrained Epinephrine	8GG9-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18	Single	8GGI	Constrained Epinephrine	8GGI-β₂-Constrained Epinephrine
41.18	Single	8GGJ	Constrained Epinephrine	8GGJ-β₂-Constrained Epinephrine
41.18	Single	8GGK	Constrained Epinephrine	8GGK-β₂-Constrained Epinephrine
41.18	Single	8GGN	Constrained Epinephrine	8GGN-β₂-Constrained Epinephrine
41.18	Single	8GGO	Constrained Epinephrine	8GGO-β₂-Constrained Epinephrine
41.18	Single	8GGU	Constrained Epinephrine	8GGU-β₂-Constrained Epinephrine
41.18	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/β1/γ2
41.18	Single	8JJO	Alprenolol	8JJO-β₂-Alprenolol
41.18	Single	8K5D	GSK256073	8K5D-HCA₂-GSK256073
41.18	Single	8UGY	Mianserin	8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1
41.18	Single	8UH3	Setiptiline	8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
41.18	Single	8UNQ	Constrained Epinephrine	8UNQ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18	Single	8UNV	Constrained Epinephrine	8UNV-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18	Single	8UNY	Constrained Epinephrine	8UNY-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18	Single	8UNZ	Constrained Epinephrine	8UNZ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18	Single	8UO2	Constrained Epinephrine	8UO2-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18	Single	8VVG	GB18	8VVG-κ-GB18-Gi1/β1/γ2
41.18	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
41.18	Single	8WC7	ZH8667	8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
41.18	Single	8X64	Desloratadine	8X64-H₁-Desloratadine
41.18	Single	8YN8	Proxyfan	8YN8-H₃-Proxyfan-Go/β1/γ2
41.18	Single	9CHX	S-Carazolol	9CHX-β₂-S-Carazolol
41.18	Single	9PQD	(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole	9PQD-α_2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
41.18	Consensus	5ht1d_on	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
41.18	Consensus	5ht1d_on_gp	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
41.18	Consensus	adrenergic_on	Orthosteric Ligand	alpha_on beta_on
41.18	Consensus	alicarboxylic_on_gp	Orthosteric Ligand	succinate_on_gp hca_on_gp
41.18	Consensus	alpha2_on	Orthosteric Ligand	alpha2b_on
41.18	Consensus	alpha2_on_gp	Orthosteric Ligand	alpha2b_on_gp
41.18	Consensus	alpha2b_on	Orthosteric Ligand	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
41.18	Consensus	alpha2b_on_gp	Orthosteric Ligand	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
41.18	Consensus	blt1_on	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
41.18	Consensus	blt1_on_gp	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
41.18	Consensus	blt_on	Orthosteric Ligand	blt1_on
41.18	Consensus	blt_on_gp	Orthosteric Ligand	blt1_on_gp
41.18	Consensus	d5_on	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
41.18	Consensus	dopamine_on	Orthosteric Ligand	d2_on d1_on d3_on d4_on d5_on
41.18	Consensus	dopamine_on_gp	Orthosteric Ligand	d2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
41.18	Consensus	gi_alicarboxylic	Orthosteric Ligand	gi_hca gi_succinate
41.18	Consensus	gi_leukotriene	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
41.18	Consensus	gq_amine	Orthosteric Ligand	gq_muscarinic gq_histamine
41.18	Consensus	leukotriene_on	Orthosteric Ligand	blt_on
41.18	Consensus	leukotriene_on_gp	Orthosteric Ligand	blt_on_gp
41.18	Consensus	m4_off	Orthosteric Ligand	5DSG-M₄-Tiotropium
40.91	Consensus	gq_class-a	Orthosteric Ligand	gq_peptide gq_amine gq_nucleotide
40.74	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
40.74	Consensus	bb2_on_gp	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
40.74	Consensus	bombesin_on	Orthosteric Ligand	bb2_on
40.74	Consensus	bombesin_on_gp	Orthosteric Ligand	bb2_on_gp
40.74	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
40.00	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
40.00	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
40.00	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
40.00	Single	6BQH	Ritanserin	6BQH-5-HT_2C-Ritanserin
40.00	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
40.00	Single	6K1Q	IRL2500	6K1Q-ET_B-IRL2500
40.00	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2
40.00	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/β1/γ2
40.00	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
40.00	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/β1/γ2
40.00	Single	7XK2	MK6892	7XK2-HCA₂-MK6892-Gi1/β1/γ2
40.00	Single	7XZ6	APD668	7XZ6-GPR119-APD668-Gs/β1/γ2
40.00	Single	8GGY	Constrained Epinephrine	8GGY-β₂-Constrained Epinephrine
40.00	Single	8I95	EP54	8I95-C3a_B-EP54-Go/β1/γ2
40.00	Single	8IHI	Acifran	8IHI-HCA₂-Acifran-Gi1/β1/γ2
40.00	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/β1/γ2
40.00	Single	8J19	LY237	8J19-GPR84-LY237-Gi1/β1/γ2
40.00	Single	8JLO	Ulotaront	8JLO-TA1-Ulotaront-Gs/β1/γ2
40.00	Single	8UO3	Constrained Epinephrine	8UO3-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
40.00	Single	8W89	PEA	8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
40.00	Single	8YKW	Succinic acid	8YKW-Succinate-Succinic acid-Gi1/β1/γ1
40.00	Single	8YN4	Histamine	8YN4-H₂-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.00	Single	8ZSV	RO5263397	8ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
40.00	Single	8ZWG	JR14a	8ZWG-C3a_B-JR14a-Gi1/β1/γ2
40.00	Single	9AS0	2-bromo-LSD	9AS0-5-HT_2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00	Single	9CGJ	C6-Quino	9CGJ-δ-C6-Quino-Gi1/β1/γ2
40.00	Single	9EAI	Losartan	9EAI-AT₁-Losartan-Nanobody AT209
40.00	Single	9EPR	Retinal	9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
40.00	Single	9IJE	Epinephrine	9IJE-β₃-Epinephrine-chim(NtGi1-Gs)/β1/γ2
40.00	Single	9IXJ	Histamine	9IXJ-H₂-Histamine-Gs/β1/γ2
40.00	Single	9IZF	NKP	9IZF-LPA₁-NKP-Gi1/β1/γ2
40.00	Consensus	5ht2c_off	Orthosteric Ligand	6BQH-5-HT_2C-Ritanserin
40.00	Consensus	beta1_on	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
40.00	Consensus	beta1_on_gp	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
40.00	Consensus	peptide_off	Orthosteric Ligand	cck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
39.13	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
39.13	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/β1/γ2
39.13	Single	8XIQ	L796778	8XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
39.13	Single	8XIR	Pasireotide	8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
39.13	Consensus	peptide_offon	Orthosteric Ligand	peptide_off peptide_on
38.89	Single	2Y00	Dobutamine	2Y00-β₁-Dobutamine
38.89	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
38.89	Single	5JQH	S-Carazolol	5JQH-β₂-S-Carazolol
38.89	Single	5XPR	Bosentan	5XPR-ET_B-Bosentan
38.89	Single	5ZK3	3-quinuclidinyl-benzilate	5ZK3-M₂-3-quinuclidinyl-benzilate
38.89	Single	6KUW	PubChem 57213234	6KUW-α_2c-PubChem 57213234
38.89	Single	6OIK	Iperoxo	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
38.89	Single	6PS3	S-Carvedilol	6PS3-β₂-S-Carvedilol
38.89	Single	6PS6	Timolol	6PS6-β₂-Timolol
38.89	Single	7BVQ	S-Carazolol	7BVQ-β₁-S-Carazolol
38.89	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/β1/γ2
38.89	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
38.89	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-MIPS521-Gi2/β1/γ2
38.89	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
38.89	Single	7S0F	Isoprenaline	7S0F-β₁-Isoprenaline-Gi1/β1/γ2
38.89	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/β1/γ2
38.89	Single	7TRK	Iperoxo	7TRK-M₄-Iperoxo-Gi1/β1/γ2
38.89	Single	7WC6	LSD	7WC6-5-HT_2A-LSD
38.89	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.89	Single	7XK9	Constrained Isoproterenol	7XK9-β₂-Constrained Isoproterenol-Na
38.89	Single	7XKA	Constrained Epinephrine	7XKA-β₂-Constrained Epinephrine
38.89	Single	8GDZ	Constrained Epinephrine	8GDZ-β₂-Constrained Epinephrine-Gs/β1/γ2
38.89	Single	8GEB	Constrained Epinephrine	8GEB-β₂-Constrained Epinephrine-Gs/β1/γ2
38.89	Single	8GEG	Constrained Epinephrine	8GEG-β₂-Constrained Epinephrine-Gs/β1/γ2
38.89	Single	8GFY	Constrained Epinephrine	8GFY-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
38.89	Single	8GG2	Constrained Epinephrine	8GG2-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
38.89	Single	8GGB	Constrained Epinephrine	8GGB-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
38.89	Single	8HNL	PS372424	8HNL-CXCR3-PS372424-Gi1/β1/γ2
38.89	Single	8J18	(3R)-3-Hydroxydodecanoic acid	8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
38.89	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/β1/γ2
38.89	Single	8JXS	PF-6142	8JXS-D₁-PF-6142
38.89	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
38.89	Single	8TH4	Losartan	8TH4-AT₁-Losartan-AT118-L Nanobody
38.89	Single	8UNN	Constrained Epinephrine	8UNN-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
38.89	Single	8UNP	Constrained Epinephrine	8UNP-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
38.89	Single	8XYK	VUF10661	8XYK-CXCR3-VUF10661-Go/β1/γ2
38.89	Single	8YIC	SAR247799	8YIC-S1P₁-SAR247799-Gi1/β1/γ2
38.89	Single	8ZMF	A1L10	8ZMF-5-HT_2C-A1L10
38.89	Single	8ZRK	GSK-1292263	8ZRK-GPR119-GSK-1292263-Gs/β1/γ2
38.89	Single	9ARZ	2-bromo-LSD	9ARZ-5-HT_2A-2-bromo-LSD
38.89	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
38.89	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
38.89	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
38.89	Single	9DYD	Asenapine	9DYD-5-HT_1A-Asenapine-Go/β1/γ2
38.89	Single	9DYF	Asenapine	9DYF-5-HT_1A-Asenapine-Gi1/β1/γ2
38.89	Single	9EAH	Olmesartan	9EAH-AT₁-Olmesartan-Nanobody AT209
38.89	Single	9F33	FOB02-04A	9F33-D₃-FOB02-04A-Go/β1/γ2
38.89	Single	9HAP	Tolvaptan	9HAP-V₂-Tolvaptan
38.89	Single	9K07	DSO-5a	9K07-BB₃-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.89	Consensus	5ht1_on	Orthosteric Ligand	5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
38.89	Consensus	5ht1_on_gp	Orthosteric Ligand	5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
38.89	Consensus	5ht1e_on_gp	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
38.89	Consensus	5ht5_on_gp	Orthosteric Ligand	5ht5a_on_gp
38.89	Consensus	5ht5a_on_gp	Orthosteric Ligand	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
38.89	Consensus	adrenergic_off	Orthosteric Ligand	alpha_off beta_off
38.89	Consensus	adrenergic_on_gp	Orthosteric Ligand	alpha_on_gp beta_on_gp
38.89	Consensus	alpha2c_off	Orthosteric Ligand	6KUW-α_2c-PubChem 57213234
38.89	Consensus	cb2_on	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2
38.89	Consensus	cb2_on_gp	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2
38.89	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
38.89	Consensus	d2_on	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2
38.89	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
38.89	Consensus	h1_off	Orthosteric Ligand	8X63-H₁-Mepyramine 3RZE-H₁-Cidoxepin 8X5Y-H₁-Astemizole
38.89	Consensus	s1p_off	Orthosteric Ligand	s1p1_off s1p5_off
38.46	Single	3PXO	All-trans-Retinal	3PXO-Rhodopsin-All-trans-Retinal
38.46	Single	5DYS	All-trans-Retinal	5DYS-Rhodopsin-All-trans-Retinal
38.46	Single	9KDF	RES-701-3	9KDF-ET_B-RES-701-3
38.46	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
38.10	Single	3NY9	ICI118-551	3NY9-β₂-ICI118-551
38.10	Single	6PT3	DPI-287	6PT3-δ-DPI-287
38.10	Single	8X3L	XWD	8X3L-CB₂-XWD-Gi1/β1/γ2
38.10	Single	9CGK	C5-Quino	9CGK-δ-C5-Quino-Gi1/β1/γ2
38.10	Single	9IPV	JR14a	9IPV-C3a_B-JR14a-Gi1/β1/γ2
38.10	Single	9IZA	SCH900271	9IZA-HCA₂-SCH900271-Gi1/β1/γ2
38.10	Single	9V2N	Macimorelin	9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10	Consensus	cxcr3_on	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
38.10	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
37.50	Single	1GZM	11-cis-Retinal	1GZM-Rhodopsin-11-cis-Retinal
37.50	Single	2PED	9-cis-Retinal	2PED-Rhodopsin-9-cis-Retinal
37.50	Single	3C9L	11-cis-Retinal	3C9L-Rhodopsin-11-cis-Retinal
37.50	Single	6OBA	S-Alprenolol	6OBA-β₂-S-Alprenolol-GTPL11074
37.50	Single	7EJ0	L-Norepinephrine	7EJ0-α_2a-L-Norepinephrine-Go/β1/γ2
37.50	Single	7LD4	Adenosine	7LD4-A₁-Adenosine-Gi2/β1/γ2
37.50	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/β1/γ2
37.50	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/β1/γ2
37.50	Single	8JSO	AMPH	8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
37.50	Single	8TZQ	L-Dopamine	8TZQ-D₂-L-Dopamine-Go/β1/γ2
37.50	Single	8UNX	Constrained Epinephrine	8UNX-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50	Single	8WOG	Succinic acid	8WOG-Succinate-Succinic acid-Gi1/β1/γ2
37.50	Single	8XWQ	Endothelin-1	8XWQ-ET_B-Endothelin-1-Gi1/β1/γ2
37.50	Single	8YKX	Maleic acid	8YKX-Succinate-Maleic acid-Gi1/β1/γ1
37.50	Single	8ZBI	Somatostatin-14	8ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
37.50	Single	9BKK	Cholecystokinin-8	9BKK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50	Single	9EBH	Adenosine	9EBH-A_3A-Adenosine-Gi1/β1/γ2
37.50	Single	9EEA	Adenosine	9EEA-A_2A-Adenosine-Gs/β1/γ2
37.50	Single	9J5V	CpY	9J5V-LPA₁-CpY-Gi1/β1/γ2
37.50	Consensus	5ht1e_on	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
37.50	Consensus	a1_on	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
37.50	Consensus	a1_on_gp	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
37.50	Consensus	alpha2_off	Orthosteric Ligand	alpha2c_off
37.50	Consensus	cxcr3_on_gp	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
37.50	Consensus	gi_class-a	Orthosteric Ligand	gi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
37.50	Consensus	gi_succinate	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
37.50	Consensus	gq_histamine	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
37.50	Consensus	h1_on_gp	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
37.50	Consensus	peptide_offon_gp	Orthosteric Ligand	peptide_on_gp peptide_off
37.50	Consensus	sensory_offon	Orthosteric Ligand	sensory_off sensory_on
37.50	Consensus	sensory_offon_gp	Orthosteric Ligand	sensory_on_gp sensory_on
37.50	Consensus	succinate_on	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
37.50	Consensus	succinate_on_gp	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
37.04	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
36.84	Single	3SN6	BI167107	3SN6-β₂-BI167107-Gs/β1/γ2
36.84	Single	3UON	3-quinuclidinyl-benzilate	3UON-M₂-3-quinuclidinyl-benzilate
36.84	Single	4LDL	Hydroxybenzylisoproterenol	4LDL-β₂-Hydroxybenzylisoproterenol
36.84	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
36.84	Single	5V54	Methiothepin	5V54-5-HT_1B-Methiothepin
36.84	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
36.84	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
36.84	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
36.84	Single	6NI3	BI167107	6NI3-β₂-BI167107-Gs/β1/γ2
36.84	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/β1/γ2
36.84	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/β1/γ2
36.84	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/β1/γ2
36.84	Single	7WV9	CP55940	7WV9-CB₁-CP55940-ZCZ011-Gi2/β1/γ2
36.84	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2
36.84	Single	8HPT	C5a anaphylatoxin C-terminal peptide	8HPT-C5a₁-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
36.84	Single	8IHH	LUF6283	8IHH-HCA₂-LUF6283-Gi1/β1/γ2
36.84	Single	8UGW	PubChem 3086599	8UGW-A_2A-PubChem 3086599
36.84	Single	8WU1	PubChem 119025665	8WU1-CB₁-PubChem 119025665-Arrestin2
36.84	Single	8Y73	Peptide	8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
36.84	Single	9AS9	RS130-180	9AS9-5-HT_2A-RS130-180
36.84	Single	9ASA	RS130-180	9ASA-5-HT_2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
36.84	Single	9B65	KCA	9B65-CB₁-KCA-Gi1/β1/γ2
36.84	Single	9I54	A1IZV	9I54-D₁-A1IZV-Gs/β1/γ2
36.84	Single	9JMC	DS-3801b	9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
36.84	Consensus	5ht1_off	Orthosteric Ligand	5ht1b_off
36.84	Consensus	5ht1b_off	Orthosteric Ligand	5V54-5-HT_1B-Methiothepin
36.84	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 6KPG-CB₁-AM841-Gi1/β1/γ2
36.84	Consensus	gi_dopamine	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 7CMV-D₃-PD128907-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2
36.84	Consensus	gs_adrenergic	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2 7JJO-β₁-Isoprenaline-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2 8DCR-β₁-Dobutamine-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7DH5-β₃-Mirabegron-Gs/β1/γ2
36.36	Single	7QA8	Peptide	7QA8-STE2-Peptide
36.36	Single	7QA8	Peptide	7QA8-STE2-Peptide
36.36	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/β1/γ2
36.36	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
36.36	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/β1/γ2
36.36	Single	9M4T	Silodosin	9M4T-Alpha1A-Silodosin
36.36	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
36.36	Consensus	lpl_on_gp	Orthosteric Ligand	s1p_on_gp lpa_on_gp
35.71	Single	6TQ9	SB-408124	6TQ9-OX₁-SB-408124
35.71	Single	8GEI	Constrained Epinephrine	8GEI-β₂-Constrained Epinephrine-Gs/β1/γ2
35.71	Single	9CHU	Noradrenaline	9CHU-β₂-Noradrenaline
35.71	Consensus	gs_histamine	Orthosteric Ligand	8POK-H₂-Histamine-Gs/β1/γ2
35.71	Consensus	h2_on	Orthosteric Ligand	8POK-H₂-Histamine-Gs/β1/γ2
35.71	Consensus	opsins_on	Orthosteric Ligand	rhodopsin_on opsin1lw_on
35.71	Consensus	sensory_on	Orthosteric Ligand	opsins_on
35.29	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
35.29	Single	3OAX	11-cis-Retinal	3OAX-Rhodopsin-11-cis-Retinal
35.29	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
35.29	Single	4MQT	Iperoxo	4MQT-M₂-Iperoxo-LY2119620
35.29	Single	6A94	Zotepine	6A94-5-HT_2A-Zotepine
35.29	Single	6KUX	RS-79948	6KUX-α_2a-RS-79948
35.29	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
35.29	Single	6PS5	S-Propranolol	6PS5-β₂-S-Propranolol
35.29	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
35.29	Single	6WH4	Methiothepin	6WH4-5-HT_2A-Methiothepin
35.29	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/β1/γ2
35.29	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/β1/γ2
35.29	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/β1/γ2
35.29	Single	7F24	Dopamine	7F24-D₁-Dopamine-GDP-Gs/β1/γ2
35.29	Single	7UL3	Famotidine	7UL3-H₂-Famotidine
35.29	Single	7VUG	JNJ-63533054	7VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
35.29	Single	7WVU	fMLF	7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
35.29	Single	7ZBC	11-cis-Retinal	7ZBC-Rhodopsin-11-cis-Retinal
35.29	Single	7ZBE	11-cis-Retinal	7ZBE-Rhodopsin-11-cis-Retinal
35.29	Single	8DPG	Psilocin	8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.29	Single	8FCZ	11-cis-Retinal	8FCZ-Rhodopsin-11-cis-Retinal
35.29	Single	8GEA	Constrained Epinephrine	8GEA-β₂-Constrained Epinephrine-Gs/β1/γ2
35.29	Single	8GED	Constrained Epinephrine	8GED-β₂-Constrained Epinephrine-Gs/β1/γ2
35.29	Single	8GG5	Constrained Epinephrine	8GG5-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29	Single	8GG7	Constrained Epinephrine	8GG7-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29	Single	8GG8	Constrained Epinephrine	8GG8-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29	Single	8GGL	Constrained Epinephrine	8GGL-β₂-Constrained Epinephrine
35.29	Single	8GGM	Constrained Epinephrine	8GGM-β₂-Constrained Epinephrine
35.29	Single	8GGP	Constrained Epinephrine	8GGP-β₂-Constrained Epinephrine
35.29	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/β1/γ2
35.29	Single	8GUR	CP55,940	8GUR-CB₂-CP55,940-Gi1/β1/γ2
35.29	Single	8IY9	Niacin	8IY9-HCA₂-Niacin-Go/β1/γ2
35.29	Single	8JEI	3-nitro-4-(propylamino)benzoic acid	8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
35.29	Single	8JIM	MMF	8JIM-HCA₂-MMF-Gi1/β1/γ2
35.29	Single	8JSP	Ulotaront	8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2
35.29	Single	8K5C	Acipimox	8K5C-HCA₂-Acipimox
35.29	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/β1/γ2
35.29	Single	8UNL	Constrained Epinephrine	8UNL-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29	Single	8UNM	Constrained Epinephrine	8UNM-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29	Single	8UNO	Constrained Epinephrine	8UNO-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29	Single	8UNW	Constrained Epinephrine	8UNW-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29	Single	8V6U	PubChem 171392456	8V6U-5-HT_2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
35.29	Single	8W8B	SEP-363856	8W8B-5-HT_1A-SEP-363856-Gi1/β1/γ2
35.29	Single	8Y01	Retinal	8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
35.29	Single	8Y45	ADL5859	8Y45-δ-ADL5859-Gi2/β1/γ2
35.29	Single	8Y53	MK5046	8Y53-BB₃-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
35.29	Single	8YH2	Adenosine	8YH2-A_3A-Adenosine-Gi1/β1/γ2
35.29	Single	8YKV	PubChem 137553168	8YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
35.29	Single	8ZMG	Pimavanserin	8ZMG-5-HT_2A-Pimavanserin
35.29	Single	9AS5	Mescaline	9AS5-5-HT_2A-Mescaline
35.29	Single	9AS6	Mescaline	9AS6-5-HT_2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
35.29	Single	9JH3	CMF-019	9JH3-Apelin-CMF-019-Gi1/β1/γ2
35.29	Single	9JMD	Azithromycin	9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
35.29	Single	9LRD	Histamine	9LRD-H₁-Histamine-Gi1/β1/γ2
35.29	Consensus	5ht2a_off	Orthosteric Ligand	6A94-5-HT_2A-Zotepine 6A93-5-HT_2A-Risperidone 7VOD-5-HT_2A-Cariprazine 7WC8-5-HT_2A-Lumateperone 8JT8-5-HT_2A-(R)-IHCH-7179
35.29	Consensus	5ht_on_gp	Orthosteric Ligand	5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
35.29	Consensus	at1_off	Orthosteric Ligand	4YAY-AT₁-ZD-7155 4ZUD-AT₁-Olmesartan
35.29	Consensus	hca_on	Orthosteric Ligand	hca2_on
35.00	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
35.00	Single	6DRY	Methylergonovine	6DRY-5-HT_2B-Methylergonovine
35.00	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/β1/γ2
35.00	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/β1/γ2
35.00	Single	7EPE	NAM563	7EPE-mGlu2; mGlu2-NAM563
35.00	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/β1/γ2
35.00	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
35.00	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
35.00	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
35.00	Single	7WCN	AR231453	7WCN-GPR119-AR231453-Gs/β1/γ2
35.00	Single	8I9A	EP54	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00	Single	8IYW	GSK256073	8IYW-HCA₂-GSK256073-Go/β1/γ2
35.00	Single	8JJ8	Formoterol	8JJ8-β₂-Formoterol
35.00	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
35.00	Single	8JWZ	AB928	8JWZ-A_2A-AB928-Na
35.00	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/β1/γ2
35.00	Single	9DGI	Z8526711350	9DGI-CB₁-Z8526711350
35.00	Single	9IZH	LPA	9IZH-LPA₁-LPA-chim(NtGi2-G13)/β1/γ2
35.00	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
35.00	Consensus	5ht1f_on_gp	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
35.00	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
35.00	Consensus	beta3_on_gp	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
35.00	Consensus	beta_on	Orthosteric Ligand	beta1_on beta2_on beta3_on
35.00	Consensus	beta_on_gp	Orthosteric Ligand	beta1_on_gp beta2_on_gp beta3_on_gp
35.00	Consensus	cannabinoid_on	Orthosteric Ligand	cb2_on cb1_on
35.00	Consensus	cannabinoid_on_gp	Orthosteric Ligand	cb2_on_gp cb1_on_gp
35.00	Consensus	d2_on_gp	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2
35.00	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
35.00	Consensus	leukotriene_off	Orthosteric Ligand	blt_off cyslt_off
35.00	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z35-LPA₁-ONO-9910539 4Z34-LPA₁-ONO-9780307
35.00	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
35.00	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
35.00	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
35.00	Consensus	m4_on_gp	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
35.00	Consensus	nk1_off	Orthosteric Ligand	6HLP-NK₁-Netupitant 6HLO-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
35.00	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
34.78	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
34.78	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
34.78	Single	6DO1	Angiotensin-like peptide S1I8	6DO1-AT₁-Angiotensin-like peptide S1I8
34.78	Single	7DDZ	JNJ-31020028	7DDZ-Y₂-JNJ-31020028
34.78	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/β1/γ2
34.78	Single	9IK8	SST analogue	9IK8-SST1-SST analogue-Gi1/β1/γ2
34.78	Consensus	dop_on_gp	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
34.78	Consensus	npy2_off	Orthosteric Ligand	7DDZ-Y₂-JNJ-31020028
34.78	Consensus	sst4_on	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
34.78	Consensus	sst4_on_gp	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
34.62	Single	8XVE	BQ3020	8XVE-ET_B-BQ3020-chim(Gs-CtGq)/β1/γ2
34.62	Single	9KFK	Relaxin-3	9KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
34.62	Consensus	gi_peptide	Orthosteric Ligand	gi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
33.33	Single	1HZX	11-cis-Retinal	1HZX-Rhodopsin-11-cis-Retinal
33.33	Single	2J4Y	11-cis-Retinal	2J4Y-Rhodopsin-11-cis-Retinal
33.33	Single	2VT4	Cyanopindolol	2VT4-β₁-Cyanopindolol
33.33	Single	2Y01	Dobutamine	2Y01-β₁-Dobutamine
33.33	Single	2YCY	Cyanopindolol	2YCY-β₁-Cyanopindolol
33.33	Single	3C9M	11-cis-Retinal	3C9M-Rhodopsin-11-cis-Retinal
33.33	Single	3OE6	IT1t	3OE6-CXCR4-IT1t
33.33	Single	3PQR	All-trans-Retinal	3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
33.33	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
33.33	Single	4X1H	Nonyl-Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
33.33	Single	4YAY	ZD-7155	4YAY-AT₁-ZD-7155
33.33	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
33.33	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
33.33	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
33.33	Single	6DRX	Lisuride	6DRX-5-HT_2B-Lisuride
33.33	Single	6DRZ	Methysergide	6DRZ-5-HT_2B-Methysergide
33.33	Single	6FUF	All-trans-Retinal	6FUF-Rhodopsin-All-trans-Retinal-Go
33.33	Single	6GPS	MK0812	6GPS-CCR2-MK0812
33.33	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
33.33	Single	6PRZ	S-Alprenolol	6PRZ-β₂-S-Alprenolol
33.33	Single	6PS1	Timolol	6PS1-β₂-Timolol
33.33	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
33.33	Single	7BU7	BI167107	7BU7-β₁-BI167107
33.33	Single	7F23	Dopamine	7F23-D₁-Dopamine-GDP-Gs/β1/γ2
33.33	Single	7JOZ	VFP	7JOZ-D₁-VFP-Gs/β1/γ2
33.33	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2
33.33	Single	7LJC	SKF-81297	7LJC-D₁-SKF-81297-Mevidalen-Gs/β1/γ2
33.33	Single	7MT8	All-trans-Retinal	7MT8-Rhodopsin-All-trans-Retinal-GRK1
33.33	Single	7UM5	5-CT	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/β1/γ2
33.33	Single	7UM6	Lisuride	7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2
33.33	Single	7V3Z	CP55940	7V3Z-CB₁-CP55940
33.33	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/β1/γ2
33.33	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
33.33	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/β1/γ2
33.33	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/β1/γ2
33.33	Single	7XTC	5-CT	7XTC-5-HT₇-5-CT-Gs/β1/γ2
33.33	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/β1/γ2
33.33	Single	8EFQ	Damgo	8EFQ-μ-Damgo-Gi1/β1/γ2
33.33	Single	8GAG	PubChem 170838490	8GAG-CB₁-PubChem 170838490-Gi1/β1/γ2
33.33	Single	8GEH	Constrained Epinephrine	8GEH-β₂-Constrained Epinephrine-Gs/β1/γ2
33.33	Single	8GGE	Constrained Epinephrine	8GGE-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33	Single	8GGF	Constrained Epinephrine	8GGF-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33	Single	8GH1	Constrained Epinephrine	8GH1-β₂-Constrained Epinephrine
33.33	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/β1/γ2
33.33	Single	8I7V	Acipimox	8I7V-HCA₂-Acipimox-Gi1/β1/γ2
33.33	Single	8J6P	Niacin	8J6P-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
33.33	Single	8J6Q	Beta-Hydroxybutyrate	8J6Q-HCA₂-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
33.33	Single	8JD0	NAM563	8JD0-mGlu2; mGlu3-Glutamate-NAM563
33.33	Single	8JII	Niacin	8JII-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
33.33	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/β1/γ2
33.33	Single	8UNR	Constrained Epinephrine	8UNR-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33	Single	8UNU	Constrained Epinephrine	8UNU-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33	Single	8WC6	2-Phenylethylamine	8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
33.33	Single	8X63	Mepyramine	8X63-H₁-Mepyramine
33.33	Single	8XGS	Metastin	8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
33.33	Single	8XVJ	Macitentan	8XVJ-ET_A-Macitentan
33.33	Single	8XWP	Endothelin-1	8XWP-ET_B-Endothelin-1-Gi1/β1/γ2
33.33	Single	8ZQE	GPR15L(C11)	8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
33.33	Single	9AS1	DMT	9AS1-5-HT_2A-DMT
33.33	Single	9EPP	11,20-Ethanoretinal	9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
33.33	Single	9M54	Neuropeptide VF	9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
33.33	Consensus	5ht2_on	Orthosteric Ligand	5ht2b_on
33.33	Consensus	5ht2b_off	Orthosteric Ligand	6DRZ-5-HT_2B-Methysergide
33.33	Consensus	5ht2b_on	Orthosteric Ligand	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33	Consensus	5ht5_on	Orthosteric Ligand	5ht5a_on
33.33	Consensus	5ht5a_on	Orthosteric Ligand	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
33.33	Consensus	5ht7_on	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2
33.33	Consensus	5ht7_on_gp	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2
33.33	Consensus	adenosine_on_gp	Orthosteric Ligand	a1_on_gp a2_on_gp a3_on_gp
33.33	Consensus	alicarboxylic_off	Orthosteric Ligand	succinate_off
33.33	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
33.33	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
33.33	Consensus	cb1_on_gp	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
33.33	Consensus	ccr2_off	Orthosteric Ligand	6GPS-CCR2-MK0812
33.33	Consensus	gi_hca	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
33.33	Consensus	gi_somatostatin	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
33.33	Consensus	gs_class-a	Orthosteric Ligand	gs_peptide gs_nucleotide gs_amine
33.33	Consensus	hca2_on	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2
33.33	Consensus	hca2_on_gp	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
33.33	Consensus	hca_on_gp	Orthosteric Ligand	hca2_on_gp
33.33	Consensus	histamine_off	Orthosteric Ligand	h1_off
33.33	Consensus	opsins_on_gp	Orthosteric Ligand	rhodopsin_on_gp opsin1lw_on_gp
33.33	Consensus	peptide_on	Orthosteric Ligand	cck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
33.33	Consensus	peptide_on_gp	Orthosteric Ligand	cck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
33.33	Consensus	prostanoid_off	Orthosteric Ligand	ep_off dp_off
33.33	Consensus	rhodopsin_on	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
33.33	Consensus	sensory_on_gp	Orthosteric Ligand	opsins_on_gp
33.33	Consensus	somatostatin_on	Orthosteric Ligand	sst2_on sst4_on sst5_on
33.33	Consensus	somatostatin_on_gp	Orthosteric Ligand	sst2_on_gp sst4_on_gp sst5_on_gp
33.33	Consensus	succinate_off	Orthosteric Ligand	6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
32.00	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
32.00	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
32.00	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2
32.00	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/β1/γ2
32.00	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/β1/γ2
32.00	Consensus	angiotensin_on_gp	Orthosteric Ligand	at1_on_gp
32.00	Consensus	at1_on_gp	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
32.00	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
31.82	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
31.82	Single	7XN9	L-054,522	7XN9-SST2-L-054,522
31.82	Single	7XY6	BAY 60-6583	7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
31.82	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
31.82	Single	8QJ2	pN162	8QJ2-MC₄-pN162-Gs
31.82	Single	9IPY	JR14a	9IPY-C3a_B-JR14a
31.82	Single	9M0R	Neuropeptide VF	9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
31.82	Consensus	sst2_on	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
31.82	Consensus	sst2_on_gp	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
31.58	Single	5CGC	HTL14242	5CGC-mGlu₅-HTL14242
31.58	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
31.58	Single	5TVN	LSD	5TVN-5-HT_2B-LSD
31.58	Single	6D26	Fevipiprant	6D26-DP₂-Fevipiprant
31.58	Single	6E67	BI167107	6E67-β₂-BI167107-Gs(CT)
31.58	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/β1/γ1
31.58	Single	6GPX	MK0812	6GPX-CCR2-MK0812
31.58	Single	6HLP	Netupitant	6HLP-NK₁-Netupitant
31.58	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
31.58	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
31.58	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
31.58	Single	6ME8	2-Phenylmelatonin	6ME8-MT₂-2-Phenylmelatonin
31.58	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
31.58	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/β1/γ2
31.58	Single	7EUO	fMLF	7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
31.58	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
31.58	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
31.58	Single	7VOE	Aripiprazole	7VOE-5-HT_2A-Aripiprazole
31.58	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
31.58	Single	7WIG	L-054,264	7WIG-SST2-L-054,264-Gi1/β1/γ2
31.58	Single	8C9W	Etrumadenant	8C9W-A_2A-Etrumadenant
31.58	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
31.58	Single	8S4D	CMF-019	8S4D-Apelin-CMF-019
31.58	Single	8TF5	Oleic acid	8TF5-GPR6-Oleic acid
31.58	Single	8UUJ	FCH-2296413	8UUJ-HCA₂-FCH-2296413-Gi1/β1/γ2
31.58	Single	8X0C	VU0424465	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
31.58	Single	8X0D	VU0424465	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
31.58	Single	8X0D	VU0424465	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
31.58	Single	8YH0	NECA	8YH0-A_3A-NECA-Gi1/β1/γ2
31.58	Single	8YNS	SNAP-94847	8YNS-MCH1-SNAP-94847
31.58	Single	9CIB	FCH-2296413	9CIB-HCA₂-FCH-2296413
31.58	Consensus	blt1_off	Orthosteric Ligand	5X33-BLT₁-BIIL260 7K15-BLT₁-MKD046-Na
31.58	Consensus	blt_off	Orthosteric Ligand	blt1_off
31.58	Consensus	dp2_off	Orthosteric Ligand	6D26-DP₂-Fevipiprant
31.58	Consensus	dp_off	Orthosteric Ligand	dp2_off
31.58	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
31.58	Consensus	lipid_on_gp	Orthosteric Ligand	cannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
31.58	Consensus	rxfp4_on	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
31.58	Consensus	rxfp4_on_gp	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
31.25	Single	1L9H	11-cis-Retinal	1L9H-Rhodopsin-11-cis-Retinal
31.25	Single	1U19	11-cis-Retinal	1U19-Rhodopsin-11-cis-Retinal
31.25	Single	2G87	All-trans-Retinal	2G87-Rhodopsin-All-trans-Retinal
31.25	Single	2I35	11-cis-Retinal	2I35-Rhodopsin-11-cis-Retinal
31.25	Single	3OE9	IT1t	3OE9-CXCR4-IT1t
31.25	Single	3PBL	Eticlopride	3PBL-D₃-Eticlopride
31.25	Single	5TE5	20-Methanoretinal	5TE5-Rhodopsin-20-Methanoretinal
31.25	Single	6I9K	9-cis-Retinal	6I9K-Rhodopsin-9-cis-Retinal
31.25	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
31.25	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
31.25	Single	7DFL	Histamine	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
31.25	Single	7E2Y	Serotonin	7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2
31.25	Single	7SRQ	LSD	7SRQ-5-HT_2B-LSD
31.25	Single	7V68	Iperoxo	7V68-M₄-Iperoxo-LY2119620-Gi1/β1/γ2
31.25	Single	7XTA	Serotonin	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
31.25	Single	7XTB	Serotonin	7XTB-5-HT₆-Serotonin-Gs/β1/γ2
31.25	Single	8DPF	Lorcaserin	8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.25	Single	8EF6	Morphine	8EF6-μ-Morphine-Gi1/β1/γ2
31.25	Single	8H2G	Niacin	8H2G-HCA₂-Niacin-Gi1/β1/γ2
31.25	Single	8JPN	Cis-Epoxysuccinic acid	8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
31.25	Single	8K5B	Niacin	8K5B-HCA₂-Niacin
31.25	Single	8UO4	Constrained Epinephrine	8UO4-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
31.25	Single	8WP1	Cis-Epoxysuccinic acid	8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
31.25	Single	9AS2	DMT	9AS2-5-HT_2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25	Single	9IQT	Niacin	9IQT-HCA₂-Niacin-Gi1/β1/γ2
31.25	Single	9IZD	CHBA	9IZD-HCA₁-CHBA-Gi1/β1/γ2
31.25	Consensus	5ht4_on	Orthosteric Ligand	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
31.25	Consensus	5ht4_on_gp	Orthosteric Ligand	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
31.25	Consensus	d3_off	Orthosteric Ligand	3PBL-D₃-Eticlopride
31.25	Consensus	h1_on	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
31.03	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
31.03	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
30.77	Single	4A4M	All-trans-Retinal	4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
30.77	Single	5EN0	All-trans-Retinal	5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
30.77	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
30.77	Single	8XQE	Apelin-13	8XQE-Apelin-Apelin-13-Gi1/β1/γ2
30.77	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
30.77	Consensus	mc1_on_gp	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
30.77	Consensus	sst5_on_gp	Orthosteric Ligand	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.43	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
30.43	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
30.43	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
30.43	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/β1/γ2
30.43	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/β1/γ2
30.43	Single	8GHV	AMG315	8GHV-CB₁-AMG315-Gi1/β1/γ2
30.43	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/β1/γ2
30.43	Single	8WZ2	Orexigenic Neuropeptide QRFP	8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.43	Single	8ZBJ	Somatostatin-14	8ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
30.43	Single	9BUY	LM189	9BUY-β₂-LM189-Gi1/β1/γ2
30.43	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
30.43	Consensus	nop_on_gp	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
30.43	Consensus	sst5_on	Orthosteric Ligand	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.00	Single	3P0G	BI167107	3P0G-β₂-BI167107
30.00	Single	3PDS	Hydroxybenzylisoproterenol	3PDS-β₂-Hydroxybenzylisoproterenol
30.00	Single	5XR8	AM841	5XR8-CB₁-AM841
30.00	Single	5XRA	AM11542	5XRA-CB₁-AM11542
30.00	Single	6E59	L-760735	6E59-NK₁-L-760735
30.00	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
30.00	Single	6WGT	LSD	6WGT-5-HT_2A-LSD
30.00	Single	7B6W	Cyclazosin	7B6W-α_1b-Cyclazosin
30.00	Single	7EW4	CYM5541	7EW4-S1P₃-CYM5541-Gi1/β1/γ2
30.00	Single	7FEE	CP55940	7FEE-CB₁-CP55940-ZCZ011
30.00	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/β1/γ2
30.00	Single	7M8W	15r-Methyl-Prostaglandin D2	7M8W-DP₂-15r-Methyl-Prostaglandin D2-Na
30.00	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/β1/γ2
30.00	Single	7TUY	GSK682753A	7TUY-GPR183-GSK682753A
30.00	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/β1/γ2
30.00	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/β1/γ2
30.00	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
30.00	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/β1/γ2
30.00	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/β1/γ2
30.00	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/β1/γ2
30.00	Single	8JSR	Anamorelin	8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00	Single	8VVE	norBNI	8VVE-κ-norBNI-Gi1/β1/γ2
30.00	Single	8XIP	Pasireotide	8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.00	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
30.00	Single	8YH6	Namodenoson	8YH6-A_3A-Namodenoson-Gi1/β1/γ2
30.00	Single	8YNT	SNAP-94847	8YNT-MCH1-SNAP-94847
30.00	Single	8ZWF	JR14a	8ZWF-C3a_B-JR14a
30.00	Single	9EGO	YVF	9EGO-CB₁-YVF-Gi1/β1/γ2
30.00	Single	9IK9	SST analogue	9IK9-SST1-SST analogue-Gi1/β1/γ2
30.00	Single	9IZG	NKP	9IZG-LPA₁-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00	Consensus	a2_on	Orthosteric Ligand	a2b_on
30.00	Consensus	a2_on_gp	Orthosteric Ligand	a2b_on_gp
30.00	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
30.00	Consensus	a2b_on_gp	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
30.00	Consensus	endothelin_on_gp	Orthosteric Ligand	etb_on_gp eta_on_gp
30.00	Consensus	etb_on_gp	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
30.00	Consensus	gi_relaxin	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
30.00	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
30.00	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
30.00	Consensus	relaxin_on	Orthosteric Ligand	rxfp4_on
30.00	Consensus	relaxin_on_gp	Orthosteric Ligand	rxfp4_on_gp
30.00	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
29.63	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
29.63	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
29.41	Single	3ODU	IT1t	3ODU-CXCR4-IT1t
29.41	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/β1/γ2
29.41	Single	6OYA	All-trans-Retinal	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
29.41	Single	6RNK	NF-56-EJ40	6RNK-Succinate-NF-56-EJ40
29.41	Single	6TQ6	PubChem 145714283	6TQ6-OX₁-PubChem 145714283
29.41	Single	7DHR	Isoprenaline	7DHR-β₂-Isoprenaline-Gs/β1/γ2
29.41	Single	7F1O	Dopamine	7F1O-D₁-Dopamine-GDP; Mg-Gs/β1/γ2
29.41	Single	7LJD	Dopamine	7LJD-D₁-Dopamine-Mevidalen-Gs/β1/γ1
29.41	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
29.41	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
29.41	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
29.41	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
29.41	Single	7SRR	LSD	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.41	Single	7SRS	LSD	7SRS-5-HT_2B-LSD-Arrestin2
29.41	Single	7T6S	PubChem 24776341	7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
29.41	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
29.41	Single	7X2F	Dopamine	7X2F-D₁-Dopamine-Mevidalen-Gs/β1/γ2
29.41	Single	7X5H	5-CT	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2
29.41	Single	8A6C	All-trans-Retinal	8A6C-Rhodopsin-All-trans-Retinal
29.41	Single	8A6D	All-trans-Retinal	8A6D-Rhodopsin-All-trans-Retinal
29.41	Single	8A6E	All-trans-Retinal	8A6E-Rhodopsin-All-trans-Retinal
29.41	Single	8IJA	Niacin	8IJA-HCA₂-Niacin-Gi1/β1/γ2
29.41	Single	8IJB	Acipimox	8IJB-HCA₂-Acipimox-Gi1/β1/γ2
29.41	Single	8J6L	Niacin	8J6L-HCA₂-Niacin-Gi1/β1/γ2
29.41	Single	8JPP	Succinic acid	8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
29.41	Single	8UNS	Constrained Epinephrine	8UNS-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41	Single	8UNT	Constrained Epinephrine	8UNT-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41	Single	8UTD	MK1903	8UTD-HCA₂-MK1903-Gi1/β1/γ2
29.41	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
29.41	Single	8YUT	Amthamine	8YUT-H₂-Amthamine-Gs/β1/γ2
29.41	Single	8YYW	Alpha-ketoglutarate	8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
29.41	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
29.41	Single	9C2F	Ca; Ca; Tryptophan; '54149; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
29.41	Single	9K6L	SA0	9K6L-TAS2R16-SA0-Gi2/β1/γ2
29.41	Single	9LRB	Histamine	9LRB-H₁-Histamine-Gs/β1/γ2
29.41	Consensus	5ht2_on_gp	Orthosteric Ligand	5ht2b_on_gp
29.41	Consensus	5ht2b_on_gp	Orthosteric Ligand	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.41	Consensus	5ht_on	Orthosteric Ligand	5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
29.41	Consensus	angiotensin_off	Orthosteric Ligand	at1_off
29.41	Consensus	gs_5ht	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2 7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2 7XT8-5-HT₄-Serotonin-Gs/β1/γ2
29.41	Consensus	rhodopsin_off	Orthosteric Ligand	1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
29.41	Consensus	rhodopsin_on_gp	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
29.17	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
29.17	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/β1/γ2
29.17	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
29.17	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2
29.17	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/β1/γ2
29.17	Single	8SG1	Chemerin-9	8SG1-CML1-Chemerin-9-Gi1/β1/γ2
29.17	Single	9E82	SDF-1-beta	9E82-ACKR3-SDF-1-β-Arrestin2
29.17	Single	9IQV	Muscarinic toxin 3	9IQV-Alpha1A-Muscarinic toxin 3
29.17	Single	9KFI	Relaxin-3	9KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
29.17	Consensus	formylpeptide_on_gp	Orthosteric Ligand	fpr2-alx_on_gp fpr1-alx_on_gp
29.17	Consensus	ghrelin_on	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
29.17	Consensus	ghrelin_on_gp	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
29.17	Consensus	mc5_on	Orthosteric Ligand	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
28.57	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
28.57	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
28.57	Single	5X33	BIIL260	5X33-BLT₁-BIIL260
28.57	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/β1/γ2
28.57	Single	6KQI	CP55940	6KQI-CB₁-CP55940-Org27569
28.57	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
28.57	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/β1/γ2
28.57	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
28.57	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/β1/γ2
28.57	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
28.57	Single	7WCM	MBX-2982	7WCM-GPR119-MBX-2982-Gs/β1/γ2
28.57	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
28.57	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.57	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
28.57	Single	8ID9	Eicosapentaenoic acid	8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
28.57	Single	8J6D	EP141	8J6D-C3a_B-EP141-Go/β1/γ2
28.57	Single	8JD3	JNJ-40411813	8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
28.57	Single	8JWY	2-118	8JWY-A_2A-2-118
28.57	Single	8T3Q	Docosa-4,7,10,13,16,19-Hexaenoic acid	8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57	Single	8VHF	MBX-2982	8VHF-GPR119-MBX-2982-Gs/β1/γ2
28.57	Single	8W1V	PubChem 171716265	8W1V-β₂-PubChem 171716265
28.57	Single	9BJK	NAM	9BJK-μ-Naloxone-NAM
28.57	Single	9K26	PrRP31	9K26-PrRP-PrRP31-Gi1/β1/γ2
28.57	Consensus	c3a_on	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
28.57	Consensus	cb1_on	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
28.57	Consensus	lipid_offon	Orthosteric Ligand	lipid_off lipid_on
28.57	Consensus	lipid_offon_gp	Orthosteric Ligand	lipid_on_gp lipid_off
28.57	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.57	Consensus	trh_on_gp	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.00	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
28.00	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
28.00	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
27.78	Single	3RZE	Cidoxepin	3RZE-H₁-Cidoxepin
27.78	Single	3UZC	4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol	3UZC-A_2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
27.78	Single	4ZUD	Olmesartan	4ZUD-AT₁-Olmesartan
27.78	Single	6FFI	MMPEP	6FFI-mGlu₅-MMPEP
27.78	Single	6PT0	WIN 55212-2	6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2
27.78	Single	6TPK	Retosiban	6TPK-OT-Retosiban
27.78	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/β1/γ2
27.78	Single	7WC9	PubChem 162421364	7WC9-5-HT_2A-PubChem 162421364
27.78	Single	8JER	Acipimox	8JER-HCA₂-Acipimox-Go/β1/γ2
27.78	Single	8K9L	Damgo	8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
27.78	Single	8RLN	LUF5834	8RLN-A_2A-LUF5834
27.78	Single	8UO1	Constrained Epinephrine	8UO1-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
27.78	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
27.78	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78	Single	8Y6Y	GLPG0974	8Y6Y-FFA2-GLPG0974
27.78	Single	8ZPM	AMD070	8ZPM-CXCR4-AMD070
27.78	Single	9ARX	Serotonin	9ARX-5-HT_2A-Serotonin
27.78	Single	9AS3	LSD	9AS3-5-HT_2A-LSD
27.78	Single	9AS4	LSD	9AS4-5-HT_2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
27.78	Single	9EPQ	11,20-Ethanoretinal	9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
27.78	Single	9JKQ	METH	9JKQ-TA1-METH-Gs/β1/γ2
27.78	Single	9KPD	SA0	9KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
27.78	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on a3_on
27.78	Consensus	gi_adenosine	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2 8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
27.78	Consensus	opsins_off	Orthosteric Ligand	rhodopsin_off
27.78	Consensus	ot_off	Orthosteric Ligand	6TPK-OT-Retosiban
27.78	Consensus	sensory_off	Orthosteric Ligand	opsins_off
27.78	Consensus	vasop-oxy_off	Orthosteric Ligand	ot_off
27.59	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
27.59	Single	8WWN	MCH	8WWN-MCH1-MCH-Gi1/β1/γ2
27.59	Single	8Y52	BA1	8Y52-BB₃-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
27.59	Consensus	etb_on	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
27.27	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
27.27	Single	5CGD	HTL14242	5CGD-mGlu₅-HTL14242
27.27	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
27.27	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
27.27	Single	7EZC	UKA	7EZC-A_2A-UKA
27.27	Single	7UM4	AS2674723	7UM4-5-HT_5A-AS2674723
27.27	Single	7Y65	C5a peptide	7Y65-C5a₁-C5a peptide-Gi1/β1/γ2
27.27	Single	8ID8	TUG-891	8ID8-FFA4-TUG-891-Gi1/β1/γ2
27.27	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
27.27	Single	8K2X	CXCL10	8K2X-CXCR3-CXCL10-Gi1/β1/γ2
27.27	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27	Single	8WRZ	PubChem 102336704	8WRZ-CB₁-PubChem 102336704-Arrestin2
27.27	Single	8XJK	Cloprosetnol	8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27	Consensus	c3a_on_gp	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
27.27	Consensus	nucleotide_on_gp	Orthosteric Ligand	adenosine_on_gp p2y_on_gp
26.92	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
26.92	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
26.92	Single	7DW9	AVP	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
26.92	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
26.92	Single	7KH0	AVP	7KH0-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
26.92	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
26.92	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92	Single	8X8L	Cortistatin	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.92	Consensus	fpr2-alx_on_gp	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
26.92	Consensus	gi_formylpeptide	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
26.92	Consensus	gs_vasop-oxy	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
26.92	Consensus	mc5_on_gp	Orthosteric Ligand	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
26.92	Consensus	protein_on	Orthosteric Ligand	chemokine_on chemerin_on
26.92	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
26.92	Consensus	v2_on_gp	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
26.92	Consensus	vasop-oxy_on	Orthosteric Ligand	v2_on
26.92	Consensus	vasop-oxy_on_gp	Orthosteric Ligand	v2_on_gp
26.67	Single	2HPY	All-trans-Retinal	2HPY-Rhodopsin-All-trans-Retinal
26.67	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
26.67	Single	6OY9	All-trans-Retinal	6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
26.67	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
26.67	Single	7MTB	All-trans-Retinal	7MTB-Rhodopsin-All-trans-Retinal-GRK1
26.67	Single	8XOF	Lys05	8XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67	Single	8Y02	Retinal	8Y02-OPN1SW-Retinal-Gi1/β1/γ2
26.67	Single	8ZJE	TAK-448	8ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
26.67	Single	9EE9	Adenosine	9EE9-A_2A-Adenosine-Gs/β1/γ2
26.32	Single	2Y02	Carmoterol	2Y02-β₁-Carmoterol
26.32	Single	5NDD	AZ8838; Na	5NDD-PAR2-AZ8838; Na
26.32	Single	5ZKP	Foropafant (SR27417)	5ZKP-PAF-Foropafant (SR27417)
26.32	Single	6FFH	Fenobam	6FFH-mGlu₅-Fenobam
26.32	Single	6KPF	PubChem 145915889	6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2
26.32	Single	7CFM	P395	7CFM-GPBA-P395-Gs/β1/γ2
26.32	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/β1/γ2
26.32	Single	7NA8	PubChem 178024	7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
26.32	Single	7VGZ	Remalteon	7VGZ-MT₁-Remalteon-Gi1/β1/γ2
26.32	Single	7WC8	Lumateperone	7WC8-5-HT_2A-Lumateperone
26.32	Single	7YK7	DC591053	7YK7-RXFP4-DC591053-Gi2/β1/γ2
26.32	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
26.32	Single	8CIC	Etrumadenant	8CIC-A_2A-Etrumadenant-Na
26.32	Single	8CU6	LJ-4517	8CU6-A_2A-LJ-4517
26.32	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
26.32	Single	8JHN	MMF	8JHN-HCA₂-MMF-Go/β1/γ2
26.32	Single	8KFY	ZK-756326	8KFY-CCR8-ZK-756326-Gi1/β1/γ2
26.32	Single	8UWL	Lisuride	8UWL-5-HT_2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
26.32	Single	8X17	Namodenoson	8X17-A_3A-Namodenoson-Gi1/β1/γ2
26.32	Single	8YH5	Riboprine	8YH5-A_3A-Riboprine-Gi1/β1/γ2
26.32	Single	8ZBE	Octreotide	8ZBE-SST5-Octreotide-Gi1/β1/γ1
26.32	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
26.32	Single	9H37	A1IR0	9H37-A_2A-A1IR0-Na
26.32	Single	9IZC	MK1903	9IZC-HCA₂-MK1903-Gi1/β1/γ2
26.32	Single	9JGK	Balovaptan	9JGK-5-HT_2B-Balovaptan
26.32	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
26.32	Consensus	5ht6_on_gp	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
26.32	Consensus	a3_on	Orthosteric Ligand	a3a_on
26.32	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
26.09	Single	6C1Q	PMX53	6C1Q-C5a₁-PMX53-NDT9513727
26.09	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/β1/γ2
26.09	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/β1/γ2
26.09	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
26.09	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
26.09	Single	7T11	Octreotide	7T11-SST2-Octreotide-Gi3/β1/γ2
26.09	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/β1/γ2
26.09	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09	Single	8XZF	WN561	8XZF-Apelin-WN561-Gi1/β1/γ2
26.09	Consensus	cxcr_on_gp	Orthosteric Ligand	cxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
26.09	Consensus	formylpeptide_on	Orthosteric Ligand	fpr2-alx_on fpr1-alx_on
25.93	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-α-factor mating pheromone
25.93	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
25.93	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.93	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/β1/γ2
25.93	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/β1/γ2
25.93	Single	8WWK	MCH	8WWK-MCH1-MCH-Gi1/β1/γ2
25.93	Single	8ZPS	PrRP20	8ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93	Single	9JFY	hNPSF	9JFY-NPFF2-hNPSF-Gi1/β1/γ2
25.93	Consensus	cml1_on_gp	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
25.81	Consensus	melanocortin_on	Orthosteric Ligand	mc1_on mc4_on mc2_on mc3_on mc5_on
25.81	Consensus	melanocortin_on_gp	Orthosteric Ligand	mc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
25.00	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
25.00	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
25.00	Single	5N2S	PSB36	5N2S-A₁-PSB36
25.00	Single	5T1A	BMS-681	5T1A-CCR2-BMS-681-PubChem 12093170
25.00	Single	5WKT	Octyl-Beta-D-Glucopyranoside	5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
25.00	Single	6KPC	PubChem 145915889	6KPC-CB₂-PubChem 145915889
25.00	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
25.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
25.00	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
25.00	Single	7MT9	All-trans-Retinal	7MT9-Rhodopsin-All-trans-Retinal-GRK1
25.00	Single	7MTA	All-trans-Retinal	7MTA-Rhodopsin-All-trans-Retinal-GRK1
25.00	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-α-factor mating pheromone
25.00	Single	7VFX	fMLF	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
25.00	Single	7W41	PD176252	7W41-BB₂-PD176252
25.00	Single	7W56	Neuromedin-S	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2
25.00	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/β1/γ2
25.00	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/β1/γ2
25.00	Single	8DPI	Lorcaserin	8DPI-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00	Single	8G59	TUG-891	8G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
25.00	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00	Single	8ID4	Linoleic acid	8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
25.00	Single	8IU2	Retinal	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00	Single	8K3Z	CXCL12	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
25.00	Single	8KFX	LMD-009	8KFX-CCR8-LMD-009-Gi1/β1/γ2
25.00	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Gi1/β1/γ2
25.00	Single	8WKY	PG-934	8WKY-MC₄-PG-934
25.00	Single	8X0B	VU0424465	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
25.00	Single	8X0C	VU0424465	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
25.00	Single	8ZJD	Kisspeptin-10	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
25.00	Single	8ZPT	PrRP20	8ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00	Single	9ARY	Serotonin	9ARY-5-HT_2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00	Single	9BLW	Cagrilintide backbone (non-acylated)	9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
25.00	Single	9EHS	LUF7602	9EHS-A_3A-LUF7602
25.00	Single	9ERX	D9-THC analog	9ERX-CB₁-D9-THC analog-Gi1/β1/γ2
25.00	Single	9HB3	Mambaquaretin-1	9HB3-V₂-Mambaquaretin-1
25.00	Single	9IYB	Prostaglandin	9IYB-DP₂-Prostaglandin-A1D5Q-Gi1/β1/γ2
25.00	Single	9KPF	SA0	9KPF-TAS2R16-SA0-Gi1/β1/γ2
25.00	Consensus	a3_on_gp	Orthosteric Ligand	a3a_on_gp
25.00	Consensus	a3a_on	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
25.00	Consensus	a3a_on_gp	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
25.00	Consensus	bb2_off	Orthosteric Ligand	7W41-BB₂-PD176252
25.00	Consensus	bombesin_off	Orthosteric Ligand	bb2_off
25.00	Consensus	chemerin_on_gp	Orthosteric Ligand	cml1_on_gp
25.00	Consensus	cml1_on	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
25.00	Consensus	crf_on_gp	Orthosteric Ligand	crf2_on_gp crf1_on_gp
25.00	Consensus	cxcr4_on	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
25.00	Consensus	fpr1-alx_on	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
25.00	Consensus	fpr1-alx_on_gp	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
25.00	Consensus	gi_chemerin	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
25.00	Consensus	gi_compl-pept	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
25.00	Consensus	gi_nucleotide	Orthosteric Ligand	gi_adenosine gi_p2y
25.00	Consensus	gi_opsins	Orthosteric Ligand	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
25.00	Consensus	gi_sensory	Orthosteric Ligand	gi_opsins
25.00	Consensus	gq_kisspeptin	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
25.00	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_melanocortin gs_vasop-oxy
25.00	Consensus	kiss1_on_gp	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
25.00	Consensus	kisspeptin_on_gp	Orthosteric Ligand	kiss1_on_gp
25.00	Consensus	lpa1_on	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
25.00	Consensus	lpa1_on_gp	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
25.00	Consensus	opsin1lw_on	Orthosteric Ligand	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00	Consensus	opsin1lw_on_gp	Orthosteric Ligand	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00	Consensus	protein_on_gp	Orthosteric Ligand	chemokine_on_gp chemerin_on_gp
25.00	Consensus	s1p5_off	Orthosteric Ligand	7YXA-S1P₅-ONO-5430608
24.24	Consensus	class-a_class-b1_cons_on_gp	Orthosteric Ligand	class-a_on_gp class-b1_on_gp
24.14	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
24.14	Single	7F53	Alpha-MSH	7F53-MC₄-α-MSH-Gs/β1/γ2
24.14	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-α-factor mating pheromone
24.14	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/β1/γ2
24.14	Single	8W8W	Alpha-MSH	8W8W-MC₃-α-MSH-Ca-Gs/β1/γ2
24.14	Single	8WWL	MCH	8WWL-MCH1-MCH-Gi1/β1/γ2
24.14	Single	9BUC	Cagrilintide	9BUC-CT-Cagrilintide-Gs/β1/γ2
24.00	Single	8F7Q	Beta-Endorphin	8F7Q-μ-β-Endorphin-Gi1/β1/γ2
24.00	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/β1/γ2
24.00	Consensus	ccr8_on_gp	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
24.00	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
24.00	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
23.81	Single	4IAQ	Dihydroergotamine	4IAQ-5-HT_1B-Dihydroergotamine
23.81	Single	4OO9	Mavoglurant	4OO9-mGlu₅-Mavoglurant
23.81	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/β1/γ2
23.81	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/β1/γ2
23.81	Single	7P2L	4YI	7P2L-mGlu₅-4YI
23.81	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
23.81	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/β1/γ2
23.81	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/β1/γ2
23.81	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/β1/γ2
23.81	Single	8GUS	HU-308	8GUS-CB₂-HU-308-Gi1/β1/γ2
23.81	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/β1/γ2
23.81	Single	8I9L	C3a anaphylatoxin	8I9L-C3a_B-C3a anaphylatoxin-Go/β1/γ2
23.81	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
23.81	Single	8ID6	Oleic acid	8ID6-FFA4-Oleic acid-Gi1/β1/γ2
23.81	Single	8IUK	PGF2-alpha	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81	Single	8JZP	C5A anaphylatoxin	8JZP-C5a₁-C5A anaphylatoxin-Go/β1/γ2
23.81	Single	8TAO	CDPPB	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
23.81	Single	8X0B	VU0424465	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
23.81	Single	8X0F	VU0424465	8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
23.81	Single	8X16	Piclidenoson	8X16-A_3A-Piclidenoson-Gi1/β1/γ2
23.81	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/β1/γ2
23.81	Single	8ZR5	Firuglipel	8ZR5-GPR119-Firuglipel-Gs/β1/γ2
23.81	Single	9UY3	Anamorelin	9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81	Consensus	gi_lpa	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
23.81	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
23.81	Consensus	lpa_on_gp	Orthosteric Ligand	lpa1_on_gp
23.81	Consensus	motilin_on	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81	Consensus	protein_off	Orthosteric Ligand	chemokine_off grh_off
23.53	Single	6HLL	CP99994	6HLL-NK₁-CP99994
23.53	Single	6QNO	All-trans-Retinal	6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
23.53	Single	6TP4	ACT-462206	6TP4-OX₁-ACT-462206
23.53	Single	6TQ4	PubChem 16046844	6TQ4-OX₁-PubChem 16046844-Na
23.53	Single	7D76	Beclomethasone	7D76-ADGRG3-Beclomethasone-Go/β1/γ2
23.53	Single	7XP6	Strychnine	7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
23.53	Single	7XT9	Serotonin	7XT9-5-HT₄-Serotonin-Gs/β1/γ2
23.53	Single	7YS6	Serotonin	7YS6-5-HT₆-Serotonin-chim(NtGi1-Gs)/β1/γ2
23.53	Single	8JIL	Niacin	8JIL-HCA₂-Niacin-Gi1/β1/γ2
23.53	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53	Single	8X2K	Oleic monoethanolamide	8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
23.53	Single	8YH3	N-methyladenosine	8YH3-A_3A-N-methyladenosine-Gi1/β1/γ2
23.53	Single	8YN2	Histamine	8YN2-H₁-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.53	Single	9AS7	Psilocin	9AS7-5-HT_2A-Psilocin
23.53	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
23.33	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-α-factor mating pheromone
23.33	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
23.33	Consensus	bk2_on	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
23.33	Consensus	bk2_on_gp	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
23.33	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on
23.33	Consensus	bradykinin_on_gp	Orthosteric Ligand	bk2_on_gp
23.33	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
23.33	Consensus	gs_melanocortin	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2 8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2
23.08	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
23.08	Single	6W25	SHU9119	6W25-MC₄-SHU9119-Ca
23.08	Single	7F4D	Alpha-MSH	7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2
23.08	Single	7O7F	6P4-CCL5	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
23.08	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08	Single	8W8Y	Gamma-MSH	8W8Y-MC₃-γ-MSH-Ca-Gs/β1/γ2
23.08	Single	8WKZ	SBL-MC-31	8WKZ-MC₄-SBL-MC-31
23.08	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/β1/γ2
23.08	Single	9K27	PrRP31	9K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
23.08	Single	9U4W	Gonadoliberin-1	9U4W-GnRH₁-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.08	Consensus	compl-peptide_on_gp	Orthosteric Ligand	c5a1_on_gp c3a_on_gp
23.08	Consensus	cxcr4_on_gp	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
22.86	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
22.86	Consensus	mc2_on_gp	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
22.73	Single	6C1R	PMX53	6C1R-C5a₁-PMX53-Avacopan; Na
22.73	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
22.73	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/β1/γ2
22.73	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73	Single	8HK2	C3a anaphylatoxin	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2
22.73	Single	8IBU	Erythromycin-A	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73	Single	8IQ6	Latanoprost	8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73	Single	8JJP	Chemerin	8JJP-CML2-Chemerin-Gi1/β1/γ2
22.73	Single	8X8N	Octreotide	8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.73	Single	8XJN	Cloprosetnol	8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73	Single	9GGG	I-BOP	9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73	Consensus	ccr8_on	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
22.73	Consensus	motilin_on_gp	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2
22.58	Consensus	ccr5_on_gp	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
22.58	Consensus	class-a_class-b1_cons_on	Orthosteric Ligand	class-a_on class-b1_on
22.22	Single	2X72	All-trans-Retinal	2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
22.22	Single	5OLV	LUAA41063	5OLV-A_2A-LUAA41063-Na
22.22	Single	6DS0	Ly266097	6DS0-5-HT_2B-Ly266097
22.22	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
22.22	Single	6NWE	Octyl-Beta-D-Glucopyranoside	6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
22.22	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
22.22	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
22.22	Single	7T10	Somatostatin-14	7T10-SST2-Somatostatin-14-Gi3/β1/γ2
22.22	Single	7TUZ	7-alpha,25-dihydroxycholesterol	7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
22.22	Single	7W0M	PubChem 122701908	7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
22.22	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/β1/γ2
22.22	Single	8DWG	ML382	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/β1/γ2
22.22	Single	8WST	Pro-MCH	8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.22	Single	8XXV	Indomethacin	8XXV-DP₂-Indomethacin-A1D5Q-Gi1/β1/γ2
22.22	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
22.22	Single	9H2X	A1IR1	9H2X-A_2A-A1IR1-Na
22.22	Consensus	apelin_on	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
22.22	Consensus	apelin_on_gp	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
22.22	Consensus	c5a1_on_gp	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
21.74	Single	4NC3	Ergotamine	4NC3-5-HT_2B-Ergotamine
21.74	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
21.74	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/β1/γ2
21.74	Single	8XJO	U46619	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74	Consensus	chemerin_on	Orthosteric Ligand	cml1_on
21.74	Consensus	fp-alpha_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74	Consensus	fp-alpha_on_gp	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74	Consensus	prostanoid_on	Orthosteric Ligand	tp_on fp-alpha_on
21.74	Consensus	prostanoid_on_gp	Orthosteric Ligand	tp_on_gp fp-alpha_on_gp
21.74	Consensus	tp_on	Orthosteric Ligand	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74	Consensus	tp_on_gp	Orthosteric Ligand	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/β1/γ2
21.43	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
21.43	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/β1/γ2
21.43	Single	8GEJ	Constrained Epinephrine	8GEJ-β₂-Constrained Epinephrine-Gs/β1/γ2
21.43	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43	Single	8WCC	Cyclohexylammonium Ion	8WCC-TA1-Cyclohexylammonium Ion
21.43	Single	8WWM	MCH	8WWM-MCH1-MCH-Gi1/β1/γ2
21.43	Single	8XVH	Endothelin-1	8XVH-ET_B-Endothelin-1-chim(Gs-CtGq)/β1/γ2
21.43	Consensus	chemokine_off	Orthosteric Ligand	ccr_off cxcr_off
21.43	Consensus	chemokine_on_gp	Orthosteric Ligand	ccr_on_gp cxcr_on_gp
21.43	Consensus	cxcr_off	Orthosteric Ligand	cxcr3_off cxcr4_off
21.43	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43	Consensus	eta_on_gp	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43	Consensus	gi_apelin	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.43	Consensus	gi_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
21.43	Consensus	vpac1_on	Orthosteric Ligand	8E3Z-VPAC₁-VIP-Gs/β1/γ2
21.05	Single	5TE3	Octyl-Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
21.05	Single	6ME4	2-Iodomelatonin	6ME4-MT₁-2-Iodomelatonin
21.05	Single	6ZDV	Chromone 5d	6ZDV-A_2A-Chromone 5d-Na
21.05	Single	7T32	ZM-241385	7T32-A_2A-ZM-241385
21.05	Single	7VOD	Cariprazine	7VOD-5-HT_2A-Cariprazine
21.05	Single	7XOV	SR146131	7XOV-CCK_A-SR146131-Gs/β1/γ2
21.05	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05	Single	8K2W	AMG487	8K2W-CXCR3-AMG487
21.05	Single	8Y62	C16:0 Ceramide	8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
21.05	Single	8ZPN	AMD3100	8ZPN-CXCR4-AMD3100
21.05	Single	9M2F	Neuropeptide FF	9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
21.05	Consensus	cb1_off	Orthosteric Ligand	5U09-CB₁-Taranabant 5TGZ-CB₁-AM6538
21.05	Consensus	cxcr3_off	Orthosteric Ligand	8K2W-CXCR3-AMG487
21.05	Consensus	pth_on_gp	Orthosteric Ligand	pth1_on_gp pth2_on_gp
20.83	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.83	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
20.83	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/β1/γ2
20.83	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
20.83	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
20.83	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
20.83	Consensus	kiss1_on	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.83	Consensus	kisspeptin_on	Orthosteric Ligand	kiss1_on
20.69	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
20.69	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
20.69	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
20.69	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
20.69	Single	8XQF	Apelin-13	8XQF-Apelin-Apelin-13-Gi1/β1/γ2
20.69	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
20.69	Consensus	npy4_on_gp	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
20.69	Consensus	vpac1_on_gp	Orthosteric Ligand	8E3Z-VPAC₁-VIP-Gs/β1/γ2
20.59	Single	7X9A	Neuropeptide-Y	7X9A-Y₁-Neuropeptide-Y-Gi1/β1/γ2
20.59	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/β1/γ2
20.59	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/β1/γ2
20.59	Single	9JR3	PTH	9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00	Single	5UIG	Cmpd-1	5UIG-A_2A-Cmpd-1
20.00	Single	6D27	CAY10471	6D27-DP₂-CAY10471
20.00	Single	6IIV	Daltroban	6IIV-TXA2-Daltroban
20.00	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/β1/γ2
20.00	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
20.00	Single	6XBM	5LWE	6XBM-SMO-5LWE-Gi1/β1/γ2
20.00	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/β1/γ2
20.00	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
20.00	Single	7VH0	Ramelteon	7VH0-MT₂-Ramelteon-Gi1/β1/γ1
20.00	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00	Single	7WC4	Serotonin	7WC4-5-HT_2A-Serotonin
20.00	Single	7YOO	Neuropeptide-Y	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
20.00	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
20.00	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
20.00	Single	8IZB	Lysophosphatidylserine	8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
20.00	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
20.00	Single	8KEX	DCA-3P	8KEX-MRGPRX4-DCA-3P
20.00	Single	8KIG	SHU9119	8KIG-MC₃-SHU9119-Ca
20.00	Single	8X9T	AP503	8X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
20.00	Single	8XGM	Chemerin	8XGM-CML2-Chemerin-Gi1/β1/γ2
20.00	Single	8ZCJ	Pasireotide	8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
20.00	Single	8ZJG	Chemerin	8ZJG-CML1-Chemerin-Gi1/β1/γ2
20.00	Single	9BKJ	Cholecystokinin-8	9BKJ-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00	Single	9IV2	5alpha-DHT	9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
20.00	Single	9L3Y	Retinoic acid receptor responder protein 2	9L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
20.00	Consensus	cck_off	Orthosteric Ligand	ccka_off
20.00	Consensus	ccka_off	Orthosteric Ligand	7F8Y-CCK_A-Devazepide 7F8U-CCK_A-Lintitript
20.00	Consensus	mc4_on	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
20.00	Consensus	nmur1_on_gp	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
20.00	Consensus	npy2_on_gp	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
20.00	Consensus	p2y10_on_gp	Orthosteric Ligand	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
20.00	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
19.51	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
19.35	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/β1/γ2
19.35	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
19.35	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/β1/γ2
19.35	Single	7VGX	Neuropeptide-Y	7VGX-Y₁-Neuropeptide-Y-Gi1/β1/γ2
19.35	Single	8F0K	Pramlintide Analogue San385	8F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
19.35	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2
19.35	Single	8KGG	LPS	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
19.35	Consensus	pth1_on	Orthosteric Ligand	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
19.23	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
19.23	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
19.23	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/β1/γ2
19.23	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/β1/γ2
19.23	Single	8XYD	Platelet Activating Factor	8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
19.23	Single	8Z7J	Agonistic antibody	8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
19.23	Single	9IQS	Muscarinic toxin 3	9IQS-M₄-Muscarinic toxin 3
19.23	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
19.23	Consensus	mc4_on_gp	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
19.05	Single	4WW3	All-trans-Retinal	4WW3-Rhodopsin-All-trans-Retinal
19.05	Single	5N2R	PSB-36	5N2R-A_2A-PSB-36-Na
19.05	Single	5NM2	ZM-241385	5NM2-A_2A-ZM-241385-Na
19.05	Single	5YHL	PubChem 135121352	5YHL-EP₄-PubChem 135121352
19.05	Single	5YWY	ONO-AE3-208	5YWY-EP₄-ONO-AE3-208
19.05	Single	7BB7	AVP	7BB7-V₂-AVP-Gs/β1/γ2
19.05	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
19.05	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/β1/γ2
19.05	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/β1/γ2
19.05	Single	8GNE	KW-6356	8GNE-A_2A-KW-6356-Na
19.05	Single	8WGB	VU0155041	8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
19.05	Single	8ZVZ	BW245C	8ZVZ-DP₁-BW245C-Gs/β1/γ2
19.05	Single	9B9Z	A1AKO	9B9Z-CB₁-A1AKO
19.05	Single	9GE2	ML184	9GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
19.05	Single	9HC0	4YI	9HC0-mGlu₅-4YI
19.05	Consensus	a1_off	Orthosteric Ligand	5UEN-A₁-DU172 5N2S-A₁-PSB36
19.05	Consensus	adenosine_off	Orthosteric Ligand	a1_off a2_off
19.05	Consensus	ep4_off	Orthosteric Ligand	5YWY-EP₄-ONO-AE3-208 5YHL-EP₄-PubChem 135121352
19.05	Consensus	ep_off	Orthosteric Ligand	ep4_off
19.05	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on p2y_on
18.92	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/β1/γ2
18.92	Consensus	pth2_on_gp	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2
18.75	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/β1/γ2
18.75	Single	9C2F	Ca; Ca; Tryptophan; '54149; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
18.75	Consensus	crf1_on	Orthosteric Ligand	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF₁-Corticoliberin-Gs/β1/γ2
18.75	Consensus	gi_npy	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
18.75	Consensus	npy_on	Orthosteric Ligand	npy1_on npy2_on npy4_on
18.75	Consensus	npy_on_gp	Orthosteric Ligand	npy1_on_gp npy2_on_gp npy4_on_gp
18.52	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
18.52	Single	8K6M	Neuropeptide-Y	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
18.52	Single	8XZG	Apelin-13	8XZG-Apelin-Apelin-13-Gi1/β1/γ2
18.52	Single	9M1O	Morphine-Modulating Neuropeptide B	9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
18.52	Consensus	c5a1_on	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
18.52	Consensus	cckb_on_gp	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
18.52	Consensus	ccr_on	Orthosteric Ligand	ccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
18.52	Consensus	npy1_on	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
18.52	Consensus	npy1_on_gp	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
18.18	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/β1/γ1
18.18	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
18.18	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
18.18	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
18.18	Single	7XOW	Gastrin	7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2
18.18	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/β1/γ2
18.18	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/β1/γ2
18.18	Single	8FLU	Long-Acting PTH	8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
18.18	Single	8ZW0	PGD2	8ZW0-DP₁-PGD2-Gs/β1/γ2
18.18	Single	9AST	Lymphotactin	9AST-XCR1-Lymphotactin-Gi1/β1/γ2
18.18	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
18.18	Consensus	cyslt1_off	Orthosteric Ligand	6RZ5-CysLT₁-Zafirlukast-Na 6RZ4-CysLT₁-Pranlukast-Na
18.18	Consensus	npy_off	Orthosteric Ligand	npy1_off npy2_off
17.86	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
17.86	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.86	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/β1/γ2
17.86	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
17.86	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
17.86	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
17.86	Single	7YON	Peptide-YY(3-36)	7YON-Y₂-Peptide-YY(3-36)-Gi1/β1/γ2
17.86	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
17.86	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
17.86	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/β1/γ2
17.86	Single	9EBO	GLP-1 (ACPC18)	9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
17.86	Consensus	p2y_on_gp	Orthosteric Ligand	p2y1_on_gp p2y10_on_gp p2y12_on_gp
17.86	Consensus	protein_offon	Orthosteric Ligand	protein_off protein_on
17.86	Consensus	protein_offon_gp	Orthosteric Ligand	protein_on_gp protein_off
17.65	Single	3UZA	GTPL9236	3UZA-A_2A-GTPL9236
17.65	Single	6ME5	Agomelatine	6ME5-MT₁-Agomelatine
17.65	Single	7D77	Hydrocortisone	7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
17.65	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/β1/γ2
17.65	Single	7WC5	Psilocin	7WC5-5-HT_2A-Psilocin
17.65	Single	8EIT	Doconexent	8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.65	Single	8J21	Butyric acid	8J21-FFA3-Butyric acid-Gi1/β1/γ2
17.65	Single	8J24	Acetic acid	8J24-FFA2-Acetic acid-Gi1/β1/γ2
17.65	Single	8JEF	(3S)-3-hydroxyoctanoic acid	8JEF-HCA₃-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
17.65	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
17.65	Single	8Y63	C20:0 Ceramide	8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
17.65	Single	9IV1	5alpha-DHT	9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
17.65	Consensus	crf1_on_gp	Orthosteric Ligand	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF₁-Corticoliberin-Gs/β1/γ2
17.65	Consensus	ffa3_on	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/β1/γ2
17.65	Consensus	ffa3_on_gp	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/β1/γ2
17.65	Consensus	glp1_on_gp	Orthosteric Ligand	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
17.65	Consensus	pth1_on_gp	Orthosteric Ligand	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
17.39	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
17.39	Single	5TZY	MK8666; AP8	5TZY-FFA1-MK8666; AP8
17.39	Single	6AK3	Dinoprostone IPGE2	6AK3-EP₃-Dinoprostone IPGE2
17.39	Single	6IIU	Ramatroban	6IIU-TXA2-Ramatroban
17.39	Single	7F55	Bremelanotide	7F55-MC₄-Bremelanotide-Gs/β1/γ2
17.39	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/β1/γ2
17.39	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
17.39	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/β1/γ2
17.39	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/β1/γ2
17.39	Single	8XQS	Cholesterol	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
17.39	Single	9AU0	BW245C	9AU0-DP₁-BW245C-Gs/β1/γ2
17.39	Single	9L3W	Retinoic acid receptor responder protein 2	9L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
17.39	Consensus	cxcr_on	Orthosteric Ligand	cxcr3_on cxcr4_on cxcr1_on cxcr2_on
17.24	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/β1/γ2
17.24	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
17.24	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
17.24	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/β1/γ2
17.24	Single	7X9B	Neuropeptide-Y	7X9B-Y₂-Neuropeptide-Y-Gi1/β1/γ2
17.24	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
17.24	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/β1/γ2
17.24	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/β1/γ2
17.24	Single	8XVI	Endothelin-1	8XVI-ET_A-Endothelin-1-chim(Gs-CtGq)/β1/γ2
17.24	Consensus	ccr_on_gp	Orthosteric Ligand	ccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
17.24	Consensus	p2y10_on	Orthosteric Ligand	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
17.14	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2
16.67	Single	3AYM	All-trans-Retinal	3AYM-Rhodopsin-All-trans-Retinal
16.67	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
16.67	Single	6FJ3	PTH	6FJ3-PTH1-PTH
16.67	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/β1/γ2
16.67	Single	6PH7	Nerol	6PH7-Rhodopsin-Nerol-Gt(CT)
16.67	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/β1/γ1
16.67	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/β1/γ2
16.67	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/β1/γ2
16.67	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67	Single	7PIU	Setmelanotide	7PIU-MC₄-Setmelanotide-Gs/β1/γ2
16.67	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
16.67	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
16.67	Single	7T96	LY2119620	7T96-M₂-Acetylcholine-LY2119620-Go/β1/γ2
16.67	Single	7TRP	LY2033298	7TRP-M₄-Iperoxo-LY2033298-Gi1/β1/γ2
16.67	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
16.67	Single	7VUI	JNJ-63533054	7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
16.67	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/β1/γ2
16.67	Single	8A2P	LUAA47070	8A2P-A_2A-LUAA47070-Na
16.67	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/β1/γ2
16.67	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
16.67	Single	8ZPL	HF51116	8ZPL-CXCR4-HF51116
16.67	Single	8ZX5	AM251	8ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
16.67	Single	9B9Y	7DY	9B9Y-CB₁-7DY
16.67	Single	9BLB	Cagrilintide backbone (non-acylated)	9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
16.67	Single	9BP3	Cagrilintide	9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
16.67	Single	9GG5	U46619	9GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67	Single	9L3Z	LRH7-C2	9L3Z-CML1-LRH7-C2
16.67	Single	9LMP	NE52-QQ57	9LMP-GPR4-NE52-QQ57
16.67	Single	9M1H	Prostaglandin E2	9M1H-EP₁-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
16.67	Consensus	cck_on_gp	Orthosteric Ligand	ccka_on_gp cckb_on_gp
16.67	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
16.67	Consensus	ccr_off	Orthosteric Ligand	ccr2_off ccr5_off
16.67	Consensus	pac1_on	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
16.67	Consensus	pac1_on_gp	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
16.67	Consensus	pac_on_gp	Orthosteric Ligand	pac1_on_gp
16.67	Consensus	secretin_on	Orthosteric Ligand	7D3S-Secretin-Secretin-Gs/β1/γ2
16.13	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
16.13	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
16.13	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/β1/γ2
16.13	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/β1/γ2
16.13	Single	8W8X	Beta-MSH	8W8X-MC₃-β-MSH-Ca-Gs/β1/γ2
16.13	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
16.13	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
16.13	Consensus	glp_on_gp	Orthosteric Ligand	glp1_on_gp glp2_on_gp
16.13	Consensus	secretin_on_gp	Orthosteric Ligand	7D3S-Secretin-Secretin-Gs/β1/γ2
16.00	Single	5VBL	Apelin mimetic peptide agonist	5VBL-Apelin-Apelin mimetic peptide agonist
16.00	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
16.00	Single	7F9Z	GHRP-6	7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/β1/γ2
16.00	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/β1/γ2
16.00	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00	Single	8XQL	Cholesterol	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
16.00	Single	9JF4	PD168368	9JF4-BB₁-PD168368
16.00	Single	9NS9	TUG-1375	9NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
16.00	Consensus	nmur1_on	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79	Single	2Z73	11-cis-Retinal	2Z73-Rhodopsin-11-cis-Retinal
15.79	Single	3AYN	9-cis-Retinal	3AYN-Rhodopsin-9-cis-Retinal
15.79	Single	3VGA	ZM-241385	3VGA-A_2A-ZM-241385-Antibody
15.79	Single	4MQT	LY2119620	4MQT-M₂-Iperoxo-LY2119620
15.79	Single	5U09	Taranabant	5U09-CB₁-Taranabant
15.79	Single	5ZKQ	ABT-491	5ZKQ-PAF-ABT-491
15.79	Single	6ME9	Ramelteon	6ME9-MT₂-Ramelteon
15.79	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
15.79	Single	7F8U	Lintitript	7F8U-CCK_A-Lintitript
15.79	Single	7F8Y	Devazepide	7F8Y-CCK_A-Devazepide
15.79	Single	7S8P	MS47134	7S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79	Single	7W0O	Elabela	7W0O-Apelin-Elabela-Gi1/β1/γ2
15.79	Single	7XJJ	Galanin	7XJJ-GAL₁-Galanin-Go/β1/γ2
15.79	Single	8DU3	PubChem 105526064	8DU3-A_2A-PubChem 105526064
15.79	Single	8GNG	Istradefylline	8GNG-A_2A-Istradefylline
15.79	Single	8J20	Valeric acid	8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
15.79	Single	8RW0	Istradefylline	8RW0-A_2A-Istradefylline-Na
15.79	Single	8T3S	Butyric acid	8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79	Single	8U4P	AMD3100	8U4P-CXCR4-AMD3100-Gi1/β1/γ2
15.79	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
15.79	Consensus	paf_off	Orthosteric Ligand	5ZKQ-PAF-ABT-491
15.62	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/β1/γ2
15.62	Single	6NBH	Long-Acting PTH Analog	6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
15.62	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/β1/γ2
15.62	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/β1/γ2
15.62	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
15.62	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
15.62	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/β1/γ2
15.62	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
15.62	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
15.62	Single	9BYO	Exendin-3	9BYO-GLP-1-Exendin-3-Gs/β1/γ2
15.62	Consensus	vip-pacap_on	Orthosteric Ligand	vpac_on pac_on
15.62	Consensus	vip-pacap_on_gp	Orthosteric Ligand	vpac_on_gp pac_on_gp
15.38	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/β1/γ2
15.38	Single	8F0J	Pramlintide Analogue San45	8F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
15.38	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
15.38	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
15.38	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
15.38	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
15.38	Single	8INR	Alpha-MSH	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.38	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
15.38	Single	9J0I	UDP-Glucuronic acid	9J0I-P2Y₁₄-UDP-Glucuronic acid-Gi1/β1/γ2
15.38	Consensus	chemokine_on	Orthosteric Ligand	ccr_on cxcr_on
15.38	Consensus	p2y_on	Orthosteric Ligand	p2y1_on p2y10_on p2y12_on
15.15	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
15.15	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
15.00	Single	5IU7	Q27456346	5IU7-A_2A-Q27456346-Na
15.00	Single	5JTB	ZM-241385	5JTB-A_2A-ZM-241385
15.00	Single	5K2B	ZM-241385	5K2B-A_2A-ZM-241385-Na
15.00	Single	6AQF	ZM-241385	6AQF-A_2A-ZM-241385
15.00	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
15.00	Single	6MH8	ZM-241385	6MH8-A_2A-ZM-241385
15.00	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
15.00	Single	6WJC	Muscarinic toxin 7	6WJC-M₁-Atropine-Muscarinic toxin 7
15.00	Single	6ZDR	HMS1413f12	6ZDR-A_2A-HMS1413f12-Na
15.00	Single	7ARO	LUF5833	7ARO-A_2A-LUF5833-Na
15.00	Single	7BB6	AVP	7BB6-V₂-AVP-Gs/β1/γ2
15.00	Single	7T94	LY2119620	7T94-M₂-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
15.00	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.00	Single	8F2B	Pramlintide Analogue San45	8F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
15.00	Single	8HQN	9-S-HODE	8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
15.00	Single	8K4S	DCA-3P	8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00	Single	8RQQ	ZM-241385	8RQQ-A_2A-ZM-241385-Na
15.00	Single	8RWC	StilSwitch2	8RWC-A_2A-StilSwitch2-Na
15.00	Single	8RWD	StilSwitch3	8RWD-A_2A-StilSwitch3-Na
15.00	Single	8RWI	StilSwitch2	8RWI-A_2A-StilSwitch2-Na
15.00	Single	9BA0	A1AKN	9BA0-CB₁-A1AKN
15.00	Single	9JFU	NE52-QQ57	9JFU-GPR4-NE52-QQ57
15.00	Single	9K1D	Butanoic acid	9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
15.00	Consensus	a2_off	Orthosteric Ligand	a2a_off
15.00	Consensus	a2a_off	Orthosteric Ligand	3RFM-A_2A-Caffeine 8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-2-118 8PWN-A_2A-Theophylline 5IU4-A_2A-ZM-241385-Na 5OLZ-A_2A-PubChem 135566609-Na 6GT3-A_2A-Imaradenant-Na 5OLV-A_2A-LUAA41063-Na 5N2R-A_2A-PSB-36-Na 5IU7-A_2A-Q27456346-Na 5OLH-A_2A-Vipadenant-Na 5OLO-A_2A-Tozadenant-Na 6ZDR-A_2A-HMS1413f12-Na 8GNE-A_2A-KW-6356-Na 8JWZ-A_2A-AB928-Na 5IU8-A_2A-Q27456347-Na 5IUB-A_2A-Q27456344-Na 6ZDV-A_2A-Chromone 5d-Na 5IUA-A_2A-Q27456348-Na 8A2P-A_2A-LUAA47070-Na
15.00	Consensus	grh_off	Orthosteric Ligand	gnrh1_off
15.00	Consensus	p2y1_on_gp	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
14.81	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
14.81	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
14.81	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/β1/γ2
14.81	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
14.81	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
14.81	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
14.81	Single	8WSS	Pro-MCH	8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
14.81	Single	9EAI	Nanobody AT209	9EAI-AT₁-Losartan-Nanobody AT209
14.81	Single	9IQR	Muscarinic toxin 3	9IQR-α_2a-Muscarinic toxin 3
14.81	Single	9J0F	NADH	9J0F-P2Y₁₄-NADH-Gi1/β1/γ2
14.81	Consensus	cckb_on	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
14.71	Single	8F2A	Pramlintide Analogue San385	8F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
14.71	Consensus	glp1_on	Orthosteric Ligand	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
14.29	Single	3EML	ZM-241385	3EML-A_2A-ZM-241385
14.29	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
14.29	Single	4EIY	ZM-241385	4EIY-A_2A-ZM-241385-Na
14.29	Single	5IU8	Q27456347	5IU8-A_2A-Q27456347-Na
14.29	Single	5K2A	ZM-241385	5K2A-A_2A-ZM-241385-Na
14.29	Single	5OLG	ZM-241385	5OLG-A_2A-ZM-241385-Na
14.29	Single	5UEN	DU172	5UEN-A₁-DU172
14.29	Single	5VRA	ZM-241385	5VRA-A_2A-ZM-241385-Na
14.29	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
14.29	Single	6ORV	TT-OAD2	6ORV-GLP-1-TT-OAD2-Gs/β1/γ2
14.29	Single	6S0L	ZM-241385	6S0L-A_2A-ZM-241385
14.29	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
14.29	Single	6VN7	PACAP	6VN7-VPAC₁-PACAP-Gs/β1/γ2
14.29	Single	7PP1	Selatogrel	7PP1-P2Y₁₂-Selatogrel
14.29	Single	7PYR	PSB-2115	7PYR-A_2A-PSB-2115
14.29	Single	7TRQ	VU0467154	7TRQ-M₄-Iperoxo-VU0467154-Gi1/β1/γ2
14.29	Single	7WQ3	Galanin	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
14.29	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/β1/γ2
14.29	Single	8EJK	TAK-875	8EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29	Single	8GCM	L902688	8GCM-EP₄-L902688-Gi1/β1/γ2
14.29	Single	8K6N	Pro-neuropeptide-Y	8K6N-Y₂-Pro-neuropeptide-Y-Gi2/β1/γ1
14.29	Single	8RW7	StilSwitch1	8RW7-A_2A-StilSwitch1-Na
14.29	Single	8RWX	StilSwitch3	8RWX-A_2A-StilSwitch3-Na
14.29	Single	8XJL	PGF2-alpha	8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
14.29	Single	9B5Y	Long-Acting PTH	9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
14.29	Single	9IYA	ONO-9710531	9IYA-GPR55-ONO-9710531
14.29	Single	9JR2	PTH	9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
14.29	Consensus	ccr2_on_gp	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
14.29	Consensus	class-b1_on_gp	Orthosteric Ligand	glucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
14.29	Consensus	gal1_on	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
14.29	Consensus	gal1_on_gp	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
14.29	Consensus	gi_galanin	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
14.29	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
14.29	Consensus	mc3_on_gp	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
14.29	Consensus	nucleotide_offon	Orthosteric Ligand	nucleotide_off nucleotide_on
14.29	Consensus	nucleotide_offon_gp	Orthosteric Ligand	nucleotide_on_gp nucleotide_off
13.89	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
13.89	Consensus	glucagon_on	Orthosteric Ligand	glp_on gluc_on secretin_on gip_on
13.79	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/β1/γ2
13.79	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/β1/γ2
13.79	Single	8YW3	Retatrutide	8YW3-GLP-1-Retatrutide-Gs/β1/γ2
13.79	Single	8YW4	Retatrutide	8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
13.79	Single	8YW5	Retatrutide	8YW5-Glucagon-Retatrutide-Gs/β1/γ2
13.79	Single	9BLC	Cagrilintide backbone (non-acylated)	9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
13.79	Single	9BUD	Cagrilintide	9BUD-CT-Cagrilintide-Gs/β1/γ2
13.79	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
13.79	Consensus	neuromedin-u_on	Orthosteric Ligand	nmur1_on nmur2_on
13.64	Single	4NTJ	AZD1283	4NTJ-P2Y₁₂-AZD1283
13.64	Single	4PHU	Fasiglifam	4PHU-FFA1-Fasiglifam
13.64	Single	5IUA	Q27456348	5IUA-A_2A-Q27456348-Na
13.64	Single	6LPL	ZM-241385	6LPL-A_2A-ZM-241385-Na
13.64	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
13.64	Single	6RZ4	Pranlukast	6RZ4-CysLT₁-Pranlukast-Na
13.64	Single	6S0Q	ZM-241385	6S0Q-A_2A-ZM-241385
13.64	Single	6WQA	ZM-241385	6WQA-A_2A-ZM-241385-Na
13.64	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/β1/γ2
13.64	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
13.64	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.64	Single	7RM5	ZM-241385	7RM5-A_2A-ZM-241385-Na
13.64	Single	7VV4	Cortistatin-14	7VV4-MRGPRX2-Cortistatin-14
13.64	Single	8EJC	TAK-875	8EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.64	Single	8FYN	ZM-241385	8FYN-A_2A-ZM-241385-Na
13.64	Single	8QOT	Nanobody-E	8QOT-μ-Nanobody-E
13.64	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
13.64	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
13.51	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
13.51	Consensus	glucagon_on_gp	Orthosteric Ligand	glp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
13.33	Single	5MZP	Caffeine	5MZP-A_2A-Caffeine-Na
13.33	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/β1/γ2
13.33	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
13.33	Single	8WCB	Cyclohexylammonium Ion	8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33	Consensus	calcitonin_on	Orthosteric Ligand	ctlike_on
13.33	Consensus	neuromedin-u_on_gp	Orthosteric Ligand	nmur1_on_gp nmur2_on_gp
13.33	Consensus	pac_on	Orthosteric Ligand	pac1_on
13.33	Consensus	vpac_on	Orthosteric Ligand	vpac1_on vpac2_on
13.04	Single	5TZR	MK8666	5TZR-FFA1-MK8666
13.04	Single	6OS1	TRV026	6OS1-AT₁-TRV026
13.04	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
13.04	Single	7PX4	PSB-2113	7PX4-A_2A-PSB-2113
13.04	Single	7R0C	AVP	7R0C-V₂-AVP-Arrestin2
13.04	Single	7S8M	Cortistatin-14	7S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
13.04	Single	7T9N	DPPC	7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
13.04	Single	7XBD	Galanin	7XBD-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04	Single	7Y67	C089 peptide	7Y67-C5a₁-C089 peptide-Gi1/β1/γ2
13.04	Single	8GDB	PGE2	8GDB-EP₄-PGE2-Gs/β1/γ2
13.04	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
13.04	Single	8JD5	JNJ-40411813; ADX88178	8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
13.04	Single	8WJX	ADP	8WJX-P2Y₁-ADP-chim(Gs-CtGq)/β1/γ2
13.04	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
13.04	Single	8XQT	Cholesterol	8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
13.04	Single	9CLW	TUG-1375	9CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.04	Consensus	ffa_on	Orthosteric Ligand	ffa2_on ffa3_on
13.04	Consensus	ffa_on_gp	Orthosteric Ligand	ffa2_on_gp ffa3_on_gp
13.04	Consensus	gi_ffa	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
12.90	Single	6NBF	Long-Acting PTH Analog	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
12.90	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
12.90	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/β1/γ2
12.90	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
12.90	Single	9J1P	g1:Ox	9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
12.90	Consensus	calcitonin_on_gp	Orthosteric Ligand	ctlike_on_gp
12.90	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
12.90	Consensus	crf2_on_gp	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
12.90	Consensus	vpac_on_gp	Orthosteric Ligand	vpac1_on_gp vpac2_on_gp
12.82	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on vip-pacap_on pth_on crf_on calcitonin_on
12.50	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
12.50	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
12.50	Single	5MZJ	Theophylline	5MZJ-A_2A-Theophylline-Na
12.50	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/β1/γ2
12.50	Single	6OS2	TRV026	6OS2-AT₁-TRV026
12.50	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
12.50	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
12.50	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
12.50	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/β1/γ2
12.50	Single	7WQ4	Galanin	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Single	7XJK	Galanin	7XJK-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
12.50	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
12.50	Single	8PWN	Theophylline	8PWN-A_2A-Theophylline
12.50	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/β1/γ2
12.50	Single	8XQN	Cholesterol	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
12.50	Single	8Y6W	TUG-1375	8Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
12.50	Single	9CM3	TUG-1375	9CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50	Consensus	ffa2_on_gp	Orthosteric Ligand	8J22-FFA2-TUG-1375-Gi1/β1/γ2
12.50	Consensus	galanin_on	Orthosteric Ligand	gal2_on gal1_on
12.50	Consensus	galanin_on_gp	Orthosteric Ligand	gal2_on_gp gal1_on_gp
12.12	Single	6LML	Glucagon	6LML-Glucagon-Glucagon-Gi1/β1/γ1
12.12	Single	9BQ3	Cagrilintide	9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
12.12	Single	9BTW	Cagrilintide	9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
12.12	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
12.12	Consensus	vpac2_on_gp	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
12.00	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
12.00	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
12.00	Single	7P00	Substance-P	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00	Single	8HN1	Toxin AdTx1	8HN1-Alpha1A-Toxin AdTx1
12.00	Single	8ZX4	Lysophosphatidylinositol	8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
12.00	Single	9C0K	Exendin-4	9C0K-GLP-1-Exendin-4-Gs/β1/γ2
12.00	Single	9GE3	Lysophosphatidylinositol	9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
12.00	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
12.00	Consensus	ccka_on_gp	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
12.00	Consensus	gal2_on	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00	Consensus	gal2_on_gp	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00	Consensus	nk1_on	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00	Consensus	nk1_on_gp	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76	Single	3RFM	Caffeine	3RFM-A_2A-Caffeine
11.76	Single	6OT0	25(S)-Epoxycholesterol	6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
11.76	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
11.76	Single	8A2O	Theophylline	8A2O-A_2A-Theophylline-Na
11.76	Consensus	gip_on	Orthosteric Ligand	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
11.76	Consensus	gip_on_gp	Orthosteric Ligand	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
11.54	Single	7RMG	Substance-P	7RMG-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
11.54	Single	7RMH	Substance-P	7RMH-NK₁-Substance-P-Gs/β1/γ2
11.54	Single	7S8L	Cortistatin-14	7S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/β1/γ2
11.54	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54	Single	8XQO	Cholesterol	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
11.54	Single	9CM7	TUG-1375	9CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
11.54	Single	9EAJ	Nanobody AT209	9EAJ-AT₁-Nanobody AT209
11.54	Single	9JH6	C20:0 Ceramide	9JH6-CysLT₂-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	2ZIY	11-cis-Retinal	2ZIY-Rhodopsin-11-cis-Retinal
11.11	Single	6FK9	PubChem 132473036	6FK9-Rhodopsin-PubChem 132473036
11.11	Single	6OIK	LY2119620	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
11.11	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
11.11	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
11.11	Single	7NA7	Ghrelin-27	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
11.11	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/β1/γ2
11.11	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
11.11	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
11.11	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
11.11	Single	8RQL	Flufenamic acid	8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
11.11	Single	8X9U	Metenolone	8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
11.11	Single	8YWF	Retatrutide	8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
11.11	Single	9JHJ	C18:0 Ceramide	9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
11.11	Consensus	nk3_on	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Consensus	nk3_on_gp	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Consensus	somatostatin_off	Orthosteric Ligand	sst2_off
10.81	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/β1/γ2
10.71	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
10.71	Single	7RMI	Substance-P	7RMI-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
10.71	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
10.71	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71	Single	8IOC	Gamma-MSH	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.71	Single	8JBH	Substance-P	8JBH-NK₃-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71	Single	8K6O	Pro-neuropeptide-Y	8K6O-Y₁-Pro-neuropeptide-Y-Gi2/β1/γ1
10.71	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
10.71	Consensus	tachykinin_on_gp	Orthosteric Ligand	nk1_on_gp nk2_on_gp nk3_on_gp
10.53	Single	5L7I	Vismodegib	5L7I-SMO-Vismodegib
10.53	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
10.53	Single	6PGS	Geraniol	6PGS-Rhodopsin-Geraniol-Gt(CT)
10.53	Single	7XKF	Beta-Hydroxyandrosterone	7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
10.53	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/β1/γ2
10.53	Single	8RWH	StilSwitch2	8RWH-A_2A-StilSwitch2-Na
10.53	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab
10.53	Single	8YKD	Dehydroepiandrosterone	8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
10.53	Consensus	gluc_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
10.53	Consensus	gq_nucleotide	Orthosteric Ligand	gq_p2y
10.53	Consensus	gq_p2y	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.34	Single	7W55	Neuromedin-U-25	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34	Single	9IVM	GLP-1 (Truncated)	9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
10.34	Consensus	class-b1_class-b2_cons_on	Orthosteric Ligand	class-b1_on class-b2_on
10.34	Consensus	class-b1_class-b2_cons_on_gp	Orthosteric Ligand	class-b1_on_gp class-b2_on_gp
10.34	Consensus	nmur2_on	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34	Consensus	nmur2_on_gp	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.26	Consensus	gluc_on_gp	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
10.00	Single	3PWH	ZM-241385	3PWH-A_2A-ZM-241385
10.00	Single	3VG9	ZM-241385	3VG9-A_2A-ZM-241385-Antibody
10.00	Single	5K2D	ZM-241385	5K2D-A_2A-ZM-241385-Na
10.00	Single	5OLH	Vipadenant	5OLH-A_2A-Vipadenant-Na
10.00	Single	5OLO	Tozadenant	5OLO-A_2A-Tozadenant-Na
10.00	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
10.00	Single	6JZH	ZM-241385	6JZH-A_2A-ZM-241385-Na
10.00	Single	6NIY	Adrenomedullin	6NIY-CT-Adrenomedullin-Gs/β1/γ2
10.00	Single	6PS7	ZM-241385	6PS7-A_2A-ZM-241385-Na
10.00	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
10.00	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
10.00	Single	7VDL	Cortistatin-14	7VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
10.00	Single	7VVO	PTH	7VVO-PTH1-PTH-Gs/β1/γ2
10.00	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/β1/γ2
10.00	Single	8DWH	PubChem 139030531	8DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
10.00	Single	8HMP	C17	8HMP-GPR52-C17-Gs/β1/γ2
10.00	Single	8RVW	StilSwitch3	8RVW-A_2A-StilSwitch3-Na
10.00	Single	8RW4	AzoSwitch2	8RW4-A_2A-AzoSwitch2-Na
10.00	Single	8RWE	StilSwitch4	8RWE-A_2A-StilSwitch4-Na
10.00	Single	8T3V	Docosa-4,7,10,13,16,19-Hexaenoic acid	8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00	Single	8U8F	Palmitic Acid	8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
10.00	Single	8YYW	Alpha-ketoglutarate	8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
10.00	Single	9FUP	Istradefylline	9FUP-A_2A-Istradefylline-Na
10.00	Consensus	p2y1_on	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.00	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on nk3_on
9.68	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
9.68	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/β1/γ2
9.52	Single	3REY	XAC	3REY-A_2A-XAC
9.52	Single	5IU4	ZM-241385	5IU4-A_2A-ZM-241385-Na
9.52	Single	5IUB	Q27456344	5IUB-A_2A-Q27456344-Na
9.52	Single	5K2C	ZM-241385	5K2C-A_2A-ZM-241385-Na
9.52	Single	5NLX	ZM-241385	5NLX-A_2A-ZM-241385-Na
9.52	Single	5NM4	ZM-241385	5NM4-A_2A-ZM-241385-Na
9.52	Single	5UVI	ZM-241385	5UVI-A_2A-ZM-241385
9.52	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
9.52	Single	6U1N	LY2119620	6U1N-M₂-LY2119620-Arrestin2
9.52	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.52	Single	7UTZ	DPPC	7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
9.52	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/β1/γ2
9.52	Single	8X7A	Treprostinil	8X7A-I2-Treprostinil-Gs/β1/γ2
9.52	Single	8YRG	Fospropofol	8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
9.38	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
9.38	Single	9BUB	Cagrilintide	9BUB-CT-Cagrilintide-Gs/β1/γ2
9.38	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
9.09	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
9.09	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
9.09	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
9.09	Single	6LPJ	ZM-241385	6LPJ-A_2A-ZM-241385-Na
9.09	Single	6LPK	ZM-241385	6LPK-A_2A-ZM-241385-Na
9.09	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/β1/γ2
9.09	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/β1/γ2
9.09	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
9.09	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
9.09	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/β1/γ2
9.09	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
9.09	Single	8XBG	S3E-LysoPS	8XBG-GPR34-S3E-LysoPS
9.09	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/β1/γ2
9.09	Consensus	glp2_on_gp	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/β1/γ2
8.82	Consensus	ctlike_on_gp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
8.70	Single	5ZBQ	UR-MK-299	5ZBQ-Y₁-UR-MK-299
8.70	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.70	Single	7VV0	PAMP-12	7VV0-MRGPRX2-PAMP-12
8.70	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
8.70	Consensus	adgrg2_on	Orthosteric Ligand	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
8.70	Consensus	adgrg2_on_gp	Orthosteric Ligand	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
8.70	Consensus	cxcr2_on_gp	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.70	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off cyslt1_off
8.33	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/β1/γ2
8.33	Single	7XJL	Spexin	7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33	Single	7XWO	Neurokinin-A	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33	Single	8JBG	Neurokinin-B	8JBG-NK₃-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33	Single	9ITE	LPA	9ITE-LPA₆-LPA-chim(NtGi2-G13)/β1/γ2
8.33	Consensus	ffa2_on	Orthosteric Ligand	8J22-FFA2-TUG-1375-Gi1/β1/γ2
8.33	Consensus	nk2_on_gp	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
8.33	Consensus	p2y12_on	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
8.11	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/β1/γ2
8.00	Single	6RZ7	ONO-2570366	6RZ7-CysLT₂-ONO-2570366
8.00	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/β1/γ2
8.00	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
8.00	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
8.00	Consensus	gi_p2y	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
8.00	Consensus	p2y12_on_gp	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
7.89	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/β1/γ2
7.69	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
7.69	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/β1/γ2
7.69	Single	8K4O	CXCL1	8K4O-KSHV-CXCL1-Gi1/β1/γ1
7.69	Single	8XBE	S3E-LysoPS	8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
7.69	Consensus	cyslt2_off	Orthosteric Ligand	6RZ7-CysLT₂-ONO-2570366 6RZ8-CysLT₂-ONO-2080365 6RZ9-CysLT₂-ONO-2770372
7.41	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
7.41	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/β1/γ2
7.41	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/β1/γ2
7.41	Single	8SAI	1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine	8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
7.41	Single	8Z74	Agonistic antibody	8Z74-Apelin-Agonistic antibody
7.41	Single	8Z74	Agonistic antibody	8Z74-Apelin-Agonistic antibody
7.41	Single	9ITB	LPA	9ITB-LPA₆-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/β1/γ2
7.14	Single	9BUE	Cagrilintide	9BUE-CT-Cagrilintide-Gs/β1/γ2
6.90	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
6.25	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
6.06	Single	6NBI	Long-Acting PTH Analog	6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
5.88	Single	7V68	LY2119620	7V68-M₄-Iperoxo-LY2119620-Gi1/β1/γ2
5.88	Single	7XKE	Beta-Hydroxyandrosterone	7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
5.88	Single	8HVI	NOX-6-7	8HVI-GPR132-NOX-6-7-Gi1/β1/γ2
5.88	Single	8X9S	5alpha-DHT	8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
5.71	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/β1/γ2
5.26	Single	7V6A	PubChem 9864275	7V6A-M₄-PubChem 9864275-Gi1/β1/γ2
5.26	Single	8F76	Propanoic acid	8F76-OR51E2-Propanoic acid-Gs/β1/γ2
5.13	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/β1/γ2
5.00	Single	6LI0	C17	6LI0-GPR52-C17
4.76	Single	4K5Y	CP-376395	4K5Y-CRF₁-CP-376395
4.76	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
4.76	Single	6ZA8	RTI-3a	6ZA8-NTS₁-RTI-3a
4.76	Single	8H8J	Lodoxamide	8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
4.76	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
4.55	Single	6ZIN	SR48692	6ZIN-NTS₁-SR48692
4.55	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
4.55	Single	8HJ5	PubChem 139030531	8HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	8IYX	YL-365	8IYX-GPR34-YL-365
4.55	Single	8JD6	VU0364770	8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
4.55	Single	9DQJ	EP-3945	9DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	9IXX	LTD4	9IXX-CysLT₂-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	9K0K	UTP	9K0K-P2Y₄-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	9K0X	ATP	9K0X-P2Y₂-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	9K20	ATP	9K20-P2Y₂-ATP-chim(NtGi1-Go)/β1/γ2
4.55	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
4.35	Single	4QIM	ANTA XV	4QIM-SMO-ANTA XV
4.35	Single	4Z9G	CP-376395	4Z9G-CRF₁-CP-376395
4.35	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
4.35	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
4.35	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
4.35	Single	8GTI	BMK-C205	8GTI-CRF₁-BMK-C205
4.35	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
4.35	Single	8ZYY	Neurotensin peptide 8-13	8ZYY-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
4.35	Single	9IVG	GLP-1 (Truncated)	9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
4.35	Consensus	cxcr1_on_gp	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
4.17	Single	4JKV	Taladegib	4JKV-SMO-Taladegib
4.17	Single	6Z4Q	SR142948A	6Z4Q-NTS₁-SR142948A
4.17	Single	6Z4S	SR48692	6Z4S-NTS₁-SR48692
4.17	Single	8GTG	BMK-I152	8GTG-CRF₁-BMK-I152
4.17	Single	8JGG	BAM8-22	8JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
4.17	Single	8XQP	Cholesterol	8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.17	Single	9DQH	EP-2825	9DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
4.00	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
4.00	Single	5V56	TC114	5V56-SMO-TC114
4.00	Single	5V57	TC114	5V57-SMO-TC114
4.00	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
4.00	Single	6Z8N	SRI-9829	6Z8N-NTS₁-SRI-9829
4.00	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
4.00	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/β1/γ1
4.00	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/β1/γ1
4.00	Single	8FMZ	Neurotensin/Neuromedin-N	8FMZ-NTS₁-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00	Single	8FN1	Neurotensin/Neuromedin-N	8FN1-NTS₁-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
4.00	Single	8JD5	JNJ-40411813; ADX88178	8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
4.00	Single	8JGF	BAM8-22	8JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Consensus	neurotensin_on	Orthosteric Ligand	nts1_on
4.00	Consensus	nts1_on	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
3.85	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
3.85	Single	4GRV	Neurotensin-(8-13)	4GRV-NTS₁-Neurotensin-(8-13)
3.85	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
3.85	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
3.85	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/β1/γ2
3.85	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
3.85	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
3.85	Single	8DWC	Proenkephalin-A	8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85	Single	8GTM	BMK-C203	8GTM-CRF₁-BMK-C203
3.85	Single	8JPB	Neurotensin-(8-13)	8JPB-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
3.85	Single	8JPC	Neurotensin-(8-13)	8JPC-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
3.85	Consensus	gi_neurotensin	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
3.85	Consensus	neurotensin_on_gp	Orthosteric Ligand	nts1_on_gp
3.85	Consensus	nts1_on_gp	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
3.70	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
3.70	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-SBI-553
3.70	Single	8XVU	CXCL2	8XVU-CXCR2-CXCL2
3.70	Single	8XXH	CXCL2	8XXH-CXCR2-CXCL2-Go/β1/γ2
3.70	Single	9JH5	C16:0 Ceramide	9JH5-CysLT₂-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
3.57	Single	8XQJ	JN241	8XQJ-Apelin-JN241
3.57	Single	8XX6	CXCL8	8XX6-CXCR2-CXCL8-Go/β1/γ2
3.45	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/β1/γ1
3.45	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.45	Single	8DWG	Proenkephalin-A	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.45	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/β1/γ2
3.45	Single	8XWN	CXCL8	8XWN-CXCR2-CXCL8
3.45	Consensus	ccr1_on	Orthosteric Ligand	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.45	Consensus	ccr1_on_gp	Orthosteric Ligand	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.03	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue

PDB Summary
PDB	8EF5
Class	A
SubFamily	Peptide
Type	Opioid
SubType	MOP
Species	Homo Sapiens
Ligand	Fentanyl
Other Ligand(s)	-
Protein Partners	Gi1/Beta1/Gamma2
PDB Resolution	3.3
Date	2022-11-09
D.O.I.	doi.org/10.1016/j.cell.2022.09.041

Net Summary
I_min	2.44
Number of Linked Nodes	835
Number of Links	1060
Number of Hubs	197
Number of Links mediated by Hubs	698
Number of Communities	28
Number of Nodes involved in Communities	288
Number of Links involved in Communities	432

Path Summary
Number Of Nodes in MetaPath	107
Number Of Links MetaPath	106
Number of Shortest Paths	3706051
Length Of Smallest Path	3
Average Path Length	32.7895
Length of Longest Path	56
Minimum Path Strength	1.36
Average Path Strength	5.52323
Maximum Path Strength	20.665
Minimum Path Correlation	0.7
Average Path Correlation	0.989917
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.7027
Average % Of Corr. Nodes	37.4719
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	60.0766
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • calcium channel activity • monoatomic cation transmembrane transporter activity • voltage-gated calcium channel activity • gated channel activity • monoatomic ion channel activity • voltage-gated channel activity • voltage-gated monoatomic ion channel activity • voltage-gated monoatomic cation channel activity • monoatomic cation channel activity • passive transmembrane transporter activity • calcium ion transmembrane transporter activity • channel activity • monoatomic ion transmembrane transporter activity • transporter activity • metal ion transmembrane transporter activity • transmembrane transporter activity • protein binding • binding • G-protein beta-subunit binding • neuropeptide binding • peptide binding • G-protein alpha-subunit binding • peptide receptor activity • beta-endorphin receptor activity • G protein-coupled opioid receptor activity • G protein-coupled peptide receptor activity • melanocortin receptor activity • neuropeptide receptor activity • morphine receptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • cellular response to nitrogen compound • synaptic signaling • cellular response to acetylcholine
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • cellular response to nitrogen compound • synaptic signaling • cellular response to acetylcholine • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to acetylcholine • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of cellular process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • regulation of localization • transport • regulation of signaling receptor activity • regulation of transmembrane transporter activity • localization • regulation of NMDA receptor activity • regulation of transport • establishment of localization • transmembrane transport • regulation of molecular function • regulation of transmembrane transport • regulation of neurotransmitter receptor activity • G protein-coupled opioid receptor signaling pathway • regulation of cellular response to stress • cellular response to stress • regulation of response to stress • response to stress • regulation of biosynthetic process • regulation of nitric oxide biosynthetic process • negative regulation of metabolic process • negative regulation of biological process • reactive nitrogen species metabolic process • nitric oxide metabolic process • nitric oxide biosynthetic process • biosynthetic process • negative regulation of nitric oxide biosynthetic process • negative regulation of biosynthetic process • negative regulation of cellular process • metabolic process • regulation of nitric oxide metabolic process • regulation of metabolic process • multicellular organismal process • system process • sensory perception • nervous system process • behavior • adult behavior • response to alcohol • behavioral response to ethanol • response to ethanol • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • regulation of biological quality • negative regulation of cytosolic calcium ion concentration • positive regulation of nervous system development • regulation of developmental process • cellular developmental process • cell development • regulation of cell differentiation • regulation of neurogenesis • regulation of cell development • regulation of nervous system development • positive regulation of developmental process • multicellular organism development • neurogenesis • positive regulation of cell differentiation • cell differentiation • anatomical structure development • positive regulation of neurogenesis • regulation of multicellular organismal process • system development • developmental process • regulation of multicellular organismal development • positive regulation of cell development • nervous system development • positive regulation of multicellular organismal process • sensory perception of pain • negative regulation of protein transport • establishment of protein localization • nitrogen compound transport • regulation of protein localization • negative regulation of signaling • negative regulation of Wnt protein secretion • negative regulation of transport • negative regulation of cell communication • protein localization to extracellular region • secretion by cell • regulation of secretion by cell • negative regulation of secretion • signal release • negative regulation of secretion by cell • intracellular protein localization • regulation of Wnt protein secretion • negative regulation of protein localization • secretion • establishment of protein localization to extracellular region • regulation of establishment of protein localization • export from cell • negative regulation of establishment of protein localization • regulation of protein transport • Wnt protein secretion • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • protein transport • macromolecule localization • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • somatodendritic compartment • cell body • cellular anatomical structure • perikaryon • neuronal cell body • cell periphery • plasma membrane • membrane • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle
Gene Ontology	Cellular Component	• somatodendritic compartment • cell body • cellular anatomical structure • perikaryon • neuronal cell body • cell periphery • plasma membrane • membrane • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • Golgi apparatus • organelle • cytoplasm • intracellular membrane-bounded organelle • endomembrane system • endosome • intracellular vesicle • cytoplasmic vesicle • vesicle • synapse • cell junction • axon • endoplasmic reticulum • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • cilium • ciliary basal body • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • plasma membrane region • cell projection membrane • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	7V7
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	7V7
Name	Fentanyl
Synonyms	Fentanyl CII
Identifier
Formula	C22 H28 N2 O
Molecular Weight	336.471
SMILES
PubChem	3345
Formal Charge	0
Total Atoms	53
Total Chiral Atoms	0
Total Bonds	55
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35372
Sequence	>8EF5_Chain_R S M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T K M K T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G T W P F G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H P V K A L D F R T P R N A K I I N V C N W I L S S A I G L P V M F M A T T K Y R Q G S I D C T L T F S H P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V R M L S G S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T I P E T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F K R C F R E F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	A
Protein	G Protein α Sub unit
UniProt	P63096
Sequence	>8EF5_Chain_A T L S A E D K A A V E R S K M I D R N L R E D G E K A A R E V K L L L L G A G E S G K S T I V K Q M K I T G I V E T H F T F K D L H F K M F D V G A Q R S E R K K W I H C F E G V T A I I F C V A L S D Y D L V L A E D E E M N R M H E S M K L F D S I C N N K W F T D T S I I L F L N K K D L F E E K I K K S P L T I C Y P E Y A G S N T Y E E A A A Y I Q C Q F E D L N K R K D T K E I Y T H F T C S T D T K N V Q F V F D A V T D V I I K N N L K D C G L F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	B
Protein	G Protein β Sub unit
UniProt	P54311
Sequence	>8EF5_Chain_B D Q L R Q E A E Q L K N Q I R D A R K A C A D A T L S Q I T N N I D P V G R I Q M R T R R T L R G H L A K I Y A M H W G T D S R L L V S A S Q D G K L I I W D S Y T T N K V H A I P L R S S W V M T C A Y A P S G N Y V A C G G L D N I C S I Y N L K T R E G N V R V S R E L A G H T G Y L S C C R F L D D N Q I V T S S G D T T C A L W D I E T G Q Q T T T F T G H T G D V M S L S L A P D T R L F V S G A C D A S A K L W D V R E G M C R Q T F T G H E S D I N A I C F F P N G N A F A T G S D D A T C R L F D L R A D Q E L M T Y S H D N I I C G I T S V S F S K S G R L L L A G Y D D F N C N V W D A L K A D R A G V L A G H D N R V S C L G V T D D G M A V A T G S W D S F L K I W N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	G
Protein	G Protein γ Sub unit
UniProt	P63212
Sequence	>8EF5_Chain_G I A Q A R K L V E Q L K M E A N I D R I K V S K A A A D L M A Y C E A H A K E D P L L T P V P A S E N P F R E K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This network is also present in following consensuses:
	Id	Components
	mop_on	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
	mop_on_gp	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
	gi_opioid	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9BJK	A	Peptide	Opioid	μ	Mus musculus	Naloxone	NAM	-	3.26	2024-07-17	doi.org/10.1038/s41586-024-07587-7
	8K9L	A	Peptide	Opioid	μ	Homo sapiens	Damgo	BMS-986122	Gi3/β1/γ1	3.05	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9L (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Damgo	BMS-986122		3.05	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	7SBF	A	Peptide	Opioid	μ	Mus musculus	PZM21	-	Gi1/β1/γ2	2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SBF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	PZM21	-		2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG	A	Peptide	Opioid	μ	Mus musculus	FH210	-	Gi1/β1/γ2	3	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	FH210	-		3	2022-04-20	doi.org/10.1002/anie.202200269
	8EF5 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-		3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF6	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF6 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFB	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFB (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFL	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFL (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-	Gi1/β1/γ2	2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-		2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFQ	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-	Gi1/β1/γ2	3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFQ (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-		3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8F7Q	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-	Gi1/β1/γ2	3.22	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7Q (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-		3.22	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7R	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	Gi1/β1/γ2	3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7R (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	9BQJ	A	Peptide	Opioid	μ	Mus musculus	RO76	-	Gi1/β1/γ2	3.3	2024-09-11	doi.org/10.1021/acscentsci.4c00525
	9BQJ (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	RO76	-		3.3	2024-09-11	doi.org/10.1021/acscentsci.4c00525
	4DKL	A	Peptide	Opioid	μ	Mus musculus	β-Funaltrexamine	-	-	2.8	2012-03-21	doi.org/10.1038/nature10954
	5C1M	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.07	2015-08-05	doi.org/10.1038/nature14886
	8K9K	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-	Gi3/β1/γ1	2.98	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9K (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-		2.98	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	6DDE	A	Peptide	Opioid	μ	Mus musculus	Damgo	-	Gi1/β1/γ2	3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDE (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Damgo	-		3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDF	A	Peptide	Opioid	μ	Mus musculus	Damgo	-	Gi1/β1/γ2	3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Damgo	-		3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	7U2L	A	Peptide	Opioid	μ	Mus musculus	PubChem 163201242	-	Gi1/β1/γ2	3.2	2022-05-04	doi.org/10.1038/s41586-022-05588-y
	7U2L (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	PubChem 163201242	-		3.2	2022-05-04	doi.org/10.1038/s41586-022-05588-y
	7U2K	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-	Gi1/β1/γ2	3.3	2022-12-07	doi.org/10.1038/s41586-022-05588-y
	7U2K (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-		3.3	2022-12-07	doi.org/10.1038/s41586-022-05588-y
	7T2G	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-	Gi1/β1/γ2	2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2G (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-		2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2H	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-	Gi1/β1/γ2	2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2H (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-		2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7UL4	A	Peptide	Opioid	μ	Mus musculus	Alvimopan	-	-	2.8	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	8QOT	A	Peptide	Opioid	μ	Mus musculus	Nanobody-E	-	-	3.2	2023-12-27	doi.org/10.1101/2023.12.06.570395
	9MQH	A	Peptide	Opioid	μ	Homo sapiens	-	-	-	3.9	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQI	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.3	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQJ	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.23	2025-02-12	doi.org/10.1101/2025.01.09.632033
	8E0G	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.1	2023-10-18	doi.org/10.1186/s12915-023-01689-w
	8Y73	A	Peptide	Opioid	μ	Homo sapiens	Peptide	MPAM-15	Gi1/β1/γ2	2.84	2025-08-06	To be published
	8Y73 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Peptide	MPAM-15		2.84	2025-08-06	To be published
	8Y72	A	Peptide	Opioid	μ	Homo sapiens	Peptide	BMS-986122	Gi1/β1/γ2	2.65	2025-08-06	To be published
	8Y72 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Peptide	BMS-986122		2.65	2025-08-06	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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