Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:Y1 6.634500
2W:W:?1 10.6562820
3L:L:?2 8.768510
4L:L:?4 9.47714710
5R:R:I73 7.625446
6R:R:Y77 6.278507
7R:R:I95 5.04407
8R:R:Y108 4.92407
9R:R:W135 7.454518
10R:R:N152 6.7625408
11R:R:F154 6.73406
12R:R:T155 5.5407
13R:R:I157 4.4527
14R:R:W158 9.996505
15R:R:Y168 6.422508
16R:R:W194 9.785409
17R:R:F223 4.476506
18R:R:W230 5.415401
19R:R:F243 7.265408
20R:R:P246 4.5975428
21R:R:W295 6.508528
22R:R:Y301 6.03615
23R:R:Q316 5.97403
24R:R:W320 8.3675414
25R:R:N334 7.2475439
26R:R:Y338 6.975439
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?2 L:L:Y1 65.818514.31YesYes000
2L:L:Y1 R:R:Y150 24.49263.97YesNo004
3L:L:Y1 R:R:M153 98.84694.79YesNo007
4L:L:Y1 R:R:V302 13.0593.79YesNo005
5R:R:F154 R:R:M153 99.05547.46YesNo067
6R:R:F154 R:R:W158 1009.02YesYes065
7R:R:W158 W:W:?1 69.439626.1YesYes050
8R:R:T162 W:W:?1 21.645910.81NoYes070
9R:R:V165 W:W:?1 52.823317.75NoYes060
10R:R:I157 R:R:W158 29.16473.52YesYes075
11L:L:?2 L:L:?4 38.16864.87YesYes100
12L:L:?4 R:R:C219 26.75214.12YesNo109
13L:L:?4 R:R:Q126 19.160914.97YesNo006
14R:R:Q126 R:R:Y77 18.36527.89NoYes067
15R:R:H321 R:R:Y77 25.31386.53NoYes047
16R:R:H321 R:R:I73 19.569415.91NoYes446
17L:L:?2 R:R:W320 25.909513.9YesYes104
18R:R:I324 R:R:W320 14.55264.7NoYes054
19R:R:I324 R:R:Y77 13.81228.46NoYes057
20R:R:C219 R:R:W135 12.30596.53NoYes198
21R:R:C81 R:R:L123 14.75269.52NoNo067
22R:R:C81 R:R:L85 12.37823.17NoNo066
23R:R:N193 R:R:W158 73.98416.78NoYes075
24R:R:N193 R:R:T159 39.58134.39NoNo078
25R:R:L112 R:R:T159 26.29255.9NoNo098
26R:R:L112 R:R:N334 12.446313.73NoYes399
27R:R:N111 R:R:T159 17.48444.39NoNo098
28R:R:N111 R:R:W194 15.458911.3NoYes099
29R:R:L114 R:R:W194 37.73033.42NoYes079
30R:R:L114 R:R:M92 34.63264.24NoNo077
31R:R:F110 R:R:M92 31.52633.73NoNo067
32R:R:N193 R:R:S197 35.73894.47NoNo078
33R:R:S197 R:R:Y151 15.22063.82NoNo085
34R:R:W194 R:R:Y151 13.348413.5YesNo095
35R:R:S197 R:R:T155 19.6634.8NoYes087
36R:R:T155 R:R:W194 14.046210.92YesYes079
37R:R:I169 R:R:V165 51.76383.07NoNo056
38R:R:I169 R:R:Y168 50.69572.42NoYes058
39R:R:C172 R:R:Y168 42.98129.41NoYes078
40R:R:C172 R:R:R260 41.84082.79NoNo075
41R:R:R260 R:R:V171 39.61962.62NoNo058
42R:R:L261 R:R:V171 37.2754.47NoNo088
43R:R:I280 R:R:L261 24.0164.28NoNo088
44R:R:I280 R:R:R279 22.83735.01NoNo087
45R:R:E343 R:R:R279 13.69313.96NoNo057
46R:R:E343 R:R:K346 12.44212.15NoNo058
47R:R:F345 R:R:K346 11.09311.24NoNo088
48R:R:F110 R:R:I95 28.41163.77NoYes067
49R:R:I95 R:R:T99 19.01627.6YesNo076
50R:R:N106 R:R:T99 15.867416.08NoNo086
51R:R:N106 R:R:T103 12.710110.24NoNo087
52R:R:T162 R:R:Y108 20.35666.24NoYes077
53R:R:A186 R:R:Y108 12.4424NoYes077
54R:R:L112 R:R:L160 12.8255.54NoNo398
55R:R:D149 R:R:Y150 15.42915.75NoNo054
56R:R:D149 R:R:Y328 12.59525.75NoNo057
57R:R:C142 R:R:C219 13.4257.28NoNo199
58R:R:C142 R:R:T210 12.86753.38NoNo094
59R:R:V204 R:R:Y150 10.45915.05NoNo054
60R:R:I157 R:R:W295 29.90518.22YesYes278
61R:R:L160 R:R:Y338 12.50164.69NoYes389
62R:R:H299 R:R:W295 25.83293.17NoYes078
63R:R:F243 R:R:H299 21.560813.58YesNo087
64R:R:F223 R:R:L221 12.75694.87YesNo064
65R:R:F223 R:R:W230 12.12294.01YesYes061
66R:R:K235 R:R:V302 12.00374.55NoNo045
67R:R:F243 R:R:T296 12.38677.78YesNo085
68R:R:L261 R:R:L277 13.59942.77NoNo086
69R:R:W320 R:R:Y301 12.6086.75YesYes145
70R:R:L123 R:R:Y328 12.016515.24NoNo077
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:Y1 R:R:Y150 3.97 0 Yes No 0 4 0 1
L:L:Y1 R:R:M153 4.79 0 Yes No 0 7 0 1
L:L:Y1 R:R:V238 6.31 0 Yes No 0 5 0 1
L:L:Y1 R:R:V302 3.79 0 Yes No 0 5 0 1
L:L:?2 R:R:W320 13.9 1 Yes Yes 0 4 0 1
L:L:?4 R:R:Q126 14.97 1 Yes No 0 6 0 1
L:L:?4 R:R:V145 3.87 1 Yes No 0 5 0 1
L:L:?4 R:R:I146 8.64 1 Yes No 0 4 0 1
L:L:?4 R:R:C219 4.12 1 Yes No 0 9 0 1
L:L:?5 R:R:T220 3.97 1 No No 0 4 0 1
R:R:Q126 R:R:Y77 7.89 0 No Yes 6 7 1 2
R:R:I324 R:R:Y77 8.46 0 No Yes 5 7 2 2
R:R:F125 R:R:V145 3.93 0 No No 6 5 2 1
R:R:C142 R:R:W135 5.22 1 No Yes 9 8 2 2
R:R:C219 R:R:W135 6.53 1 No Yes 9 8 1 2
R:R:C142 R:R:C219 7.28 1 No No 9 9 2 1
R:R:I146 R:R:L221 4.28 0 No No 4 4 1 2
R:R:D149 R:R:Y150 5.75 0 No No 5 4 2 1
R:R:V204 R:R:Y150 5.05 0 No No 5 4 2 1
R:R:F154 R:R:M153 7.46 0 Yes No 6 7 2 1
R:R:L221 R:R:V204 4.47 0 No No 4 5 2 2
R:R:D218 R:R:T220 5.78 0 No No 4 4 2 1
R:R:K235 R:R:V302 4.55 0 No No 4 5 2 1
R:R:K305 R:R:Y301 4.78 1 No Yes 3 5 2 2
R:R:W320 R:R:Y301 6.75 1 Yes Yes 4 5 1 2
R:R:K305 R:R:W320 8.12 1 No Yes 3 4 2 1
R:R:I324 R:R:W320 4.7 0 No Yes 5 4 2 1
R:R:A208 R:R:I146 3.25 0 No No 5 4 2 1
R:R:K211 R:R:T220 3 0 No No 1 4 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:W158 W:W:?1 26.1 0 Yes Yes 5 0 1 0
R:R:C161 W:W:?1 4.36 2 No Yes 7 0 1 0
R:R:T162 W:W:?1 10.81 0 No Yes 7 0 1 0
R:R:V165 W:W:?1 17.75 0 No Yes 6 0 1 0
R:R:F180 W:W:?1 3.35 0 No Yes 3 0 1 0
R:R:F241 W:W:?1 6.7 0 No Yes 4 0 1 0
R:R:M245 W:W:?1 11.66 2 No Yes 5 0 1 0
R:R:P246 W:W:?1 4.52 2 Yes Yes 8 0 1 0
R:R:T162 R:R:Y108 6.24 0 No Yes 7 7 1 2
R:R:F154 R:R:W158 9.02 0 Yes Yes 6 5 2 1
R:R:I157 R:R:W158 3.52 2 Yes Yes 7 5 2 1
R:R:I157 R:R:P246 3.39 2 Yes Yes 7 8 2 1
R:R:N193 R:R:W158 6.78 0 No Yes 7 5 2 1
R:R:L196 R:R:W158 4.56 0 No Yes 4 5 2 1
R:R:C161 R:R:P246 3.77 2 No Yes 7 8 1 1
R:R:M245 R:R:P246 6.71 2 No Yes 5 8 1 1
R:R:I169 R:R:V165 3.07 0 No No 5 6 2 1
R:R:F241 R:R:I240 2.51 0 No No 4 5 1 2
R:R:C161 R:R:I249 1.64 2 No No 7 6 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8K9L_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.35
Number of Linked Nodes 269
Number of Links 284
Number of Hubs 26
Number of Links mediated by Hubs 108
Number of Communities 5
Number of Nodes involved in Communities 30
Number of Links involved in Communities 37
Path Summary
Number Of Nodes in MetaPath 71
Number Of Links MetaPath 70
Number of Shortest Paths 44892
Length Of Smallest Path 3
Average Path Length 14.3612
Length of Longest Path 32
Minimum Path Strength 1.405
Average Path Strength 7.0655
Maximum Path Strength 21.925
Minimum Path Correlation 0.7
Average Path Correlation 0.931398
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.16667
Average % Of Corr. Nodes 52.6191
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 36.7445
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeVV9
PDB ResiduesW:W:?1
Environment DetailsOpen EMBL-EBI Page
CodeVV9
Name(2~{S})-2-(3-bromanyl-4-methoxy-phenyl)-3-(4-chlorophenyl)sulfonyl-1,3-thiazolidine
SynonymsBMS-986122
Identifier
FormulaC16 H15 Br Cl N O3 S2
Molecular Weight448.782
SMILES
PubChem1271268
Formal Charge0
Total Atoms39
Total Chiral Atoms1
Total Bonds41
Total Aromatic Bonds12

CodeDAL
PDB ResiduesL:L:?2
Environment DetailsOpen EMBL-EBI Page
CodeDAL
NameD-Alanine
Synonyms(R)-alanine
Identifier
FormulaC3 H7 N O2
Molecular Weight89.093
SMILES
PubChem71080
Formal Charge0
Total Atoms13
Total Chiral Atoms1
Total Bonds12
Total Aromatic Bonds0

CodeMEA
PDB ResiduesL:L:?4
Environment DetailsOpen EMBL-EBI Page
CodeMEA
NameN-METHYLPHENYLALANINE
Synonyms
Identifier
FormulaC10 H13 N O2
Molecular Weight179.216
SMILES
PubChem6951134
Formal Charge0
Total Atoms26
Total Chiral Atoms1
Total Bonds26
Total Aromatic Bonds6

CodeETA
PDB ResiduesL:L:?5
Environment DetailsOpen EMBL-EBI Page
CodeETA
NameEthanolamine
Synonyms
  • Ethanolamine hydrochloride
  • Ethanolamine acetate
  • Ethanolamine
Identifier
FormulaC2 H7 N O
Molecular Weight61.083
SMILES
PubChem700
Formal Charge0
Total Atoms11
Total Chiral Atoms0
Total Bonds10
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP35372
Sequence
>8K9L_nogp_Chain_R
SMITAITIM ALYSIVCVV GLFGNFLVM YVIVRYTKM KTATNIYIF 
NLALADALA TSTLPFQSV NYLMGTWPF GTILCKIVI SIDYYNMFT 
SIWTLCTMS VDRYIAVCH PVKALDFRT PRNAKIINV CNWILSSAI 
GLPVMFMAT TKYRQGSID CTLTFSHPT WYWENLLKI CVFIFAFIM 
PVLIITVCY GLMILRLKS VRMLSGSKE KDRNLRRIT RMVLVVVAV 
FIVCWTPIH IYVIIKALV TIPETTFQT VSWHFCIAL GYTNSCLNP 
VLYAFLDEN FKR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9BJKAPeptideOpioidμMus musculusNaloxoneNAM-3.262024-07-17doi.org/10.1038/s41586-024-07587-7
8K9LAPeptideOpioidμHomo sapiensDamgoBMS-986122Gi3/β1/γ13.052024-05-29doi.org/10.1038/s41467-024-47792-6
8K9L (No Gprot) APeptideOpioidμHomo sapiensDamgoBMS-9861223.052024-05-29doi.org/10.1038/s41467-024-47792-6
7SBFAPeptideOpioidμMus musculusPZM21-Gi1/β1/γ22.92022-04-20doi.org/10.1002/anie.202200269
7SBF (No Gprot) APeptideOpioidμMus musculusPZM21-2.92022-04-20doi.org/10.1002/anie.202200269
7SCGAPeptideOpioidμMus musculusFH210-Gi1/β1/γ232022-04-20doi.org/10.1002/anie.202200269
7SCG (No Gprot) APeptideOpioidμMus musculusFH210-32022-04-20doi.org/10.1002/anie.202200269
8EF5APeptideOpioidμHomo sapiensFentanyl-Gi1/β1/γ23.32022-11-09doi.org/10.1016/j.cell.2022.09.041
8EF5 (No Gprot) APeptideOpioidμHomo sapiensFentanyl-3.32022-11-09doi.org/10.1016/j.cell.2022.09.041
8EF6APeptideOpioidμHomo sapiensMorphine-Gi1/β1/γ23.22022-11-09doi.org/10.1016/j.cell.2022.09.041
8EF6 (No Gprot) APeptideOpioidμHomo sapiensMorphine-3.22022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFBAPeptideOpioidμHomo sapiensOliceridine-Gi1/β1/γ23.22022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFB (No Gprot) APeptideOpioidμHomo sapiensOliceridine-3.22022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFLAPeptideOpioidμHomo sapiensSR17018-Gi1/β1/γ23.22022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFL (No Gprot) APeptideOpioidμHomo sapiensSR17018-3.22022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFOAPeptideOpioidμHomo sapiensPZM21-Gi1/β1/γ22.82022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFO (No Gprot) APeptideOpioidμHomo sapiensPZM21-2.82022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFQAPeptideOpioidμHomo sapiensDamgo-Gi1/β1/γ23.32022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFQ (No Gprot) APeptideOpioidμHomo sapiensDamgo-3.32022-11-09doi.org/10.1016/j.cell.2022.09.041
8F7QAPeptideOpioidμHomo sapiensβ-Endorphin-Gi1/β1/γ23.222022-12-14doi.org/10.1016/j.cell.2022.12.026
8F7Q (No Gprot) APeptideOpioidμHomo sapiensβ-Endorphin-3.222022-12-14doi.org/10.1016/j.cell.2022.12.026
8F7RAPeptideOpioidμHomo sapiensEndomorphin-Gi1/β1/γ23.282022-12-14doi.org/10.1016/j.cell.2022.12.026
8F7R (No Gprot) APeptideOpioidμHomo sapiensEndomorphin-3.282022-12-14doi.org/10.1016/j.cell.2022.12.026
9BQJAPeptideOpioidμMus musculusRO76-Gi1/β1/γ23.32024-09-11doi.org/10.1021/acscentsci.4c00525
9BQJ (No Gprot) APeptideOpioidμMus musculusRO76-3.32024-09-11doi.org/10.1021/acscentsci.4c00525
4DKLAPeptideOpioidμMus musculusβ-Funaltrexamine--2.82012-03-21doi.org/10.1038/nature10954
5C1MAPeptideOpioidμMus musculusBU72--2.072015-08-05doi.org/10.1038/nature14886
8K9KAPeptideOpioidμHomo sapiensDamgo-Gi3/β1/γ12.982024-05-29doi.org/10.1038/s41467-024-47792-6
8K9K (No Gprot) APeptideOpioidμHomo sapiensDamgo-2.982024-05-29doi.org/10.1038/s41467-024-47792-6
6DDEAPeptideOpioidμMus musculusDamgo-Gi1/β1/γ23.52018-06-13doi.org/10.1038/s41586-018-0219-7
6DDE (No Gprot) APeptideOpioidμMus musculusDamgo-3.52018-06-13doi.org/10.1038/s41586-018-0219-7
6DDFAPeptideOpioidμMus musculusDamgo-Gi1/β1/γ23.52018-06-13doi.org/10.1038/s41586-018-0219-7
6DDF (No Gprot) APeptideOpioidμMus musculusDamgo-3.52018-06-13doi.org/10.1038/s41586-018-0219-7
7U2LAPeptideOpioidμMus musculusPubChem 163201242-Gi1/β1/γ23.22022-05-04doi.org/10.1038/s41586-022-05588-y
7U2L (No Gprot) APeptideOpioidμMus musculusPubChem 163201242-3.22022-05-04doi.org/10.1038/s41586-022-05588-y
7U2KAPeptideOpioidμMus musculusC6-guano-Gi1/β1/γ23.32022-12-07doi.org/10.1038/s41586-022-05588-y
7U2K (No Gprot) APeptideOpioidμMus musculusC6-guano-3.32022-12-07doi.org/10.1038/s41586-022-05588-y
7T2GAPeptideOpioidμMus musculusMitragynine Pseudoindoxyl-Gi1/β1/γ22.52022-12-07doi.org/10.1038/s41589-022-01208-y
7T2G (No Gprot) APeptideOpioidμMus musculusMitragynine Pseudoindoxyl-2.52022-12-07doi.org/10.1038/s41589-022-01208-y
7T2HAPeptideOpioidμMus musculusLofentanil-Gi1/β1/γ22.52022-12-07doi.org/10.1038/s41589-022-01208-y
7T2H (No Gprot) APeptideOpioidμMus musculusLofentanil-2.52022-12-07doi.org/10.1038/s41589-022-01208-y
7UL4APeptideOpioidμMus musculusAlvimopan--2.82022-06-29doi.org/10.1038/s41594-022-00859-8
8QOTAPeptideOpioidμMus musculusNanobody-E--3.22023-12-27doi.org/10.1101/2023.12.06.570395
9MQHAPeptideOpioidμHomo sapiens---3.92025-02-12doi.org/10.1101/2025.01.09.632033
9MQIAPeptideOpioidμHomo sapiensIsoquinuclidine--3.32025-02-12doi.org/10.1101/2025.01.09.632033
9MQJAPeptideOpioidμHomo sapiensIsoquinuclidine--3.232025-02-12doi.org/10.1101/2025.01.09.632033
8E0GAPeptideOpioidμMus musculusBU72--2.12023-10-18doi.org/10.1186/s12915-023-01689-w
8Y73APeptideOpioidμHomo sapiensPeptideMPAM-15Gi1/β1/γ22.842025-08-06To be published
8Y73 (No Gprot) APeptideOpioidμHomo sapiensPeptideMPAM-152.842025-08-06To be published
8Y72APeptideOpioidμHomo sapiensPeptideBMS-986122Gi1/β1/γ22.652025-08-06To be published
8Y72 (No Gprot) APeptideOpioidμHomo sapiensPeptideBMS-9861222.652025-08-06To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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