psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T314	R:R:T69	3.14	No	No	0	1	4
2	R:R:I73	R:R:Y130	9.67	No	No	4	6	5
3	R:R:H321	R:R:I73	7.95	Yes	No	4	4	6
4	R:R:M74	R:R:S127	3.07	No	No	0	5	6
5	R:R:L131	R:R:M74	9.9	No	No	0	4	5
6	R:R:F322	R:R:L76	4.87	No	No	0	4	5
7	R:R:A325	R:R:L76	3.15	No	No	0	6	5
8	R:R:L123	R:R:Y77	3.52	Yes	No	0	7	7
9	R:R:S127	R:R:Y77	6.36	No	No	0	6	7
10	R:R:H321	R:R:Y77	13.07	Yes	No	0	4	7
11	R:R:C81	R:R:L85	3.17	Yes	No	5	6	6
12	R:R:C81	R:R:T120	3.38	Yes	No	5	6	5
13	R:R:C81	R:R:L123	4.76	Yes	Yes	0	6	7
14	R:R:C81	R:R:P124	3.77	Yes	No	0	6	8
15	R:R:C332	R:R:V83	3.42	No	No	0	8	5
16	R:R:C332	R:R:G84	3.92	No	No	0	8	8
17	R:R:F89	R:R:L85	3.65	No	No	0	4	6
18	R:R:L85	R:R:T120	5.9	No	No	5	6	5
19	R:R:D116	R:R:N88	6.73	Yes	No	0	9	9
20	R:R:A117	R:R:N88	4.69	No	No	0	7	9
21	R:R:N88	R:R:P335	4.89	No	No	0	9	9
22	R:R:F89	R:R:M92	3.73	No	No	0	4	7
23	R:R:I95	R:R:V91	3.07	No	Yes	0	7	9
24	R:R:A113	R:R:V91	3.39	No	Yes	0	9	9
25	R:R:P335	R:R:V91	3.53	No	Yes	0	9	9
26	R:R:A339	R:R:V91	3.39	No	Yes	0	6	9
27	R:R:F110	R:R:M92	6.22	Yes	No	0	6	7
28	R:R:R97	R:R:Y93	10.29	No	No	0	5	4
29	R:R:F349	R:R:V94	3.93	No	No	0	6	7
30	R:R:F110	R:R:I95	7.54	Yes	No	0	6	7
31	R:R:F345	R:R:I95	5.02	Yes	No	0	8	7
32	R:R:R97	R:R:Y98	4.12	No	No	0	5	4
33	R:R:F352	R:R:Y98	18.57	No	No	0	7	4
34	R:R:N106	R:R:T99	5.85	No	No	0	8	6
35	R:R:F110	R:R:M101	4.98	Yes	No	0	6	7
36	R:R:N106	R:R:T103	4.39	No	No	0	8	7
37	R:R:R181	R:R:T105	6.47	Yes	No	0	7	8
38	R:R:F345	R:R:N106	7.25	Yes	No	0	8	8
39	R:R:T162	R:R:Y108	6.24	No	Yes	0	7	7
40	R:R:M163	R:R:Y108	5.99	No	Yes	0	9	7
41	R:R:D166	R:R:Y108	5.75	No	Yes	0	8	7
42	R:R:A186	R:R:Y108	4	No	Yes	0	7	7
43	R:R:N190	R:R:Y108	10.47	No	Yes	0	7	7
44	R:R:F345	R:R:I109	6.28	Yes	No	0	8	8
45	R:R:N111	R:R:N190	6.81	No	No	0	9	7
46	R:R:N111	R:R:W194	4.52	No	No	0	9	9
47	R:R:L112	R:R:T159	5.9	No	No	0	9	8
48	R:R:L112	R:R:L160	5.54	No	No	0	9	8
49	R:R:L114	R:R:L118	4.15	No	No	0	7	7
50	R:R:A115	R:R:T155	3.36	No	Yes	0	8	7
51	R:R:D116	R:R:S156	7.36	Yes	No	0	9	9
52	R:R:D116	R:R:S331	10.31	Yes	No	0	9	9
53	R:R:D116	R:R:N334	8.08	Yes	No	0	9	9
54	R:R:L118	R:R:N152	10.98	No	No	0	7	8
55	R:R:A119	R:R:N152	3.13	No	No	0	7	8
56	R:R:T122	R:R:V145	4.76	Yes	No	0	6	5
57	R:R:I148	R:R:T122	3.04	No	Yes	0	5	6
58	R:R:D149	R:R:T122	4.34	Yes	Yes	0	5	6
59	R:R:L123	R:R:Y328	4.69	Yes	Yes	0	7	7
60	R:R:F125	R:R:F137	4.29	No	Yes	0	6	6
61	R:R:F125	R:R:V145	6.55	No	No	0	6	5
62	R:R:D149	R:R:Q126	7.83	Yes	No	1	5	6
63	R:R:Q126	R:R:Y328	6.76	No	Yes	1	6	7
64	L:L:?1	R:R:Q126	11.19	Yes	No	1	0	6
65	R:R:F137	R:R:V128	6.55	Yes	No	0	6	3
66	R:R:N129	R:R:W135	9.04	No	Yes	0	4	8
67	R:R:T317	R:R:Y130	3.75	No	No	0	4	5
68	R:R:H321	R:R:Y130	11.98	Yes	No	4	4	5
69	R:R:S216	R:R:T134	3.2	No	No	0	1	5
70	R:R:I217	R:R:T134	3.04	No	No	0	4	5
71	R:R:F137	R:R:W135	23.05	Yes	Yes	0	6	8
72	R:R:C142	R:R:W135	5.22	No	Yes	6	9	8
73	R:R:V145	R:R:W135	6.13	No	Yes	0	5	8
74	R:R:C219	R:R:W135	18.28	No	Yes	6	9	8
75	R:R:F137	R:R:P136	4.33	Yes	No	0	6	3
76	R:R:F137	R:R:L141	6.09	Yes	No	0	6	5
77	R:R:T139	R:R:T210	7.85	No	No	0	3	4
78	R:R:C142	R:R:T210	3.38	No	No	0	9	4
79	R:R:C142	R:R:C219	7.28	No	No	6	9	9
80	R:R:A208	R:R:I146	3.25	No	No	0	5	4
81	R:R:C219	R:R:I146	3.27	No	No	0	9	4
82	R:R:M205	R:R:S147	7.67	No	No	0	5	6
83	R:R:I148	R:R:N152	4.25	No	No	0	5	8
84	R:R:D149	R:R:Y328	8.05	Yes	Yes	1	5	7
85	L:L:?1	R:R:D149	11.41	Yes	Yes	1	0	5
86	R:R:V204	R:R:Y150	3.79	No	No	0	5	4
87	R:R:L221	R:R:Y150	3.52	No	No	0	4	4
88	L:L:?1	R:R:Y150	6.07	Yes	No	0	0	4
89	R:R:T155	R:R:Y151	7.49	Yes	Yes	3	7	5
90	R:R:W194	R:R:Y151	10.61	No	Yes	3	9	5
91	R:R:S197	R:R:Y151	3.82	No	Yes	3	8	5
92	R:R:F154	R:R:M153	3.73	Yes	No	0	6	7
93	R:R:M153	R:R:W295	4.65	No	Yes	1	7	8
94	L:L:?1	R:R:M153	9.14	Yes	No	1	0	7
95	R:R:F154	R:R:F158	5.36	Yes	No	0	6	5
96	R:R:F154	R:R:I200	6.28	Yes	No	0	6	5
97	R:R:T155	R:R:W194	14.55	Yes	No	3	7	9
98	R:R:S197	R:R:T155	6.4	No	Yes	3	8	7
99	R:R:I157	R:R:P246	3.39	No	No	0	7	8
100	R:R:F291	R:R:I157	7.54	Yes	No	1	9	7
101	R:R:I157	R:R:W295	7.05	No	Yes	1	7	8
102	R:R:L160	R:R:Y338	8.21	No	Yes	0	8	9
103	R:R:C161	R:R:P246	3.77	No	No	0	7	8
104	R:R:C161	R:R:I249	4.91	No	No	0	7	6
105	R:R:N193	R:R:T162	7.31	No	No	0	7	7
106	R:R:I250	R:R:S164	4.64	No	No	1	8	9
107	R:R:C253	R:R:S164	5.16	No	No	0	8	9
108	R:R:S164	R:R:Y254	10.17	No	Yes	1	9	9
109	R:R:I169	R:R:V165	3.07	No	No	0	5	6
110	R:R:D166	R:R:F180	5.97	No	Yes	0	8	3
111	R:R:D166	R:R:R181	16.68	No	Yes	0	8	7
112	R:R:R167	R:R:Y254	8.23	No	Yes	0	9	9
113	R:R:R167	R:R:Y338	6.17	No	Yes	0	9	9
114	R:R:C172	R:R:Y168	8.06	No	Yes	0	7	8
115	R:R:H173	R:R:Y168	4.36	No	Yes	0	6	8
116	R:R:C253	R:R:Y168	6.72	No	Yes	0	8	8
117	R:R:L256	R:R:Y168	7.03	No	Yes	0	5	8
118	R:R:F180	R:R:I169	12.56	Yes	No	0	3	5
119	R:R:M257	R:R:V171	7.61	No	No	2	8	8
120	R:R:L261	R:R:V171	4.47	Yes	No	2	8	8
121	R:R:C172	R:R:R260	4.18	No	No	0	7	5
122	R:R:F180	R:R:N185	4.83	Yes	Yes	7	3	4
123	R:R:F180	R:R:I189	3.77	Yes	No	7	3	5
124	R:R:I189	R:R:N185	7.08	No	Yes	7	5	4
125	R:R:I195	R:R:V191	3.07	No	No	0	4	4
126	R:R:L202	R:R:S198	6.01	No	No	0	4	4
127	R:R:F223	R:R:M207	4.98	Yes	No	0	6	5
128	R:R:T209	R:R:T222	6.28	No	No	0	5	4
129	R:R:I217	R:R:T210	3.04	No	No	0	4	4
130	R:R:K211	R:R:T222	10.51	No	No	0	1	4
131	R:R:I217	R:R:Y212	3.63	No	No	0	4	3
132	R:R:D218	R:R:T220	7.23	No	No	0	4	4
133	R:R:F223	R:R:L221	3.65	Yes	No	0	6	4
134	R:R:E231	R:R:F223	9.33	No	Yes	0	4	6
135	R:R:F223	R:R:L234	4.87	Yes	No	0	6	6
136	R:R:S224	R:R:W230	4.94	No	No	0	3	1
137	R:R:H225	R:R:P226	4.58	No	No	0	2	4
138	R:R:P226	R:R:W228	5.4	No	No	0	4	1
139	R:R:W228	R:R:Y229	4.82	No	No	0	1	1
140	R:R:W230	R:R:Y229	12.54	No	No	0	1	1
141	R:R:L233	R:R:Y229	5.86	No	No	0	3	1
142	R:R:E231	R:R:K235	4.05	No	Yes	0	4	4
143	R:R:K235	R:R:V302	4.55	Yes	No	0	4	5
144	R:R:A306	R:R:K235	3.21	No	Yes	0	4	4
145	R:R:C237	R:R:F241	4.19	No	No	0	5	4
146	R:R:F239	R:R:I244	8.79	No	No	0	6	4
147	R:R:F239	R:R:H299	3.39	No	No	0	6	7
148	R:R:F239	R:R:I303	7.54	No	No	0	6	5
149	R:R:F241	R:R:I240	3.77	No	No	0	4	5
150	R:R:F243	R:R:I244	3.77	Yes	No	0	8	4
151	R:R:F243	R:R:T296	7.78	Yes	Yes	0	8	5
152	R:R:F243	R:R:H299	18.1	Yes	No	0	8	7
153	R:R:M245	R:R:P246	5.03	No	No	0	5	8
154	R:R:I250	R:R:Y254	3.63	No	Yes	1	8	9
155	R:R:F291	R:R:I250	5.02	Yes	No	1	9	8
156	R:R:V284	R:R:Y254	5.05	No	Yes	0	8	9
157	R:R:V287	R:R:Y254	3.79	No	Yes	1	8	9
158	R:R:V288	R:R:Y254	3.79	No	Yes	0	8	9
159	R:R:L261	R:R:M257	4.24	Yes	No	2	8	8
160	R:R:I258	R:R:V284	4.61	No	No	0	5	8
161	R:R:L261	R:R:L267	4.15	Yes	Yes	2	8	1
162	R:R:L267	R:R:L277	8.3	Yes	No	0	1	6
163	R:R:D274	R:R:G269	3.35	No	No	0	1	1
164	R:R:K273	R:R:S270	7.65	No	No	0	3	2
165	R:R:E272	R:R:R275	10.47	No	No	0	3	4
166	R:R:N276	R:R:R279	12.05	No	No	0	5	7
167	R:R:E343	R:R:R279	4.65	No	No	0	5	7
168	R:R:L341	R:R:M283	7.07	No	No	0	7	8
169	R:R:L337	R:R:V287	5.96	Yes	No	1	8	8
170	R:R:V287	R:R:Y338	7.57	No	Yes	1	8	9
171	R:R:L333	R:R:V290	4.47	No	No	0	6	7
172	R:R:L337	R:R:V290	4.47	Yes	No	0	8	7
173	R:R:F291	R:R:W295	7.02	Yes	Yes	1	9	8
174	R:R:F291	R:R:N330	4.83	Yes	Yes	1	9	9
175	R:R:I292	R:R:T296	3.04	No	Yes	0	6	5
176	R:R:C294	R:R:T329	3.38	No	No	0	9	5
177	R:R:C294	R:R:N330	7.87	No	Yes	0	9	9
178	R:R:H299	R:R:W295	8.46	No	Yes	0	7	8
179	R:R:N330	R:R:W295	7.91	Yes	Yes	1	9	8
180	L:L:?1	R:R:W295	5.16	Yes	Yes	1	0	8
181	R:R:P297	R:R:T296	3.5	No	Yes	0	9	5
182	R:R:I300	R:R:T296	3.04	No	Yes	0	6	5
183	R:R:L326	R:R:P297	4.93	No	No	0	8	9
184	R:R:C323	R:R:I298	3.27	No	No	0	6	6
185	R:R:I310	R:R:Y301	3.63	No	No	8	4	5
186	R:R:Q316	R:R:Y301	4.51	No	No	8	3	5
187	R:R:W320	R:R:Y301	5.79	Yes	No	0	4	5
188	R:R:K305	R:R:W320	10.44	No	Yes	0	3	4
189	R:R:I310	R:R:Q316	9.61	No	No	8	4	3
190	R:R:H321	R:R:W320	5.29	Yes	Yes	0	4	4
191	R:R:I324	R:R:W320	7.05	No	Yes	0	5	4
192	L:L:?1	R:R:I324	5.54	Yes	No	0	0	5
193	L:L:?1	R:R:Y328	12.89	Yes	Yes	1	0	7
194	R:R:N330	R:R:N334	8.17	Yes	No	0	9	9
195	R:R:N334	R:R:Y338	6.98	No	Yes	0	9	9
196	R:R:F340	R:R:V336	5.24	No	No	0	6	6
197	R:R:L337	R:R:Y338	3.52	Yes	Yes	1	8	9
198	R:R:F340	R:R:F349	5.36	No	No	0	6	6
199	R:R:D342	R:R:F345	5.97	No	Yes	0	8	8
200	R:R:F223	R:R:W230	3.01	Yes	No	0	6	1
201	R:R:L123	R:R:V80	2.98	Yes	No	0	7	7
202	R:R:L256	R:R:V252	2.98	No	No	0	5	4
203	R:R:L337	R:R:V286	2.98	Yes	No	0	8	6
204	R:R:L333	R:R:V336	2.98	No	No	0	6	6
205	R:R:L277	R:R:T281	2.95	No	No	0	6	6
206	R:R:I144	R:R:I148	2.94	No	No	0	5	5
207	R:R:I236	R:R:I240	2.94	No	No	0	4	5
208	R:R:I300	R:R:I304	2.94	No	No	0	6	5
209	R:R:I107	R:R:K187	2.91	No	No	0	5	2
210	R:R:G201	R:R:Y151	2.9	No	Yes	0	6	5
211	L:L:?1	R:R:V238	2.89	Yes	No	0	0	5
212	R:R:I303	R:R:L307	2.85	No	No	0	5	5
213	R:R:I107	R:R:N190	2.83	No	No	0	5	7
214	R:R:L112	R:R:M163	2.83	No	No	0	9	9
215	R:R:L202	R:R:M205	2.83	No	No	0	4	5
216	R:R:L267	R:R:M266	2.83	Yes	No	0	1	4
217	R:R:I280	R:R:N276	2.83	No	No	0	8	5
218	R:R:E312	R:R:T317	2.82	No	No	0	2	4
219	R:R:K235	R:R:N232	2.8	Yes	No	0	4	2
220	R:R:A104	R:R:R181	2.77	No	Yes	0	5	7
221	R:R:A242	R:R:F154	2.77	No	Yes	0	5	6
222	R:R:A170	R:R:R181	2.77	No	Yes	0	8	7
223	L:L:?1	R:R:I298	2.77	Yes	No	0	0	6
224	R:R:R260	R:R:S263	2.64	No	No	0	5	3
225	R:R:F110	R:R:V96	2.62	Yes	No	0	6	3
226	R:R:R260	R:R:V171	2.62	No	No	0	5	8
227	R:R:F243	R:R:V247	2.62	Yes	No	0	8	6
228	R:R:F291	R:R:V247	2.62	Yes	No	0	9	6
229	R:R:I188	R:R:R184	2.51	No	No	0	3	3
230	R:R:F340	R:R:L90	2.44	No	No	0	6	6
231	R:R:E351	R:R:F352	2.33	No	No	0	3	7
232	L:L:?1	R:R:G327	2.21	Yes	No	0	0	7
233	R:R:G201	R:R:S147	1.86	No	No	0	6	6
234	R:R:G269	R:R:S268	1.86	No	No	0	1	4
235	R:R:G84	R:R:T120	1.82	No	No	0	8	5
236	R:R:G133	R:R:M132	1.75	No	No	0	2	4
237	R:R:P183	R:R:T182	1.75	No	No	0	1	7
238	R:R:C323	R:R:S319	1.72	No	No	0	6	4
239	R:R:I310	R:R:P311	1.69	No	No	0	4	1
240	R:R:M207	R:R:P203	1.68	No	No	0	5	8
241	R:R:A177	R:R:I169	1.62	No	No	0	6	5
242	R:R:A208	R:R:K143	1.61	No	No	0	5	6
243	R:R:S121	R:R:T122	1.6	No	Yes	0	5	6
244	R:R:T69	R:R:V318	1.59	No	No	0	4	1
245	R:R:C237	R:R:L233	1.59	No	No	0	5	3
246	R:R:T251	R:R:V247	1.59	No	No	0	5	6
247	R:R:T251	R:R:V288	1.59	No	No	0	5	8
248	R:R:I73	R:R:V318	1.54	No	No	0	6	1
249	R:R:H173	R:R:P174	1.53	No	No	0	6	8
250	R:R:I68	R:R:T72	1.52	No	No	0	3	4
251	R:R:M132	R:R:V128	1.52	No	No	0	4	3
252	R:R:M266	R:R:V264	1.52	No	No	0	4	6
253	R:R:F86	R:R:G87	1.51	No	No	0	5	8
254	R:R:K102	R:R:T103	1.5	No	No	0	7	7
255	R:R:L307	R:R:V308	1.49	No	No	0	5	2
256	R:R:I140	R:R:I144	1.47	No	No	0	1	5
257	R:R:I71	R:R:M67	1.46	No	No	0	5	2
258	R:R:N185	R:R:T182	1.46	Yes	No	0	4	7
259	R:R:I258	R:R:K262	1.45	No	No	0	5	4
260	R:R:K100	R:R:K102	1.44	No	No	0	6	7
261	R:R:E272	R:R:S270	1.44	No	No	0	3	2
262	R:R:I244	R:R:L248	1.43	No	No	0	4	3
263	R:R:I258	R:R:L285	1.43	No	No	0	5	5
264	R:R:I280	R:R:L261	1.43	No	Yes	2	8	8
265	R:R:I280	R:R:L267	1.43	No	Yes	2	8	1
266	R:R:I188	R:R:N185	1.42	No	Yes	0	3	4
267	R:R:Q316	R:R:T313	1.42	No	No	0	3	3
268	R:R:E231	R:R:T227	1.41	No	No	0	4	3
269	R:R:E343	R:R:K346	1.35	No	No	0	5	8
270	R:R:F315	R:R:T313	1.3	No	No	0	2	3
271	R:R:T99	R:R:Y98	1.25	No	No	0	6	4
272	R:R:F86	R:R:L90	1.22	No	No	0	5	6
273	R:R:R279	R:R:R282	1.07	No	No	0	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:C81	3.77	4	5	6
2	R:R:V91	3.345	4	0	9
3	R:R:Y108	6.49	5	0	7
4	R:R:F110	5.34	4	0	6
5	R:R:D116	8.12	4	0	9
6	R:R:T122	3.435	4	0	6
7	R:R:L123	3.9875	4	0	7
8	R:R:W135	12.344	5	6	8
9	R:R:F137	8.862	5	0	6
10	R:R:D149	7.9075	4	1	5
11	R:R:Y151	6.205	4	3	5
12	R:R:F154	4.535	4	0	6
13	R:R:T155	7.95	4	3	7
14	R:R:Y168	6.5425	4	0	8
15	R:R:F180	6.7825	4	7	3
16	R:R:R181	7.1725	4	0	7
17	R:R:N185	3.6975	4	7	4
18	R:R:F223	5.168	5	0	6
19	R:R:K235	3.6525	4	0	4
20	R:R:F243	8.0675	4	0	8
21	R:R:Y254	5.77667	6	1	9
22	R:R:L261	3.5725	4	2	8
23	R:R:L267	4.1775	4	2	1
24	R:R:F291	5.406	5	1	9
25	R:R:W295	6.70833	6	1	8
26	R:R:T296	4.34	4	0	5
27	R:R:W320	7.1425	4	0	4
28	R:R:H321	9.5725	4	4	4
29	R:R:Y328	8.0975	4	1	7
30	R:R:N330	7.195	4	1	9
31	R:R:L337	4.2325	4	1	8
32	R:R:Y338	6.49	5	1	9
33	R:R:F345	6.13	4	0	8
34	L:L:?1	6.927	10	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L123	R:R:Y77	13.1835	3.52	Yes	No	0	7	7
2	R:R:C81	R:R:L123	27.9463	4.76	Yes	Yes	0	6	7
3	R:R:C81	R:R:L85	18.1882	3.17	Yes	No	5	6	6
4	R:R:F89	R:R:L85	17.489	3.65	No	No	0	4	6
5	R:R:D116	R:R:N334	48.2244	8.08	Yes	No	0	9	9
6	R:R:N330	R:R:N334	84.5145	8.17	Yes	No	0	9	9
7	R:R:N330	R:R:W295	70.4745	7.91	Yes	Yes	1	9	8
8	L:L:?1	R:R:W295	100	5.16	Yes	Yes	1	0	8
9	L:L:?1	R:R:I324	25.5264	5.54	Yes	No	0	0	5
10	R:R:I324	R:R:W320	23.9158	7.05	No	Yes	0	5	4
11	R:R:H321	R:R:W320	14.5506	5.29	Yes	Yes	0	4	4
12	R:R:D116	R:R:N88	42.1433	6.73	Yes	No	0	9	9
13	R:R:N88	R:R:P335	38.1835	4.89	No	No	0	9	9
14	R:R:F89	R:R:M92	16.3969	3.73	No	No	0	4	7
15	R:R:F110	R:R:I95	17.6069	7.54	Yes	No	0	6	7
16	R:R:F110	R:R:M92	15.8391	6.22	Yes	No	0	6	7
17	R:R:I95	R:R:V91	30.8689	3.07	No	Yes	0	7	9
18	R:R:T99	R:R:Y98	13.27	1.25	No	No	0	6	4
19	R:R:N106	R:R:T99	15.8784	5.85	No	No	0	8	6
20	R:R:F345	R:R:N106	26.1392	7.25	Yes	No	0	8	8
21	R:R:F345	R:R:I95	33.3831	5.02	Yes	No	0	8	7
22	R:R:F340	R:R:V336	13.1442	5.24	No	No	0	6	6
23	R:R:L333	R:R:V336	15.2813	2.98	No	No	0	6	6
24	R:R:L333	R:R:V290	17.4026	4.47	No	No	0	6	7
25	R:R:L337	R:R:V290	19.5082	4.47	Yes	No	0	8	7
26	R:R:L337	R:R:Y338	18.5732	3.52	Yes	Yes	1	8	9
27	R:R:N334	R:R:Y338	83.4381	6.98	No	Yes	0	9	9
28	R:R:D166	R:R:Y108	32.2753	5.75	No	Yes	0	8	7
29	R:R:M163	R:R:Y108	68.4239	5.99	No	Yes	0	9	7
30	R:R:L112	R:R:M163	70.1681	2.83	No	No	0	9	9
31	R:R:L112	R:R:L160	73.6094	5.54	No	No	0	9	8
32	R:R:L160	R:R:Y338	75.3064	8.21	No	Yes	0	8	9
33	R:R:N190	R:R:Y108	32.5189	10.47	No	Yes	0	7	7
34	R:R:N111	R:R:N190	26.2964	6.81	No	No	0	9	7
35	R:R:N111	R:R:W194	24.1908	4.52	No	No	0	9	9
36	R:R:I148	R:R:T122	13.6314	3.04	No	Yes	0	5	6
37	R:R:D149	R:R:T122	61.1015	4.34	Yes	Yes	0	5	6
38	R:R:D149	R:R:Y328	11.8165	8.05	Yes	Yes	1	5	7
39	R:R:L123	R:R:Y328	34.7109	4.69	Yes	Yes	0	7	7
40	L:L:?1	R:R:D149	50.44	11.41	Yes	Yes	1	0	5
41	R:R:T122	R:R:V145	47.5016	4.76	Yes	No	0	6	5
42	R:R:F125	R:R:V145	12.4607	6.55	No	No	0	6	5
43	R:R:F125	R:R:F137	10.7087	4.29	No	Yes	0	6	6
44	R:R:F137	R:R:W135	11.2665	23.05	Yes	Yes	0	6	8
45	R:R:V145	R:R:W135	33.8231	6.13	No	Yes	0	5	8
46	R:R:F137	R:R:V128	10.9522	6.55	Yes	No	0	6	3
47	R:R:C142	R:R:T210	11.4943	3.38	No	No	0	9	4
48	R:R:C142	R:R:W135	13.1364	5.22	No	Yes	6	9	8
49	R:R:G201	R:R:Y151	11.1879	2.9	No	Yes	0	6	5
50	R:R:W194	R:R:Y151	15.4463	10.61	No	Yes	3	9	5
51	L:L:?1	R:R:Y150	43.6361	6.07	Yes	No	0	0	4
52	R:R:L221	R:R:Y150	40.3991	3.52	No	No	0	4	4
53	R:R:I157	R:R:P246	10.803	3.39	No	No	0	7	8
54	R:R:F291	R:R:W295	31.6703	7.02	Yes	Yes	1	9	8
55	R:R:F291	R:R:I250	39.7392	5.02	Yes	No	1	9	8
56	R:R:I250	R:R:S164	29.5255	4.64	No	No	1	8	9
57	R:R:C253	R:R:S164	55.759	5.16	No	No	0	8	9
58	R:R:D166	R:R:F180	21.818	5.97	No	Yes	0	8	3
59	R:R:R167	R:R:Y254	17.2533	8.23	No	Yes	0	9	9
60	R:R:R167	R:R:Y338	17.4576	6.17	No	Yes	0	9	9
61	R:R:C172	R:R:Y168	41.8526	8.06	No	Yes	0	7	8
62	R:R:C253	R:R:Y168	53.4805	6.72	No	Yes	0	8	8
63	R:R:R260	R:R:V171	34.868	2.62	No	No	0	5	8
64	R:R:C172	R:R:R260	39.472	4.18	No	No	0	7	5
65	R:R:L261	R:R:V171	29.9183	4.47	Yes	No	2	8	8
66	R:R:F180	R:R:N185	10.9522	4.83	Yes	Yes	7	3	4
67	R:R:F223	R:R:L221	38.8749	3.65	Yes	No	0	6	4
68	R:R:E231	R:R:F223	11.675	9.33	No	Yes	0	4	6
69	R:R:F223	R:R:W230	21.4016	3.01	Yes	No	0	6	1
70	R:R:W230	R:R:Y229	17.8111	12.54	No	No	0	1	1
71	R:R:L233	R:R:Y229	10.0487	5.86	No	No	0	3	1
72	R:R:F239	R:R:H299	10.6458	3.39	No	No	0	6	7
73	R:R:H299	R:R:W295	25.8799	8.46	No	Yes	0	7	8
74	R:R:F243	R:R:H299	14.1892	18.1	Yes	No	0	8	7
75	R:R:F243	R:R:T296	16.8212	7.78	Yes	Yes	0	8	5
76	R:R:V287	R:R:Y254	22.4466	3.79	No	Yes	1	8	9
77	R:R:V287	R:R:Y338	17.5833	7.57	No	Yes	1	8	9
78	R:R:F291	R:R:V247	13.0107	2.62	Yes	No	0	9	6
79	R:R:L261	R:R:L267	12.72	4.15	Yes	Yes	2	8	1
80	R:R:I280	R:R:N276	12.7357	2.83	No	No	0	8	5
81	R:R:I280	R:R:L261	14.8334	1.43	No	Yes	2	8	8
82	R:R:N276	R:R:R279	10.1744	12.05	No	No	0	5	7
83	R:R:W320	R:R:Y301	10.9365	5.79	Yes	No	0	4	5
84	L:L:?1	R:R:Y328	23.7979	12.89	Yes	Yes	1	0	7
85	R:R:P335	R:R:V91	36.2429	3.53	No	Yes	0	9	9
86	R:R:F291	R:R:N330	16.3184	4.83	Yes	Yes	1	9	9
87	R:R:S164	R:R:Y254	28.4884	10.17	No	Yes	1	9	9
88	R:R:F243	R:R:V247	10.8108	2.62	Yes	No	0	8	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D149	R:R:T122	4.34	1	Yes	Yes	5	6	1	2
R:R:L123	R:R:Y328	4.69	0	Yes	Yes	7	7	2	1
R:R:D149	R:R:Q126	7.83	1	Yes	No	5	6	1	1
R:R:Q126	R:R:Y328	6.76	1	No	Yes	6	7	1	1
L:L:?1	R:R:Q126	11.19	1	Yes	No	0	6	0	1
R:R:D149	R:R:Y328	8.05	1	Yes	Yes	5	7	1	1
L:L:?1	R:R:D149	11.41	1	Yes	Yes	0	5	0	1
R:R:V204	R:R:Y150	3.79	0	No	No	5	4	2	1
R:R:L221	R:R:Y150	3.52	0	No	No	4	4	2	1
L:L:?1	R:R:Y150	6.07	1	Yes	No	0	4	0	1
R:R:F154	R:R:M153	3.73	0	Yes	No	6	7	2	1
R:R:M153	R:R:W295	4.65	1	No	Yes	7	8	1	1
L:L:?1	R:R:M153	9.14	1	Yes	No	0	7	0	1
R:R:F291	R:R:I157	7.54	1	Yes	No	9	7	2	2
R:R:I157	R:R:W295	7.05	1	No	Yes	7	8	2	1
R:R:F291	R:R:W295	7.02	1	Yes	Yes	9	8	2	1
R:R:F291	R:R:N330	4.83	1	Yes	Yes	9	9	2	2
R:R:H299	R:R:W295	8.46	0	No	Yes	7	8	2	1
R:R:N330	R:R:W295	7.91	1	Yes	Yes	9	8	2	1
L:L:?1	R:R:W295	5.16	1	Yes	Yes	0	8	0	1
R:R:C323	R:R:I298	3.27	0	No	No	6	6	2	1
R:R:I324	R:R:W320	7.05	0	No	Yes	5	4	1	2
L:L:?1	R:R:I324	5.54	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y328	12.89	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:V238	2.89	1	Yes	No	0	5	0	1
L:L:?1	R:R:I298	2.77	1	Yes	No	0	6	0	1
L:L:?1	R:R:G327	2.21	1	Yes	No	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8EF5_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.04
Number of Linked Nodes	258
Number of Links	273
Number of Hubs	34
Number of Links mediated by Hubs	135
Number of Communities	8
Number of Nodes involved in Communities	39
Number of Links involved in Communities	48

Path Summary
Number Of Nodes in MetaPath	89
Number Of Links MetaPath	88
Number of Shortest Paths	34235
Length Of Smallest Path	3
Average Path Length	12.7166
Length of Longest Path	28
Minimum Path Strength	1.36
Average Path Strength	5.84362
Maximum Path Strength	20.665
Minimum Path Correlation	0.7
Average Path Correlation	0.923376
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	51.7914
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.0203
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	7V7
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	7V7
Name	Fentanyl
Synonyms	N-(1-phenethyl-4-piperidinyl)-N-phenylpropionamide
Identifier
Formula	C22 H28 N2 O
Molecular Weight	336.471
SMILES
PubChem	3345
Formal Charge	0
Total Atoms	53
Total Chiral Atoms	0
Total Bonds	55
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35372
Sequence	>8EF5_nogp_Chain_R S M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T K M K T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G T W P F G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H P V K A L D F R T P R N A K I I N V C N W I L S S A I G L P V M F M A T T K Y R Q G S I D C T L T F S H P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V R M L S G S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T I P E T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F K R C F R E F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4DKL	A	Peptide	Opioid	μ	Mus musculus	β-Funaltrexamine	-	-	2.8	2012-03-21	doi.org/10.1038/nature10954
	5C1M	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.07	2015-08-05	doi.org/10.1038/nature14886
	6DDE	A	Peptide	Opioid	μ	Mus musculus	DAMGO	-	Gi1/β1/γ2	3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDE (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	DAMGO	-		3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDF	A	Peptide	Opioid	μ	Mus musculus	DAMGO	-	Gi1/β1/γ2	3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	DAMGO	-		3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	7SBF	A	Peptide	Opioid	μ	Mus musculus	PZM21	-	Gi1/β1/γ2	2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SBF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	PZM21	-		2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG	A	Peptide	Opioid	μ	Mus musculus	FH210	-	Gi1/β1/γ2	3	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	FH210	-		3	2022-04-20	doi.org/10.1002/anie.202200269
	7U2L	A	Peptide	Opioid	μ	Mus musculus	C5-guano	-	Gi1/β1/γ2	3.2	2022-05-04	doi.org/10.1038/s41586-022-05588-y
	7U2L (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	C5-guano	-		3.2	2022-05-04	doi.org/10.1038/s41586-022-05588-y
	7UL4	A	Peptide	Opioid	μ	Mus musculus	Alvimopan	-	-	2.8	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	8EF5	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-	Gi1/β1/γ2	3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF5 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-		3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF6	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF6 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFB	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFB (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFL	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFL (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-	Gi1/β1/γ2	2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-		2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFQ	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-	Gi1/β1/γ2	3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFQ (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-		3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	7T2G	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-	Gi1/β1/γ2	2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2G (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-		2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2H	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-	Gi1/β1/γ2	2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2H (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-		2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7U2K	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-	Gi1/β1/γ2	3.3	2022-12-07	doi.org/10.1038/s41586-022-05588-y
	7U2K (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-		3.3	2022-12-07	doi.org/10.1038/s41586-022-05588-y
	8F7Q	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-	Gi1/β1/γ2	3.22	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7Q (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-		3.22	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7R	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	Gi1/β1/γ2	3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7R (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8K9K	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-	Gi3/β1/γ1	2.98	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9K (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-		2.98	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9L	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	BMS-986122	Gi3/β1/γ1	3.05	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9L (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	BMS-986122		3.05	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	9BJK	A	Peptide	Opioid	μ	Mus musculus	Naloxone	PubChem 171642066	-	3.26	2024-07-17	doi.org/10.1038/s41586-024-07587-7
	9BQJ	A	Peptide	Opioid	μ	Mus musculus	RO76	-	Gi1/β1/γ2	3.3	2024-09-11	doi.org/10.1021/acscentsci.4c00525
	9BQJ (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	RO76	-		3.3	2024-09-11	doi.org/10.1021/acscentsci.4c00525
	9MQH	A	Peptide	Opioid	μ	Homo sapiens	-	-	-	3.9	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQI	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.3	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQJ	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.23	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9WST	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-	chim(NtGi1-Gz)/β1/γ2	2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WST (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-		2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSV	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-	Arrestin2	2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSV (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-		2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSW	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	chim(NtGi1-Gz)/β1/γ2	2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSW (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSX	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	Arrestin2	2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSX (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		2.8	2025-11-26	10.1038/s41422-025-01191-8
	8E0G	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.1	2023-10-18	doi.org/10.1186/s12915-023-01689-w
	8QOT	A	Peptide	Opioid	μ	Mus musculus	Nanobody-E	-	-	3.2	2023-12-27	doi.org/10.1101/2023.12.06.570395
	8Y72	A	Peptide	Opioid	μ	Homo sapiens	Peptide	BMS-986122	Gi1/β1/γ2	2.65	2025-08-06	To be published
	8Y72 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Peptide	BMS-986122		2.65	2025-08-06	To be published
	8Y73	A	Peptide	Opioid	μ	Homo sapiens	Peptide	MPAM-15	Gi1/β1/γ2	2.84	2025-08-06	To be published
	8Y73 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Peptide	MPAM-15		2.84	2025-08-06	To be published
	9PXU	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	Na	-	3.4	2025-11-12	10.1038/s41586-025-09677-6
	9PXV	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	-	Gi1/β1/γ2	3.02	2025-11-12	10.1038/s41586-025-09677-6
	9PXV (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	-		3.02	2025-11-12	10.1038/s41586-025-09677-6
	9PXW	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS	Gi1/β1/γ2	3.8	2025-11-12	10.1038/s41586-025-09677-6
	9PXW (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS		3.8	2025-11-12	10.1038/s41586-025-09677-6
	9PXX	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS	Gi1/β1/γ2	3.1	2025-11-12	10.1038/s41586-025-09677-6
	9PXX (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS		3.1	2025-11-12	10.1038/s41586-025-09677-6
	9PXY	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS	Gi1/β1/γ2	3	2025-11-12	10.1038/s41586-025-09677-6
	9PXY (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS		3	2025-11-12	10.1038/s41586-025-09677-6
	9PY2	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS	Gi1/β1/γ2	3.16	2025-11-12	10.1038/s41586-025-09677-6
	9PY2 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS		3.16	2025-11-12	10.1038/s41586-025-09677-6
	9PY3	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS	Gi1/β1/γ2	3.2	2025-11-12	To be published
	9PY3 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS		3.2	2025-11-12	To be published
	9PY4	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS	Gi1/β1/γ2	2.78	2025-11-12	10.1038/s41586-025-09677-6
	9PY4 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS		2.78	2025-11-12	10.1038/s41586-025-09677-6
	9ODJ	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	GTP; Mg	Gi1/β1/γ2	3	2026-01-07	10.1038/s41586-025-10056-4
	9ODJ (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	GTP; Mg		3	2026-01-07	10.1038/s41586-025-10056-4
	9ODK	A	Peptide	Opioid	μ	Mus musculus	-	GTP; Mg	Gi1/β1/γ2	3.9	2026-01-07	10.1038/s41586-025-10056-4
	9ODK (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	-	GTP; Mg		3.9	2026-01-07	10.1038/s41586-025-10056-4
	9ODL	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	GTP; Mg	Gi1/β1/γ2	3.6	2026-01-07	10.1038/s41586-025-10056-4
	9ODL (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	GTP; Mg		3.6	2026-01-07	10.1038/s41586-025-10056-4

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8EF5_nogp.zip

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