psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I71	R:R:L67	4.28	No	No	0	4	3
2	R:R:L67	R:R:V316	4.47	No	No	0	3	1
3	R:R:I71	R:R:Y128	20.55	No	No	1	4	5
4	R:R:H319	R:R:I71	15.91	Yes	No	1	4	4
5	R:R:S125	R:R:T72	4.8	No	No	0	6	5
6	R:R:L129	R:R:T72	14.74	No	No	0	5	5
7	R:R:A323	R:R:L74	4.73	No	No	0	4	5
8	R:R:H319	R:R:Y75	10.89	Yes	Yes	1	4	7
9	R:R:I322	R:R:Y75	9.67	Yes	Yes	1	5	7
10	L:L:?1	R:R:Y75	12.45	Yes	Yes	1	0	7
11	R:R:T327	R:R:V78	4.76	No	No	0	5	7
12	R:R:C79	R:R:L121	4.76	No	No	0	6	7
13	R:R:C79	R:R:P122	7.53	No	No	0	6	8
14	R:R:C330	R:R:V81	6.83	No	No	0	7	5
15	R:R:G82	R:R:T118	5.46	No	No	0	8	6
16	R:R:F87	R:R:L83	7.31	No	No	0	4	6
17	R:R:L83	R:R:T118	5.9	No	No	0	6	6
18	R:R:G85	R:R:P333	4.06	No	No	0	7	9
19	R:R:A111	R:R:N86	4.69	No	No	0	9	9
20	R:R:D114	R:R:N86	9.42	Yes	No	0	9	9
21	R:R:N86	R:R:P333	11.4	No	No	0	9	9
22	R:R:F338	R:R:L88	4.87	No	No	0	6	6
23	R:R:A337	R:R:V89	5.09	No	No	0	7	9
24	R:R:F338	R:R:V89	5.24	No	No	0	6	9
25	R:R:F108	R:R:M90	11.2	No	No	0	6	7
26	R:R:L112	R:R:M90	5.65	No	No	0	6	7
27	R:R:R95	R:R:Y91	10.29	No	No	0	4	4
28	R:R:F350	R:R:Y91	4.13	No	No	0	5	4
29	R:R:V92	R:R:Y96	6.31	No	No	0	7	5
30	R:R:I93	R:R:T97	4.56	Yes	Yes	2	7	6
31	R:R:I93	R:R:M99	4.37	Yes	No	2	7	7
32	R:R:F108	R:R:I93	6.28	No	Yes	2	6	7
33	R:R:F343	R:R:I93	6.28	Yes	Yes	2	9	7
34	R:R:R95	R:R:Y96	15.43	No	No	0	4	5
35	R:R:E349	R:R:Y96	8.98	No	No	0	4	5
36	R:R:N104	R:R:T97	8.77	No	Yes	2	8	6
37	R:R:F343	R:R:T97	14.27	Yes	Yes	2	9	6
38	R:R:F108	R:R:M99	17.42	No	No	2	6	7
39	R:R:N104	R:R:T101	8.77	No	No	0	8	8
40	R:R:F343	R:R:N104	6.04	Yes	No	2	9	8
41	R:R:A184	R:R:I105	4.87	No	Yes	0	7	6
42	R:R:I105	R:R:K185	4.36	Yes	No	0	6	2
43	R:R:I105	R:R:N188	4.25	Yes	No	0	6	7
44	R:R:T160	R:R:Y106	7.49	No	Yes	0	7	7
45	R:R:M161	R:R:Y106	5.99	No	Yes	0	8	7
46	R:R:D164	R:R:Y106	13.79	No	Yes	0	8	7
47	R:R:A184	R:R:Y106	6.67	No	Yes	0	7	7
48	R:R:V187	R:R:Y106	6.31	No	Yes	0	5	7
49	R:R:N188	R:R:Y106	8.14	No	Yes	0	7	7
50	R:R:I107	R:R:M161	4.37	No	No	0	8	8
51	R:R:F343	R:R:I107	6.28	Yes	No	0	9	8
52	R:R:N109	R:R:T157	11.7	No	No	0	9	7
53	R:R:N109	R:R:N188	16.35	No	No	0	9	7
54	R:R:N109	R:R:W192	14.69	No	Yes	0	9	9
55	R:R:D114	R:R:L110	10.86	Yes	Yes	3	9	9
56	R:R:L110	R:R:T157	5.9	Yes	No	0	9	7
57	R:R:L110	R:R:L158	5.54	Yes	No	3	9	8
58	R:R:L110	R:R:N332	12.36	Yes	Yes	3	9	9
59	R:R:L110	R:R:Y336	4.69	Yes	Yes	3	9	9
60	R:R:L112	R:R:L116	5.54	No	No	0	6	7
61	R:R:L112	R:R:W192	5.69	No	Yes	0	6	9
62	R:R:D114	R:R:S154	4.42	Yes	No	0	9	9
63	R:R:D114	R:R:S329	10.31	Yes	No	0	9	9
64	R:R:D114	R:R:N332	12.12	Yes	Yes	3	9	9
65	R:R:L116	R:R:N150	13.73	No	No	0	7	8
66	R:R:L121	R:R:T118	4.42	No	No	0	7	6
67	R:R:D147	R:R:T120	7.23	No	No	0	6	6
68	R:R:L121	R:R:Y326	17.58	No	No	0	7	7
69	R:R:F123	R:R:F135	13.93	No	Yes	0	6	7
70	R:R:F123	R:R:V143	10.49	No	No	0	6	5
71	L:L:?1	R:R:Q124	24.95	Yes	No	0	0	6
72	R:R:M130	R:R:V126	4.56	No	No	0	3	5
73	R:R:F135	R:R:V126	6.55	Yes	No	0	7	5
74	R:R:N127	R:R:W133	13.56	No	Yes	0	6	8
75	R:R:H319	R:R:Y128	14.16	Yes	No	1	4	5
76	R:R:M130	R:R:T132	4.52	No	No	0	3	5
77	R:R:M130	R:R:P134	5.03	No	No	0	3	4
78	R:R:F135	R:R:W133	18.04	Yes	Yes	0	7	8
79	R:R:C140	R:R:W133	5.22	No	Yes	6	9	8
80	R:R:V143	R:R:W133	7.36	No	Yes	0	5	8
81	R:R:C217	R:R:W133	20.89	No	Yes	6	9	8
82	R:R:F135	R:R:P134	14.45	Yes	No	0	7	4
83	R:R:F135	R:R:L139	4.87	Yes	No	0	7	6
84	R:R:N137	R:R:T208	8.77	No	No	0	1	5
85	R:R:C140	R:R:C217	7.28	No	No	6	9	9
86	R:R:A206	R:R:I144	4.87	No	No	0	4	5
87	R:R:M203	R:R:S145	12.27	No	No	0	4	6
88	R:R:I146	R:R:N150	7.08	No	No	0	5	8
89	R:R:D147	R:R:Y326	11.49	No	No	1	6	7
90	L:L:?1	R:R:D147	24.59	Yes	No	1	0	6
91	R:R:V202	R:R:Y148	15.14	No	No	0	5	4
92	R:R:L232	R:R:Y148	7.03	No	No	0	5	4
93	L:L:?1	R:R:Y148	12.45	Yes	No	0	0	4
94	R:R:T153	R:R:Y149	7.49	Yes	No	4	7	4
95	R:R:W192	R:R:Y149	11.58	Yes	No	4	9	4
96	R:R:N150	R:R:W192	4.52	No	Yes	0	8	9
97	R:R:F152	R:R:M151	4.98	Yes	No	0	7	7
98	R:R:M151	R:R:V236	6.09	No	No	0	7	5
99	R:R:M151	R:R:W293	6.98	No	Yes	0	7	8
100	R:R:F152	R:R:F156	9.65	Yes	No	0	7	6
101	R:R:F152	R:R:I198	12.56	Yes	No	0	7	4
102	R:R:A240	R:R:F152	4.16	No	Yes	0	6	7
103	R:R:N191	R:R:T153	10.24	Yes	Yes	4	7	7
104	R:R:T153	R:R:W192	19.41	Yes	Yes	4	7	9
105	R:R:S195	R:R:T153	6.4	No	Yes	4	8	7
106	R:R:F289	R:R:I155	8.79	No	No	7	9	8
107	R:R:I155	R:R:W293	7.05	No	Yes	7	8	8
108	R:R:F156	R:R:N191	9.67	No	Yes	0	6	7
109	R:R:N191	R:R:T157	4.39	Yes	No	0	7	7
110	R:R:L158	R:R:N332	10.98	No	Yes	3	8	9
111	R:R:L158	R:R:Y336	10.55	No	Yes	3	8	9
112	R:R:C159	R:R:I247	4.91	No	No	0	7	7
113	R:R:C159	R:R:I248	4.91	No	No	0	7	8
114	R:R:M161	R:R:Y336	7.18	No	Yes	0	8	9
115	R:R:I248	R:R:S162	7.74	No	No	0	8	9
116	R:R:C251	R:R:S162	5.16	No	No	0	7	9
117	R:R:S162	R:R:Y252	15.26	No	Yes	0	9	9
118	R:R:D164	R:R:R179	15.48	No	No	0	8	6
119	R:R:R165	R:R:Y252	11.32	No	Yes	0	9	9
120	R:R:R165	R:R:Y336	5.14	No	Yes	0	9	9
121	R:R:C170	R:R:Y166	9.41	No	Yes	0	7	8
122	R:R:H171	R:R:Y166	8.71	No	Yes	0	6	8
123	R:R:C251	R:R:Y166	8.06	No	Yes	0	7	8
124	R:R:L254	R:R:Y166	8.21	No	Yes	0	4	8
125	R:R:A168	R:R:R179	5.53	No	No	0	8	6
126	R:R:M255	R:R:V169	7.61	No	No	0	8	8
127	R:R:L259	R:R:V169	4.47	No	No	0	8	8
128	R:R:C170	R:R:R258	4.18	No	No	0	7	5
129	R:R:N183	R:R:T180	8.77	No	No	0	4	7
130	R:R:N191	R:R:S195	4.47	Yes	No	4	7	8
131	R:R:L200	R:R:S196	6.01	No	No	0	3	3
132	R:R:L219	R:R:V202	5.96	No	No	0	5	5
133	R:R:F221	R:R:M205	4.98	Yes	No	0	5	4
134	R:R:K209	R:R:T207	9.01	Yes	No	8	3	5
135	R:R:T207	R:R:T220	6.28	No	No	8	5	4
136	R:R:K209	R:R:R211	4.95	Yes	No	0	3	3
137	R:R:K209	R:R:T218	7.51	Yes	No	0	3	3
138	R:R:K209	R:R:T220	7.51	Yes	No	8	3	4
139	R:R:I215	R:R:Y210	13.3	No	No	0	4	1
140	R:R:D216	R:R:S214	4.42	No	No	0	4	2
141	R:R:F221	R:R:L219	7.31	Yes	No	0	5	5
142	R:R:E229	R:R:F221	18.66	No	Yes	0	4	5
143	R:R:H223	R:R:S222	5.58	No	No	0	4	6
144	R:R:P224	R:R:W226	12.16	No	No	9	1	2
145	R:R:P224	R:R:Y227	4.17	No	Yes	9	1	3
146	R:R:W226	R:R:Y227	7.72	No	Yes	9	2	3
147	R:R:W228	R:R:Y227	17.36	No	Yes	0	3	3
148	R:R:E229	R:R:K233	5.4	No	Yes	0	4	4
149	R:R:K233	R:R:V300	4.55	Yes	No	0	4	5
150	R:R:C235	R:R:F239	5.59	No	No	0	3	4
151	R:R:F237	R:R:I242	11.3	No	No	0	5	5
152	R:R:F237	R:R:H297	4.53	No	Yes	0	5	8
153	R:R:F237	R:R:I301	8.79	No	No	0	5	6
154	R:R:F239	R:R:I238	10.05	No	No	0	4	4
155	R:R:F241	R:R:V245	5.24	No	No	0	8	6
156	R:R:F241	R:R:T294	11.67	No	Yes	0	8	5
157	R:R:F241	R:R:H297	18.1	No	Yes	0	8	8
158	R:R:M243	R:R:P244	6.71	No	No	0	5	9
159	R:R:I247	R:R:M243	5.83	No	No	0	7	5
160	R:R:F289	R:R:P244	5.78	No	No	0	9	9
161	R:R:I290	R:R:V245	4.61	No	No	0	5	6
162	R:R:M255	R:R:Y252	4.79	No	Yes	0	8	9
163	R:R:V282	R:R:Y252	8.83	No	Yes	0	7	9
164	R:R:I256	R:R:T279	6.08	No	No	0	5	6
165	R:R:I256	R:R:V282	7.68	No	No	0	5	7
166	R:R:L259	R:R:L265	5.54	No	Yes	5	8	3
167	R:R:M264	R:R:V262	6.09	No	No	5	5	6
168	R:R:L265	R:R:V262	4.47	Yes	No	5	3	6
169	R:R:L265	R:R:M264	8.48	Yes	No	5	3	5
170	R:R:L265	R:R:L275	6.92	Yes	No	0	3	6
171	R:R:K271	R:R:S268	7.65	No	No	0	4	4
172	R:R:E270	R:R:R273	8.14	No	No	0	2	4
173	R:R:R273	R:R:R276	5.33	No	No	0	4	5
174	R:R:N274	R:R:R277	4.82	No	No	0	5	7
175	R:R:R276	R:R:R280	8.53	No	No	0	5	6
176	R:R:E341	R:R:R277	6.98	No	No	0	4	7
177	R:R:L339	R:R:M281	5.65	No	No	0	6	8
178	R:R:L335	R:R:V285	4.47	No	No	0	8	8
179	R:R:V285	R:R:Y336	8.83	No	Yes	0	8	9
180	R:R:N328	R:R:V288	4.43	Yes	Yes	0	9	6
181	R:R:L331	R:R:V288	7.45	No	Yes	0	7	6
182	R:R:L335	R:R:V288	5.96	No	Yes	0	8	6
183	R:R:F289	R:R:W293	11.02	No	Yes	7	9	8
184	R:R:I290	R:R:T294	6.08	No	Yes	0	5	5
185	R:R:C292	R:R:N328	9.45	No	Yes	0	8	9
186	R:R:H297	R:R:W293	9.52	Yes	Yes	0	8	8
187	R:R:G325	R:R:W293	8.44	No	Yes	0	7	8
188	R:R:N328	R:R:W293	7.91	Yes	Yes	0	9	8
189	R:R:P295	R:R:T294	5.25	No	Yes	0	9	5
190	R:R:I296	R:R:W318	4.7	No	Yes	1	6	5
191	R:R:I296	R:R:I322	5.89	No	Yes	1	6	5
192	L:L:?1	R:R:I296	8.92	Yes	No	1	0	6
193	L:L:?1	R:R:H297	4.82	Yes	Yes	0	0	8
194	R:R:K303	R:R:Y299	8.36	No	Yes	1	4	4
195	R:R:Q314	R:R:Y299	7.89	Yes	Yes	1	4	4
196	R:R:S317	R:R:Y299	6.36	No	Yes	0	5	4
197	R:R:W318	R:R:Y299	14.47	Yes	Yes	1	5	4
198	R:R:C321	R:R:Y299	4.03	No	Yes	0	6	4
199	R:R:V300	R:R:W318	4.9	No	Yes	0	5	5
200	R:R:K303	R:R:Q314	6.78	No	Yes	1	4	4
201	R:R:K303	R:R:W318	24.37	No	Yes	1	4	5
202	R:R:I308	R:R:Q314	4.12	Yes	Yes	1	1	4
203	R:R:F313	R:R:S317	6.61	No	No	0	2	5
204	R:R:H319	R:R:W318	5.29	Yes	Yes	1	4	5
205	R:R:I322	R:R:W318	10.57	Yes	Yes	1	5	5
206	L:L:?1	R:R:H319	5.62	Yes	Yes	1	0	4
207	R:R:F320	R:R:L324	7.31	No	No	0	5	7
208	L:L:?1	R:R:I322	11.6	Yes	Yes	1	0	5
209	L:L:?1	R:R:Y326	16.85	Yes	No	1	0	7
210	R:R:C330	R:R:T327	5.07	No	No	0	7	5
211	R:R:N328	R:R:N332	9.54	Yes	Yes	0	9	9
212	R:R:N332	R:R:Y336	4.65	Yes	Yes	3	9	9
213	R:R:F338	R:R:V334	6.55	No	No	0	6	6
214	R:R:A337	R:R:F343	5.55	No	Yes	0	7	9
215	R:R:K344	R:R:L339	4.23	No	No	0	8	6
216	R:R:D340	R:R:N342	9.42	No	No	0	8	6
217	R:R:D340	R:R:F343	10.75	No	Yes	0	8	9
218	R:R:E341	R:R:K344	6.75	No	No	0	4	8
219	R:R:N342	R:R:R345	8.44	No	No	0	6	4
220	R:R:F350	R:R:I352	10.05	No	No	0	5	2
221	R:R:A68	R:R:Y128	4	No	No	0	4	5
222	R:R:N127	R:R:Q124	3.96	No	No	0	6	6
223	R:R:C330	R:R:G82	3.92	No	No	0	7	8
224	R:R:E310	R:R:Q314	3.82	No	Yes	0	1	4
225	R:R:I278	R:R:R277	3.76	No	No	0	7	7
226	R:R:F347	R:R:L88	3.65	No	No	0	6	6
227	R:R:F350	R:R:L88	3.65	No	No	0	5	6
228	R:R:F156	R:R:L194	3.65	No	No	0	6	4
229	R:R:T208	R:R:W133	3.64	No	Yes	0	5	8
230	R:R:D216	R:R:R211	3.57	No	No	0	4	3
231	R:R:L231	R:R:Y227	3.52	No	Yes	0	4	3
232	R:R:P181	R:R:T180	3.5	No	No	0	1	7
233	R:R:G267	R:R:K271	3.49	No	No	0	3	4
234	R:R:A113	R:R:S154	3.42	No	No	0	8	9
235	R:R:C251	R:R:V163	3.42	No	No	0	7	6
236	R:R:I308	R:R:P309	3.39	Yes	No	0	1	3
237	R:R:C346	R:R:T97	3.38	No	Yes	0	5	6
238	R:R:C217	R:R:I144	3.27	No	No	0	9	5
239	R:R:A304	R:R:K233	3.21	No	Yes	0	4	4
240	R:R:S214	R:R:T132	3.2	No	No	0	2	5
241	R:R:C235	R:R:L231	3.17	No	No	0	3	4
242	R:R:C292	R:R:L324	3.17	No	No	0	8	7
243	R:R:T101	R:R:T103	3.14	No	No	0	8	8
244	R:R:I77	R:R:V81	3.07	No	No	0	5	5
245	R:R:I167	R:R:V163	3.07	No	No	0	5	6
246	R:R:I248	R:R:V286	3.07	No	No	0	8	8
247	R:R:I215	R:R:T132	3.04	No	No	0	4	5
248	R:R:I215	R:R:T208	3.04	No	No	0	4	5
249	R:R:I298	R:R:T294	3.04	No	Yes	0	6	5
250	R:R:F221	R:R:W228	3.01	Yes	No	0	5	3
251	R:R:K141	R:R:T207	3	No	No	0	6	5
252	R:R:L254	R:R:V250	2.98	No	No	0	4	4
253	R:R:L283	R:R:T279	2.95	No	No	0	4	6
254	R:R:I234	R:R:I238	2.94	No	No	0	4	4
255	R:R:I298	R:R:I302	2.94	No	No	0	6	5
256	R:R:I302	R:R:I306	2.94	No	No	1	5	3
257	R:R:I302	R:R:I308	2.94	No	Yes	1	5	1
258	R:R:I306	R:R:I308	2.94	No	Yes	1	3	1
259	R:R:G199	R:R:Y149	2.9	No	No	0	7	4
260	R:R:K100	R:R:K98	2.87	No	No	0	6	5
261	R:R:I278	R:R:L259	2.85	No	No	5	7	8
262	R:R:I278	R:R:L265	2.85	No	Yes	5	7	3
263	R:R:I301	R:R:L305	2.85	No	No	0	6	5
264	R:R:G136	R:R:W133	2.81	No	Yes	0	7	8
265	R:R:K233	R:R:N230	2.8	Yes	No	0	4	3
266	R:R:A115	R:R:F87	2.77	No	No	0	7	4
267	R:R:A175	R:R:R179	2.77	No	No	0	6	6
268	R:R:H319	R:R:T315	2.74	Yes	No	0	4	4
269	R:R:A323	R:R:Y75	2.67	No	Yes	0	4	7
270	R:R:R258	R:R:S261	2.64	No	No	0	5	4
271	R:R:H171	R:R:K174	2.62	No	No	0	6	4
272	R:R:F221	R:R:T225	2.59	Yes	No	0	5	3
273	R:R:S125	R:R:Y75	2.54	No	Yes	0	6	7
274	R:R:I186	R:R:R182	2.51	No	No	0	3	3
275	R:R:K269	R:R:R273	2.48	No	No	0	1	4
276	R:R:S222	R:R:W228	2.47	No	No	0	6	3
277	R:R:D177	R:R:F178	2.39	No	No	0	4	4
278	R:R:G199	R:R:S145	1.86	No	No	0	7	6
279	R:R:G267	R:R:S266	1.86	No	No	0	3	5
280	R:R:A102	R:R:A184	1.79	No	No	0	6	7
281	R:R:A117	R:R:S154	1.71	No	No	0	7	9
282	R:R:A117	R:R:S329	1.71	No	No	0	7	9
283	R:R:I105	R:R:P181	1.69	Yes	No	0	6	1
284	R:R:M205	R:R:P201	1.68	No	No	0	4	7
285	R:R:C190	R:R:I186	1.64	No	No	0	4	3
286	R:R:L200	R:R:P201	1.64	No	No	0	3	7
287	R:R:S125	R:R:S76	1.63	No	No	0	6	4
288	R:R:S119	R:R:T120	1.6	No	No	0	5	6
289	R:R:V284	R:R:V288	1.6	No	Yes	0	6	6
290	R:R:T249	R:R:V245	1.59	No	No	0	4	6
291	R:R:T249	R:R:V286	1.59	No	No	0	4	8
292	R:R:A197	R:R:L194	1.58	No	No	0	4	4
293	R:R:I193	R:R:V189	1.54	No	No	0	4	4
294	R:R:H171	R:R:P172	1.53	No	No	0	6	7
295	R:R:K269	R:R:S268	1.53	No	No	0	1	4
296	R:R:M99	R:R:V94	1.52	No	No	0	7	3
297	R:R:F84	R:R:G85	1.51	No	No	0	4	7
298	R:R:L275	R:R:S266	1.5	No	No	0	6	5
299	R:R:L67	R:R:T312	1.47	No	No	0	3	4
300	R:R:I138	R:R:I142	1.47	No	No	0	2	5
301	R:R:I142	R:R:I146	1.47	No	No	0	5	5
302	R:R:D272	R:R:S266	1.47	No	No	0	3	5
303	R:R:I69	R:R:L129	1.43	No	No	0	4	5
304	R:R:I242	R:R:L246	1.43	No	No	0	5	3
305	R:R:I186	R:R:N183	1.42	No	No	0	3	4
306	R:R:Q314	R:R:T311	1.42	Yes	No	0	4	1
307	R:R:K260	R:R:L257	1.41	No	No	0	4	2
308	R:R:L254	R:R:L257	1.38	No	No	0	4	2
309	R:R:D177	R:R:L176	1.36	No	No	0	4	5
310	R:R:F178	R:R:K174	1.24	No	No	0	4	4
311	R:R:K271	R:R:R263	1.24	No	No	0	4	4
312	R:R:K344	R:R:R348	1.24	No	No	0	8	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y75	7.644	5	1	7
2	R:R:I93	5.3725	4	2	7
3	R:R:T97	7.745	4	2	6
4	R:R:I105	3.7925	4	0	6
5	R:R:Y106	8.065	6	0	7
6	R:R:L110	7.87	5	3	9
7	R:R:D114	9.426	5	3	9
8	R:R:W133	10.2171	7	6	8
9	R:R:F135	11.568	5	0	7
10	R:R:F152	7.8375	4	0	7
11	R:R:T153	10.885	4	4	7
12	R:R:Y166	8.5975	4	0	8
13	R:R:N191	7.1925	4	4	7
14	R:R:W192	11.178	5	4	9
15	R:R:K209	7.245	4	8	3
16	R:R:F221	7.31	5	0	5
17	R:R:Y227	8.1925	4	9	3
18	R:R:K233	3.99	4	0	4
19	R:R:Y252	10.05	4	0	9
20	R:R:L265	5.652	5	5	3
21	R:R:V288	4.86	4	0	6
22	R:R:W293	8.48667	6	7	8
23	R:R:T294	6.51	4	0	5
24	R:R:H297	9.2425	4	0	8
25	R:R:Y299	8.222	5	1	4
26	R:R:I308	3.3475	4	1	1
27	R:R:Q314	4.806	5	1	4
28	R:R:W318	10.7167	6	1	5
29	R:R:H319	9.10167	6	1	4
30	R:R:I322	9.4325	4	1	5
31	R:R:N328	7.8325	4	0	9
32	R:R:N332	9.93	5	3	9
33	R:R:Y336	6.84	6	3	9
34	R:R:F343	8.195	6	2	9
35	L:L:?1	13.5833	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I322	R:R:W318	16.8536	10.57	Yes	Yes	1	5	5
2	R:R:H319	R:R:W318	17.9978	5.29	Yes	Yes	1	4	5
3	L:L:?1	R:R:I322	16.9915	11.6	Yes	Yes	1	0	5
4	L:L:?1	R:R:H319	23.8567	5.62	Yes	Yes	1	0	4
5	L:L:?1	R:R:Y326	17.7369	16.85	Yes	No	1	0	7
6	R:R:L121	R:R:Y326	16.6636	17.58	No	No	0	7	7
7	R:R:L121	R:R:T118	12.9291	4.42	No	No	0	7	6
8	R:R:D114	R:R:N332	11.1476	12.12	Yes	Yes	3	9	9
9	R:R:N328	R:R:N332	77.731	9.54	Yes	Yes	0	9	9
10	R:R:N328	R:R:W293	79.5349	7.91	Yes	Yes	0	9	8
11	R:R:H297	R:R:W293	93.1162	9.52	Yes	Yes	0	8	8
12	L:L:?1	R:R:H297	100	4.82	Yes	Yes	0	0	8
13	R:R:F338	R:R:V89	13.4695	5.24	No	No	0	6	9
14	R:R:A337	R:R:V89	14.6584	5.09	No	No	0	7	9
15	R:R:A337	R:R:F343	15.8399	5.55	No	Yes	0	7	9
16	R:R:F343	R:R:I107	28.6348	6.28	Yes	No	0	9	8
17	R:R:I107	R:R:M161	29.6784	4.37	No	No	0	8	8
18	R:R:M161	R:R:Y336	51.1982	7.18	No	Yes	0	8	9
19	R:R:N332	R:R:Y336	59.7704	4.65	Yes	Yes	3	9	9
20	R:R:F338	R:R:L88	11.0693	4.87	No	No	0	6	6
21	R:R:M151	R:R:W293	16.6822	6.98	No	Yes	0	7	8
22	R:R:F152	R:R:M151	14.8709	4.98	Yes	No	0	7	7
23	R:R:F152	R:R:F156	13.4509	9.65	Yes	No	0	7	6
24	R:R:F156	R:R:N191	12.9701	9.67	No	Yes	0	6	7
25	R:R:N191	R:R:T153	10.663	10.24	Yes	Yes	4	7	7
26	R:R:L110	R:R:N332	13.7378	12.36	Yes	Yes	3	9	9
27	R:R:L110	R:R:T157	21.5609	5.9	Yes	No	0	9	7
28	R:R:N109	R:R:T157	17.2226	11.7	No	No	0	9	7
29	R:R:N109	R:R:W192	10.786	14.69	No	Yes	0	9	9
30	R:R:A184	R:R:Y106	10.2978	6.67	No	Yes	0	7	7
31	R:R:M161	R:R:Y106	26.1414	5.99	No	Yes	0	8	7
32	R:R:I105	R:R:N188	14.5019	4.25	Yes	No	0	6	7
33	R:R:N127	R:R:W133	34.1284	13.56	No	Yes	0	6	8
34	R:R:N127	R:R:Q124	35.2465	3.96	No	No	0	6	6
35	L:L:?1	R:R:Q124	36.2417	24.95	Yes	No	0	0	6
36	R:R:T208	R:R:W133	16.3505	3.64	No	Yes	0	5	8
37	R:R:I215	R:R:T208	13.8906	3.04	No	No	0	4	5
38	R:R:I215	R:R:T132	11.4308	3.04	No	No	0	4	5
39	L:L:?1	R:R:Y148	22.2877	12.45	Yes	No	0	0	4
40	R:R:I248	R:R:V286	14.8671	3.07	No	No	0	8	8
41	R:R:T249	R:R:V286	14.9007	1.59	No	No	0	4	8
42	R:R:T249	R:R:V245	15.2212	1.59	No	No	0	4	6
43	R:R:F241	R:R:V245	14.7367	5.24	No	No	0	8	6
44	R:R:F241	R:R:H297	19.4775	18.1	No	Yes	0	8	8
45	R:R:I248	R:R:S162	15.7653	7.74	No	No	0	8	9
46	R:R:C251	R:R:S162	20.2341	5.16	No	No	0	7	9
47	R:R:C251	R:R:Y166	16.8015	8.06	No	Yes	0	7	8
48	R:R:R165	R:R:Y336	42.6745	5.14	No	Yes	0	9	9
49	R:R:R165	R:R:Y252	41.9105	11.32	No	Yes	0	9	9
50	R:R:M255	R:R:Y252	31.6388	4.79	No	Yes	0	8	9
51	R:R:M255	R:R:V169	30.502	7.61	No	No	0	8	8
52	R:R:L259	R:R:V169	29.3765	4.47	No	No	0	8	8
53	R:R:I105	R:R:P181	16.7679	1.69	Yes	No	0	6	1
54	R:R:P181	R:R:T180	13.9913	3.5	No	No	0	1	7
55	R:R:N183	R:R:T180	11.2072	8.77	No	No	0	4	7
56	R:R:V300	R:R:W318	16.4101	4.9	No	Yes	0	5	5
57	R:R:K233	R:R:V300	13.5962	4.55	Yes	No	0	4	5
58	R:R:V202	R:R:Y148	20.0924	15.14	No	No	0	5	4
59	R:R:L219	R:R:V202	19.075	5.96	No	No	0	5	5
60	R:R:F221	R:R:L219	18.0202	7.31	Yes	No	0	5	5
61	R:R:S214	R:R:T132	10.432	3.2	No	No	0	2	5
62	R:R:F221	R:R:W228	12.6645	3.01	Yes	No	0	5	3
63	R:R:L259	R:R:L265	18.5569	5.54	No	Yes	5	8	3
64	R:R:L265	R:R:L275	15.3367	6.92	Yes	No	0	3	6
65	R:R:L275	R:R:S266	14.0994	1.5	No	No	0	6	5
66	R:R:G267	R:R:S266	11.6023	1.86	No	No	0	3	5
67	R:R:G267	R:R:K271	10.3425	3.49	No	No	0	3	4
68	L:L:?1	R:R:I296	17.0437	8.92	Yes	No	1	0	6
69	R:R:W318	R:R:Y299	21.9932	14.47	Yes	Yes	1	5	4
70	R:R:Q314	R:R:Y299	10.5028	7.89	Yes	Yes	1	4	4
71	R:R:K303	R:R:W318	13.1676	24.37	No	Yes	1	4	5
72	R:R:K303	R:R:Q314	10.4767	6.78	No	Yes	1	4	4
73	R:R:I296	R:R:W318	16.1567	4.7	No	Yes	1	6	5
74	R:R:L110	R:R:Y336	10.7972	4.69	Yes	Yes	3	9	9
75	R:R:S162	R:R:Y252	15.9554	15.26	No	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I71	R:R:Y128	20.55	1	No	No	4	5	2	2
R:R:H319	R:R:I71	15.91	1	Yes	No	4	4	1	2
R:R:H319	R:R:Y75	10.89	1	Yes	Yes	4	7	1	1
R:R:I322	R:R:Y75	9.67	1	Yes	Yes	5	7	1	1
L:L:?1	R:R:Y75	12.45	1	Yes	Yes	0	7	0	1
R:R:D147	R:R:T120	7.23	1	No	No	6	6	1	2
R:R:L121	R:R:Y326	17.58	0	No	No	7	7	2	1
L:L:?1	R:R:Q124	24.95	1	Yes	No	0	6	0	1
R:R:H319	R:R:Y128	14.16	1	Yes	No	4	5	1	2
R:R:D147	R:R:Y326	11.49	1	No	No	6	7	1	1
L:L:?1	R:R:D147	24.59	1	Yes	No	0	6	0	1
R:R:V202	R:R:Y148	15.14	0	No	No	5	4	2	1
R:R:L232	R:R:Y148	7.03	0	No	No	5	4	2	1
L:L:?1	R:R:Y148	12.45	1	Yes	No	0	4	0	1
R:R:F237	R:R:H297	4.53	0	No	Yes	5	8	2	1
R:R:F241	R:R:H297	18.1	0	No	Yes	8	8	2	1
R:R:H297	R:R:W293	9.52	0	Yes	Yes	8	8	1	2
R:R:I296	R:R:W318	4.7	1	No	Yes	6	5	1	2
R:R:I296	R:R:I322	5.89	1	No	Yes	6	5	1	1
L:L:?1	R:R:I296	8.92	1	Yes	No	0	6	0	1
L:L:?1	R:R:H297	4.82	1	Yes	Yes	0	8	0	1
R:R:H319	R:R:W318	5.29	1	Yes	Yes	4	5	1	2
R:R:I322	R:R:W318	10.57	1	Yes	Yes	5	5	1	2
L:L:?1	R:R:H319	5.62	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:I322	11.6	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y326	16.85	1	Yes	No	0	7	0	1
R:R:N127	R:R:Q124	3.96	0	No	No	6	6	2	1
R:R:H319	R:R:T315	2.74	1	Yes	No	4	4	1	2
R:R:A323	R:R:Y75	2.67	0	No	Yes	4	7	2	1
R:R:S125	R:R:Y75	2.54	0	No	Yes	6	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7T2G_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.02
Number of Linked Nodes	274
Number of Links	312
Number of Hubs	35
Number of Links mediated by Hubs	144
Number of Communities	9
Number of Nodes involved in Communities	49
Number of Links involved in Communities	65

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	54745
Length Of Smallest Path	3
Average Path Length	12.755
Length of Longest Path	33
Minimum Path Strength	1.395
Average Path Strength	7.71277
Maximum Path Strength	24.77
Minimum Path Correlation	0.7
Average Path Correlation	0.925745
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	51.947
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.0588
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled opioid receptor activity • protein binding • G-protein alpha-subunit binding • peptide receptor activity • beta-endorphin receptor activity • G protein-coupled peptide receptor activity • melanocortin receptor activity • neuropeptide receptor activity • morphine receptor activity • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • behavior • multicellular organismal process • locomotory behavior • cellular response to stimulus • cellular response to nitrogen compound • regulation of cellular process • response to stimulus • signaling • cell communication • synaptic signaling • signal transduction • cellular response to acetylcholine • regulation of biological process • biological regulation • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to acetylcholine • G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • trans-synaptic signaling • regulation of signaling • modulation of chemical synaptic transmission • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of cellular process • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • regulation of localization • transport • regulation of signaling receptor activity • regulation of transmembrane transporter activity • localization • regulation of NMDA receptor activity • regulation of transport • establishment of localization • transmembrane transport • regulation of molecular function • regulation of transmembrane transport • regulation of neurotransmitter receptor activity • G protein-coupled opioid receptor signaling pathway • regulation of biosynthetic process • regulation of nitric oxide biosynthetic process • negative regulation of metabolic process • negative regulation of biological process • reactive nitrogen species metabolic process • nitric oxide metabolic process • nitric oxide biosynthetic process • biosynthetic process • negative regulation of nitric oxide biosynthetic process • negative regulation of biosynthetic process • negative regulation of cellular process • regulation of nitric oxide metabolic process • regulation of metabolic process • system process • nervous system process • transmission of nerve impulse • phospholipase C-activating G protein-coupled receptor signaling pathway • regulation of biological quality • negative regulation of cytosolic calcium ion concentration • positive regulation of nervous system development • regulation of developmental process • cellular developmental process • cell development • regulation of cell differentiation • regulation of neurogenesis • regulation of cell development • regulation of nervous system development • positive regulation of developmental process • multicellular organism development • neurogenesis • positive regulation of cell differentiation • cell differentiation • anatomical structure development • positive regulation of neurogenesis • regulation of multicellular organismal process • system development • developmental process • regulation of multicellular organismal development • positive regulation of cell development • nervous system development • positive regulation of multicellular organismal process • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • sensory perception • sensory perception of pain • negative regulation of protein transport • establishment of protein localization • nitrogen compound transport • regulation of protein localization • negative regulation of signaling • negative regulation of Wnt protein secretion • negative regulation of transport • negative regulation of cell communication • protein localization to extracellular region • secretion by cell • regulation of secretion by cell • negative regulation of secretion • signal release • negative regulation of secretion by cell • intracellular protein localization • regulation of Wnt protein secretion • negative regulation of protein localization • secretion • establishment of protein localization to extracellular region • regulation of establishment of protein localization • export from cell • negative regulation of establishment of protein localization • regulation of protein transport • Wnt protein secretion • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • protein transport • macromolecule localization • periplasmic space • somatodendritic compartment • cell body • perikaryon • neuronal cell body • presynapse • synapse • cell junction • dendrite • dendritic tree • neuron projection • GABA-ergic synapse • endosome • intracellular vesicle • cytoplasmic vesicle • axon • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	EIG
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	EIG
Name	Mitragynine pseudoindoxyl
Synonyms	methyl (2E)-4-[(2S,2'S)-1'-butyl-4-methoxy-3-oxo-1,3-dihydrospiro[indole-2,3'-pyrrolidin]-2'-yl]-2-(methoxymethylidene)butanoate
Identifier
Formula	C23 H30 N2 O5
Molecular Weight	414.495
SMILES
PubChem	44301701
Formal Charge	0
Total Atoms	60
Total Chiral Atoms	4
Total Bonds	63
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P42866
Sequence	>7T2G_nogp_Chain_R L A L A I A I T A L Y S I V C V V G L F G N F L V M Y V I V R Y T K M K T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G T W P F G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H P V K A L D F R T P R N A K I V N V C N W I L S S A I G L P V M F M A T T K Y R Q G S I D C T L T F S H P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V R M L S G S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T I P E T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F K R C F R E F C I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9BJK	A	Peptide	Opioid	μ	Mus musculus	Naloxone	NAM	-	3.26	2024-07-17	doi.org/10.1038/s41586-024-07587-7
	8K9L	A	Peptide	Opioid	μ	Homo sapiens	Damgo	BMS-986122	Gi3/β1/γ1	3.05	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9L (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Damgo	BMS-986122		3.05	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	7SBF	A	Peptide	Opioid	μ	Mus musculus	PZM21	-	Gi1/β1/γ2	2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SBF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	PZM21	-		2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG	A	Peptide	Opioid	μ	Mus musculus	FH210	-	Gi1/β1/γ2	3	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	FH210	-		3	2022-04-20	doi.org/10.1002/anie.202200269
	8EF5	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-	Gi1/β1/γ2	3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF5 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-		3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF6	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF6 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFB	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFB (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFL	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFL (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-	Gi1/β1/γ2	2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-		2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFQ	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-	Gi1/β1/γ2	3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFQ (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-		3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8F7Q	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-	Gi1/β1/γ2	3.22	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7Q (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-		3.22	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7R	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	Gi1/β1/γ2	3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7R (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	9BQJ	A	Peptide	Opioid	μ	Mus musculus	RO76	-	Gi1/β1/γ2	3.3	2024-09-11	doi.org/10.1021/acscentsci.4c00525
	9BQJ (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	RO76	-		3.3	2024-09-11	doi.org/10.1021/acscentsci.4c00525
	4DKL	A	Peptide	Opioid	μ	Mus musculus	β-Funaltrexamine	-	-	2.8	2012-03-21	doi.org/10.1038/nature10954
	5C1M	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.07	2015-08-05	doi.org/10.1038/nature14886
	8K9K	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-	Gi3/β1/γ1	2.98	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9K (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-		2.98	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	6DDE	A	Peptide	Opioid	μ	Mus musculus	Damgo	-	Gi1/β1/γ2	3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDE (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Damgo	-		3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDF	A	Peptide	Opioid	μ	Mus musculus	Damgo	-	Gi1/β1/γ2	3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Damgo	-		3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	7U2L	A	Peptide	Opioid	μ	Mus musculus	PubChem 163201242	-	Gi1/β1/γ2	3.2	2022-05-04	doi.org/10.1038/s41586-022-05588-y
	7U2L (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	PubChem 163201242	-		3.2	2022-05-04	doi.org/10.1038/s41586-022-05588-y
	7U2K	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-	Gi1/β1/γ2	3.3	2022-12-07	doi.org/10.1038/s41586-022-05588-y
	7U2K (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-		3.3	2022-12-07	doi.org/10.1038/s41586-022-05588-y
	7T2G	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-	Gi1/β1/γ2	2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2G (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-		2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2H	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-	Gi1/β1/γ2	2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2H (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-		2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7UL4	A	Peptide	Opioid	μ	Mus musculus	Alvimopan	-	-	2.8	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	8QOT	A	Peptide	Opioid	μ	Mus musculus	Nanobody-E	-	-	3.2	2023-12-27	doi.org/10.1101/2023.12.06.570395
	9MQH	A	Peptide	Opioid	μ	Homo sapiens	-	-	-	3.9	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQI	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.3	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQJ	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.23	2025-02-12	doi.org/10.1101/2025.01.09.632033
	8E0G	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.1	2023-10-18	doi.org/10.1186/s12915-023-01689-w
	8Y73	A	Peptide	Opioid	μ	Homo sapiens	Peptide	MPAM-15	Gi1/β1/γ2	2.84	2025-08-06	To be published
	8Y73 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Peptide	MPAM-15		2.84	2025-08-06	To be published
	8Y72	A	Peptide	Opioid	μ	Homo sapiens	Peptide	BMS-986122	Gi1/β1/γ2	2.65	2025-08-06	To be published
	8Y72 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Peptide	BMS-986122		2.65	2025-08-06	To be published

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